1. Water-Soluble Fullerenol with Hydroxyl Group Dependence for Efficient Two-Photon Excited Photodynamic Inactivation of Infectious Microbes
- Author
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Yen Sung Lin, Yu Ting Shao, Ping Ching Wu, Chia Yuan Chang, Jui Chang Liu, Jiu Yao Wang, Wen Shuo Kuo, and Edmund Cheung So
- Subjects
Materials science ,medicine.medical_treatment ,Nanochemistry ,Quantum yield ,Photodynamic therapy ,Water-soluble fullerenol ,02 engineering and technology ,010402 general chemistry ,Photochemistry ,medicine.disease_cause ,01 natural sciences ,chemistry.chemical_compound ,lcsh:TA401-492 ,medicine ,General Materials Science ,Photosensitizer ,Singlet oxygen quantum yield ,Escherichia coli ,chemistry.chemical_classification ,Reactive oxygen species ,Two-photon excitation ,Nano Express ,Singlet oxygen ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Composition of exposed hydroxyl groups ,0104 chemical sciences ,chemistry ,Excited state ,lcsh:Materials of engineering and construction. Mechanics of materials ,0210 nano-technology - Abstract
We successfully prepared water-soluble fullerenol [C60(OH)46] that exhibited a high singlet oxygen quantum yield and efficiently generated reactive oxygen species. Additionally, the water-soluble C60(OH)46 with a higher composition of exposed hydroxyl groups had superior two-photon stability and characteristics compared with that with a lower composition of such groups. Therefore, the prepared fullerenol can be an effective two-photon photosensitizer. The water-soluble C60(OH)46 had favorable two-photon properties. During two-photon photodynamic therapy, the water-soluble C60(OH)46 had substantial antimicrobial activity against Escherichia coli at an ultralow-energy level of 211.2 nJ pixel−1 with 800 scans and a photoexcited wavelength of 760 nm.
- Published
- 2020
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