This thesis provides a firm mathematical foundation for nonlinear systems of singular, second order boundary value problems (BVPs). In particular, we shall advance the current state of knowledge by answering the question: âWhen do nonlinear systems of singular BVPs have solutions?â. The significance of these singular problems lies in their application to science, engineering, medicine and technology, where traditional nonâsingular problems are unsuitable.The thesis is divided into two parts, each of which treats the different nonlinear forms: Singular BVPs with derivative independence in the right hand side, Singular BVPs with derivative dependence in the right hand side.Discussing the above cases separately enables the content herein to evolve naturally. The methods include topological techniques and fixed point theory to obtain existence of solutions. Underpinning these ideas are determining a priori bounds on possible solutions to the BVPs. These bounds are achieved via the application of new differential inequalities, which, in turn, enable novel existence results.In the derivative independent case, there are two distinct inequalities that are investigated that both deal with problems without growth restrictions. The first inequality stems from Lyapunov functions and uses the equivalent integral representation of the BVP to prove that every possible solution to the BVP satisfies a particular a priori bound. The latter inequality achieves the same conclusion, however uses the technique of maximum principles instead. Under the assumptions of these bounds, topological techniques are applied to obtain the existence of solutions for systems of singular, second order BVP.Next, for the derivative dependent case; the same ideas apply. The pronounced difference between the forms is the dependence of the derivative term in the right hand side of the problem. This naturally gives rise to a particular discussion on finding a priori bounds for the derivative of possibl