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Yachen Ji,* Xiangjun Xu,* Kangfei Wu, Yi Sun, Hao Wang, Yapeng Guo, Ke Yang, Junfeng Xu, Qian Yang, Xianjun Huang, Zhiming Zhou Department of Neurology, The First Affiliated Hospital of Wannan Medical College, Wuhu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xianjun Huang; Zhiming Zhou, Department of Neurology, The First Affiliated Hospital of Wannan Medical College, 2# East Zheshan Road, Wuhu, 241000, People’s Republic of China, Tel +86-25-80860124, Fax +86-25-84664563, Email doctorhuangxj@hotmail.Com; neuro_depar@hotmail.ComPurpose: The systemic immune inflammatory index (SII), as a new marker, is widely used to predict the disease prognosis. We investigated the predictive value of SII for malignant cerebral edema (MCE) and whether postoperative MCE mediates the relationship between SII and functional prognosis in patients undergoing endovascular thrombectomy (EVT).Patients and Methods: A total of 829 patients with anterior circulation large-vessel occlusive stroke (LVOS) were registered, and 675 (81.4%) met the inclusion criteria. We collected baseline data upon admission, including SII. Postoperative computed tomography was performed to assess the presence and grading of cerebral edema (CED), and MCE was defined as a CED score of 3. A good prognosis was defined as a modified Rankin Scale (mRS) score of 0– 2 at the 90-day follow-up.Results: A total of 132 patients developed MCE after EVT. The patients were divided into MCE and non-MCE groups, and univariate and multifactorial analyses were performed. Among these risk factors, an elevated SII was independently correlated with the occurrence of MCE. In addition, the receiver operating characteristic (ROC) curve was used to assess the predictive capability of SII levels for prognosis. The area under the ROC was 0.69, and the optimal critical value was 2.14. In addition, postoperative MCE may partially account for the poorer functional progno

Lili Yuan,&ast; Yi Sun,&ast; Xianjun Huang, Xiangjun Xu, Junfeng Xu, Youqing Xu, Qian Yang, Yujuan Zhu, Zhiming Zhou Department of Neurology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yujuan Zhu; Zhiming Zhou, Department of Neurology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui Province, 241000, People’s Republic of China, Email ajuan3975@163.com; neuro_depar@hotmail.comObjective: We aimed to analyze the association between fasting blood-glucose (FBG) level and 3-month functional outcome in anterior circulation ischemic stroke in different age groups after endovascular treatment (EVT).Methods: We retrospectively analyzed the consecutive patients with acute ischemic stroke (AIS) receiving EVT from our department between July 2015 and March 2021. The patients were categorized into the older (≥ 60 years) and younger (< 60 years) groups, and patients in each age group were dichotomized into favorable versus unfavorable outcomes according to the 3-month modified Rankin Scale (mRS) score.Results: A total of 504 patients (286 males and 218 females) were included in our study. Three hundred ninety-two patients (77.8%) belonged to the group aged ≥ 60 years, and 112 (22.2%) belonged to the group aged < 60 years. At the end of the study, 222 (56.6%) patients developed unfavorable outcomes in the older group and 31 (27.7%) showed unfavorable outcomes in the younger group. FBG level of the younger patients was significantly lower than that of older patients. In the older group, FBG level independently predicted a 3-month clinical unfavorable outcome with an odds ratio of 1.242 (95% confidence interval, 1.096– 1.407; p = 0.001). However, the association was not found in the younger group (p = 0.376).Conclusion: Higher FBG level is an independent risk factor for 3-month unfavorable outcome in the AIS

Xiangjun Xu,* Lili Yuan,* Wenbing Wang,* Junfeng Xu, Qian Yang, Yujuan Zhu, Youqing Xu, Ke Yang, Liang Ge, Xianjun Huang, Zhiming Zhou Department of Neurology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhiming Zhou; Xianjun HuangDepartment of Neurology, The First Affiliated Hospital of Wannan Medical College, 2# East Zheshan Road, Wuhu 241000 Anhui Province, People’s Republic of ChinaTel +86-25-80860124Fax +86-25-84664563Email neuro_depar@hotmail.com; doctorhuangxj@hotmail.comPurpose: Knowledge regarding the systemic inflammatory response syndrome (SIRS) associated with emergent large vessel occlusion (ELVO) is still insufficient. We aimed to investigate the occurrence rate, predictors, and clinical outcomes of SIRS in patients with ELVO after endovascular treatment (EVT).Patients and Methods: We retrospectively collected EVT data of patients with ELVO from July 2015 to August 2019 in our center. SIRS in the absence of infection was recorded in detail. A favorable outcome was defined as obtaining a 90-day modified Rankin Scale (mRS) score ≤ 2.Results: Among the 256 patients who received EVT, 91 (35.5%) developed SIRS. The patients who developed SIRS had a reduced favorable outcome (OR 4.112 [95% CI 1.705 to 9.920]; p=0.002) and higher mortality (OR 25.336 [95% CI 8.578 to 74.835]; p< 0.001) at 90 days. A greater SIRS burden was positively correlated with the NIHSS scores at discharge and mRS scores at 90 days (r=0.265, p=0.011; r=0.245, p=0.019). The development of SIRS was associated with neutrophilic leukocytosis, hyperglycemia, higher NIHSS scores at admission, and worse collateral circulation.Conclusion: The patients with SIRS had higher odds of poor functional outcomes and higher mortality at 90 days in the EVT-treatment setting. The severity of the inflammatory response was positively correlated with th

Lili Yuan,1,* Yuanxiang Zhang,2,* Di Luan,1 Xiangjun Xu,1 Qian Yang,1 Shoucai Zhao,1 Zhiming Zhou1 1Department of Neurology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui Province, People’s Republic of China; 2Department of Clinical Pharmacy, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lili YuanDepartment of Neurology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui Province 241000, People’s Republic of ChinaEmail molly8338@126.comIntroduction: Affective symptoms and attention impairments are found in patients with hyperthyroidism. Our previous data have revealed that the patients with hyperthyroidism experience impairments of the attention networks, but it remains unclear whether these disorders persist after the treatment of hyperthyroidism.Methods: Twenty healthy controls and 25 hyperthyroid patients were recruited and performed the attention network test (ANT) which can simultaneously examine the alertness, orientation and execution control components of the participants. The effect of treatment on affective symptom and attention networks impairments were examined in the patient group after 1-year anti-thyroid medication and reaching euthyroidism for at least 3 months.Results: Anxiety and depression scores of patients with hyperthyroidism were significantly higher than those of the healthy control group. The patients with hyperthyroidism had impairments of the alerting and executive control networks. Meanwhile, the score of HAMA correlated significantly with thyroid hormone and TSH levels, and there was a negative significant correlation between the score of HAMD and TSH level in all subjects. There was a positive correlation between the value of the executive control network and thyroid hormones’ levels in all subjects and in the hyperthyroidism group. Anxi

BACKGROUND/AIMS: Podocytes have a unique function in the renal ultrafiltration that is achieved by expressing proteins that are highly specific to podocytes. In this study, we identified two novel podocyte-associated proteins. METHODS: The expression of sult1b1 and ankrd25 in mouse tissues was studied by RT-PCR. The protein expression was studied by generating polyclonal antibodies that were used in Western blotting and immunohistochemistry. RESULTS: By RT-PCR we detected sult1b1 expression only in glomerular, liver and brain tissues. By immunohistochemistry, sult1b1 was detected in the kidney exclusively in the Golgi apparatus of the podocyte. No expression outside the glomerulus was observed in the kidney. The ankrd25 transcript was detected in most mouse tissues analyzed by RT-PCR. In the kidney, however, immunohistochemistry showed that this protein was expressed only by podocyte, mesangial, and smooth muscle cells. In podocytes, ankrd25 was localized to foot processes. CONCLUSIONS: Identification of these two novel glomerulus-associated proteins opens up possibilities to investigate their role in the renal filter physiology and diseases. We speculate that sult1b1 may be involved in the sulfonylation of podocyte protein podocalyxin, whereas ankrd25 may contribute to controlling actin dynamics in podocyte foot processes., QC 20111215