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The change in the phase, from quiescence to surge, may perturb the glacier’s dynamical behavior. To understand these changes through geospatial technique, the fastest moving tidewater Monacobreen Glacier, Svalbard, was studied for the year 2016–2019. It was elucidated that the surge had initiated during 2017–2018 before it the glacier was in quiescence since 2001. Initially, the glacier radar zones, namely percolation refreeze, lower percolation, and clean ice, were identified using the multi-temporal SAR data. These zones were utilized to delineate the equilibrium line altitude, and it was found that it is continuously moving down during surging, unlike the quiescence phase. The accumulation area ratio was always more than 0.67 throughout the analysis. The seasonal change in glacier surface velocity for both the phases was estimated, adapting the most appropriate Offset Tracking approach using the SAR data. The mean velocity over the main trunk was found to vary from 0.5 to 4 m/day. Thereafter, Glen's flow law equation was used to estimate the ice-thickness and found that the glacier has an average thickness range of 216–326 m in quiescence and 136–244 m during the surging. The analysis depicted that the basal shear stresses are increasing with surging, and the viscosity is decreasing. It can be said that the transition of the glacier from quiescent to surging phase has entirely changed its dynamic behavior and characteristics. Further, in the absence of field observations, the geospatial technique may provide reasonable estimates of the glacier’s physical and dynamical parameters.

The study of hyperbolic waves involves various notions which help characterise how these structures evolve. One important facet is the notion of genuine nonlinearity, namely the ability for shocks and rarefactions to form instead of contact discontinuities. In the context of the Whitham modulation equations, this paper demonstrate that a loss of genuine nonlinearity leads to the appearance of a dispersive set of dynamics in the form of the modified Korteweg de-Vries equation governing the evolution of the waves instead. Its form is universal in the sense that its coefficients can be written entirely using linear properties of the underlying waves such as the conservation laws and linear dispersion relation. This insight is applied to two systems of physical interest, one an optical model and the other a stratified hydrodynamics experiment, to demonstrate how it can be used to provide insight into how waves in these systems evolve when genuine nonlinearity is lost.

Using in situ methods to characterize the state of a system during reactions is critical to understanding and improving solvothermal syntheses. This work demonstrates the use of in situ energy-dispersive X-ray diffraction (EDXRD) to investigate the local dynamics during solvothermal formation of Cu4O3 using a general-purpose full-sized laboratory oven. This allows for direct comparison of in situ data with laboratory-based reactions. Using in situ EDXRD, changes in the local amounts of Cu4O3, Cu2O and CuO within approximately 100 × 100 × 700 µm gauge volumes during solvothermal Cu4O3 formation were recorded. Fast conversion between Cu2O and CuO was observed in the solvothermal environment, whereas Cu4O3 was found to be chemically stable against disturbances once formed. The observed differences in local dynamics give further support to the differences in formation mechanisms between Cu4O3 and Cu2O/CuO proposed here.

We experimentally investigate the stochastic phase dynamics of planar Josephson junctions (JJs) and superconducting quantum interference devices (SQUIDs) defined in epitaxial InAs/Al heterostructures, and characterized by a large ratio of Josephson energy to charging energy. We observe a crossover from a regime of macroscopic quantum tunneling to one of phase diffusion as a function of temperature, where the transition temperature T∗ is gate-tunable. The switching probability distributions are shown to be consistent with a small shunt capacitance and moderate damping, resulting in a switching current which is a small fraction of the critical current. Phase locking between two JJs leads to a difference in switching current between that of a JJ measured in isolation and that of the same JJ measured in an asymmetric SQUID loop. In the case of the loop, T∗ is also tuned by a magnetic flux., Physical Review Letters, 130 (8), ISSN:0031-9007, ISSN:1079-7114

The phase of low-frequency, rhythmic cortical activity is essential for organizing brain processes because it provides a recurrent temporal frame for information coding. However, the low-frequency cortical phase exhibits great flexibility in response to external influences. Given that brain rhythms have been found to track respiratory inputs, we hypothesized that slow breathing, commonly associated with mental regulation, could reorganize the relationship between these two rhythmic systems through the adjustment of the cortical phase to such a slow train of inputs. Based on simultaneous magnetoencephalography and respiratory measurements, we report that while participants performed paced breathing, slow relative to normal breathing modulated cortical phase activity in the alpha range across widespread brain areas. Such modulation effects were specifically locked to the middle of the inspiration stage and exhibited a well-structured pattern. At the single-subject level, the phase angles underlying the effects became more likely to be diametrically opposed across breaths, indicating unique and consistent phase adjustment to slow inspiratory inputs. Neither cardiac fluctuations nor breathing-unrelated task effects could account for the findings. We suggest that slow-paced inspiration could organize the cortical phase in a regularized phase pattern, revealing a rhythmic but dynamic neural network integrated with different neurophysiological systems through volitional control. NEW & NOTEWORTHY Breathing is more complicated than a simple gas exchange, as it is integrated with numerous cognitive and emotional functions. Controlled slow breathing has often been used to regulate mental processes. This magnetoencephalography study demonstrates that slow-paced relative to normal-paced inspiration could organize the timing of alpha rhythmic activities across breathing cycles in a structured manner over widespread brain areas. Our results reveal how a volitionally controlled change in respiratory behavior could systematically modulate cortical activity.

We propose a novel method to reconstruct phase dynamics equations from responses in macroscopic variables to weak inputs. Developing linear and nonlinear response theories in coupled phase-oscillators, we derive formulae which connect the responses with the system parameters including the time delay in interactions. We examine our method by applying it to two phase models, one of which describes a mean-field network of the Hodgkin--Huxley type neurons with a nonzero time delay. The method does not require much invasiveness nor microscopic observations, and these advantages highlight its broad applicability in various fields., Comment: 12 pages, 5 figures

Nonlocally coupled oscillators with a phase lag self-organize into various patterns, such as global synchronization, the twisted state, and the chimera state. In this paper, we consider nonlocally coupled oscillators that move on a ring by randomly exchanging their positions with the neighbors and investigate the combined effects of phase lag and mobility on the collective phase dynamics. Spanning the whole range of phase lag and mobility, we show that mobility promotes synchronization for an attractive coupling, whereas it destroys coherence for a repulsive coupling. The transition behaviors are discussed in terms of the timescales of synchronization and diffusion of the oscillators. We also find a novel spatiotemporal pattern at the border between coherent and incoherent states.

The CALPHAD system of fundamental phase-level databases, now known as the Materials Genome, has enabled a mature technology of computational materials design and qualification that has already met the acceleration goals of the national Materials Genome Initiative. As first commercialized by QuesTek Innovations, the methodology combines efficient genomic-level parametric design of new material composition and process specifications with multidisciplinary simulation-based forecasting of manufacturing variation, integrating efficient uncertainty management. Recent projects demonstrated under the multi-institutional CHiMaD Design Center notably include novel alloys designed specifically for the new technology of additive manufacturing. With the proven success of the CALPHAD-based Materials Genome technology, current university research emphasizes new methodologies for affordable accelerated expansion of more accurate CALPHAD databases. Rapid adoption of these new capabilities by US apex corporations has compressed the materials design and development cycle to under 2 years, enabling a new "materials concurrency" integrated into a new level of concurrent engineering supporting an unprecedented level of manufacturing innovation.

Methanol is one of the most abundant interstellar Complex Organic Molecules (iCOMs) and represents a major building block for the synthesis of increasingly complex oxygen-containing molecules. The reaction between protonated methanol and its neutral counterpart, giving protonated dimethyl ether, (CH3)2OH+, along with the ejection of a water molecule, has been proposed as a key reaction in the synthesis of dimethyl ether in space. Here, gas phase vibrational spectra of the (CH3)2OH+ reaction product and the [C2H9O2]+ intermediate complex(es), formed under different pressure and temperature conditions, are presented. The widely tunable free electron laser for infrared experiments, FELIX, was employed to record these vibrational fingerprint spectra using different types of infrared action spectroscopy in the 600-1700 cm−1 frequency range, complemented with measurements using an OPO/OPA system to cover the O−H stretching region 3400−3700cm−1. The formation of protonated dimethyl ether as a product of the reaction is spectroscopically confirmed, providing the first gas-phase vibrational spectrum of this potentially relevant astrochemical ion.

Through its ability to image liquid-phase dynamics at nano/atomic-scale resolution, liquid-cell electron microscopy is essential for a wide range of applications, including wet-chemical synthesis, catalysis, and nanoparticle tracking, for which involved structural features are critical. However, statistical investigations by usual techniques remain challenging because of the difficulty in fabricating substantial liquid cells with appreciable efficiency. Here, we report a general approach for efficiently printing huge numbers of ready-to-use liquid cells (∼9000) within 30 s by electrospinning, with the unique feature of statistical liquid-phase studies requiring only one experimental time slot. Our solution efficiently resolves a complete transition picture of bubble evolution and also the induced nanoparticle motion. We statistically quantify the effect of the electron dose rate on the bubble variation and conclude that the bubble-driven nanoparticle motion is a ballistic-like behavior insignificant to morphological asymmetries. The versatile approach here is critical for statistical research, offering great opportunities in liquid-phase-associated dynamic studies.

Intrinsic optical signal (IOS) imaging promises a noninvasive method for objective assessment of retinal function. This study demonstrates concurrent optical coherence tomography (OCT) of amplitude-IOS and phase-IOS changes in human photoreceptors. A new procedure for differential-phase-mapping (DPM) is validated to enable depth-resolved phase-IOS imaging. Dynamic OCT revealed rapid amplitude-IOS and phase-IOS changes, which occur almost right away after the stimulus onset. These IOS changes were predominantly observed within the photoreceptor outer segment (OS), particularly two boundaries connecting to the inner segment and retinal pigment epithelium. The comparative analysis supports that both amplitude-IOS and phase-IOS attribute to transient OS morphological change associated with phototransduction activation in retinal photoreceptors. A simulation modeling is proposed to discuss the relationship between the photoreceptor OS length and phase-IOS changes.

The problem of directional coupling detection in ensembles of temporally evolving systems from observed time series is important in diverse fields. A small ensemble of three oscillators is a model of large ensembles which carry important features such as the distinction between direct and indirect influences and, therefore, allows the study of the methods for coupling detection in respect of their ability to distinguish between such influences and, hence, correctly identify directional couplings and provide their appropriate quantitative description. This work considers an ensemble of three exemplary oscillators as a test system to improve the coupling estimation method based on phase dynamics modeling and compare it to the spectral approach called Granger – Geweke spectrum. Possibilities of false conclusions about the structure of couplings are analyzed, sensitivity of both methods and interpretations of coupling characteristics are discussed.

Raw video files associated with the paper described as follows: The cellular cytoskeleton relies on diverse populations of motors, filaments, and binding proteins acting in concert to enable non-equilibrium processes ranging from mitosis to chemotaxis. The cytoskeleton’s versatile reconfigurability, programmed by interactions between its constituents, make it a foundational active matter platform. However, current active matter endeavors are limited largely to single force-generating components acting on a single substrate–far from the composite cytoskeleton in cells. Here, we engineer actin-microtubule composites, driven by kinesin and myosin motors and tuned by crosslinkers, to ballistically restructure and flow with speeds that span three orders of magnitude depending on the composite formulation and time relative to the onset of motor activity. Differential dynamic microscopy analyses reveal that kinesin and myosin compete to delay the onset of acceleration and suppress discrete restructuring events, while passive crosslinking of either actin or microtubules has an opposite effect. Our minimal advection-diffusion model and spatial correlation analyses correlate these dynamics to structure, with motor antagonism suppressing reconfiguration and de-mixing, while crosslinking enhances clustering. Despite the rich formulation space and emergent formulation-dependent structures, the non-equilibrium dynamics across all composites and timescales can be organized into three classes–slow isotropic reorientation, fast directional flow, and multimode restructuring. Moreover, our mathematical model demonstrates that diverse structural motifs can arise simply from the interplay between motor-driven advection and frictional drag. These general features of our platform facilitate applicability to other active matter systems, and shed light on diverse ways that cytoskeletal components can cooperate or compete to enable wide-ranging cellular processes.

Bipedal walking is the most prevalent form of human locomotion — versatile, robust, and efficient. However, it is a form of motion few other animals share, and plantigrade bipedalism is fairly unique to our species. Plantigrade feet play an important role in shaping the fundamental gait dynamics, and understanding their role unlocks a huge potential for biomechanical insights for locomotion research, gait rehabilitation, and humanoid robotics. Still, a comprehensive functional model of the foot, which ties the fundamental dynamics of walking to the interaction of foot and ground, does not yet exist due to the inherent mechanical complexity. In this paper, we present a set of assumptions in detail to simplify the development of a mathematical description of the foot’s motion during stance phase in human walking. These assumptions are validated using experimental data. We can show that the complex motion of the foot can be ultimately reduced to a simple rotation, which allows the formulation of a single degree of freedom equation of motion that ties proximal dynamics and constraints into a planar foot model of dynamic interactions.

The authors show that neural networks exhibiting noise-induced rhythms, also known as quasi-cycle oscillations, can synchronize through out-of-phase locking depending on the noise intensity and the size of the coupling delay

When a solute molecule is placed in solution, is it acceptable to presume that its electronic structure is essentially the same as that in the gas phase? In this paper, we address this question from a simulation perspective for the case of the sodium dimer cation (Na

The population and number dynamics of small mammals in the vicinity of the Torey lakes (Southeast Transbaikalia, Russia) were characterized between 2008 and 2017. The monitoring was carried out against the backdrop of the complete drying out of these largest lakes in the region. The stability of the fauna of small mammals was revealed over an 80-year period, although the structure of communities has changed significantly as a result of changes in moistening of the territory. Xerophilous species of mammals had an advantage in the period of studies in the dry climate phase. Correlation analysis showed a possible link between the population dynamics of some common species of small mammals with the precipitation amount of the current and previous years or with the precipitation amount of some spring (in one case, winter) months.

A transient metal Vanadium dioxide is known to have a coupled structural and electronic transition that can be accessed through light, thermal, or electrical excitation. Ultrafast optical studies of this insulator-to-metal transition indicate that it is mediated by the formation of a transient metallic phase that retains the structure of the original insulating phase. Sood et al. show that a similar sequence occurs when the material is electrically excited with a series of voltage pulses. Using ultrafast electron diffraction, the researchers monitored the structure of a vanadium dioxide sample after excitation and found evidence of a metastable metallic phase that appears during the transition. Science , abc0652, this issue p. 352

Although Mn-Ga alloys are discussed as novel permanent magnetic materials, there are several drawbacks, including the high price of Ga and the yet too small saturation magnetization to name a few. We used several guidelines to motivate the replacement of Ga by Sn to tackle these issues and explored the phase formation, structural and magnetic properties of a Mn 2.6 Ga 1− x Sn x alloy series. The structure of Sn-rich samples is dominated by the corresponding hexagonal and orthorhombic phases, while the structure of Ga-rich samples shows additional contributions from the tetragonal DO 22 structure. However, formation of the tetragonal phase happens only upon an appropriate annealing procedure. In contrast to the discussion in the literature, our experiments do not hint on the tetragonal DO 22 structure being metastable, but rather indicate the DO 22 structure being an equilibrium phase. In general, the experimentally found phase fractions impact on the magnetic properties and hard magnetic properties are downgraded very rapidly even if only a small amount of Ga is substituted by Sn. This indicates that the DO 22 phase found only in the Ga-rich samples is indeed the one which is most relevant for realization of high magnetic anisotropy.

The fragmentation of metals during megaplastic (severe) deformation is described in terms of a two-defect model. The process kinetics has been studied qualitatively. A general expression for the Lyapunov indices, which determine the stability of limiting (stationary) structures, is derived. Critical conditions for controlling parameters are found, and the diagrams that determine the stability of stationary states are constructed.

The study was carried out to evaluate the dynamics of monthly numbers of cases, deaths, tests and case fatality ratio worldwide during three phases of the COVID-19 pandemic. Material and methods: Twenty-three sets of databases, dated the 22nd of each month from January 2020 to November 2021, for 213 countries were collected from the Worldometer website. The number of cases, deaths, tests, case fatality ratio, infection fatality ratio, etc. were counted for various periods of time for each of the 213 countries, then the results related to different periods of time were compared. The analysis of main epidemiological parameters resulted in division of three phases of the global pandemic evolution. The first phase (23.01.20-22.07.20), the second phase (23.07.20-22.01.21) and the third phase (23.01.21-22.07.21) were different in terms of the number of tests performed, new cases and mortality due to COVID-19. By the end of second phase, the worldwide statistics indicated end of the pandemic, but the third phase was characterized by sudden rise in number of new cases and deaths. The most dramatic evolution of epidemic curve occurred in the countries where physicians had successfully confronted COVID-19 during the first two phases of the pandemic. Despite the decrease in the overall numbers deaths during the latest months analyzed, additional study is necessary to identify causes of new cases and deaths during the third phase of the pandemic. It can be suggested that preventive and therapeutic protocols should be changed from the 'standard' to 'personalized' types.

Noise can induce coherent oscillations in excitable systems without periodic orbits. Here, we establish a method to derive a hybrid system approximating the noise-induced coherent oscillations in excitable systems and further perform phase reduction of the hybrid system to derive an effective, dimensionality-reduced phase equation. We apply the reduced phase model to a periodically forced excitable system and two-coupled excitable systems, both undergoing noise-induced oscillations. The reduced phase model can quantitatively predict the entrainment of a single system to the periodic force and the mutual synchronization of two coupled systems, including the phase slipping behavior due to noise, as verified by Monte Carlo simulations. The derived phase model gives a simple and efficient description of noise-induced oscillations and can be applied to the analysis of more general cases.

The Josephson equations predict remarkable effects concerning the phase state of a superconducting junction with an oscillating current induced by a static voltage. Whether the paradigm can be twisted by yielding an oscillating voltage without making use of harmonic drives is a fundamentally relevant problem yet not fully settled. Here, we demonstrate that a dynamical regime with an oscillating phase evolution is a general hallmark of driven Josephson systems exhibiting sign competition in the Josephson couplings. We show that in frustrated Josephson systems an oscillating phase dynamics gets switched on by driving the changeover among different ground states, which can be induced by varying the parameters that set the phase state. Remarkably, the character of the transitions in the Josephson phase space allows different types of dynamics, with few or several harmonics. This result sets out a characteristic mark of any superconducting system with frustrated Josephson couplings and can be exploited to disentangle the complexity of the underlying phases., 11 pages, 7 figures

Aneurysmal subarachnoid haemorrhage (SAH) is a devastating subset of stroke. One of the major determinates of morbidity is the development of delayed cerebral ischemia (DCI). Disruption of the nitric oxide (NO) pathway and consequently the control of cerebral blood flow (CBF), known as cerebral autoregulation, is believed to play a role in its pathophysiology. Through the pharmacological manipulation of in vivo NO levels using an exogenous NO donor we sought to explore this relationship.Phase synchronisation index (PSI), an expression of the interdependence between CBF and arterial blood pressure (ABP) and thus cerebral autoregulation, was calculated before and during sodium nitrite administration in 10 high-grade SAH patients acutely postrupture. In patients that did not develop DCI, there was a significant increase in PSI around 0.1 Hz during the administration of sodium nitrite (33%; p-value 0.006). In patients that developed DCI, PSI did not change significantly.Synchronisation between ABP and CBF at 0.1 Hz has been proposed as a mechanism by which organ perfusion is maintained, during periods of physiological stress. These findings suggest that functional NO depletion plays a role in impaired cerebral autoregulation following SAH, but the development of DCI may have a distinct pathophysiological aetiology.

Objective:We assessed the delay times in the interaction between the autonomic regulatory loop of Heart Rate Variability (HRV) and autonomic regulatory loop of photoplethysmographic waveform variability (PPGV), showing low-frequency oscillations.Material and Methods:In eight healthy subjects aged 25–30 years (3 male, 5 female), we studied at rest (in a supine position) the simultaneously recorded two-hour signals of RR intervals (RRIs) chain and finger photoplethysmogram (PPG). To extract the low-frequency components of RRIs and PPG signal, associated with the low-frequency oscillations in HRV and PPGV with a frequency of about 0.1 Hz, we filtered RRIs and PPG with a bandpass 0.05-0.15 Hz filter. We used a method for the detection of coupling between oscillatory systems, based on the construction of predictive models of instantaneous phase dynamics, for the estimation of delay times in the interaction between the studied regulatory loops.Results:Averaged value of delay time in coupling from the regulatory loop of HRV to the loop of PPGV was 0.9±0.4 seconds (mean ± standard error of the means) and averaged value of delay time in coupling from PPGV to HRV was 4.1±1.1 seconds.Conclusion:Analysis of two-hour experimental time series of healthy subjects revealed the presence of delay times in the interaction between regulatory loops of HRV and PPGV. Estimated delay time in coupling regulatory loops from HRV to PPGV was about one second or even less, while the delay time in coupling from PPGV to HRV was about several seconds. The difference in delay times is explained by the fact that PPGV to HRV response is mediated through the autonomic nervous system (baroreflex), while the HRV to PPGV response is mediated mechanically via cardiac output.

Purpose The ecological environment of the Loess Plateau, China, is extremely fragile under the context of global warming. Over the past two decades, the vegetation of the Loess Plateau has undergone great changes. This paper aims to clarify the response mechanisms of vegetation to climate change, to provide support for the restoration and environmental treatment of vegetation on the Loess Plateau. Design/methodology/approach The Savitsky–Golay (S-G) filtering algorithm was used to reconstruct time series of moderate resolution imaging spectroradiometer (MODIS) 13A2 data. Combined with trend analysis and partial correlation analysis, the influence of climate change on the phenology and enhanced vegetation index (EVI) during the growing season was described. Findings The S-G filtering algorithm is suitable for EVI reconstruction of the Loess Plateau. The date of start of growing season was found to gradually later along the Southeast–Northwest direction, whereas the date of the end of the growing season showed the opposite pattern and the length of the growing season gradually shortened. Vegetation EVI values decreased gradually from Southeast to Northwest. Vegetation changed significantly and showed clear differentiation according to different topographic factors. Vegetation correlated positively with precipitation from April to July and with temperature from August to November. Originality/value This study provides technical support for ecological environmental assessment, restoration of regional vegetation coverage and environmental governance of the Loess Plateau over the past two decades. It also provides theoretical support for the prediction model of vegetation phenology changes based on remote sensing data.

Asymptotic AFM amplitude-phase dynamics is a powerful modeling tool for the development of AFM control systems and applications. We explain the model and demonstrate simple practical examples that can be easily programmed and analyzed using simulation tools such as Control and Simulation Loop (National Instruments) or Simulink (Mathworks). We first introduce asymptotic AFM models, then formulate their mathematical properties relevant to AFM, and provide examples of simulation for Hertz and Lennard-Jones tip-sample interaction forces. Material of this paper can be used to study and practice AFM dynamics in simulation, as well as for design of AFM model-based control modes and applications.

Under consideration is the system of partial differential equations describing the dynamics of a two-phase medium. Exact partially invariant solutions of rank 1 and defect 1 of this system are obtained with respect to some four-dimensional subalgebras. The phenomenon of collapse (an instantaneous source) in a two-phase medium is described.

The problem of interval estimation of the time delay of the coupling between oscillatory systems from observed time series is considered. It is shown that the known asymptotic estimates based on the empirical model in the form of a system of first-order phase oscillators and the maximum likelihood formalism can lead to false inferences of the value of the time delay in two typical situations: 1) nonlinear low-dimensional systems whose phases are well-determined but, as a result of significant amplitude fluctuations, the phase approximation is insufficient for describing the dynamics and 2) systems whose phases are defined not quite well because of too large amplitude fluctuations. A method for empirical diagnostics of problematic situations and its modification (coarse estimation) providing a low probability of false inferences in these situation are proposed. The efficiency of the diagnostic criterion and coarse estimation suggested is demonstrated on reference systems with different dynamic properties (linear stochastic oscillators, van der Pol oscillators, and Ressler and Lorenz chaotic systems).

We investigate nonlinear phase dynamics of an ideal kink mode, induced by E × B flow. Here the phase is the cross phase (θ c) between perturbed stream function of velocity ( ϕ ˜ ) and magnetic field ( ψ ˜ ), i.e. θ c = θ ϕ − θ ψ . A dimensionless parameter, analogous to the Richardson number, R i = 16 γ kink 2 / ω ˆ E 2 (γ kink: the normalized growth rate of the pure kink mode; ω ˆ E : normalized E × B shearing rate) is defined to measure the competition between phase pinning by the current density and phase detuning by the flow shear. When R i > 1, θ c is locked to a fixed value, corresponding to the conventional eigenmode solution. When R i ≤ 1, θ c enters a phase slipping or oscillating state, corresponding to a nonmodal solution. The nonlinear phase dynamics method provides a more intuitive explanation of the complex dynamical behavior of the kink mode in the presence of E × B shear flow.

A promising approach for efficiently solving NP-hard optimization problems is based on mapping the problems onto Ising machines. Oscillator-based Ising machines can be implemented by utilizing sub-harmonic injection locking, which enables binary phase shifts between the oscillators and leads to an improved reliability of Ising machines. Based on a modified Kuramoto model with sub-harmonic injection locking, we synthesize an ideal electrical circuit displaying the phase dynamics of an Ising machine. The ideal circuit can be utilized to specifically take non-ideal effects into account, serving as a starting point for designing Ising machines with increased performance when considering existing electrical components. We furthermore derive a corresponding wave digital model, which is utilized for emulating the synthesized electrical circuit. The emulation results show that the synthesized circuit indeed models the phase dynamics of an Ising machine capable of solving Max-Cut problems with an accuracy of 88% for a 5-node problem and weights between 0 and 31.

The cytoskeleton of biological cells relies on a diverse population of motors, filaments, and binding proteins acting in concert to enable non-equilibrium processes ranging from mitosis to chemotaxis. The cytoskeleton’s versatile reconfigurability, programmed by interactions between its constituents, make it a foundational active matter platform. However, current active matter endeavors are limited largely to single force-generating components acting on a single substrate – far from the composite cytoskeleton in live cells. Here, we engineer actin-microtubule composites, driven by kinesin and myosin motors and tuned by crosslinkers, that restructure into diverse morphologies from interpenetrating filamentous networks to de-mixed amorphous clusters. Our Fourier analyses reveal that kinesin and myosin compete to delay kinesin-driven restructuring and suppress de-mixing and flow, while crosslinking accelerates reorganization and promotes actin-microtubule correlations. The phase space of non-equilibrium dynamics falls into three broad classes– slow reconfiguration, fast advective flow, and multi-mode ballistic dynamics – with structure-dynamics relations described by the relative contributions of elastic and dissipative responses to motor-generated forces.

The third-order response lies at the heart of simulating and interpreting nonlinear spectroscopies ranging from two-dimensional infrared (2D-IR) to 2D electronic (2D-ES), and 2D sum frequency generation (2D-SFG). The extra time and frequency dimensions in these spectroscopic techniques provide access to rich information on the electronic and vibrational states present, the coupling between them, and the resulting rates at which they exchange energy that are obscured in linear spectroscopy, particularly for condensed phase systems that usually contain many overlapping features. While the exact quantum expression for the third-order response is well established, it is incompatible with the methods that are practical for calculating the atomistic dynamics of large condensed phase systems. These methods, which include both classical mechanics and quantum dynamics methods that retain quantum statistical properties while obeying the symmetries of classical dynamics, such as LSC-IVR, centroid molecular dynamics, and Ring Polymer Molecular Dynamics (RPMD), naturally provide short-time approximations to the multi-time symmetrized Kubo transformed correlation function. Here, we show how the third-order response can be formulated in terms of equilibrium symmetrized Kubo transformed correlation functions. We demonstrate the utility and accuracy of our approach by showing how it can be used to obtain the third-order response of a series of model systems using both classical dynamics and RPMD. In particular, we show that this approach captures features such as anharmonically induced vertical splittings and peak shifts while providing a physically transparent framework for understanding multidimensional spectroscopies.

The study was carried out to evaluate the dynamics of monthly numbers of cases, deaths, tests and case fatality ratio worldwide during three phases of the COVID-19 pandemic. Material and methods: Twenty-three sets of databases, dated the 22nd of each month from January 2020 to November 2021, for 213 countries were collected from the Worldometer website. The number of cases, deaths, tests, case fatality ratio, infection fatality ratio, etc. were counted for various periods of time for each of the 213 countries, then the results related to different periods of time were compared. The analysis of main epidemiological parameters resulted in division of three phases of the global pandemic evolution. The first phase (23.01.20-22.07.20), the second phase (23.07.20-22.01.21) and the third phase (23.01.21-22.07.21) were different in terms of the number of tests performed, new cases and mortality due to COVID-19. By the end of second phase, the worldwide statistics indicated imminent end of the pandemic, but the third phase was characterized by sudden rise in the number of new cases and deaths that could not be explained rationally. The most dramatic evolution of epidemic curve occurred in the countries where physicians had successfully confronted COVID-19 during the first two phases of the pandemic. Despite the decrease in the overall numbers deaths during the latest months analyzed, additional study is necessary to identify the cause of increasing in the number of new cases and deaths during the third phase of the pandemic. Presumably, there are several causes of negative evolution of the current pandemic, including over-reliance on polymerase chain reaction tests, application of non-specialized premises for quarantine and treatment, non-professional management, following therapeutic protocols applied in countries with high number of deaths, ignoring preventive treatment, and decreasing in mass and individual immunity. It can be suggested that the use of drugs modulating T-cell immunity is necessary, and preventive and therapeutic protocols should be changed from the 'standard' to 'personalized' types.

Significance The three spectral types of cone photoreceptors underlie color perception and are largely responsible for inherited and acquired color vision anomalies. In vivo mapping of the trichromatic cone mosaic by imaging provides the most direct and quantitative means to assess the role of photoreceptors in color vision, but remains challenging because cone reflections only weakly differentiate cone types. Here, we show a noninvasive light microscopy modality that reveals the cell’s spectral type, using the optical phase change that arises within the cell when stimulated with light. Our procedure is orders of magnitude faster and more accurate than prior approaches and makes in vivo cone classification promising for a much wider range of color vision applications., Human color vision is achieved by mixing neural signals from cone photoreceptors sensitive to different wavelengths of light. The spatial arrangement and proportion of these spectral types in the retina set fundamental limits on color perception, and abnormal or missing types are responsible for color vision loss. Imaging provides the most direct and quantitative means to study these photoreceptor properties at the cellular scale in the living human retina, but remains challenging. Current methods rely on retinal densitometry to distinguish cone types, a prohibitively slow process. Here, we show that photostimulation-induced optical phase changes occur in cone cells and carry substantial information about spectral type, enabling cones to be differentiated with unprecedented accuracy and efficiency. Moreover, these phase dynamics arise from physiological activity occurring on dramatically different timescales (from milliseconds to seconds) inside the cone outer segment, thus exposing the phototransduction cascade and subsequent downstream effects. We captured these dynamics in cones of subjects with normal color vision and a deuteranope, and at different macular locations by: (i) marrying adaptive optics to phase-sensitive optical coherence tomography to avoid optical blurring of the eye, (ii) acquiring images at high speed that samples phase dynamics at up to 3 KHz, and (iii) localizing phase changes to the cone outer segment, where photoactivation occurs. Our method should have broad appeal for color vision applications in which the underlying neural processing of photoreceptors is sought and for investigations of retinal diseases that affect cone function.

Chemical dynamics simulations are performed to study the dissociation of excited benzene-hexafluorobenzene (Bz-HFB) complex in N2 bath and the results are compared with the gas phase dynamics. Two N2 bath densities 20 and 750 kg/m3 are considered. Bz-HFB is excited with respect to the temperatures of 1000, 1500, and 2000 K at each bath density. The nature of the Bz-HFB* dissociation dynamics at the bath density of 20 kg/m3 is quite similar to gas phase one, but the same is drastically different at high bath density where energy transfer pathway dominates over dissociation and negligible direct dissociation of Bz-HFB* is reported.

First order phase reduced model is a good approximation of the dynamics of forced nonlinear oscillators near its limit cycle. The phase evolution is determined by the unforced frequency, the forcing term, and the phase response curve (PRC). Such models arise in biological oscillations such as in circadian rhythm, neural signaling, heart beat, etc. This technical note focuses on the phase regulation of the circadian rhythm using light intensity as the input. Though the model is simple, the circle topology of the state space needs to be carefully addressed. The most common entrainment method is to use a periodic input, such as in our daily light-dark cycle. We obtain the complete stable entrainment condition based on the entraiment input and the PRC. Motivated by the jet-lag problem, we also consider the minimum time entrainment control to achieve a specified phase shift. Application of the Pontryagin Minimum Principle leads to an efficient solution strategy for the optimal control, without solving the two-point boundary value problem. The optimal control may be further represented as a feedback control law based on the current and desired phases. Our analysis allows the answer to questions such as: When traveling from New York to Paris, is it faster to use light to shift the phase forward by 6 hours or delay the phase by 18 hours? The answer is somewhat counter-intuitive—delaying by 18 hours requires less time. The general answer depends on the light intensity level and the shape of the PRC. PRCs for human and Drosophila from the literature are used to illustrate the results.

Cycle slips strongly impact the performance of phase tracking algorithm leading, in the worst case, to a permanent loss of lock of the signal. In this paper, we propose a new nonlinear phase estimator to obtain more robust tracks. The latter stems from a Variational Bayes (VB) approximation used within the optimal Bayesian filtering formulation in case of high-order phase dynamics. A comparison with a more conventional technique, namely a Kalman filter based PLL (Phase Lock Loop), is performed in terms of mean square error of the phase estimate and mean time to first slip. Results show that the proposed method outperforms the conventional linear filter with respect to both metrics, especially at low signal-to-noise ratio.

Background Growth differentiation factor 15 (GDF-15) in ST-elevation myocardial infarction (STEMI) is prognostic in first-generation radioimmunoassays. We examined GDF-15 temporal dynamics in STEMI and its predictive value using a first fully automated GDF-15 electrochemiluminescence assay. Methods In this prospective study, circulating GDF-15 concentration was measured at admission (0 h), 12 h and 24 h in 1026 consecutive STEMI patients treated between February 2011 and May 2016 with primary percutaneous coronary intervention. GDF-15 dynamics (0 h, 12 h, 24 h) and predictive value (30 days and 3 years) were examined. Results Median GDF-15 concentration was 1443 pg/mL at 0 h, 1731 pg/mL at 12 h and 1510 pg/mL at 24 h (p Conclusions GDF-15 peaked at 12 h and remained elevated at 24 h in STEMI. GDF-15 measurement during the first 24 h in STEMI is valuable for predicting especially short- but also long-term outcomes, and may be a useful addition to risk stratification.

In this work, a Lattice-Boltzmann-Method (LBM) model for simulating hysteresis in a proton exchange membrane (PEMFC) electrode is presented. One of the main challenges hindering study of the cathode catalyst layer (CCL) in PEMFCs is the lack of understanding of two-phase transport and how it affects electrochemical performance. Researchers have typically used high level approximations that oversimplify the microstructure of the CCL—these are known as macrohomogenous models. However, as the field has progressed, the flaws in these idealizations are being revealed, especially in areas of improving our understanding of flooding as well as catalyst layer hysteresis. Previously, the microstructure details needed to build an accurate mesoscale model have eluded researchers; however, with advances in tomography and focused-ion-beam scanning-electron-microscopy (FIB-SEM), creating these representations has become possible. Using LBM with these representations, the difficult problem of catalyst layer capillary hysteresis can be examined. In two-phase capillary hysteresis, both the equilibrium saturation position as well as absolute value depends on the wetting history. Based on the models, it is ascertained that at lower capillary numbers, the liquid begins to undergo capillary fingering – only above a capillary pressure of 5 MPa, a regime change into stable displacement is observed. As capillary fingering does not lead to uniform removal of liquid, the prediction is that because high capillary pressures are needed to change to the regime of stable displacement, wicking will not be an effective means of water removal. Figure 1

In this work, the scaling behavior of the sleep process is evaluated by using detrended fluctuation analysis based on wavelets. The analysis is carried out from arrivals of short and recurrent cortical events called A-phases, which in turn build up the Cyclic Alternating Pattern phenomenon, and are classified in three types: A1, A2 and A3. In this study, 61 sleep recordings corresponding to healthy, nocturnal frontal lobe epilepsy patients and sleep-state misperception subjects, were analyzed. From the A-phase annotations, the onsets were extracted and a binary sequence with one second resolution was generated. An item in the sequence has a value of one if an A-phase onset occurs in the corresponding window, and a value of zero otherwise. In addition, we consider other different temporal resolutions from 2[Formula: see text]s to 256[Formula: see text]s. Furthermore, the same analysis was carried out for sequences obtained from the different types of A-phases and their combinations. The results of the numerical analysis showed a relationship between the time resolutions and the scaling exponents; specifically, for higher time resolutions a white noise behavior is observed, whereas for lower time resolutions a behavior towards to [Formula: see text]-noise is exhibited. Statistical differences among groups were observed by applying various wavelet functions from the Daubechies family and choosing the appropriate sequence of A-phase onsets. This scaling analysis allows the characterization of the free-scale dynamic of the sleep process that is specific for each sleep condition. The scaling exponent could be useful as a diagnosis parameter in clinics when sleep macrostructure does not offer enough information.