28,928 results
Search Results
2. Tuberculosis Diagnosis Using Isothermal Nucleic Acid Amplification in a Paper-and-Plastic Device
- Author
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Navjot Kaur and Bhushan J. Toley
- Published
- 2023
3. Loop-Mediated Isothermal Amplification on Paper Microfluidic Chips for Highly Sensitive and Specific Zika Virus Detection Using Smartphone
- Author
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Kattika Kaarj and Jeong-Yeol Yoon
- Published
- 2023
4. Measurement invariance between online and paper-and-pencil formats of the Launay-Slade Hallucinations scale-extended (LSHS-E) in the Chilean population
- Author
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Quijada, Yanet, Saldivia, Sandra, Bustos, Claudio, Preti, Antonio, Ochoa, Susana, Castro-Alzate, Elvis, and Siddi, Sara
- Subjects
Proneness to hallucination ,Psychometric properties ,Multisensory hallucinations ,Article ,Confirmatory factor analysis ,Measurement invariance - Abstract
Research on the multidimensionality of hallucination-like experiences (HLEs) can contribute to the study of psychotic risk. The Launay-Slade Hallucinations Scale-Extended (LSHS-E) is one of the most widely used tools for research in HLEs, but the correspondence of its paper and online formats has not been established yet. Therefore, we studied the factorial structure and measurement invariance between online and paper-and-pencil versions of LSHS-E in a Chilean population. Two thousand eighty-six completed the online version, and 578 students completed the original paper-and-pencil version. After matching by sex, age, civil status, alcohol and cannabis consumption, and psychiatric treatment received, we selected 543 students from each group. We conducted a confirmatory factor analysis of a four-factor model and a hierarchical model that included a general predisposition to hallucination, explaining the strong relationship between the different types of hallucinations. Both models showed a good fit to the data and were invariant between paper-and-pencil and online versions. Also, the LSHS-E has good reliability in both online and paper-and-pencil formats. This study shows that the online LSHS-E possesses psychometric properties equivalent to the paper-and-pencil version. It should be considered a valuable tool for research of psychosis determinants in the COVID-19 era. Supplementary Information The online version contains supplementary material available at 10.1007/s12144-021-02497-7.
- Published
- 2022
5. ATP Sensing Paper with Smartphone Bioluminescence-Based Detection
- Author
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Calabretta, Maria Maddalena, Álvarez-Diduk, Ruslan, Michelini, Elisa, Merkoçi, Arben, Ministero dell'Istruzione, dell'Università e della Ricerca, European Commission, Generalitat de Catalunya, Ministerio de Ciencia, Innovación y Universidades (España), and Agencia Estatal de Investigación (España)
- Subjects
Bioluminescence (BL) ,Smartphone detection ,Adenosine-5′-triphosphate (ATP) ,Freeze-dry technology ,Luciferase ,ATP sensing paper ,Paper sensing - Abstract
Adenosine-5'-triphosphate (ATP) is the primary energy carrier in all living organisms, and its detection in living cells represents a well-established approach. ATP-driven bioluminescence (BL) relying on the D-luciferin-luciferase reaction is a bioanalytical tool widely employed for monitoring hygiene and microbial contamination of foods.Here, we report a straightforward method for ATP BL detection using an ATP sensing paper fabricated with an alternative freeze-dry procedure. The assay can be easily implemented in laboratories equipped with (i) freeze-drying, wax printing, and 3D printing technologies and (ii) instrumentation for BL detection such as benchtop luminometers and portable light detectors including a smartphone camera without the need for additional equipment., Elisa Michelini acknowledges support by MIUR and Prima (Partnership for Research and Innovation in the Mediterranean Area) with FEDKITO project. ICN2 is funded by CERCA programme, Generalitat de Catalunya. Grant SEV-2017-0706 funded by MCIN/AEI/10.13039/501100011033.
- Published
- 2022
6. Detection of Avocado Sunblotch and Other Viroids Using RNA Filter Paper Capture and RT-PCR
- Author
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James A. Heick, D. M. Mathews, J. Allan Dodds, and Sohrab Bodaghi
- Subjects
biology ,Filter paper ,Chemistry ,viruses ,Sterile water ,food and beverages ,RNA ,biology.organism_classification ,Horticulture ,Avocado sunblotch viroid ,Chrysanthemum stunt viroid ,Standard protocol ,Peach latent mosaic viroid ,Potato spindle tuber viroid - Abstract
This method originated due to the need to quickly and sensitively detect Avocado sunblotch viroid (ASBVd) in nursery and field trees in California. Optimum sampling protocols were developed for leaf collection from different sized trees based on size and branching as well as for fruit. An ethanol containing buffered extract from 1 g of ground leaf tissue was used as the source of RNA. The extract was absorbed onto small pieces (disks) of Whatman No. 1 filter paper which were then washed and dried. RNA was eluted from the filter paper using sterile water and used as a template in a standard single-tube RT-PCR reaction. The RNA adsorbed on the filter paper disks was quite stable, and the disks could be stored for over 1 year and shipped worldwide at ambient temperature with no noticeable decline in the quality or quantity of the resulting RT-PCR products. The filter paper capture method was expanded to the detection of other viroids including Potato spindle tuber viroid, Peach latent mosaic viroid, and Chrysanthemum stunt viroid and was tested with some viruses as well with minor modifications of the standard protocol.
- Published
- 2021
7. New Insulating Fluids and Diagnostic Techniques for Paper-Oil Insulated Equipment1
- Author
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S. M. Korobeinikov, A. A. Konovalov, and M. N. Lyutikova
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Engineering management ,Engineering ,esters ,48th CIGRE session ,business.industry ,Energy Engineering and Power Technology ,diagnostic technique for high-voltage equipment ,Session (computer science) ,business ,Energy sector ,Environmentally friendly ,Article ,liquid dielectrics - Abstract
In 2021, the International Council on Large Electric Systems (CIGRE) will celebrate its centenary. CIGRE Sessions are traditionally held face-to-face in Paris once every even-numbered year. However, in 2020, in response to the coronavirus pandemic, the organizers of the 48th CIGRE Session decided to hold a virtual meeting for experts, specialists, engineers, and researchers from all over the world. The result was an e-session that included engaging seminars, tutorials, and discussions. At the virtual meeting, participants discussed various problems and challenges currently affecting all areas of the energy sector. Current pressing issues include the development of informative diagnostic techniques for oil-filled equipment, as well as the potential applicability of environmentally friendly biodegradable synthetic and natural esters for use as liquid insulation in high-voltage equipment. This review presents the latest research, practical solutions and reports on the experience of applying new techniques and novel liquid insulating materials. Valuable and up-to-date information in these fields is provided by experts and specialists from all over the world.
- Published
- 2021
8. Angiotensin receptor-neprilysin inhibition in patients with acute decompensated heart failure: an expert consensus position paper
- Author
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John Kanakakis, John Parissis, Sotirios Patsilinakos, Grigorios Giamouzis, Christina Chrysohoou, Aikaterini Naka, Dimitrios Tziakas, Apostolos Karavidas, Constantinos Papadopoulos, Argyrios Ntalianis, and George Giannakoulas
- Subjects
medicine.medical_specialty ,Angiotensins ,Consensus ,Acute decompensated heart failure ,030204 cardiovascular system & hematology ,Sacubitril ,Article ,03 medical and health sciences ,Angiotensin Receptor Antagonists ,0302 clinical medicine ,medicine ,Humans ,Multicenter Studies as Topic ,030212 general & internal medicine ,Enalapril ,Sacubitril/valsartan ,Prospective Studies ,Intensive care medicine ,Randomized Controlled Trials as Topic ,Heart Failure ,Receptors, Angiotensin ,business.industry ,Aminobutyrates ,Biphenyl Compounds ,Acute heart failure ,Stroke Volume ,medicine.disease ,Hospitalization ,Treatment Outcome ,Valsartan ,Heart failure ,Biomarker (medicine) ,Observational study ,Neprilysin ,Cardiology and Cardiovascular Medicine ,business ,Sacubitril, Valsartan ,medicine.drug - Abstract
The short-term mortality and rehospitalization rates after admission for acute heart failure (AHF) remain high, despite the high level of adherence to contemporary practice guidelines. Observational data from non-randomized studies in AHF strongly support the in-hospital administration of oral evidence-based modifying chronic heart failure (HF) medications (i.e., b-blockers, ACE inhibitors, mineralocorticoid receptor antagonists) to reduce morbidity and mortality. Interestingly, a well-designed prospective randomized multicenter study (PIONEER-HF) showed an improved clinical outcome and stress/injury biomarker profile after in-hospital administration of sacubitril/valsartan (sac/val) as compared to enalapril, in hemodynamically stable patients with AHF. However, sac/val implementation during hospitalization remains suboptimal due to the lack of an integrated individualized plan or well-defined appropriateness criteria for transition to oral therapies, an absence of specific guidelines regarding dose selection and the up-titration process, and uncertainty regarding patient eligibility. In the present expert consensus position paper, clinical practical recommendations are proposed, together with an action plan algorithm, to encourage and facilitate sac/val administration during hospitalization after an AHF episode with the aim of improving efficiencies of care and resource utilization.
- Published
- 2021
9. Detection of Norovirus Using Paper-Based Cell-Free Systems
- Author
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Kaiyue Wu and Alexander A. Green
- Published
- 2022
10. Cell-Free Paper-Based Analysis of Gut Microbiota and Host Biomarkers
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Melissa K. Takahashi, Xiao Tan, and Aaron J. Dy
- Published
- 2022
11. Application of Paper Spray Ionization for Preliminary Amazonian Berry Fruits Components Identification
- Author
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Luiz Paulo Morais de Oliveira, Débora de Sena Raposo, Luciana dos Santos Ipiranga Rodrigues, Silvio Oliveira Assunção Junior, Francinaldo Araujo da Silva-Filho, Bruna Ribeiro de Lima, Emmanoel Vilaça Costa, Afonso Duarte Leão de Souza, Hector Henrique Ferreira Koolen, and Felipe Moura Araujo da Silva
- Published
- 2022
12. On-substrate Enzymatic Reaction to Determine Acetylcholinesterase Activity in Whole Blood by Paper Spray Mass Spectrometry
- Author
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Daniel O. Carmany, Ethan M. McBride, Paul S. Demond, Bernard J. Benton, Elizabeth S. Dhummakupt, Gabrielle M. Rizzo, Phillip M. Mach, Jennifer W. Sekowski, Michael W. Busch, and Trevor Glaros
- Subjects
Paper ,Aché ,010402 general chemistry ,Mass spectrometry ,01 natural sciences ,Acetylcholinesterase assay ,VX ,Mass Spectrometry ,chemistry.chemical_compound ,Piperidines ,Structural Biology ,medicine ,Humans ,Spectroscopy ,Whole blood ,Nerve agent ,Enzyme Assays ,chemistry.chemical_classification ,Chromatography ,Paper spray ,010401 analytical chemistry ,Acetylcholinesterase ,language.human_language ,0104 chemical sciences ,Enzyme ,chemistry ,language ,Substrate specificity ,Toxicant ,medicine.drug ,Research Article - Abstract
Currently, all assays measuring acetylcholinesterase (AChE) activity following a suspected nerve agent exposure leverage methodologies that fail to identify the agent. This limits the overall effectiveness and ability to administer proper countermeasures. As such, there is an urgent need to identify novel, rapid, and more comprehensive approaches to establish AChE activity, including identification of the toxicant. Paper spray mass spectrometry was used to monitor the activity of acetylcholinesterase, both in-solution and on modified hydrophobic paper surface. Hydrophobic paper surfaces were prepared using vaporized trichloro(3,3,3-trifluoropropyl)silane. In both approaches, mixtures of diluted human whole blood with and without VX were mixed with a non-endogenous AChE specific substrate, 1,1-dimethyl-4-acetylthiomethylpiperidinium (MATP+). Formation of the cleaved MATP+ product was monitored over time and compared to MATP+ to determine relative AChE activity. This on-substrate assay was effective at determining AChE activity and identifying the toxicant; however, determination of AChE activity in-solution proceeded at a slower rate. The on-substrate assay serves as a pioneering example of an enzymatic reaction occurring on the surface of a paper spray ionization ticket. This work broadens the range of applications relating to paper spray ionization-based clinical diagnostic assays. Graphical Abstractᅟ Electronic supplementary material The online version of this article (10.1007/s13361-018-2072-1) contains supplementary material, which is available to authorized users.
- Published
- 2018
13. Nano-Silver Ink of High Conductivity and Low Sintering Temperature for Paper Electronics
- Author
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Zhiqing Xin, Qingqing Zhang, Cao Meijuan, Yinjie Chen, Zhenguo Wang, Xiu Li, Li Luhai, Lixin Mo, Li Yang, Zhenxin Guo, and Yi Fang
- Subjects
Coated paper ,Materials science ,Nano Express ,Sintering ,Nanochemistry ,Low sintering temperature ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Flexible and printed electronics ,0104 chemical sciences ,Nano-silver ,Surface coating ,Paper electronics ,Chemical engineering ,Electrical resistivity and conductivity ,Printed electronics ,Conductive ink ,lcsh:TA401-492 ,General Materials Science ,lcsh:Materials of engineering and construction. Mechanics of materials ,Particle size ,0210 nano-technology - Abstract
Highly conductive ink with low sintering temperature is important for printed electronics on paper substrate. Silver nanoparticles (Ag NPs) of different average radii ranging from 48 to 176 nm were synthesized by adjusting the Ag+ concentration in the reaction process. The electric resistivity of the Ag NP-based ink film in relation to Ag NP size, sintering temperature, amount of PVP capping agent on Ag NP surface, and morphology evolution of the film during heating process was investigated. It was found that the resistivity of the films reduced very rapidly with increasing particle size due above all to reduced amount of protective agent capping on the Ag NPs. A semi-empirical relationship between the resistivity and the particle size was proposed. With the help of this mathematical expression, one gains both systematic and detailed insight to the resistivity evaluation with regard to the Ag particle size. The optimal electric resistivity of 4.6 μΩ cm was achieved at 140 °C for 10 min which was very close to the resistivity value of bulk Ag (1.58 μΩ cm). Mechanical flexibility of the printed electronics with the Ag NP-based ink on paper substrates was investigated. The prints on the art coated paper exhibited better flexibility compared to that on the photopaper. This might be attributed to the surface coating composition, surface morphology of the paper, and their corresponding ink absorption property. Electronic supplementary material The online version of this article (10.1186/s11671-019-3011-1) contains supplementary material, which is available to authorized users.
- Published
- 2019
14. Flexible Photocatalytic Paper with Cu2O and Ag Nanoparticle-Decorated ZnO Nanorods for Visible Light Photodegradation of Organic Dye
- Author
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Cheng-En Tsai, Chienhua Chen, Heh-Nan Lin, and Shang-Ming Yeh
- Subjects
Materials science ,Nanochemistry ,Nanoparticle ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,chemistry.chemical_compound ,Rhodamine B ,lcsh:TA401-492 ,General Materials Science ,Photocatalysis ,Photodegradation ,ZnO nanorod ,Nanocomposite ,Nano Express ,Photocatalytic paper ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Cu2O nanoparticle ,0104 chemical sciences ,chemistry ,Chemical engineering ,Nanorod ,lcsh:Materials of engineering and construction. Mechanics of materials ,0210 nano-technology ,Ag nanoparticle ,Visible spectrum - Abstract
We report on the fabrication of flexible photocatalytic paper comprised of Cu2O and Ag nanoparticle (NP)-decorated ZnO nanorods (NRs) and its application in visible light photodegradation of organic dye. ZnO NRs are first grown on a kraft paper substrate using a hydrothermal method. The NRs are subsequently decorated with Cu2O, Ag, or both NPs formed by photoreduction processes. Scanning electron microscopy and X-ray diffraction analysis confirm the crystallinity of ZnO NRs. Transmission electron microscopy analysis confirms the compositions of the two types of NPs. Four different types of photocatalytic papers with a size of 10 × 10 cm2 are prepared and used to degrade a 10-μM and 100-mL rhodamine B solution. The paper with Cu2O and Ag NP-co-decorated ZnO NRs has the best efficiency with first-order kinetic constants of 0.017 and 0.041 min−1 under the illumination of a halogen lamp and direct sunlight, respectively. The performance of the photocatalytic paper compares well with other substrate-supported ZnO nanocomposite photocatalysts. With the advantages of flexibility, light weight, nontoxicity, low cost, and ease of fabrication, the photocatalytic paper has good potential for visible light photocatalysis.
- Published
- 2019
15. Paper Chromatography of Amino Acid
- Author
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Sourabh Jain, Aakanchha Jain, and Richa Jain
- Subjects
chemistry.chemical_classification ,Paper chromatography ,Chromatography ,chemistry ,Amino acid - Published
- 2020
16. Paper Chromatography of Carbohydrates
- Author
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Aakanchha Jain, Richa Jain, and Sourabh Jain
- Subjects
Paper chromatography ,Chromatography ,Chemistry - Published
- 2020
17. The paper chase and the big data arms race
- Author
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Carol Lynn Curchoe
- Subjects
medicine.medical_specialty ,business.industry ,Arms race ,Big data ,Reproductive medicine ,MEDLINE ,Obstetrics and Gynecology ,General Medicine ,Fertilization in Vitro ,Human genetics ,Reproductive Medicine ,Artificial Intelligence ,Family medicine ,Genetics ,medicine ,Commentary ,Humans ,business ,Psychology ,Genetics (clinical) ,Developmental Biology ,Data Management - Published
- 2021
18. Special Issue Focus: Selected Papers from the 5th Symposium on Damage Mechanism in Materials and Structures
- Author
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Shahrum Abdullah and Salvinder Singh Karam Singh
- Subjects
Focus (computing) ,Mechanics of Materials ,Computer science ,Management science ,Mechanical Engineering ,Solid mechanics ,General Materials Science ,Guest Editorial ,Safety, Risk, Reliability and Quality ,Mechanism (sociology) - Published
- 2021
19. Smartphone-Based Paper Microfluidic Immunoassay of Salmonella and E. coli
- Author
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Laurel Dieckhaus, Tusan Park, and Jeong Yeol Yoon
- Subjects
Detection limit ,Salmonella ,010304 chemical physics ,Channel (digital image) ,biology ,medicine.diagnostic_test ,Computer science ,010401 analytical chemistry ,Microfluidics ,Pipette ,medicine.disease_cause ,biology.organism_classification ,01 natural sciences ,0104 chemical sciences ,Standard curve ,Microfluidic chip ,Immunoassay ,0103 physical sciences ,medicine ,Biological system ,Bacteria - Abstract
Previous studies from our lab have created a simple procedure for single-cell count of bacteria on a paper chip platform using optical detection from a smartphone. The procedure and steps employed are outlined along with the lessons learned and details of certain steps and how the design was optimized. Smartphone optical detection is easy to use, low cost, and potentially field deployable, which can be useful for early and rapid detection of pathogens. Smartphone imaging of a paper microfluidic chip preloaded with antibody-conjugated particles provides an adaptable platform for detection of different bacterial targets. The paper microfluidic chip was fabricated with a multichannel design. Each channel was preloaded with either a negative control of bovine serum albumin (BSA) conjugated particles, anti-Salmonella Typhimurium-conjugated particles with varying amounts (to cover different ranges of assay), or anti-Escherichia coli-conjugated particles. Samples were introduced to the paper microfluidic chip using pipetting. Antigens of Salmonella Typhimurium traveled through the channel by capillary action confined within the paper fibers surrounded by the hydrophobic barrier. The paper channel was observed to act as a filter for unwanted particles and contaminants found in field samples. Serial dilutions of known concentrations of bacterial targets were also tested using this procedure to construct a standard curve prior to the assays. The antibody-conjugated particles were able to immunoagglutinate which was quantified through evaluation of Mie scatter intensity. This Mie scattering was quantified in images taken with a smartphone at an optimized angle and distance. Mie scatter simulation provided a method of optimizing the experimental setup and could translate easily to other types of target sample matrices. A smartphone application was developed to help the user position the smartphone optimally in relation to the paper microfluidic chip. The application integrated both image capturing capability and a simple image processing algorithm that calculated bacteria concentrations. The detection limit was at a single-cell level with a total assay time ranging from 90 to less than 60 s depending on the target.
- Published
- 2020
20. The Advent of Studies on Jaw Cysts with Keratinization: A Review of Overlooked Papers on Odontogenic Keratocyst and Orthokeratinized Odontogenic Cyst
- Author
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Fumio Ide, Kentaro Kikuchi, Kaoru Kusama, Takashi Muramatsu, Yuji Miyazaki, Michiko Nishimura, and Yumi Ito
- Subjects
0301 basic medicine ,Orthokeratinized odontogenic cyst ,medicine.medical_specialty ,Pathology ,History ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Historical Perspectives in Pathology ,Humans ,Cyst ,Keratocyst ,General surgery ,History, 19th Century ,Epidermoid cyst ,Jaw cyst ,History, 20th Century ,medicine.disease ,Odontogenic ,030104 developmental biology ,Oncology ,Otorhinolaryngology ,Dermoid cyst ,030220 oncology & carcinogenesis ,Odontogenic Cysts ,medicine.symptom ,Jaw Diseases - Abstract
Previous reports of odontogenic keratocyst (OKC) and orthokeratinized odontogenic cyst (OOC) with coverage of the old literature have tended to overlook the underlying theme of the first description. From a historical viewpoint, a French paper “kyste butyreux du sinus maxillaire simulant un cancer encephaloid” published in 1855 by Maisonneuve popularized the notion of so-called “buttery cyst”, which ultimately became known as jaw cyst with a keratinized lining. Soon after in 1856, Nelaton presented a case of OKC at the Anatomical Society of Paris, but his brief communication provided little information about its histopathology. It was Mikulicz who conducted, in 1876, a pioneering descriptive pathological study of OKC. In 1886, 10 years after Mikulicz’s German report, OOC was first described in detail by Jeannel of Toulouse. The mid to late decades of the nineteenth century saw notable European contributions on the topic.
- Published
- 2019
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