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Медичне цитування: Путівник NLM для авторів, редакторів і видавців, Медицинское цитирования: Путеводитель NLM для авторов, редакторов и издателей, Citing Medicine: The NLM Style Guide for Authors, Editors, and Publishers (Ukrainian translation)

Citing Medicine: The NLM Style Guide for Authors, Editors, and Publishers (Ukrainian translation)

Медичне цитування:Путівник NLM для авторів, редакторів і видавців, Citing Medicine: The NLM Style Guide for Authors, Editors, and Publishers (Ukrainian translation), Медицинское цитирования: Путеводитель NLM для авторов, редакторов и издателей

Citing Medicine: The NLM Style Guide for Authors, Editors, and Publishers (Ukrainian translation), Медицинское цитирования: Путеводитель NLM для авторов, редакторов и издателей, Медичне цитування: Путівник NLM для авторів, редакторів і видавців

Citing Medicine: The NLM Style Guide for Authors, Editors, and Publishers (Ukrainian translation), Медицинское цитирования: Путеводитель NLM для авторов, редакторов и издателей, Медичне цитування: Путівник NLM для авторів, редакторів і видавців

Citing medicine: the NLM style guide for authors, editors, and publishers (ukrainian translation), Медицинское цитирование: путеводитель NLM для авторов, редакторов и издателей, Медичне цитування: путівник NLM для авторів, редакторів і видавців

In spondyloarthritis, little is known about the relation between circulating cytokines and patient phenotype. We have quantified serum levels of T helper type 1 cell (Th1), Th2 and Th17 cytokines in patients with recent-onset axial spondyloarthritis (AxSpA) from the DESIR cohort, a prospective, multicenter French cohort consisting of 708 patients with recent-onset inflammatory back pain (duration >3 months but <3 years) suggestive of AxSpA. Serum levels of Th1, Th2, and Th17 cytokines were assessed at baseline in patients from the DESIR cohort fulfilling the ASAS criteria (ASAS+) and were compared with age- and sex-matched healthy controls. At baseline, ASAS+ patients (n = 443) and healthy controls (n = 79) did not differ in levels of most of the Th1, Th2 and Th17 cytokines except for IL-31, and sCD40L, which were significantly higher for ASAS+ patients than controls (p < 0.001 and p = 0.012, respectively). On multivariable analysis of ASAS+ patients, IL-31 level was associated with sCD40L level (p < 0.0001), modified Stoke AS Spine Score (mSASSS) < 1 (p = 0.035). The multivariable analyses showed that IL-31 was an independent factor associated with mSASSS < 1 (p = 0.001) and low bone mineral density (p = 0.01). Increased level of IL-31 might protect against structural damage but is also related to low BMD.

Citing Medicine: The NLM Style Guide for Authors, Editors, and Publishers (Ukrainian translation), Медицинское цитирования: Путеводитель NLM для авторов, редакторов и издателей, Медичне цитування: Путівник NLM для авторів, редакторів і видавців

Citing Medicine: The NLM Style Guide for Authors, Editors, and Publishers (Ukrainian translation), Медицинское цитирования: Путеводитель NLM для авторов, редакторов и издателей, Медичне цитування: Путівник NLM для авторів, редакторів і видавців

Citing Medicine: The NLM Style Guide for Authors, Editors, and Publishers (Ukrainian translation), Медицинское цитирования: Путеводитель NLM для авторов, редакторов и издателей, Медичне цитування:Путівник NLM для авторів, редакторів і видавців

Citing Medicine: The NLM Style Guide for Authors, Editors, and Publishers (Ukrainian translation), Медицинское цитирования: Путеводитель NLM для авторов, редакторов и издателей, Медичне цитування: Путівник NLM для авторів, редакторів і видавців

Citing Medicine: The NLM Style Guide for Authors, Editors, and Publishers (Ukrainian translation), Медицинское цитирования: Путеводитель NLM для авторов, редакторов и издателей, Медичне цитування: Путівник NLM для авторів, редакторів і видавців

Citing Medicine: The NLM Style Guide for Authors, Editors, and Publishers (Ukrainian translation), Медицинское цитирования: Путеводитель NLM для авторов, редакторов и издателей, Медичне цитування: Путівник NLM для авторів, редакторів і видавців

Objectives: DESIR is a prospective longitudinal multicentric French cohort of patients with inflammatory back pain suggestive of spondyloarthritis, with a 10-year-follow-up. The purpose is to evaluate the performances of the different sets of classification criteria for axial spondyloarthritis, and to describe the frequency and characteristics of the clinical features of axial spondyloarthritis. Methods: Demographic data and items allowing classification and indices calculation were collected, as well as biologic and imaging data. Baseline data are analyzed. The performance of the several classification criteria sets was evaluated (likelihood ratio) with the physician's diagnosis as external gold standard. For the clinical presentation of axial spondyloarthritis, a descriptive analysis was conducted. Results: Seven hundred and eight patients are included. Ninety-two percent of them satisfy at least one set of classification criteria: mNY 26%, Amor 79%, ESSG 78%, ASAS 70%; physician's confidence level 6.8 ± 2.7. 81 and 83% of patients fulfil modified (including MRI) Amor or ESSG criteria. Axial involvement is present in 100% of the cases. NSAIDs are taken by 90%, with an NSAID sore of 50 ± 46. BASDAI over 40 is noted in 60% and elevated CRP in 30% of the cases. HLA-B27 is present in 58%. According to ASDAS CRP levels, 12.7% are in inactive disease, 63% in high disease activity; mean BASFI was 30. Peripheral involvement is present in 57%, with arthritis in 37% of these. Enthesitis is noted in 49% of the patients, and first symptom in 22.5%; anterior chest wall involvement is noted in 44.6%, and dactylitis in 13%. For extra articular manifestations, psoriasis is recorded in 16%, uveitis in 8.5% and IBD in 5.1%. Smoking is present in 36.3% and hypertension in 5.1% of the cases. Conclusion: These data represent the base of evaluation of the follow-up of this cohort, allowing future specific studies.

Citing Medicine: The NLM Style Guide for Authors, Editors, and Publishers (Ukrainian translation), Медицинское цитирования: Путеводитель NLM для авторов, редакторов и издателей, Медичне цитування: Путівник NLM для авторів, редакторів і видавців

Citing Medicine: The NLM Style Guide for Authors, Editors, and Publishers (Ukrainian translation)., Медицинское цитирования: Путеводитель NLM для авторов, редакторов и издателей., Медичне цитування: Путівник NLM для авторів, редакторів і видавців.

We present a labelled sequent calculus for Boolean BI (BBI), a classical variant of the logic of Bunched Implication. The calculus is simple, sound, complete, and enjoys cut-elimination. We show that all the structural rules in the calculus, i.e., those r

Objectives: The French Society of Rheumatology has initiated a large national multicenter, longitudinal, prospective follow-up of patients presenting with early inflammatory back pain in order to set up a database to facilitate several investigations on diagnosis, prognosis, epidemiology, pathogenesis and medico-economics in the field of early inflammatory back pain and spondyloarthritis. Methods: Patients were recruited if they had inflammatory back pain of more than 3. months and less than 3. years. Patients will be followed every 6. months during the first 2. years then every year during at least 5. years. Apart from information collected on a Case Report Form (demographics, disease activity, severity, co-morbidities, socio-economics, treatments, radiological and MRI evaluation of the spine and the pelvis according to the local investigators, and for some centers bone densitometry and ultrasonography of entheses), the digital X-rays and MRI of the spine and pelvis are stored using a specific software (Carestream) and the biological samples (DNA, RNA, sera, urines) are centralized at the Biological Resources Center (Bichat Hospital). Results: The recruitment period of the 708 patients (mean age: 34 ± 9. years, female 54%, HLA-B27 positive: 57%) in the 25 centers was 26. months (from December 2007 to April 2010). The modified New York criteria, Amor criteria, ESSG criteria and axial ASAS criteria were fulfilled by 26%, 77%, 76% and 67% of the patients at entry, respectively. A history or current symptoms suggestive of peripheral arthritis, acute anterior uveitis and inflammatory bowel disease were observed in 21%, 9% and 4% of the patients, respectively. The disease was active (BASDAI: 45 ± 20) despite an NSAID intake in 66% of the patients. Conclusion: This large cohort should facilitate the conduct of researches in different areas (clinical, medico-economics, translational) in order to improve our knowledge on the pathogenesis and natural history of axial spondyl