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Improving standardized in vitro digestion protocols for phytosterols (PSs) is critical for understanding their bioaccessibility (BA) in food products and supplements. In this study, in vitro BA of phytosterol esters (PSEs) and free cholesterol (Ch) was compared under modified digestion conditions. The addition of Ch esterase (CE) to the INFOGEST model containing bovine bile resulted in a 70% increase in PS BA and an 18.5% reduction in Ch micellarization. Relative to the standardized INFOGEST model, substitution of pure bile salts (PBSs) did not significantly change PS BA or Ch micellarization. In the presence of CE, the substitution resulted in a 49.9% reduction in PS BA and a 13% increase in Ch micellarization. The differing results may be due to inhibitory effects of PBSs on the activity of intestinal enzymes, including CE. These results suggest that the INFOGEST model should include Ch esterase and the continued use of bile extract to evaluate PS BA.

Cultural geography has a long tradition of embracing video as both an observational method and a form of public engagement with research findings. In this article, we describe the making of Posthuman Landscapes, a silent film composed of moving panoramic images depicting the landscapes of three regional Australian towns (Griffith, Port Hedland, and Port Lincoln), along with creative writing that responded to the material qualities of those places in the form of ‘tweets’. Created as part of Boyd’s 3-year project called ‘Engaging Youth in Regional Australia’, the film formed part of a touring exhibition designed to disseminate research findings to communities within these towns. As artist-geographers, we approached the making of the video from a posthuman perspective in which the human and non-human are entangled. Our conceptual guide for working creatively with the landscapes was the posthuman concept of enchantment, which considers how the extraordinary can appear within the everyday to shake and disrupt ordinary affects. The concept of enchantment inspired us to juxtapose the inevitable familiarity and unfamiliarity that the audiences in these three towns would encounter through the film as it traveled from place to place. Here, we discuss how this juxtaposition of the familiar and unfamiliar was layered through both our film-making and writing practices, how this juxtaposition attempted to promote a posthuman orientation to landscape, and how such creative engagements contribute to knowledge translation in cultural geographical research.

After considering the nature and role of creative co-production in research contexts, Boyd describes the processes involved in producing artworks for the ‘Finding Home’ exhibition based on research findings from the Engaging Youth in Regional Australia (EYRA) Study. Commencing with work produced by some of the study’s participants, Boyd moves on to discuss the commissioning of a set of textile works and a contemporary Aboriginal artwork for the exhibition. The chapter is interwoven with a description of Boyd’s own artworks as an artist-geographer, produced in response but also in sympathy with the rest of the exhibition as it emerged. The chapter concludes with some first-hand reflections on curating a research exhibition.

In this final chapter, Boyd considers the strengths and limitations of the methods used to evaluate the ‘Finding Home’ exhibition, including what can or can’t be measured about the visitor experience. This is further elaborated by pointing out that part of what visitors experience in response to an art exhibition is ineffable, and in making this point, Boyd returns to the concept of affective knowledge translation introduced in Chap. 1. Boyd goes on to emphasise the importance of establishing rapport in working with multiple actors during the production of an art exhibition, as well as raising some caveats about research exhibitions as a ‘technique’ of knowledge translation. Boyd suggests how universities can better support art-based knowledge translation efforts and concludes with some thoughts about transdisciplinarity.

In this chapter, Boyd summarises the Engaging Youth in Regional Australia (EYRA) Study whose findings formed the basis of the touring art exhibition called ‘Finding Home’. Rooted in placed-based understandings of youth belonging and well-being, the study sought to challenge some of the long-standing assumptions about young people’s internal migration decisions in regional Australia. Specifically, the study’s findings support an enhanced understanding of regional youth engagement that takes into account the affective and material dimensions of young people’s relationships with regional places.

Beginning with the discipline of geography and its intersections with the humanities, Boyd explores how art has made its way across the academy to the social sciences and health and into science itself. Maintaining a focus on how art has become a vehicle for knowledge translation and exchange, the chapter builds a case for art as geography, especially in the realm of affective knowledge translation.

Background Transthyretin amyloidosis, also called ATTR amyloidosis, is a life-threatening disease characterized by progressive accumulation of misfolded transthyretin (TTR) protein in tiss...

PURPOSE: The objective of this work was to evaluate phantom dosimetry of a novel kilovoltage (kV) x-ray source, which employs a stationary tungsten anode and a linearly swept scanning electron-beam. The source utilizes converging x-ray collimation along with orthogonal mechanical rotation to distribute surface flux over large area. In this study, this was investigated as a potential solution to fast-falloff limitations expected with kV radiotherapy. This was done with the aim of future clinical development of a lower-cost radiotherapy alternative to megavoltage (MV) linac systems. METHODS: Radiochromic film was employed for dosimetry on the kV x-ray source of the Linear-Converging Radiotherapy System (LCRS). The source utilizes charge particle optics to magnetically deflect and focus an electron beam along a stationary, reflection tungsten target in an ultra-high-vacuum stainless-steel chamber. Resulting x-rays were collimated into converging beamlets that span a large planar angle and converge at the system isocenter. In this study, radiochromic film dosimetry was done at 140 and 145 kVp for a designated planning treatment volume (PTV) of 4-cm diameter. An acrylic phantom was employed for dose distribution measurements of stationary and rotational delivery. Film dosimetry was evaluated in planes parallel to the source x-ray window at various depths, as well as in the plane of gantry rotation. RESULTS: At 140 and 145 kVp and using a collimated 4-cm square field at depth, lesion-to-skin dose ratio was shown to improve with additional beams from different relative source positions, where the different beams are focused at the same isocenter and do not overlap at the phantom surface. It was only possible to achieve a 1:1 D(max)-to-surface ratio with four delivery beams, but the ratio improved to 4:1 with 12 beams, focused at the same isocenter depth of 7.8 cm in an acrylic phantom. For the tests conducted, the following D(max)-to-surface ratios were obtained: 0.4:1 lesion-to-skin ratio for stationary delivery from one entry beam, 0.71:1 lesion-to-skin ratio was obtained for two beams, 1.07:1 ratio for four beams, and 4:1 for 12 beams. Dose-depth profiles were evaluated for stationary and rotational dosimetry. Additionally, rotational dosimetry was measured for a case more analogous to a clinical scenario, where the isocenter was located at an off-center simulated lesion. CONCLUSIONS: The results demonstrate potential dose-depth improvements with kV arc therapy by distributing the surface flux with a wide converging beam along with perpendicular mechanical source rotation of the LCRS. The system delivered tolerable dose to a large surface area when a threshold of multiple, separated beams was reached. The radiochromic film data supports the feasibility of the construct of the LCRS kV radiotherapy system design.

The ability of computed tomography (CT) to distinguish between benign congenital lung malformations and malignant cystic pleuropulmonary blastomas (PPBs) is unclear.To assess whether chest CT can detect malignant tumors among postnatally detected lung lesions in children.This retrospective multicenter case-control study used a consortium database of 521 pathologically confirmed primary lung lesions from January 1, 2009, through December 31, 2015, to assess diagnostic accuracy. Preoperative CT scans of children with cystic PPB (cases) were selected and age-matched with CT scans from patients with postnatally detected congenital lung malformations (controls). Statistical analysis was performed from January 18 to September 6, 2020. Preoperative CT scans were interpreted independently by 9 experienced pediatric radiologists in a blinded fashion and analyzed from January 24, 2019, to September 6, 2020.Accuracy, sensitivity, and specificity of CT in correctly identifying children with malignant tumors.Among 477 CT scans identified (282 boys [59%]; median age at CT, 3.6 months [IQR, 1.2-7.2 months]; median age at resection, 6.9 months [IQR, 4.2-12.8 months]), 40 cases were extensively reviewed; 9 cases (23%) had pathologically confirmed cystic PPB. The median age at CT was 7.3 months (IQR, 2.9-22.4 months), and median age at resection was 8.7 months (IQR, 5.0-24.4 months). The sensitivity of CT for detecting PPB was 58%, and the specificity was 83%. High suspicion for malignancy correlated with PPB pathology (odds ratio, 13.5; 95% CI, 2.7-67.3; P = .002). There was poor interrater reliability (κ = 0.36 [range, 0.06-0.64]; P .001) and no significant difference in specific imaging characteristics between PPB and benign cystic lesions. The overall accuracy rate for distinguishing benign vs malignant lesions was 81%.This study suggests that chest CT, the current criterion standard imaging modality to assess the lung parenchyma, may not accurately and reliably distinguish PPB from benign congenital lung malformations in children. In any cystic lung lesion without a prenatal diagnosis, operative management to confirm pathologic diagnosis is warranted.

Goosegrass control options in bermudagrass are limited. Topramezone is one option that offers excellent control of mature goosegrass, but application to bermudagrass results in unacceptable symptoms of bleaching and necrosis typical of hydroxyphenylpyruvate dioxygenase inhibitors. Previous research has shown that adding chelated iron reduced the phytotoxicity of topramezone without reducing the efficacy of the herbicide, resulting in safening when applied to bermudagrass. Our objective was to examine additional iron sources to determine whether similar safening effects occur with other sources. Field trials were conducted in the summers of 2016 to 2018 (Auburn University). Mixtures of topramezone and methylated seed oil were combined with six different commercial iron sources, including sodium ferric ethylenediamine di-o-hydroxyphenyl-acetate (FeEDDHA), ferrous diethylenetriamine pentaacetic acid (FeDTPA), iron citrate, FeSO4, and a combination of iron oxide/sucrate/sulfate, some of which contained nitrogen. Bermudagrass necrosis and bleaching symptoms were visually rated on a 0% to 100% scale. Reflectance (normalized difference vegetation index) and clipping yield measurements were also collected. Application of FeDTPA and FeSO4 reduced symptoms of bleaching and necrosis when applied with topramezone. Other treatments that contained nitrogen did not reduce injury but did reduce bermudagrass recovery time following the appearance of necrosis. Inclusion of small amounts of nitrogen often negated the safening effects of FeSO4. The iron oxide/sucrate/sulfate product had no effect on bleaching or necrosis. Data suggest that the iron source had a differential effect on bleaching and necrosis reduction when applied in combination with topramezone to bermudagrass. Overall, FeSO4 and FeDTPA safened topramezone the most on bermudagrass.

POST goosegrass and other grassy weed control in bermudagrass is problematic. Fewer herbicides that can control goosegrass are available due to regulatory pressure and herbicide resistance. Alternative herbicide options that offer effective control are needed. Previous research demonstrates that topramezone controls goosegrass, crabgrass, and other weed species; however, injury to bermudagrass may be unacceptable. The objective of this research was to evaluate the safening potential of topramezone combinations with different additives on bermudagrass. Field trials were conducted at Auburn University during summer and fall from 2015 to 2018 and 2017 to 2018, respectively. Treatments included topramezone mixtures and methylated seed oil applied in combination with five different additives: triclopyr, green turf pigment, green turf paint, ammonium sulfate, and chelated iron. Bermudagrass bleaching and necrosis symptoms were visually rated. Normalized-difference vegetative index measurements and clipping yield data were also collected. Topramezone plus chelated iron, as well as topramezone plus triclopyr, reduced bleaching potential the best; however, the combination of topramezone plus triclopyr resulted in necrosis that outweighed reductions in bleaching. Masking agents such as green turf paint and green turf pigment were ineffective in reducing injury when applied with topramezone. The combination of topramezone plus ammonium sulfate should be avoided because of the high level of necrosis. Topramezone-associated bleaching symptoms were transient and lasted 7 to 14 d on average. Findings from this research suggest that chelated iron added to topramezone and methylated seed oil mixtures acted as a safener on bermudagrass.

In classrooms, the act of saying hello - the ritual of shaking hands or hugging, and taking the time to exchange information – can enact relational values of “We”-ness, of belonging. In this paper we highlight how one second grade teacher’s personalized and consistent use of greetings, and apprenticeship of students into how to greet and be greeted, functions to build community and involvement. Data are part of a two-year case study of a second-grade classroom in a diverse urban US context. This study examines approximately 16 weeks of classroom greeting data collected from Morning Meetings (10 hours, 39 minutes) and then homes in on 5 minutes across one day for a close look at the apprenticeship into, and roles of, being a greeter. Analysis explicates how greetings are used in different ways across time and how they work together to build classroom community togetherness. We argue that classroom greetings are a partial marker of dialogic pedagogy.

Desmoplastic small round cell tumor is a rare sarcoma with 5-year overall survival of 15%. An 8-year-old female presented with diffuse abdominal/pelvic desmoplastic small round cell tumor including numerous liver metastasis. She underwent neoadjuvant chemotherapy followed by cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Residual disease was found shortly after CRS/HIPEC which was resected, followed by whole abdomen/pelvic radiation and autologous hematopoietic cell transplant. Previous papers have reported dismal survival in patients with liver metastasis and residual disease arguing against CRS/HIPEC. Our patient remains disease-free over 6 years after completing therapy indicating long-term survival is achievable with aggressive multimodal therapy.

We study the rotations of a heavy string (helicoseir) about a vertical axis with one free endpoint and with arbitrary density, under the action of the gravitational force. We show that the problem can be transformed into a nonlinear eigenvalue equation, as in the uniform case. The eigenmodes of this equation represent equilibrium configurations of the rotating string in which the shape of the string doesn't change with time. As previously proved by Kolodner for the homogenous case, the occurrence of new modes of the nonlinear equation is tied to the spectrum of the corresponding linear equation. We have been able to generalize this result to a class of densities $\rho(s) = \gamma (1-s)^{\gamma-1}$, which includes the homogenous string as a special case ($\gamma=1$). We also show that the solutions to the nonlinear eigenvalue equation (NLE) for an arbitrary density are orthogonal and that a solution of this equation with a given number of nodes contains solutions of a different helicoseir, with a smaller number of nodes. Both properties hold also for the homogeneous case and had not been established before., Comment: 13 pages, 3 figures

We consider the well-studied problem of decomposing a vector time series signal into components with different characteristics, such as smooth, periodic, nonnegative, or sparse. We describe a simple and general framework in which the components are defined by loss functions (which include constraints), and the signal decomposition is carried out by minimizing the sum of losses of the components (subject to the constraints). When each loss function is the negative log-likelihood of a density for the signal component, this framework coincides with maximum a posteriori probability (MAP) estimation; but it also includes many other interesting cases. Summarizing and clarifying prior results, we give two distributed optimization methods for computing the decomposition, which find the optimal decomposition when the component class loss functions are convex, and are good heuristics when they are not. Both methods require only the masked proximal operator of each of the component loss functions, a generalization of the well-known proximal operator that handles missing entries in its argument. Both methods are distributed, i.e., handle each component separately. We derive tractable methods for evaluating the masked proximal operators of some loss functions that, to our knowledge, have not appeared in the literature., The manuscript has 61 pages, 22 figures and 2 tables. Also hosted at https://web.stanford.edu/~boyd/papers/sig_decomp_mprox.html. For code, see https://github.com/cvxgrp/signal-decomposition

Decision making algorithms are used in a multitude of different applications. Conventional approaches for designing decision algorithms employ principled and simplified modelling, based on which one can determine decisions via tractable optimization. More recently, deep learning approaches that use highly parametric architectures tuned from data without relying on mathematical models, are becoming increasingly popular. Model-based optimization and data-centric deep learning are often considered to be distinct disciplines. Here, we characterize them as edges of a continuous spectrum varying in specificity and parameterization, and provide a tutorial-style presentation to the methodologies lying in the middle ground of this spectrum, referred to as model-based deep learning. We accompany our presentation with running examples in super-resolution and stochastic control, and show how they are expressed using the provided characterization and specialized in each of the detailed methodologies. The gains of combining model-based optimization and deep learning are demonstrated using experimental results in various applications, ranging from biomedical imaging to digital communications.

We report the detection and characterization of the transiting sub-Neptune TOI-1759 b, using photometric time-series from TESS and near infrared spectropolarimetric data from SPIRou on the CFHT. TOI-1759 b orbits a moderately active M0V star with an orbital period of $18.849975\pm0.000006$ d, and we measure a planetary radius and mass of $3.06\pm0.22$ R$_\oplus$ and $6.8\pm2.0$ M$_\oplus$. Radial velocities were extracted from the SPIRou spectra using both the CCF and the LBL methods, optimizing the velocity measurements in the near infrared domain. We analyzed the broadband SED of the star and the high-resolution SPIRou spectra to constrain the stellar parameters and thus improve the accuracy of the derived planet parameters. A LSD analysis of the SPIRou Stokes $V$ polarized spectra detects Zeeman signatures in TOI-1759. We model the rotational modulation of the magnetic stellar activity using a GP regression with a quasi-periodic covariance function, and find a rotation period of $35.65^{+0.17}_{-0.15}$ d. We reconstruct the large-scale surface magnetic field of the star using ZDI, which gives a predominantly poloidal field with a mean strength of $18\pm4$ G. Finally, we perform a joint Bayesian MCMC analysis of the TESS photometry and SPIRou RVs to optimally constrain the system parameters. At $0.1176\pm0.0013$ au from the star, the planet receives $6.4$ times the bolometric flux incident on Earth, and its equilibrium temperature is estimated at $433\pm14$ K. TOI-1759 b is a likely gas-dominated sub-Neptune with an expected high rate of photoevaporation. Therefore, it is an interesting target to search for neutral hydrogen escape, which may provide important constraints on the planetary formation mechanisms responsible for the observed sub-Neptune radius desert., Accepted for publication in the 10. Planets and planetary systems section of Astronomy & Astrophysics

Clinical genetic testing enables the detection of specific gene mutations and variants that predispose individuals and their family members to disease. In recent years, tremendous strides have been made in the variety of clinically useful tests. Targeted testing for specific mutations that cause well-known syndromes enables the efficient diagnosis of genetic diseases with cutaneous manifestations. Testing for specific genes, however, may not always reveal a diagnosis. Expanded options are available. This review outlines the major types of available technology with a focus on those tests most useful for pediatric dermatologists.

Little is known about health professions students’ awareness and attitudes regarding public health in the United States. Therefore, the purpose of this study was to assess medical and pharmacy students’ knowledge and interest in the Healthy People initiative as well as perceptions of public health content in their curricula. An electronic survey was distributed in March 2021 in seven schools across Ohio, participation was incentivized through a USD 5 donation to the Ohio Association of Foodbanks to aid in COVID-19 relief efforts (maximum USD 1000) for each completed survey. A total of 182 medical students and 233 pharmacy students participated (12% response rate). Less than one-third of respondents reported familiarity with Healthy People and correctly identified the latest edition. However, nearly all respondents agreed public health initiatives are valuable to the American healthcare system. Almost all students expressed a desire to practice interprofessionally to attain public health goals. Both medical and pharmacy students recognized core public health topics in their curricula, and nearly 90% wanted more information. These findings indicate that the majority of medical and pharmacy students in Ohio believe public health initiatives to be important, yet knowledge gaps exist regarding Healthy People. This information can guide curricular efforts and inform future studies of health professions students.

Cosmic microwave background (CMB) measurements are fundamentally limited by photon statistics. Therefore, ground-based CMB observatories have been increasing the number of detectors that are simultaneously observing the sky. Thanks to the advent of monolithically fabricated transition edge sensor (TES) arrays, the number of on-sky detectors has been increasing exponentially for over a decade. The next-generation experiment CMB-S4 will increase this detector count by more than an order of magnitude from the current state-of-the-art to ~500,000. The readout of such a huge number of exquisitely precise sub-Kelvin sensors is feasible using an existing technology: frequency-domain multiplexing (fMux). To further optimize this system and reduce complexity and cost, we have recently made significant advances including the elimination of 4 K electronics, a massive decrease of parasitic in-series impedances, and a significant increase in multiplexing factor., Comment: 7 pages, 6 figures, Submitted to the JLTP for LTD-18

We report a new measurement of the 60 keV transition from 241Am. It uses a metallic magnetic calorimeter gamma-ray detector calibrated in the region around 60 keV by four accurately known X-rays and gamma rays from the decay of 169Yb. We determine an energy of 59,539.3 ± 0.3 (stat) ± 0.3 (syst) eV, which is 1.6 ± 0.4 eV lower than the current literature value of 59,540.9 ± 0.1 eV. We discuss the sources of this uncertainty and approaches to address them.

Metallic magnetic calorimeters (MMCs) combine the excellent energy resolution of cryogenic gamma ray detectors with a very small nonlinearity and a reproducible response, owing to their magnetization-based sensor and their metallic heat flow path. These attributes make MMCs well suited for photon and particle spectroscopy applications requiring the highest accuracy. We are developing high-resolution MMC gamma ray detectors with the goal of improving the quality of key nuclear decay data for nuclear safeguards and fundamental science. Our exploratory “integrated” (SQUIDs and sensors on the same chip) 14-pixel MMC designs recently demonstrated energy resolution of 37.5 eV at 60 keV. Here, we describe the design and optimization for a new generation of MMC detectors using both “integrated” and “split” designs (SQUIDs and sensors on separate chips). The new designs are expected to have an energy resolution

With ever-increasing laser power, the requirements for ultraviolet (UV) coatings increase continuously. The fundamental challenge for UV laser-resistant mirror coatings is to simultaneously exhibit a high reflectivity with a large bandwidth and high laser resistance. These characteristics are traditionally achieved by the deposition of laser-resistant layers on highly reflective layers. We propose a “reflectivity and laser resistance in one” design by using tunable nanolaminate layers that serve as an effective layer with a high refractive index and a large optical bandgap. An Al2O3–HfO2 nanolaminate-based mirror coating for UV laser applications is experimentally demonstrated using e-beam deposition. The bandwidth, over which the reflectance is >99.5%, is more than twice that of a traditional mirror with a comparable overall thickness. The laser-induced damage threshold is increased by a factor of ~1.3 for 7.6 ns pulses at a wavelength of 355 nm. This tunable, nanolaminate-based new design strategy paves the way toward a new generation of UV coatings for high-power laser applications.

This paper defines the notion of dialogic local space and highlights its importance to teaching and learning. A dialogic local space values multiple local realities as it invites us to listen to, t...

There is a long history of collaboration between artists and geographers, with creative forms of research and dissemination of findings taking shape as artworks. In addition, there has been significant push from academia for researchers to maximise their research in ways that cater to, and engage with, broader public audiences. Art and creative practices tap into this through formats such as exhibitions, performances and participatory workshops which draw upon arts-based research methodologies with which geographers are becoming increasingly engaged. However, with this enthusiasm to adopt art practices for research dissemination purposes, tensions can arise in determining the levels of collaboration and authorship between artists and geographers, especially when the artist is employed as a research assistant on the project. In this ‘In Practice’ article, we explore the tensions and challenges that creative collaborations produce with respect to copyright and authorship, specialist skills and the delicate balance of doing creative research as part of a research team. We argue that geographers and artists need to address these issues from the outset and revisit them throughout the research process, and we offer some suggestions for how art–geography research collaborations might best be negotiated.

In an age of billion dollar particle accelerators and Mars rovers, it is surprising that solitary waves were first discovered by a man on horseback with no tools but his own eyes. A century and a h...

Chebyshev polynomial spectral methods are very accurate, but are plagued by the cost and ill-conditioning of dense discretization matrices. Modified schemes, collectively known as “integration sparsification”, have mollified these problems by discretizing the highest derivative as a diagonal matrix. Here, we examine five case studies where the highest derivative diagonalization fails. Nevertheless, we show that Galerkin discretizations do yield banded matrices that retain most of the advantages of “integration sparsification”. Symbolic computer algebra greatly extends the reach of spectral methods. When spectral methods are implemented using exact rational arithmetic, as is possible for small truncation N in Maple, Mathematica and their ilk, roundoff error is irrelevant, and sparsification failure is not worrisome. When the discretization contains a parameter L , symbolic algebra spectral methods return, as answer to an eigenproblem, not discrete numbers but rather a plane algebraic curve defined as the zero set of a bivariate polynomial P ( λ , L ) ; the optimal approximations to the eigenvalues λ j are in the middle of the straight portions of the zero contours of P ( λ ; L ) where the isolines are parallel to the L axis.

This study of whole class minilesson talk adds to the literature on how teacher talk shapes student involvement with learning. Minilesson talk is commonly associated with monologic, authoritative t...

When members of a classroom community routinely listen to one another and build on one another's ideas, not only do students learn and improve their cognitive and communication skills, but teacher and students develop a disposition to listen, think and talk together. However, such dialogic, classroom talk is rare. In this study we show how a teacher's epistemological commitment (that student ideas matter) combined with oracy practices (safe space for student talk; student ideas drive classroom talk; support multiple perspectives) realized through speculation and reasoning (S&R) words foster dialogic talk. We examined S&R words (think, would, might/maybe, if, so, but, how, why) in 1299 turns of talk in two lessons in one classroom of six 4–5th grade English Language Learners. Statistical discourse analysis showed that S&R words occurred more often during what we refer to as connect episodes (students made personal connections to the content), not after particular types of turns. Close discourse analysis showed how S&R word use cultivated a language of possibility and how management of classroom discourse modality promoted dialogic talk.

Objective To assess the nocioceptive input of habitual nocturnal jaw clenching that acts as a contributing factor in migraine pathogenesis. Background Habitual nocturnal jaw clenching has been implicated as a trigger, particularly in those whose headaches are present upon waking or shortly thereafter. Nocturnal EMG studies of patients diagnosed with migraine show nearly twice the temporalis clenching EMG levels and double the bite force as matched asymptomatic controls, leading to the speculation that parafunctional clenching activity may have some role in headache pathogenesis. The NTI (Nociceptive Trigeminal Inhibition) oral device is a dental splint designed to reduce nocturnal jaw clenching intensity and is FDA approved for the prevention of medically diagnosed migraine pain based on open label studies. There are no prior placebo-controlled trials to assess the migraine prevention efficacy of the NTI splint. This is the first placebo-controlled cross-over study to assess the efficacy of the NTI splint in patients with Chronic Migraine. Method A placebo controlled, single-blinded cross-over study was done with IRB oversight assessing the efficacy of the NTI splint compared to placebo using the change in the HIT-6 score as the outcome measure. Results 68% of refractory chronic migraine sufferers using the NTI as measured by sequential HIT 6 scores had at least a one-category improvement (severe to substantial, or substantial to some, or some to none) compared to 12% when using a placebo device. 36% of subjects using the NTI device reported a two-category improvement in their HIT-6 score, compared to 0% when using placebo. Conclusion The improvement in HIT-6 scores produced by the NTI device, suggests that patients with Chronic Migraine may have intense nocturnal jaw clenching as a contributing factor to their headache related disability. An NTI device is one method of assessing whether jaw-clenching is a contributing factor to ongoing migraine. Trial registration Current Controlled Trials NCT04871581. 04/05/2021. Retrospectively registered.

BACKGROUND: Pediatric lung lesions are a group of mostly benign pulmonary anomalies with a broad spectrum of clinical disease and histopathology. Our objective was to evaluate the characteristics of children undergoing resection of a primary lung lesion and to identify preoperative risk factors for malignancy. METHODS: A retrospective cohort study was conducted by using an operative database of 521 primary lung lesions managed at 11 children’s hospitals in the United States. Multivariable logistic regression was used to examine the relationship between preoperative characteristics and risk of malignancy, including pleuropulmonary blastoma (PPB). RESULTS: None of the 344 prenatally diagnosed lesions had malignant pathology (P < .0001). Among 177 children without a history of prenatal detection, 15 (8.7%) were classified as having a malignant tumor (type 1 PPB, n = 11; other PPB, n = 3; adenocarcinoma, n = 1) at a median age of 20.7 months (interquartile range, 7.9–58.1). Malignancy was associated with the DICER1 mutation in 8 (57%) PPB cases. No malignant lesion had a systemic feeding vessel (P = .0427). The sensitivity of preoperative chest computed tomography (CT) for detecting malignant pathology was 33.3% (95% confidence interval [CI]: 15.2–58.3). Multivariable logistic regression revealed that increased suspicion of malignancy by CT and bilateral disease were significant predictors of malignant pathology (odds ratios of 42.15 [95% CI, 7.43–340.3; P < .0001] and 42.03 [95% CI, 3.51–995.6; P = .0041], respectively). CONCLUSIONS: In pediatric lung masses initially diagnosed after birth, the risk of PPB approached 10%. These results strongly caution against routine nonoperative management in this patient population. DICER1 testing may be helpful given the poor sensitivity of CT for identifying malignant pathology.

People with brain cancer and their support persons (SPs) are critical sources of information on the components of care that contribute to psychosocial outcomes.To determine the proportion of studies that examined (1) at least one of 14 nominated components of psychosocial cancer care and (2) more than one component of care.Medline, The Cochrane Library, PsycINFO and Embase were electronically searched for publications from January 1999 to December 2019. Publications that met the inclusion criteria were coded according to the number and type of psychosocial care components assessed from 14 listed components, and whether patient and/or SPs' views about care were elicited.Of the 113 included publications, 61 publications included patient-reported data only (54%), 27 included both patient and SP-reported data (24%) and 25 included SP-reported data only (22%). Most assessed a single component of care (77% of patient-reported and 71% of SP-reported). No publications assessed all 14 components. The "Psychosocial" component was the most frequently assessed component of care for patient-reported (n = 80/88, 91%) and SP-reported publications (n = 46/52, 88%).Publications reporting on psychosocial care in brain cancer present a relatively narrow view of patient and support person experiences. The inclusion of both patient and support person perspectives and the assessment of multiple components of care are required in future research to optimize psychosocial outcomes in brain cancer.

The Deep Underground Neutrino Experiment (DUNE) will be a powerful tool for a variety of physics topics. The high-intensity proton beams provide a large neutrino flux, sampled by a near detector system consisting of a combination of capable precision detectors, and by the massive far detector system located deep underground. This configuration sets up DUNE as a machine for discovery, as it enables opportunities not only to perform precision neutrino measurements that may uncover deviations from the present three-flavor mixing paradigm, but also to discover new particles and unveil new interactions and symmetries beyond those predicted in the Standard Model (SM). Of the many potential beyond the Standard Model (BSM) topics DUNE will probe, this paper presents a selection of studies quantifying DUNE's sensitivities to sterile neutrino mixing, heavy neutral leptons, non-standard interactions, CPT symmetry violation, Lorentz invariance violation, neutrino trident production, dark matter from both beam induced and cosmogenic sources, baryon number violation, and other new physics topics that complement those at high-energy colliders and significantly extend the present reach.

The deep underground neutrino experiment (DUNE), a 40-kton underground liquid argon time projection chamber experiment, will be sensitive to the electron-neutrino flavor component of the burst of neutrinos expected from the next Galactic core-collapse supernova. Such an observation will bring unique insight into the astrophysics of core collapse as well as into the properties of neutrinos. The general capabilities of DUNE for neutrino detection in the relevant few- to few-tens-of-MeV neutrino energy range will be described. As an example, DUNE’s ability to constrain the νe spectral parameters of the neutrino burst will be considered. © 2021, The Author(s).

Childhood obesity is a serious health problem in the United States that affects millions of children and adolescents. Obese children are more prone to chronic illnesses, and these risks persist into adulthood. The Richard B. Russell National School Lunch Act (42 U.S.C. 1751 et seq.) sought to promote better nutrition among children, especially those who may otherwise not have access to healthy meals, by providing lunches that meet defined nutritional standards. Despite this effort, obesity rates continue to rise and there is little evidence favoring the effectiveness of the National School Lunch Act in reducing obesity incidence among children. Recently, policymakers proposed expanding nutrition education efforts to the classroom to address the current limitations of the National School Lunch Act (i.e., H.R.5892 and S.3293). However, education efforts alone are insufficient to foster long-lasting healthy eating patterns among children. Therefore, we propose that Congress amend the National School Lunch Act to include three evidence-based approaches: a 50-hour education program (H.R.5892), equitable partnerships between schools, local businesses and nonprofit organizations (S.3293), and a community engagement program designed to impact dietary behavior beyond the classroom.