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1. Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis

Author

Jesson, Julie, Crichton, Siobhan, Quartagno, Matteo, Yotebieng, Marcel, Abrams, Elaine J., Chokephaibulkit, Kulkanya, Le Coeur, Sophie, Aké-Assi, Marie-Hélène, Patel, Kunjal, Pinto, Jorge, Paul, Mary, Vreeman, Rachel, Davies, Mary-Ann, Ben-Farhat, Jihane, Van Dyke, Russell, Judd, Ali, Mofenson, Lynne, Vicari, Marissa, Seage, George, Bekker, Linda-Gail, Essajee, Shaffiq, Gibb, Diana, Penazzato, Martina, Collins, Intira Jeannie, Wools-Kaloustian, Kara, Slogrove, Amy, Powis, Kate, Williams, Paige, Matshaba, Mogomotsi, Thahane, Lineo, Nyasulu, Phoebe, Lukhele, Bhekumusa, Mwita, Lumumba, Kekitiinwa-Rukyalekere, Adeodata, Wanless, Sebastian, Goetghebuer, Tessa, Thorne, Claire, Warszawski, Josiane, Galli, Luisa, van Rossum, Annemarie M. C., Giaquinto, Carlo, Marczynska, Magdalena, Marques, Laura, Prata, Filipa, Ene, Luminita, Okhonskaya, Lyuba, Navarro, Marisa, Frick, Antoinette, Naver, Lars, Kahlert, Christian, Volokha, Alla, Chappell, Elizabeth, Pape, Jean William, Rouzier, Vanessa, Marcelin, Adias, Succi, Regina, Sohn, Annette H., Kariminia, Azar, Edmonds, Andrew, Lelo, Patricia, Lyamuya, Rita, Ogalo, Edith Apondi, Odhiambo, Francesca Akoth, Haas, Andreas D., Bolton, Carolyn, Muhairwe, Josephine, Tweya, Hannock, Sylla, Mariam, D'Almeida, Marceline, Renner, Lorna, Abzug, Mark J., Oleske, James, Purswani, Murli, Teasdale, Chloe, Nuwagaba-Biribonwoha, Harriet, Goodall, Ruth, Leroy, Valériane, Universitat Autònoma de Barcelona, Institut Català de la Salut, [Jesson J] CERPOP, Inserm, Université Paul Sabatier Toulouse 3, Toulouse, France. [Crichton S, Quartagno M] MRC Clinical Trials Unit, University College London, London, UK. [Yotebieng M] Division of General Internal Medicine, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA. [Abrams EJ] ICAP at Columbia University, Mailman School of Public Health, Columbia University, New York, USA. [Chokephaibulkit K] Siriraj Institute of Clinical Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Salaya, Thailand. [Frick A] Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus, Medical Microbiology & Infectious Diseases, and Pediatrics

Subjects
Adult, Male, Adolescent, virosis::infecciones por virus ARN::infecciones por Retroviridae::infecciones por Lentivirus::infecciones por VIH [ENFERMEDADES], Other subheadings::Other subheadings::/epidemiology [Other subheadings], growth, Perinatally acquired, 610 Medicine & health, adolescent, CD4, cohort studies, HIV, perinatally acquired, CD4 Lymphocyte Count, Child, Child, Preschool, Cohort Studies, Female, Growth Disorders, Humans, Income, HIV Infections, Growth, Adolescents, SDG 3 - Good Health and Well-being, 360 Social problems & social services, Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV Infections [DISEASES], Preschool, Otros calificadores::Otros calificadores::/epidemiología [Otros calificadores], Public Health, Environmental and Occupational Health, Infeccions per VIH - Epidemiologia, Infectious Diseases, Cohort studies
Abstract

HIV; Adolescent; Perinatally acquired VIH; Adolescent; Adquirit perinatalment VIH; Adolescente; Adquirida perinatalmente Introduction Adolescents living with HIV are subject to multiple co-morbidities, including growth retardation and immunodeficiency. We describe growth and CD4 evolution during adolescence using data from the Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) global project. Methods Data were collected between 1994 and 2015 from 11 CIPHER networks worldwide. Adolescents with perinatally acquired HIV infection (APH) who initiated antiretroviral therapy (ART) before age 10 years, with at least one height or CD4 count measurement while aged 10–17 years, were included. Growth was measured using height-for-age Z-scores (HAZ, stunting if 7 years in sub-Saharan African regions. At age 10, stunting ranged from 6% in North America and Europe to 39% in the Asia-Pacific; 19% overall had CD4 counts

Published
2022

2. Outcomes of second-line antiretroviral therapy among children living with HIV: a global cohort analysis

Author

Patel, Kunjal, Smith, Colette, Collins, Intira Jeannie, Goodall, Ruth, Abrams, Elaine J, Sohn, Annette H, Mohamed, Thahira J, Van Dyke, Russell B, Rojo, Pablo, Wools‐kaloustian, Kara, Pinto, Jorge, Edmonds, Andrew, Marete, Irene, Paul, Mary, Nuwaqaba‐biribonwoha, Harriet, Leroy, Valériane, Davies, Mary‐ann, Vreeman, Rachel, Maxwell, Nicky, Timmerman, Venessa, Duff, Charlotte, Mofenson, Lynne, Bekker, Linda‐gail, Vicari, Marissa, Essajee, Shaffiq, Penazzato, Martina, Slogrove, Amy, Williams, Paige, Crichton, Siobhan, Seage, George, Thahane, Lineo, Kazembe, Peter N, Lukhele, Bhekumusa, Mwita, Lumumba, Kekitiinwa‐rukyalekere, Adeodata, Wanless, Sebastian, Matshaba, Mogomotsi S, Goetghebuer, Tessa, Thorne, Claire, Warszawski, Josiane, Galli, Luisa, Geelen, Sybil, Gibb, Diana M, Giaquinto, Carlo, Marczynska, Magdalena, Marques, Laura, Prata, Filipa, Ene, Luminita, Okhonskaia, Liubov, Noguera‐julian, Antoni, Naver, Lars, Rudin, Christoph, Jourdain, Gonzague, Judd, Ali, Volokha, Alla, Rouzier, Vanessa, Succi, Regina, Kariminia, Azar, Yotebieng, Marcel, Lelo, Patricia, Lyamuya, Rita, Oyaro, Patrick, Boulle, Andrew, Malisita, Kennedy, Fatti, Geoffrey, Haas, Andreas D, Desmonde, Sophie, Dicko, Fatoumata, Abzug, Mark J, Purswani, Murli, Van Dyke, Russell, Chadwick, Ellen, Abrams, Elaine, Teasdale, Chloe, and Nuwagaba, Harriet

Subjects
Male, Latin Americans, Infection in children, antiretroviral therapy, children, mortality, outcomes, perinatal HIV, second-line, HIV Infections, Global Health, Cohort Studies, 0302 clinical medicine, Risk of mortality, Medicine, Cumulative incidence, Treatment Failure, 030212 general & internal medicine, 610 Medicine & health, Child, Research Articles, Incidence, Antiretrovirals, Treatment Outcome, Infectious Diseases, Anti-Retroviral Agents, Child, Preschool, Cohort, Female, second‐line, 0305 other medical science, 360 Social problems & social services, Research Article, Cohort study, Context (language use), 03 medical and health sciences, VIH (Virus), Humans, 030505 public health, business.industry, HIV (Viruses), Public Health, Environmental and Occupational Health, Antiretroviral therapy, Antiretroviral agents, CD4 Lymphocyte Count, Regimen, business, Infeccions en els infants, Demography
Abstract

INTRODUCTION Limited data describe outcomes on second-line antiretroviral therapy (ART) among children globally. Our objective was to contribute data on outcomes among children living with HIV after initiation of second-line ART in the context of routine care within a large global cohort collaboration. METHODS Patient-level data from 1993 through 2015 from 11 paediatric HIV cohorts were pooled. Characteristics at switch and through two years of follow-up were summarized for children who switched to second-line ART after starting a standard first-line regimen in North America, Latin America, Europe, Asia, Southern Africa (South Africa & Botswana) and the rest of sub-Saharan Africa (SSA). Cumulative incidences of mortality and loss to follow-up (LTFU) were estimated using a competing risks framework. RESULTS Of the 85,389 children on first-line ART, 3,555 (4%) switched to second-line after a median of 2.8 years on ART (IQR: 1.6, 4.7); 69% were from Southern Africa or SSA and 86% of second-line regimens were protease inhibitor-based. At switch, median age was 8.4 years and 50% had a prior AIDS diagnosis. Median follow-up after switch to second-line ranged from 1.8 years in SSA to 5.3 years in North America. Median CD4 counts at switch to second-line ranged from 235 cells/mm3 in SSA to 828 cells/mm3 in North America. Improvements in CD4 counts were observed over two years of follow-up, particularly in regions with lower CD4 counts at second-line switch. Improvements in weight-for-age z-scores were not observed during follow-up. Cumulative incidence of LTFU at two years was

Published
2020

3. Height and timing of growth spurt during puberty in young people living with vertically acquired HIV in Europe and Thailand

Author

Crichton, Siobhan, Belfrage, Eric, Collins, Intira Jeanne, Doerholt, Katja, Judd, Ali, Le Coeur, Sophie, Spoulou, Vana, Goodall, Ruth, Scherpbier, Henriette, Smit, Colette, Goetghebuer, Tessa, Gibb, Diana M., Noguera, Antoni, Luisa Navarro, Maria, Tomas Ramos, Jose, Galli, Luisa, Giaquinto, Carlo, Thorne, Claire, Santa Ansone, Marczynska, Magdalena, Okhonskaia, Liubov, de Tejada, Begona Martinez, Jourdain, Gonzague, Decker, Luc, Ene, Luminita, Hainaut, Marc, Van der Kelen, Evelyne, Delforge, Marc, de Martino, Maurizio, Tovo, Pier Angelo, Patrizia, Osimani, Larovere, Domenico, Ruggeri, Maurizio, Faldella, Giacomo, Baldi, Francesco, Badolato, Raffaele, Montagnani, Carlotta, Venturini, Elisabetta, Lisi, Catiuscia, Di Biagio, Antonio, Taramasso, Lucia, Giacomet, Vania, Erba, Paola, Esposito, Susanna, Lipreri, Rita, Salvini, Filippo, Tagliabue, Claudia, Cellini, Monica, Bruzzese, Eugenia, Lo Vecchio, Andrea, Rampon, Osvalda, Dona, Daniele, Romano, Amelia, Dodi, Icilio, Maccabruni, Anna, Consolini, Rita, Bernardi, Stefania, Kuekou, Hyppolite Tchidjou, Genovese, Orazio, Olmeo, Paolina, Cristiano, Letizia, Mazza, Antonio, Gabiano, Clara, Garazzino, Silvia, Pellegatta, Antonio, Pajkrt, D., Scherpbier, H. J., Weijsenfeld, A. M., de Boer, C. G., Jurriaans, S., Back, N. K. T., Zaaijer, H. L., Berkhout, B., Cornelissen, M. T. E., Schinkel, C. J., Wolthers, K. C., Fraaij, P. L. A., van Rossum, A. M. C., Vermont, C. L., van der Knaap, L. C., Visser, E. G., Boucher, C. A. B., Koopmans, M. P. G., van Kampen, J. J. A., Pas, S. D., Henriet, S. S., V, van de Flier, M., van Aerde, K., Strik-Albers, R., Rahamat-Langendoen, J., Stelma, F. F., Scholvinck, E. H., de Groot-de Jonge, H., Niesters, H. G. M., van Leer-Buter, C. C., Knoester, M., Bont, L. J., Geelen, S. P. M., Wolfs, T. F. W., Nauta, N., Schuurman, R., Verduyn-Lunel, F., Wensing, A. M. J., Reiss, P., Zaheri, S., Bezemer, D. O., van Sighem, A., I, Smit, C., Wit, F. W. M. N., Hillebregt, M., de Jong, A., Woudstra, T., Bergsma, D., Grivell, S., Meijering, R., Raethke, M., Rutkens, T., de Groot, L., van den Akker, M., Bakker, Y., Bezemer, M., El Berkaoui, A., Geerlinks, J., Koops, J., Kruijne, E., Lodewijk, C., Lucas, E., van der Meer, R., Munjishvili, L., Paling, E., Peeck, B., Ree, C., Regtop, R., Ruijs, Y., van de Sande, L., Schoorl, M., Schnorr, P., Tuijn, E., Veenenberg, L., van der Vliet, S., Wisse, A., Witte, E. C., Tuk, B., Popielska, Jolanta, Pokorska-Spiewak, Maria, Oldakowska, Agnieszka, Zawadka, Konrad, Coupland, Urszula, Doroba, Malgorzata, Voronin, Evgeny, Miloenko, Milana, Labutina, Svetlana, Soler-Palacin, Pere, Antoinette Frick, Maria, Perez-Hoyos, Santiago, Mur, Antonio, Lopez, Nuria, Mendez, Maria, Mayol, Lluis, Vallmanya, Teresa, Calavia, Olga, Garcia, Lourdes, Coll, Maite, Pineda, Valenti, Rius, Neus, Rovira, Nuria, Duenas, Joaquin, Gamell, Anna, Fortuny, Claudia, Noguera-Julian, Antoni, Jose Mellado, Maria, Escosa, Luis, Garcia Hortelano, Milagros, Sainz, Talia, Isabel Gonzalez-Tome, Maria, Rojo, Pablo, Blazquez, Daniel, Prieto, Luis, Guillen, Sara, Saavedra, Jesus, Santos, Mar, Angeles Munoz, Ma, Ruiz, Beatriz, Fernandez Mc Phee, Carolina, Jimenez de Ory, Santiago, Alvarez, Susana, Angel Roa, Miguel, Beceiro, Jose, Martinez, Jorge, Badillo, Katie, Apilanez, Miren, Pocheville, Itziar, Garrote, Elisa, Colino, Elena, Gomez Sirvent, Jorge, Garzon, Monica, Roman, Vicente, Montesdeoca, Abian, Mateo, Mercedes, Jose Munoz, Maria, Angulo, Raquel, Neth, Olaf, Falcon, Lola, Terol, Pedro, Luis Santos, Juan, Moreno, David, Lendinez, Francisco, Grande, Ana, Jose Romero, Francisco, Perez, Carlos, Lillo, Miguel, Losada, Begona, Herranz, Mercedes, Bustillo, Matilde, Guerrero, Carmelo, Collado, Pilar, Antonio Couceiro, Jose, Perez, Amparo, Isabel Piqueras, Ana, Breton, Rafael, Segarra, Inmaculada, Gavilan, Cesar, Jareno, Enrique, Montesinos, Elena, Dapena, Marta, Alvarez, Cristina, Gloria Andres, Ana, Marugan, Victor, Ochoa, Carlos, Alfayate, Santiago, Isabel Menasalvas, Ana, de Miguel, Elisa, Naver, Lars, Soeria-Atmadja, Sandra, Hagas, Vendela, Aebi-Popp, K., Anagnostopoulos, A., Asner, S., Battegay, M., Baumann, M., Bernasconi, E., Boni, J., Braun, D. L., Bucher, H. C., Calmy, A., Cavassini, M., Ciuffi, A., Duppenthaler, A., Dollenmaier, G., Egger, M., Elzi, L., Fehr, J., Fellay, J., Francini, K., Furrer, H., Fux, C. A., Grawe, C., Gunthard, H. F., Haerry, D., Hasse, B., Hirsch, H. H., Hoffmann, M., Hosli, I, Huber, M., Kahlert, C. R., Kaiser, L., Keiser, O., Klimkait, T., Kottanattu, L., Kouyos, R. D., Kovari, H., Ledergerber, B., Martinetti, G., de Tejada, Martinez B., Marzolini, C., Metzner, K. J., Mueller, N., Nicca, D., Paioni, P., Pantaleo, G., Perreau, M., Polli, Ch, Rauch, A., Rudin, C., Scherrer, A. U., Schmid, P., Speck, R., Stockle, M., Tarr, P., Lecompte, Thanh M., Trkola, A., Vernazza, P., Wagner, N., Wandeler, G., Weber, R., Wyler, C. A., Yerly, S., Wannarit, Pornpun, Techakunakorn, Pornchai, Hansudewechakul, Rawiwan, Wanchaitanawong, Vanichaya, Theansavettrakul, Sookchai, Nanta, Sirisak, Ngampiyaskul, Chaiwat, Phanomcheong, Siriluk, Hongsiriwon, Suchat, Karnchanamayul, Warit, Kwanchaipanich, Ratchanee, Kanjanavanit, Suparat, Kamonpakorn, Nareerat, Nantarukchaikul, Maneeratn, Layangool, Prapaisri, Mekmullica, Jutarat, Lucksanapisitkul, Paiboon, Watanayothin, Sudarat, Lertpienthum, Narong, Warachit, Boonyarat, Hanpinitsak, Sansanee, Potchalongsin, Sathit, Thanasiri, Pimpraphai, Krikajornkitti, Sawitree, Attavinijtrakarn, Pornsawan, Srirojana, Sakulrat, Bunjongpak, Suthunya, Puangsombat, Achara, Na-Rajsima, Sathaporn, Ananpatharachai, Pornchai, Akarathum, Noppadon, Lawtongkum, Weerasak, An, Prapawan Kheunj, Suriyaboon, Thitiporn, Saipanya, Airada, Than-in-at, Kanchana, Jaisieng, Nirattiya, Suaysod, Rapeepan, Chailoet, Sanuphong, Naratee, Naritsara, Kawilapat, Suttipong, Lyall, Hermione, Bamford, Alasdair, Butler, Karim, Doherty, Conor, Foster, Caroline, Francis, Kate, Harrison, Ian, Kenny, Julia, Klein, Nigel, Letting, Gillian, McMaster, Paddy, Murau, Fungai, Nsangi, Edith, Peters, Helen, Prime, Katia, Riordan, Andrew, Shackley, Fiona, Shingadia, Delane, Storey, Sharon, Tudor-Williams, Gareth, Turkova, Anna, Welch, Steve, Collins, Intira Jeannie, Cook, Claire, Dobson, Donna, Fairbrother, Keith, Harper, Lynda, Le Prevost, Marthe, Van Looy, Nadine, Butler, K., Walsh, A., Thrasyvoulou, L., Welch, S., Bernatoniene, J., Manyika, F., Sharpe, G., Subramaniam, B., Sloper, K., Fidler, K., Hague, R., Price, V, Clapson, M., Flynn, J., Abou-Rayyah, A. Cardoso M., Klein, N., Shingadia, D., Gurtin, D., Yeadon, S., Segal, S., Ball, C., Hawkins, S., Dowie, M., Bandi, S., Percival, E., Eisenhut, M., Duncan, K., Clough, S., Anguvaa, L., Conway, S., Flood, T., Pickering, A., Murphy, P. McMaster C., Daniels, J., Lees, Y., Thompson, F., Williams, B., Pope, S., Cliffe, L., Smyth, A., Southall, S., Freeman, A., Freeman, H., Christie, S., Gordon, A., Clarke, D. Rogahn L., Jones, L., Offerman, B., Greenberg, M., Benson, C., Riordan, A., Ibberson, L., Shackley, F., Faust, S. N., Hancock, J., Doerholt, K., Prime, K., Sharland, M., Storey, S., Lyall, H., Monrose, C., Seery, P., Tudor-Williams, G., Menson, E., Callaghan, A., Bridgwood, A., McMaster, P., Evans, J., Blake, E., Yannoulias, A., European Pregnancy Paediat HIV Coh, Microbes in Health and Disease (MHD), Fundación Investigación y Educación en Sida, Instituto de Salud Carlos III, European Commission, Fundación Mutua Madrileña, Épidémiologie clinique, santé mère-enfant et VIH en Asie du Sud-Est (IRD_PHPT), Harvard University [Cambridge]-Chiang Mai University (CMU), Pediatrics, and Virology

Subjects
0301 basic medicine, Male, Pediatrics, puberty, [SDV]Life Sciences [q-bio], humanos, Human immunodeficiency virus (HIV), adolescente, LETTONIE, CHILDREN, HIV Infections, medicine.disease_cause, GRECE, desarrollo del niño, Cohort Studies, 0302 clinical medicine, Child Development, CHILD_DEVELOPMENT, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, ADOLESCENTS, Immunology and Allergy, Pooled data, 030212 general & internal medicine, SUEDE, Child, estudios de cohortes, ESPAGNE, 11 Medical and Health Sciences, Anthropometry, THAILANDE, Europe, growth, height, HIV, perinatal, Thailand, Adolescent, Anti-Retroviral Agents, Child, Preschool, Female, Humans, Infant, Puberty, virus diseases, Growth spurt, PAYS BAS, 3. Good health, 17 Psychology and Cognitive Sciences, AIDS, antirretrovirales, Infectious Diseases, POLOGNE, BELGIQUE, Life Sciences & Biomedicine, medicine.medical_specialty, Pediatric hiv, Epidemiology and Social, ROYAUME UNI, Immunology, MASS, European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) study group, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Virology, medicine, pubertad, Preschool, lactante, ROUMANIE, Science & Technology, business.industry, 06 Biological Sciences, VELOCITY, SUISSE, Regimen, 030104 developmental biology, VIRAL LOAD, antropometría, infecciones por VIH, BODY_HEIGHT, business, IRLANDE, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

The European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) study group., [Objective]: The aim of this study was to describe growth during puberty in young people with vertically acquired HIV. [Design]: Pooled data from 12 paediatric HIV cohorts in Europe and Thailand. [Methods]: One thousand and ninety-four children initiating a nonnucleoside reverse transcriptase inhibitor or boosted protease inhibitor based regimen aged 1–10 years were included. Super Imposition by Translation And Rotation (SITAR) models described growth from age 8 years using three parameters (average height, timing and shape of the growth spurt), dependent on age and height-for-age z-score (HAZ) (WHO references) at antiretroviral therapy (ART) initiation. Multivariate regression explored characteristics associated with these three parameters. [Results]: At ART initiation, median age and HAZ was 6.4 [interquartile range (IQR): 2.8, 9.0] years and −1.2 (IQR: −2.3 to −0.2), respectively. Median follow-up was 9.1 (IQR: 6.9, 11.4) years. In girls, older age and lower HAZ at ART initiation were independently associated with a growth spurt which occurred 0.41 (95% confidence interval 0.20–0.62) years later in children starting ART age 6 to 10 years compared with 1 to 2 years and 1.50 (1.21–1.78) years later in those starting with HAZ less than −3 compared with HAZ at least −1. Later growth spurts in girls resulted in continued height growth into later adolescence. In boys starting ART with HAZ less than −1, growth spurts were later in children starting ART in the oldest age group, but for HAZ at least −1, there was no association with age. Girls and boys who initiated ART with HAZ at least −1 maintained a similar height to the WHO reference mean. [Conclusion]: Stunting at ART initiation was associated with later growth spurts in girls. Children with HAZ at least −1 at ART initiation grew in height at the level expected in HIV negative children of a comparable age., This work has been partially funded by the Fundación para la Investigación y Prevención de SIDA en España (FIPSE) (FIPSE 3608229/09, FIPSE 240800/09, FIPSE 361910/10), Red Temática de Investigación en SIDA (RED RIS) supported by Instituto de Salud Carlos III (ISCIII) (RD12/0017/0035 and RD12/0017/0037), project as part of the Plan R+D+I and cofinanced by ISCIII- Subdirección General de Evaluación and Fondo Europeo de Desarrollo Regional (FEDER),Mutua Madrileña 2012/0077, Gilead Fellowship 2013/0071, FIS PI15/00694,CoRISpe (RED RIS RD06/0006/0035 y RD06/0006/0021).

Published
2019

4. Predictors of faster virological suppression in early treated infants with perinatal HIV from Europe and Thailand

Author

Chan, Man K., Goodall, Ruth, Judd, Ali, Klein, Nigel, Chiappini, Elena, Klimkait, Thomas, Ngo-Giang-Huong, Nicole, Palma, Paolo, Rossi, Paolo, Thorne, Claire, Turkova, Anna, Zangari, Paola, Fraaij, Pieter L., Pajkrt, Dasja, Marques, Laura, Collins, Intira J., Gibb, Diana M., Gonzalez-Tome, Maria I., Navarro, Maria L., Ramos, Jose T., Noguera-Julian, Antoni, Warszawski, Josiane, Königs, Christoph, Spoulou, Vana, Prata, Filipa, Goetghebuer, Tessa, Galli, Luisa, Naver, Lars, Giaquinto, Carlo, Marczynska, Magdalena, Okhonskaia, Liubov, Malyuta, Ruslan, Volokha, Alla, Ene, Luminita, Rojo, Pablo, and Babiker, Abdel G. A.

Subjects
Male, 0301 basic medicine, Pediatrics, Sustained Virologic Response, Sida en l'embaràs, HIV Infections, Cohort Studies, 0302 clinical medicine, immune system diseases, Interquartile range, Antiretroviral Therapy, Highly Active, Immunology and Allergy, 030212 general & internal medicine, infants, Hazard ratio, Age Factors, virus diseases, Viral Load, Clinical Science, Thailand, 3. Good health, Europe, Infectious Diseases, Cohort, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Disease Progression, Reverse Transcriptase Inhibitors, Female, Viral load, virological suppression, Cohort study, Cart, medicine.medical_specialty, Immunology, Drug Administration Schedule, 03 medical and health sciences, mental disorders, medicine, VIH (Virus), Humans, early combination antiretroviral therapy, Pregnancy, Proportional hazards model, business.industry, HIV (Viruses), Infant, Newborn, Infant, HIV Protease Inhibitors, medicine.disease, CD4 Lymphocyte Count, AIDS (Disease) in pregnancy, predictors, 030104 developmental biology, nervous system, Drug withdrawal symptoms, Multivariate Analysis, Síndrome d'abstinència, business, perinatal HIV
Abstract

Supplemental Digital Content is available in the text, Objective: To identify predictors of faster time to virological suppression among infants starting combination antiretroviral therapy (cART) early in infancy. Design: Cohort study of infants from Europe and Thailand included in studies participating in the European Pregnancy and Paediatric HIV Cohort Collaboration. Methods: Infants with perinatal HIV starting cART aged less than 6 months with at least 1 viral load measurement within 15 months of cART initiation were included. Multivariable interval-censored flexible parametric proportional hazards models were used to assess predictors of faster virological suppression, with timing of suppression assumed to lie in the interval between last viral load at least 400 and first viral load less than 400 copies/ml. Results: Of 420 infants, 59% were female and 56% from Central/Western Europe, 26% United Kingdom/Ireland, 15% Eastern Europe and 3% Thailand; 46 and 54% started a boosted protease inhibitor-based or nonnucleoside reverse transcriptase inhibitor-based regimen, respectively. At cART initiation, the median age, CD4+% and viral load were 2.9 [interquartile range (IQR): 1.4–4.1] months, 34 (IQR: 24–45)% and 5.5 (IQR: 4.5–6.0) log10 copies/ml, respectively. Overall, an estimated 89% (95% confidence interval: 86–92%) achieved virological suppression within 12 months of cART start. In multivariable analysis, younger age [adjusted hazard ratio (aHR): 0.84 per month older; P

Published
2019

5. Long-term trends in mortality and AIDS-defining events after combination ART initiation among children and adolescents with perinatal HIV infection in 17 middle- and high-income countries in Europe and Thailand : a cohort study

Author

Judd, Ali, Chappell, Elizabeth, Turkova, Anna, Le Coeur, Sophie, Noguera-Julian, Antoni, Goetghebuer, Tessa, Doerholt, Katja, Galli, Luisa, Pajkrt, Dasja, Marques, Laura, Collins, Intira J., Gibb, Diana M., González Tome, Maria Isabel, Navarro, Marisa, Warszawski, Josiane, Königs, Christoph, Spoulou, Vana, Prata, Filipa, Chiappini, Elena, Naver, Lars, Giaquinto, Carlo, Thorne, Claire, Marczynska, Magdalena, Okhonskaia, Liubov, Posfay-Barbe, Klara, Ounchanum, Pradthana, Techakunakorn, Pornchai, Kiseleva, Galina, Malyuta, Ruslan, Volokha, Alla, Ene, Luminita, Goodall, Ruth, Deeks, Steven G., The European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) study group in EuroCoord, AII - Infectious diseases, ARD - Amsterdam Reproduction and Development, Paediatric Infectious Diseases / Rheumatology / Immunology, AII - Amsterdam institute for Infection and Immunity, and Institut national d'études démographiques (INED)

Subjects
RNA viruses, Viral Diseases, [SDV]Life Sciences [q-bio], HIV Infections, Infant mortality, Pathology and Laboratory Medicine, Adolescents, Geographical Locations, Cohort Studies, Families, Immunodeficiency Viruses, Risk Factors, Medicine and Health Sciences, Public and Occupational Health, Child, Children, ddc:618, Medicine (all), virus diseases, Viral Load, Thailand, Vaccination and Immunization, AIDS, Europe, Infectious Diseases, Anti-Retroviral Agents, Medical Microbiology, Viral Pathogens, Child, Preschool, Viruses, Disease Progression, Drug Therapy, Combination, Pathogens, Research Article, Adolescent, Death Rates, Biochimie, Immunology, Biotechnologie, Antiretroviral Therapy, [SHS.DEMO]Humanities and Social Sciences/Demography, Microbiology, Immune Suppression, Acquired Immunodeficiency Syndrome, Humans, Infant, Infant, Newborn, Signs and Symptoms, Population Metrics, Antiviral Therapy, Diagnostic Medicine, Virology, Retroviruses, VIH (Virus), ddc:610, Mortality, Microbial Pathogens, Population Biology, HIV (Viruses), Lentivirus, Organisms, Biology and Life Sciences, Biologie moléculaire, HIV, Age Groups, People and Places, Population Groupings, Biologie cellulaire, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Preventive Medicine, Viral Transmission and Infection, Mortalitat infantil
Abstract

Background: Published estimates of mortality and progression to AIDS as children with HIV approach adulthood are limited. We describe rates and risk factors for death and AIDS-defining events in children and adolescents after initiation of combination antiretroviral therapy (cART) in 17 middle- and high-income countries, including some in Western and Central Europe (W&CE), Eastern Europe (Russia and Ukraine), and Thailand. Methods and findings: Children with perinatal HIV aged 6 months of cART) death and progression to AIDS were assessed. Of 3,526 children included, 32% were from the United Kingdom or Ireland, 30% from elsewhere in W&CE, 18% from Russia or Ukraine, and 20% from Thailand. At cART initiation, median age was 5.2 (IQR 1.4–9.3) years; 35% of children aged 400 c/mL predicted late death. Predictors of early and late progression to AIDS were similar. Study limitations include incomplete recording of US Centers for Disease Control (CDC) disease stage B events and serious adverse events in some countries; events that were distributed over a long time period, and that we lacked power to analyse trends in patterns and causes of death over time. Conclusions: In our study, 3,526 children and adolescents with perinatal HIV infection initiated antiretroviral therapy (ART) in countries in Europe and Thailand. We observed that over 40% of deaths occurred ≤6 months after cART initiation. Greater early mortality risk in infants, as compared to older children, and in Russia, Ukraine, or Thailand as compared to W&CE, raises concern. Current severe immune suppression, being underweight, and unsuppressed viral load were associated with a higher risk of death at >6 months after initiation of cART., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2018

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