1. Synthesis and structure of organoplatinum(II) complexes containing aryl olefins and 8-hydroxyquinolines
- Author
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Nguyen Thi Ngoc Vinh, Luu Thi Tuyen, Tran Thi Da, Luc Van Meervelt, and Le Thi Hong Hai
- Subjects
8-hydroxyquinolines ,EUGENOL ,organoplatinum ,010402 general chemistry ,010403 inorganic & nuclear chemistry ,01 natural sciences ,Medicinal chemistry ,chemistry.chemical_compound ,Materials Chemistry ,Chemistry, Inorganic & Nuclear ,CYTOTOXICITY ,Physical and Theoretical Chemistry ,Organoplatinum ,Science & Technology ,Aryl ,SAFROLE ,0104 chemical sciences ,Chemistry ,PLATINUM(II) COMPLEXES ,Safrole ,chemistry ,SPECTRAL CHARACTERIZATION ,PALLADIUM(II) ,Physical Sciences ,Platinum(II) complex ,Hydroxyquinolines - Abstract
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. Twelve new organoplatinum(II) complexes: [PtCl(Saf)(2-Me-8-OquiN)] (1), [PtCl(Saf)(5,7-Cl 2 -8-OquiN)] (2), [PtCl(Saf)(5,7-Cl 2 -2-Me-8-OquiN)] (3), [PtCl(Meteug)(5,7-Cl 2 -8-OquiN)] (4), [PtCl(Meteug)(5,7-Cl 2 -2-Me-8-OquiN)] (5), [Pt(Saf-1H)(2-Me-8-OquiN)] (6), [Pt(Saf-1H)(5,7-Cl 2 -8-OquiN)] (7), [Pt(Saf-1H)(5,7-Cl 2 -2-Me-8-OquiN)] (8), [Pt(Eteug-1H)(2-Me-8-OquiN)] (9), [Pt(Eteug-1H)(2-OHC-8-OquiN)] (10), [Pt(Eteug-1H)(5,7-Cl 2 -8-OquiN)] (11) and [Pt(Eteug-1H)(5,7-Cl 2 -2-Me-8-OquiN)] (12) (Saf: Safrole, Meteug: Methyl eugenoxyacetate, Saf-1H: Deprotonated safrole, Eteug-1H: Deprotonated ethyl eugenoxyacetate, OquiN: substituted quinolin-8-olate) were synthesized. These complexes were characterized by elemental analyses, IR, 1 H NMR, for several also by NOESY, MS spectra and 9 by single-crystal X-ray diffraction. It is shown that in 1-5 the Pt(II) ion is surrounded by a Cl ion and the ethylenic double bond of the aryl olefin, and by N and O atoms of the 8-OquiN, its donor N is in trans-position in comparison with the ethylenic double bond. In 6-12 the Pt(II) ion is surrounded by an aromatic C atom and the ethylenic C = C double bond of the aryl olefin, and by N and O atoms of the 8-OquiN resulting in a slightly distorted square-planar coordination environment; the donor N is in cis-position in comparison with the ethylenic double bond. Complexes 2, 4 and 7 exhibit high activities on human cancer cells KB, Hep-G2, Lu and MCF-7 with most IC 50 values lower than those of cisplatin. ispartof: JOURNAL OF COORDINATION CHEMISTRY vol:72 issue:10 pages:1637-1651 status: published
- Published
- 2019