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関節鏡視下手術は, 関節切開下の手術に比べて低侵襲であり, 術後の回復が早く疼痛が少ない, 術野や組織が拡大されるため正確で精密な処置が可能, と行った利点があり, 人体のほぼすべての関節の疾患に対して広く行われるようになっている. 特に膝関節・足関節を中心とするスポーツに関連した外傷/障害の治療に対して, 関節鏡なくしては手術治療が成立しない. 今後の課題として, 特に若手医師のトレーニンングをどのようにしてすすめるか, 術中ナビゲーションの応用, 生物学的治癒の促進をはかる方法の開発, などがあり, これらの進歩をふまえてさらに適応が拡大されて行く可能性を秘めている.

Pycnodysostosis (PKND) is a type of osteosclerosing bone disease. Recent studies have demonstrated that several cathepsin K mutations can be identified in PKND families. A fifty-three-year-old Japanese woman diagnosed with PKND with typical features suffered from the nonunion of the right tibial shaft. We did open reduction and performed a vascularized fibular graft using an external fixator. A low-intensity pulsed ultrasound device was used three months after surgery. Union of the tibia was completed about one year after surgery. Histomorphometric analysis of the iliac bone revealed that the patient had low turnover bone with increased bone volume. Analysis of the cathepsin K coding region from the genomic DNA of the patient and her family (consanguineous parents and three sisters who were all of normal stature) revealed that the patient had a deletion of genomic DNA nucleotide 426 T in exon 5. Her parents and two sisters had a heterozygous mutation, while one sister had a normal sequence. In summary, a mutation in the cathepsin K gene was identified, providing further evidence that a deficiency in the activity of this enzyme causes PKND., departmental bulletin paper

type:text, The distribution of G cells in mucosa of the resected stomachs from patients with peptic ulcer was investigated using the peroxidase-antiperoxidase immunohistochemical method. Moreover, the specimens were stained additionally with hematoxylin and eosin to determine the condition of background gastric mucosa. G cells were present chiefly in the glandular cervix of the pyloric gland area. They were also seen in the intermediate area and, although small in number, in the area adjoining the f-line. The number of G cells per unit area in DU was three times higher than that in GU. The significant inverse relation was found between G cell density and the degree of intestinal metaplasia. And in each case, mean values of uG were estimated for unit areas on the greater and lesser curvature lines as well as the unit areas on the mid-line of the anterior and posterior walls. The G cell density was higher on the greater curvature and in the posterior wall than the other.

The distribution of G cells in mucosa of the resected stomachs from patients with peptic ulcer was investigated using the peroxidase-antiperoxidase immunohistochemical method. Moreover, the specimens were stained additionally with hematoxylin and eosin to determine the condition of background gastric mucosa. G cells were present chiefly in the glandular cervix of the pyloric gland area. They were also seen in the intermediate area and, although small in number, in the area adjoining the f-line. The number of G cells per unit area in DU was three times higher than that in GU. The significant inverse relation was found between G cell density and the degree of intestinal metaplasia. And in each case, mean values of uG were estimated for unit areas on the greater and lesser curvature lines as well as the unit areas on the mid-line of the anterior and posterior walls. The G cell density was higher on the greater curvature and in the posterior wall than the other.

The distribution of G cells in mucosa of the resected stomachs from patients with peptic ulcer was investigated using the peroxidase-antiperoxidase immunohistochemical method. Moreover, the specimens were stained additionally with hematoxylin and eosin to determine the condition of background gastric mucosa. G cells were present chiefly in the glandular cervix of the pyloric gland area. They were also seen in the intermediate area and, although small in number, in the area adjoining the f-line. The number of G cells per unit area in DU was three times higher than that in GU. The significant inverse relation was found between G cell density and the degree of intestinal metaplasia. And in each case, mean values of uG were estimated for unit areas on the greater and lesser curvature lines as well as the unit areas on the mid-line of the anterior and posterior walls. The G cell density was higher on the greater curvature and in the posterior wall than the other.

The distribution of G cells in mucosa of the resected stomachs from patients with peptic ulcer was investigated using the peroxidase-antiperoxidase immunohistochemical method. Moreover, the specimens were stained additionally with hematoxylin and eosin to determine the condition of background gastric mucosa. G cells were present chiefly in the glandular cervix of the pyloric gland area. They were also seen in the intermediate area and, although small in number, in the area adjoining the f-line. The number of G cells per unit area in DU was three times higher than that in GU. The significant inverse relation was found between G cell density and the degree of intestinal metaplasia. And in each case, mean values of uG were estimated for unit areas on the greater and lesser curvature lines as well as the unit areas on the mid-line of the anterior and posterior walls. The G cell density was higher on the greater curvature and in the posterior wall than the other.