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1. Long-term follow-up of children exposed in-utero to progesterone treatment for prevention of preterm birth: study protocol of the AMPHIA follow-up

Author

Leerstoel Baar, Development and Treatment of Psychosocial Problems, Leerstoel Bogt, Simons, Noor E, Van Limburg Stirum, Emilie V J, Van Wassenaer-leemhuis, Aleid G, Finken, Martijn J J, Aarnoudse-moens, Cornelieke S H, Oosterlaan, Jaap, Van Baar, Anneloes, Roseboom, Tessa J, Lim, Arianne C, Van Wely, Madelon, De Boer, Marjon A, Painter, Rebecca C, Pajkrt, Eva, Oudijk, Martijn A, Van T Hooft, Janneke, Leerstoel Baar, Development and Treatment of Psychosocial Problems, Leerstoel Bogt, Simons, Noor E, Van Limburg Stirum, Emilie V J, Van Wassenaer-leemhuis, Aleid G, Finken, Martijn J J, Aarnoudse-moens, Cornelieke S H, Oosterlaan, Jaap, Van Baar, Anneloes, Roseboom, Tessa J, Lim, Arianne C, Van Wely, Madelon, De Boer, Marjon A, Painter, Rebecca C, Pajkrt, Eva, Oudijk, Martijn A, and Van T Hooft, Janneke

Published
2021

2. Long-term follow-up of children exposed in-utero to progesterone treatment for prevention of preterm birth: study protocol of the AMPHIA follow-up

Author

Leerstoel Baar, Development and Treatment of Psychosocial Problems, Leerstoel Bogt, Simons, Noor E, Van Limburg Stirum, Emilie V J, Van Wassenaer-leemhuis, Aleid G, Finken, Martijn J J, Aarnoudse-moens, Cornelieke S H, Oosterlaan, Jaap, Van Baar, Anneloes, Roseboom, Tessa J, Lim, Arianne C, Van Wely, Madelon, De Boer, Marjon A, Painter, Rebecca C, Pajkrt, Eva, Oudijk, Martijn A, Van T Hooft, Janneke, Leerstoel Baar, Development and Treatment of Psychosocial Problems, Leerstoel Bogt, Simons, Noor E, Van Limburg Stirum, Emilie V J, Van Wassenaer-leemhuis, Aleid G, Finken, Martijn J J, Aarnoudse-moens, Cornelieke S H, Oosterlaan, Jaap, Van Baar, Anneloes, Roseboom, Tessa J, Lim, Arianne C, Van Wely, Madelon, De Boer, Marjon A, Painter, Rebecca C, Pajkrt, Eva, Oudijk, Martijn A, and Van T Hooft, Janneke

Published
2021

3. Long-term follow-up of children exposed in-utero to progesterone treatment for prevention of preterm birth: study protocol of the AMPHIA follow-up

Author

Leerstoel Baar, Development and Treatment of Psychosocial Problems, Leerstoel Bogt, Simons, Noor E, Van Limburg Stirum, Emilie V J, Van Wassenaer-leemhuis, Aleid G, Finken, Martijn J J, Aarnoudse-moens, Cornelieke S H, Oosterlaan, Jaap, Van Baar, Anneloes, Roseboom, Tessa J, Lim, Arianne C, Van Wely, Madelon, De Boer, Marjon A, Painter, Rebecca C, Pajkrt, Eva, Oudijk, Martijn A, Van T Hooft, Janneke, Leerstoel Baar, Development and Treatment of Psychosocial Problems, Leerstoel Bogt, Simons, Noor E, Van Limburg Stirum, Emilie V J, Van Wassenaer-leemhuis, Aleid G, Finken, Martijn J J, Aarnoudse-moens, Cornelieke S H, Oosterlaan, Jaap, Van Baar, Anneloes, Roseboom, Tessa J, Lim, Arianne C, Van Wely, Madelon, De Boer, Marjon A, Painter, Rebecca C, Pajkrt, Eva, Oudijk, Martijn A, and Van T Hooft, Janneke

Published
2021

4. Temporizing management vs immediate delivery in early-onset severe preeclampsia between 28 and 34 weeks of gestation (TOTEM study): An open-label randomized controlled trial

Author

Duvekot, J.J., Duijnhoven, RG, van Horen, E, Bax, CJ, Bloemenkamp, KW, Brussé, Ingrid, Dijk, PH, Franssen, MT, Franx, A (Arie), Oudijk, MA, Porath, MM, Scheepers, HCJ, van Wassenaer-Leemhuis, AG, van Drongelen, J, Mol, BW, Ganzevoort, W, Duvekot, J.J., Duijnhoven, RG, van Horen, E, Bax, CJ, Bloemenkamp, KW, Brussé, Ingrid, Dijk, PH, Franssen, MT, Franx, A (Arie), Oudijk, MA, Porath, MM, Scheepers, HCJ, van Wassenaer-Leemhuis, AG, van Drongelen, J, Mol, BW, and Ganzevoort, W

Abstract

Introduction: There is little evidence to guide the timing of delivery of women with early-onset severe preeclampsia. We hypothesize that immediate delivery is not inferior for neonatal outcome but reduces maternal complications compared with temporizing management. Material and methods: This Dutch multicenter open-label randomized clinical trial investigated non-inferiority for neonatal outcome of temporizing management as compared with immediate delivery (TOTEM NTR 2986) in women between 27+5 and 33+5 weeks of gestation admitted for early-onset severe preeclampsia with or without HELLP syndrome. In participants allocated to receive immediate delivery, either induction of labor or cesarean section was initiated at least 48 hours after admission. Primary outcomes were adverse perinatal outcome, defined as a composite of severe respiratory distress syndrome, bronchopulmonary dysplasia, culture proven sepsis, intraventricular hemorrhage grade 3 or worse, periventricular leukomalacia grade 2 or worse, necrotizing enterocolitis stage 2 or worse, and perinatal death. Major maternal complications were secondary outcomes. It was estimated 1130 women needed to be enrolled. Analysis was by intention-to-treat. Results: The trial was halted after 35 months because of slow recruitment. Between February 2011 and December 2013, a total of 56 women were randomized to immediate delivery (n = 26) or temporizing management (n = 30). Median gestational age at randomization was 30 weeks. Median prolongation of pregnancy was 2 days (interquartile range 1-3 days) in the temporizing management group. Mean birthweight was 1435 g after immediate delivery vs 1294 g after temporizing management (P =.14). The adverse perinatal outcome rate was 55% in the immediate delivery group vs 52% in the temporizing management group (relative risk 1.06; 95% confidence interval 0.67-1.70). In both groups there was one neonatal death and no maternal deaths. In the temporizing treatm

Published
2021

5. Maternal Sildenafil vs Placebo in Pregnant Women With Severe Early-Onset Fetal Growth Restriction A Randomized Clinical Trial

Author

Pels, A, Derks, J, Elvan-Taspinar, A, van Drongelen, J, Boer, M, Duvekot, J.J., van Laar, JAM, Eyck, J, Al-Nasiry, S, Sueters, M, Verhoef-Post, M, Onland, W, van Wassenaer-Leemhuis, A, Naaktgeboren, C, Jakobsen, JC, Gluud, C, Duijnhoven, RG, Lely, T, Gordijn, S, Ganzevoort, W, Pels, A, Derks, J, Elvan-Taspinar, A, van Drongelen, J, Boer, M, Duvekot, J.J., van Laar, JAM, Eyck, J, Al-Nasiry, S, Sueters, M, Verhoef-Post, M, Onland, W, van Wassenaer-Leemhuis, A, Naaktgeboren, C, Jakobsen, JC, Gluud, C, Duijnhoven, RG, Lely, T, Gordijn, S, and Ganzevoort, W

Published
2020

6. Maternal sildenafil vs placebo in pregnant women with severe early-onset fetal growth restriction: A randomized clinical trial

Author

MS Verloskunde, Other research (not in main researchprogram), Child Health, Circulatory Health, Pels, Anouk, Derks, Jan, Elvan-Taspinar, Ayten, Van Drongelen, Joris, De Boer, Marjon, Duvekot, Hans, Van Laar, Judith, Van Eyck, Jim, Al-Nasiry, Salwan, Sueters, Marieke, Post, Marinka, Onland, Wes, Van Wassenaer-Leemhuis, Aleid, Naaktgeboren, Christiana, Jakobsen, Janus C., Gluud, Christian, Duijnhoven, Ruben G., Lely, Titia, Gordijn, Sanne, Ganzevoort, Wessel, MS Verloskunde, Other research (not in main researchprogram), Child Health, Circulatory Health, Pels, Anouk, Derks, Jan, Elvan-Taspinar, Ayten, Van Drongelen, Joris, De Boer, Marjon, Duvekot, Hans, Van Laar, Judith, Van Eyck, Jim, Al-Nasiry, Salwan, Sueters, Marieke, Post, Marinka, Onland, Wes, Van Wassenaer-Leemhuis, Aleid, Naaktgeboren, Christiana, Jakobsen, Janus C., Gluud, Christian, Duijnhoven, Ruben G., Lely, Titia, Gordijn, Sanne, and Ganzevoort, Wessel

Published
2020

7. Amnioinfusion Compared With No Intervention in Women With Second-Trimester Rupture of Membranes : A Randomized Controlled Trial

Author

van Kempen, Liselotte E M, van Teeffelen, Augustinus S, de Ruigh, Annemijn A, Oepkes, Dick, Haak, Monique C, van Leeuwen, Elisabeth, Woiski, Mallory, Porath, Martina M, Bax, Caroline J, van Wassenaer-Leemhuis, Aleid G, Mulder, Antonius L, van der Ham, David P, Willekes, Christine, Franssen, Maureen T, Derks, Jan B, Schuit, Ewoud, Mol, Ben W, Pajkrt, Eva, van Kempen, Liselotte E M, van Teeffelen, Augustinus S, de Ruigh, Annemijn A, Oepkes, Dick, Haak, Monique C, van Leeuwen, Elisabeth, Woiski, Mallory, Porath, Martina M, Bax, Caroline J, van Wassenaer-Leemhuis, Aleid G, Mulder, Antonius L, van der Ham, David P, Willekes, Christine, Franssen, Maureen T, Derks, Jan B, Schuit, Ewoud, Mol, Ben W, and Pajkrt, Eva

Published
2019

8. Child outcomes after placement of a cervical pessary in women with a multiple pregnancy: A 4-year follow-up of the ProTWIN trial

Author

Simons, Noor E., van de Beek, Cornelieke, van der Lee, Johanna H., Opmeer, Brent C., van Wassenaer-Leemhuis, Aleid G., van Baar, Anneloes L., Steenis, Leonie, Liem, Sophie, Schuit, Ewoud, Bekedam, Dick, Mol, Ben W. J., van't Hooft, Janneke, Simons, Noor E., van de Beek, Cornelieke, van der Lee, Johanna H., Opmeer, Brent C., van Wassenaer-Leemhuis, Aleid G., van Baar, Anneloes L., Steenis, Leonie, Liem, Sophie, Schuit, Ewoud, Bekedam, Dick, Mol, Ben W. J., and van't Hooft, Janneke

Published
2019

9. Detailed statistical analysis plan for the Dutch STRIDER (Sildenafil TheRapy In Dismal prognosis Early-onset fetal growth Restriction) randomised clinical trial on sildenafil versus placebo for pregnant women with severe early onset fetal growth restriction

Author

Pels, Anouk, Jakobsen, Janus C., Ganzevoort, Wessel, Naaktgeboren, Christiana A., Onland, Wes, van Wassenaer-Leemhuis, Aleid G., Gluud, Christian, Pels, Anouk, Jakobsen, Janus C., Ganzevoort, Wessel, Naaktgeboren, Christiana A., Onland, Wes, van Wassenaer-Leemhuis, Aleid G., and Gluud, Christian

Published
2019

10. Child outcomes after placement of a cervical pessary in women with a multiple pregnancy: A 4-year follow-up of the ProTWIN trial

Author

Simons, Noor E., van de Beek, Cornelieke, van der Lee, Johanna H., Opmeer, Brent C., van Wassenaer-Leemhuis, Aleid G., van Baar, Anneloes L., Steenis, Leonie, Liem, Sophie, Schuit, Ewoud, Bekedam, Dick, Mol, Ben W. J., van't Hooft, Janneke, Simons, Noor E., van de Beek, Cornelieke, van der Lee, Johanna H., Opmeer, Brent C., van Wassenaer-Leemhuis, Aleid G., van Baar, Anneloes L., Steenis, Leonie, Liem, Sophie, Schuit, Ewoud, Bekedam, Dick, Mol, Ben W. J., and van't Hooft, Janneke

Published
2019

11. Amnioinfusion Compared With No Intervention in Women With Second-Trimester Rupture of Membranes : A Randomized Controlled Trial

Author

van Kempen, Liselotte E M, van Teeffelen, Augustinus S, de Ruigh, Annemijn A, Oepkes, Dick, Haak, Monique C, van Leeuwen, Elisabeth, Woiski, Mallory, Porath, Martina M, Bax, Caroline J, van Wassenaer-Leemhuis, Aleid G, Mulder, Antonius L, van der Ham, David P, Willekes, Christine, Franssen, Maureen T, Derks, Jan B, Schuit, Ewoud, Mol, Ben W, Pajkrt, Eva, van Kempen, Liselotte E M, van Teeffelen, Augustinus S, de Ruigh, Annemijn A, Oepkes, Dick, Haak, Monique C, van Leeuwen, Elisabeth, Woiski, Mallory, Porath, Martina M, Bax, Caroline J, van Wassenaer-Leemhuis, Aleid G, Mulder, Antonius L, van der Ham, David P, Willekes, Christine, Franssen, Maureen T, Derks, Jan B, Schuit, Ewoud, Mol, Ben W, and Pajkrt, Eva

Published
2019

12. Detailed statistical analysis plan for the Dutch STRIDER (Sildenafil TheRapy In Dismal prognosis Early-onset fetal growth Restriction) randomised clinical trial on sildenafil versus placebo for pregnant women with severe early onset fetal growth restriction

Author

Pels, Anouk, Jakobsen, Janus C., Ganzevoort, Wessel, Naaktgeboren, Christiana A., Onland, Wes, van Wassenaer-Leemhuis, Aleid G., Gluud, Christian, Pels, Anouk, Jakobsen, Janus C., Ganzevoort, Wessel, Naaktgeboren, Christiana A., Onland, Wes, van Wassenaer-Leemhuis, Aleid G., and Gluud, Christian

Published
2019

13. Amnioinfusion Compared With No Intervention in Women With Second-Trimester Rupture of Membranes : A Randomized Controlled Trial

Author

van Kempen, Liselotte E M, van Teeffelen, Augustinus S, de Ruigh, Annemijn A, Oepkes, Dick, Haak, Monique C, van Leeuwen, Elisabeth, Woiski, Mallory, Porath, Martina M, Bax, Caroline J, van Wassenaer-Leemhuis, Aleid G, Mulder, Antonius L, van der Ham, David P, Willekes, Christine, Franssen, Maureen T, Derks, Jan B, Schuit, Ewoud, Mol, Ben W, Pajkrt, Eva, van Kempen, Liselotte E M, van Teeffelen, Augustinus S, de Ruigh, Annemijn A, Oepkes, Dick, Haak, Monique C, van Leeuwen, Elisabeth, Woiski, Mallory, Porath, Martina M, Bax, Caroline J, van Wassenaer-Leemhuis, Aleid G, Mulder, Antonius L, van der Ham, David P, Willekes, Christine, Franssen, Maureen T, Derks, Jan B, Schuit, Ewoud, Mol, Ben W, and Pajkrt, Eva

Published
2019

14. Child outcomes after placement of a cervical pessary in women with a multiple pregnancy: A 4-year follow-up of the ProTWIN trial

Author

Simons, Noor E., van de Beek, Cornelieke, van der Lee, Johanna H., Opmeer, Brent C., van Wassenaer-Leemhuis, Aleid G., van Baar, Anneloes L., Steenis, Leonie, Liem, Sophie, Schuit, Ewoud, Bekedam, Dick, Mol, Ben W. J., van't Hooft, Janneke, Simons, Noor E., van de Beek, Cornelieke, van der Lee, Johanna H., Opmeer, Brent C., van Wassenaer-Leemhuis, Aleid G., van Baar, Anneloes L., Steenis, Leonie, Liem, Sophie, Schuit, Ewoud, Bekedam, Dick, Mol, Ben W. J., and van't Hooft, Janneke

Published
2019

15. Detailed statistical analysis plan for the Dutch STRIDER (Sildenafil TheRapy In Dismal prognosis Early-onset fetal growth Restriction) randomised clinical trial on sildenafil versus placebo for pregnant women with severe early onset fetal growth restriction

Author

Pels, Anouk, Jakobsen, Janus C., Ganzevoort, Wessel, Naaktgeboren, Christiana A., Onland, Wes, van Wassenaer-Leemhuis, Aleid G., Gluud, Christian, Pels, Anouk, Jakobsen, Janus C., Ganzevoort, Wessel, Naaktgeboren, Christiana A., Onland, Wes, van Wassenaer-Leemhuis, Aleid G., and Gluud, Christian

Published
2019

16. Developmental outcomes of very preterm children with high parental education level

Author

van Houdt, Carolien A., van Wassenaer-Leemhuis, Aleid G., Oosterlaan, Jaap, van Kaam, Anton H., Aarnoudse-Moens, Cornelieke S.H., van Houdt, Carolien A., van Wassenaer-Leemhuis, Aleid G., Oosterlaan, Jaap, van Kaam, Anton H., and Aarnoudse-Moens, Cornelieke S.H.

Abstract

Background: Compared to their term-born peers, children born very preterm are at risk for poorer cognitive, academic and behavioral outcomes, however this finding may have been confounded by lower parental education level in the very preterm children. Studies that compare very preterm and term-born children with comparable (high)parental education level are needed to assess the true effect of very preterm birth on outcomes. Aims: To compare cognitive, academic and behavioral functioning in very preterm and term-born children of highly educated parents. To examine whether outcomes differ for children of whom one or both parents are highly educated. Study design: Cross-sectional study with a term-born comparison group. Subjects: 113 very preterm children and 38 term-born children aged 8–12 years old, with highly educated parents. Measures: Cognitive functioning (Intelligence Quotient), academic functioning (arithmetic facts and reading)and parent and teacher rated behavioral functioning (attention, executive function, hyperactivity, and emotional, conduct and peer problems). Parental education was considered high when children had two highly educated parents or one highly- and one middle educated parent. Results: Very preterm children had significantly poorer cognitive (difference of 10 IQ points)and behavioral functioning than their term-born peers, but did not differ on academic functioning. Children with one highly educated parent performed poorer than children with two highly educated parents on most outcome measures. Conclusions: Performance of very preterm children should be compared to term-born peers with parents having comparable educational levels for accurate assessment of outcomes. The number of highly educated parents also impacts outcomes.

Published
2019
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17. Child outcomes after placement of a cervical pessary in women with a multiple pregnancy: A 4-year follow-up of the ProTWIN trial

Author

Epi Methoden Team 4, JC onderzoeksprogramma Methodologie, Simons, Noor E., van de Beek, Cornelieke, van der Lee, Johanna H., Opmeer, Brent C., van Wassenaer-Leemhuis, Aleid G., van Baar, Anneloes L., Steenis, Leonie, Liem, Sophie, Schuit, Ewoud, Bekedam, Dick, Mol, Ben W. J., van't Hooft, Janneke, Epi Methoden Team 4, JC onderzoeksprogramma Methodologie, Simons, Noor E., van de Beek, Cornelieke, van der Lee, Johanna H., Opmeer, Brent C., van Wassenaer-Leemhuis, Aleid G., van Baar, Anneloes L., Steenis, Leonie, Liem, Sophie, Schuit, Ewoud, Bekedam, Dick, Mol, Ben W. J., and van't Hooft, Janneke

Published
2019

18. Amnioinfusion Compared With No Intervention in Women With Second-Trimester Rupture of Membranes: A Randomized Controlled Trial

Author

MS Verloskunde, Other research (not in main researchprogram), Epi Methoden Team 4, JC onderzoeksprogramma Methodologie, van Kempen, Liselotte E M, van Teeffelen, Augustinus S, de Ruigh, Annemijn A, Oepkes, Dick, Haak, Monique C, van Leeuwen, Elisabeth, Woiski, Mallory, Porath, Martina M, Bax, Caroline J, van Wassenaer-Leemhuis, Aleid G, Mulder, Antonius L, van der Ham, David P, Willekes, Christine, Franssen, Maureen T, Derks, Jan B, Schuit, Ewoud, Mol, Ben W, Pajkrt, Eva, MS Verloskunde, Other research (not in main researchprogram), Epi Methoden Team 4, JC onderzoeksprogramma Methodologie, van Kempen, Liselotte E M, van Teeffelen, Augustinus S, de Ruigh, Annemijn A, Oepkes, Dick, Haak, Monique C, van Leeuwen, Elisabeth, Woiski, Mallory, Porath, Martina M, Bax, Caroline J, van Wassenaer-Leemhuis, Aleid G, Mulder, Antonius L, van der Ham, David P, Willekes, Christine, Franssen, Maureen T, Derks, Jan B, Schuit, Ewoud, Mol, Ben W, and Pajkrt, Eva

Published
2019

19. Detailed statistical analysis plan for the Dutch STRIDER (Sildenafil TheRapy In Dismal prognosis Early-onset fetal growth Restriction) randomised clinical trial on sildenafil versus placebo for pregnant women with severe early onset fetal growth restriction

Author

Epi Methoden Team 1, JC onderzoeksprogramma Methodologie, Pels, Anouk, Jakobsen, Janus C., Ganzevoort, Wessel, Naaktgeboren, Christiana A., Onland, Wes, van Wassenaer-Leemhuis, Aleid G., Gluud, Christian, Epi Methoden Team 1, JC onderzoeksprogramma Methodologie, Pels, Anouk, Jakobsen, Janus C., Ganzevoort, Wessel, Naaktgeboren, Christiana A., Onland, Wes, van Wassenaer-Leemhuis, Aleid G., and Gluud, Christian

Published
2019

20. Neurodevelopmental outcomes at five years after early-onset fetal growth restriction: Analyses in a Dutch subgroup participating in a European management trial

Author

Kinderbewegingszorg patientenzorg, Brain, MS Neonatologie, UMC Utrecht, MS Verloskunde, Other research (not in main researchprogram), Pels, A., Knaven, O. C., Wijnberg-Williams, B. J., Eijsermans, M. J.C., Mulder-de Tollenaer, S. M., Aarnoudse-Moens, C. S.H., Koopman-Esseboom, C., van Eyck, J., Derks, J. B., Ganzevoort, W., van Wassenaer-Leemhuis, A. G., Kinderbewegingszorg patientenzorg, Brain, MS Neonatologie, UMC Utrecht, MS Verloskunde, Other research (not in main researchprogram), Pels, A., Knaven, O. C., Wijnberg-Williams, B. J., Eijsermans, M. J.C., Mulder-de Tollenaer, S. M., Aarnoudse-Moens, C. S.H., Koopman-Esseboom, C., van Eyck, J., Derks, J. B., Ganzevoort, W., and van Wassenaer-Leemhuis, A. G.

Published
2019

21. Pessary for preterm birth prevention in twin pregnancy with short cervix : 3-year follow-up study

Author

van 't Hooft, Janneke, van der Lee, Johanna H, Opmeer, Brent C, van Wassenaer-Leemhuis, Aleid G, van Baar, Anneloes L, Bekedam, Dick J, Steenis, Leonie J P, Liem, Sophie, Schuit, Ewoud, Cuijpers, Cuny, Bleeker, Elise, Vinke, Margot E, Simons, Noor, de Graaf, Irene M, Mol, Ben Willem J, van de Beek, Cornelieke, van 't Hooft, Janneke, van der Lee, Johanna H, Opmeer, Brent C, van Wassenaer-Leemhuis, Aleid G, van Baar, Anneloes L, Bekedam, Dick J, Steenis, Leonie J P, Liem, Sophie, Schuit, Ewoud, Cuijpers, Cuny, Bleeker, Elise, Vinke, Margot E, Simons, Noor, de Graaf, Irene M, Mol, Ben Willem J, and van de Beek, Cornelieke

Published
2018

22. Pessary for preterm birth prevention in twin pregnancy with short cervix : 3-year follow-up study

Author

van 't Hooft, Janneke, van der Lee, Johanna H, Opmeer, Brent C, van Wassenaer-Leemhuis, Aleid G, van Baar, Anneloes L, Bekedam, Dick J, Steenis, Leonie J P, Liem, Sophie, Schuit, Ewoud, Cuijpers, Cuny, Bleeker, Elise, Vinke, Margot E, Simons, Noor, de Graaf, Irene M, Mol, Ben Willem J, van de Beek, Cornelieke, van 't Hooft, Janneke, van der Lee, Johanna H, Opmeer, Brent C, van Wassenaer-Leemhuis, Aleid G, van Baar, Anneloes L, Bekedam, Dick J, Steenis, Leonie J P, Liem, Sophie, Schuit, Ewoud, Cuijpers, Cuny, Bleeker, Elise, Vinke, Margot E, Simons, Noor, de Graaf, Irene M, Mol, Ben Willem J, and van de Beek, Cornelieke

Published
2018

23. Pessary for preterm birth prevention in twin pregnancy with short cervix : 3-year follow-up study

Author

van 't Hooft, Janneke, van der Lee, Johanna H, Opmeer, Brent C, van Wassenaer-Leemhuis, Aleid G, van Baar, Anneloes L, Bekedam, Dick J, Steenis, Leonie J P, Liem, Sophie, Schuit, Ewoud, Cuijpers, Cuny, Bleeker, Elise, Vinke, Margot E, Simons, Noor, de Graaf, Irene M, Mol, Ben Willem J, van de Beek, Cornelieke, van 't Hooft, Janneke, van der Lee, Johanna H, Opmeer, Brent C, van Wassenaer-Leemhuis, Aleid G, van Baar, Anneloes L, Bekedam, Dick J, Steenis, Leonie J P, Liem, Sophie, Schuit, Ewoud, Cuijpers, Cuny, Bleeker, Elise, Vinke, Margot E, Simons, Noor, de Graaf, Irene M, Mol, Ben Willem J, and van de Beek, Cornelieke

Published
2018

24. Long-term effects of oral antidiabetic drugs during pregnancy on offspring:a systematic review and meta-analysis of follow-up studies of RCTs

Author

van Weelden, W. (Wenneke), Wekker, V. (Vincent), de Wit, L. (Leon), Limpens, J. (Jacqueline), Ijäs, H. (Hilkka), van Wassenaer-Leemhuis, A. G. (Aleid G.), Roseboom, T. J. (Tessa J.), van Rijn, B. B. (Bas B.), DeVries, J. H. (J. Hans), Painter, R. C. (Rebecca C.), van Weelden, W. (Wenneke), Wekker, V. (Vincent), de Wit, L. (Leon), Limpens, J. (Jacqueline), Ijäs, H. (Hilkka), van Wassenaer-Leemhuis, A. G. (Aleid G.), Roseboom, T. J. (Tessa J.), van Rijn, B. B. (Bas B.), DeVries, J. H. (J. Hans), and Painter, R. C. (Rebecca C.)

Abstract

Introduction: Antidiabetic drugs (OADs) are increasingly prescribed to treat hyperglycaemia during pregnancy in women with gestational diabetes mellitus (GDM) or polycystic ovary syndrome (PCOS), even though long-term effects on offspring are unknown. This systematic review summarises the evidence of follow-up studies of randomised controlled trials (RCTs) reporting on long-term effects of prenatal exposure to OADs on offspring. Methods: The MEDLINE, EMBASE and CENTRAL databases were searched from inception to April 2018 for the concepts antidiabetic agents and prenatal exposure (or pregnancy and offspring/child) in combination with an RCT search filter. RCTs evaluating post-neonatal health effects in offspring and comparing maternal treatment with an OAD with no treatment, placebo, an alternative OAD or insulin during pregnancy were eligible for inclusion. Two independent researchers selected, extracted and assessed the data. Meta-analyses were performed using a random effects model and the Cochrane Collaboration’s risk of bias tool was used for quality assessment. Results: Ten studies were included, with a maximal follow-up duration of 9 years, comprising 778 children of mothers with GDM or PCOS who were randomised to either metformin or insulin/placebo during pregnancy. Meta-analysis showed that children prenatally exposed to metformin were heavier compared to controls (standardised mean difference (SMD) 0.26 [95% CI 0.11–0.41]), but not taller (SMD 0.10 [95% CI −0.14–0.33]). Additionally, offspring body mass index (BMI) z scores did not differ according to metformin exposure (mean difference 0.30 [95% CI −0.01–0.61]). Individual small studies reported that prenatal exposure to metformin was associated with greater mid-upper arm, head and waist circumferences, biceps skinfolds, waist-to-height ratio, more arm fat, higher fasting glucose, ferritin and lower LDL cholesterol in offspring. Conclusion: Prenatal exposure to metformin is associated with increas

Published
2018

25. Pessary for preterm birth prevention in twin pregnancy with short cervix: 3-year follow-up study

Author

Epi Methoden Team 4, JC onderzoeksprogramma Methodologie, van 't Hooft, Janneke, van der Lee, Johanna H, Opmeer, Brent C, van Wassenaer-Leemhuis, Aleid G, van Baar, Anneloes L, Bekedam, Dick J, Steenis, Leonie J P, Liem, Sophie, Schuit, Ewoud, Cuijpers, Cuny, Bleeker, Elise, Vinke, Margot E, Simons, Noor, de Graaf, Irene M, Mol, Ben Willem J, van de Beek, Cornelieke, Epi Methoden Team 4, JC onderzoeksprogramma Methodologie, van 't Hooft, Janneke, van der Lee, Johanna H, Opmeer, Brent C, van Wassenaer-Leemhuis, Aleid G, van Baar, Anneloes L, Bekedam, Dick J, Steenis, Leonie J P, Liem, Sophie, Schuit, Ewoud, Cuijpers, Cuny, Bleeker, Elise, Vinke, Margot E, Simons, Noor, de Graaf, Irene M, Mol, Ben Willem J, and van de Beek, Cornelieke

Published
2018

26. Very preterm born children at early school age: Healthcare therapies and educational provisions

Author

van Veen, S., Aarnoudse-Moens, C.S.H., Oosterlaan, J., van Sonderen, L., de Haan, T. R., van Kaam, A. H., van Wassenaer-Leemhuis, A. G., van Veen, S., Aarnoudse-Moens, C.S.H., Oosterlaan, J., van Sonderen, L., de Haan, T. R., van Kaam, A. H., and van Wassenaer-Leemhuis, A. G.

Abstract

Aim To explore changes in motor and cognitive outcomes in very preterm (VP; gestational age < 30 weeks) born children between ages five and six years, and to determine whether changes in these outcomes were associated with the use of healthcare therapies and educational provisions. Study design Single-center observational cohort study. Five-year-old VP born children of a one-year-cohort of our neonatal follow-up program (N = 90) were invited for re-assessments at age six. Use of healthcare therapies and educational provisions was registered at ages five and six years. Motor function (Movement Assessment Battery for Children-2 [M-ABC-2]; higher scores indicate better functioning) and IQ (Wechsler Preschool and Primary Scale for Intelligence [WPPSI-III-NL]) were assessed at both ages. Results Sixty-four VP born children were seen at ages five and at six years. In this year, 61% received healthcare therapies and/or educational provisions. M-ABC-2 scores of VP born children who received healthcare therapy and/or educational provisions were significantly higher (M = 8.9 [SD = 3.2]) at age six years than at age five years (M = 7.5 [SD = 3.3]); p < 0.00). M-ABC-2 scores remained stable in the average range in VP born children without any support. IQ scores remained stable irrespective of received support. Conclusions Improvements in motor outcomes are associated with the use of healthcare therapies and/or educational support between ages five and six years in VP born children. Future studies need to determine the efficacy of existing interventions, and to develop tailored interventions to support VP born children in the transfer period from preschool to primary education.

Published
2018
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27. How to monitor pregnancies complicated by fetal growth restriction and delivery before 32 weeks : post-hoc analysis of TRUFFLE study

Author

Ganzevoort, W., Mensing van Charante, N., Thilaganathan, B., Prefumo, Federico, Arabin, B., Bilardo, Caterina M., Brezinka, C., Derks, J. B., Diemert, A., Duvekot, Johannes J., Ferrazzi, E., Frusca, T., Hecher, K., Marlow, N., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Schlembach, D., Schneider, K. T M, Todros, T., Valcamonico, A., Visser, G. H.A., van Wassenaer-Leemhuis, A., Lees, Christoph C., Wolf, H., Aktas, Ayse, Borgione, Silvia, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, J., Fratelli, Nicola, van Haastert, I. C., Lobmaier, Silvia, Lopriore, E., Missfelder-Lobos, Hannah, Mansi, Giuseppina, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Mulder-De Tollenaer, Susanne, Napolitano, Raffaele, Oberto, Manuela, Oepkes, D., Ogge, Giovanna, van der Post, Joris A. M., Preston, Lucy, Raimondi, Francesco, Rattue, H., Reiss, Irwin K M, on behalf of the TRUFFLE Group, Ganzevoort, W., Mensing van Charante, N., Thilaganathan, B., Prefumo, Federico, Arabin, B., Bilardo, Caterina M., Brezinka, C., Derks, J. B., Diemert, A., Duvekot, Johannes J., Ferrazzi, E., Frusca, T., Hecher, K., Marlow, N., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Schlembach, D., Schneider, K. T M, Todros, T., Valcamonico, A., Visser, G. H.A., van Wassenaer-Leemhuis, A., Lees, Christoph C., Wolf, H., Aktas, Ayse, Borgione, Silvia, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, J., Fratelli, Nicola, van Haastert, I. C., Lobmaier, Silvia, Lopriore, E., Missfelder-Lobos, Hannah, Mansi, Giuseppina, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Mulder-De Tollenaer, Susanne, Napolitano, Raffaele, Oberto, Manuela, Oepkes, D., Ogge, Giovanna, van der Post, Joris A. M., Preston, Lucy, Raimondi, Francesco, Rattue, H., Reiss, Irwin K M, and on behalf of the TRUFFLE Group

Published
2017

28. Is middle cerebral artery Doppler related to neonatal and 2-year infant outcome in early fetal growth restriction?

Author

Stampalija, Tamara, Arabin, Birgit, Wolf, Hans, Bilardo, Caterina M., Lees, Christoph, Brezinka, C., Derks, J. B., Diemert, A., Duvekot, J. J., Ferrazzi, E., Frusca, T., Ganzevoort, W., Hecher, K., Kingdom, J., Marlow, N., Marsal, K., Martinelli, P., Ostermayer, E., Papageorghiou, A. T., Schlembach, D., Schneider, K. T.M., Thilaganathan, B., Thornton, J., Todros, T., Valcamonico, A., Valensise, H., van Wassenaer-Leemhuis, A., Visser, GHA, Aktas, A., Borgione, S., Chaoui, R., Cornette, J. M.J., Diehl, T., van Eyck, J., Fratelli, N., van Haastert, I. C., Lobmaier, S., Lopriore, E., Missfelder-Lobos, H., Mansi, G., Martelli, P., Maso, G., Maurer-Fellbaum, U., Mensing van Charante, N., Mulder-de Tollenaer, S., Napolitano, R., Oberto, M., Oepkes, D., Ogge, G., van der Post, J. A.M., Prefumo, F., Preston, L., Raimondi, F., Reiss, I. K.M., Scheepers, L. S., Skabar, A., Spaanderman, M., Weisglas-Kuperus, N., Zimmermann, A., Stampalija, Tamara, Arabin, Birgit, Wolf, Hans, Bilardo, Caterina M., Lees, Christoph, Brezinka, C., Derks, J. B., Diemert, A., Duvekot, J. J., Ferrazzi, E., Frusca, T., Ganzevoort, W., Hecher, K., Kingdom, J., Marlow, N., Marsal, K., Martinelli, P., Ostermayer, E., Papageorghiou, A. T., Schlembach, D., Schneider, K. T.M., Thilaganathan, B., Thornton, J., Todros, T., Valcamonico, A., Valensise, H., van Wassenaer-Leemhuis, A., Visser, GHA, Aktas, A., Borgione, S., Chaoui, R., Cornette, J. M.J., Diehl, T., van Eyck, J., Fratelli, N., van Haastert, I. C., Lobmaier, S., Lopriore, E., Missfelder-Lobos, H., Mansi, G., Martelli, P., Maso, G., Maurer-Fellbaum, U., Mensing van Charante, N., Mulder-de Tollenaer, S., Napolitano, R., Oberto, M., Oepkes, D., Ogge, G., van der Post, J. A.M., Prefumo, F., Preston, L., Raimondi, F., Reiss, I. K.M., Scheepers, L. S., Skabar, A., Spaanderman, M., Weisglas-Kuperus, N., and Zimmermann, A.

Published
2017

29. Longitudinal study of computerized cardiotocography in early fetal growth restriction

Author

Wolf, H., Arabin, B., Lees, Christoph C., Oepkes, D., Prefumo, Federico, Thilaganathan, B., Todros, T., Visser, G.H.A., Bilardo, Caterina M., Derks, J. B., Diemert, A., Duvekot, Johannes J., Ferrazzi, E., Frusca, T., Hecher, K., Marlow, N., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Scheepers, Hubertina C. J., Schlembach, D., Schneider, K. T M, Valcamonico, A., van Wassenaer-Leemhuis, A., Ganzevoort, W., Aktas, Ayse, Borgione, Silvia, Brezinka, Christoph, Calvert, Sandra, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, Jim, Fratelli, Nicola, van Haastert, Inge Lot, Johnson, Samantha, Lobmaier, Silvia, Lopriore, Enrico, Mansi, Giuseppina, Missfelder-Lobos, Hannah, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Van Charante, Nico Mensing, De Tollenaer, Susanne Mulder, Moore, Tamanna, Napolitano, Raffaele, Oberto, Manuela, Ogge, Giovanna, Schuit, Ewoud, on behalf of the TRUFFLE group, Wolf, H., Arabin, B., Lees, Christoph C., Oepkes, D., Prefumo, Federico, Thilaganathan, B., Todros, T., Visser, G.H.A., Bilardo, Caterina M., Derks, J. B., Diemert, A., Duvekot, Johannes J., Ferrazzi, E., Frusca, T., Hecher, K., Marlow, N., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Scheepers, Hubertina C. J., Schlembach, D., Schneider, K. T M, Valcamonico, A., van Wassenaer-Leemhuis, A., Ganzevoort, W., Aktas, Ayse, Borgione, Silvia, Brezinka, Christoph, Calvert, Sandra, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, Jim, Fratelli, Nicola, van Haastert, Inge Lot, Johnson, Samantha, Lobmaier, Silvia, Lopriore, Enrico, Mansi, Giuseppina, Missfelder-Lobos, Hannah, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Van Charante, Nico Mensing, De Tollenaer, Susanne Mulder, Moore, Tamanna, Napolitano, Raffaele, Oberto, Manuela, Ogge, Giovanna, Schuit, Ewoud, and on behalf of the TRUFFLE group

Published
2017

30. STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction): An international consortium of randomised placebo-controlled trials

Author

Pels, A, Kenny, LC, Alfirevic, Z, Baker, PN, von Dadelszen, P, Gluud, C, Kariya, CT, Mol, BW, Papageorghiou, A, van Wassenaer-Leemhuis, AG, Ganzevoort, W, Groom, KM, McCowan, LM, Stone, PR, Lee, A, Mackay, L, Oyston, C, Gardener, G, Khashan, A, Eustace, J, Dempsey, E, Jackson, R, Dickinson, J, Gill, A, Muller, P, Sekar, R, Reid, RA, Unterschneider, J, Welsh, A, Marlow, J, Hyett, J, Walker, S, Morris, J, Watson, D, McKinlay, C, Harris, S, Lim, KI, Lalji, S, Magee, LA, Lee, T, Li, J, Hutfield, A, Ansermino, M, Robinson, W, Singer, J, Synnes, AR, Burrows, J, Audibert, F, Bujold, E, Piedboeuf, B, Davidge, ST, Seaward, GR, Dwinnell, S, Gagnon, R, Gaudet, L, Young, C, Murphy, D, Daly, S, McAuliffe, F, Malone, F, Breathnach, F, O'Donoghue, K, Al-Nasiry, S, de Boer, MA, de Groot, CJM, Sueters, M, Derks, JB, van Drongelen, J, Duvekot, HJ, Elvan-Taspinar, A, van Eyck, J, van Laar, J, Morssink, LP, Price, L, Astor, A, Hardman, L, Sharp, A, Turner, M, Cameron, A, Draper, E, Clarke, P, Mckelvey, A, Masson, G, Aquilin, J, Johnstone, E, Bugg, G, Howe, D, Patni, S, Mousa, H, Russell, H, Hannon, T, Kilby, M, David, A, Cohen, K, Impey, L, Stock, S, Poon, L, Pasupath, D, Khalil, A, Pels, A, Kenny, LC, Alfirevic, Z, Baker, PN, von Dadelszen, P, Gluud, C, Kariya, CT, Mol, BW, Papageorghiou, A, van Wassenaer-Leemhuis, AG, Ganzevoort, W, Groom, KM, McCowan, LM, Stone, PR, Lee, A, Mackay, L, Oyston, C, Gardener, G, Khashan, A, Eustace, J, Dempsey, E, Jackson, R, Dickinson, J, Gill, A, Muller, P, Sekar, R, Reid, RA, Unterschneider, J, Welsh, A, Marlow, J, Hyett, J, Walker, S, Morris, J, Watson, D, McKinlay, C, Harris, S, Lim, KI, Lalji, S, Magee, LA, Lee, T, Li, J, Hutfield, A, Ansermino, M, Robinson, W, Singer, J, Synnes, AR, Burrows, J, Audibert, F, Bujold, E, Piedboeuf, B, Davidge, ST, Seaward, GR, Dwinnell, S, Gagnon, R, Gaudet, L, Young, C, Murphy, D, Daly, S, McAuliffe, F, Malone, F, Breathnach, F, O'Donoghue, K, Al-Nasiry, S, de Boer, MA, de Groot, CJM, Sueters, M, Derks, JB, van Drongelen, J, Duvekot, HJ, Elvan-Taspinar, A, van Eyck, J, van Laar, J, Morssink, LP, Price, L, Astor, A, Hardman, L, Sharp, A, Turner, M, Cameron, A, Draper, E, Clarke, P, Mckelvey, A, Masson, G, Aquilin, J, Johnstone, E, Bugg, G, Howe, D, Patni, S, Mousa, H, Russell, H, Hannon, T, Kilby, M, David, A, Cohen, K, Impey, L, Stock, S, Poon, L, Pasupath, D, and Khalil, A

Abstract

Background: Severe, early-onset fetal growth restriction due to placental insufficiency is associated with a high risk of perinatal mortality and morbidity with long-lasting sequelae. Placental insufficiency is the result of abnormal formation and function of the placenta with inadequate remodelling of the maternal spiral arteries. There is currently no effective therapy available. Some evidence suggests sildenafil citrate may improve uteroplacental blood flow, fetal growth, and meaningful infant outcomes. The objective of the Sildenafil TheRapy In Dismal prognosis Early onset fetal growth Restriction (STRIDER) collaboration is to evaluate the effectiveness of sildenafil versus placebo in achieving healthy perinatal survival through the conduct of randomised clinical trials and systematic review including individual patient data meta-analysis. Methods: Five national/bi-national multicentre randomised placebo-controlled trials have been launched. Women with a singleton pregnancy between 18 and 30 weeks with severe fetal growth restriction of likely placental origin, and where the likelihood of perinatal death/severe morbidity is estimated to be significant are included. Participants will receive either sildenafil 25 mg or matching placebo tablets orally three times daily from recruitment to 32 weeks gestation. Discussion: The STRIDER trials were conceived and designed through international collaboration. Although the individual trials have different primary outcomes for reasons of sample size and feasibility, all trials will collect a standard set of outcomes including survival without severe neonatal morbidity at time of hospital discharge. This is a summary of all the STRIDER trial protocols and provides an example of a prospectively planned international clinical research collaboration. All five individual trials will contribute to a pre-planned systematic review of the topic including individual patient data meta-analysis.

Published
2017

31. Longitudinal study of computerized cardiotocography in early fetal growth restriction

Author

Wolf, H., Arabin, B., Lees, Christoph C., Oepkes, D., Prefumo, Federico, Thilaganathan, B., Todros, T., Visser, G.H.A., Bilardo, Caterina M., Derks, J. B., Diemert, A., Duvekot, Johannes J., Ferrazzi, E., Frusca, T., Hecher, K., Marlow, N., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Scheepers, Hubertina C. J., Schlembach, D., Schneider, K. T M, Valcamonico, A., van Wassenaer-Leemhuis, A., Ganzevoort, W., Aktas, Ayse, Borgione, Silvia, Brezinka, Christoph, Calvert, Sandra, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, Jim, Fratelli, Nicola, van Haastert, Inge Lot, Johnson, Samantha, Lobmaier, Silvia, Lopriore, Enrico, Mansi, Giuseppina, Missfelder-Lobos, Hannah, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Van Charante, Nico Mensing, De Tollenaer, Susanne Mulder, Moore, Tamanna, Napolitano, Raffaele, Oberto, Manuela, Ogge, Giovanna, Schuit, Ewoud, on behalf of the TRUFFLE group, Wolf, H., Arabin, B., Lees, Christoph C., Oepkes, D., Prefumo, Federico, Thilaganathan, B., Todros, T., Visser, G.H.A., Bilardo, Caterina M., Derks, J. B., Diemert, A., Duvekot, Johannes J., Ferrazzi, E., Frusca, T., Hecher, K., Marlow, N., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Scheepers, Hubertina C. J., Schlembach, D., Schneider, K. T M, Valcamonico, A., van Wassenaer-Leemhuis, A., Ganzevoort, W., Aktas, Ayse, Borgione, Silvia, Brezinka, Christoph, Calvert, Sandra, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, Jim, Fratelli, Nicola, van Haastert, Inge Lot, Johnson, Samantha, Lobmaier, Silvia, Lopriore, Enrico, Mansi, Giuseppina, Missfelder-Lobos, Hannah, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Van Charante, Nico Mensing, De Tollenaer, Susanne Mulder, Moore, Tamanna, Napolitano, Raffaele, Oberto, Manuela, Ogge, Giovanna, Schuit, Ewoud, and on behalf of the TRUFFLE group

Published
2017

32. Is middle cerebral artery Doppler related to neonatal and 2-year infant outcome in early fetal growth restriction?

Author

Stampalija, Tamara, Arabin, Birgit, Wolf, Hans, Bilardo, Caterina M., Lees, Christoph, Brezinka, C., Derks, J. B., Diemert, A., Duvekot, J. J., Ferrazzi, E., Frusca, T., Ganzevoort, W., Hecher, K., Kingdom, J., Marlow, N., Marsal, K., Martinelli, P., Ostermayer, E., Papageorghiou, A. T., Schlembach, D., Schneider, K. T.M., Thilaganathan, B., Thornton, J., Todros, T., Valcamonico, A., Valensise, H., van Wassenaer-Leemhuis, A., Visser, GHA, Aktas, A., Borgione, S., Chaoui, R., Cornette, J. M.J., Diehl, T., van Eyck, J., Fratelli, N., van Haastert, I. C., Lobmaier, S., Lopriore, E., Missfelder-Lobos, H., Mansi, G., Martelli, P., Maso, G., Maurer-Fellbaum, U., Mensing van Charante, N., Mulder-de Tollenaer, S., Napolitano, R., Oberto, M., Oepkes, D., Ogge, G., van der Post, J. A.M., Prefumo, F., Preston, L., Raimondi, F., Reiss, I. K.M., Scheepers, L. S., Skabar, A., Spaanderman, M., Weisglas-Kuperus, N., Zimmermann, A., Stampalija, Tamara, Arabin, Birgit, Wolf, Hans, Bilardo, Caterina M., Lees, Christoph, Brezinka, C., Derks, J. B., Diemert, A., Duvekot, J. J., Ferrazzi, E., Frusca, T., Ganzevoort, W., Hecher, K., Kingdom, J., Marlow, N., Marsal, K., Martinelli, P., Ostermayer, E., Papageorghiou, A. T., Schlembach, D., Schneider, K. T.M., Thilaganathan, B., Thornton, J., Todros, T., Valcamonico, A., Valensise, H., van Wassenaer-Leemhuis, A., Visser, GHA, Aktas, A., Borgione, S., Chaoui, R., Cornette, J. M.J., Diehl, T., van Eyck, J., Fratelli, N., van Haastert, I. C., Lobmaier, S., Lopriore, E., Missfelder-Lobos, H., Mansi, G., Martelli, P., Maso, G., Maurer-Fellbaum, U., Mensing van Charante, N., Mulder-de Tollenaer, S., Napolitano, R., Oberto, M., Oepkes, D., Ogge, G., van der Post, J. A.M., Prefumo, F., Preston, L., Raimondi, F., Reiss, I. K.M., Scheepers, L. S., Skabar, A., Spaanderman, M., Weisglas-Kuperus, N., and Zimmermann, A.

Published
2017

33. How to monitor pregnancies complicated by fetal growth restriction and delivery before 32 weeks : post-hoc analysis of TRUFFLE study

Author

Ganzevoort, W., Mensing van Charante, N., Thilaganathan, B., Prefumo, Federico, Arabin, B., Bilardo, Caterina M., Brezinka, C., Derks, J. B., Diemert, A., Duvekot, Johannes J., Ferrazzi, E., Frusca, T., Hecher, K., Marlow, N., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Schlembach, D., Schneider, K. T M, Todros, T., Valcamonico, A., Visser, G. H.A., van Wassenaer-Leemhuis, A., Lees, Christoph C., Wolf, H., Aktas, Ayse, Borgione, Silvia, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, J., Fratelli, Nicola, van Haastert, I. C., Lobmaier, Silvia, Lopriore, E., Missfelder-Lobos, Hannah, Mansi, Giuseppina, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Mulder-De Tollenaer, Susanne, Napolitano, Raffaele, Oberto, Manuela, Oepkes, D., Ogge, Giovanna, van der Post, Joris A. M., Preston, Lucy, Raimondi, Francesco, Rattue, H., Reiss, Irwin K M, on behalf of the TRUFFLE Group, Ganzevoort, W., Mensing van Charante, N., Thilaganathan, B., Prefumo, Federico, Arabin, B., Bilardo, Caterina M., Brezinka, C., Derks, J. B., Diemert, A., Duvekot, Johannes J., Ferrazzi, E., Frusca, T., Hecher, K., Marlow, N., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Schlembach, D., Schneider, K. T M, Todros, T., Valcamonico, A., Visser, G. H.A., van Wassenaer-Leemhuis, A., Lees, Christoph C., Wolf, H., Aktas, Ayse, Borgione, Silvia, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, J., Fratelli, Nicola, van Haastert, I. C., Lobmaier, Silvia, Lopriore, E., Missfelder-Lobos, Hannah, Mansi, Giuseppina, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Mulder-De Tollenaer, Susanne, Napolitano, Raffaele, Oberto, Manuela, Oepkes, D., Ogge, Giovanna, van der Post, Joris A. M., Preston, Lucy, Raimondi, Francesco, Rattue, H., Reiss, Irwin K M, and on behalf of the TRUFFLE Group

Published
2017

34. STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction): an international consortium of randomised placebo-controlled trials.

Author

Pels, A, Kenny, LC, Alfirevic, Z, Baker, PN, von Dadelszen, P, Gluud, C, Kariya, CT, Mol, BW, Papageorghiou, AT, van Wassenaer-Leemhuis, AG, Ganzevoort, W, Groom, KM, international STRIDER Consortium, Pels, A, Kenny, LC, Alfirevic, Z, Baker, PN, von Dadelszen, P, Gluud, C, Kariya, CT, Mol, BW, Papageorghiou, AT, van Wassenaer-Leemhuis, AG, Ganzevoort, W, Groom, KM, and international STRIDER Consortium

Abstract

BACKGROUND: Severe, early-onset fetal growth restriction due to placental insufficiency is associated with a high risk of perinatal mortality and morbidity with long-lasting sequelae. Placental insufficiency is the result of abnormal formation and function of the placenta with inadequate remodelling of the maternal spiral arteries. There is currently no effective therapy available. Some evidence suggests sildenafil citrate may improve uteroplacental blood flow, fetal growth, and meaningful infant outcomes. The objective of the Sildenafil TheRapy In Dismal prognosis Early onset fetal growth Restriction (STRIDER) collaboration is to evaluate the effectiveness of sildenafil versus placebo in achieving healthy perinatal survival through the conduct of randomised clinical trials and systematic review including individual patient data meta-analysis. METHODS: Five national/bi-national multicentre randomised placebo-controlled trials have been launched. Women with a singleton pregnancy between 18 and 30 weeks with severe fetal growth restriction of likely placental origin, and where the likelihood of perinatal death/severe morbidity is estimated to be significant are included. Participants will receive either sildenafil 25 mg or matching placebo tablets orally three times daily from recruitment to 32 weeks gestation. DISCUSSION: The STRIDER trials were conceived and designed through international collaboration. Although the individual trials have different primary outcomes for reasons of sample size and feasibility, all trials will collect a standard set of outcomes including survival without severe neonatal morbidity at time of hospital discharge. This is a summary of all the STRIDER trial protocols and provides an example of a prospectively planned international clinical research collaboration. All five individual trials will contribute to a pre-planned systematic review of the topic including individual patient data meta-analysis. TRIAL REGISTRATIONS: New Zealand and Aus

Published
2017

35. Longitudinal study of computerized cardiotocography in early fetal growth restriction

Author

Wolf, H., Arabin, B., Lees, Christoph C., Oepkes, D., Prefumo, Federico, Thilaganathan, B., Todros, T., Visser, G.H.A., Bilardo, Caterina M., Derks, J. B., Diemert, A., Duvekot, Johannes J., Ferrazzi, E., Frusca, T., Hecher, K., Marlow, N., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Scheepers, Hubertina C. J., Schlembach, D., Schneider, K. T M, Valcamonico, A., van Wassenaer-Leemhuis, A., Ganzevoort, W., Aktas, Ayse, Borgione, Silvia, Brezinka, Christoph, Calvert, Sandra, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, Jim, Fratelli, Nicola, van Haastert, Inge Lot, Johnson, Samantha, Lobmaier, Silvia, Lopriore, Enrico, Mansi, Giuseppina, Missfelder-Lobos, Hannah, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Van Charante, Nico Mensing, De Tollenaer, Susanne Mulder, Moore, Tamanna, Napolitano, Raffaele, Oberto, Manuela, Ogge, Giovanna, Schuit, Ewoud, on behalf of the TRUFFLE group, Wolf, H., Arabin, B., Lees, Christoph C., Oepkes, D., Prefumo, Federico, Thilaganathan, B., Todros, T., Visser, G.H.A., Bilardo, Caterina M., Derks, J. B., Diemert, A., Duvekot, Johannes J., Ferrazzi, E., Frusca, T., Hecher, K., Marlow, N., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Scheepers, Hubertina C. J., Schlembach, D., Schneider, K. T M, Valcamonico, A., van Wassenaer-Leemhuis, A., Ganzevoort, W., Aktas, Ayse, Borgione, Silvia, Brezinka, Christoph, Calvert, Sandra, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, Jim, Fratelli, Nicola, van Haastert, Inge Lot, Johnson, Samantha, Lobmaier, Silvia, Lopriore, Enrico, Mansi, Giuseppina, Missfelder-Lobos, Hannah, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Van Charante, Nico Mensing, De Tollenaer, Susanne Mulder, Moore, Tamanna, Napolitano, Raffaele, Oberto, Manuela, Ogge, Giovanna, Schuit, Ewoud, and on behalf of the TRUFFLE group

Published
2017

36. How to monitor pregnancies complicated by fetal growth restriction and delivery before 32 weeks : post-hoc analysis of TRUFFLE study

Author

Ganzevoort, W., Mensing van Charante, N., Thilaganathan, B., Prefumo, Federico, Arabin, B., Bilardo, Caterina M., Brezinka, C., Derks, J. B., Diemert, A., Duvekot, Johannes J., Ferrazzi, E., Frusca, T., Hecher, K., Marlow, N., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Schlembach, D., Schneider, K. T M, Todros, T., Valcamonico, A., Visser, G. H.A., van Wassenaer-Leemhuis, A., Lees, Christoph C., Wolf, H., Aktas, Ayse, Borgione, Silvia, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, J., Fratelli, Nicola, van Haastert, I. C., Lobmaier, Silvia, Lopriore, E., Missfelder-Lobos, Hannah, Mansi, Giuseppina, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Mulder-De Tollenaer, Susanne, Napolitano, Raffaele, Oberto, Manuela, Oepkes, D., Ogge, Giovanna, van der Post, Joris A. M., Preston, Lucy, Raimondi, Francesco, Rattue, H., Reiss, Irwin K M, on behalf of the TRUFFLE Group, Ganzevoort, W., Mensing van Charante, N., Thilaganathan, B., Prefumo, Federico, Arabin, B., Bilardo, Caterina M., Brezinka, C., Derks, J. B., Diemert, A., Duvekot, Johannes J., Ferrazzi, E., Frusca, T., Hecher, K., Marlow, N., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Schlembach, D., Schneider, K. T M, Todros, T., Valcamonico, A., Visser, G. H.A., van Wassenaer-Leemhuis, A., Lees, Christoph C., Wolf, H., Aktas, Ayse, Borgione, Silvia, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, J., Fratelli, Nicola, van Haastert, I. C., Lobmaier, Silvia, Lopriore, E., Missfelder-Lobos, Hannah, Mansi, Giuseppina, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Mulder-De Tollenaer, Susanne, Napolitano, Raffaele, Oberto, Manuela, Oepkes, D., Ogge, Giovanna, van der Post, Joris A. M., Preston, Lucy, Raimondi, Francesco, Rattue, H., Reiss, Irwin K M, and on behalf of the TRUFFLE Group

Published
2017

37. Is middle cerebral artery Doppler related to neonatal and 2-year infant outcome in early fetal growth restriction?

Author

Stampalija, Tamara, Arabin, Birgit, Wolf, Hans, Bilardo, Caterina M., Lees, Christoph, Brezinka, C., Derks, J. B., Diemert, A., Duvekot, J. J., Ferrazzi, E., Frusca, T., Ganzevoort, W., Hecher, K., Kingdom, J., Marlow, N., Marsal, K., Martinelli, P., Ostermayer, E., Papageorghiou, A. T., Schlembach, D., Schneider, K. T.M., Thilaganathan, B., Thornton, J., Todros, T., Valcamonico, A., Valensise, H., van Wassenaer-Leemhuis, A., Visser, GHA, Aktas, A., Borgione, S., Chaoui, R., Cornette, J. M.J., Diehl, T., van Eyck, J., Fratelli, N., van Haastert, I. C., Lobmaier, S., Lopriore, E., Missfelder-Lobos, H., Mansi, G., Martelli, P., Maso, G., Maurer-Fellbaum, U., Mensing van Charante, N., Mulder-de Tollenaer, S., Napolitano, R., Oberto, M., Oepkes, D., Ogge, G., van der Post, J. A.M., Prefumo, F., Preston, L., Raimondi, F., Reiss, I. K.M., Scheepers, L. S., Skabar, A., Spaanderman, M., Weisglas-Kuperus, N., Zimmermann, A., Stampalija, Tamara, Arabin, Birgit, Wolf, Hans, Bilardo, Caterina M., Lees, Christoph, Brezinka, C., Derks, J. B., Diemert, A., Duvekot, J. J., Ferrazzi, E., Frusca, T., Ganzevoort, W., Hecher, K., Kingdom, J., Marlow, N., Marsal, K., Martinelli, P., Ostermayer, E., Papageorghiou, A. T., Schlembach, D., Schneider, K. T.M., Thilaganathan, B., Thornton, J., Todros, T., Valcamonico, A., Valensise, H., van Wassenaer-Leemhuis, A., Visser, GHA, Aktas, A., Borgione, S., Chaoui, R., Cornette, J. M.J., Diehl, T., van Eyck, J., Fratelli, N., van Haastert, I. C., Lobmaier, S., Lopriore, E., Missfelder-Lobos, H., Mansi, G., Martelli, P., Maso, G., Maurer-Fellbaum, U., Mensing van Charante, N., Mulder-de Tollenaer, S., Napolitano, R., Oberto, M., Oepkes, D., Ogge, G., van der Post, J. A.M., Prefumo, F., Preston, L., Raimondi, F., Reiss, I. K.M., Scheepers, L. S., Skabar, A., Spaanderman, M., Weisglas-Kuperus, N., and Zimmermann, A.

Published
2017

38. How to monitor pregnancies complicated by fetal growth restriction and delivery before 32 weeks: post-hoc analysis of TRUFFLE study

Author

MS Verloskunde, Other research (not in main researchprogram), MS Neonatologie, Brain, Ganzevoort, W., Mensing van Charante, N., Thilaganathan, B., Prefumo, Federico, Arabin, B., Bilardo, Caterina M., Brezinka, C., Derks, J. B., Diemert, A., Duvekot, Johannes J., Ferrazzi, E., Frusca, T., Hecher, K., Marlow, N., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Schlembach, D., Schneider, K. T M, Todros, T., Valcamonico, A., Visser, G. H.A., van Wassenaer-Leemhuis, A., Lees, Christoph C., Wolf, H., Aktas, Ayse, Borgione, Silvia, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, J., Fratelli, Nicola, van Haastert, I. C., Lobmaier, Silvia, Lopriore, E., Missfelder-Lobos, Hannah, Mansi, Giuseppina, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Mulder-De Tollenaer, Susanne, Napolitano, Raffaele, Oberto, Manuela, Oepkes, D., Ogge, Giovanna, van der Post, Joris A. M., Preston, Lucy, Raimondi, Francesco, Rattue, H., Reiss, Irwin K M, on behalf of the TRUFFLE Group, MS Verloskunde, Other research (not in main researchprogram), MS Neonatologie, Brain, Ganzevoort, W., Mensing van Charante, N., Thilaganathan, B., Prefumo, Federico, Arabin, B., Bilardo, Caterina M., Brezinka, C., Derks, J. B., Diemert, A., Duvekot, Johannes J., Ferrazzi, E., Frusca, T., Hecher, K., Marlow, N., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Schlembach, D., Schneider, K. T M, Todros, T., Valcamonico, A., Visser, G. H.A., van Wassenaer-Leemhuis, A., Lees, Christoph C., Wolf, H., Aktas, Ayse, Borgione, Silvia, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, J., Fratelli, Nicola, van Haastert, I. C., Lobmaier, Silvia, Lopriore, E., Missfelder-Lobos, Hannah, Mansi, Giuseppina, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Mulder-De Tollenaer, Susanne, Napolitano, Raffaele, Oberto, Manuela, Oepkes, D., Ogge, Giovanna, van der Post, Joris A. M., Preston, Lucy, Raimondi, Francesco, Rattue, H., Reiss, Irwin K M, and on behalf of the TRUFFLE Group

Published
2017

39. Is middle cerebral artery Doppler related to neonatal and 2-year infant outcome in early fetal growth restriction?

Author

MS Verloskunde, Other research (not in main researchprogram), MS Neonatologie, Brain, Stampalija, Tamara, Arabin, Birgit, Wolf, Hans, Bilardo, Caterina M., Lees, Christoph, Brezinka, C., Derks, J. B., Diemert, A., Duvekot, J. J., Ferrazzi, E., Frusca, T., Ganzevoort, W., Hecher, K., Kingdom, J., Marlow, N., Marsal, K., Martinelli, P., Ostermayer, E., Papageorghiou, A. T., Schlembach, D., Schneider, K. T.M., Thilaganathan, B., Thornton, J., Todros, T., Valcamonico, A., Valensise, H., van Wassenaer-Leemhuis, A., Visser, GHA, Aktas, A., Borgione, S., Chaoui, R., Cornette, J. M.J., Diehl, T., van Eyck, J., Fratelli, N., van Haastert, I. C., Lobmaier, S., Lopriore, E., Missfelder-Lobos, H., Mansi, G., Martelli, P., Maso, G., Maurer-Fellbaum, U., Mensing van Charante, N., Mulder-de Tollenaer, S., Napolitano, R., Oberto, M., Oepkes, D., Ogge, G., van der Post, J. A.M., Prefumo, F., Preston, L., Raimondi, F., Reiss, I. K.M., Scheepers, L. S., Skabar, A., Spaanderman, M., Weisglas-Kuperus, N., Zimmermann, A., MS Verloskunde, Other research (not in main researchprogram), MS Neonatologie, Brain, Stampalija, Tamara, Arabin, Birgit, Wolf, Hans, Bilardo, Caterina M., Lees, Christoph, Brezinka, C., Derks, J. B., Diemert, A., Duvekot, J. J., Ferrazzi, E., Frusca, T., Ganzevoort, W., Hecher, K., Kingdom, J., Marlow, N., Marsal, K., Martinelli, P., Ostermayer, E., Papageorghiou, A. T., Schlembach, D., Schneider, K. T.M., Thilaganathan, B., Thornton, J., Todros, T., Valcamonico, A., Valensise, H., van Wassenaer-Leemhuis, A., Visser, GHA, Aktas, A., Borgione, S., Chaoui, R., Cornette, J. M.J., Diehl, T., van Eyck, J., Fratelli, N., van Haastert, I. C., Lobmaier, S., Lopriore, E., Missfelder-Lobos, H., Mansi, G., Martelli, P., Maso, G., Maurer-Fellbaum, U., Mensing van Charante, N., Mulder-de Tollenaer, S., Napolitano, R., Oberto, M., Oepkes, D., Ogge, G., van der Post, J. A.M., Prefumo, F., Preston, L., Raimondi, F., Reiss, I. K.M., Scheepers, L. S., Skabar, A., Spaanderman, M., Weisglas-Kuperus, N., and Zimmermann, A.

Published
2017

40. Longitudinal study of computerized cardiotocography in early fetal growth restriction

Author

MS Verloskunde, UMC Utrecht, Other research (not in main researchprogram), MS Neonatologie, Brain, Epi Methoden Team 4, Wolf, H., Arabin, B., Lees, Christoph C., Oepkes, D., Prefumo, Federico, Thilaganathan, B., Todros, T., Visser, G.H.A., Bilardo, Caterina M., Derks, J. B., Diemert, A., Duvekot, Johannes J., Ferrazzi, E., Frusca, T., Hecher, K., Marlow, N., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Scheepers, Hubertina C. J., Schlembach, D., Schneider, K. T M, Valcamonico, A., van Wassenaer-Leemhuis, A., Ganzevoort, W., Aktas, Ayse, Borgione, Silvia, Brezinka, Christoph, Calvert, Sandra, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, Jim, Fratelli, Nicola, van Haastert, Inge Lot, Johnson, Samantha, Lobmaier, Silvia, Lopriore, Enrico, Mansi, Giuseppina, Missfelder-Lobos, Hannah, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Van Charante, Nico Mensing, De Tollenaer, Susanne Mulder, Moore, Tamanna, Napolitano, Raffaele, Oberto, Manuela, Ogge, Giovanna, Schuit, Ewoud, The TRUFFLE group, MS Verloskunde, UMC Utrecht, Other research (not in main researchprogram), MS Neonatologie, Brain, Epi Methoden Team 4, Wolf, H., Arabin, B., Lees, Christoph C., Oepkes, D., Prefumo, Federico, Thilaganathan, B., Todros, T., Visser, G.H.A., Bilardo, Caterina M., Derks, J. B., Diemert, A., Duvekot, Johannes J., Ferrazzi, E., Frusca, T., Hecher, K., Marlow, N., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Scheepers, Hubertina C. J., Schlembach, D., Schneider, K. T M, Valcamonico, A., van Wassenaer-Leemhuis, A., Ganzevoort, W., Aktas, Ayse, Borgione, Silvia, Brezinka, Christoph, Calvert, Sandra, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, Jim, Fratelli, Nicola, van Haastert, Inge Lot, Johnson, Samantha, Lobmaier, Silvia, Lopriore, Enrico, Mansi, Giuseppina, Missfelder-Lobos, Hannah, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Van Charante, Nico Mensing, De Tollenaer, Susanne Mulder, Moore, Tamanna, Napolitano, Raffaele, Oberto, Manuela, Ogge, Giovanna, Schuit, Ewoud, and The TRUFFLE group

Published
2017

41. Longitudinal study of computerized cardiotocography in early fetal growth restriction

Author

Wolf, H, Arabin, B, Lees, CC, Oepkes, D, Prefumo, F, Thilaganathan, B, Todros, T, Visser, GHA, Bilardo, CM, Derks, JB, Diemert, A, Duvekot, J.J., Ferrazzi, E, Frusca, T, Hecher, K, Marlow, N, Martinelli, P, Ostermayer, E, Papageorghiou, AT, Scheepers, HCJ, Schlembach, D, Schneider, KTM, Valcamonico, A, van Wassenaer-Leemhuis, A, Ganzevoort, W, Wolf, H, Arabin, B, Lees, CC, Oepkes, D, Prefumo, F, Thilaganathan, B, Todros, T, Visser, GHA, Bilardo, CM, Derks, JB, Diemert, A, Duvekot, J.J., Ferrazzi, E, Frusca, T, Hecher, K, Marlow, N, Martinelli, P, Ostermayer, E, Papageorghiou, AT, Scheepers, HCJ, Schlembach, D, Schneider, KTM, Valcamonico, A, van Wassenaer-Leemhuis, A, and Ganzevoort, W

Published
2017

42. Phase-rectified signal averaging method to predict perinatal outcome in infants with very preterm fetal growth restriction- a secondary analysis of TRUFFLE-trial

Author

Lobmaier, Silvia M., Mensing van Charante, Nico, Ferrazzi, Enrico, Giussani, Dino A., Shaw, Caroline J., Müller, Alexander, Ortiz, Javier U., Ostermayer, Eva, Haller, Bernhard, Prefumo, Federico, Frusca, Tiziana, Hecher, Kurt, Arabin, Birgit, Thilaganathan, Baskaran, Papageorghiou, Aris T., Bhide, Amarnath, Martinelli, Pasquale, Duvekot, Johannes J., van Eyck, Jim, Visser, Gerard H A, Schmidt, Georg, Ganzevoort, Wessel, Lees, Christoph C., Schneider, Karl T M, Bilardo, Caterina M., Brezinka, Christoph, Diemert, Anke, Derks, Jan B., Schlembach, Dietmar, Todros, Tullia, Valcamonico, Adriana, Marlow, Neil, van Wassenaer-Leemhuis, Aleid, Lobmaier, Silvia M., Mensing van Charante, Nico, Ferrazzi, Enrico, Giussani, Dino A., Shaw, Caroline J., Müller, Alexander, Ortiz, Javier U., Ostermayer, Eva, Haller, Bernhard, Prefumo, Federico, Frusca, Tiziana, Hecher, Kurt, Arabin, Birgit, Thilaganathan, Baskaran, Papageorghiou, Aris T., Bhide, Amarnath, Martinelli, Pasquale, Duvekot, Johannes J., van Eyck, Jim, Visser, Gerard H A, Schmidt, Georg, Ganzevoort, Wessel, Lees, Christoph C., Schneider, Karl T M, Bilardo, Caterina M., Brezinka, Christoph, Diemert, Anke, Derks, Jan B., Schlembach, Dietmar, Todros, Tullia, Valcamonico, Adriana, Marlow, Neil, and van Wassenaer-Leemhuis, Aleid

Published
2016

43. Maintenance tocolysis with nifedipine in threatened preterm labour : 2-year follow up of the offspring in the APOSTEL II trial

Author

van Vliet, E.O.G., Seinen, L., Roos, C., Schuit, E., Scheepers, H. C J, Bloemenkamp, K. W M, Duvekot, J. J., van Eyck, J., Kok, J. H., Lotgering, F. K., van Baar, A., van Wassenaer-Leemhuis, A. G., Franssen, M. T., Porath, M. M., van der Post, J. A M, Franx, A., Mol, B. W J, Oudijk, M. A., van Vliet, E.O.G., Seinen, L., Roos, C., Schuit, E., Scheepers, H. C J, Bloemenkamp, K. W M, Duvekot, J. J., van Eyck, J., Kok, J. H., Lotgering, F. K., van Baar, A., van Wassenaer-Leemhuis, A. G., Franssen, M. T., Porath, M. M., van der Post, J. A M, Franx, A., Mol, B. W J, and Oudijk, M. A.

Published
2016

44. Phase-rectified signal averaging method to predict perinatal outcome in infants with very preterm fetal growth restriction- a secondary analysis of TRUFFLE-trial

Author

Lobmaier, Silvia M., Mensing van Charante, Nico, Ferrazzi, Enrico, Giussani, Dino A., Shaw, Caroline J., Müller, Alexander, Ortiz, Javier U., Ostermayer, Eva, Haller, Bernhard, Prefumo, Federico, Frusca, Tiziana, Hecher, Kurt, Arabin, Birgit, Thilaganathan, Baskaran, Papageorghiou, Aris T., Bhide, Amarnath, Martinelli, Pasquale, Duvekot, Johannes J., van Eyck, Jim, Visser, Gerard H A, Schmidt, Georg, Ganzevoort, Wessel, Lees, Christoph C., Schneider, Karl T M, Bilardo, Caterina M., Brezinka, Christoph, Diemert, Anke, Derks, Jan B., Schlembach, Dietmar, Todros, Tullia, Valcamonico, Adriana, Marlow, Neil, van Wassenaer-Leemhuis, Aleid, Lobmaier, Silvia M., Mensing van Charante, Nico, Ferrazzi, Enrico, Giussani, Dino A., Shaw, Caroline J., Müller, Alexander, Ortiz, Javier U., Ostermayer, Eva, Haller, Bernhard, Prefumo, Federico, Frusca, Tiziana, Hecher, Kurt, Arabin, Birgit, Thilaganathan, Baskaran, Papageorghiou, Aris T., Bhide, Amarnath, Martinelli, Pasquale, Duvekot, Johannes J., van Eyck, Jim, Visser, Gerard H A, Schmidt, Georg, Ganzevoort, Wessel, Lees, Christoph C., Schneider, Karl T M, Bilardo, Caterina M., Brezinka, Christoph, Diemert, Anke, Derks, Jan B., Schlembach, Dietmar, Todros, Tullia, Valcamonico, Adriana, Marlow, Neil, and van Wassenaer-Leemhuis, Aleid

Published
2016

45. Maintenance tocolysis with nifedipine in threatened preterm labour : 2-year follow up of the offspring in the APOSTEL II trial

Author

van Vliet, E.O.G., Seinen, L., Roos, C., Schuit, E., Scheepers, H. C J, Bloemenkamp, K. W M, Duvekot, J. J., van Eyck, J., Kok, J. H., Lotgering, F. K., van Baar, A., van Wassenaer-Leemhuis, A. G., Franssen, M. T., Porath, M. M., van der Post, J. A M, Franx, A., Mol, B. W J, Oudijk, M. A., van Vliet, E.O.G., Seinen, L., Roos, C., Schuit, E., Scheepers, H. C J, Bloemenkamp, K. W M, Duvekot, J. J., van Eyck, J., Kok, J. H., Lotgering, F. K., van Baar, A., van Wassenaer-Leemhuis, A. G., Franssen, M. T., Porath, M. M., van der Post, J. A M, Franx, A., Mol, B. W J, and Oudijk, M. A.

Published
2016

46. Maintenance tocolysis with nifedipine in threatened preterm labour: 2-year follow up of the offspring in the APOSTEL II trial

Author

Leerstoel Baar, Development and Treatment of Psychosocial Problems, Van Vliet, Eog, Seinen, L, Roos, C, Schuit, E, Scheepers, Hcj, Bloemenkamp, Kwm, Duvekot, Jj, Van Eyck, J, Kok, Jh, Lotgering, Fk, Van Baar, A, Van Wassenaer-leemhuis, Ag, Franssen, Mt, Porath, Mm, Van Der Post, Jam, Franx, A, Mol, Bwj, Oudijk, Ma, Leerstoel Baar, Development and Treatment of Psychosocial Problems, Van Vliet, Eog, Seinen, L, Roos, C, Schuit, E, Scheepers, Hcj, Bloemenkamp, Kwm, Duvekot, Jj, Van Eyck, J, Kok, Jh, Lotgering, Fk, Van Baar, A, Van Wassenaer-leemhuis, Ag, Franssen, Mt, Porath, Mm, Van Der Post, Jam, Franx, A, Mol, Bwj, and Oudijk, Ma

Published
2016

47. Maintenance tocolysis with nifedipine in threatened preterm labour : 2-year follow up of the offspring in the APOSTEL II trial

Author

van Vliet, E.O.G., Seinen, L., Roos, C., Schuit, E., Scheepers, H. C J, Bloemenkamp, K. W M, Duvekot, J. J., van Eyck, J., Kok, J. H., Lotgering, F. K., van Baar, A., van Wassenaer-Leemhuis, A. G., Franssen, M. T., Porath, M. M., van der Post, J. A M, Franx, A., Mol, B. W J, Oudijk, M. A., van Vliet, E.O.G., Seinen, L., Roos, C., Schuit, E., Scheepers, H. C J, Bloemenkamp, K. W M, Duvekot, J. J., van Eyck, J., Kok, J. H., Lotgering, F. K., van Baar, A., van Wassenaer-Leemhuis, A. G., Franssen, M. T., Porath, M. M., van der Post, J. A M, Franx, A., Mol, B. W J, and Oudijk, M. A.

Published
2016

48. Phase-rectified signal averaging method to predict perinatal outcome in infants with very preterm fetal growth restriction- a secondary analysis of TRUFFLE-trial

Author

Lobmaier, Silvia M., Mensing van Charante, Nico, Ferrazzi, Enrico, Giussani, Dino A., Shaw, Caroline J., Müller, Alexander, Ortiz, Javier U., Ostermayer, Eva, Haller, Bernhard, Prefumo, Federico, Frusca, Tiziana, Hecher, Kurt, Arabin, Birgit, Thilaganathan, Baskaran, Papageorghiou, Aris T., Bhide, Amarnath, Martinelli, Pasquale, Duvekot, Johannes J., van Eyck, Jim, Visser, Gerard H A, Schmidt, Georg, Ganzevoort, Wessel, Lees, Christoph C., Schneider, Karl T M, Bilardo, Caterina M., Brezinka, Christoph, Diemert, Anke, Derks, Jan B., Schlembach, Dietmar, Todros, Tullia, Valcamonico, Adriana, Marlow, Neil, van Wassenaer-Leemhuis, Aleid, Lobmaier, Silvia M., Mensing van Charante, Nico, Ferrazzi, Enrico, Giussani, Dino A., Shaw, Caroline J., Müller, Alexander, Ortiz, Javier U., Ostermayer, Eva, Haller, Bernhard, Prefumo, Federico, Frusca, Tiziana, Hecher, Kurt, Arabin, Birgit, Thilaganathan, Baskaran, Papageorghiou, Aris T., Bhide, Amarnath, Martinelli, Pasquale, Duvekot, Johannes J., van Eyck, Jim, Visser, Gerard H A, Schmidt, Georg, Ganzevoort, Wessel, Lees, Christoph C., Schneider, Karl T M, Bilardo, Caterina M., Brezinka, Christoph, Diemert, Anke, Derks, Jan B., Schlembach, Dietmar, Todros, Tullia, Valcamonico, Adriana, Marlow, Neil, and van Wassenaer-Leemhuis, Aleid

Published
2016

49. Maintenance tocolysis with nifedipine in threatened preterm labour: 2-year follow up of the offspring in the APOSTEL II trial

Author

Leerstoel Baar, Development and Treatment of Psychosocial Problems, Van Vliet, Eog, Seinen, L, Roos, C, Schuit, E, Scheepers, Hcj, Bloemenkamp, Kwm, Duvekot, Jj, Van Eyck, J, Kok, Jh, Lotgering, Fk, Van Baar, A, Van Wassenaer-leemhuis, Ag, Franssen, Mt, Porath, Mm, Van Der Post, Jam, Franx, A, Mol, Bwj, Oudijk, Ma, Leerstoel Baar, Development and Treatment of Psychosocial Problems, Van Vliet, Eog, Seinen, L, Roos, C, Schuit, E, Scheepers, Hcj, Bloemenkamp, Kwm, Duvekot, Jj, Van Eyck, J, Kok, Jh, Lotgering, Fk, Van Baar, A, Van Wassenaer-leemhuis, Ag, Franssen, Mt, Porath, Mm, Van Der Post, Jam, Franx, A, Mol, Bwj, and Oudijk, Ma

Published
2016

50. Phase-rectified signal averaging method to predict perinatal outcome in infants with very preterm fetal growth restriction- a secondary analysis of TRUFFLE-trial

Author

MS Verloskunde, Other research (not in main researchprogram), Lobmaier, Silvia M., Mensing van Charante, Nico, Ferrazzi, Enrico, Giussani, Dino A., Shaw, Caroline J., Müller, Alexander, Ortiz, Javier U., Ostermayer, Eva, Haller, Bernhard, Prefumo, Federico, Frusca, Tiziana, Hecher, Kurt, Arabin, Birgit, Thilaganathan, Baskaran, Papageorghiou, Aris T., Bhide, Amarnath, Martinelli, Pasquale, Duvekot, Johannes J., van Eyck, Jim, Visser, Gerard H A, Schmidt, Georg, Ganzevoort, Wessel, Lees, Christoph C., Schneider, Karl T M, Bilardo, Caterina M., Brezinka, Christoph, Diemert, Anke, Derks, Jan B., Schlembach, Dietmar, Todros, Tullia, Valcamonico, Adriana, Marlow, Neil, van Wassenaer-Leemhuis, Aleid, MS Verloskunde, Other research (not in main researchprogram), Lobmaier, Silvia M., Mensing van Charante, Nico, Ferrazzi, Enrico, Giussani, Dino A., Shaw, Caroline J., Müller, Alexander, Ortiz, Javier U., Ostermayer, Eva, Haller, Bernhard, Prefumo, Federico, Frusca, Tiziana, Hecher, Kurt, Arabin, Birgit, Thilaganathan, Baskaran, Papageorghiou, Aris T., Bhide, Amarnath, Martinelli, Pasquale, Duvekot, Johannes J., van Eyck, Jim, Visser, Gerard H A, Schmidt, Georg, Ganzevoort, Wessel, Lees, Christoph C., Schneider, Karl T M, Bilardo, Caterina M., Brezinka, Christoph, Diemert, Anke, Derks, Jan B., Schlembach, Dietmar, Todros, Tullia, Valcamonico, Adriana, Marlow, Neil, and van Wassenaer-Leemhuis, Aleid

Published
2016

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