1. May hemocytometer parameters be a biomarker in distinguishing between adrenal adenomas and carcinomas and in prognosis of adrenocortical carcinomas?
- Author
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Soner Cander, Erdinc Erturk, Canan Ersoy, Ozlem Saraydaroglu, Buket Bicer, Pinar Sisman, Ozen Oz Gul, Bursa Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı., Bursa Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji ve Metabolizma Anabilim Dalı., Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı., Biçer, Buket, Gül, Özen, Cander, Soner, Ersoy, Canan, Saraydaroğlu, Özlem, Ertürk, Erdinç, AAI-1005-2021, AAJ-6536-2021, AAH-8861-2021, and AAH-9701-2021
- Subjects
Male ,030213 general clinical medicine ,0209 industrial biotechnology ,Adrenocortical carcinoma ,Platelet count ,Neutrophil count ,Plateletcrit ,Neutrophils ,Preoperative evaluation ,Adrenal cortex carcinoma ,lcsh:Medicine ,02 engineering and technology ,Gastroenterology ,020901 industrial engineering & automation ,0302 clinical medicine ,Cancer surgery ,Hemocytometer parameters ,Adrenal cortex neoplasms ,Lymphocytes ,Hematological parameters ,Original Scientific Papers ,Cancer ,Neutrophil ,Biochemical composition ,General Medicine ,Prognosis ,Management ,Cancer size ,Medicine, general & internal ,Neutrophil lymphocyte ratio ,Inflammation ,Glasgow ,Distant metastasis ,Biomarker (medicine) ,Female ,Lymphocyte ,Human ,Adenoma ,Adult ,medicine.medical_specialty ,Mean platelet volume ,Clinical article ,Article ,03 medical and health sciences ,Red blood cell distribution width ,Hemocytometer ,Internal medicine ,Neutrophil-to-lymphocyte ,medicine ,Carcinoma ,Postoperative period ,Adrenal adenoma ,Humans ,Neutrophil to lymphocyte ratio ,Adrenal cortex adenoma ,Cancer recurrence ,Platelet distribution width ,Adrenal cortex tumor ,Cancer prognosis ,business.industry ,lcsh:R ,Follow up ,medicine.disease ,Platelet lymphocyte ratio ,stomatognathic diseases ,Biological marker ,Human cell ,Cancer patient ,Lymphocyte count ,Data analysis software ,Disease marker ,General & internal medicine ,business ,Controlled study ,Biomarkers - Abstract
SUMMARY Recently, studies have reported that inflammatory response and elevated platelet counts are associated with several cancers. In the present study, we aimed to evaluate hemocytometer parameters in differentiating adrenal adenoma and carcinoma, and the prognostic utility of hemocytometer parameters in adrenocortical carcinoma (ACC). We included 30 patients with nonfunctional adrenal adenoma and 13 patients with ACC having undergone surgery between 2005 and 2017 and followed up postoperatively at our centre. The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), red blood cell distribution width (RDW), mean platelet volume (MPV) and plateletcrit (PCT) were evaluated preoperatively in all patients included in the study. There was a significant difference between the adrenal adenoma and ACC groups in terms of neutrophil and lymphocyte counts, NLR and PLR. There was no significant difference between the two groups in terms of platelet count and MPV, but PCT levels were significantly lower in ACC group. There was no statistically significant difference between recurrent and/or metastasis positive patients and negative ones according to NLR, PLR, RDW and MPV. There was a statistically significant difference in RDW levels and tumor diameter between the groups. Our study is the first to evaluate hemocytometer parameters in differentiating adrenal adenomas and carcinomas, and also in the prognosis of ACC. The present study suggested that the hemocytometer parameters may be a marker in the differential diagnosis of adrenal adenomas and carcinomas. However, our study also showed that these parameters had no prognostic value in ACC.
- Published
- 2020