957,945 results
Search Results
2. Randomized Controlled Trial of Paper-Based at a Hospital versus Continual Electronic Patient-Reported Outcomes at Home for Metastatic Cancer Patients: Does Electronic Measurement at Home Detect Patients' Health Status in Greater Detail?
- Author
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Naruto Taira, Kojiro Shimozuma, Takashi Fukuda, Takuya Kawahara, Takeru Shiroiwa, Shinichi Noto, Yasuhiro Hagiwara, Tetsuya Iwamoto, and Keiko Konomura
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medicine.medical_specialty ,business.industry ,Health Policy ,Health Status ,Cancer ,Paper based ,medicine.disease ,Outcome (game theory) ,Eortc qlq c 30 ,Hospitals ,law.invention ,Randomized controlled trial ,Quality of life ,law ,Neoplasms ,Surveys and Questionnaires ,Physical therapy ,Quality of Life ,Medicine ,Humans ,Patient-reported outcome ,Patient Reported Outcome Measures ,Electronics ,business - Abstract
Purpose This study aimed to determine whether continual electronic patient-reported outcome (ePRO) measurements at home can capture the fluctuations in health-related quality of life (HRQOL) scores between visits. Methods We performed a randomized controlled trial to compare the scores obtained by standard practice (paper-based measurements in the hospital) to scores by continuous measurement of ePRO at home. Metastatic cancer patients were randomly assigned to either the paper-based ( n = 50) or the ePRO group ( n = 52). EQ-5D-5L and EORTC QLQ C-30 scores were obtained on 3 different chemotherapy days in the paper-based group. Meanwhile, scores were obtained on the chemotherapy day and on days 3, 7, 10, and 14 in the ePRO group during 2 cycles. The first hypothesis of our study was that both scores at the same time points would be equivalent despite different measurement frequency, place, or mode of measurement. The second hypothesis was that PRO score–adjusted time would be different between the groups. For equivalence, the endpoint was the mean EQ-5D-5L index value on the chemotherapy day before the outpatient treatment. Only if equivalence was shown, quality-adjusted life-days (QALDs) were considered using all the data. Results The adjusted mean difference in the EQ-5D-5L index was determined to be −0.013 (95% confidence interval [CI]: −0.049 to 0.022); the 95% CI did not exceed the equivalence margin. Similarly, the mean difference in global health status (2.28 [95% CI: −2.55 to 7.11]) also showed equivalence. However, the QALD by EQ-5D-5L was significantly lower in the ePRO group by 1.36 per 30 d (95% CI: −2.22 to −0.51; P = 0.0021). Conclusions Continual measurements of the HRQOL at home by ePRO may yield more detailed profiles of the HRQOL.
- Published
- 2022
3. Fire resistant bagasse paper as packaging material using 1,3-di-p-toluidine-2,2,2,4,4,4-hexachlorocyclodiphosph(V)azane with hydroxyethyl cellulose
- Author
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Salah A.A. Mohamed, A.A. Younis, and Mohamed El-Sakhawy
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Thermogravimetric analysis ,Materials science ,Mechanical properties ,Oxygen index ,Catalysis ,law.invention ,Limiting oxygen index ,Fire resistant ,chemistry.chemical_compound ,Geochemistry and Petrology ,law ,UL/94 ,Ultimate tensile strength ,Petroleum refining. Petroleum products ,Cellulose ,Renewable Energy, Sustainability and the Environment ,Process Chemistry and Technology ,Organic Chemistry ,Azane ,Ignition system ,Fuel Technology ,chemistry ,Chemical engineering ,Bagasse paper ,1,3-Di-p-toluidine-2,2,2,4,4,4-hexachlorocyclodiphosph(V)azane ,Bagasse ,TP690-692.5 ,Hydroxyethyl cellulose - Abstract
This manuscript aimed to enhance the mechanical, thermal, and ignition properties of bagasse paper when coated with different coatings synthesized from hydroxyethyl cellulose, 1,3-di-p-toluidine-2,2,2,4,4,4-hexachlorocyclodiphosph(V)azane, Talc powder, NaHCO3, cellulose nanocrystal. The effect of these coatings on the mechanical properties was studied by measuring elongation, tensile strength, and burst strength. The stages of degradation and ash residue of the measuring specimens were determined using thermal gravimetric analysis (TGA), behind that, the ignition properties as the flame chamber (UL/94), and limiting oxygen index (LOI) was measured according to standards. These tests proved that 1,3-di-p-toluidine-2,2,2,4,4,4-hexachlorocyclodiphosph(V)azane has a direct effect on improving the mechanical characteristics and enhancing the ignition properties of the coated specimens compared to uncoated. In this study the physical, mechanical, thermal, and ignition properties of the bagasse paper sheets were enhanced by easy and low-cost method via synthesis of new coatings based on commercially available chemicals in a reasonable cost.
- Published
- 2021
4. In-situ joule heating-triggered nanopores generation in laser-induced graphene papers for capacitive enhancement
- Author
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Fu Liu, Guantao Wang, Meihong He, Yanan Wang, Yuxiang Zhu, and Sida Luo
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Fabrication ,Materials science ,business.industry ,Graphene ,Capacitive sensing ,General Chemistry ,Capacitance ,law.invention ,Nanopore ,Amorphous carbon ,law ,Optoelectronics ,General Materials Science ,business ,Joule heating ,Graphene oxide paper - Abstract
Laser-induced graphene (LIG) technology featuring low-cost, high-efficiency and scalability has presented great advantages in micro-supercapacitors (MSCs) fabrication. However, the limited capacitance of LIG based MSCs is still hindering their further development. Herein, we introduce joule heating as a critical in-situ treatment merged with the assembly of laser-induced graphene paper based MSCs (LIGP-MSCs) toward capacitive enhancement. By increasing heating-treatment temperature from ∼20 to 500 °C, the number of nanopores in LIGP continuously increases, attributed to the gradual decomposition of amorphous carbon components. The resulting joule-heated LIGP (J-LIGP) with improved specific surface area (160.97–533.49 m2/g) and pore volume (0.179–0.553 cm3/g) as well as superhydrophilic surface is highly suitable to be employed as J-LIGP-MSCs microelectrodes. By investigating process dependent performance, the J-LIGP-MSCs heated at 500 °C for 60 min delivers a significantly improved specific areal capacitance (CA) of 13.71 mF/cm2 at 10 mV/s, which is approximately six-fold higher than that of unheated LIGP-MSCs. By further exploring and optimizing the process efficiency, J-LIGP-MSCs with a CA of 12.61 mF/cm2 has been achieved by 550 °C heating for only 5 min. Along with superior mechanical flexibility, cyclability and structural modularity, the proposed in-situ joule heating treatment is finally proved to be a universal approach for consistently enhancing the CA of LIG based MSCs processed under various chemical modifications.
- Published
- 2022
5. Effect of Partial Oil Change on Furfural Partitioning in Oil-Paper-Pressboard Insulation System
- Author
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Yiyi Zhang, Xianhao Fan, Jiefeng Liu, Heng Zhang, and Chuhan Geng
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Work (thermodynamics) ,Pressboard ,Moisture ,Pulp and paper industry ,Furfural ,Accelerated aging ,law.invention ,chemistry.chemical_compound ,chemistry ,law ,Insulation system ,Environmental science ,Electrical and Electronic Engineering ,Transformer ,Kraft paper - Abstract
The total/partial oil change treatment can affect the furfural partitioning in oil-paper-pressboard insulation, resulting in poor accuracy of furfural analysis. Moreover, due to the high cost of total oil change, partial oil change is more practical during transformer operation. This paper investigates the furfural partitioning in the oil-paper-pressboard insulation under partial oil change conditions. First, the initial furfural partitioning equation with non-oil change is proposed based on the obtained furfural content in oil, paper, and pressboard. Then, the modified furfural partitioning model under partial oil change condition is established by introducing a correction factor. Moreover, a preliminary correction scheme for the furfural partitioning model considering the influence of moisture and acid is provided. Finally, furfural content in oil-Kraft paper and oil-thermally upgraded Kraft (TUK) paper insulation are discussed, and results indicate that the proposed modified furfural partitioning model is not suitable for the oil-TUK paper insulation. This work can provide theoretical support for furfural analysis of oil-immersed transformers.
- Published
- 2021
6. High strength, flexible, and conductive graphene/polypropylene fiber paper fabricated via papermaking process
- Author
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Quanbo Huang, Wenjiao Ge, Shan Cao, Yang Yang, and Xiaohui Wang
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Polypropylene ,Materials science ,Polymers and Plastics ,Graphene ,Materials Science (miscellaneous) ,Papermaking ,Composite number ,Conductivity ,law.invention ,chemistry.chemical_compound ,Synthetic fiber ,chemistry ,law ,Materials Chemistry ,Ceramics and Composites ,Fiber ,Composite material ,Graphene oxide paper - Abstract
Graphene paper with good mechanical strength, flexibility, and high conductivity is an emerging functional material for wide applications, but its feasible and scalable preparation remains a challenge. Herein, a high strength, flexible, and conductive graphene/polypropylene (PP) fiber paper was prepared by a traditional papermaking process. In the composite paper, graphene nanosheets were well stabilized on the PP fibers forming a stable three-dimensional conductive interleaved network. Chitosan was found able to build a polar active interface on PP fibers and graphene nanosheets, which can not only promote PP fiber dispersion in water yielding a uniform pulp, but also favor the retention of graphene in the composite paper. As a result, the composite paper presents high strength (15.32 MPa), good conductivity (11,995 S/m), shielding effectiveness (31.1 dB), water resistance, fungi-proof, and thermal conductivity (10.17 W m−1 k−1) properties. This work demonstrates the feasibility of large-scale preparation of graphene composite paper with commercial synthetic fibers through a traditional papermaking process, and expands the potential industrial application of graphene materials. Graphene/chitosan co-aggregates were absorbed on the surface of graphene/chitosan/PP fiber under the electrostatic interaction of CPAM to form graphene/PP fiber.
- Published
- 2021
7. New microfluidic paper-based analytical device for iron determination in urine samples
- Author
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Karina A. Catalão, António O. S. S. Rangel, Raquel B. R. Mesquita, Francisca T. S. M. Ferreira, and Veritati - Repositório Institucional da Universidade Católica Portuguesa
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Detection limit ,Sample blank correction ,Chromatography ,Chemistry ,Microfluidics ,Relative standard deviation ,Disposable device ,Urine ,Paper based ,Biochemistry ,Bathophenanthroline reaction ,Analytical Chemistry ,law.invention ,Absorbance ,Biological samples ,chemistry.chemical_compound ,Hydroxylamine ,Iron(II) and iron(III) content ,law ,Paper sensor ,Atomic absorption spectroscopy - Abstract
Iron is an important micronutrient involved in several mechanisms in the human body and can be an important biomarker. In this work, a simple and disposable microfluidic paper-based analytical device (µPAD) was developed for the quantification of iron in urine samples. The detection was based on the colorimetric reaction between iron(II) and bathophenanthroline and the reduction of iron(III) to iron(II) with hydroxylamine. The developed µPAD enabled iron determination in the range 0.07–1.2 mg/L, with a limit of detection of 20 µg/L and a limit of quantification of 65 µg/L, thus suitable for the expected values in human urine. Additionally, targeting urine samples, the potential interference of the samples color was overcome by incorporating a sample blank assessment for absorbance subtraction. Stability studies revealed that the device was stable for 15 days prior to usage and that the formed colored product was stable for scanning up to 3 h. The accuracy of the developed device was established by analyzing urine samples (#26) with the developed µPAD and with the atomic absorption spectrometry method; the relative deviation between the two sets of results was below 9.5%. Graphical abstract: [Figure not available: see fulltext.]
- Published
- 2021
8. Enhanced Conductivity and Flexibility in Reduced Graphene Oxide Paper by Combined Chemical-Thermal Reduction
- Author
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Kai Gao, Jiale Yang, Honglie Shen, Yan Yang, Xueming Ren, and Zehui Wang
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Materials science ,Graphene ,Scanning electron microscope ,Oxide ,Conductivity ,Nanoindentation ,Condensed Matter Physics ,Electronic, Optical and Magnetic Materials ,law.invention ,chemistry.chemical_compound ,chemistry ,law ,Electrical resistivity and conductivity ,Materials Chemistry ,Electrical and Electronic Engineering ,Composite material ,Thin film ,Graphene oxide paper - Abstract
Free-standing reduced graphene oxide (rGO) papers were prepared by chemical reduction, thermal reduction and combined chemical-thermal reduction, respectively. Four-point probe and nanoindentation experiments were conducted to investigate the electrical and mechanical properties of rGO papers. The rGO paper prepared by soaking in L-ascorbic acid and thermal annealing in argon at 1000 °C (labeled rGO-AsA-T) showed superior electrical and mechanical properties when compared with rGO papers prepared merely by chemical reduction or thermal reduction. The as-prepared rGO-AsA-T paper exhibited an electrical conductivity of 5.7 × 104 S/m, showing an increase of 90% compared to that in the thermally annealed rGO paper and nearly 40 times that of rGO paper reduced by L-ascorbic acid. It was also found that the rGO-AsA-T paper had the lowest elastic modulus of 288 MPa, showing enhanced flexibility. The nearly free voids in rGO-AsA-T paper proved by scanning electron microscopy (SEM) were due to the capillary action in chemical reduction and were significant in improving the electrical conductivity and flexibility of the paper. The rGO-AsA-T paper with high conductivity and flexibility has a promising application in flexible electronics.
- Published
- 2021
9. Self-assembled graphene oxide-based paper/hollow sphere hybrid with strong bonding strength
- Author
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Fan Wu, Yue Zhao, Ben Jiang, Chao Sui, Chao Wang, Junjiao Li, Huifeng Tan, Yifan Zhao, and Miao Linlin
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chemistry.chemical_classification ,Materials science ,Scanning electron microscope ,Graphene ,Oxide ,Nanotechnology ,02 engineering and technology ,General Chemistry ,Polymer ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Nanomaterials ,law.invention ,chemistry.chemical_compound ,Molecular dynamics ,chemistry ,law ,General Materials Science ,Wetting ,0210 nano-technology ,Graphene oxide paper - Abstract
Graphene-based nanomaterials possess broad applications because of their excellent multi-functional properties. In this work, a facile self-assembling method was presented for preparing one kind of graphene oxide-based paper/hollow microspheres hybrid. It was found that most of the hollow microspheres can strongly anchored on the surface of graphene oxide paper (GOP) by an in-situ scanning electron microscope peeling testing combining with molecular dynamics (MD) simulation. In addition, the uniform distribution of hollow microspheres on the surface of GOP cannot only provide a better surface wettability, but also can effectively improve the interfacial stress-transfer capability between such hybrid and polymer matrix. Our work provides a guidance for the structural designs of graphene-based nanomaterials and broaden their applications.
- Published
- 2021
10. Partial purification of bacterial cellulo-xylanolytic enzymes and their application in deinking of photocopier waste paper
- Author
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Jitender Sharma, Nishi Kant Bhardwaj, Sunita Dalal, Puneet Pathak, and Chakarvati Sango
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Paper ,Health, Toxicology and Mutagenesis ,Ultrafiltration ,Cellulase ,010501 environmental sciences ,engineering.material ,01 natural sciences ,law.invention ,law ,Environmental Chemistry ,Ammonium sulfate precipitation ,0105 earth and related environmental sciences ,Endo-1,4-beta Xylanases ,biology ,Chemistry ,Pulp (paper) ,General Medicine ,Pulp and paper industry ,Deinking ,Pollution ,Enzyme assay ,Folding endurance ,biology.protein ,Xylanase ,engineering ,Ink - Abstract
The potential of alkaline cellulo-xylanolytic enzymes from non-pathogenic Bacillus subtilis strain was tested for deinking of photocopier waste paper. Cellulase and xylanase play a crucial role in deinking of different types of waste paper. Partial purification of cellulo-xylanolytic enzymes was carried out using ultrafiltration followed by ammonium sulfate precipitation. The ultrafiltered enzyme was used for deinking the photocopier waste paper along with chemical deinking. An enzyme dose of 0.6 IU/g and reaction time of 60 min for ultrafiltered cellulo-xylanolytic enzyme significantly increased deinking efficiency, tear index (9.52%) and folding endurance (5±2%) as compared to chemical deinking. There was improvement in strength properties such as tear index and double-fold along with freeness of pulp (18%). There was slight decrease in tensile index (0.6%) and burst index (16%) while ISO brightness remained unaffected. Enzymatic deinking (74.3%) by ultrafiltered cellulo-xylanolytic from Bacillus subtilis was found significant over conventional chemical deinking.
- Published
- 2021
11. Prescribing Practices at a Residential Treatment Center – from Paper to Plastic (Computers)
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Jacob Tooley, Rachel Carpenter, Maya L Hubbard, Edmund B. Fanslau, Emily Hochstetler, Jeannie Ngo, Tyler Curry, and Michelle E. Roley-Roberts
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Pediatrics, Perinatology and Child Health ,Law - Published
- 2023
12. Women’s Rights After War on Paper: An Analysis of Legal Discourse
- Author
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Sinduja Raja
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History ,Sociology and Political Science ,Political Science and International Relations ,Law - Published
- 2023
13. Optimization of image writer modes for optically rewritable electronic paper
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Vladimir G. Chigrinov and Aleksey Kudreyko
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Materials science ,business.industry ,law ,Liquid crystal ,Optoelectronics ,General Materials Science ,General Chemistry ,Electronic paper ,Condensed Matter Physics ,business ,law.invention ,Image (mathematics) - Abstract
Time-limited exposure of electrode-free optically rewritable electronic paper is essential for applications, but performance characteristics can be modest. In this study we investigate whether imag...
- Published
- 2021
14. Religion and the Justification of Rights - Discussed: Faith, Freedom, and Family: New Studies in Law and Religion. By John Witte, Jr. Edited by Norman Doe and Gary S. Hauk. Tübingen: Mohr Siebeck, 2021. €99.00 (paper); €99.00 (digital). ISBN: 9783161608773. - The Blessings of Liberty: Human Rights and Religious Freedom in the Western Legal Tradition. By John WitteJr . Cambridge: Cambridge University Press, 2021. Pp. 316. $110.00 (cloth); $29.99 (paper); $24.00 (digital). ISBN: 9781108429207
- Author
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David Little
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Religious studies ,Law - Abstract
This review essay registers sincere appreciation for John Witte’s singular contribution to defending the importance of the history and interpretation of rights in the Western tradition, especially as related to Christian thought and practice. It also proposes to amend and refine his approach by highlighting the difference between natural and religious justifications of rights, and by suggesting reasons for favoring the former.
- Published
- 2023
15. Thermally Enhanced Boron Nitride Nanotube/reduced Graphene Oxide Paper and Their Application
- Author
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Dong Ick Son, Jaehyeon Lee, Joo Song Lee, and Jaeho Shim
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Materials science ,business.industry ,Graphene ,Oxide ,Buckypaper ,Durability ,Electronic, Optical and Magnetic Materials ,law.invention ,Nanomaterials ,chemistry.chemical_compound ,chemistry ,law ,Electromagnetic shielding ,Optoelectronics ,Thermal stability ,business ,Graphene oxide paper - Abstract
We demonstrated the thermally robust reduced graphene oxide (rGO)/boron nitride nanotube (BNNT) papers and their application in electromagnetic interference shielding. In order to overcome the thermal durability shortcomings of electromagnetic wave shielding paper based on rGO nanomaterial, rGO/BNNT electromagnetic interference (EMI) shielding paper having excellent thermal durability could be manufactured using BNNT nanomaterials having excellent chemical and thermal stability at high temperature. With the addition of a little BNNT, the durability against temperature can be increased by more than two times while there is little reduction in EMI performance.
- Published
- 2021
16. The 2018 Fisheries White Paper, the Fisheries Act 2020 and their international legal dimension
- Author
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Andrew Serdy
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White paper ,Political science ,Dimension (data warehouse) ,Intellectual property ,Fisheries Act ,Law ,Law and economics - Abstract
The 2018 Fisheries White Paper and the Fisheries Act 2020 were designed to govern United Kingdom (UK) fisheries management in the post-Brexit era irrespective of whether the UK and the European Union (EU) succeeded in settling their differences on fisheries and other matters that for much of 2020 made it uncertain whether the Trade and Cooperation Agreement could be concluded. This article considers several international legal issues raised by the White Paper and Fisheries Act, including the choices made by the UK as to which regional fisheries management organisations to (re)join now that the EU no longer speaks for the UK within them, and the treaty processes for doing so, before moving on to further matters given only sketchy treatment in, or omitted altogether from, those documents, on which a firmer position ought to have been taken. Lastly, a new problem apparent for the first time in the Fisheries Act is discussed: navigational freedom of foreign fishing vessels in the UK's exclusive economic zone, and a missed opportunity to legislate a related evidential presumption that would assist future prosecutions for illegal fishing.
- Published
- 2021
17. High-strength reduced graphene oxide paper prepared by a simple and efficient method
- Author
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Wenzhong Yang, Liming Shen, Ningzhong Bao, Chengjie Weng, and Wen Li
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Materials science ,Graphene ,Mechanical Engineering ,Oxide ,Graphite oxide ,Conductivity ,engineering.material ,Exfoliation joint ,law.invention ,chemistry.chemical_compound ,chemistry ,Coating ,Mechanics of Materials ,law ,Ultimate tensile strength ,engineering ,General Materials Science ,Composite material ,Graphene oxide paper - Abstract
Excellent mechanical and electrical properties of graphene-based paper-like materials are essential for applications in flexible conductors, energy-storage devices, etc. The graphene oxide (GO) supernatant separated by centrifugation and ultrasonication has been used to prepare graphene oxide paper and reduced graphene oxide paper (rGOP) with high strength and conductivity. However, this method has cumbersome steps and low supernatant concentration, which greatly increases time and energy consumption, and is not suitable for rapid batch preparation of high-strength and high-thickness rGOP. Herein, a high-speed mechanical shearing method has been used to efficiently exfoliate graphite oxide suspension into high-concentration GO slurry with large lateral size, and rGOP has been further prepared by blade coating and HI acid chemical reduction. Compared with the product prepared by ultrasonic exfoliation method, the average area of GO sheets obtained via the mechanical shear exfoliation method can reach around 16.31 μm2. As a result, the mechanical properties and conductivity of the prepared rGOP have been increased by 30% and 23.5%, respectively, with the tensile strength and electrical conductivity of 478.2 MPa and 208.4 S/cm being obtained. The developed method is of great significance for the large-scale production and emerging applications of lightweight and high-performance rGOP.
- Published
- 2021
18. Filtration efficiency improvement of air filter paper for fine particles by electrospinning technology
- Author
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Wan-hong Sun, Lanfeng Hui, Weiyin Su, Qian Yang, and Xiaoyan Ma
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Environmental Engineering ,business.product_category ,Materials science ,Filter paper ,Bioengineering ,Electrospinning ,law.invention ,law ,Nanofiber ,Air permeability specific surface ,Microfiber ,Composite material ,business ,Waste Management and Disposal ,Spinning ,Filtration ,Air filter - Abstract
Due to great advantages, such as simple operation, high porosity, and good fiber continuity, the working principle and research progress of electrospinning technology was studied and polyvinyl alcohol (PVOH) nanofibers were prepared via this process. Air filter paper was used as the receiving substrate to prepare electrospun nano air filter paper (NAFP). The PVOH concentration, static voltage, and receiving distance, were tested to explore the influence of spinning parameters on the filtration performance. Further, the microfiber morphology of the electrospun NAFP was observed. The performance of filter paper, including air permeability, pore size, initial resistance, filtration efficiency, and dust retention, were tested. The results showed that the electrospun NAFP had better filtration performance compared to the air filter paper, and simultaneously they had lower initial resistance and higher precision filtration efficiency. The nanofiber influenced the surface of the air filter paper, as it sharply reduced the pore size. When the spinning condition was 10%, 21 kV, and 15 cm, the pore size decreased approximately 0.6 times of the original, which meant the electrospun NAFP could capture particles ≥ 0.2 μm in size. Finally, after three repeated uses, the good filtration performance was maintained.
- Published
- 2021
19. Electrochemical technique for paper mill effluent degradation using concentric aluminum tube electrodes (CATE)
- Author
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Chandrashekhar Basayya Shivayogimath and Prashant Basavaraj Bhagawati
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Environmental Engineering ,Materials science ,Health, Toxicology and Mutagenesis ,02 engineering and technology ,010501 environmental sciences ,01 natural sciences ,Applied Microbiology and Biotechnology ,law.invention ,Taguchi methods ,020401 chemical engineering ,law ,0204 chemical engineering ,Turbidity ,Waste Management and Disposal ,Effluent ,0105 earth and related environmental sciences ,Water Science and Technology ,Electrolysis ,business.industry ,Chemical oxygen demand ,Public Health, Environmental and Occupational Health ,Paper mill ,Pulp and paper industry ,Pollution ,Electrode ,Orthogonal array ,business ,Research Article - Abstract
In this study, Taguchi experimental design was used to the optimize operating parameters for the degradation of paper mill effluent using electrochemical (EC) process with two-dimensional concentric aluminum tube electrodes (CATE). For this purpose, four significant experimental factors were used in four levels pH (6–9), electrolysis time (10–40 min), voltage (6–12 V) and surface area (357–624 cm(2)). The process parameters were optimized, through performing L16 orthogonal array of Taguchi technique, for the removal of chemical oxygen demand (COD) and turbidity. The percent COD and turbidity reductions were transferred into an accurate S/N ratio for a larger value is the better (LBT) response. The study presents a unique method of finding optimum combination of process parameters to illustrate their effect on the turbidity and COD reduction. The treatment conditions for the maximum elimination of the pollutants were second level of pH (7), third level of ET (30 min), fourth level of voltage (12 V) and second level of surface area (446 cm(2)). The confirmation experiment results were within the confidence intervals (CI) indicating an acceptable agreement between predicted and observed values. Based on the p-values, the electrolysis time and voltages were found to be the most significant factors for both COD and turbidity reduction. The findings of research indicated, that the Taguchi method can be used successfully for the treatment of paper industry effluent by electrochemical technique.
- Published
- 2021
20. Rapid Detection of Synthetic Cannabinoid Receptor Agonists Impregnated into Paper by Raman Spectroscopy
- Author
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Thomas Coombs, Amor Abdelkader, Dhiya Al-Jumeily, and Sulaf Assi
- Subjects
Epidemiology ,Biochemistry (medical) ,Toxicology ,Law ,Pathology and Forensic Medicine - Abstract
English The last decade has witnessed the emergence of new psychoactive substances that are analogues of classical drugs of abuse in order to escape the regulations surrounding the latter drugs. These drugs were of both herbal and synthetic origin and were advertised initially as ‘legal highs’; thus, they were perceived as safe by users. Hence, upon their emergence, they were not controlled by the Misuse of Drugs Act 1971, which contributed to their popularity and increased sales online and within street markets. In 2016, the Psychoactive Substance Act introduced a blanket ban on all new psychoactive substances except for caffeine, alcohol, and nicotine. This in turn, contributed to the change in the sale of new psychoactive substances products that have been sold as concealed in different matrices, including herbal products, papers, fabrics, and textiles. Concealing drugs in paper has been very popular, especially since the drug product is of lightweight and can be sent via postal services. However, new psychoactive concealed in papers are toxic not only to the users; but also, to the person handling them (i.e. mail employees). One of the classes of new psychoactive substances that have been commonly concealed in papers and that have been linked to toxicity and hospitalization cases is synthetic cannabinoids. Therefore, there is a need to identify new psychoactive substances concealed in papers non-destructively and rapidly to prevent toxicity linked to them. Handheld Raman spectroscopy offers this advantage as it is of lightweight and carries the sample to the matrix. Therefore, this work used handheld Raman spectroscopy for identifying synthetic cannabinoids concealed in papers using Raman spectroscopy combined with machine learning analytics. Synthetic cannabinoid and paper samples were measured non-destructively using a handheld Raman spectrometer equipped with a 1064 nm laser wavelength. Spectral data was exported into Matlab 2020b where machine learning analytics including identification and prediction was. The results showed that Raman spectroscopy could identify specific synthetic cannabinoids in papers that were either deposited on the surface of the paper or diffused inside the paper substrate. When machine learning analytics were applied to the Raman spectra of the papers, quantitative information was obtained regarding the amount of synthetic cannabinoid deposited on the paper surface. In summary, handheld Raman spectroscopy could identify and quantify synthetic cannabinoids on paper rapidly and non-destructively. Future work involves testing other classes of new psychoactive substance and applying deep learning analytics
- Published
- 2022
21. Characteristics of calcium lignin from pulping waste liquor and application for the treatment middle-stage wastewater of paper making
- Author
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Hao Yang, Guangzai Nong, Yijing Li, and Tian Zhu
- Subjects
Sodium ,chemistry.chemical_element ,macromolecular substances ,engineering.material ,Calcium ,complex mixtures ,law.invention ,chemistry.chemical_compound ,symbols.namesake ,Adsorption ,law ,Environmental Chemistry ,Lignin ,Calcination ,Waste Management and Disposal ,Water Science and Technology ,Lime ,fungi ,technology, industry, and agriculture ,food and beverages ,Langmuir adsorption model ,General Medicine ,Pulp and paper industry ,chemistry ,Wastewater ,engineering ,symbols - Abstract
In order to obtain a lignin-based adsorbent with low cost, simple operation and no further modification, a calcium lignin adsorbent was prepared from chemical mechanical pulping (CMP) waste liquor by directly calcification from lime. The calcium lignin was characterized by BET, SEM, TEM, FT-IR and solid-state NMR analyses. The results showed that the molecular structure of the calcium lignin particles did not change when compared to sodium lignin, the formation mechanism of calcium lignin was revealed. The initial COD and lignin contents of CMP waste liquid were 54858 mg/L and 24.39 g/L, the conversion rate of lignin can reach 71.36% when was deal with lime. Thus, most of the lignin resources in the waste liquid were recovered. The middle-stage wastewater (MSWW) of pulping and papermaking was dealt with calcium lignin, the COD removal rate was up to 85.83%. The adsorption isotherms and kinetics were well fitted by the Langmuir model and pseudo-second-order kinetic model, respectively. Lime was regenerated from the used calcium lignin with high-temperature calcination, the conversion rate of calcium ions can reach 83.56%. Overall, the calcium lignin prepared by the one-step method exhibited great potential for effectively removing COD from middle-stage wastewater.
- Published
- 2021
22. Preparation and characterization of colorful graphene oxide papers and flexible N‐doping graphene papers for supercapacitor and capacitive deionization
- Author
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Ying Yuan, Haichuan Zhang, Hao Zhang, Di Zheng, Geng Zhuning, Fang Zhang, Guanghe Li, Aiyang Li, and Yuquan Wei
- Subjects
Supercapacitor ,TK1001-1841 ,Materials science ,Renewable Energy, Sustainability and the Environment ,Graphene ,Capacitive deionization ,energy storage ,Materials Science (miscellaneous) ,Doping ,colorful graphene oxide ,Oxide ,Nanotechnology ,Energy storage ,Characterization (materials science) ,law.invention ,chemistry.chemical_compound ,Production of electric energy or power. Powerplants. Central stations ,chemistry ,law ,Materials Chemistry ,supercapacitor ,Energy (miscellaneous) ,flexible graphene paper ,N‐doped graphene - Abstract
An efficient method that utilizes simple techniques, easy operation, and low‐cost production to create flexible graphene‐based materials is a worthy practical challenge. A rapid strategy for preparing flexible, functional graphene oxide (GO) is introduced using GO‐ethanol dispersion filtration. The filtration process is highly efficient and drying time is significantly reduced by employing ethanol as solvent, due to the fact that ethanol is a volatile liquid. Freestanding GO papers can be harvested with ultralarge size (700 cm2), color variety, and writable characteristics. After reduction, N‐doped graphene (NDG) papers still maintain good foldability with improved electric conductivity and porous structure. When used as an electrode for a supercapacitor, the flexible NDG paper device demonstrates good electrochemical performance even with size expansion and extreme double folding. Moreover, this NDG paper capacitor device shows a good electrosorption performance for capacitive deionization of sulfate and chromate in groundwater system. These flexible GO and NDG papers promise potential to facilitate the production of graphene‐based materials for practical applications in energy and environmental related fields.
- Published
- 2020
23. The legal content of a white paper for an ICO (initial coins offering)
- Author
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Sergey Kasatkin
- Subjects
White (horse) ,Smart contract ,Communication ,media_common.quotation_subject ,Advertising ,computer.file_format ,Certainty ,Security token ,Computer Science Applications ,White paper ,ICO ,Business ,Content (Freudian dream analysis) ,Law ,computer ,media_common - Abstract
Clear legal content of white papers provides certainty, stability and trust in the relations between all the participants in initial coins offering (ICO) procedures and contributes to the successfu...
- Published
- 2021
24. Fabrication of flexible graphene oxide paper-like adsorbent doped with magnetite nanoparticles for removal of dyes
- Author
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Yunus Burçhan Kontaş, Murat Alanyalıoğlu, and Elif Erçarıkcı
- Subjects
Materials science ,Absorption spectroscopy ,010405 organic chemistry ,Graphene ,Oxide ,General Chemistry ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences ,law.invention ,chemistry.chemical_compound ,Adsorption ,chemistry ,Chemical engineering ,X-ray photoelectron spectroscopy ,law ,Methyl orange ,Fourier transform infrared spectroscopy ,Graphene oxide paper - Abstract
Organic dyes are used in many industries, e.g., textile, cosmetics and food. Hence, contamination of organic dyes to water sources is a critical issue. To reduce water pollution by organic dyes, we propose a paper-like adsorbent with a practical and economical production procedure. Subsequently, a flexible adsorbent was produced using a one-step approach by vacuum filtration of graphene oxide (GO) and iron oxide nanoparticles (Fe3O4-NPs) containing dispersion through a membrane and quoted as GO/Fe3O4 paper. For comparison, GO paper was also prepared using the same procedure. Both papers were characterized using UV–VIS absorption spectroscopy, Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscopy, electron diffraction X-ray analysis, X-ray photoelectron spectroscopy, and powder X-ray diffraction techniques. At the steady-state conditions, GO/Fe3O4 and GO papers were performed as adsorbent for cationic dyes of methylene blue, neutral red, and anionic dyes of methyl orange and fluorescein. In general, the removal efficiency of GO/Fe3O4 paper was higher than that of GO paper for adsorption of all dyes and this adsorbent revealed satisfactory adsorption properties for cationic dyes when compared to anionic dyes.
- Published
- 2021
25. Effects of Flame Retardant on the Flammability of Treated and Untreated Bagasse Papers
- Author
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E. C. Nwokoro, F. O. Nnaneme, and T. U. Onuegbu
- Subjects
Materials science ,Alum ,Pulp and paper industry ,complex mixtures ,law.invention ,Ignition system ,chemistry.chemical_compound ,chemistry ,law ,Management of Technology and Innovation ,Hemicellulose ,Cellulose ,Bagasse ,Fire retardant ,Flammability - Abstract
A comparative study of the proximate analysis, fire characteristics, and mechanical properties of the papers produced from pretreated and untreated bagasse was carried out. The bagasse collected was washed, dried, depithed and ground to pass through a 5 mm sieve using an electric milling machine. A portion was pulped without pretreatment, while others were pretreated (acetylation) before pulping and washing. After which different mass (0,2,4,6,8 and 10 g) of potassium aluminum sulphate, KAl(SO4)2.12H2O (alum) as flame retardant was added. The proximate analysis, fire characteristics and mechanical properties were determined. Results show that cellulose content increased with an increase in the concentration of potassium aluminum sulphate, while hemicellulose content increased from 24%-34% for flame retarded paper with 0-10 g concentration of alum. Lignin content also increased from 21.3%-63.2% for flame retarded paper with 0-10 g concentration of alum, respectively. Ash content varied with an increase in the concentration of potassium aluminum sulphate. Results from fire characteristics show that flame propagation and flame duration rate decreased with an increase in the concentration of alum, while ignition time and char formation increased in the concentration of alum. The mechanical properties, tensile strength, modulus and elongation at break were enhanced. Conclusively, pretreatment enhanced the properties of bagasse papers produced.
- Published
- 2021
26. The Research and Application of System for Paper Surface Morphology Stereoscopic Observation and Characterization
- Author
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Haozhi Chen, Guangxue Chen, and Tingli Liu
- Subjects
Surface (mathematics) ,Materials science ,business.industry ,Point cloud ,Morphology (biology) ,Stereoscopy ,Paper quality ,Characterization (materials science) ,law.invention ,Microscopic observation ,Optics ,Artificial Intelligence ,Control and Systems Engineering ,law ,business ,Software ,Information Systems - Abstract
The work aims to explore a microscopic observation system of paper surface and achieve high-precision stereoscopic observation with detail characterization of paper surface morphology. Based on the DT-400E precision program-controlled three-dimensional translation stage and KEYENCE LJV-7200 two-dimensional laser scanner, the hardware parts of our own system are developed to scan and transmit point cloud data of paper surface morphology to the computer. The corresponding system software will automatically process the point cloud data acquired from the laser scanner and generate the corresponding vivid 3D model and height histogram. This system scans and characterizes four different types of paper samples, allowing the human eye to visually distinguish the differences in surface morphology as well as automatically calculate the numerical differences in paper surface morphology parameters. The results of the applicability test show that the system is highly efficient in acquiring, observing, and evaluating the topography of the paper surface. The system can not only predict the paper surface quality of printed paper, but can also be extended to the evaluation of 3D printed surfaces.
- Published
- 2021
27. Electroanalytical Sensor Based on Gold-Nanoparticle-Decorated Paper for Sensitive Detection of Copper Ions in Sweat and Serum
- Author
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Simona Roggero, Neda Bagheri, Paolo A. Netti, Vincenzo Mazzaracchio, Stefano Cinti, Danila Moscone, Noemi Colozza, Mohammad Saraji, Fabiana Arduini, Concetta Di Natale, Bagheri, N., Mazzaracchio, V., Cinti, S., Colozza, N., Di Natale, C., Netti, P. A., Saraji, M., Roggero, S., Moscone, D., and Arduini, F.
- Subjects
Analyte ,Microfluidics ,Metal Nanoparticles ,Nanoparticle ,chemistry.chemical_element ,Nanotechnology ,Biosensing Techniques ,Standard solution ,010402 general chemistry ,01 natural sciences ,Analytical Chemistry ,law.invention ,Biosensing Technique ,law ,Ion ,Sweat ,Ions ,Filter paper ,010401 analytical chemistry ,Copper ,0104 chemical sciences ,chemistry ,Reagent ,Gold ,Atomic absorption spectroscopy - Abstract
The growth of (bio)sensors in analytical chemistry is mainly attributable to the development of affordable, effective, portable, and user-friendly analytical tools. In the field of sensors, paper-based devices are gaining a relevant position for their outstanding features including foldability, ease of use, and instrument-free microfluidics. Herein, a multifarious use of filter paper to detect copper ions in bodily fluids is reported by exploiting this eco-friendly material to (i) synthesize AuNPs without the use of reductants and/or external stimuli, (ii) print the electrodes, (iii) load the reagents for the assay, (iv) filter the gross impurities, and (v) preconcentrate the target analyte. Copper ions were detected down to 3 ppb with a linearity up to 400 ppb in standard solutions. The applicability in biological matrices, namely, sweat and serum, was demonstrated by recovery studies and by analyzing these biofluids with the paper-based platform and the reference method (atomic absorption spectroscopy), demonstrating satisfactory accuracy of the novel eco-designed analytical tool.
- Published
- 2021
28. Filter paper based SERS substrate for the direct detection of analytes in complex matrices
- Author
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Xinyuan Li, Steven E. J. Bell, Qinglu Chen, Wesley R. Browne, Harmke S. Siebe, Yikai Xu, and Molecular Inorganic Chemistry
- Subjects
chemistry.chemical_classification ,Analyte ,Materials science ,Silver ,Filter paper ,Polymers ,Analytical technique ,Substrate (chemistry) ,Polymer ,Thiram ,Spectrum Analysis, Raman ,Biochemistry ,Analytical Chemistry ,law.invention ,Matrix (chemical analysis) ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,law ,Electrochemistry ,Environmental Chemistry ,Spectroscopy ,Filtration ,Hydroxyethyl cellulose - Abstract
Surface-enhanced Raman spectroscopy (SERS) is an emerging analytical technique for chemical analysis, which is favourable due to its combination of short measurement time, high sensitivity and molecular specificity. However, the application of SERS is still limited, largely because in real samples the analyte is often present in a complex matrix that contains micro/macro particles that block the probe laser, as well as molecular contaminants that compete for the enhancing surface. Here, we show a simple and scalable spray-deposition technique to fabricate SERS-active paper substrates which combine sample filtration and enhancement in a single material. Unlike previous spray-deposition methods, in which simple colloidal nanoparticles were sprayed onto solid surfaces, here the colloidal nanoparticles are mixed with hydroxyethyl cellulose (HEC) polymer before application. This leads to significantly improved uniformity in the distribution of enhancing particles as the film dries on the substrate surface. Importantly, the polymer matrix also protects the enhancing particles from air-oxidation during storage but releases them to provide SERS enhancement when the film is rehydrated. These SERS-paper substrates are highly active and a model analyte, crystal violet, was detected down to 4 ng in 10 μL of sample with less than 20% point-by-point signal deviation. The filter paper and HEC effectively filter out both interfering micro/macro particles and molecular (protein) contaminants, allowing the SERS-paper substrates to be used for SERS detection of thiram in mud and melamine in the presence of protein down to nanogram levels without sample pre-treatment or purification.
- Published
- 2021
29. Enzymatic deinking of office waste printed paper: optimization via response surface methodology
- Author
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Maryam Ataeefard, S Mahdavi, Seyed Masoud Etezad, and Bahareh Ghanbarzadeh
- Subjects
Materials science ,Renewable Energy, Sustainability and the Environment ,020209 energy ,02 engineering and technology ,Paper based ,010501 environmental sciences ,Optical density ,Pulp and paper industry ,Deinking ,01 natural sciences ,law.invention ,Process conditions ,Interactive effects ,law ,Ultimate tensile strength ,0202 electrical engineering, electronic engineering, information engineering ,Fiber ,Response surface methodology ,0105 earth and related environmental sciences - Abstract
In traditional deinking process, large amounts of chemicals are required which makes these methods expensive and polluting. Also, application of sustainable material implies the use of green processes to reduce waste and pollution. Green enzymatic deinking processes are alternatives to those technologies that have negative effects on the environment. In this work, we applied response surface methodology for deinking the electrophotography-printed paper based on a systematic experimental pattern. The individual and interactive effects of enzymatic deinking parameters including time, temperature, and enzyme dosage on the handsheet properties were investigated. Different analyses were carried out to determine the best process conditions of enzymatic deinking to optimize the handsheet properties (i.e., tensile, burst, whiteness, and brightness). The obtained responses of an oven-dried fiber at 45 min, 43 °C and the enzyme concentration of 1 mg/15 g were 12.44, 0.65, 72.20, and 87 for tensile strength, burst strength, whiteness, and brightness, respectively. Measuring the optical density of the deinked handset after printing showed that the printability of the deinked paper is in the desired range.
- Published
- 2021
30. Theoretical analysis of de-inking methodology and process improvement initiatives in paper industry
- Author
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M. Karthikeyan and S. Krishnamoorthy
- Subjects
010302 applied physics ,Printing ink ,Process (engineering) ,Pulp (paper) ,media_common.quotation_subject ,Process improvement ,02 engineering and technology ,engineering.material ,Raw material ,021001 nanoscience & nanotechnology ,Deinking ,Pulp and paper industry ,01 natural sciences ,law.invention ,Cellulose fiber ,law ,0103 physical sciences ,engineering ,Environmental science ,Quality (business) ,0210 nano-technology ,media_common - Abstract
Virgin pulp is made by splitting up cellulose fibers from the woods by mechanical and chemical process without adding any recycled pulp content. The demand for trees, which are the basic raw material for making virgin pulp, increasing constantly in enormously growing paper manufacturing industry. The paper, which is made from virgin pulp is called as virgin paper and this is considered as better quality paper than the recycled paper. Now there is a need to increase the quality of recycled paper to equalize the quality of virgin paper, to reduce the demand for trees to make virgin pulp. In recycling, dispersive system is responsible for the de-inking process, which is one of the pulp purifying process which removes the printing ink from fibers. Chemicals are added in this deinking process which causes a serious problem by increasing the chemical concentration level of industrial outlet water. In conventional deinking technology, dispersive system is controlled by DCS which is quite complicated to control complex loop of operations. To overcome these problems, the dispersive system operations are controlled by PLC along with sensors which make the process easier and replacing the chemicals with enzymes will reduce the chemical concentration level of industrial outlet water and increases the quality of paper.
- Published
- 2021
31. Enhanced Power Density of Alcohol Biofuel Cell by Polymer‐assisted Crosslinks of 3D Graphene on Carbon Paper as the Bioanode
- Author
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Ling Zhang, Yuhe Shi, and Lin Li
- Subjects
chemistry.chemical_classification ,Materials science ,business.product_category ,Graphene ,Atomic force microscopy ,Alcohol ,Polymer ,Analytical Chemistry ,law.invention ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,law ,Biofuel ,Electrochemistry ,Carbon paper ,business ,Power density - Published
- 2021
32. Valorification of Ulva rigida Algae in Pulp and Paper Industry for Improved Paper Characteristics and Wastewater Heavy Metal Filtration
- Author
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Alina Cantaragiu Ceoromila, Florina-Cristiana Caprita, and Antoaneta Ene
- Subjects
Grammage ,Absorption of water ,Materials science ,Geography, Planning and Development ,TJ807-830 ,Management, Monitoring, Policy and Law ,TD194-195 ,beach wrack ,Renewable energy sources ,law.invention ,Industrial wastewater treatment ,law ,valorification ,filter paper ,GE1-350 ,heavy metals ,Filtration ,stranded macroalgae ,filtration ,Filter paper ,Moisture ,Environmental effects of industries and plants ,Renewable Energy, Sustainability and the Environment ,physical–mechanical properties ,Pulp and paper industry ,Folding endurance ,Environmental sciences ,Wastewater - Abstract
This paper presents preliminary results on the possibility of incorporating stranded macroalgae into the papermaking process, analyses of the physical-mechanical properties of filter paper, with the addition of stranded macrophytic marine algae from Ulva rigida species obtained previously, results of SEM–EDX analyses of filter paper samples, and results obtained from the filtration of a wastewater from the metallurgical industry, using the improved filter paper samples. In the filter paper recipe, stranded macrophytic seaweed of the species Ulva rigida was added at different percentages of 0.5%, 1%, 2%, 4% and 8%, and the addition was calculated in relation to the absolute dry material. The physicomechanical properties analyzed are grammage, thickness, density, moisture, ash content, breaking load, breaking length, tear resistance, bursting resistance, folding endurance, porosity, smoothness, water absorption and Cobb60 index. Additional information related to the homogeneity of the distribution of elements in the paper mass was obtained by scanning electron microscopy with energy-dispersive X-ray analysis (SEM–EDX). The addition of macroalgae to the paper mass improved the strength characteristics of the paper, such as breaking load, breaking length, tearing resistance, folding endurance and water absorption. Following industrial wastewater filtration using filter paper with added seaweed, positive results were obtained in terms of reduction of total Cr, Cu, total Fe and Zn concentrations.
- Published
- 2021
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33. Flexible, Robust, and Durable Aramid Fiber/CNT Composite Paper as a Multifunctional Sensor for Wearable Applications
- Author
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Shunxi Song, Xueyao Ding, Nie Jingyi, Bin Yang, Meiyun Zhang, Lin Wang, and Jiaojun Tan
- Subjects
Paper ,Imagination ,Materials science ,Chemical substance ,Polymers ,media_common.quotation_subject ,Composite number ,Phthalic Acids ,Biosensing Techniques ,02 engineering and technology ,Carbon nanotube ,Phenylenediamines ,010402 general chemistry ,01 natural sciences ,law.invention ,Motion ,Wearable Electronic Devices ,law ,Humans ,General Materials Science ,Monitoring, Physiologic ,media_common ,Nanotubes, Carbon ,business.industry ,Electric Conductivity ,Response time ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Electric heating ,Optoelectronics ,0210 nano-technology ,business ,Joule heating ,Voltage - Abstract
Flexible paper-based sensors may be applied in numerous fields, but this requires addressing their limitations related to poor thermal and water resistance, which results in low service life. Herein, we report a paper-based composite sensor composed of carboxylic carbon nanotubes (CCNTs) and poly-m-phenyleneisophthalamide (PMIA), fabricated by a facile papermaking process. The CCNT/PMIA composite sensor exhibits an ability to detect pressures generated by various human movements, attributed to the sensor's conductive network and the characteristic "mud-brick" microstructure. The sensor exhibits the capability to monitor human motions, such as bending of finger joints and elbow joints, speaking, blinking, and smiling, as well as temperature variations in the range of 30-90 °C. Such a capability to sensitively detect pressure can be realized at different applied frequencies, gradient sagittas, and multiple twists with a short response time (104 ms) even after being soaked in water, acid, and alkali solutions. Moreover, the sensor demonstrates excellent mechanical properties and hence can be folded up to 6000 times without failure, can bear 5 kg of load without breaking, and can be cycled 2000 times without energy loss, providing a great possibility for a long sensing life. Additionally, the composite sensor shows exceptional Joule heating performance, which can reach 242 °C in less than 15 s even when powered by a low input voltage (25 V). From the perspective of industrialization, low-cost and large-scale roll-to-roll production of the paper-based sensor can be achieved, with a formed length of thousands of meters, showing great potential for future industrial applications as a wearable smart sensor for detecting pressure and temperature, with the capability of electric heating.
- Published
- 2021
34. Detection of adulteration in sunflower oil using paper-based microfluidic lab-on-a-chip devices
- Author
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R. Muthukumar, Vijay Vaishampayan, Sivasamy Balasubramanian, Mihul Gabhane, and Ashish Kapoor
- Subjects
010302 applied physics ,food.ingredient ,business.industry ,Computer science ,Sunflower oil ,Microfluidics ,02 engineering and technology ,Paper based ,Lab-on-a-chip ,021001 nanoscience & nanotechnology ,01 natural sciences ,law.invention ,food ,law ,0103 physical sciences ,Palm oil ,0210 nano-technology ,Process engineering ,business - Abstract
Edible oils form an integral component in the human diet as well as in the industrial preparations. Any adulteration in oil is concerning from nutritional as well as economical perspective. Although analytical techniques exist for detection of adulterants in oil, most of them require sophisticated instruments, and trained professionals. Microfluidic based lab-on-a-chip technologies have rapidly progressed over the recent years and offer promising alternatives in this regard. In this work, we report development of a paper-based microfluidic lab-on-a-chip for detection of palm oil contamination in sunflower oil. We use the paper-based microfluidic colorimetric detection approach that indicates the presence of adulteration in a visual manner. The data is analyzed using digitally acquired images along with ultraviolet–visible spectrophotometry. The paper-based microfluidic device is fabricated and tested for 10–50% (v/v) palm oil adulteration in sunflower oil. Further, we employ the device for free fatty acid content tests in oil samples. Visual signal acquired from the device is optimized by varying phenolphthalein proportions. The stability of visual colorimetric signal is examined over time and is found to remain steady over the trial period of six days considered in this work. The integration of the detection device with smartphone imaging can prove to be useful for onsite data collection. We believe the approach presented here can be extended to food quality monitoring portable platforms.
- Published
- 2021
35. Influence of Aging on Creepage Discharge Characteristics of Oil-Paper Insulation Under AC-DC Combined Voltage
- Author
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Liang Bin, Zhou Yuanxiang, and Jin Fubao
- Subjects
Aging ,Materials science ,General Computer Science ,020209 energy ,02 engineering and technology ,01 natural sciences ,law.invention ,Dc voltage ,law ,0103 physical sciences ,0202 electrical engineering, electronic engineering, information engineering ,Arc flash ,creepage discharge ,General Materials Science ,Composite material ,Transformer ,010302 applied physics ,AC-DC combined voltage ,General Engineering ,inception voltage ,Electrode ,oil-paper insulation ,lcsh:Electrical engineering. Electronics. Nuclear engineering ,Stage (hydrology) ,DC voltage component ,lcsh:TK1-9971 ,Voltage - Abstract
There is a relative lack of research on the development of creepage discharge in aged oil-paper insulation subjected to AC-DC combined voltage in converter transformers. In this study, based on the physical and chemical properties of oil-paper, we propose a sphere-plate electrode model to study the creepage discharge parameters and characteristic spectra of aged oil-paper subjected to AC-DC combined voltage. The results show that the creepage discharge inception voltage of aged oil-paper is related to the AC voltage component of the AC-DC combined voltage. However, when the DC voltage component is 60 kV, the flashover phenomenon was found to occur in one of the severely aged samples before the AC voltage was applied. Despite being subjected to the same DC voltage, the flashover phenomenon did not occur in three other samples aged to different degrees. Large-amplitude discharges were found to appear earlier in the severely aged samples. At the same creepage discharge stage, as the aging time of the oil-paper increased, the number of large-amplitude discharges was found to rapidly increase, and the time interval between adjacent discharges was found to gradually decrease. At each stage of the creepage discharge, the small-amplitude discharge has a “hump” shaped distribution. The larger the DC voltage component, the shorter the endurance time of aged oil-paper, and the more severe the damage to the oil-paper. The DC voltage component was found to have an accelerating effect on the development of creepage discharge in aged oil-paper insulation.
- Published
- 2021
36. An origami paper-based nanoformulated immunosensor detects picograms of VEGF-C per milliliter of blood
- Author
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Yu Xing, Tao Ming, Jinping Luo, Shi Yan, Yuanyuan Ma, Juntao Liu, Yue Yang, Ying Xiong, Yang Wang, Shuai Sun, and Xinxia Cai
- Subjects
Paper ,QH301-705.5 ,VEGF receptors ,Microfluidics ,Vascular Endothelial Growth Factor C ,Medicine (miscellaneous) ,Nanoparticle ,Metal Nanoparticles ,02 engineering and technology ,Carbon nanotube ,Biosensing Techniques ,010402 general chemistry ,01 natural sciences ,General Biochemistry, Genetics and Molecular Biology ,Article ,law.invention ,Nanocomposites ,Cancer screening ,Tumour biomarkers ,chemistry.chemical_compound ,Blood serum ,law ,Limit of Detection ,Lab-On-A-Chip Devices ,Neoplasms ,Biomarkers, Tumor ,Humans ,Biology (General) ,Electrodes ,Early Detection of Cancer ,Detection limit ,Immunoassay ,biology ,Chemistry ,Nanotubes, Carbon ,New methylene blue ,Electrochemical Techniques ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Colloidal gold ,biology.protein ,Microtechnology ,Nanoparticles ,Gold ,0210 nano-technology ,General Agricultural and Biological Sciences ,Blood Chemical Analysis ,Biomedical engineering - Abstract
Detecting vascular endothelial growth factor C (VEGF-C), a kind of tumor biomarker, is of significant clinical importance in evaluating the prognosis of patients with cancer. However, laboratory analyses are usually not suitable for point-of-care testing because they are expensive and time consuming. In response to these challenges, we fabricated an origami paper-based microfluidic electrochemical device. To improve the specificity of VEGF-C detection, nanocomposites, synthesized by new methylene blue (NMB), amino-functional single-walled carbon nanotubes (NH2-SWCNTs), and gold nanoparticles (AuNPs), were used to modify the surface of working electrodes. Results of electrochemical detection showed that the immunosensor had excellent linearity, ranging from 0.01 to 100 ng mL−1 (R2 = 0.988), and the limit of detection was 10 pg mL−1. To confirm the high specificity of the device under real-world conditions, we evaluated the device using clinical serum samples from our hospital. The results demonstrated that the device had an excellent performance and could provide a platform for real-time detection of cancers., Sun, Wang et al. report an origami paper-based immunosensor for the electrochemical detection of the VEGF-C biomarker in blood serum. The immunosensor is made by modifying the surface of working electrodes with new methylene blue, amino-functional single-walled carbon nanotubes, and gold nanoparticles and demonstrates excellent performance with a limit of detection in the range of picograms per milliliter.
- Published
- 2021
37. The Afghanistan Papers: A Secret History of the War; Eagle Down: American Special Forces at the End of Afghanistan's War
- Author
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William Layer
- Subjects
Economics and Econometrics ,Political Science and International Relations ,Geography, Planning and Development ,Law - Published
- 2023
38. Religious Liberty and Human Rights: Their Origin, Their Development in the Anglo-American Legal Tradition, and Why They Are Still Needed - Discussed: The Blessings of Liberty: Human Rights and Religious Freedom in the Western Legal Tradition. By John WitteJr . Cambridge: Cambridge University Press, 2021. Pp. 316. $110.00 (cloth); $29.99 (paper); $24.00 (digital). ISBN: 9781108429207
- Author
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Ian Leigh
- Subjects
Religious studies ,Law - Abstract
John Witte, Jr.’s book The Blessings of Liberty contains an important message about the origins and continuing relevance of religious liberty. Based on careful historical analysis of the development of religious liberty in England and the US, Witte demonstrates the importance of Protestant thinking both to the right and to human rights more generally. In the process he refutes both Christian and post-Enlightenment sceptics. His discussion of contemporary US and European law shows how much the right is still needed today, despite the claims of contemporary scholars that freedom of religion and belief is a redundant right.
- Published
- 2023
39. United Kingdom ∙ Competition, Big Tech and Retail Financial Services – A Regulator’s Discussion Paper
- Author
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K. Desai
- Subjects
Economics, Econometrics and Finance (miscellaneous) ,Law - Published
- 2023
40. Fuel pellets from fine paper mill sludge supplemented by sawdust and by refined recovered lubricating oil
- Author
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Chang-Yeong Lee, Isahq Ahmad, Ho-Kyung Goo, Jeong-Heon Ryu, Chul-Hwan Kim, and Min-Seok Lee
- Subjects
Environmental Engineering ,Mixing (process engineering) ,Pellets ,Bioengineering ,Proximate ,Pulp and paper industry ,Combustion ,law.invention ,Ignition system ,law ,visual_art ,visual_art.visual_art_medium ,Environmental science ,Fine paper ,Heat of combustion ,Sawdust ,Waste Management and Disposal - Abstract
Fine paper mill sludge (FPMS) disposal has emerged as a problem since the dumping of FPMS was banned. This study investigated the effects of adding a refined recovered lubricating oil (ion-refined oil) to FPMS pellets to increase its heating value and combustion time and decrease ash content and ignition time. Fuel pellets were prepared in three conditions, C-1, C-2, and C-3. In C-1, ion-refined oil was added to FPMS to examine its burning capability. In C-2, two types of pellets were produced mixing sawdust and FPMS ratios of 25:75 and 50:50. A ratio of 50:50 was selected for C-3, to which the ion-refined oil was added in different ratios. The quality of the energy fuel pellets was determined using proximate and ultimate analyses, except for chlorine content, which was determined through liquid ion chromatography. The properties of fuel pellets were determined and compared with national standards. It was confirmed that the results for pellets at a ratio of 50:50 with 10% and 15% ion-refined oil were acceptable, because these results were comparatively similar to the standards. Finally, it was concluded that ion-refined oil was an effective additive to FPMS to increase the heating value for energy demand and lower the ash content.
- Published
- 2020
41. Strong and tough graphene papers constructed with pyrene-containing small molecules via π-π/H-bonding synergistic interactions
- Author
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Shu-Hong Yu, Hong Yuan, Liangbing Ge, Jieyun Li, Na Shu, Tao Suo, Fang Xu, Kun Ni, Yanwu Zhu, Mengting Gao, Jianglin Ye, Fei Pan, Si-Ming Chen, and Xiukai Kan
- Subjects
Toughness ,Materials science ,Hydrogen bond ,Graphene ,Oxide ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,law.invention ,Micrometre ,chemistry.chemical_compound ,Chemical engineering ,chemistry ,law ,Molecule ,General Materials Science ,Density functional theory ,0210 nano-technology ,Graphene oxide paper - Abstract
Lightweight yet strong paper with high toughness is desirable especially for impact protection. Herein we demonstrated electrically conductive and mechanically robust paper (AP/PB-GP) made of reduced graphene oxide via interfacial crosslinking with 1-aminopyrene (AP) and 1-pyrenebutyrat (PB) small molecules. The AP/PB-GP with thickness of over ten micrometer delivers a record-high toughness (∼69.67 ± 15.3 MJ m−3 in average), simultaneously with superior strength (close to 1 GPa), allowing an impressive specific penetration energy absorption (∼0.17 MJ kg−1) at high impact velocities when used for ballistic impact protection. Detailed interfacial and structural analysis reveals that the reinforcement is synergistically determined by π-π interaction and H-bonding linkage between adjacent graphene lamellae. Especially, the defective pores within the graphene platelets benefit the favorable adsorption of the pyrene-containing molecules, which imperatively maximizes the interfacial binding, facilitating deflecting crack and plastic deformation under loading. Density functional theory simulation suggests that the coupling between the polar functional groups, e.g., −COOH, at the edges of graphene platelets and −NH2 and −COOH of AP/PB are critical to the formation of hydrogen bonding network.
- Published
- 2020
42. COMPARATIVE STUDY USING CALCIUM HYDROXIDE AND NANO CALCIUM HYDROXIDE TO DEACIDIFICATION OF ARCHAEOLOGICAL TRACING PAPER
- Author
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Amany Krorra, Wafika Noshy Wahba, and Marwa Abu Elleif
- Subjects
Materials science ,Calcium hydroxide ,Scanning electron microscope ,Isopropyl alcohol ,Accelerated aging ,Archaeology ,law.invention ,chemistry.chemical_compound ,chemistry ,Optical microscope ,Tracing paper ,law ,visual_art ,visual_art.visual_art_medium ,Hydroxide ,Fourier transform infrared spectroscopy - Abstract
The research aims to conduct an experimental study to compare the effect of the Deacidification of tracing paper using; Calcium Hydroxide dissolved in Ethyl alcohol; in comparison with that use Nanocalcium Hydroxide dissolved in Isopropyl alcohol. Then; performing tests and analysis to compare between the two materials, in order to select the most suitable one to deacidify archaeological tracing maps at the “Egyptian Geographical Society” in, Egypt. The treatment methods used on tracing paper samples have been assessed after accelerated aging procedures, to study the efficiency of the Deacidification materials, using FTIR analysis (Fourier transform infrared spectroscopy) to identify the chemical changes in the functional groups of cellulose, hemicelluloses and lignin, by comparing the intensity and regions of the absorption spectrum of their characteristic functional groups, in both the treated and standard samples. Also; microscopic examination was conducted; using Digital Light Microscope, and the Scanning Electron Microscope (SEM); to examine the surface appearance of the treated paper sample. Moreover; the visual properties by using a colorimeter to assess the colour changes that occurred in the treated paper samples before and aging. The mechanical properties of the paper samples were evaluated by measuring the tensile strength and elongation percentage. Furthermore; the quality of the Deacidification was evaluated by measuring the pH of the treated samples in comparison with the standard samples. The Nanocalcium Hydroxide treatment was proved to have a slight effect on the chemical composition of the paper and an improved Deacidification; in comparison to Calcium Hydroxide.
- Published
- 2020
43. A water-activated paper-based battery based on activated carbon powder anode and CuCl2/CNT cathode
- Author
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Yosuke Ito, Kozo Taguchi, and Dang Trang Nguyen
- Subjects
Battery (electricity) ,Nanotube ,Materials science ,020209 energy ,Activated carbon ,Proton exchange membrane fuel cell ,chemistry.chemical_element ,02 engineering and technology ,Carbon nanotube ,law.invention ,020401 chemical engineering ,Paper-based battery ,law ,Disposable ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,0204 chemical engineering ,Cathode ,Anode ,General Energy ,Chemical engineering ,chemistry ,Electrode ,Copper (II) chloride ,lcsh:Electrical engineering. Electronics. Nuclear engineering ,Carbon ,lcsh:TK1-9971 ,medicine.drug - Abstract
Water-activated paper-based batteries are expected to be low-cost disposable power sources for paper-based sensor applications. In this study, a disposable paper-based battery was developed. The battery used activated carbon powder loaded on a carbon sheet as the anode. The cathode was coated directly on a paper filter to fabricate an integrated proton exchange membrane cathode. Copper (II) chloride mixed with multiwalled carbon nanotube (CuCl2/CNT) was used as the cathode. Water was injected into the anode electrode to activate the battery. The maximum power density of 134. 6 μ W /cm2 was obtained with the anode loaded 17 mg cm−2 activated carbon powder. The power output of the battery is proportional to the amount of activated carbon loaded on the anode.
- Published
- 2020
44. A Colorimetric Distinct Color Change Cu(II) 4-{[1-(2,5-dihydroxyphenyl)ethylidene]amino}-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one Chemosensor and its Application as a Paper Test Kit
- Author
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Nilima Patil, Rajesh Dhake, Raju Phalak, Umesh Fegade, Chennan Ramalingan, Vadivel Saravanan, null Inamuddin, and Tariq Altalhi
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Clinical Psychology ,Sociology and Political Science ,Clinical Biochemistry ,Law ,Biochemistry ,Spectroscopy ,Social Sciences (miscellaneous) - Abstract
A “4-{[1-(2,5-dihydroxyphenyl)ethylidene]amino}-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one” chemosensor (C1) synthesized by Condensation reaction using “4-amino-1,2-dihydro-1,5-dimethyl-2-phenylpyrazol-3-one” and “2,5-dihydroxy Actophenone”. It shows absorption peak at 326 nm due to the C=C bond (π-π* transition), while the absorption peak at 364 nm is caused by the C=O bond (n-π* transition). In the presence of copper C1 only demonstrated a change in absorption peak to higher wavelength (redshift) from 364 to 425 nm. The hue of both the C1+Cu(II) complex changed from bright yellow to dark brown colour with hypochromic shift appearance of a new peak at 425 nm. Even in the presence of other competing metal ions, the hypsochromic shift of the absorption band and the quenching of the fluorescence emission intensity were different for detecting Cu2+, in CH3OH-H2O (v/v = 6:4). Job's plot was used to compute the binding stoichiometry between C1 and Cu2+, and MASS and FTIR spectrophotometry were used to investigate the complexation process. The capacity of the C1 to bind Cu2+ was further proven using DFT simulations. The complex S1+Cu2+ has a HOMO-LUMO energy gap of 2.8002 eV, which is lesser than S1 (2.9991 eV). From these results, it can be seen that the specific binding of S1 to Cu2+ improves the stability of the S1+Cu2+ complex and effectively reduces the HOMO-LUMO energy gap. The C1 was successfully used in a real-world water sample analysis. Using the Benesi-Hildebrand and Scatchard plots, the Kb was calculated and found to be 47340M-1 and 48369M-1 respectively, showing the creation of stable complexation between Cu2+ and S1 with 1:1 Stoichiometry. The LOD of S1 for Cu2+ ion analysis was determined to be 649 nM. Strip sheets were also built and tested to detect varying amounts of Cu2+ aqueous solution, and their color change suggested that they might be used for on-site Cu2+ detection in polluted water.
- Published
- 2022
45. The End of Law? Law, Theology, and Neuroscience. By David W. Opderbeck. Eugene: Cascade Books, 2021. Pp. 262. $46.00 (cloth); $31.00 (paper); $31.00 (digital). ISBN: 9781498223911
- Author
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Kevin P. Lee
- Subjects
Religious studies ,Law - Published
- 2022
46. Highly Conducting Nanographite-Filled Paper Fabricated via Standard Papermaking Techniques
- Author
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Hjalmar Granberg, Magnus Berggren, Emilie Calvie, Göran Gustafsson, Desalegn Alemu Mengistie, Xin Wang, Patrik Isacsson, Andreas Fall, and Isak Engquist
- Subjects
Materials science ,nanographite ,Materialkemi ,Nanotechnology ,02 engineering and technology ,Conductivity ,010402 general chemistry ,01 natural sciences ,electronic paper ,printed electronics ,electrochromic display ,graphene ,cellulose ,self-assembly ,law.invention ,law ,Materials Chemistry ,General Materials Science ,Fiber ,Electronic paper ,Graphene ,Papermaking ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Electrochromism ,Printed electronics ,Self-assembly ,0210 nano-technology ,Research Article - Abstract
Eco-friendly and cost-effective materials and processes to manufacture functional substrates are crucial to further advance the area of printed electronics. One potential key component in the printed electronics platform is an electrically functionalized paper, produced by simply mixing common cellulosic pulp fibers with high-performance electroactive materials. Herein, an electronic paper including nanographite has been prepared using a standardized and scalable papermaking technique. No retention aid was needed to achieve a conducting nanographite loading as high as 50 wt %. The spontaneous retention that provides the integrity and stability of the nanographite paper, likely originates partially from an observed water-stable adhesion of nanographite flakes onto the fiber surfaces. The resulting paper exhibits excellent electrical characteristics, such as an in-plane conductivity of 107 S/cm and an areal capacitance of 9.2 mF/cm(2), and was explored as the back-electrode in printed electrochromic displays. Funding Agencies|Digital Cellulose Centre, a competence center set up by the Swedish Innovation Agency VINNOVA; consortium of Swedish forest industries; Wallenberg Wood Science Center (Knut and Alice Wallenberg Foundation); VINNOVA "EPIC" projectVinnova [2017-05413]; Karl-Erik Onnesjo Foundation
- Published
- 2020
47. Simultaneously Detecting Monoamine Oxidase A and B in Disease Cell/Tissue Samples Using Paper-Based Devices
- Author
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Meirong Wu, Jie Liu, Changmin Yu, Xiao Huang, Wenhui Ji, Jinhua Liu, Lin Li, Hua Bai, Hai-Dong Yu, Ding Chen, Limin Wang, Qiong Wu, Bo Peng, Haixiao Fang, Yipei Chen, and Naidi Yang
- Subjects
Paper ,Cell ,Biomedical Engineering ,Mitochondrion ,law.invention ,Cell Line ,Biomaterials ,law ,Neoplasms ,medicine ,Humans ,Monoamine Oxidase ,Chemiluminescence ,chemistry.chemical_classification ,biology ,Chemistry ,fungi ,Biochemistry (medical) ,food and beverages ,Oxidative deamination ,General Chemistry ,Monoamine neurotransmitter ,medicine.anatomical_structure ,Enzyme ,Biochemistry ,Equipment and Supplies ,biology.protein ,Monoamine oxidase A ,Bacterial outer membrane - Abstract
As enzymes in the outer membrane of the mitochondrion, monoamine oxidases (MAOs) can catalyze the oxidative deamination of monoamines in the human body. According to different substrates, MAOs can be divided into MAO-A and MAO-B. The imbalance of the MAO-A is associated with neurological degeneration, while excess MAO-B activity is closely connected with Parkinson's disease (PD) and Alzheimer's disease (AD); therefore, detection of MAOs is of great significance for the diagnosis and treatment of these diseases. This work reports the multiplexed detection of MAO-A and MAO-B using paper-based devices based on chemiluminescence (CL). The detection limits were 5.01 pg/mL for MAO-A and 8.50 pg/mL for MAO-B in human serum. In addition, we used paper-based devices to detect MAOs in human cells and tissue samples and found that the results of paper-based detection and Western blotting (WB) showed the same trend. While only one antibody can be incubated on the same membrane by WB, multiple antibodies incubated on the same paper enabled simultaneous detection of MAO-A and MAO-B by paper-based devices. The paper-based assay could be used for preliminary early screening of clinical samples for MAOs and can be extended as an alternative to WB for multiplexed detection of various proteins in disease cell or tissue samples.
- Published
- 2022
48. An Analysis on the Characteristics of the Items in Paper Based Test (PBT) and Smart Device Based Test (SBT) - Focused on the Optician National Board Examination
- Author
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Eun Joo Kim and Jung Un Jang
- Subjects
law ,Computer science ,Smart device ,Paper based ,Simulation ,Test (assessment) ,law.invention - Published
- 2021
49. Simple Approach for Building High Transconductance Paper-Based Organic Electrochemical Transistor (OECT) for Chemical Sensing
- Author
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Adil Ait Yazza, Francisco J. Andrade, and Pascal Blondeau
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Materials science ,business.industry ,Transconductance ,Transistor ,Glucose detection ,Paper based ,Electrochemistry ,Electronic, Optical and Magnetic Materials ,law.invention ,law ,Simple (abstract algebra) ,Materials Chemistry ,Optoelectronics ,business ,Organic electrochemical transistor - Abstract
Organic electrochemical transistors (OECTs) have attracted great interest in the last few years as biochemical sensors due to their outstanding analytical performance, versatility, stability, and e...
- Published
- 2021
50. Mobile Diary App Versus Paper-Based Diary Cards for Patients With Borderline Personality Disorder:Economic Evaluation
- Author
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Lars Holger Ehlers, Sabrina Storgaard Sørensen, Stig Helweg-Jørgensen, Sidsel Lund Laursen, Mia Beck Lichtenstein, Kim Mathiasen, Astrid Langergaard, and Jesper Søndergaard
- Subjects
medicine.medical_specialty ,Health Economic Evaluation ,dialectical behavior therapy ,Borderline Personality Disorder/diagnosis ,Cost-Benefit Analysis ,medicine.medical_treatment ,Health Informatics ,Anxiety ,Suicidal Ideation ,law.invention ,Randomized controlled trial ,Borderline Personality Disorder ,law ,mobile app ,Health care ,medicine ,Humans ,Psychiatry ,mHealth ,Borderline personality disorder ,Depression (differential diagnoses) ,Original Paper ,mobile phone ,business.industry ,medicine.disease ,Mobile Applications ,Focus group ,Dialectical behavior therapy ,psychotherapy ,cost-consequence ,Economic evaluation ,business ,borderline personality disorder - Abstract
Background: The cost-effectiveness of using a mobile diary app as an adjunct in dialectical behavior therapy (DBT) in patientswith borderline personality disorder is unknown.Objective: This study aims to perform an economic evaluation of a mobile diary app compared with paper-based diary cardsin DBT treatment for patients with borderline personality disorder in a psychiatric outpatient facility.Methods: This study was conducted alongside a pragmatic, multicenter, randomized controlled trial. The participants wererecruited at 5 Danish psychiatric outpatient facilities and were randomized to register the emotions, urges, and skills used in amobile diary app or on paper-based diary cards. The participants in both groups received DBT delivered by the therapists. Acost-consequence analysis with a time horizon of 12 months was performed. Consequences included quality-adjusted life years(QALYs), depression severity, borderline severity, suicidal behavior, health care use, treatment compliance, and system usability.All relevant costs were included. Focus group interviews were conducted with patients, therapists, researchers, and industryrepresentatives to discuss the potential advantages and disadvantages of using a mobile diary app.Results: A total of 78 participants were included in the analysis. An insignificantly higher number of participants in the papergroup dropped out before the start of treatment (P=.07). Of those starting treatment, participants in the app group had an averageof 37.1 (SE 27.55) more days of treatment and recorded an average of 3.16 (SE 5.10) more skills per week than participants inthe paper group. Participants in both groups had a QALY gain and a decrease in depression severity, borderline severity, andsuicidal behavior. Significant differences were found in favor of the paper group for both QALY gain (adjusted difference −0.054;SE 0.03) and reduction in depression severity (adjusted difference −1.11; SE 1.57). The between-group difference in total costsranged from US $107.37 to US $322.10 per participant during the 12 months. The use of services in the health care sector wassimilar across both time points and groups (difference: psychiatric hospitalization and 2.02; SE 3.19). Overall, the patients showed high acceptability and considered the app as being easy to use. Therapists worriedabout potential negative influences on the therapist-patient interaction from new work tasks accompanying the introduction ofthe new technology but pointed at innovation potential from digital database registrations.Conclusions: This study suggests both positive and negative consequences of mobile diary apps as adjuncts to DBT comparedwith paper diary cards. More research is needed to draw conclusions regarding its cost-effectiveness. Background:The cost-effectiveness of using a mobile diary app as an adjunct in dialectical behavior therapy (DBT) in patients with borderline personality disorder is unknown.Objective:This study aims to perform an economic evaluation of a mobile diary app compared with paper-based diary cards in DBT treatment for patients with borderline personality disorder in a psychiatric outpatient facility.Methods:This study was conducted alongside a pragmatic, multicenter, randomized controlled trial. The participants were recruited at 5 Danish psychiatric outpatient facilities and were randomized to register the emotions, urges, and skills used in a mobile diary app or on paper-based diary cards. The participants in both groups received DBT delivered by the therapists. A cost-consequence analysis with a time horizon of 12 months was performed. Consequences included quality-adjusted life years (QALYs), depression severity, borderline severity, suicidal behavior, health care use, treatment compliance, and system usability. All relevant costs were included. Focus group interviews were conducted with patients, therapists, researchers, and industry representatives to discuss the potential advantages and disadvantages of using a mobile diary app.Results:A total of 78 participants were included in the analysis. An insignificantly higher number of participants in the paper group dropped out before the start of treatment (P=.07). Of those starting treatment, participants in the app group had an average of 37.1 (SE 27.55) more days of treatment and recorded an average of 3.16 (SE 5.10) more skills per week than participants in the paper group. Participants in both groups had a QALY gain and a decrease in depression severity, borderline severity, and suicidal behavior. Significant differences were found in favor of the paper group for both QALY gain (adjusted difference −0.054; SE 0.03) and reduction in depression severity (adjusted difference −1.11; SE 1.57). The between-group difference in total costs ranged from US $107.37 to US $322.10 per participant during the 12 months. The use of services in the health care sector was similar across both time points and groups (difference: psychiatric hospitalization Conclusions:This study suggests both positive and negative consequences of mobile diary apps as adjuncts to DBT compared with paper diary cards. More research is needed to draw conclusions regarding its cost-effectiveness.
- Published
- 2021
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