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Region-adaptive normalization (RAN) methods have been widely used in the generative adversarial network (GAN)-based image-to-image translation technique. However, since these approaches need a mask image to infer the pixel-wise affine transformation parameters, they cannot be applied to the general image generation models having no paired mask images. To resolve this problem, this paper presents a novel normalization method, called self pixel-wise normalization (SPN), which effectively boosts the generative performance by performing the pixel-adaptive affine transformation without the mask image. In our method, the transforming parameters are derived from a self-latent mask that divides the feature map into the foreground and background regions. The visualization of the self-latent masks shows that SPN effectively captures a single object to be generated as the foreground. Since the proposed method produces the self-latent mask without external data, it is easily applicable in the existing generative models. Extensive experiments on various datasets reveal that the proposed method significantly improves the performance of image generation technique in terms of Frechet inception distance (FID) and Inception score (IS)., Comment: 13 pages, 8 figures

Systemic therapy of Gram-negative sepsis remains challenging. Polymyxin B (PMB) is well suited for sepsis therapy due to the endotoxin affinity and antibacterial activity. However, the dose-limiting toxicity has limited its systemic use in sepsis patients. For safe systemic use of PMB, we have developed a nanoparticulate system, called D-TZP, which selectively reduces the toxicity to mammalian cells but retains the therapeutic activities of PMB. D-TZP consists of an iron-complexed tannic acid nanocapsule containing a vitamin D core, coated with PMB and a chitosan derivative that controls the interaction of PMB with endotoxin, bacteria, and host cells. D-TZP attenuated the membrane toxicity associated with PMB but retained the ability of PMB to inactivate endotoxin and kill Gram-negative bacteria. Upon intravenous injection, D-TZP protected animals from pre-established endotoxemia and polymicrobial sepsis, showing no systemic toxicities inherent to PMB. These results support D-TZP as a safe and effective systemic intervention of sepsis.

Systemic therapy of Gram-negative sepsis remains challenging. Polymyxin B (PMB) is well suited for sepsis therapy due to the endotoxin affinity and antibacterial activity. However, the dose-limiting toxicity has limited its systemic use in sepsis patients. For safe systemic use of PMB, we have developed a nanoparticulate system, called D-TZP, which selectively reduces the toxicity to mammalian cells but retains the therapeutic activities of PMB. D-TZP consists of an iron-complexed tannic acid nanocapsule containing a vitamin D core, coated with PMB and a chitosan derivative that controls the interaction of PMB with endotoxin, bacteria, and host cells. D-TZP attenuated the membrane toxicity associated with PMB but retained the ability of PMB to inactivate endotoxin and kill Gram-negative bacteria. Upon intravenous injection, D-TZP protected animals from pre-established endotoxemia and polymicrobial sepsis, showing no systemic toxicities inherent to PMB. These results support D-TZP as a safe and effective systemic intervention of sepsis.

Convolutional neural networks (CNNs) have been not only widespread but also achieved noticeable results on numerous applications including image classification, restoration, and generation. Although the weight-sharing property of convolutions makes them widely adopted in various tasks, its content-agnostic characteristic can also be considered a major drawback. To solve this problem, in this paper, we propose a novel operation, called pixel adaptive kernel attention (PAKA). PAKA provides directivity to the filter weights by multiplying spatially varying attention from learnable features. The proposed method infers pixel-adaptive attention maps along the channel and spatial directions separately to address the decomposed model with fewer parameters. Our method is trainable in an end-to-end manner and applicable to any CNN-based models. In addition, we propose an improved information aggregation module with PAKA, called the hierarchical PAKA module (HPM). We demonstrate the superiority of our HPM by presenting state-of-the-art performance on semantic segmentation compared to the conventional information aggregation modules. We validate the proposed method through additional ablation studies and visualizing the effect of PAKA providing directivity to the weights of convolutions. We also show the generalizability of the proposed method by applying it to multi-modal tasks especially color-guided depth map super-resolution.

This paper presents a novel convolutional layer, called perturbed convolution (PConv), which focuses on achieving two goals simultaneously: improving the generative adversarial network (GAN) performance and alleviating the memorization problem in which the discriminator memorizes all images from a given dataset as training progresses. In PConv, perturbed features are generated by randomly disturbing an input tensor before performing the convolution operation. This approach is simple but surprisingly effective. First, to produce a similar output even with the perturbed tensor, each layer in the discriminator should learn robust features having a small local Lipschitz value. Second, since the input tensor is randomly perturbed during the training procedure like the dropout in neural networks, the memorization problem could be alleviated. To show the generalization ability of the proposed method, we conducted extensive experiments with various loss functions and datasets including CIFAR-10, CelebA, CelebA-HQ, LSUN, and tiny-ImageNet. The quantitative evaluations demonstrate that PConv effectively boosts the performance of GAN and conditional GAN in terms of Frechet inception distance (FID)., Comment: Submitted to journal, arXiv admin note: text overlap with arXiv:1911.10979

By harnessing pre-trained language models, summarization models had rapid progress recently. However, the models are mainly assessed by automatic evaluation metrics such as ROUGE. Although ROUGE is known for having a positive correlation with human evaluation scores, it has been criticized for its vulnerability and the gap between actual qualities. In this paper, we compare the generated summaries from recent LM, BART, and the reference summaries from a benchmark dataset, CNN/DM, using a crowd-sourced human evaluation metric. Interestingly, model-generated summaries receive higher scores relative to reference summaries. Stemming from our experimental results, we first argue the intrinsic characteristics of the CNN/DM dataset, the progress of pre-trained language models, and their ability to generalize on the training data. Finally, we share our insights into the model-generated summaries and presents our thought on learning methods for abstractive summarization., Comment: The initial version of the manuscript includes a model design (semsim), experimental results, and discussions on the results. We found that our model has flaws in its implementation and design. This final version of the manuscript is from the rest of the initial paper; we included our findings on the benchmark dataset, BART generated results and human evaluations, and we excluded our model semsim

In adversarial learning, discriminator often fails to guide the generator successfully since it distinguishes between real and generated images using silly or non-robust features. To alleviate this problem, this brief presents a simple but effective way that improves the performance of generative adversarial network (GAN) without imposing the training overhead or modifying the network architectures of existing methods. The proposed method employs a novel cascading rejection (CR) module for discriminator, which extracts multiple non-overlapped features in an iterative manner using the vector rejection operation. Since the extracted diverse features prevent the discriminator from concentrating on non-meaningful features, the discriminator can guide the generator effectively to produce the images that are more similar to the real images. In addition, since the proposed CR module requires only a few simple vector operations, it can be readily applied to existing frameworks with marginal training overheads. Quantitative evaluations on various datasets including CIFAR-10, CelebA, CelebA-HQ, LSUN, and tiny-ImageNet confirm that the proposed method significantly improves the performance of GAN and conditional GAN in terms of Frechet inception distance (FID) indicating the diversity and visual appearance of the generated images., Comment: Accepted to IEEE transactions on neural networks and learning systems

Conditional generative adversarial networks (cGANs) have been widely researched to generate class conditional images using a single generator. However, in the conventional cGANs techniques, it is still challenging for the generator to learn condition-specific features, since a standard convolutional layer with the same weights is used regardless of the condition. In this paper, we propose a novel convolution layer, called the conditional convolution layer, which directly generates different feature maps by employing the weights which are adjusted depending on the conditions. More specifically, in each conditional convolution layer, the weights are conditioned in a simple but effective way through filter-wise scaling and channel-wise shifting operations. In contrast to the conventional methods, the proposed method with a single generator can effectively handle condition-specific characteristics. The experimental results on CIFAR, LSUN and ImageNet datasets show that the generator with the proposed conditional convolution layer achieves a higher quality of conditional image generation than that with the standard convolution layer., Comment: Submitted to IEEE Trans. Neural Networks and Learning Systems (TNNLS)

Among the various generative adversarial network (GAN)-based image inpainting methods, a coarse-to-fine network with a contextual attention module (CAM) has shown remarkable performance. However, owing to two stacked generative networks, the coarse-to-fine network needs numerous computational resources such as convolution operations and network parameters, which result in low speed. To address this problem, we propose a novel network architecture called PEPSI: parallel extended-decoder path for semantic inpainting network, which aims at reducing the hardware costs and improving the inpainting performance. PEPSI consists of a single shared encoding network and parallel decoding networks called coarse and inpainting paths. The coarse path produces a preliminary inpainting result to train the encoding network for the prediction of features for the CAM. Simultaneously, the inpainting path generates higher inpainting quality using the refined features reconstructed via the CAM. In addition, we propose Diet-PEPSI that significantly reduces the network parameters while maintaining the performance. In Diet-PEPSI, to capture the global contextual information with low hardware costs, we propose novel rate-adaptive dilated convolutional layers, which employ the common weights but produce dynamic features depending on the given dilation rates. Extensive experiments comparing the performance with state-of-the-art image inpainting methods demonstrate that both PEPSI and Diet-PEPSI improve the qualitative scores, i.e. the peak signal-to-noise ratio (PSNR) and structural similarity (SSIM), as well as significantly reduce hardware costs such as computational time and the number of network parameters., Comment: Accepted to IEEE transactions on Neural Networks and Learning Systems. To be published

Various power-constrained contrast enhancement (PCCE) techniques have been applied to an organic light emitting diode (OLED) display for reducing the power demands of the display while preserving the image quality. In this paper, we propose a new deep learning-based PCCE scheme that constrains the power consumption of the OLED displays while enhancing the contrast of the displayed image. In the proposed method, the power consumption is constrained by simply reducing the brightness a certain ratio, whereas the perceived visual quality is preserved as much as possible by enhancing the contrast of the image using a convolutional neural network (CNN). Furthermore, our CNN can learn the PCCE technique without a reference image by unsupervised learning. Experimental results show that the proposed method is superior to conventional ones in terms of image quality assessment metrics such as a visual saliency-induced index (VSI) and a measure of enhancement (EME)., Comment: Accepted to IEEE transactions on Image Processing. To be published

Chitosan is a cationic polymer of natural origin and has been widely explored as a pharmaceutical excipient for a broad range of biomedical applications. While generally considered safe and biocompatible, chitosan has the ability to induce inflammatory reactions, which varies with the physical and chemical properties. We hypothesized that the previously reported zwitterionic chitosan (ZWC) derivative had relatively low pro-inflammatory potential because of the aqueous solubility and reduced amine content. To test this, we compared various chitosans with different aqueous solubilities or primary amine contents with respect to the intraperitoneal (IP) biocompatibility and the propensity to induce proinflammatory cytokine production from macrophages. ZWC was relatively well tolerated in ICR mice after IP administration and had no pro-inflammatory effect on naı¨ve macrophages. Comparison with other chitosans indicates that these properties are mainly due to the aqueous solubility at neutral pH and relatively low molecular weight of ZWC. Interestingly, ZWC had a unique ability to suppress cytokine/chemokine production in macrophages challenged with lipopolysaccharide (LPS). This effect is likely due to the strong affinity of ZWC to LPS, which inactivates the pro-inflammatory function of LPS, and appears to be related to the reduced amine content. Our finding warrants further investigation of ZWC as a functional biomaterial.

Chitosan is a cationic polymer of natural origin and has been widely explored as a pharmaceutical excipient for a broad range of biomedical applications. While generally considered safe and biocompatible, chitosan has the ability to induce inflammatory reactions, which varies with the physical and chemical properties. We hypothesized that the previously reported zwitterionic chitosan (ZWC) derivative had relatively low pro-inflammatory potential because of the aqueous solubility and reduced amine content. To test this, we compared various chitosans with different aqueous solubilities or primary amine contents with respect to the intraperitoneal (IP) biocompatibility and the propensity to induce proinflammatory cytokine production from macrophages. ZWC was relatively well tolerated in ICR mice after IP administration and had no pro-inflammatory effect on naı¨ve macrophages. Comparison with other chitosans indicates that these properties are mainly due to the aqueous solubility at neutral pH and relatively low molecular weight of ZWC. Interestingly, ZWC had a unique ability to suppress cytokine/chemokine production in macrophages challenged with lipopolysaccharide (LPS). This effect is likely due to the strong affinity of ZWC to LPS, which inactivates the pro-inflammatory function of LPS, and appears to be related to the reduced amine content. Our finding warrants further investigation of ZWC as a functional biomaterial.

Chitosan is a cationic polymer of natural origin and has been widely explored as a pharmaceutical excipient for a broad range of biomedical applications. While generally considered safe and biocompatible, chitosan has the ability to induce inflammatory reactions, which varies with the physical and chemical properties. We hypothesized that the previously reported zwitterionic chitosan (ZWC) derivative had relatively low pro-inflammatory potential because of the aqueous solubility and reduced amine content. To test this, we compared various chitosans with different aqueous solubilities or primary amine contents with respect to the intraperitoneal (IP) biocompatibility and the propensity to induce proinflammatory cytokine production from macrophages. ZWC was relatively well tolerated in ICR mice after IP administration and had no pro-inflammatory effect on naı¨ve macrophages. Comparison with other chitosans indicates that these properties are mainly due to the aqueous solubility at neutral pH and relatively low molecular weight of ZWC. Interestingly, ZWC had a unique ability to suppress cytokine/chemokine production in macrophages challenged with lipopolysaccharide (LPS). This effect is likely due to the strong affinity of ZWC to LPS, which inactivates the pro-inflammatory function of LPS, and appears to be related to the reduced amine content. Our finding warrants further investigation of ZWC as a functional biomaterial.

Chitosan is a cationic polymer of natural origin and has been widely explored as a pharmaceutical excipient for a broad range of biomedical applications. While generally considered safe and biocompatible, chitosan has the ability to induce inflammatory reactions, which varies with the physical and chemical properties. We hypothesized that the previously reported zwitterionic chitosan (ZWC) derivative had relatively low pro-inflammatory potential because of the aqueous solubility and reduced amine content. To test this, we compared various chitosans with different aqueous solubilities or primary amine contents with respect to the intraperitoneal (IP) biocompatibility and the propensity to induce proinflammatory cytokine production from macrophages. ZWC was relatively well tolerated in ICR mice after IP administration and had no pro-inflammatory effect on naı¨ve macrophages. Comparison with other chitosans indicates that these properties are mainly due to the aqueous solubility at neutral pH and relatively low molecular weight of ZWC. Interestingly, ZWC had a unique ability to suppress cytokine/chemokine production in macrophages challenged with lipopolysaccharide (LPS). This effect is likely due to the strong affinity of ZWC to LPS, which inactivates the pro-inflammatory function of LPS, and appears to be related to the reduced amine content. Our finding warrants further investigation of ZWC as a functional biomaterial.