1. Multimodal soft tissue markers for bridging high-resolution diagnostic imaging with therapeutic intervention
- Author
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Thomas Eriksen, Steen Riisgaard de Blanck, Mads Hartvig Clausen, Merete B. Christensen, Anders Elias Hansen, Jonas Rosager Henriksen, Linda Maria Bruun, Rasmus Irming Jølck, Klaus Larsen, Andreas Kjaer, Andreas Tue Ingemann Jensen, Niels Erik Viby, Jonas Scherman, Thomas Lars Andresen, Frederikke P. Fliedner, Fintan J. McEvoy, Lilah Moorman, Paul Frost Clementsen, Knut Conradsen, Gitte Persson, Anders Christensen, Rasmus Larsen, Paul J. Kempen, Per Munck af Rosenschöld, Wenbo Wang, and Sorel Kurbegovic
- Subjects
Bridging (networking) ,InformationSystems_INFORMATIONINTERFACESANDPRESENTATION(e.g.,HCI) ,ComputingMethodologies_SIMULATIONANDMODELING ,Radiography ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,High resolution ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Fiducial Markers ,medicine ,Medical imaging ,Robotic surgery ,Health and Medicine ,Research Articles ,Multidisciplinary ,medicine.diagnostic_test ,business.industry ,Phantoms, Imaging ,Ultrasound ,Soft tissue ,SciAdv r-articles ,Magnetic resonance imaging ,Magnetic Resonance Imaging ,Applied Sciences and Engineering ,Needles ,030220 oncology & carcinogenesis ,business ,Biomedical engineering ,Research Article ,Radiotherapy, Image-Guided - Abstract
The liquid-based Carbo-gel technology enables real-time multimodal image guidance for improved therapeutic precision., Diagnostic imaging often outperforms the surgeon’s ability to identify small structures during therapeutic procedures. Smart soft tissue markers that translate the sensitivity of diagnostic imaging into optimal therapeutic intervention are therefore highly warranted. This paper presents a unique adaptable liquid soft tissue marker system based on functionalized carbohydrates (Carbo-gel). The liquid state of these markers allows for high-precision placement under image guidance using thin needles. Based on step-by-step modifications, the image features and mechanical properties of markers can be optimized to bridge diagnostic imaging and specific therapeutic interventions. The performance of Carbo-gel is demonstrated for markers that (i) have radiographic, magnetic resonance, and ultrasound visibility; (ii) are palpable and visible; and (iii) are localizable by near-infrared fluorescence and radio guidance. The study demonstrates encouraging proof of concept for the liquid marker system as a well-tolerated multimodal imaging marker that can improve image-guided radiotherapy and surgical interventions, including robotic surgery.
- Published
- 2020