1. Electrochemical Aptasensors Based on Hybrid Metal-Organic Frameworks
- Author
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Svetlana Belyakova, Tibor Hianik, Anna Porfireva, and Gennady Evtugyn
- Subjects
Materials science ,Aptamer ,Variable size ,MOF MATERIALS ,3-D networks ,Nanotechnology ,Review ,02 engineering and technology ,Electrochemistry ,lcsh:Chemical technology ,01 natural sciences ,Biochemistry ,Analytical Chemistry ,FUTURE TRENDS ,METAL-ORGANIC FRAMEWORKS ,BIORECEPTORS ,HIGH POROSITY ,Electrochemical biosensor ,lcsh:TP1-1185 ,aptasensor ,Electrical and Electronic Engineering ,Instrumentation ,metal-organic frameworks ,VARIABLE SIZES ,reticular materials ,SIGNAL GENERATION ,010401 analytical chemistry ,ORGANOMETALLICS ,RETICULAR MATERIALS ,021001 nanoscience & nanotechnology ,3-D NETWORKS ,Atomic and Molecular Physics, and Optics ,0104 chemical sciences ,APTASENSOR ,electrochemical biosensor ,MORPHOLOGY ,Metal-organic framework ,ELECTROCHEMICAL BIOSENSOR ,0210 nano-technology ,METALORGANIC FRAMEWORKS (MOFS) - Abstract
Metal-organic frameworks (MOFs) offer a unique variety of properties and morphology of the structure that make it possible to extend the performance of existing and design new electrochemical biosensors. High porosity, variable size and morphology, compatibility with common components of electrochemical sensors, and easy combination with bioreceptors make MOFs very attractive for application in the assembly of electrochemical aptasensors. In this review, the progress in the synthesis and application of the MOFs in electrochemical aptasensors are considered with an emphasis on the role of the MOF materials in aptamer immobilization and signal generation. The literature information of the use of MOFs in electrochemical aptasensors is classified in accordance with the nature and role of MOFs and a signal mode. In conclusion, future trends in the application of MOFs in electrochemical aptasensors are briefly discussed. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. A.P. acknowledges support of the Russian Science Foundation (grant No 17-73-20024) in part related to the analysis of the reaction conditions and operation of the MOF aptasensors. T.H. acknowledges funding from the Science Grant Agency VEGA, project No.: 1/0419/20.
- Published
- 2020