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The collaboration of Yale, the University of California, Davis, and United Imaging Healthcare has successfully developed the NeuroEXPLORER, a dedicated human brain PET imager with high spatial resolution, high sensitivity, and a built-in 3-dimensional camera for markerless continuous motion tracking. It has high depth-of-interaction and time-of-flight resolutions, along with a 52.4-cm transverse field of view (FOV) and an extended axial FOV (49.5 cm) to enhance sensitivity. Here, we present the physical characterization, performance evaluation, and first human images of the NeuroEXPLORER. Methods: Measurements of spatial resolution, sensitivity, count rate performance, energy and timing resolution, and image quality were performed adhering to the National Electrical Manufacturers Association (NEMA) NU 2-2018 standard. The systems performance was demonstrated through imaging studies of the Hoffman 3-dimensional brain phantom and the mini-Derenzo phantom. Initial 18F-FDG images from a healthy volunteer are presented. Results: With filtered backprojection reconstruction, the radial and tangential spatial resolutions (full width at half maximum) averaged 1.64, 2.06, and 2.51 mm, with axial resolutions of 2.73, 2.89, and 2.93 mm for radial offsets of 1, 10, and 20 cm, respectively. The average time-of-flight resolution was 236 ps, and the energy resolution was 10.5%. NEMA sensitivities were 46.0 and 47.6 kcps/MBq at the center and 10-cm offset, respectively. A sensitivity of 11.8% was achieved at the FOV center. The peak noise-equivalent count rate was 1.31 Mcps at 58.0 kBq/mL, and the scatter fraction at 5.3 kBq/mL was 36.5%. The maximum count rate error at the peak noise-equivalent count rate was less than 5%. At 3 iterations, the NEMA image-quality contrast recovery coefficients varied from 74.5% (10-mm sphere) to 92.6% (37-mm sphere), and background variability ranged from 3.1% to 1.4% at a contrast of 4.0:1. An example human brain 18F-FDG image exhibited very high r

The TRIMAGE project aims to develop a brain-dedicated PET/MR/EEG (Positron Emission Tomography/Magnetic Resonance/Electroencephalogram) system that is able to perform simultaneous PET, MR and EEG acquisitions. The PET component consists of a full ring with 18 sectors. Each sector includes three square detector modules based on dual sstaggered LYSO:Ce matrices read out by SiPMs. Using Monte Carlo simulations and following NEMA (National Electrical Manufacturers Association) guidelines, image quality procedures have been applied to evaluate the performance of the PET component of the system. The performance are reported in terms of spatial resolution, uniformity, recovery coefficient, spill over ratio, noise equivalent count rate (NECR) and scatter fraction. The results show that the TRIMAGE system is at the top of the current brain PET technologies.

The aim of study was to investigate development of perennial medicinal plant, Satureja montana L., cultivated in dry farming conditions of South Banat, Serbia, with use of black permeable mulch film. In the first two vegetations, the influence of fertilization and crop density on yields of the aboveground plant part (per plant and per m2) and on the content of total essential oil and its major constituents was observed. Overwintering survival, after late performed first harvest, and surviving ratio by the end of the second year of vegetation were 90.1% and 86.9%, respectively. Ratio between fresh and dry biomass (2.4:1) was not affected by tested treatments. The yield per plant was affected by the treatments only in the second year; in lower compared to higher crop density it was 25% higher, and in organic compared to mineral fertilization it was 19 % higher. In both years, crop density did not show significant effect on yield per unit area, while in case of fertilization, this yield was higher in organic fertilization compared to mineral in the first and the second year, 7% and 19%, respectively. The essential oil yields ranged from 0.8% to 0.9%, with the major constituent thymol (48.3-69.4%), followed by carvacrol, p-cymene and β-bisabolene. The essential oil yield did not depend on treatments, while the content of major constituents was significantly affected only by applied crop density. .

[ES] El desarrollo y uso de los robots en el entorno industrial es cada vez mayor, existen diferentes tipos de robot de acuerdo con su función en la factoría. El proyecto consta del diseño, modelado, construcción y programación de un robot paletizador a escala, basándose en diseño de los ya existentes en el mercado. El robot será destinado al uso docente por tanto será reproducible con impresión 3d y sus componentes son de bajo coste. Posee cuatro ejes controlados por un servomotor y 3 motores paso a paso que serán manejados utilizando un Arduino UNO y que gestionará los sensores de posición. Posee una interfaz gráfica de usuario diseñada y programada en Labview que sirve para controlar y comunicarse con el robot. Este proyecto supone la confluencia de los distintos conocimientos obtenidos a lo largo de la carrera y la experiencia., [EN] The development and use of robots in the industrial environment is growing, there are different types of robots according to their function in the factory. The project consists of the design, modeling, construction and programming of a scale palletizing robot, based on the design of the existing ones in the market. The robot will be destined to the teaching use therefore it will be reproducible with 3d printing and its components are of low cost. It has four axes controlled by a servomotor and 3 stepper motors that will be managed using an Arduino UNO and that will manage the position sensors. It has a graphical user interface designed and programmed in Labview that serves to control and communicate with the robot. This project supposes the confluence of the different knowledge obtained throughout the career and experience., [CA] El desenvolupament i ús dels robots en l'entorn industrial és cada vegada més gran, hi ha diferents tipus de robot d'acord amb la seua funció en la factoria. El projecte consta del disseny, modelatge, construcció i programació d'un robot paletitzador a escala, basant-se en disseny dels ja existents en el mercat. El robot serà destinat a l'ús docent per tant serà reproduïble amb impressió 3D i els seus components són de baix cost. Posseeix quatre eixos controlats per un servomotor i 3 motors pas a pas que seran manejats per un Arduino UNO i que gestionarà els sensors de posició. Posseeix una interfície gràfica d'usuari dissenyada i programada en Labview que serveix per controlar i comunicar-se amb el robot. Aquest projecte suposa la confluència dels diferents coneixements obtinguts al llarg de la carrera i l'experiència.

[ES] Este Trabajo Fin de Máster nace de la colaboración de ITC Packaging S.L.U. y la Universidad Politécnica de Valencia. ITC es una de las empresas líderes, tanto nacional como europea en la transformación de termoplásticos para la industria alimentaria, así como para aplicaciones industriales tales como la pintura, detergentes, cosméticos, etc. Estando en TOP 3 a nivel nacional y en el 20 europeo. El trabajo se ha realizado en la planta de inyección de ITC Packaging en Ibi (Alicante) con la necesidad de automatizar y optimizar el movimiento de la visión artificial de los robots en el proceso de inyección de plástico. En la planta de inyección se fabrican diferentes tipos de productos en cuanto a tamaño y características físicas se refiere, lo que conlleva un cambio continuo de producto a fabricar. En el sistema anterior los técnicos realizan el proceso de cambio de forma manual, siendo difícil la colocación de las cámaras en la posición idónea. Por ese motivo y por la pérdida de tiempo que supone tener que ajustar las cámaras a mano, se opta por la automatización y optimización del movimiento, consiguiendo así un proceso más rápido y preciso. En el trabajo se explicará cada componente y material usado para la construcción de la estructura y cuadro eléctrico para la automatización del movimiento de la visión artificial, así como el proceso de montaje y por último la instalación en el robot. También se explicará el código programado, tanto para el microcontrolador, como el programado para la pantalla táctil. Los objetivos principales de la automatización y optimización del proceso se basan en la reducción del tiempo de ajuste por parte del técnico con su correspondiente ahorro económico, así como la disminución de los posibles riesgos laborales producidos por el sistema anterior., [EN] This Master's Thesis was born from the collaboration of ITC Packaging S.L.U. and the Polytechnic University of Valencia. ITC is one of the leading companies, both national and European in the transformation of thermoplastics for the food industry, as well as for industrial applications such as paint, detergents, cosmetics, etc. Being in TOP 3 nationally and in European 20. The work has been carried out in the ITC Packaging injection plant in Ibi (Alicante) with the need to automate and optimize the movement of the artificial vision of the robots in the plastic injection process. In the injection plant, different types of products are manufactured in terms of size and physical characteristics, which entails a continuous change of the product to be manufactured. In the previous system the technicians carry out the process of change manually, being difficult to place the cameras in the ideal position. For this reason and for the loss of time involved in having to adjust the cameras by hand, we opt for the automation and optimization of movement, thus achieving a faster and more accurate process. In the work will explain each component and material used for the construction of the structure and electrical panel for the automation of the movement of the artificial vision, as well as the assembly process and finally the installation in the robot. The programmed code will also be explained, both for the microcontroller, as programmed for the touch screen. The main objectives of the automation and optimization of the process are based on the reduction of the adjustment time by the technician with its corresponding economic savings, as well as the reduction of the possible labor risks produced by the previous system.

[ES] Este Trabajo Fin de Máster nace de la colaboración de ITC Packaging S.L.U. y la Universidad Politécnica de Valencia. ITC es una de las empresas líderes, tanto nacional como europea en la transformación de termoplásticos para la industria alimentaria, así como para aplicaciones industriales tales como la pintura, detergentes, cosméticos, etc. Estando en TOP 3 a nivel nacional y en el 20 europeo. El trabajo se ha realizado en la planta de inyección de ITC Packaging en Ibi (Alicante) con la necesidad de automatizar y optimizar el movimiento de la visión artificial de los robots en el proceso de inyección de plástico. En la planta de inyección se fabrican diferentes tipos de productos en cuanto a tamaño y características físicas se refiere, lo que conlleva un cambio continuo de producto a fabricar. En el sistema anterior los técnicos realizan el proceso de cambio de forma manual, siendo difícil la colocación de las cámaras en la posición idónea. Por ese motivo y por la pérdida de tiempo que supone tener que ajustar las cámaras a mano, se opta por la automatización y optimización del movimiento, consiguiendo así un proceso más rápido y preciso. En el trabajo se explicará cada componente y material usado para la construcción de la estructura y cuadro eléctrico para la automatización del movimiento de la visión artificial, así como el proceso de montaje y por último la instalación en el robot. También se explicará el código programado, tanto para el microcontrolador, como el programado para la pantalla táctil. Los objetivos principales de la automatización y optimización del proceso se basan en la reducción del tiempo de ajuste por parte del técnico con su correspondiente ahorro económico, así como la disminución de los posibles riesgos laborales producidos por el sistema anterior., [EN] This Master's Thesis was born from the collaboration of ITC Packaging S.L.U. and the Polytechnic University of Valencia. ITC is one of the leading companies, both national and European in the transformation of thermoplastics for the food industry, as well as for industrial applications such as paint, detergents, cosmetics, etc. Being in TOP 3 nationally and in European 20. The work has been carried out in the ITC Packaging injection plant in Ibi (Alicante) with the need to automate and optimize the movement of the artificial vision of the robots in the plastic injection process. In the injection plant, different types of products are manufactured in terms of size and physical characteristics, which entails a continuous change of the product to be manufactured. In the previous system the technicians carry out the process of change manually, being difficult to place the cameras in the ideal position. For this reason and for the loss of time involved in having to adjust the cameras by hand, we opt for the automation and optimization of movement, thus achieving a faster and more accurate process. In the work will explain each component and material used for the construction of the structure and electrical panel for the automation of the movement of the artificial vision, as well as the assembly process and finally the installation in the robot. The programmed code will also be explained, both for the microcontroller, as programmed for the touch screen. The main objectives of the automation and optimization of the process are based on the reduction of the adjustment time by the technician with its corresponding economic savings, as well as the reduction of the possible labor risks produced by the previous system.

[ES] El desarrollo de este proyecto consiste en el diseño y la fabricación de una cortadora láser controlada mediante una raspberry pi procurando que sea a la par económica y potente. Se pretende que sirva tanto a los neófitos que deseen aprender como a los que buscan una herramienta real que les sirva para desarrollar nuevos proyectos. Con esta premisa se hará uso de una impresora 3d para producir las piezas que se emplearán en la estructura y se intentará abaratar el coste de producción haciendo un estudio de los componentes para conseguir un presupuesto óptimo sin perder funcionalidad. Finalmente se hablará del software y el hardware que se ha usado para controlar los diversos componentes y como se ha configurado el sistema para facilitar su uso., [EN] The development of this project consists on the design and manufacture of a laser cutter controlled by a raspberry pi that will be at the same time economical and powerful so that it serves both neophytes who wish to learn and those who are looking for a real tool that will serve them to develop new projects. With this premise will make use of a 3d printer to produce the pieces that will be used in the structure and will try to lower the cost of production by making a study of the components to achieve an optimal budget without losing functionality. Finally we will talk about the software and hardware that has been used to control the various components and how the system has been configured to facilitate its use.

[ES] El desarrollo y uso de los robots en el entorno industrial es cada vez mayor, existen diferentes tipos de robot de acuerdo con su función en la factoría. El proyecto consta del diseño, modelado, construcción y programación de un robot paletizador a escala, basándose en diseño de los ya existentes en el mercado. El robot será destinado al uso docente por tanto será reproducible con impresión 3d y sus componentes son de bajo coste. Posee cuatro ejes controlados por un servomotor y 3 motores paso a paso que serán manejados utilizando un Arduino UNO y que gestionará los sensores de posición. Posee una interfaz gráfica de usuario diseñada y programada en Labview que sirve para controlar y comunicarse con el robot. Este proyecto supone la confluencia de los distintos conocimientos obtenidos a lo largo de la carrera y la experiencia., [EN] The development and use of robots in the industrial environment is growing, there are different types of robots according to their function in the factory. The project consists of the design, modeling, construction and programming of a scale palletizing robot, based on the design of the existing ones in the market. The robot will be destined to the teaching use therefore it will be reproducible with 3d printing and its components are of low cost. It has four axes controlled by a servomotor and 3 stepper motors that will be managed using an Arduino UNO and that will manage the position sensors. It has a graphical user interface designed and programmed in Labview that serves to control and communicate with the robot. This project supposes the confluence of the different knowledge obtained throughout the career and experience., [CA] El desenvolupament i ús dels robots en l'entorn industrial és cada vegada més gran, hi ha diferents tipus de robot d'acord amb la seua funció en la factoria. El projecte consta del disseny, modelatge, construcció i programació d'un robot paletitzador a escala, basant-se en disseny dels ja existents en el mercat. El robot serà destinat a l'ús docent per tant serà reproduïble amb impressió 3D i els seus components són de baix cost. Posseeix quatre eixos controlats per un servomotor i 3 motors pas a pas que seran manejats per un Arduino UNO i que gestionarà els sensors de posició. Posseeix una interfície gràfica d'usuari dissenyada i programada en Labview que serveix per controlar i comunicar-se amb el robot. Aquest projecte suposa la confluència dels diferents coneixements obtinguts al llarg de la carrera i l'experiència.

[ES] Este Trabajo Fin de Máster nace de la colaboración de ITC Packaging S.L.U. y la Universidad Politécnica de Valencia. ITC es una de las empresas líderes, tanto nacional como europea en la transformación de termoplásticos para la industria alimentaria, así como para aplicaciones industriales tales como la pintura, detergentes, cosméticos, etc. Estando en TOP 3 a nivel nacional y en el 20 europeo. El trabajo se ha realizado en la planta de inyección de ITC Packaging en Ibi (Alicante) con la necesidad de automatizar y optimizar el movimiento de la visión artificial de los robots en el proceso de inyección de plástico. En la planta de inyección se fabrican diferentes tipos de productos en cuanto a tamaño y características físicas se refiere, lo que conlleva un cambio continuo de producto a fabricar. En el sistema anterior los técnicos realizan el proceso de cambio de forma manual, siendo difícil la colocación de las cámaras en la posición idónea. Por ese motivo y por la pérdida de tiempo que supone tener que ajustar las cámaras a mano, se opta por la automatización y optimización del movimiento, consiguiendo así un proceso más rápido y preciso. En el trabajo se explicará cada componente y material usado para la construcción de la estructura y cuadro eléctrico para la automatización del movimiento de la visión artificial, así como el proceso de montaje y por último la instalación en el robot. También se explicará el código programado, tanto para el microcontrolador, como el programado para la pantalla táctil. Los objetivos principales de la automatización y optimización del proceso se basan en la reducción del tiempo de ajuste por parte del técnico con su correspondiente ahorro económico, así como la disminución de los posibles riesgos laborales producidos por el sistema anterior., [EN] This Master's Thesis was born from the collaboration of ITC Packaging S.L.U. and the Polytechnic University of Valencia. ITC is one of the leading companies, both national and European in the transformation of thermoplastics for the food industry, as well as for industrial applications such as paint, detergents, cosmetics, etc. Being in TOP 3 nationally and in European 20. The work has been carried out in the ITC Packaging injection plant in Ibi (Alicante) with the need to automate and optimize the movement of the artificial vision of the robots in the plastic injection process. In the injection plant, different types of products are manufactured in terms of size and physical characteristics, which entails a continuous change of the product to be manufactured. In the previous system the technicians carry out the process of change manually, being difficult to place the cameras in the ideal position. For this reason and for the loss of time involved in having to adjust the cameras by hand, we opt for the automation and optimization of movement, thus achieving a faster and more accurate process. In the work will explain each component and material used for the construction of the structure and electrical panel for the automation of the movement of the artificial vision, as well as the assembly process and finally the installation in the robot. The programmed code will also be explained, both for the microcontroller, as programmed for the touch screen. The main objectives of the automation and optimization of the process are based on the reduction of the adjustment time by the technician with its corresponding economic savings, as well as the reduction of the possible labor risks produced by the previous system.

[ES] El desarrollo de este proyecto consiste en el diseño y la fabricación de una cortadora láser controlada mediante una raspberry pi procurando que sea a la par económica y potente. Se pretende que sirva tanto a los neófitos que deseen aprender como a los que buscan una herramienta real que les sirva para desarrollar nuevos proyectos. Con esta premisa se hará uso de una impresora 3d para producir las piezas que se emplearán en la estructura y se intentará abaratar el coste de producción haciendo un estudio de los componentes para conseguir un presupuesto óptimo sin perder funcionalidad. Finalmente se hablará del software y el hardware que se ha usado para controlar los diversos componentes y como se ha configurado el sistema para facilitar su uso., [EN] The development of this project consists on the design and manufacture of a laser cutter controlled by a raspberry pi that will be at the same time economical and powerful so that it serves both neophytes who wish to learn and those who are looking for a real tool that will serve them to develop new projects. With this premise will make use of a 3d printer to produce the pieces that will be used in the structure and will try to lower the cost of production by making a study of the components to achieve an optimal budget without losing functionality. Finally we will talk about the software and hardware that has been used to control the various components and how the system has been configured to facilitate its use.

[ES] El desarrollo y uso de los robots en el entorno industrial es cada vez mayor, existen diferentes tipos de robot de acuerdo con su función en la factoría. El proyecto consta del diseño, modelado, construcción y programación de un robot paletizador a escala, basándose en diseño de los ya existentes en el mercado. El robot será destinado al uso docente por tanto será reproducible con impresión 3d y sus componentes son de bajo coste. Posee cuatro ejes controlados por un servomotor y 3 motores paso a paso que serán manejados utilizando un Arduino UNO y que gestionará los sensores de posición. Posee una interfaz gráfica de usuario diseñada y programada en Labview que sirve para controlar y comunicarse con el robot. Este proyecto supone la confluencia de los distintos conocimientos obtenidos a lo largo de la carrera y la experiencia., [EN] The development and use of robots in the industrial environment is growing, there are different types of robots according to their function in the factory. The project consists of the design, modeling, construction and programming of a scale palletizing robot, based on the design of the existing ones in the market. The robot will be destined to the teaching use therefore it will be reproducible with 3d printing and its components are of low cost. It has four axes controlled by a servomotor and 3 stepper motors that will be managed using an Arduino UNO and that will manage the position sensors. It has a graphical user interface designed and programmed in Labview that serves to control and communicate with the robot. This project supposes the confluence of the different knowledge obtained throughout the career and experience., [CA] El desenvolupament i ús dels robots en l'entorn industrial és cada vegada més gran, hi ha diferents tipus de robot d'acord amb la seua funció en la factoria. El projecte consta del disseny, modelatge, construcció i programació d'un robot paletitzador a escala, basant-se en disseny dels ja existents en el mercat. El robot serà destinat a l'ús docent per tant serà reproduïble amb impressió 3D i els seus components són de baix cost. Posseeix quatre eixos controlats per un servomotor i 3 motors pas a pas que seran manejats per un Arduino UNO i que gestionarà els sensors de posició. Posseeix una interfície gràfica d'usuari dissenyada i programada en Labview que serveix per controlar i comunicar-se amb el robot. Aquest projecte suposa la confluència dels diferents coneixements obtinguts al llarg de la carrera i l'experiència.

This doctoral dissertation was focused on the optimization of the extraction parameters to achieve the maximum yield of phenolic compounds in the Urtica dioica L. leaf extracts. The extract with the highest content of phenolic compounds was tested in the model of experimental hypertension to determine its effects on oxidative and hemodynamic status, lipid profile, and biochemical parameters. It was shown that the most abundant phenolic compounds present in extracts of Urtica dioica L. were chlorogenic acid, 2-O-caffeoyl malic acid, and rutin. It was shown that aqueous-methanol is a better solvent for the extraction of phenolic compounds compared to aqueous-ethanol and water. Also, extracts prepared using ultrasound-assisted extraction technique had higher phenolic yields and antioxidant capacities than extracts obtained by maceration. The maximal content of phenolic compounds in the Urtica dioica L. leaf extracts was achieved by ultrasound-assisted extraction with 54% aqueous-methanol and 38 min extraction time. It was shown that the methanol percentage in the extraction solvent significantly affects phenolic yield, unlike the extraction time. Results of in vivo study showed that four-week long treatment with Urtica dioica L. leaf extract decreased arterial pressure and improved systemic oxidative status of spontaneously hypertensive rats, as well as the lipid status by increasing plasma HDL cholesterol and decreasing atherosclerosis-index.

This doctoral dissertation was focused on the optimization of the extraction parameters to achieve the maximum yield of phenolic compounds in the Urtica dioica L. leaf extracts. The extract with the highest content of phenolic compounds was tested in the model of experimental hypertension to determine its effects on oxidative and hemodynamic status, lipid profile, and biochemical parameters. It was shown that the most abundant phenolic compounds present in extracts of Urtica dioica L. were chlorogenic acid, 2-O-caffeoyl malic acid, and rutin. It was shown that aqueous-methanol is a better solvent for the extraction of phenolic compounds compared to aqueous-ethanol and water. Also, extracts prepared using ultrasound-assisted extraction technique had higher phenolic yields and antioxidant capacities than extracts obtained by maceration. The maximal content of phenolic compounds in the Urtica dioica L. leaf extracts was achieved by ultrasound-assisted extraction with 54% aqueous-methanol and 38 min extraction time. It was shown that the methanol percentage in the extraction solvent significantly affects phenolic yield, unlike the extraction time. Results of in vivo study showed that four-week long treatment with Urtica dioica L. leaf extract decreased arterial pressure and improved systemic oxidative status of spontaneously hypertensive rats, as well as the lipid status by increasing plasma HDL cholesterol and decreasing atherosclerosis-index.

Marshmallow (Althaea officinalis L.) root is used as a drug in medicine, pharmaceutical, cosmetic as well as in food products, due to the content of mucilage with a broad range of physicochemical properties. Since mucilage content in roots depends on genotype and growing conditions, the quality control is, therefore, one of the major tasks in the rational use of the drug. In this paper we compare data for mucilage content in roots obtained by standard procedure which implies measuring of swelling ratio in dried samples, with anatomical features of roots obtained by different methods for anatomical analysis, and we have shown that anatomical method could be used for determination of mucilage content in marshmallow root.

In this study, water and various concentrations of ethanol in water (30 %, 50 %, 70 %, and 90 %) were used as a solvent in the extraction of two different samples of hemp (Cannabis sativa L.). The extraction yield, total phenols content, total flavonoids content, antioxidant activity, and reductive capacity were determined in the obtained extracts. The extraction yield was from 8.16 to 19.56 %, the content of total phenols was in the range from 5.85 to 17.05 mg GAE/g dw, and content of total flavonoids was in the range from 5.85 to 9.25 mg CE/g dw. Antioxidant activity was tested by DPPH assay and EC50 values were from 0.1331 to 0.7563 mg/mL, while EC50 values obtained by reducing power test ranged from 0.4450 to 1.1980 mg/mL. Ethanol/water mixture (50 %) was determined to be the best solvent for the extraction of phenolic compounds from both hemp samples. Total phenols content in 50 % ethanolic extracts were 17.05 mg/g dw and 9.25 mg/g dw for young and mature hemp, respectively.

Medicinal plant extracts (MPE) have a broad antimicrobial activity, including antiviral effects. In our study, eleven dry extract of ten different medicinal plant prepared with two solvents (5%, dimethyl sulfoxide (DMSO) and 30% ethanol in 5% DMSO) in different concentrations have been examined for anti-noroviral activity. The reduction of norovirus > 1 log10 genome equivalents (GE) has been obtained with 1 mg/mL of Aronia melanocarpa leaf extract (AMLE), dried wine Prokupac (WPE) and Hypericum perforatum extract (HyPE). Some of MPE i.e. HyPE, Aronia melanocarpa fruit extract (AMFE) and Punica granatum (PPE) showed better activity when dissolved in 30% ethanol with 5% DMSO. All results of anti-noroviral activity of tested MPE which achieve lt 0.5 log10 GE are considered as not effective.

This article presents system performance studies of the Discovery MI PET/CT system, a new time-of-flight (TOF) system based on silicon photomultipliers. System performance and clinical imaging comparisons were made between this next-generation system and other commercially available PET/CT and PET/MR systems, as well as between different reconstruction algorithms. Methods: Spatial resolution, sensitivity, NECR, scatter fraction, count rate accuracy, and image quality were characterized with the NEMA NU-2 2012 standards. Energy and coincidence time resolution were measured. Tests were conducted independently and results were averaged on two Discovery MI scanners installed at Stanford and Uppsala University Hospitals. Back-to-back patient scans were also performed between the Discovery MI PET/CT, Discovery 690 PET/CT, and SIGNA PET/MR systems. Clinical images were reconstructed with both ordered-subset expectation maximization (OSEM) and the "Q.Clear" reconstruction algorithms, and examined qualitatively. Results: The averaged full-width half max (FWHM) of the radial/tangential/axial spatial resolution reconstructed with FBP at 1, 10, and 20 cm from the system center are, respectively, 4.10/4.19/4.48 mm, 5.47/4.49/6.01 mm, and 7.53/4.90/6.10 mm. The averaged sensitivity is 13.7 cps/kBq at the center of the FOV. Averaged peak noise equivalent count rate is 193.4 kcps at 21.9 kBq/mL with a scatter fraction of 40.6%. The averaged contrast recovery coefficients for the image quality phantom are 53.7/64.0/73.1/82.7/86.8/90.7 for the 10/13/17/22/28/37 mm diameter spheres. The average photopeak energy resolution is 9.40% FWHM and the average coincidence time resolution is 375.4 ps FWHM. Clinical image comparisons between the PET/CT systems demonstrate the high quality of the Discovery MI system. Comparisons between the Discovery MI and SIGNA systems show similar spatial resolution and overall imaging performance. Lastly, results indicate significant image quality and contras

El proyecto se enmarca en el campo de la Informática Médica y, más en concreto, en el de la Radiología Digital. En él se explicará el estado actual en que se encuentra este campo, habiendo introducido previamente sus inicios, para finalmente tratar de vislumbrar hacia dónde se dirige en los próximos años.

El proyecto se enmarca en el campo de la Informática Médica y, más en concreto, en el de la Radiología Digital. En él se explicará el estado actual en que se encuentra este campo, habiendo introducido previamente sus inicios, para finalmente tratar de vislumbrar hacia dónde se dirige en los próximos años.

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Book review

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Book review

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nema, nema

Nema

NEma

Nema