1. A TA/Cu2+ Nanoparticle Enhanced Carboxymethyl Chitosan-Based Hydrogel Dressing with Antioxidant Properties and Promoting Wound Healing
- Author
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Huang,Yongjun, Chen,Yong, Cheng,Guoyun, Li,Wenqiang, Zhang,Hongan, Yu,Chaoqun, Fang,Jia, Zuo,Jieyi, Li,Ying, Xu,Lei, Sun,Dawei, Huang,Yongjun, Chen,Yong, Cheng,Guoyun, Li,Wenqiang, Zhang,Hongan, Yu,Chaoqun, Fang,Jia, Zuo,Jieyi, Li,Ying, Xu,Lei, and Sun,Dawei
- Abstract
Yongjun Huang,1,* Yong Chen,2,* Guoyun Cheng,1,* Wenqiang Li,3 Hongan Zhang,1,4 Chaoqun Yu,1 Jia Fang,1 Jieyi Zuo,1 Ying Li,1 Lei Xu,1 Dawei Sun1 1Department of Orthopedics, Guangdong Second Provincial General Hospital, Guangzhou, 510317, Peopleâs Republic of China; 2Department of Orthopedics, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan, Peopleâs Hospital, Qingyuan, 511518, Peopleâs Republic of China; 3Engineering Technology Research Center for Sports Assistive Devices of Guangdong, Guangzhou Sport University, Guangzhou, 510500, Peopleâs Republic of China; 4The Second Clinical School of Medicine, Southern Medical University, Guangzhou, 510260, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Lei Xu; Dawei Sun, Department of Orthopedics, Guangdong Second Provincial General Hospital, 11th Floor, Building 3, No. 466, Xingang Middle Road, Guangzhou, Guangdong Province, 510317, Peopleâs Republic of China, Email orthoxl@163.com; sundw@gd2h.org.cnBackground: As the first line of immune defense and the largest organ of body, skin is vulnerable to damage caused by surgery, burns, collisions and other factors. Wound healing in the skin is a long and complex physiological process that is influenced by a number of different factors. Proper wound care can greatly improve the speed of wound healing and reduce the generation of scars. However, traditional wound dressings (bandages, gauze, etc.) often used in clinical practice have a single function, lack of active ingredients and are limited in use. Hydrogels with three-dimensional network structure are a potential biomedical material because of their physical and chemical environment similar to extracellular matrix. In particular, hydrogel dressings with low price, good biocompatibility, degradability, antibacterial and angiogenic activity are favored by the public.Methods: Here, a carboxymethyl chitosan-based hydrogel
- Published
- 2024