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This work was supported in part by the Ministry of Higher Education, Malaysia, under Grant FRGS FP094/2007c. We would like to thank the reviewers of this paper for their helpful comments and suggestions which improved our paper. In addition, we would like to thank ARM and Silterra Malaysia for providing the standard cell libraries under the university program and Trans-Dist Engineering for its technical support. The sub-pixel motion estimation (SME), together with the interpolation of reference frames, is a computationally extensive part of the H.264 encoder that increases the memory requirement 16-times for each reference frame. Due to the huge computational complexity and memory requirement of the H.264 SME, its hardware architecture design is an important issue especially in high resolution or low power applications. To solve the above difficulties, we propose several optimization techniques in both algorithm and architecture levels. In the algorithm level, we propose a parabolic based algorithm for SME with quarter-pixel accuracy which reduces the computational budget by 94.35% and the memory access requirement by 98.5% in comparison to the standard interpolate and search method. In addition, a fast version of the proposed algorithm is presented that reduces the computational budget 46.28% further while maintaining the video quality. In the architecture level, we propose a novel bit-serial architecture for our algorithm. Due to advantages of the bit-serial architecture, it has a low gate count, high speed operation frequency, low density interconnection, and a reduced number of I/O pins. Also, several optimization techniques including the sum of absolute differences truncation, source sharing exploiting and power saving techniques are applied to the proposed architecture which reduce power consumption and area. Our design can save between 57.71-90.01% of area cost and improves the macroblock (MB) processing speed between 1.7-8.44 times when compared to previous designs. Implementation results show that our design can support real time HD1080 format with 20.3 k gate counts at the operation frequency of 144.9 MHz. This work was supported in part by the Ministry of Higher Education, Malaysia, under Grant FRGS FP094/2007c. We would like to thank the reviewers of this paper for their helpful comments and suggestions which improved our paper. In addition, we would like to thank ARM and Silterra Malaysia for providing the standard cell libraries under the university program and Trans-Dist Engineering for its technical support Ministry of Education, Malaysia Publisher's version Q4 WOS:000285107500003

To have a better understanding of the mechanisms of disease development, knowledge of mutations and the genes on which the mutations occur is of crucial importance. Information on disease-related mutations can be accessed through public databases or biomedical literature sources. However, information retrieval from such resources can be problematic because of two reasons: manually created databases are usually incomplete and not up to date, and reading through a vast amount of publicly available biomedical documents is very time-consuming. In this paper, we describe an automated system, MuGeX (Mutation Gene eXtractor), that automatically extracts mutation–gene pairs from Medline abstracts for a disease query. Our system is tested on a corpus that consists of 231 Medline abstracts. While recall for mutation detection alone is 85.9%, precision is 95.9%. For extraction of mutation–gene pairs, we focus on Alzheimer's disease. The recall for mutation–gene pair identification is estimated at 91.3%, and precision is estimated at 88.9%. With automatic extraction techniques, MuGeX overcomes the problems of information retrieval from public resources and reduces the time required to access relevant information, while preserving the accuracy of retrieved information.