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Your search keyword '"Nae-Fang Miao"' showing total 2 results
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2 results on '"Nae-Fang Miao"'

1. Impact of Maspin Polymorphism rs2289520 G/C and Its Interaction with Gene to Gene, Alcohol Consumption Increase Susceptibility to Oral Cancer Occurrence

Author

Ying Erh Chou, Shun-Fa Yang, Hui Chuan Huang, Hsiu Ju Chang, Nae Fang Miao, Hsiu Ting Tsai, Chiao Wen Lin, and Po Yu Yang

Subjects
Male, lcsh:Medicine, Artificial Gene Amplification and Extension, Apoptosis, Polymerase Chain Reaction, 0302 clinical medicine, Medicine and Health Sciences, lcsh:Science, Areca, Multidisciplinary, Alcohol Consumption, biology, Cell Death, Cancer Risk Factors, Middle Aged, Oncology, Cell Processes, 030220 oncology & carcinogenesis, Physical Sciences, Female, Mouth Neoplasms, Alcohol consumption, Statistics (Mathematics), Research Article, Alcohol Drinking, Single-nucleotide polymorphism, Genetic Predisposition, Research and Analysis Methods, Polymorphism, Single Nucleotide, 03 medical and health sciences, Genetics, Confidence Intervals, Humans, Genetic Predisposition to Disease, Allele, Molecular Biology Techniques, Gene, Molecular Biology, Serpins, Alleles, Nutrition, Serine protease, Evolutionary Biology, Population Biology, lcsh:R, Maspin, Biology and Life Sciences, Heterozygote advantage, Epistasis, Genetic, 030206 dentistry, Cell Biology, biology.organism_classification, Diet, stomatognathic diseases, Genetic Loci, Case-Control Studies, Genetics of Disease, biology.protein, Cancer research, Genetic Polymorphism, lcsh:Q, Population Genetics, Mathematics
Abstract

BACKGROUND The purpose of this study was to identify gene polymorphisms of mammary serine protease inhibitor (Maspin) specific to patients with oral cancer susceptibility and clinicopathological status. METHODOLOGY/PRINCIPAL FINDINGS Three single-nucleotide polymorphisms (SNPs) of the Maspin gene from 741 patients with oral cancer and 601 non-cancer controls were analyzed by real-time PCR. The participants with G/G homozygotes or with G/C heterozygotes of Maspin rs2289520 polymorphism had a 2.07-fold (p = 0.01) and a 2.01-fold (p = 0.02) risk of developing oral cancer compared to those with C/C homozygotes. Moreover, gene-gene interaction increased the risk of oral cancer susceptibility among subjects expose to oral cancer related risk factors, including areca, alcohol, and tobacco consumption. CONCLUSION G allele of Maspin rs2289520 polymorphism may be a factor that increases the susceptibility to oral cancer. The interactions of gene to oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development.

Published
2016

2. Effects of Salivary Oxidative Markers on Edentulous Patients’ Satisfaction with Prosthetic Denture Treatments: A Pilot Study

Author

Yung Kai Huang, Chia Huang Chang, Che-Tong Lin, Nae-Fang Miao, Chang-Yu Lee, Sheng-Wei Feng, Pei Huan Lin, and Shin-Han Tsai

Subjects
Male, Saliva, Teeth, Physiology, lcsh:Medicine, Dentistry, Oral Health, Pilot Projects, Biochemistry, Antioxidants, 0302 clinical medicine, Surveys and Questionnaires, Medicine and Health Sciences, Medicine, Public and Occupational Health, 030212 general & internal medicine, lcsh:Science, Prosthetics, Multidisciplinary, Denture, Complete, biology, Physics, Dental Plaque Index, Enzymes, Body Fluids, Dismutases, Patient Satisfaction, Physical Sciences, Female, Anatomy, Mouth, Edentulous, Periodontal Index, Research Article, Biotechnology, Disabilities, Oral Medicine, Oxidative phosphorylation, Superoxide dismutase, 03 medical and health sciences, Patient satisfaction, Humans, Aged, Superoxide Dismutase, business.industry, lcsh:R, Biology and Life Sciences, Proteins, 030206 dentistry, Physical Properties, Jaw, Enzymology, biology.protein, lcsh:Q, Medical Devices and Equipment, business, Digestive System, Head, Biomarkers
Abstract

OBJECTIVES:The purpose of this study was to assess relationships among periodontal conditions, salivary antioxidant levels, and patients' satisfaction with their prostheses. METHODS:This study was conducted at the Division of Prosthodontics, Department of Dentistry, Taipei Medical University Hospital. The periodontal condition of patients was based on an assessment of the plaque index (PI) and gingival index (GI). The pH value, flow rate, and buffer capacity of the saliva were estimated. The salivary total antioxidant status (TAS) and superoxide dismutase (SOD) level were also determined. Patients' satisfaction with prosthetic treatments was evaluated using the Chinese version of the short-form Oral Health Impact Profile (OHIP-14C). A multivariate regression model was used to determine whether patients' satisfaction with prosthetic treatment was affected by their oral health status. RESULTS:In total, 35 edentulous patients were recruited. In the Spearman correlation analysis, salivary pH (r = -0.36, p = 0.03) and the buffer ability (r = -0.48, p

Published
2016
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