Search

Your search keyword '"Wiertz, Emmanuel"' showing total 122 results
Start Over Author "Wiertz, Emmanuel" Database OAIster
122 results on '"Wiertz, Emmanuel"'

2. CRISPR/Cas9-mediated genome editing of the thymidine kinase gene in a clinical HSV-1 isolate identifies F289S as novel acyclovir-resistant mutation

Author

MMB Research line 3a, Infection & Immunity, Zheng, Shuxuan, Verjans, Georges M.G.M., Evers, Anouk, van den Wittenboer, Ellen, Tjhie, Jeroen H.T., Snoeck, Robert, Wiertz, Emmanuel J.H.J., Andrei, Graciela, van Kampen, Jeroen J.A., Lebbink, Robert Jan, MMB Research line 3a, Infection & Immunity, Zheng, Shuxuan, Verjans, Georges M.G.M., Evers, Anouk, van den Wittenboer, Ellen, Tjhie, Jeroen H.T., Snoeck, Robert, Wiertz, Emmanuel J.H.J., Andrei, Graciela, van Kampen, Jeroen J.A., and Lebbink, Robert Jan

Published
2024

3. Proinsulin degradation and presentation of a proinsulin B-chain autoantigen involves ER-associated protein degradation (ERAD)-enzyme UBE2G2

Author

MMB Research line 3a, Infection & Immunity, Cremer, Tom, Hoelen, Hanneke, van de Weijer, Michael L, Janssen, George M, Costa, Ana I, van Veelen, Peter A, Lebbink, Robert Jan, Wiertz, Emmanuel J H J, MMB Research line 3a, Infection & Immunity, Cremer, Tom, Hoelen, Hanneke, van de Weijer, Michael L, Janssen, George M, Costa, Ana I, van Veelen, Peter A, Lebbink, Robert Jan, and Wiertz, Emmanuel J H J

Published
2024

4. CRISPR/Cas9-mediated genome editing of the thymidine kinase gene in a clinical HSV-1 isolate identifies F289S as novel acyclovir-resistant mutation

Author

Zheng, Shuxuan, Verjans, Georges M.G.M., Evers, Anouk, van den Wittenboer, Ellen, Tjhie, Jeroen H.T., Snoeck, Robert, Wiertz, Emmanuel J.H.J., Andrei, Graciela, van Kampen, Jeroen J.A., Lebbink, Robert Jan, Zheng, Shuxuan, Verjans, Georges M.G.M., Evers, Anouk, van den Wittenboer, Ellen, Tjhie, Jeroen H.T., Snoeck, Robert, Wiertz, Emmanuel J.H.J., Andrei, Graciela, van Kampen, Jeroen J.A., and Lebbink, Robert Jan

Abstract

Herpes simplex virus type 1 (HSV-1) is a neurotropic alphaherpesvirus that establishes a lifelong infection in sensory neurons of infected individuals, accompanied with intermittent reactivation of latent virus causing (a)symptomatic virus shedding. Whereas acyclovir (ACV) is a safe and highly effective antiviral to treat HSV-1 infections, long-term usage can lead to emergence of ACV resistant (ACVR) HSV-1 and subsequently ACV refractory disease. Here, we isolated an HSV-1 strain from a patient with reactivated herpetic eye disease that did not respond to ACV treatment. The isolate carried a novel non-synonymous F289S mutation in the viral UL23 gene encoding the thymidine kinase (TK) protein. Because ACV needs conversion by viral TK and subsequently cellular kinases to inhibit HSV-1 replication, the UL23 gene is commonly mutated in ACVR HSV-1 strains. The potential role of the F289S mutation causing ACVR was investigated using CRISPR/Cas9-mediated HSV-1 genome editing. Reverting the F289S mutation in the original clinical isolate to the wild-type sequence S289F resulted in an ACV-sensitive (ACVS) phenotype, and introduction of the F289S substitution in an ACVS HSV-1 reference strain led to an ACVR phenotype. In summary, we identified a new HSV-1 TK mutation in the eye of a patient with ACV refractory herpetic eye disease, which was identified as the causative ACVR mutation with the aid of CRISPR/Cas9-mediated genome engineering technology. Direct editing of clinical HSV-1 isolates by CRISPR/Cas9 is a powerful strategy to assess whether single residue substitutions are causative to a clinical ACVR phenotype.

Published
2024

5. Enhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease cathepsin S

Author

MMB Research line 3a, Infection & Immunity, Harryvan, Tom J., Visser, Marten, De Bruin, Linda, Plug, Léonie, Griffioen, Lisa, Mulder, Arend, Van Veelen, Peter A., Van Der Heden Van Noort, Gerbrand J., Jongsma, Marlieke L.M., Meeuwsen, Miranda H., Wiertz, Emmanuel J.H.J., Santegoets, Saskia J., Hardwick, James C.H., Van Hall, Thorbald, Neefjes, Jacques, Van Der Burg, Sjoerd H., Hawinkels, Lukas J.A.C., Verdegaal, Els M.E., MMB Research line 3a, Infection & Immunity, Harryvan, Tom J., Visser, Marten, De Bruin, Linda, Plug, Léonie, Griffioen, Lisa, Mulder, Arend, Van Veelen, Peter A., Van Der Heden Van Noort, Gerbrand J., Jongsma, Marlieke L.M., Meeuwsen, Miranda H., Wiertz, Emmanuel J.H.J., Santegoets, Saskia J., Hardwick, James C.H., Van Hall, Thorbald, Neefjes, Jacques, Van Der Burg, Sjoerd H., Hawinkels, Lukas J.A.C., and Verdegaal, Els M.E.

Published
2022

6. Construction of an African Swine Fever Virus phagemid library through non-homologues random recombination

Author

Heusden, Niels van, Wiertz, Emmanuel (Thesis Advisor), Heusden, Niels van, and Wiertz, Emmanuel (Thesis Advisor)

Abstract

African swine fever (ASF) is a haemorrhagic disease that affects swine in ongoing epidemics around the world. The etiologic agent of ASF, the African Swine Fever virus (ASFV), is a large multi-layered icosahedral dsDNA virus that encodes over 170 proteins, many of which have yet unknown functions. Partly because of its complexity, commercially available vaccines against ASF remain unavailable. Experimental attenuated-, subunit-, vector-, and DNA-vaccines have been developed previously, however, all fail to induce protective immunity outside of experimental conditions. Therefore, to aid the development of a multi-epitope chimeric vaccine against ASF, we attempted to construct a random multi-epitope library that can subsequently be screened for antigenic ASFV epitopes. To develop a randomized library of multi-epitope ASFV chimeras, gene fragment libraries were constructed using non-homologues recombination (NRR). Subsequently, we attempted to clone ASFV chimeras into phagemid vectors, to identify antigenic B-cell epitopes using phage-display. Although this study did not successfully recombine ASFV-derived epitope fragments, we offer valuable insight into the development of randomized DNA libraries. Our results demonstrate that NRR can be used for the construction of randomly recombined dsDNA libraries. Additionally, we identified conformational B-cell epitopes on the surface of ASFV chimeras using in silico prediction tools. In conclusion, further research should optimize these methods to generate a diverse randomized multi-epitope chimeric library. Any antigenic multi-epitope chimera that arises from such study could contribute to the development of a multi-epitope-based ASFV vaccine.

Published
2021

7. Construction of an African Swine Fever Virus phagemid library through non-homologues random recombination

Author

Heusden, Niels van, Wiertz, Emmanuel (Thesis Advisor), Heusden, Niels van, and Wiertz, Emmanuel (Thesis Advisor)

Abstract

African swine fever (ASF) is a haemorrhagic disease that affects swine in ongoing epidemics around the world. The etiologic agent of ASF, the African Swine Fever virus (ASFV), is a large multi-layered icosahedral dsDNA virus that encodes over 170 proteins, many of which have yet unknown functions. Partly because of its complexity, commercially available vaccines against ASF remain unavailable. Experimental attenuated-, subunit-, vector-, and DNA-vaccines have been developed previously, however, all fail to induce protective immunity outside of experimental conditions. Therefore, to aid the development of a multi-epitope chimeric vaccine against ASF, we attempted to construct a random multi-epitope library that can subsequently be screened for antigenic ASFV epitopes. To develop a randomized library of multi-epitope ASFV chimeras, gene fragment libraries were constructed using non-homologues recombination (NRR). Subsequently, we attempted to clone ASFV chimeras into phagemid vectors, to identify antigenic B-cell epitopes using phage-display. Although this study did not successfully recombine ASFV-derived epitope fragments, we offer valuable insight into the development of randomized DNA libraries. Our results demonstrate that NRR can be used for the construction of randomly recombined dsDNA libraries. Additionally, we identified conformational B-cell epitopes on the surface of ASFV chimeras using in silico prediction tools. In conclusion, further research should optimize these methods to generate a diverse randomized multi-epitope chimeric library. Any antigenic multi-epitope chimera that arises from such study could contribute to the development of a multi-epitope-based ASFV vaccine.

Published
2021

8. A class II MHC-targeted vaccine elicits immunity against SARS-CoV-2 and its variants

Author

MMB Research line 3a, Infection & Immunity, Pishesha, Novalia, Harmand, Thibault J, Rothlauf, Paul W, Praest, Patrique, Alexander, Ryan K, van den Doel, Renate, Liebeskind, Mariel J, Vakaki, Maria A, McCaul, Nicholas, Wijne, Charlotte, Verhaar, Elisha, Pinney, William, Heston, Hailey, Bloyet, Louis-Marie, Pontelli, Marjorie Cornejo, Ilagan, Ma Xenia G, Jan Lebbink, Robert, Buchser, William J, Wiertz, Emmanuel J H J, Whelan, Sean P J, Ploegh, Hidde L, MMB Research line 3a, Infection & Immunity, Pishesha, Novalia, Harmand, Thibault J, Rothlauf, Paul W, Praest, Patrique, Alexander, Ryan K, van den Doel, Renate, Liebeskind, Mariel J, Vakaki, Maria A, McCaul, Nicholas, Wijne, Charlotte, Verhaar, Elisha, Pinney, William, Heston, Hailey, Bloyet, Louis-Marie, Pontelli, Marjorie Cornejo, Ilagan, Ma Xenia G, Jan Lebbink, Robert, Buchser, William J, Wiertz, Emmanuel J H J, Whelan, Sean P J, and Ploegh, Hidde L

Published
2021

9. Signaling of a varicelloviral factor across the endoplasmic reticulum membrane induces destruction of the peptide-loading complex and immune evasion

Author

Loch, Sandra, Klauschies, Florian, Schölz, Christian, Verweij, Marieke C., Wiertz, Emmanuel J. H. J., Koch, Joachim, Tampé, Robert, Loch, Sandra, Klauschies, Florian, Schölz, Christian, Verweij, Marieke C., Wiertz, Emmanuel J. H. J., Koch, Joachim, and Tampé, Robert

Abstract

Cytotoxic T lymphocytes eliminate infected cells upon surface display of antigenic peptides on major histocompatibility complex I molecules. To promote immune evasion, UL49.5 of several varicelloviruses interferes with the pathway of major histocompatibility complex I antigen processing. However, the inhibition mechanism has not been elucidated yet. Within the macromolecular peptide-loading complex we identified the transporter associated with antigen processing (TAP1 and TAP2) as the prime target of UL49.5. Moreover, we determined the active oligomeric state and crucial elements of the viral factor. Remarkably, the last two residues of the cytosolic tail of UL49.5 are essential for endoplasmic reticulum (ER)-associated proteasomal degradation of TAP. However, this process strictly requires additional signaling of an upstream regulatory element in the ER lumenal domain of UL49.5. Within this new immune evasion mechanism, we show for the first time that additive elements of a small viral factor and their signaling across the ER membrane are essential for targeted degradation of a multi-subunit membrane complex.

Published
2021

10. A Broad-Spectrum Antiviral Peptide Blocks Infection of Viruses by Binding to Phosphatidylserine in the Viral Envelope

Author

Luteijn, Rutger D., Praest, Patrique, Thiele, Frank, Sadasivam, Saravanan Manikam, Singethan, Katrin, Drijfhout, Jan W., Bach, Christian, de Boer, Steffen Matthijn, Lebbink, Robert J., Tao, Sha, Helfer, Markus, Bach, Nina C., Protzer, Ulrike, Costa, Ana I., Killian, J. Antoinette, Drexler, Ingo, Wiertz, Emmanuel J.H.J., Luteijn, Rutger D., Praest, Patrique, Thiele, Frank, Sadasivam, Saravanan Manikam, Singethan, Katrin, Drijfhout, Jan W., Bach, Christian, de Boer, Steffen Matthijn, Lebbink, Robert J., Tao, Sha, Helfer, Markus, Bach, Nina C., Protzer, Ulrike, Costa, Ana I., Killian, J. Antoinette, Drexler, Ingo, and Wiertz, Emmanuel J.H.J.

Abstract

The ongoing threat of viral infections and the emergence of antiviral drug resistance warrants a ceaseless search for new antiviral compounds. Broadly-inhibiting compounds that act on elements shared by many viruses are promising antiviral candidates. Here, we identify a peptide derived from the cowpox virus protein CPXV012 as a broad-spectrum antiviral peptide. We found that CPXV012 peptide hampers infection by a multitude of clinically and economically important enveloped viruses, including poxviruses, herpes simplex virus-1, hepatitis B virus, HIV-1, and Rift Valley fever virus. Infections with non-enveloped viruses such as Coxsackie B3 virus and adenovirus are not affected. The results furthermore suggest that viral particles are neutralized by direct interactions with CPXV012 peptide and that this cationic peptide may specifically bind to and disrupt membranes composed of the anionic phospholipid phosphatidylserine, an important component of many viral membranes. The combined results strongly suggest that CPXV012 peptide inhibits virus infections by direct interactions with phosphatidylserine in the viral envelope. These results reiterate the potential of cationic peptides as broadly-acting virus inhibitors.

Published
2020

11. A Broad-Spectrum Antiviral Peptide Blocks Infection of Viruses by Binding to Phosphatidylserine in the Viral Envelope

Author

Virologie, Sub Membrane Biochemistry & Biophysics, LS Virologie, Membrane Biochemistry and Biophysics, Luteijn, Rutger D., Praest, Patrique, Thiele, Frank, Sadasivam, Saravanan Manikam, Singethan, Katrin, Drijfhout, Jan W., Bach, Christian, de Boer, Steffen Matthijn, Lebbink, Robert J., Tao, Sha, Helfer, Markus, Bach, Nina C., Protzer, Ulrike, Costa, Ana I., Killian, J. Antoinette, Drexler, Ingo, Wiertz, Emmanuel J.H.J., Virologie, Sub Membrane Biochemistry & Biophysics, LS Virologie, Membrane Biochemistry and Biophysics, Luteijn, Rutger D., Praest, Patrique, Thiele, Frank, Sadasivam, Saravanan Manikam, Singethan, Katrin, Drijfhout, Jan W., Bach, Christian, de Boer, Steffen Matthijn, Lebbink, Robert J., Tao, Sha, Helfer, Markus, Bach, Nina C., Protzer, Ulrike, Costa, Ana I., Killian, J. Antoinette, Drexler, Ingo, and Wiertz, Emmanuel J.H.J.

Published
2020

12. A Broad-Spectrum Antiviral Peptide Blocks Infection of Viruses by Binding to Phosphatidylserine in the Viral Envelope

Author

Virologie, Sub Membrane Biochemistry & Biophysics, LS Virologie, Membrane Biochemistry and Biophysics, Luteijn, Rutger D., Praest, Patrique, Thiele, Frank, Sadasivam, Saravanan Manikam, Singethan, Katrin, Drijfhout, Jan W., Bach, Christian, de Boer, Steffen Matthijn, Lebbink, Robert J., Tao, Sha, Helfer, Markus, Bach, Nina C., Protzer, Ulrike, Costa, Ana I., Killian, J. Antoinette, Drexler, Ingo, Wiertz, Emmanuel J.H.J., Virologie, Sub Membrane Biochemistry & Biophysics, LS Virologie, Membrane Biochemistry and Biophysics, Luteijn, Rutger D., Praest, Patrique, Thiele, Frank, Sadasivam, Saravanan Manikam, Singethan, Katrin, Drijfhout, Jan W., Bach, Christian, de Boer, Steffen Matthijn, Lebbink, Robert J., Tao, Sha, Helfer, Markus, Bach, Nina C., Protzer, Ulrike, Costa, Ana I., Killian, J. Antoinette, Drexler, Ingo, and Wiertz, Emmanuel J.H.J.

Published
2020

13. A Broad-Spectrum Antiviral Peptide Blocks Infection of Viruses by Binding to Phosphatidylserine in the Viral Envelope

Author

Virologie, Sub Membrane Biochemistry & Biophysics, LS Virologie, Membrane Biochemistry and Biophysics, Luteijn, Rutger D., Praest, Patrique, Thiele, Frank, Sadasivam, Saravanan Manikam, Singethan, Katrin, Drijfhout, Jan W., Bach, Christian, de Boer, Steffen Matthijn, Lebbink, Robert J., Tao, Sha, Helfer, Markus, Bach, Nina C., Protzer, Ulrike, Costa, Ana I., Killian, J. Antoinette, Drexler, Ingo, Wiertz, Emmanuel J.H.J., Virologie, Sub Membrane Biochemistry & Biophysics, LS Virologie, Membrane Biochemistry and Biophysics, Luteijn, Rutger D., Praest, Patrique, Thiele, Frank, Sadasivam, Saravanan Manikam, Singethan, Katrin, Drijfhout, Jan W., Bach, Christian, de Boer, Steffen Matthijn, Lebbink, Robert J., Tao, Sha, Helfer, Markus, Bach, Nina C., Protzer, Ulrike, Costa, Ana I., Killian, J. Antoinette, Drexler, Ingo, and Wiertz, Emmanuel J.H.J.

Published
2020

14. A Broad-Spectrum Antiviral Peptide Blocks Infection of Viruses by Binding to Phosphatidylserine in the Viral Envelope

Author

Infection & Immunity, MMB Research line 3a, Luteijn, Rutger D, Praest, Patrique, Thiele, Frank, Sadasivam, Saravanan Manikam, Singethan, Katrin, Drijfhout, Jan W, Bach, Christian, de Boer, Steffen Matthijn, Lebbink, Robert J, Tao, Sha, Helfer, Markus, Bach, Nina C, Protzer, Ulrike, Costa, Ana I, Killian, J Antoinette, Drexler, Ingo, Wiertz, Emmanuel J H J, Infection & Immunity, MMB Research line 3a, Luteijn, Rutger D, Praest, Patrique, Thiele, Frank, Sadasivam, Saravanan Manikam, Singethan, Katrin, Drijfhout, Jan W, Bach, Christian, de Boer, Steffen Matthijn, Lebbink, Robert J, Tao, Sha, Helfer, Markus, Bach, Nina C, Protzer, Ulrike, Costa, Ana I, Killian, J Antoinette, Drexler, Ingo, and Wiertz, Emmanuel J H J

Published
2020

15. Splenic Red Pulp Macrophages Cross-Prime Early Effector CTL That Provide Rapid Defense against Viral Infections

Author

MMB Research line 3a, Infection & Immunity, Enders, Marika, Franken, Lars, Philipp, Marie-Sophie, Kessler, Nina, Baumgart, Ann-Kathrin, Eichler, Melanie, Wiertz, Emmanuel J H, Garbi, Natalio, Kurts, Christian, MMB Research line 3a, Infection & Immunity, Enders, Marika, Franken, Lars, Philipp, Marie-Sophie, Kessler, Nina, Baumgart, Ann-Kathrin, Eichler, Melanie, Wiertz, Emmanuel J H, Garbi, Natalio, and Kurts, Christian

Published
2020

16. New insights into the structure of the MHC class I peptide-loading complex and mechanisms of TAP inhibition by viral immune evasion proteins

Author

Praest, Patrique, Liaci, A Manuel, Förster, Friedrich, Wiertz, Emmanuel J H J, Praest, Patrique, Liaci, A Manuel, Förster, Friedrich, and Wiertz, Emmanuel J H J

Abstract

Several hundred million years of co-evolution of vertebrates and invading pathogens have shaped the adaptive immune system to fight back the unwanted invaders through highly sophisticated defense mechanisms. Herpesviruses manage to dodge this immune response by hampering one of the central hinges of human adaptive immunity, the major histocompatibility complex (MHC) class I antigen presentation pathway. One of the bottlenecks of this pathway is the loading of pathogen-derived peptides onto MHC-I molecules in the endoplasmic reticulum (ER). This task is accomplished by the MHC class I peptide-loading complex (PLC), of which the transporter associated with antigen-processing (TAP) is a central component. In this review, we summarize recent structural and functional insights into the molecular architecture of the PLC, how TAP accomplishes the transport of peptides across the ER membrane, and how herpes- and poxviruses inhibit TAP-mediated peptide translocation and subsequent antigen presentation.

Published
2019

20. Fluorescent TAP as a Platform for Virus-Induced Degradation of the Antigenic Peptide Transporter

Author

Wąchalska, Magda, Graul, Małgorzata, Praest, Patrique, Luteijn, Rutger D, Babnis, Aleksandra W, Wiertz, Emmanuel J H J, Bieńkowska-Szewczyk, Krystyna, Lipińska, Andrea D, Wąchalska, Magda, Graul, Małgorzata, Praest, Patrique, Luteijn, Rutger D, Babnis, Aleksandra W, Wiertz, Emmanuel J H J, Bieńkowska-Szewczyk, Krystyna, and Lipińska, Andrea D

Published
2019

21. Transmembrane regions of bovine herpesvirus 1-encoded UL49.5 and glycoprotein M regulate complex maturation and ER-Golgi trafficking

Author

Graul, Malgorzata, Kisielnicka, Edyta, Rychlowski, Michal, Verweij, Marieke C., Tobler, Kurt, Ackermann, Mathias, Wiertz, Emmanuel J.H.J., Bieńkowska-Szewczyk, Krystyna, Lipińska, Andrea D., Graul, Malgorzata, Kisielnicka, Edyta, Rychlowski, Michal, Verweij, Marieke C., Tobler, Kurt, Ackermann, Mathias, Wiertz, Emmanuel J.H.J., Bieńkowska-Szewczyk, Krystyna, and Lipińska, Andrea D.

Published
2019

22. A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection

Author

Luteijn, Rutger D, van Diemen, Ferdy, Blomen, Vincent A, Boer, Ingrid G J, Manikam Sadasivam, Saravanan, van Kuppevelt, Toin H, Drexler, Ingo, Brummelkamp, Thijn R, Lebbink, Robert Jan, Wiertz, Emmanuel J, Luteijn, Rutger D, van Diemen, Ferdy, Blomen, Vincent A, Boer, Ingrid G J, Manikam Sadasivam, Saravanan, van Kuppevelt, Toin H, Drexler, Ingo, Brummelkamp, Thijn R, Lebbink, Robert Jan, and Wiertz, Emmanuel J

Published
2019

26. A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection

Author

Luteijn, Rutger D, van Diemen, Ferdy, Blomen, Vincent A, Boer, Ingrid G J, Manikam Sadasivam, Saravanan, van Kuppevelt, Toin H, Drexler, Ingo, Brummelkamp, Thijn R, Lebbink, Robert Jan, Wiertz, Emmanuel J, Luteijn, Rutger D, van Diemen, Ferdy, Blomen, Vincent A, Boer, Ingrid G J, Manikam Sadasivam, Saravanan, van Kuppevelt, Toin H, Drexler, Ingo, Brummelkamp, Thijn R, Lebbink, Robert Jan, and Wiertz, Emmanuel J

Published
2019

27. Fluorescent TAP as a Platform for Virus-Induced Degradation of the Antigenic Peptide Transporter

Author

Wąchalska, Magda, Graul, Małgorzata, Praest, Patrique, Luteijn, Rutger D, Babnis, Aleksandra W, Wiertz, Emmanuel J H J, Bieńkowska-Szewczyk, Krystyna, Lipińska, Andrea D, Wąchalska, Magda, Graul, Małgorzata, Praest, Patrique, Luteijn, Rutger D, Babnis, Aleksandra W, Wiertz, Emmanuel J H J, Bieńkowska-Szewczyk, Krystyna, and Lipińska, Andrea D

Published
2019

32. Transmembrane regions of bovine herpesvirus 1-encoded UL49.5 and glycoprotein M regulate complex maturation and ER-Golgi trafficking

Author

Graul, Malgorzata, Kisielnicka, Edyta, Rychlowski, Michal, Verweij, Marieke C., Tobler, Kurt, Ackermann, Mathias, Wiertz, Emmanuel J.H.J., Bieńkowska-Szewczyk, Krystyna, Lipińska, Andrea D., Graul, Malgorzata, Kisielnicka, Edyta, Rychlowski, Michal, Verweij, Marieke C., Tobler, Kurt, Ackermann, Mathias, Wiertz, Emmanuel J.H.J., Bieńkowska-Szewczyk, Krystyna, and Lipińska, Andrea D.

Published
2019

33. Fluorescent TAP as a Platform for Virus-Induced Degradation of the Antigenic Peptide Transporter

Author

Wąchalska, Magda, Graul, Małgorzata, Praest, Patrique, Luteijn, Rutger D, Babnis, Aleksandra W, Wiertz, Emmanuel J H J, Bieńkowska-Szewczyk, Krystyna, Lipińska, Andrea D, Wąchalska, Magda, Graul, Małgorzata, Praest, Patrique, Luteijn, Rutger D, Babnis, Aleksandra W, Wiertz, Emmanuel J H J, Bieńkowska-Szewczyk, Krystyna, and Lipińska, Andrea D

Published
2019

34. Transmembrane regions of bovine herpesvirus 1-encoded UL49.5 and glycoprotein M regulate complex maturation and ER-Golgi trafficking

Author

Graul, Malgorzata, Kisielnicka, Edyta, Rychlowski, Michal, Verweij, Marieke C., Tobler, Kurt, Ackermann, Mathias, Wiertz, Emmanuel J.H.J., Bieńkowska-Szewczyk, Krystyna, Lipińska, Andrea D., Graul, Malgorzata, Kisielnicka, Edyta, Rychlowski, Michal, Verweij, Marieke C., Tobler, Kurt, Ackermann, Mathias, Wiertz, Emmanuel J.H.J., Bieńkowska-Szewczyk, Krystyna, and Lipińska, Andrea D.

Published
2019

36. A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection

Author

Luteijn, Rutger D, van Diemen, Ferdy, Blomen, Vincent A, Boer, Ingrid G J, Manikam Sadasivam, Saravanan, van Kuppevelt, Toin H, Drexler, Ingo, Brummelkamp, Thijn R, Lebbink, Robert Jan, Wiertz, Emmanuel J, Luteijn, Rutger D, van Diemen, Ferdy, Blomen, Vincent A, Boer, Ingrid G J, Manikam Sadasivam, Saravanan, van Kuppevelt, Toin H, Drexler, Ingo, Brummelkamp, Thijn R, Lebbink, Robert Jan, and Wiertz, Emmanuel J

Published
2019

44. Transmembrane regions of bovine herpesvirus 1-encoded UL49.5 and glycoprotein M regulate complex maturation and ER-Golgi trafficking

Author

MMB Research line 3a, Infection & Immunity, Graul, Malgorzata, Kisielnicka, Edyta, Rychlowski, Michal, Verweij, Marieke C., Tobler, Kurt, Ackermann, Mathias, Wiertz, Emmanuel J.H.J., Bieńkowska-Szewczyk, Krystyna, Lipińska, Andrea D., MMB Research line 3a, Infection & Immunity, Graul, Malgorzata, Kisielnicka, Edyta, Rychlowski, Michal, Verweij, Marieke C., Tobler, Kurt, Ackermann, Mathias, Wiertz, Emmanuel J.H.J., Bieńkowska-Szewczyk, Krystyna, and Lipińska, Andrea D.

Published
2019

45. Fluorescent TAP as a Platform for Virus-Induced Degradation of the Antigenic Peptide Transporter

Author

MMB Research line 3a, Infection & Immunity, Wąchalska, Magda, Graul, Małgorzata, Praest, Patrique, Luteijn, Rutger D, Babnis, Aleksandra W, Wiertz, Emmanuel J H J, Bieńkowska-Szewczyk, Krystyna, Lipińska, Andrea D, MMB Research line 3a, Infection & Immunity, Wąchalska, Magda, Graul, Małgorzata, Praest, Patrique, Luteijn, Rutger D, Babnis, Aleksandra W, Wiertz, Emmanuel J H J, Bieńkowska-Szewczyk, Krystyna, and Lipińska, Andrea D

Published
2019

46. A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection

Author

MMB Research line 3a, Infection & Immunity, CMM Sectie Molecular Cancer Research, Cancer, Luteijn, Rutger D, van Diemen, Ferdy, Blomen, Vincent A, Boer, Ingrid G J, Manikam Sadasivam, Saravanan, van Kuppevelt, Toin H, Drexler, Ingo, Brummelkamp, Thijn R, Lebbink, Robert Jan, Wiertz, Emmanuel J, MMB Research line 3a, Infection & Immunity, CMM Sectie Molecular Cancer Research, Cancer, Luteijn, Rutger D, van Diemen, Ferdy, Blomen, Vincent A, Boer, Ingrid G J, Manikam Sadasivam, Saravanan, van Kuppevelt, Toin H, Drexler, Ingo, Brummelkamp, Thijn R, Lebbink, Robert Jan, and Wiertz, Emmanuel J

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results