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в статье представлены результаты многогодового проспективного клинического исследования по изучению маточно-плацентарного и плодового кровотока у беременных. В исследовании проведен отдельный углубленный анализ изолированных нарушений кровотока в бассейне маточных артерий по допплерометрическим данным после 18 недель гестации. Авторами выявлена связь нарушения маточно-плацентарной перфузии с очагами хронической инфекции различной локализации в организме беременной. Проведен сравнительный анализ корригирующей терапии при нарушениях маточно-плацентарной перфузии, включающий выявление и санацию очагов персистирующей инфекции (в т. ч. бессимптомных ее форм), а также применение препаратов, влияющих на тонус сосудистого русла и реологические свойства крови. Показана эффективность препарата дипиридамола при идиопатических нарушения маточно-плацентарной перфузии., the article presents the results of long-term prospective clinical research on uteroplacental and fetal blood flow of pregnant women. In the research they made a special in-depth analysis of single disturbance of blood flow in uterine artery basin according to Doppler measure data after 18-week gestation. They connect uteroplacental perfusion disturbance with chronic infection nidi (focus) of different location in the organism of pregnant woman. They made comparative analysis of correcting therapy, when there is an uteroplacental perfusion disturbance, including detection and elimination of persistent infection nidi (asymptomatic forms as well), and also application of medicaments that influence vascular tone and rheological properties of blood. They showed efficiency of Diripidamol when used for idiopathic disturbances of uteroplacental perfusion.

в статье представлены результаты многогодового проспективного клинического исследования по изучению маточно-плацентарного и плодового кровотока у беременных. В исследовании проведен отдельный углубленный анализ изолированных нарушений кровотока в бассейне маточных артерий по допплерометрическим данным после 18 недель гестации. Авторами выявлена связь нарушения маточно-плацентарной перфузии с очагами хронической инфекции различной локализации в организме беременной. Проведен сравнительный анализ корригирующей терапии при нарушениях маточно-плацентарной перфузии, включающий выявление и санацию очагов персистирующей инфекции (в т. ч. бессимптомных ее форм), а также применение препаратов, влияющих на тонус сосудистого русла и реологические свойства крови. Показана эффективность препарата дипиридамола при идиопатических нарушения маточно-плацентарной перфузии., the article presents the results of long-term prospective clinical research on uteroplacental and fetal blood flow of pregnant women. In the research they made a special in-depth analysis of single disturbance of blood flow in uterine artery basin according to Doppler measure data after 18-week gestation. They connect uteroplacental perfusion disturbance with chronic infection nidi (focus) of different location in the organism of pregnant woman. They made comparative analysis of correcting therapy, when there is an uteroplacental perfusion disturbance, including detection and elimination of persistent infection nidi (asymptomatic forms as well), and also application of medicaments that influence vascular tone and rheological properties of blood. They showed efficiency of Diripidamol when used for idiopathic disturbances of uteroplacental perfusion.

Objectives: To determine endometrial thickness, uterine and endometrial blood flow in postmenopausal women receiving hormone replacement therapy (HRT). Study design: forty hundred forty eight women were divided into six groups based on HRT. The endometrial thickness of all of them were examinated with Aloka 2000 and pulsatility and resistance index of uterine and endometrial arteries (if visible) were calculated. P < 0.05 was considered as significative. Result: The endometrial thickness was 2.8 mm ± 2.6 in group without HRT (n = 168), this endometrial thickness was significatively (p < 0.0001) lower than group with oestrogen alone: 8.7 mm ± 6, HRT sequential: 6.7 mm ± 3, HRT continous: 4 mm ± 3.1 (p<0.01), Progestagen alone: 8 mm ± 5.8 and Tibolone 6.7 mm ± 4. The mean RIs and PIs of uterine arteries are significantly lower in women receiving HRT (group 2-6) than women without HRT (0.72 ± 0.12 versus 0.92 ± 0.01) p < 0.01 and 2.16 ± 0.8 versus 2.46 ± 0.8 p < 0.01. The endometrial PI of 1.17 ± 0.4 in the HRT group was not significantly different from that in the no HRT group (1.85 ± 0.4) p = 0.06. Conclusion: The endometrial thickness was considerably lower with continous hormone replacement therapy around 4 mm. Moderate endometrial blood flow were present in all groups. The color doppler ultrasound reflects the hormonal status and change in the uterine and endometrial perfusion depending on hormonal therapy., SCOPUS: re.j, info:eu-repo/semantics/published

Objectives: To determine endometrial thickness, uterine and endometrial blood flow in postmenopausal women receiving hormone replacement therapy (HRT). Study design: forty hundred forty eight women were divided into six groups based on HRT. The endometrial thickness of all of them were examinated with Aloka 2000 and pulsatility and resistance index of uterine and endometrial arteries (if visible) were calculated. P < 0.05 was considered as significative. Result: The endometrial thickness was 2.8 mm ± 2.6 in group without HRT (n = 168), this endometrial thickness was significatively (p < 0.0001) lower than group with oestrogen alone: 8.7 mm ± 6, HRT sequential: 6.7 mm ± 3, HRT continous: 4 mm ± 3.1 (p<0.01), Progestagen alone: 8 mm ± 5.8 and Tibolone 6.7 mm ± 4. The mean RIs and PIs of uterine arteries are significantly lower in women receiving HRT (group 2-6) than women without HRT (0.72 ± 0.12 versus 0.92 ± 0.01) p < 0.01 and 2.16 ± 0.8 versus 2.46 ± 0.8 p < 0.01. The endometrial PI of 1.17 ± 0.4 in the HRT group was not significantly different from that in the no HRT group (1.85 ± 0.4) p = 0.06. Conclusion: The endometrial thickness was considerably lower with continous hormone replacement therapy around 4 mm. Moderate endometrial blood flow were present in all groups. The color doppler ultrasound reflects the hormonal status and change in the uterine and endometrial perfusion depending on hormonal therapy., SCOPUS: re.j, info:eu-repo/semantics/published

Objective: To evaluate the relationship between insulin levels and uter-oplacental vascular resistance in third-trimester pregnancies complicated by impaired carbohydrate tolerance. Methods: Fifty-two patients were admitted to the study. After a 3–h oral glucose tolerance test (OGTT), a color Doppler evaluation of uterine and umbilical arteries was performed. Results: According to O'Sullivan criteria, 14 patients had impaired gestational glucose tolerance (IGGT), 18 patients had gestational diabetes (GDM), and 20 subjects had normal glucose tolerance and served as controls. On the basis of the insulinemic response to OGTT, the patients were then classified as normoinsulinemic or hyperinsulinemic, with a cutoff value for the area under the curve of 240,360 pmol/L × 180 min. Hyperinsulinemic patients showed greater values of the “highest” uterine artery resistance index (RI) when compared to controls (P < 0.01); the “lowest” uterine artery RI was slightly, but not significantly, increased. Moreover, a significant linear correlation was found between insulin response to OGTT and “highest” uterine artery RI (P < 0.034, r = 0.29), as well as between insulin and diastolic blood pressure (DBP) (P < 0.001, r = 0.47); DBP was also significantly related to the “highest” uterine artery RI (P < 0.033, r = 0.29). By contrast, no differences were found in the three groups with respect to umbilical artery pulsatility index (PI) and pregnancy outcome. Conclusions: From our preliminary study, we conclude that a relationship exists between insulin secretory patterns and uterine vascular indices in pregnancies complicated by carbohydrate intolerance, but the cause of this relationship is yet to be clarified; we cannot exclude a possible involvement of arterial blood pressure

To determine if uterine artery Doppler velocimetry is useful in identifying chronic hypertensive pregnancies at risk for superimposed preeclampsia and adverse perinatal outcome. Resistance index (RI) was assessed by color velocimetry at the level of uterine arteries at 23-24 weeks of gestation in 42 women with chronic hypertension. The "lowest", the "highest" and the "average" values were compared to select the most predictive index for superimposed preeclampsia, intrauterine growth retardation (IUGR), birth weight lower than 2500 g and gestational age at delivery less than 36 weeks. Nine patients developed superimposed preeclampsia (21%) and 15 delivered before the 36th week of gestation (36%); 4 babies were IUGR (10%) and in 18 cases birth weights were below 2500 g (43%). Statistical analysis of Doppler findings showed that abnormal values of "lowest RI" were significantly correlated with adverse pregnancy outcome. Color Doppler analysis of uterine arteries is able to select chronic hypertensive pregnant women at risk of superimposed preeclampsia and poor perinatal outcome.