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4 results on '"Wright MW"'

1. RNAcentral: An international database of ncRNA sequences

Author

Petrov, AI, Kay, SJE, Gibson, R, Kulesha, E, Staines, D, Bruford, EA, Wright, MW, Burge, S, Finn, RD, Kersey, PJ, Cochrane, G, Bateman, A, Griffiths-Jones, S, Harrow, J, Chan, PP, Lowe, TM, Zwieb, CW, Wower, J, Williams, KP, Hudson, CM, Gutell, R, Clark, MB, Dinger, M, Quek, XC, Bujnicki, JM, Chua, NH, Liu, J, Wang, H, Skogerbø, G, Zhao, Y, Chen, R, Zhu, W, Cole, JR, Chai, B, Huang, HD, Huang, HY, Cherry, JM, Hatzigeorgiou, A, Pruitt, KD, Petrov, AI, Kay, SJE, Gibson, R, Kulesha, E, Staines, D, Bruford, EA, Wright, MW, Burge, S, Finn, RD, Kersey, PJ, Cochrane, G, Bateman, A, Griffiths-Jones, S, Harrow, J, Chan, PP, Lowe, TM, Zwieb, CW, Wower, J, Williams, KP, Hudson, CM, Gutell, R, Clark, MB, Dinger, M, Quek, XC, Bujnicki, JM, Chua, NH, Liu, J, Wang, H, Skogerbø, G, Zhao, Y, Chen, R, Zhu, W, Cole, JR, Chai, B, Huang, HD, Huang, HY, Cherry, JM, Hatzigeorgiou, A, and Pruitt, KD

Abstract

The field of non-coding RNA biology has been hampered by the lack of availability of a comprehensive, up-to-date collection of accessioned RNA sequences. Here we present the first release of RNA-central, a database that collates and integrates information from an international consortium of established RNA sequence databases. The initial release contains over 8.1 million sequences, including representatives of all major functional classes. A web portal (http://rnacentral.org) provides free access to data, search functionality, cross-references, source code and an integrated genome browser for selected species.

Published
2015

2. RNAcentral: an international database of ncRNA sequences

Author

Petrov, AI, Kay, SJE, Gibson, R, Kulesha, E, Staines, D, Bruford, EA, Wright, MW, Burge, S, Finn, RD, Kersey, PJ, Cochrane, G, Bateman, A, Griffiths-Jones, S, Harrow, J, Chan, PP, Lowe, TM, Zwieb, CW, Wower, J, Williams, KP, Hudson, CM, Gutell, R, Clark, MB, Dinger, M, Quek, XC, Bujnicki, JM, Chua, N-H, Liu, J, Wang, H, Skogerbo, G, Zhao, Y, Chen, R, Zhu, W, Cole, JR, Chai, B, Huang, H-D, Huang, H-Y, Cherry, JM, Hatzigeorgiou, A, Pruitt, KD, Petrov, AI, Kay, SJE, Gibson, R, Kulesha, E, Staines, D, Bruford, EA, Wright, MW, Burge, S, Finn, RD, Kersey, PJ, Cochrane, G, Bateman, A, Griffiths-Jones, S, Harrow, J, Chan, PP, Lowe, TM, Zwieb, CW, Wower, J, Williams, KP, Hudson, CM, Gutell, R, Clark, MB, Dinger, M, Quek, XC, Bujnicki, JM, Chua, N-H, Liu, J, Wang, H, Skogerbo, G, Zhao, Y, Chen, R, Zhu, W, Cole, JR, Chai, B, Huang, H-D, Huang, H-Y, Cherry, JM, Hatzigeorgiou, A, and Pruitt, KD

Abstract

The field of non-coding RNA biology has been hampered by the lack of availability of a comprehensive, up-to-date collection of accessioned RNA sequences. Here we present the first release of RNAcentral, a database that collates and integrates information from an international consortium of established RNA sequence databases. The initial release contains over 8.1 million sequences, including representatives of all major functional classes. A web portal (http://rnacentral.org) provides free access to data, search functionality, cross-references, source code and an integrated genome browser for selected species.

Published
2015

3. Update of the human and mouse SERPIN gene superfamily

Author

Heit, C, Jackson, BC, McAndrews, M, Wright, MW, Thompson, DC, Silverman, GA, Nebert, DW, Vasiliou, V, Heit, C, Jackson, BC, McAndrews, M, Wright, MW, Thompson, DC, Silverman, GA, Nebert, DW, and Vasiliou, V

Abstract

The serpin family comprises a structurally similar, yet functionally diverse, set of proteins. Named originally for their function as serine proteinase inhibitors, many of its members are not inhibitors but rather chaperones, involved in storage, transport, and other roles. Serpins are found in genomes of all kingdoms, with 36 human protein-coding genes and five pseudogenes. The mouse has 60 Serpin functional genes, many of which are orthologous to human SERPIN genes and some of which have expanded into multiple paralogous genes. Serpins are found in tissues throughout the body; whereas most are extracellular, there is a class of intracellular serpins. Serpins appear to have roles in inflammation, immune function, tumorigenesis, blood clotting, dementia, and cancer metastasis. Further characterization of these proteins will likely reveal potential biomarkers and therapeutic targets for disease. © 2013 Heit et al.

Published
2013

4. Update of the human and mouse SERPIN gene superfamily

Author

Heit, C, Jackson, BC, McAndrews, M, Wright, MW, Thompson, DC, Silverman, GA, Nebert, DW, Vasiliou, V, Heit, C, Jackson, BC, McAndrews, M, Wright, MW, Thompson, DC, Silverman, GA, Nebert, DW, and Vasiliou, V

Abstract

The serpin family comprises a structurally similar, yet functionally diverse, set of proteins. Named originally for their function as serine proteinase inhibitors, many of its members are not inhibitors but rather chaperones, involved in storage, transport, and other roles. Serpins are found in genomes of all kingdoms, with 36 human protein-coding genes and five pseudogenes. The mouse has 60 Serpin functional genes, many of which are orthologous to human SERPIN genes and some of which have expanded into multiple paralogous genes. Serpins are found in tissues throughout the body; whereas most are extracellular, there is a class of intracellular serpins. Serpins appear to have roles in inflammation, immune function, tumorigenesis, blood clotting, dementia, and cancer metastasis. Further characterization of these proteins will likely reveal potential biomarkers and therapeutic targets for disease. © 2013 Heit et al.

Published
2013

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