1. Severe veno-occlusive disease after autologous peripheral blood stem cell transplantation for high-grade non-Hodgkin lymphoma: report of a successfully managed case and a literature review of veno-occlusive disease.
- Author
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Palladino, Michele, Miele, Luca, Pompili, Maurizio, Forgione, Alessandra, Vellone, Valerio Gaetano, Vecchio, Fabio Maria, Chiusolo, Patrizia, Laurenti, Luca, Gasbarrini, Giovanni Battista, Sica, Simona, Grieco, Antonio, Miele, Luca (ORCID:0000-0003-3464-0068), Pompili, Maurizio (ORCID:0000-0001-6699-7980), Vecchio, Fabio Maria (ORCID:0000-0002-9197-2264), Chiusolo, Patrizia (ORCID:0000-0002-1355-1587), Laurenti, Luca (ORCID:0000-0002-8327-1396), Sica, Simona (ORCID:0000-0003-2426-3465), Grieco, Antonio (ORCID:0000-0002-0544-8993), Palladino, Michele, Miele, Luca, Pompili, Maurizio, Forgione, Alessandra, Vellone, Valerio Gaetano, Vecchio, Fabio Maria, Chiusolo, Patrizia, Laurenti, Luca, Gasbarrini, Giovanni Battista, Sica, Simona, Grieco, Antonio, Miele, Luca (ORCID:0000-0003-3464-0068), Pompili, Maurizio (ORCID:0000-0001-6699-7980), Vecchio, Fabio Maria (ORCID:0000-0002-9197-2264), Chiusolo, Patrizia (ORCID:0000-0002-1355-1587), Laurenti, Luca (ORCID:0000-0002-8327-1396), Sica, Simona (ORCID:0000-0003-2426-3465), and Grieco, Antonio (ORCID:0000-0002-0544-8993)
- Abstract
Veno-occlusive disease (VOD) of the liver is a severe complication of high-dose chemotherapy and allogeneic or autologous stem cell transplantation with potential fatal outcome. We report a case of severe VOD in a patient with a high-grade B-cell lymphoma. Liver-venule occlusion was confirmed by liver biopsy. Supportive care, fibrinolytic treatment with recombinant tissue plasminogen activator and defibrotide maintenance therapy led to complete resolution of VOD demonstrated at liver biopsy and with a follow-up of 44 months after autologous peripheral blood stem cell transplantation. The literature on VOD has been reviewed.
- Published
- 2008