1. Chitosan oligosaccharide affects antioxidant defense capacity and placental amino acids transport of sows
- Author
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Chunyan Xie, Xin Wu, Siming Li, Qinhua Wang, Yulong Yin, Zhiyong Fan, and Cimin Long
- Subjects
0301 basic medicine ,Antioxidant ,Swine ,medicine.medical_treatment ,Placenta ,Biological Transport, Active ,Biology ,Pregnancy Proteins ,Antioxidants ,Andrology ,03 medical and health sciences ,Pregnancy ,Antioxidant defense ,medicine ,Animals ,Amino Acids ,PI3K/AKT/mTOR pathway ,chemistry.chemical_classification ,Fetus ,Chitosan ,General Veterinary ,Amino acids transport ,0402 animal and dairy science ,Chitosan oligosaccharides ,04 agricultural and veterinary sciences ,General Medicine ,medicine.disease ,040201 dairy & animal science ,Animal Feed ,veterinary(all) ,Amino acid ,030104 developmental biology ,medicine.anatomical_structure ,Enzyme ,Biochemistry ,chemistry ,Dietary Supplements ,Sow ,Gestation ,Female ,Research Article - Abstract
Background Chitosan oligosaccharide (COS) is widely consumed as a functional food due to its multiple health effects, but few studies about COS supplement on placental antioxidant and nutrition transport capacity were reported. Taken pregnant sow as a model, we aimed to investigate the effects of dietary COS supplementation during late gestation on placental amino acids transport and antioxidant defense capacity of sows. From day (d) 85 of gestation to parturition, sixteen pregnant sows were divided into a control group (basal diet without COS supplementation) and a COS group (30 mg COS/kg basal diet). Plasma sample of sow was collected on d 110 of gestation, and placenta tissue was obtained during parturition. Then plasma antioxidant enzyme’s activities, the relative level of oxidant stress related genes, amino acids transport related genes and mTOR pathway molecules in placenta were determined. Results Results showed that maternal dietary supplementation with COS increased (P
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