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1. ECLAPTE:Effective Closure of LAParoTomy in Emergency-2023 World Society of Emergency Surgery guidelines for the closure of laparotomy in emergency settings

Author: Frassini, Simone, Cobianchi, Lorenzo, Fugazzola, Paola, Biffl, Walter L., Coccolini, Federico, Damaskos, Dimitrios, Moore, Ernest E., Kluger, Yoram, Ceresoli, Marco, Coimbra, Raul, Davies, Justin, Kirkpatrick, Andrew, Di Carlo, Isidoro, Hardcastle, Timothy C., Isik, Arda, Chiarugi, Massimo, Gurusamy, Kurinchi, Maier, Ronald V., Segovia Lohse, Helmut A., Jeekel, Hans, Boermeester, Marja A., Abu-Zidan, Fikri, Inaba, Kenji, Weber, Dieter G., Augustin, Goran, Bonavina, Luigi, Velmahos, George, Sartelli, Massimo, Di Saverio, Salomone, Ten Broek, Richard P.G., Granieri, Stefano, Dal Mas, Francesca, Farè, Camilla Nikita, Peverada, Jacopo, Zanghì, Simone, Viganò, Jacopo, Tomasoni, Matteo, Dominioni, Tommaso, Cicuttin, Enrico, Hecker, Andreas, Tebala, Giovanni D., Galante, Joseph M., Wani, Imtiaz, Khokha, Vladimir, Sugrue, Michael, Scalea, Thomas M., Tan, Edward, Malangoni, Mark A., Pararas, Nikolaos, Podda, Mauro, De Simone, Belinda, Ivatury, Rao, Cui, Yunfeng, Kashuk, Jeffry, Peitzman, Andrew, Kim, Fernando, Pikoulis, Emmanouil, Sganga, Gabriele, Chiara, Osvaldo, Kelly, Michael D., Marzi, Ingo, Picetti, Edoardo, Agnoletti, Vanni, De'Angelis, Nicola, Campanelli, Giampiero, de Moya, Marc, Litvin, Andrey, Martínez-Pérez, Aleix, Sall, Ibrahima, Rizoli, Sandro, Tomadze, Gia, Sakakushev, Boris, Stahel, Philip F., Civil, Ian, Shelat, Vishal, Costa, David, Chichom-Mefire, Alain, Latifi, Rifat, Chirica, Mircea, Amico, Francesco, Pardhan, Amyn, Seenarain, Vidya, Boyapati, Nikitha, Hatz, Basil, Ackermann, Travis, Abeyasundara, Sandun, Fenton, Linda, Plani, Frank, Sarvepalli, Rohit, Rouhbakhshfar, Omid, Caleo, Pamela, Ho-Ching Yau, Victor, Clement, Kristenne, Christou, Erasmia, Castillo, Ana María González, Gosal, Preet K.S., Balasubramaniam, Sunder, Hsu, Jeremy, Banphawatanarak, Kamon, Pisano, Michele, Adriana, Toro, Michele, Altomare, Cioffi, Stefano P.B., Spota, Andrea, Catena, Fausto, Ansaloni, Luca, Frassini, Simone, Cobianchi, Lorenzo, Fugazzola, Paola, Biffl, Walter L., Coccolini, Federico, Damaskos, Dimitrios, Moore, Ernest E., Kluger, Yoram, Ceresoli, Marco, Coimbra, Raul, Davies, Justin, Kirkpatrick, Andrew, Di Carlo, Isidoro, Hardcastle, Timothy C., Isik, Arda, Chiarugi, Massimo, Gurusamy, Kurinchi, Maier, Ronald V., Segovia Lohse, Helmut A., Jeekel, Hans, Boermeester, Marja A., Abu-Zidan, Fikri, Inaba, Kenji, Weber, Dieter G., Augustin, Goran, Bonavina, Luigi, Velmahos, George, Sartelli, Massimo, Di Saverio, Salomone, Ten Broek, Richard P.G., Granieri, Stefano, Dal Mas, Francesca, Farè, Camilla Nikita, Peverada, Jacopo, Zanghì, Simone, Viganò, Jacopo, Tomasoni, Matteo, Dominioni, Tommaso, Cicuttin, Enrico, Hecker, Andreas, Tebala, Giovanni D., Galante, Joseph M., Wani, Imtiaz, Khokha, Vladimir, Sugrue, Michael, Scalea, Thomas M., Tan, Edward, Malangoni, Mark A., Pararas, Nikolaos, Podda, Mauro, De Simone, Belinda, Ivatury, Rao, Cui, Yunfeng, Kashuk, Jeffry, Peitzman, Andrew, Kim, Fernando, Pikoulis, Emmanouil, Sganga, Gabriele, Chiara, Osvaldo, Kelly, Michael D., Marzi, Ingo, Picetti, Edoardo, Agnoletti, Vanni, De'Angelis, Nicola, Campanelli, Giampiero, de Moya, Marc, Litvin, Andrey, Martínez-Pérez, Aleix, Sall, Ibrahima, Rizoli, Sandro, Tomadze, Gia, Sakakushev, Boris, Stahel, Philip F., Civil, Ian, Shelat, Vishal, Costa, David, Chichom-Mefire, Alain, Latifi, Rifat, Chirica, Mircea, Amico, Francesco, Pardhan, Amyn, Seenarain, Vidya, Boyapati, Nikitha, Hatz, Basil, Ackermann, Travis, Abeyasundara, Sandun, Fenton, Linda, Plani, Frank, Sarvepalli, Rohit, Rouhbakhshfar, Omid, Caleo, Pamela, Ho-Ching Yau, Victor, Clement, Kristenne, Christou, Erasmia, Castillo, Ana María González, Gosal, Preet K.S., Balasubramaniam, Sunder, Hsu, Jeremy, Banphawatanarak, Kamon, Pisano, Michele, Adriana, Toro, Michele, Altomare, Cioffi, Stefano P.B., Spota, Andrea, Catena, Fausto, and Ansaloni, Luca
Abstract: Laparotomy incisions provide easy and rapid access to the peritoneal cavity in case of emergency surgery. Incisional hernia (IH) is a late manifestation of the failure of abdominal wall closure and represents frequent complication of any abdominal incision: IHs can cause pain and discomfort to the patients but also clinical serious sequelae like bowel obstruction, incarceration, strangulation, and necessity of reoperation. Previous guidelines and indications in the literature consider elective settings and evidence about laparotomy closure in emergency settings is lacking. This paper aims to present the World Society of Emergency Surgery (WSES) project called ECLAPTE (Effective Closure of LAParoTomy in Emergency): the final manuscript includes guidelines on the closure of emergency laparotomy.
Published: 2023

2. Enhanced perioperative care in emergency general surgery:the WSES position paper

Author: Ceresoli, Marco, Braga, Marco, Zanini, Nicola, Abu-Zidan, Fikri M., Parini, Dario, Langer, Thomas, Sartelli, Massimo, Damaskos, Dimitrios, Biffl, Walter L., Amico, Francesco, Ansaloni, Luca, Balogh, Zsolt J., Bonavina, Luigi, Civil, Ian, Cicuttin, Enrico, Chirica, Mircea, Cui, Yunfeng, De Simone, Belinda, Di Carlo, Isidoro, Fette, Andreas, Foti, Giuseppe, Fogliata, Michele, Fraga, Gustavo P., Fugazzola, Paola, Galante, Joseph M., Beka, Solomon Gurmu, Hecker, Andreas, Jeekel, Johannes, Kirkpatrick, Andrew W., Koike, Kaoru, Leppäniemi, Ari, Marzi, Ingo, Moore, Ernest E., Picetti, Edoardo, Pikoulis, Emmanouil, Pisano, Michele, Podda, Mauro, Sakakushev, Boris E., Shelat, Vishal G., Tan, Edward, Tebala, Giovanni D., Velmahos, George, Weber, Dieter G., Agnoletti, Vanni, Kluger, Yoram, Baiocchi, Gianluca, Catena, Fausto, Coccolini, Federico, Ceresoli, Marco, Braga, Marco, Zanini, Nicola, Abu-Zidan, Fikri M., Parini, Dario, Langer, Thomas, Sartelli, Massimo, Damaskos, Dimitrios, Biffl, Walter L., Amico, Francesco, Ansaloni, Luca, Balogh, Zsolt J., Bonavina, Luigi, Civil, Ian, Cicuttin, Enrico, Chirica, Mircea, Cui, Yunfeng, De Simone, Belinda, Di Carlo, Isidoro, Fette, Andreas, Foti, Giuseppe, Fogliata, Michele, Fraga, Gustavo P., Fugazzola, Paola, Galante, Joseph M., Beka, Solomon Gurmu, Hecker, Andreas, Jeekel, Johannes, Kirkpatrick, Andrew W., Koike, Kaoru, Leppäniemi, Ari, Marzi, Ingo, Moore, Ernest E., Picetti, Edoardo, Pikoulis, Emmanouil, Pisano, Michele, Podda, Mauro, Sakakushev, Boris E., Shelat, Vishal G., Tan, Edward, Tebala, Giovanni D., Velmahos, George, Weber, Dieter G., Agnoletti, Vanni, Kluger, Yoram, Baiocchi, Gianluca, Catena, Fausto, and Coccolini, Federico
Abstract: Enhanced perioperative care protocols become the standard of care in elective surgery with a significant improvement in patients' outcome. The key element of the enhanced perioperative care protocol is the multimodal and interdisciplinary approach targeted to the patient, focused on a holistic approach to reduce surgical stress and improve perioperative recovery. Enhanced perioperative care in emergency general surgery is still a debated topic with little evidence available. The present position paper illustrates the existing evidence about perioperative care in emergency surgery patients with a focus on each perioperative intervention in the preoperative, intraoperative and postoperative phase. For each item was proposed and approved a statement by the WSES collaborative group.
Published: 2023

3. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines

Author: Di Saverio, Salomone, Podda, Mauro, De Simone, Belinda, Ceresoli, Marco, Augustin, Goran, Gori, Alice, Boermeester, Marja, Sartelli, Massimo, Coccolini, Federico, Tarasconi, Antonio, Angelis, Nicola de, Weber, Dieter G., Tolonen, Matti, Birindelli, Arianna, Biffl, Walter, Moore, Ernest E., Kelly, Michael, Soreide, Kjetil, Kashuk, Jeffry, Ten Broek, Richard, Gomes, Carlos Augusto, Sugrue, Michael, Davies, Richard Justin, Damaskos, Dimitrios, Leppaniemi, Ari, Kirkpatrick, Andrew, Peitzman, Andrew B., Fraga, Gustavo P., Maier, Ronald V., Coimbra, Raul, Chiarugi, Massimo, Sganga, Gabriele, Pisanu, Adolfo, Angelis, Gian Luigi de, Tan, Edward, Van Goor, Harry, Pata, Francesco, Di Carlo, Isidoro, Chiara, Osvaldo, Litvin, Andrey, Campanile, Fabio C., Sakakushev, Boris, Tomadze, Gia, Demetrashvili, Zaza, Latifi, Rifat, Abu-Zidan, Fakri, Romeo, Oreste, Segovia-Lohse, Helmut, Baiocchi, Gianluca, Costa, David, Rizoli, Sandro, Balogh, Zsolt J., Bendinelli, Cino, Scalea, Thomas, Ivatury, Rao, Velmahos, George, Andersson, Roland, Kluger, Yoram, Ansaloni, Luca, Catena, Fausto, Di Saverio, Salomone, Podda, Mauro, De Simone, Belinda, Ceresoli, Marco, Augustin, Goran, Gori, Alice, Boermeester, Marja, Sartelli, Massimo, Coccolini, Federico, Tarasconi, Antonio, Angelis, Nicola de, Weber, Dieter G., Tolonen, Matti, Birindelli, Arianna, Biffl, Walter, Moore, Ernest E., Kelly, Michael, Soreide, Kjetil, Kashuk, Jeffry, Ten Broek, Richard, Gomes, Carlos Augusto, Sugrue, Michael, Davies, Richard Justin, Damaskos, Dimitrios, Leppaniemi, Ari, Kirkpatrick, Andrew, Peitzman, Andrew B., Fraga, Gustavo P., Maier, Ronald V., Coimbra, Raul, Chiarugi, Massimo, Sganga, Gabriele, Pisanu, Adolfo, Angelis, Gian Luigi de, Tan, Edward, Van Goor, Harry, Pata, Francesco, Di Carlo, Isidoro, Chiara, Osvaldo, Litvin, Andrey, Campanile, Fabio C., Sakakushev, Boris, Tomadze, Gia, Demetrashvili, Zaza, Latifi, Rifat, Abu-Zidan, Fakri, Romeo, Oreste, Segovia-Lohse, Helmut, Baiocchi, Gianluca, Costa, David, Rizoli, Sandro, Balogh, Zsolt J., Bendinelli, Cino, Scalea, Thomas, Ivatury, Rao, Velmahos, George, Andersson, Roland, Kluger, Yoram, Ansaloni, Luca, and Catena, Fausto
Abstract: Background and aims Acute appendicitis (AA) is among the most common causes of acute abdominal pain. Diagnosis of AA is still challenging and some controversies on its management are still present among different settings and practice patterns worldwide. In July 2015, the World Society of Emergency Surgery (WSES) organized in Jerusalem the first consensus conference on the diagnosis and treatment of AA in adult patients with the intention of producing evidence-based guidelines. An updated consensus conference took place in Nijemegen in June 2019 and the guidelines have now been updated in order to provide evidence-based statements and recommendations in keeping with varying clinical practice: use of clinical scores and imaging in diagnosing AA, indications and timing for surgery, use of non-operative management and antibiotics, laparoscopy and surgical techniques, intra-operative scoring, and peri-operative antibiotic therapy. Methods This executive manuscript summarizes the WSES guidelines for the diagnosis and treatment of AA. Literature search has been updated up to 2019 and statements and recommendations have been developed according to the GRADE methodology. The statements were voted, eventually modified, and finally approved by the participants to the consensus conference and by the board of co-authors, using a Delphi methodology for voting whenever there was controversy on a statement or a recommendation. Several tables highlighting the research topics and questions, search syntaxes, and the statements and the WSES evidence-based recommendations are provided. Finally, two different practical clinical algorithms are provided in the form of a flow chart for both adults and pediatric (< 16 years old) patients. Conclusions The 2020 WSES guidelines on AA aim to provide updated evidence-based statements and recommendations on each of the following topics: (1) diagnosis, (2) non-operative management for uncomplicated AA, (3) timing of appendectomy and in-hosp
Published: 2020
Full Text: View/download PDF

4. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines

Author: Di Saverio, Salomone, Podda, Mauro, De Simone, Belinda, Ceresoli, Marco, Augustin, Goran, Gori, Alice, Boermeester, Marja, Sartelli, Massimo, Coccolini, Federico, Tarasconi, Antonio, Angelis, Nicola de, Weber, Dieter G., Tolonen, Matti, Birindelli, Arianna, Biffl, Walter, Moore, Ernest E., Kelly, Michael, Soreide, Kjetil, Kashuk, Jeffry, Ten Broek, Richard, Gomes, Carlos Augusto, Sugrue, Michael, Davies, Richard Justin, Damaskos, Dimitrios, Leppaniemi, Ari, Kirkpatrick, Andrew, Peitzman, Andrew B., Fraga, Gustavo P., Maier, Ronald V., Coimbra, Raul, Chiarugi, Massimo, Sganga, Gabriele, Pisanu, Adolfo, Angelis, Gian Luigi de, Tan, Edward, Van Goor, Harry, Pata, Francesco, Di Carlo, Isidoro, Chiara, Osvaldo, Litvin, Andrey, Campanile, Fabio C., Sakakushev, Boris, Tomadze, Gia, Demetrashvili, Zaza, Latifi, Rifat, Abu-Zidan, Fakri, Romeo, Oreste, Segovia-Lohse, Helmut, Baiocchi, Gianluca, Costa, David, Rizoli, Sandro, Balogh, Zsolt J., Bendinelli, Cino, Scalea, Thomas, Ivatury, Rao, Velmahos, George, Andersson, Roland, Kluger, Yoram, Ansaloni, Luca, Catena, Fausto, Di Saverio, Salomone, Podda, Mauro, De Simone, Belinda, Ceresoli, Marco, Augustin, Goran, Gori, Alice, Boermeester, Marja, Sartelli, Massimo, Coccolini, Federico, Tarasconi, Antonio, Angelis, Nicola de, Weber, Dieter G., Tolonen, Matti, Birindelli, Arianna, Biffl, Walter, Moore, Ernest E., Kelly, Michael, Soreide, Kjetil, Kashuk, Jeffry, Ten Broek, Richard, Gomes, Carlos Augusto, Sugrue, Michael, Davies, Richard Justin, Damaskos, Dimitrios, Leppaniemi, Ari, Kirkpatrick, Andrew, Peitzman, Andrew B., Fraga, Gustavo P., Maier, Ronald V., Coimbra, Raul, Chiarugi, Massimo, Sganga, Gabriele, Pisanu, Adolfo, Angelis, Gian Luigi de, Tan, Edward, Van Goor, Harry, Pata, Francesco, Di Carlo, Isidoro, Chiara, Osvaldo, Litvin, Andrey, Campanile, Fabio C., Sakakushev, Boris, Tomadze, Gia, Demetrashvili, Zaza, Latifi, Rifat, Abu-Zidan, Fakri, Romeo, Oreste, Segovia-Lohse, Helmut, Baiocchi, Gianluca, Costa, David, Rizoli, Sandro, Balogh, Zsolt J., Bendinelli, Cino, Scalea, Thomas, Ivatury, Rao, Velmahos, George, Andersson, Roland, Kluger, Yoram, Ansaloni, Luca, and Catena, Fausto
Abstract: Background and aims Acute appendicitis (AA) is among the most common causes of acute abdominal pain. Diagnosis of AA is still challenging and some controversies on its management are still present among different settings and practice patterns worldwide. In July 2015, the World Society of Emergency Surgery (WSES) organized in Jerusalem the first consensus conference on the diagnosis and treatment of AA in adult patients with the intention of producing evidence-based guidelines. An updated consensus conference took place in Nijemegen in June 2019 and the guidelines have now been updated in order to provide evidence-based statements and recommendations in keeping with varying clinical practice: use of clinical scores and imaging in diagnosing AA, indications and timing for surgery, use of non-operative management and antibiotics, laparoscopy and surgical techniques, intra-operative scoring, and peri-operative antibiotic therapy. Methods This executive manuscript summarizes the WSES guidelines for the diagnosis and treatment of AA. Literature search has been updated up to 2019 and statements and recommendations have been developed according to the GRADE methodology. The statements were voted, eventually modified, and finally approved by the participants to the consensus conference and by the board of co-authors, using a Delphi methodology for voting whenever there was controversy on a statement or a recommendation. Several tables highlighting the research topics and questions, search syntaxes, and the statements and the WSES evidence-based recommendations are provided. Finally, two different practical clinical algorithms are provided in the form of a flow chart for both adults and pediatric (< 16 years old) patients. Conclusions The 2020 WSES guidelines on AA aim to provide updated evidence-based statements and recommendations on each of the following topics: (1) diagnosis, (2) non-operative management for uncomplicated AA, (3) timing of appendectomy and in-hosp
Published: 2020
Full Text: View/download PDF

5. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines

Author: Di Saverio, Salomone, Podda, Mauro, De Simone, Belinda, Ceresoli, Marco, Augustin, Goran, Gori, Alice, Boermeester, Marja, Sartelli, Massimo, Coccolini, Federico, Tarasconi, Antonio, Angelis, Nicola de, Weber, Dieter G., Tolonen, Matti, Birindelli, Arianna, Biffl, Walter, Moore, Ernest E., Kelly, Michael, Soreide, Kjetil, Kashuk, Jeffry, Ten Broek, Richard, Gomes, Carlos Augusto, Sugrue, Michael, Davies, Richard Justin, Damaskos, Dimitrios, Leppaniemi, Ari, Kirkpatrick, Andrew, Peitzman, Andrew B., Fraga, Gustavo P., Maier, Ronald V., Coimbra, Raul, Chiarugi, Massimo, Sganga, Gabriele, Pisanu, Adolfo, Angelis, Gian Luigi de, Tan, Edward, Van Goor, Harry, Pata, Francesco, Di Carlo, Isidoro, Chiara, Osvaldo, Litvin, Andrey, Campanile, Fabio C., Sakakushev, Boris, Tomadze, Gia, Demetrashvili, Zaza, Latifi, Rifat, Abu-Zidan, Fakri, Romeo, Oreste, Segovia-Lohse, Helmut, Baiocchi, Gianluca, Costa, David, Rizoli, Sandro, Balogh, Zsolt J., Bendinelli, Cino, Scalea, Thomas, Ivatury, Rao, Velmahos, George, Andersson, Roland, Kluger, Yoram, Ansaloni, Luca, Catena, Fausto, Di Saverio, Salomone, Podda, Mauro, De Simone, Belinda, Ceresoli, Marco, Augustin, Goran, Gori, Alice, Boermeester, Marja, Sartelli, Massimo, Coccolini, Federico, Tarasconi, Antonio, Angelis, Nicola de, Weber, Dieter G., Tolonen, Matti, Birindelli, Arianna, Biffl, Walter, Moore, Ernest E., Kelly, Michael, Soreide, Kjetil, Kashuk, Jeffry, Ten Broek, Richard, Gomes, Carlos Augusto, Sugrue, Michael, Davies, Richard Justin, Damaskos, Dimitrios, Leppaniemi, Ari, Kirkpatrick, Andrew, Peitzman, Andrew B., Fraga, Gustavo P., Maier, Ronald V., Coimbra, Raul, Chiarugi, Massimo, Sganga, Gabriele, Pisanu, Adolfo, Angelis, Gian Luigi de, Tan, Edward, Van Goor, Harry, Pata, Francesco, Di Carlo, Isidoro, Chiara, Osvaldo, Litvin, Andrey, Campanile, Fabio C., Sakakushev, Boris, Tomadze, Gia, Demetrashvili, Zaza, Latifi, Rifat, Abu-Zidan, Fakri, Romeo, Oreste, Segovia-Lohse, Helmut, Baiocchi, Gianluca, Costa, David, Rizoli, Sandro, Balogh, Zsolt J., Bendinelli, Cino, Scalea, Thomas, Ivatury, Rao, Velmahos, George, Andersson, Roland, Kluger, Yoram, Ansaloni, Luca, and Catena, Fausto
Abstract: Background and aims Acute appendicitis (AA) is among the most common causes of acute abdominal pain. Diagnosis of AA is still challenging and some controversies on its management are still present among different settings and practice patterns worldwide. In July 2015, the World Society of Emergency Surgery (WSES) organized in Jerusalem the first consensus conference on the diagnosis and treatment of AA in adult patients with the intention of producing evidence-based guidelines. An updated consensus conference took place in Nijemegen in June 2019 and the guidelines have now been updated in order to provide evidence-based statements and recommendations in keeping with varying clinical practice: use of clinical scores and imaging in diagnosing AA, indications and timing for surgery, use of non-operative management and antibiotics, laparoscopy and surgical techniques, intra-operative scoring, and peri-operative antibiotic therapy. Methods This executive manuscript summarizes the WSES guidelines for the diagnosis and treatment of AA. Literature search has been updated up to 2019 and statements and recommendations have been developed according to the GRADE methodology. The statements were voted, eventually modified, and finally approved by the participants to the consensus conference and by the board of co-authors, using a Delphi methodology for voting whenever there was controversy on a statement or a recommendation. Several tables highlighting the research topics and questions, search syntaxes, and the statements and the WSES evidence-based recommendations are provided. Finally, two different practical clinical algorithms are provided in the form of a flow chart for both adults and pediatric (< 16 years old) patients. Conclusions The 2020 WSES guidelines on AA aim to provide updated evidence-based statements and recommendations on each of the following topics: (1) diagnosis, (2) non-operative management for uncomplicated AA, (3) timing of appendectomy and in-hosp
Published: 2020
Full Text: View/download PDF

6. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines

Author: Di Saverio, Salomone, Podda, Mauro, De Simone, Belinda, Ceresoli, Marco, Augustin, Goran, Gori, Alice, Boermeester, Marja, Sartelli, Massimo, Coccolini, Federico, Tarasconi, Antonio, Angelis, Nicola de, Weber, Dieter G., Tolonen, Matti, Birindelli, Arianna, Biffl, Walter, Moore, Ernest E., Kelly, Michael, Soreide, Kjetil, Kashuk, Jeffry, Ten Broek, Richard, Gomes, Carlos Augusto, Sugrue, Michael, Davies, Richard Justin, Damaskos, Dimitrios, Leppaniemi, Ari, Kirkpatrick, Andrew, Peitzman, Andrew B., Fraga, Gustavo P., Maier, Ronald V., Coimbra, Raul, Chiarugi, Massimo, Sganga, Gabriele, Pisanu, Adolfo, Angelis, Gian Luigi de, Tan, Edward, Van Goor, Harry, Pata, Francesco, Di Carlo, Isidoro, Chiara, Osvaldo, Litvin, Andrey, Campanile, Fabio C., Sakakushev, Boris, Tomadze, Gia, Demetrashvili, Zaza, Latifi, Rifat, Abu-Zidan, Fakri, Romeo, Oreste, Segovia-Lohse, Helmut, Baiocchi, Gianluca, Costa, David, Rizoli, Sandro, Balogh, Zsolt J., Bendinelli, Cino, Scalea, Thomas, Ivatury, Rao, Velmahos, George, Andersson, Roland, Kluger, Yoram, Ansaloni, Luca, Catena, Fausto, Di Saverio, Salomone, Podda, Mauro, De Simone, Belinda, Ceresoli, Marco, Augustin, Goran, Gori, Alice, Boermeester, Marja, Sartelli, Massimo, Coccolini, Federico, Tarasconi, Antonio, Angelis, Nicola de, Weber, Dieter G., Tolonen, Matti, Birindelli, Arianna, Biffl, Walter, Moore, Ernest E., Kelly, Michael, Soreide, Kjetil, Kashuk, Jeffry, Ten Broek, Richard, Gomes, Carlos Augusto, Sugrue, Michael, Davies, Richard Justin, Damaskos, Dimitrios, Leppaniemi, Ari, Kirkpatrick, Andrew, Peitzman, Andrew B., Fraga, Gustavo P., Maier, Ronald V., Coimbra, Raul, Chiarugi, Massimo, Sganga, Gabriele, Pisanu, Adolfo, Angelis, Gian Luigi de, Tan, Edward, Van Goor, Harry, Pata, Francesco, Di Carlo, Isidoro, Chiara, Osvaldo, Litvin, Andrey, Campanile, Fabio C., Sakakushev, Boris, Tomadze, Gia, Demetrashvili, Zaza, Latifi, Rifat, Abu-Zidan, Fakri, Romeo, Oreste, Segovia-Lohse, Helmut, Baiocchi, Gianluca, Costa, David, Rizoli, Sandro, Balogh, Zsolt J., Bendinelli, Cino, Scalea, Thomas, Ivatury, Rao, Velmahos, George, Andersson, Roland, Kluger, Yoram, Ansaloni, Luca, and Catena, Fausto
Abstract: Background and aims Acute appendicitis (AA) is among the most common causes of acute abdominal pain. Diagnosis of AA is still challenging and some controversies on its management are still present among different settings and practice patterns worldwide. In July 2015, the World Society of Emergency Surgery (WSES) organized in Jerusalem the first consensus conference on the diagnosis and treatment of AA in adult patients with the intention of producing evidence-based guidelines. An updated consensus conference took place in Nijemegen in June 2019 and the guidelines have now been updated in order to provide evidence-based statements and recommendations in keeping with varying clinical practice: use of clinical scores and imaging in diagnosing AA, indications and timing for surgery, use of non-operative management and antibiotics, laparoscopy and surgical techniques, intra-operative scoring, and peri-operative antibiotic therapy. Methods This executive manuscript summarizes the WSES guidelines for the diagnosis and treatment of AA. Literature search has been updated up to 2019 and statements and recommendations have been developed according to the GRADE methodology. The statements were voted, eventually modified, and finally approved by the participants to the consensus conference and by the board of co-authors, using a Delphi methodology for voting whenever there was controversy on a statement or a recommendation. Several tables highlighting the research topics and questions, search syntaxes, and the statements and the WSES evidence-based recommendations are provided. Finally, two different practical clinical algorithms are provided in the form of a flow chart for both adults and pediatric (< 16 years old) patients. Conclusions The 2020 WSES guidelines on AA aim to provide updated evidence-based statements and recommendations on each of the following topics: (1) diagnosis, (2) non-operative management for uncomplicated AA, (3) timing of appendectomy and in-hosp
Published: 2020
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7. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines

Author: Di Saverio, Salomone, Podda, Mauro, De Simone, Belinda, Ceresoli, Marco, Augustin, Goran, Gori, Alice, Boermeester, Marja, Sartelli, Massimo, Coccolini, Federico, Tarasconi, Antonio, Angelis, Nicola de, Weber, Dieter G., Tolonen, Matti, Birindelli, Arianna, Biffl, Walter, Moore, Ernest E., Kelly, Michael, Soreide, Kjetil, Kashuk, Jeffry, Ten Broek, Richard, Gomes, Carlos Augusto, Sugrue, Michael, Davies, Richard Justin, Damaskos, Dimitrios, Leppaniemi, Ari, Kirkpatrick, Andrew, Peitzman, Andrew B., Fraga, Gustavo P., Maier, Ronald V., Coimbra, Raul, Chiarugi, Massimo, Sganga, Gabriele, Pisanu, Adolfo, Angelis, Gian Luigi de, Tan, Edward, Van Goor, Harry, Pata, Francesco, Di Carlo, Isidoro, Chiara, Osvaldo, Litvin, Andrey, Campanile, Fabio C., Sakakushev, Boris, Tomadze, Gia, Demetrashvili, Zaza, Latifi, Rifat, Abu-Zidan, Fakri, Romeo, Oreste, Segovia-Lohse, Helmut, Baiocchi, Gianluca, Costa, David, Rizoli, Sandro, Balogh, Zsolt J., Bendinelli, Cino, Scalea, Thomas, Ivatury, Rao, Velmahos, George, Andersson, Roland, Kluger, Yoram, Ansaloni, Luca, Catena, Fausto, Di Saverio, Salomone, Podda, Mauro, De Simone, Belinda, Ceresoli, Marco, Augustin, Goran, Gori, Alice, Boermeester, Marja, Sartelli, Massimo, Coccolini, Federico, Tarasconi, Antonio, Angelis, Nicola de, Weber, Dieter G., Tolonen, Matti, Birindelli, Arianna, Biffl, Walter, Moore, Ernest E., Kelly, Michael, Soreide, Kjetil, Kashuk, Jeffry, Ten Broek, Richard, Gomes, Carlos Augusto, Sugrue, Michael, Davies, Richard Justin, Damaskos, Dimitrios, Leppaniemi, Ari, Kirkpatrick, Andrew, Peitzman, Andrew B., Fraga, Gustavo P., Maier, Ronald V., Coimbra, Raul, Chiarugi, Massimo, Sganga, Gabriele, Pisanu, Adolfo, Angelis, Gian Luigi de, Tan, Edward, Van Goor, Harry, Pata, Francesco, Di Carlo, Isidoro, Chiara, Osvaldo, Litvin, Andrey, Campanile, Fabio C., Sakakushev, Boris, Tomadze, Gia, Demetrashvili, Zaza, Latifi, Rifat, Abu-Zidan, Fakri, Romeo, Oreste, Segovia-Lohse, Helmut, Baiocchi, Gianluca, Costa, David, Rizoli, Sandro, Balogh, Zsolt J., Bendinelli, Cino, Scalea, Thomas, Ivatury, Rao, Velmahos, George, Andersson, Roland, Kluger, Yoram, Ansaloni, Luca, and Catena, Fausto
Abstract: Background and aims Acute appendicitis (AA) is among the most common causes of acute abdominal pain. Diagnosis of AA is still challenging and some controversies on its management are still present among different settings and practice patterns worldwide. In July 2015, the World Society of Emergency Surgery (WSES) organized in Jerusalem the first consensus conference on the diagnosis and treatment of AA in adult patients with the intention of producing evidence-based guidelines. An updated consensus conference took place in Nijemegen in June 2019 and the guidelines have now been updated in order to provide evidence-based statements and recommendations in keeping with varying clinical practice: use of clinical scores and imaging in diagnosing AA, indications and timing for surgery, use of non-operative management and antibiotics, laparoscopy and surgical techniques, intra-operative scoring, and peri-operative antibiotic therapy. Methods This executive manuscript summarizes the WSES guidelines for the diagnosis and treatment of AA. Literature search has been updated up to 2019 and statements and recommendations have been developed according to the GRADE methodology. The statements were voted, eventually modified, and finally approved by the participants to the consensus conference and by the board of co-authors, using a Delphi methodology for voting whenever there was controversy on a statement or a recommendation. Several tables highlighting the research topics and questions, search syntaxes, and the statements and the WSES evidence-based recommendations are provided. Finally, two different practical clinical algorithms are provided in the form of a flow chart for both adults and pediatric (< 16 years old) patients. Conclusions The 2020 WSES guidelines on AA aim to provide updated evidence-based statements and recommendations on each of the following topics: (1) diagnosis, (2) non-operative management for uncomplicated AA, (3) timing of appendectomy and in-hosp
Published: 2020
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8. WSES Guidelines for the management of acute left sided colonic diverticulitis in the emergency setting

Author: Sartelli, Massimo, Catena, Fausto, Ansaloni, Luca, Coccolini, Federico, Griffiths, Ewen A., Abu-Zidan, Fikri M., Di Saverio, Salomone, Ulrych, Jan, Kluger, Yoram, Ben-Ishay, Ofir, Moore, Frederick A., Ivatury, Rao R., Coimbra, Raul, Peitzman, Andrew B., Leppaniemi, Ari, Fraga, Gustavo P., Maier, Ronald V., Chiara, Osvaldo, Kashuk, Jeffry, Sakakushev, Boris, Weber, Dieter G., Latifi, Rifat, Biffl, Walter, Bala, Miklosh, Karamarkovic, Aleksandar, Inaba, Kenji, Ordonez, Carlos A., Hecker, Andreas, Augustin, Goran, Demetrashvili, Zaza, Melo, Renato Bessa, Marwah, Sanjay, Zachariah, Sanoop K., Shelat, Vishal G., McFarlane, Michael, Rems, Miran, Gomes, Carlos Augusto, Faro, Mario Paulo, Júnior, Gerson Alves Pereira, Negoi, Ionut, Cui, Yunfeng, Sato, Norio, Vereczkei, Andras, Bellanova, Giovanni, Birindelli, Arianna, Di Carlo, Isidoro, Kok, Kenneth Y, Gachabayov, Mahir, Gkiokas, Georgios, Bouliaris, Konstantinos, Çolak, Elif, Isik, Arda, Rios-Cruz, Daniel, Soto, Rodolfo, Moore, Ernest E., Sartelli, Massimo, Catena, Fausto, Ansaloni, Luca, Coccolini, Federico, Griffiths, Ewen A., Abu-Zidan, Fikri M., Di Saverio, Salomone, Ulrych, Jan, Kluger, Yoram, Ben-Ishay, Ofir, Moore, Frederick A., Ivatury, Rao R., Coimbra, Raul, Peitzman, Andrew B., Leppaniemi, Ari, Fraga, Gustavo P., Maier, Ronald V., Chiara, Osvaldo, Kashuk, Jeffry, Sakakushev, Boris, Weber, Dieter G., Latifi, Rifat, Biffl, Walter, Bala, Miklosh, Karamarkovic, Aleksandar, Inaba, Kenji, Ordonez, Carlos A., Hecker, Andreas, Augustin, Goran, Demetrashvili, Zaza, Melo, Renato Bessa, Marwah, Sanjay, Zachariah, Sanoop K., Shelat, Vishal G., McFarlane, Michael, Rems, Miran, Gomes, Carlos Augusto, Faro, Mario Paulo, Júnior, Gerson Alves Pereira, Negoi, Ionut, Cui, Yunfeng, Sato, Norio, Vereczkei, Andras, Bellanova, Giovanni, Birindelli, Arianna, Di Carlo, Isidoro, Kok, Kenneth Y, Gachabayov, Mahir, Gkiokas, Georgios, Bouliaris, Konstantinos, Çolak, Elif, Isik, Arda, Rios-Cruz, Daniel, Soto, Rodolfo, and Moore, Ernest E.
Abstract: Acute left sided colonic diverticulitis is one of the most common clinical conditions encountered by surgeons in acute setting. A World Society of Emergency Surgery (WSES) Consensus Conference on acute diverticulitis was held during the 3rd World Congress of the WSES in Jerusalem, Israel, on July 7th, 2015. During this consensus conference the guidelines for the management of acute left sided colonic diverticulitis in the emergency setting were presented and discussed. This document represents the executive summary of the final guidelines approved by the consensus conference.
Published: 2016

9. WSES Jerusalem guidelines for diagnosis and treatment of acute appendicitis

Author: Di Saverio, Salomone, Birindelli, Arianna, Kelly, Micheal D., Catena, Fausto, Weber, Dieter G., Sartelli, Massimo, Sugrue, Michael, De Moya, Mark, Augusto Gomes, Carlos, Bhangu, Aneel, Agresta, Ferdinando, Moore, Ernest E., Soreide, Kjetil, Griffiths, Ewen, De Castro, Steve, Kashuk, Jeffry, Kluger, Yoram, Leppaniemi, Ari, Ansaloni, Luca, Andersson, Manne, Coccolini, Federico, Coimbra, Raul, Gurusamy, Kurinchi S., Cesare Campanile, Fabio, Biffl, Walter, Chiara, Osvaldo, Moore, Fred, Peitzman, Andrew B., Fraga, Gustavo P., Costa, David, Maier, Ronald V., Rizoli, Sandro, Balogh, Zsolt J., Bendinelli, Cino, Cirocchi, Roberto, Tonini, Valeria, Piccinini, Alice, Tugnoli, Gregorio, Jovine, Elio, Persiani, Roberto, Biondi, Antonio, Scalea, Thomas, Stahel, Philip, Ivatury, Rao, Velmahos, George, Andersson, Roland, Di Saverio, Salomone, Birindelli, Arianna, Kelly, Micheal D., Catena, Fausto, Weber, Dieter G., Sartelli, Massimo, Sugrue, Michael, De Moya, Mark, Augusto Gomes, Carlos, Bhangu, Aneel, Agresta, Ferdinando, Moore, Ernest E., Soreide, Kjetil, Griffiths, Ewen, De Castro, Steve, Kashuk, Jeffry, Kluger, Yoram, Leppaniemi, Ari, Ansaloni, Luca, Andersson, Manne, Coccolini, Federico, Coimbra, Raul, Gurusamy, Kurinchi S., Cesare Campanile, Fabio, Biffl, Walter, Chiara, Osvaldo, Moore, Fred, Peitzman, Andrew B., Fraga, Gustavo P., Costa, David, Maier, Ronald V., Rizoli, Sandro, Balogh, Zsolt J., Bendinelli, Cino, Cirocchi, Roberto, Tonini, Valeria, Piccinini, Alice, Tugnoli, Gregorio, Jovine, Elio, Persiani, Roberto, Biondi, Antonio, Scalea, Thomas, Stahel, Philip, Ivatury, Rao, Velmahos, George, and Andersson, Roland
Abstract: Acute appendicitis (AA) is among the most common cause of acute abdominal pain. Diagnosis of AA is challenging; a variable combination of clinical signs and symptoms has been used together with laboratory findings in several scoring systems proposed for suggesting the probability of AA and the possible subsequent management pathway. The role of imaging in the diagnosis of AA is still debated, with variable use of US, CT and MRI in different settings worldwide. Up to date, comprehensive clinical guidelines for diagnosis and management of AA have never been issued. In July 2015, during the 3rd World Congress of the WSES, held in Jerusalem (Israel), a panel of experts including an Organizational Committee and Scientific Committee and Scientific Secretariat, participated to a Consensus Conference where eight panelists presented a number of statements developed for each of the eight main questions about diagnosis and management of AA. The statements were then voted, eventually modified and finally approved by the participants to The Consensus Conference and lately by the board of co-authors. The current paper is reporting the definitive Guidelines Statements on each of the following topics: 1) Diagnostic efficiency of clinical scoring systems, 2) Role of Imaging, 3) Non-operative treatment for uncomplicated appendicitis, 4) Timing of appendectomy and in-hospital delay, 5) Surgical treatment 6) Scoring systems for intra-operative grading of appendicitis and their clinical usefulness 7) Non-surgical treatment for complicated appendicitis: abscess or phlegmon 8) Pre-operative and post-operative antibiotics.
Published: 2016
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10. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA).

Author: UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs, Sartelli, Massimo, Weber, Dieter G, Ruppé, Etienne, Bassetti, Matteo, Wright, Brian J, Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M, Coimbra, Raul, Moore, Ernest E, Moore, Frederick A, Maier, Ronald V, De Waele, Jan J, Kirkpatrick, Andrew W, Griffiths, Ewen A, Eckmann, Christian, Brink, Adrian J, Mazuski, John E, May, Addison K, Sawyer, Rob G, Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A, Vincent, Jean-Louis, Watkins, Richard R, Lowman, Warren, Spellberg, Brad, Abbott, Iain J, Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N, Agresta, Ferdinando, Althani, Asma A, Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J, Baraket, Oussama, Bhangu, Aneel, Beltrán, Marcelo A, Bernhard, Michael, Biffl, Walter L, Boermeester, Marja A, Brecher, Stephen M, Cherry-Bukowiec, Jill R, Buyne, Otmar R, Cainzos, Miguel A, Cairns, Kelly A, Camacho-Ortiz, Adrian, Chandy, Sujith J, Che Jusoh, Asri, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, José J, Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P, Dorj, Gereltuya, Dogjani, Agron, Dupont, Hervé, Eachempati, Soumitra R, Enani, Mushira Abdulaziz, Egiev, Valery N, Elmangory, Mutasim M, Ferrada, Paula, Fitchett, Joseph R, Fraga, Gustavo P, Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R, Gomes, Carlos Augusto, Gomi, Harumi, Guzmán-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R, Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J, Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G, Kenig, Jakub, Kiguba, Ronald, Kim, Peter K, Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y Y, Kong, Victory, Knox, Matthew C, Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R, Labbate, Maurizio, Labricciosa, Francesco M, Laterre, Pierre-François, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y, Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E, Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P, Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H, Ordonez, Carlos A, Ouadii, Mouaqit, Pereira Júnior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Segovia Lohse, Helmut A, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G, Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V, Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S, Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K, Zahar, Jean-Ralph, Zakrison, Tanya L, Corcione, Antonio, Melotti, Rita M, Viscoli, Claudio, Viale, Perluigi, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs, Sartelli, Massimo, Weber, Dieter G, Ruppé, Etienne, Bassetti, Matteo, Wright, Brian J, Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M, Coimbra, Raul, Moore, Ernest E, Moore, Frederick A, Maier, Ronald V, De Waele, Jan J, Kirkpatrick, Andrew W, Griffiths, Ewen A, Eckmann, Christian, Brink, Adrian J, Mazuski, John E, May, Addison K, Sawyer, Rob G, Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A, Vincent, Jean-Louis, Watkins, Richard R, Lowman, Warren, Spellberg, Brad, Abbott, Iain J, Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N, Agresta, Ferdinando, Althani, Asma A, Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J, Baraket, Oussama, Bhangu, Aneel, Beltrán, Marcelo A, Bernhard, Michael, Biffl, Walter L, Boermeester, Marja A, Brecher, Stephen M, Cherry-Bukowiec, Jill R, Buyne, Otmar R, Cainzos, Miguel A, Cairns, Kelly A, Camacho-Ortiz, Adrian, Chandy, Sujith J, Che Jusoh, Asri, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, José J, Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P, Dorj, Gereltuya, Dogjani, Agron, Dupont, Hervé, Eachempati, Soumitra R, Enani, Mushira Abdulaziz, Egiev, Valery N, Elmangory, Mutasim M, Ferrada, Paula, Fitchett, Joseph R, Fraga, Gustavo P, Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R, Gomes, Carlos Augusto, Gomi, Harumi, Guzmán-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R, Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J, Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G, Kenig, Jakub, Kiguba, Ronald, Kim, Peter K, Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y Y, Kong, Victory, Knox, Matthew C, Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R, Labbate, Maurizio, Labricciosa, Francesco M, Laterre, Pierre-François, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y, Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E, Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P, Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H, Ordonez, Carlos A, Ouadii, Mouaqit, Pereira Júnior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Segovia Lohse, Helmut A, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G, Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V, Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S, Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K, Zahar, Jean-Ralph, Zakrison, Tanya L, Corcione, Antonio, Melotti, Rita M, Viscoli, Claudio, and Viale, Perluigi
Abstract: Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.
Published: 2016

11. WSES Guidelines for the management of acute left sided colonic diverticulitis in the emergency setting

Author: University of Helsinki, II kirurgian klinikka, Sartelli, Massimo, Catena, Fausto, Ansaloni, Luca, Coccolini, Federico, Griffiths, Ewen A., Abu-Zidan, Fikri M., Di Saverio, Salomone, Ulrych, Jan, Kluger, Yoram, Ben-Ishay, Ofir, Moore, Frederick A., Ivatury, Rao R., Coimbra, Raul, Peitzman, Andrew B., Leppäniemi, Ari, Fraga, Gustavo P., Maier, Ronald V., Chiara, Osvaldo, Kashuk, Jeffry, Sakakushev, Boris, Weber, Dieter G., Latifi, Rifat, Biffl, Walter, Bala, Miklosh, Karamarkovic, Aleksandar, Inaba, Kenji, Ordonez, Carlos A., Hecker, Andreas, Augustin, Goran, Demetrashvili, Zaza, Melo, Renato Bessa, Marwah, Sanjay, Zachariah, Sanoop K., Shelat, Vishal G., McFarlane, Michael, Rems, Miran, Gomes, Carlos Augusto, Faro, Mario Paulo, Pereira Junior, Gerson Alves, Negoi, Ionut, Cui, Yunfeng, Sato, Norio, Vereczkei, Andras, Bellanova, Giovanni, Birindelli, Arianna, Di Carlo, Isidoro, Kok, Kenneth Y., Gachabayov, Mahir, Gkiokas, Georgios, Bouliaris, Konstantinos, Colak, Elif, Isik, Arda, Rios-Cruz, Daniel, Soto, Rodolfo, Moore, Ernest E., University of Helsinki, II kirurgian klinikka, Sartelli, Massimo, Catena, Fausto, Ansaloni, Luca, Coccolini, Federico, Griffiths, Ewen A., Abu-Zidan, Fikri M., Di Saverio, Salomone, Ulrych, Jan, Kluger, Yoram, Ben-Ishay, Ofir, Moore, Frederick A., Ivatury, Rao R., Coimbra, Raul, Peitzman, Andrew B., Leppäniemi, Ari, Fraga, Gustavo P., Maier, Ronald V., Chiara, Osvaldo, Kashuk, Jeffry, Sakakushev, Boris, Weber, Dieter G., Latifi, Rifat, Biffl, Walter, Bala, Miklosh, Karamarkovic, Aleksandar, Inaba, Kenji, Ordonez, Carlos A., Hecker, Andreas, Augustin, Goran, Demetrashvili, Zaza, Melo, Renato Bessa, Marwah, Sanjay, Zachariah, Sanoop K., Shelat, Vishal G., McFarlane, Michael, Rems, Miran, Gomes, Carlos Augusto, Faro, Mario Paulo, Pereira Junior, Gerson Alves, Negoi, Ionut, Cui, Yunfeng, Sato, Norio, Vereczkei, Andras, Bellanova, Giovanni, Birindelli, Arianna, Di Carlo, Isidoro, Kok, Kenneth Y., Gachabayov, Mahir, Gkiokas, Georgios, Bouliaris, Konstantinos, Colak, Elif, Isik, Arda, Rios-Cruz, Daniel, Soto, Rodolfo, and Moore, Ernest E.
Abstract: Acute left sided colonic diverticulitis is one of the most common clinical conditions encountered by surgeons in acute setting. A World Society of Emergency Surgery (WSES) Consensus Conference on acute diverticulitis was held during the 3rd World Congress of the WSES in Jerusalem, Israel, on July 7th, 2015. During this consensus conference the guidelines for the management of acute left sided colonic diverticulitis in the emergency setting were presented and discussed. This document represents the executive summary of the final guidelines approved by the consensus conference.
Published: 2016

12. Antimicrobials

Author: University of Helsinki, II kirurgian klinikka, Sartelli, Massimo, Weber, Dieter G., Ruppe, Etienne, Bassetti, Matteo, Wright, Brian J., Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M., Coimbra, Raul, Moore, Ernest E., Moore, Frederick A., Maier, Ronald V., De Waele, Jan J., Kirkpatrick, Andrew W., Griffiths, Ewen A., Eckmann, Christian, Brink, Adrian J., Mazuski, John E., May, Addison K., Sawyer, Rob G., Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A., Vincent, Jean-Louis, Watkins, Richard R., Lowman, Warren, Spellberg, Brad, Abbott, Iain J., Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N., Agresta, Ferdinando, Althani, Asma A., Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussama, Bhangu, Aneel, Beltran, Marcelo A., Bernhard, Michael, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Cherry-Bukowiec, Jill R., Buyne, Otmar R., Cainzos, Miguel A., Cairns, Kelly A., Camacho-Ortiz, Adrian, Chandy, Sujith J., Jusoh, Asri Che, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P., Dorj, Gereltuya, Dogjani, Agron, Dupont, Herve, Eachempati, Soumitra R., Enani, Mushira Abdulaziz, Egiev, Valery N., Elmangory, Mutasim M., Ferrada, Paula, Fitchett, Joseph R., Fraga, Gustavo P., Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R., Gomes, Carlos Augusto, Gomi, Harumi, Guzman-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R., Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G., Kenig, Jakub, Kiguba, Ronald, Kim, Peter K., Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y. Y., Kong, Victory, Knox, Matthew C., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R., Labbate, Maurizio, Labricciosa, Francesco M., Laterre, Pierre-Francois, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppäniemi, Ari, Li, Yousheng, Liang, Stephen Y., Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E., Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P., Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Pereira Junior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Lohse, Helmut A. Segovia, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G., Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V., Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S., Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean-Ralph, Zakrison, Tanya L., Corcione, Antonio, Melotti, Rita M., Viscoli, Claudio, Viale, Perluigi, University of Helsinki, II kirurgian klinikka, Sartelli, Massimo, Weber, Dieter G., Ruppe, Etienne, Bassetti, Matteo, Wright, Brian J., Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M., Coimbra, Raul, Moore, Ernest E., Moore, Frederick A., Maier, Ronald V., De Waele, Jan J., Kirkpatrick, Andrew W., Griffiths, Ewen A., Eckmann, Christian, Brink, Adrian J., Mazuski, John E., May, Addison K., Sawyer, Rob G., Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A., Vincent, Jean-Louis, Watkins, Richard R., Lowman, Warren, Spellberg, Brad, Abbott, Iain J., Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N., Agresta, Ferdinando, Althani, Asma A., Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussama, Bhangu, Aneel, Beltran, Marcelo A., Bernhard, Michael, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Cherry-Bukowiec, Jill R., Buyne, Otmar R., Cainzos, Miguel A., Cairns, Kelly A., Camacho-Ortiz, Adrian, Chandy, Sujith J., Jusoh, Asri Che, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P., Dorj, Gereltuya, Dogjani, Agron, Dupont, Herve, Eachempati, Soumitra R., Enani, Mushira Abdulaziz, Egiev, Valery N., Elmangory, Mutasim M., Ferrada, Paula, Fitchett, Joseph R., Fraga, Gustavo P., Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R., Gomes, Carlos Augusto, Gomi, Harumi, Guzman-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R., Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G., Kenig, Jakub, Kiguba, Ronald, Kim, Peter K., Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y. Y., Kong, Victory, Knox, Matthew C., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R., Labbate, Maurizio, Labricciosa, Francesco M., Laterre, Pierre-Francois, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppäniemi, Ari, Li, Yousheng, Liang, Stephen Y., Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E., Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P., Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Pereira Junior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Lohse, Helmut A. Segovia, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G., Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V., Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S., Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean-Ralph, Zakrison, Tanya L., Corcione, Antonio, Melotti, Rita M., Viscoli, Claudio, and Viale, Perluigi
Abstract: Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.
Published: 2016

13. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Author: Sartelli, Massimo, Weber, Dieter G., Ruppe, Etienne, Bassetti, Matteo, Wright, Brian J., Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M., Coimbra, Raul, Moore, Ernest E., Moore, Frederick A., Maier, Ronald V., De Waele, Jan J., Kirkpatrick, Andrew W., Griffiths, Ewen A., Eckmann, Christian, Brink, Adrian J., Mazuski, John E., May, Addison K., Sawyer, Rob G., Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A., Vincent, Jean-Louis, Watkins, Richard R., Lowman, Warren, Spellberg, Brad, Abbott, Iain J., Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N., Agresta, Ferdinando, Althani, Asma A., Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussama, Bhangu, Aneel, Beltran, Marcelo A., Bernhard, Michael, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Cherry-Bukowiec, Jill R., Buyne, Otmar R., Cainzos, Miguel A., Cairns, Kelly A., Camacho-Ortiz, Adrian, Chandy, Sujith J., Jusoh, Asri Che, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P., Dorj, Gereltuya, Dogjani, Agron, Dupont, Herve, Eachempati, Soumitra R., Enani, Mushira Abdulaziz, Egiev, Valery N., Elmangory, Mutasim M., Ferrada, Paula, Fitchett, Joseph R., Fraga, Gustavo P., Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R., Gomes, Carlos Augusto, Gomi, Harumi, Guzman-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R., Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G., Kenig, Jakub, Kiguba, Ronald, Kim, Peter K., Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y. Y., Kong, Victory, Knox, Matthew C., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R., Labbate, Maurizio, Labricciosa, Francesco M., Laterre, Pierre-Francois, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y., Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E., Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P., Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Pereira Junior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Lohse, Helmut A. Segovia, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G., Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V., Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S., Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean-Ralph, Zakrison, Tanya L., Corcione, Antonio, Melotti, Rita M., Viscoli, Claudio, Viale, Perluigi, Sartelli, Massimo, Weber, Dieter G., Ruppe, Etienne, Bassetti, Matteo, Wright, Brian J., Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M., Coimbra, Raul, Moore, Ernest E., Moore, Frederick A., Maier, Ronald V., De Waele, Jan J., Kirkpatrick, Andrew W., Griffiths, Ewen A., Eckmann, Christian, Brink, Adrian J., Mazuski, John E., May, Addison K., Sawyer, Rob G., Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A., Vincent, Jean-Louis, Watkins, Richard R., Lowman, Warren, Spellberg, Brad, Abbott, Iain J., Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N., Agresta, Ferdinando, Althani, Asma A., Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussama, Bhangu, Aneel, Beltran, Marcelo A., Bernhard, Michael, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Cherry-Bukowiec, Jill R., Buyne, Otmar R., Cainzos, Miguel A., Cairns, Kelly A., Camacho-Ortiz, Adrian, Chandy, Sujith J., Jusoh, Asri Che, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P., Dorj, Gereltuya, Dogjani, Agron, Dupont, Herve, Eachempati, Soumitra R., Enani, Mushira Abdulaziz, Egiev, Valery N., Elmangory, Mutasim M., Ferrada, Paula, Fitchett, Joseph R., Fraga, Gustavo P., Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R., Gomes, Carlos Augusto, Gomi, Harumi, Guzman-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R., Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G., Kenig, Jakub, Kiguba, Ronald, Kim, Peter K., Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y. Y., Kong, Victory, Knox, Matthew C., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R., Labbate, Maurizio, Labricciosa, Francesco M., Laterre, Pierre-Francois, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y., Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E., Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P., Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Pereira Junior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Lohse, Helmut A. Segovia, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G., Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V., Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S., Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean-Ralph, Zakrison, Tanya L., Corcione, Antonio, Melotti, Rita M., Viscoli, Claudio, and Viale, Perluigi
Abstract: Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.
Published: 2016

14. WSES Jerusalem guidelines for diagnosis and treatment of acute appendicitis

Author: Di Saverio, Salomone, Birindelli, Arianna, Kelly, Micheal D., Catena, Fausto, Weber, Dieter G., Sartelli, Massimo, Sugrue, Michael, De Moya, Mark, Augusto Gomes, Carlos, Bhangu, Aneel, Agresta, Ferdinando, Moore, Ernest E., Soreide, Kjetil, Griffiths, Ewen, De Castro, Steve, Kashuk, Jeffry, Kluger, Yoram, Leppaniemi, Ari, Ansaloni, Luca, Andersson, Manne, Coccolini, Federico, Coimbra, Raul, Gurusamy, Kurinchi S., Cesare Campanile, Fabio, Biffl, Walter, Chiara, Osvaldo, Moore, Fred, Peitzman, Andrew B., Fraga, Gustavo P., Costa, David, Maier, Ronald V., Rizoli, Sandro, Balogh, Zsolt J., Bendinelli, Cino, Cirocchi, Roberto, Tonini, Valeria, Piccinini, Alice, Tugnoli, Gregorio, Jovine, Elio, Persiani, Roberto, Biondi, Antonio, Scalea, Thomas, Stahel, Philip, Ivatury, Rao, Velmahos, George, Andersson, Roland, Di Saverio, Salomone, Birindelli, Arianna, Kelly, Micheal D., Catena, Fausto, Weber, Dieter G., Sartelli, Massimo, Sugrue, Michael, De Moya, Mark, Augusto Gomes, Carlos, Bhangu, Aneel, Agresta, Ferdinando, Moore, Ernest E., Soreide, Kjetil, Griffiths, Ewen, De Castro, Steve, Kashuk, Jeffry, Kluger, Yoram, Leppaniemi, Ari, Ansaloni, Luca, Andersson, Manne, Coccolini, Federico, Coimbra, Raul, Gurusamy, Kurinchi S., Cesare Campanile, Fabio, Biffl, Walter, Chiara, Osvaldo, Moore, Fred, Peitzman, Andrew B., Fraga, Gustavo P., Costa, David, Maier, Ronald V., Rizoli, Sandro, Balogh, Zsolt J., Bendinelli, Cino, Cirocchi, Roberto, Tonini, Valeria, Piccinini, Alice, Tugnoli, Gregorio, Jovine, Elio, Persiani, Roberto, Biondi, Antonio, Scalea, Thomas, Stahel, Philip, Ivatury, Rao, Velmahos, George, and Andersson, Roland
Abstract: Acute appendicitis (AA) is among the most common cause of acute abdominal pain. Diagnosis of AA is challenging; a variable combination of clinical signs and symptoms has been used together with laboratory findings in several scoring systems proposed for suggesting the probability of AA and the possible subsequent management pathway. The role of imaging in the diagnosis of AA is still debated, with variable use of US, CT and MRI in different settings worldwide. Up to date, comprehensive clinical guidelines for diagnosis and management of AA have never been issued. In July 2015, during the 3rd World Congress of the WSES, held in Jerusalem (Israel), a panel of experts including an Organizational Committee and Scientific Committee and Scientific Secretariat, participated to a Consensus Conference where eight panelists presented a number of statements developed for each of the eight main questions about diagnosis and management of AA. The statements were then voted, eventually modified and finally approved by the participants to The Consensus Conference and lately by the board of co-authors. The current paper is reporting the definitive Guidelines Statements on each of the following topics: 1) Diagnostic efficiency of clinical scoring systems, 2) Role of Imaging, 3) Non-operative treatment for uncomplicated appendicitis, 4) Timing of appendectomy and in-hospital delay, 5) Surgical treatment 6) Scoring systems for intra-operative grading of appendicitis and their clinical usefulness 7) Non-surgical treatment for complicated appendicitis: abscess or phlegmon 8) Pre-operative and post-operative antibiotics.
Published: 2016
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15. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Author: Sartelli, Massimo, Weber, Dieter G., Ruppe, Etienne, Bassetti, Matteo, Wright, Brian J., Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M., Coimbra, Raul, Moore, Ernest E., Moore, Frederick A., Maier, Ronald V., De Waele, Jan J., Kirkpatrick, Andrew W., Griffiths, Ewen A., Eckmann, Christian, Brink, Adrian J., Mazuski, John E., May, Addison K., Sawyer, Rob G., Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A., Vincent, Jean-Louis, Watkins, Richard R., Lowman, Warren, Spellberg, Brad, Abbott, Iain J., Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N., Agresta, Ferdinando, Althani, Asma A., Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussama, Bhangu, Aneel, Beltran, Marcelo A., Bernhard, Michael, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Cherry-Bukowiec, Jill R., Buyne, Otmar R., Cainzos, Miguel A., Cairns, Kelly A., Camacho-Ortiz, Adrian, Chandy, Sujith J., Jusoh, Asri Che, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P., Dorj, Gereltuya, Dogjani, Agron, Dupont, Herve, Eachempati, Soumitra R., Enani, Mushira Abdulaziz, Egiev, Valery N., Elmangory, Mutasim M., Ferrada, Paula, Fitchett, Joseph R., Fraga, Gustavo P., Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R., Gomes, Carlos Augusto, Gomi, Harumi, Guzman-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R., Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G., Kenig, Jakub, Kiguba, Ronald, Kim, Peter K., Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y. Y., Kong, Victory, Knox, Matthew C., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R., Labbate, Maurizio, Labricciosa, Francesco M., Laterre, Pierre-Francois, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y., Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E., Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P., Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Pereira Junior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Lohse, Helmut A. Segovia, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G., Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V., Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S., Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean-Ralph, Zakrison, Tanya L., Corcione, Antonio, Melotti, Rita M., Viscoli, Claudio, Viale, Perluigi, Sartelli, Massimo, Weber, Dieter G., Ruppe, Etienne, Bassetti, Matteo, Wright, Brian J., Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M., Coimbra, Raul, Moore, Ernest E., Moore, Frederick A., Maier, Ronald V., De Waele, Jan J., Kirkpatrick, Andrew W., Griffiths, Ewen A., Eckmann, Christian, Brink, Adrian J., Mazuski, John E., May, Addison K., Sawyer, Rob G., Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A., Vincent, Jean-Louis, Watkins, Richard R., Lowman, Warren, Spellberg, Brad, Abbott, Iain J., Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N., Agresta, Ferdinando, Althani, Asma A., Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussama, Bhangu, Aneel, Beltran, Marcelo A., Bernhard, Michael, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Cherry-Bukowiec, Jill R., Buyne, Otmar R., Cainzos, Miguel A., Cairns, Kelly A., Camacho-Ortiz, Adrian, Chandy, Sujith J., Jusoh, Asri Che, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P., Dorj, Gereltuya, Dogjani, Agron, Dupont, Herve, Eachempati, Soumitra R., Enani, Mushira Abdulaziz, Egiev, Valery N., Elmangory, Mutasim M., Ferrada, Paula, Fitchett, Joseph R., Fraga, Gustavo P., Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R., Gomes, Carlos Augusto, Gomi, Harumi, Guzman-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R., Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G., Kenig, Jakub, Kiguba, Ronald, Kim, Peter K., Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y. Y., Kong, Victory, Knox, Matthew C., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R., Labbate, Maurizio, Labricciosa, Francesco M., Laterre, Pierre-Francois, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y., Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E., Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P., Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Pereira Junior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Lohse, Helmut A. Segovia, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G., Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V., Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S., Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean-Ralph, Zakrison, Tanya L., Corcione, Antonio, Melotti, Rita M., Viscoli, Claudio, and Viale, Perluigi
Abstract: Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.
Published: 2016

16. Erratum to: 2016 WSES guidelines on acute calculous cholecystitis

Author: Ansaloni, Luca, Pisano, Michele, Coccolini, Federico, Peitzmann, Andrew B., Fingerhut, Abe, Catena, Fausto, Agresta, Ferdinando, Allegri, Andrea, Bailey, Ian, Balogh, Zsolt J., Bendinelli, Cino, Biffl, Walter, Bonavina, Luigi, Borzellino, Giuseppe, Brunetti, Francesco, Burlew, Clay Cothren, Camapanelli, Giampiero, Campanile, Fabio Cesare, Ceresoli, Marco, Chiara, Osvaldo, Civil, Ian, Coimbra, Raul, De Moya, Marc, Di Saverio, Salomone, Fraga, Gustavo Pereira, Gupta, Sanjay, Kashuk, Jeffry L., Kelly, Michael Denis, Khokha, Vladimir, Jeekel, Hans, Latifi, Rifat, Leppäniemi, Ari Kalevi, Maier, Ronald V., Marzi, Ingo, Moore, Frederick Alan, Piazzalunga, Dario, Sakakushev, Boris, Sartelli, Massimo, Scalea, Thomas, Stahel, Philip F., Taviloglu, Korhan, Tugnoli, Gregorio, Uranüs, Selman, Velmahos, George C., Wani, Imtiaz, Weber, Dieter G., Viale, Pierluigi, Sugrue, Michael, Ivatury, Rao, Kluger, Yoram, Gurusamy, Kurinchi S., Moore, Ernest E., Ansaloni, Luca, Pisano, Michele, Coccolini, Federico, Peitzmann, Andrew B., Fingerhut, Abe, Catena, Fausto, Agresta, Ferdinando, Allegri, Andrea, Bailey, Ian, Balogh, Zsolt J., Bendinelli, Cino, Biffl, Walter, Bonavina, Luigi, Borzellino, Giuseppe, Brunetti, Francesco, Burlew, Clay Cothren, Camapanelli, Giampiero, Campanile, Fabio Cesare, Ceresoli, Marco, Chiara, Osvaldo, Civil, Ian, Coimbra, Raul, De Moya, Marc, Di Saverio, Salomone, Fraga, Gustavo Pereira, Gupta, Sanjay, Kashuk, Jeffry L., Kelly, Michael Denis, Khokha, Vladimir, Jeekel, Hans, Latifi, Rifat, Leppäniemi, Ari Kalevi, Maier, Ronald V., Marzi, Ingo, Moore, Frederick Alan, Piazzalunga, Dario, Sakakushev, Boris, Sartelli, Massimo, Scalea, Thomas, Stahel, Philip F., Taviloglu, Korhan, Tugnoli, Gregorio, Uranüs, Selman, Velmahos, George C., Wani, Imtiaz, Weber, Dieter G., Viale, Pierluigi, Sugrue, Michael, Ivatury, Rao, Kluger, Yoram, Gurusamy, Kurinchi S., and Moore, Ernest E.
Abstract: Unfortunately, the original version of this article contained an error in the spelling of an author’s name. The surname is written as Koka, but should be spelt as Khokha.
Published: 2016

17. 2016 WSES guidelines on acute calculous cholecystitis

Author: Ansaloni, Luca, Pisano, Michele, Coccolini, Federico, Peitzmann, Andrew B., Fingerhut, Abe, Catena, Fausto, Agresta, Ferdinando, Allegri, Andrea, Bailey, Ian, Balogh, Zsolt J., Bendinelli, Cino, Biffl, Walter, Bonavina, Luigi, Borzellino, Giuseppe, Brunetti, Francesco, Burlew, Clay Cothren, Camapanelli, Giampiero, Campanile, Fabio Cesare, Ceresoli, Marco, Chiara, Osvaldo, Civil, Ian, Coimbra, Raul, De Moya, Marc, Di Saverio, Salomone, Fraga, Gustavo Pereira, Gupta, Sanjay, Kashuk, Jeffry L., Kelly, Michael Denis, Khokha, Vladimir, Jeekel, Hans, Latifi, Rifat, Leppäniemi, Ari Kalevi, Maier, Ronald V., Marzi, Ingo, Moore, Frederick Alan, Piazzalunga, Dario, Sakakushev, Boris, Sartelli, Massimo, Scalea, Thomas, Stahel, Philip F., Taviloglu, Korhan, Tugnoli, Gregorio, Uranüs, Selman, Velmahos, George C., Wani, Imtiaz, Weber, Dieter G., Viale, Pierluigi, Sugrue, Michael, Ivatury, Rao, Kluger, Yoram, Gurusamy, Kurinchi S., Moore, Ernest E., Ansaloni, Luca, Pisano, Michele, Coccolini, Federico, Peitzmann, Andrew B., Fingerhut, Abe, Catena, Fausto, Agresta, Ferdinando, Allegri, Andrea, Bailey, Ian, Balogh, Zsolt J., Bendinelli, Cino, Biffl, Walter, Bonavina, Luigi, Borzellino, Giuseppe, Brunetti, Francesco, Burlew, Clay Cothren, Camapanelli, Giampiero, Campanile, Fabio Cesare, Ceresoli, Marco, Chiara, Osvaldo, Civil, Ian, Coimbra, Raul, De Moya, Marc, Di Saverio, Salomone, Fraga, Gustavo Pereira, Gupta, Sanjay, Kashuk, Jeffry L., Kelly, Michael Denis, Khokha, Vladimir, Jeekel, Hans, Latifi, Rifat, Leppäniemi, Ari Kalevi, Maier, Ronald V., Marzi, Ingo, Moore, Frederick Alan, Piazzalunga, Dario, Sakakushev, Boris, Sartelli, Massimo, Scalea, Thomas, Stahel, Philip F., Taviloglu, Korhan, Tugnoli, Gregorio, Uranüs, Selman, Velmahos, George C., Wani, Imtiaz, Weber, Dieter G., Viale, Pierluigi, Sugrue, Michael, Ivatury, Rao, Kluger, Yoram, Gurusamy, Kurinchi S., and Moore, Ernest E.
Abstract: Acute calculus cholecystitis is a very common disease with several area of uncertainty. The World Society of Emergency Surgery developed extensive guidelines in order to cover grey areas. The diagnostic criteria, the antimicrobial therapy, the evaluation of associated common bile duct stones, the identification of “high risk” patients, the surgical timing, the type of surgery, and the alternatives to surgery are discussed. Moreover the algorithm is proposed: as soon as diagnosis is made and after the evaluation of choledocholitiasis risk, laparoscopic cholecystectomy should be offered to all patients exception of those with high risk of morbidity or mortality. These Guidelines must be considered as an adjunctive tool for decision but they are not substitute of the clinical judgement for the individual patient.
Published: 2016

18. WSES Jerusalem guidelines for diagnosis and treatment of acute appendicitis

Author: Di Saverio, Salomone, Birindelli, Arianna, Kelly, Micheal D., Catena, Fausto, Weber, Dieter G., Sartelli, Massimo, Sugrue, Michael, De Moya, Mark, Augusto Gomes, Carlos, Bhangu, Aneel, Agresta, Ferdinando, Moore, Ernest E., Soreide, Kjetil, Griffiths, Ewen, De Castro, Steve, Kashuk, Jeffry, Kluger, Yoram, Leppaniemi, Ari, Ansaloni, Luca, Andersson, Manne, Coccolini, Federico, Coimbra, Raul, Gurusamy, Kurinchi S., Cesare Campanile, Fabio, Biffl, Walter, Chiara, Osvaldo, Moore, Fred, Peitzman, Andrew B., Fraga, Gustavo P., Costa, David, Maier, Ronald V., Rizoli, Sandro, Balogh, Zsolt J., Bendinelli, Cino, Cirocchi, Roberto, Tonini, Valeria, Piccinini, Alice, Tugnoli, Gregorio, Jovine, Elio, Persiani, Roberto, Biondi, Antonio, Scalea, Thomas, Stahel, Philip, Ivatury, Rao, Velmahos, George, Andersson, Roland, Di Saverio, Salomone, Birindelli, Arianna, Kelly, Micheal D., Catena, Fausto, Weber, Dieter G., Sartelli, Massimo, Sugrue, Michael, De Moya, Mark, Augusto Gomes, Carlos, Bhangu, Aneel, Agresta, Ferdinando, Moore, Ernest E., Soreide, Kjetil, Griffiths, Ewen, De Castro, Steve, Kashuk, Jeffry, Kluger, Yoram, Leppaniemi, Ari, Ansaloni, Luca, Andersson, Manne, Coccolini, Federico, Coimbra, Raul, Gurusamy, Kurinchi S., Cesare Campanile, Fabio, Biffl, Walter, Chiara, Osvaldo, Moore, Fred, Peitzman, Andrew B., Fraga, Gustavo P., Costa, David, Maier, Ronald V., Rizoli, Sandro, Balogh, Zsolt J., Bendinelli, Cino, Cirocchi, Roberto, Tonini, Valeria, Piccinini, Alice, Tugnoli, Gregorio, Jovine, Elio, Persiani, Roberto, Biondi, Antonio, Scalea, Thomas, Stahel, Philip, Ivatury, Rao, Velmahos, George, and Andersson, Roland
Abstract: Acute appendicitis (AA) is among the most common cause of acute abdominal pain. Diagnosis of AA is challenging; a variable combination of clinical signs and symptoms has been used together with laboratory findings in several scoring systems proposed for suggesting the probability of AA and the possible subsequent management pathway. The role of imaging in the diagnosis of AA is still debated, with variable use of US, CT and MRI in different settings worldwide. Up to date, comprehensive clinical guidelines for diagnosis and management of AA have never been issued. In July 2015, during the 3rd World Congress of the WSES, held in Jerusalem (Israel), a panel of experts including an Organizational Committee and Scientific Committee and Scientific Secretariat, participated to a Consensus Conference where eight panelists presented a number of statements developed for each of the eight main questions about diagnosis and management of AA. The statements were then voted, eventually modified and finally approved by the participants to The Consensus Conference and lately by the board of co-authors. The current paper is reporting the definitive Guidelines Statements on each of the following topics: 1) Diagnostic efficiency of clinical scoring systems, 2) Role of Imaging, 3) Non-operative treatment for uncomplicated appendicitis, 4) Timing of appendectomy and in-hospital delay, 5) Surgical treatment 6) Scoring systems for intra-operative grading of appendicitis and their clinical usefulness 7) Non-surgical treatment for complicated appendicitis: abscess or phlegmon 8) Pre-operative and post-operative antibiotics.
Published: 2016
Full Text: View/download PDF

19. WSES Jerusalem guidelines for diagnosis and treatment of acute appendicitis

Author: Di Saverio, Salomone, Birindelli, Arianna, Kelly, Micheal D., Catena, Fausto, Weber, Dieter G., Sartelli, Massimo, Sugrue, Michael, De Moya, Mark, Augusto Gomes, Carlos, Bhangu, Aneel, Agresta, Ferdinando, Moore, Ernest E., Soreide, Kjetil, Griffiths, Ewen, De Castro, Steve, Kashuk, Jeffry, Kluger, Yoram, Leppaniemi, Ari, Ansaloni, Luca, Andersson, Manne, Coccolini, Federico, Coimbra, Raul, Gurusamy, Kurinchi S., Cesare Campanile, Fabio, Biffl, Walter, Chiara, Osvaldo, Moore, Fred, Peitzman, Andrew B., Fraga, Gustavo P., Costa, David, Maier, Ronald V., Rizoli, Sandro, Balogh, Zsolt J., Bendinelli, Cino, Cirocchi, Roberto, Tonini, Valeria, Piccinini, Alice, Tugnoli, Gregorio, Jovine, Elio, Persiani, Roberto, Biondi, Antonio, Scalea, Thomas, Stahel, Philip, Ivatury, Rao, Velmahos, George, Andersson, Roland, Di Saverio, Salomone, Birindelli, Arianna, Kelly, Micheal D., Catena, Fausto, Weber, Dieter G., Sartelli, Massimo, Sugrue, Michael, De Moya, Mark, Augusto Gomes, Carlos, Bhangu, Aneel, Agresta, Ferdinando, Moore, Ernest E., Soreide, Kjetil, Griffiths, Ewen, De Castro, Steve, Kashuk, Jeffry, Kluger, Yoram, Leppaniemi, Ari, Ansaloni, Luca, Andersson, Manne, Coccolini, Federico, Coimbra, Raul, Gurusamy, Kurinchi S., Cesare Campanile, Fabio, Biffl, Walter, Chiara, Osvaldo, Moore, Fred, Peitzman, Andrew B., Fraga, Gustavo P., Costa, David, Maier, Ronald V., Rizoli, Sandro, Balogh, Zsolt J., Bendinelli, Cino, Cirocchi, Roberto, Tonini, Valeria, Piccinini, Alice, Tugnoli, Gregorio, Jovine, Elio, Persiani, Roberto, Biondi, Antonio, Scalea, Thomas, Stahel, Philip, Ivatury, Rao, Velmahos, George, and Andersson, Roland
Abstract: Acute appendicitis (AA) is among the most common cause of acute abdominal pain. Diagnosis of AA is challenging; a variable combination of clinical signs and symptoms has been used together with laboratory findings in several scoring systems proposed for suggesting the probability of AA and the possible subsequent management pathway. The role of imaging in the diagnosis of AA is still debated, with variable use of US, CT and MRI in different settings worldwide. Up to date, comprehensive clinical guidelines for diagnosis and management of AA have never been issued. In July 2015, during the 3rd World Congress of the WSES, held in Jerusalem (Israel), a panel of experts including an Organizational Committee and Scientific Committee and Scientific Secretariat, participated to a Consensus Conference where eight panelists presented a number of statements developed for each of the eight main questions about diagnosis and management of AA. The statements were then voted, eventually modified and finally approved by the participants to The Consensus Conference and lately by the board of co-authors. The current paper is reporting the definitive Guidelines Statements on each of the following topics: 1) Diagnostic efficiency of clinical scoring systems, 2) Role of Imaging, 3) Non-operative treatment for uncomplicated appendicitis, 4) Timing of appendectomy and in-hospital delay, 5) Surgical treatment 6) Scoring systems for intra-operative grading of appendicitis and their clinical usefulness 7) Non-surgical treatment for complicated appendicitis: abscess or phlegmon 8) Pre-operative and post-operative antibiotics.
Published: 2016
Full Text: View/download PDF

20. WSES Jerusalem guidelines for diagnosis and treatment of acute appendicitis

Author: Di Saverio, Salomone, Birindelli, Arianna, Kelly, Micheal D., Catena, Fausto, Weber, Dieter G., Sartelli, Massimo, Sugrue, Michael, De Moya, Mark, Augusto Gomes, Carlos, Bhangu, Aneel, Agresta, Ferdinando, Moore, Ernest E., Soreide, Kjetil, Griffiths, Ewen, De Castro, Steve, Kashuk, Jeffry, Kluger, Yoram, Leppaniemi, Ari, Ansaloni, Luca, Andersson, Manne, Coccolini, Federico, Coimbra, Raul, Gurusamy, Kurinchi S., Cesare Campanile, Fabio, Biffl, Walter, Chiara, Osvaldo, Moore, Fred, Peitzman, Andrew B., Fraga, Gustavo P., Costa, David, Maier, Ronald V., Rizoli, Sandro, Balogh, Zsolt J., Bendinelli, Cino, Cirocchi, Roberto, Tonini, Valeria, Piccinini, Alice, Tugnoli, Gregorio, Jovine, Elio, Persiani, Roberto, Biondi, Antonio, Scalea, Thomas, Stahel, Philip, Ivatury, Rao, Velmahos, George, Andersson, Roland, Di Saverio, Salomone, Birindelli, Arianna, Kelly, Micheal D., Catena, Fausto, Weber, Dieter G., Sartelli, Massimo, Sugrue, Michael, De Moya, Mark, Augusto Gomes, Carlos, Bhangu, Aneel, Agresta, Ferdinando, Moore, Ernest E., Soreide, Kjetil, Griffiths, Ewen, De Castro, Steve, Kashuk, Jeffry, Kluger, Yoram, Leppaniemi, Ari, Ansaloni, Luca, Andersson, Manne, Coccolini, Federico, Coimbra, Raul, Gurusamy, Kurinchi S., Cesare Campanile, Fabio, Biffl, Walter, Chiara, Osvaldo, Moore, Fred, Peitzman, Andrew B., Fraga, Gustavo P., Costa, David, Maier, Ronald V., Rizoli, Sandro, Balogh, Zsolt J., Bendinelli, Cino, Cirocchi, Roberto, Tonini, Valeria, Piccinini, Alice, Tugnoli, Gregorio, Jovine, Elio, Persiani, Roberto, Biondi, Antonio, Scalea, Thomas, Stahel, Philip, Ivatury, Rao, Velmahos, George, and Andersson, Roland
Abstract: Acute appendicitis (AA) is among the most common cause of acute abdominal pain. Diagnosis of AA is challenging; a variable combination of clinical signs and symptoms has been used together with laboratory findings in several scoring systems proposed for suggesting the probability of AA and the possible subsequent management pathway. The role of imaging in the diagnosis of AA is still debated, with variable use of US, CT and MRI in different settings worldwide. Up to date, comprehensive clinical guidelines for diagnosis and management of AA have never been issued. In July 2015, during the 3rd World Congress of the WSES, held in Jerusalem (Israel), a panel of experts including an Organizational Committee and Scientific Committee and Scientific Secretariat, participated to a Consensus Conference where eight panelists presented a number of statements developed for each of the eight main questions about diagnosis and management of AA. The statements were then voted, eventually modified and finally approved by the participants to The Consensus Conference and lately by the board of co-authors. The current paper is reporting the definitive Guidelines Statements on each of the following topics: 1) Diagnostic efficiency of clinical scoring systems, 2) Role of Imaging, 3) Non-operative treatment for uncomplicated appendicitis, 4) Timing of appendectomy and in-hospital delay, 5) Surgical treatment 6) Scoring systems for intra-operative grading of appendicitis and their clinical usefulness 7) Non-surgical treatment for complicated appendicitis: abscess or phlegmon 8) Pre-operative and post-operative antibiotics.
Published: 2016
Full Text: View/download PDF

21. WSES Jerusalem guidelines for diagnosis and treatment of acute appendicitis

Author: Di Saverio, Salomone, Birindelli, Arianna, Kelly, Micheal D., Catena, Fausto, Weber, Dieter G., Sartelli, Massimo, Sugrue, Michael, De Moya, Mark, Gomes, Carlos Augusto, Bhangu, Aneel, Agresta, Ferdinando, Moore, Ernest E., Soreide, Kjetil, Griffiths, Ewen, De Castro, Steve, Kashuk, Jeffry, Kluger, Yoram, Leppaniemi, Ari, Ansaloni, Luca, Andersson, Manne, Coccolini, Federico, Coimbra, Raul, Gurusamy, Kurinchi S., Campanile, Fabio Cesare, Biffl, Walter, Chiara, Osvaldo, Moore, Fred, Peitzman, Andrew B., Fraga, Gustavo P., Costa, David, Maier, Ronald V., Rizoli, Sandro, Balogh, Zsolt J, Bendinelli, Cino, Cirocchi, Roberto, Tonini, Valeria, Piccinini, Alice, Tugnoli, Gregorio, Jovine, Elio, Persiani, Roberto, Biondi, Antonio, Scalea, Thoma, Stahel, Philip, Ivatury, Rao, Velmahos, George, Andersson, Roland, Persiani, Roberto (ORCID:0000-0002-1537-5097), Di Saverio, Salomone, Birindelli, Arianna, Kelly, Micheal D., Catena, Fausto, Weber, Dieter G., Sartelli, Massimo, Sugrue, Michael, De Moya, Mark, Gomes, Carlos Augusto, Bhangu, Aneel, Agresta, Ferdinando, Moore, Ernest E., Soreide, Kjetil, Griffiths, Ewen, De Castro, Steve, Kashuk, Jeffry, Kluger, Yoram, Leppaniemi, Ari, Ansaloni, Luca, Andersson, Manne, Coccolini, Federico, Coimbra, Raul, Gurusamy, Kurinchi S., Campanile, Fabio Cesare, Biffl, Walter, Chiara, Osvaldo, Moore, Fred, Peitzman, Andrew B., Fraga, Gustavo P., Costa, David, Maier, Ronald V., Rizoli, Sandro, Balogh, Zsolt J, Bendinelli, Cino, Cirocchi, Roberto, Tonini, Valeria, Piccinini, Alice, Tugnoli, Gregorio, Jovine, Elio, Persiani, Roberto, Biondi, Antonio, Scalea, Thoma, Stahel, Philip, Ivatury, Rao, Velmahos, George, Andersson, Roland, and Persiani, Roberto (ORCID:0000-0002-1537-5097)
Abstract: Acute appendicitis (AA) is among the most common cause of acute abdominal pain. Diagnosis of AA is challenging; a variable combination of clinical signs and symptoms has been used together with laboratory findings in several scoring systems proposed for suggesting the probability of AA and the possible subsequent management pathway. The role of imaging in the diagnosis of AA is still debated, with variable use of US, CT and MRI in different settings worldwide. Up to date, comprehensive clinical guidelines for diagnosis and management of AA have never been issued. In July 2015, during the 3rd World Congress of the WSES, held in Jerusalem (Israel), a panel of experts including an Organizational Committee and Scientific Committee and Scientific Secretariat, participated to a Consensus Conference where eight panelists presented a number of statements developed for each of the eight main questions about diagnosis and management of AA. The statements were then voted, eventually modified and finally approved by the participants to The Consensus Conference and lately by the board of co-authors. The current paper is reporting the definitive Guidelines Statements on each of the following topics: 1) Diagnostic efficiency of clinical scoring systems, 2) Role of Imaging, 3) Non-operative treatment for uncomplicated appendicitis, 4) Timing of appendectomy and in-hospital delay, 5) Surgical treatment 6) Scoring systems for intra-operative grading of appendicitis and their clinical usefulness 7) Non-surgical treatment for complicated appendicitis: abscess or phlegmon 8) Pre-operative and post-operative antibiotics.
Published: 2016

22. Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Author: Sartelli, Massimo, Weber, Dieter G., Ruppé, Etienne, Bassetti, Matteo, Wright, Brian J., Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu Zidan, Fikri M., Coimbra, Raul, Moore, Ernest E., Moore, Frederick A., Maier, Ronald V., De Waele, Jan J., Kirkpatrick, Andrew W., Griffiths, Ewen A., Eckmann, Christian, Brink, Adrian J., Mazuski, John E., May, Addison K., Sawyer, Rob G., Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A., Vincent, Jean Loui, Watkins, Richard R., Lowman, Warren, Spellberg, Brad, Abbott, Iain J., Adesunkanmi, Abdulrashid Kayode, Al Dahir, Sara, Al Hasan, Majdi N., Agresta, Ferdinando, Althani, Asma A., Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussama, Bhangu, Aneel, Beltrán, Marcelo A., Bernhard, Michael, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Cherry Bukowiec, Jill R., Buyne, Otmar R., Cainzos, Miguel A., Cairns, Kelly A., Camacho Ortiz, Adrian, Chandy, Sujith J., Che Jusoh, Asri, Chichom Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, José J., Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P., Dorj, Gereltuya, Dogjani, Agron, Dupont, Hervé, Eachempati, Soumitra R., Enani, Mushira Abdulaziz, Egiev, Valery N., Elmangory, Mutasim M., Ferrada, Paula, Fitchett, Joseph R., Fraga, Gustavo P., Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R., Gomes, Carlos Augusto, Gomi, Harumi, Guzmán Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andrea, Heizmann, Wolfgang R., Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk Kyung, Kafka Ritsch, Reinhold, Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G., Kenig, Jakub, Kiguba, Ronald, Kim, Peter K., Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y. Y., Kong, Victory, Knox, Matthew C., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R., Labbate, Maurizio, Labricciosa, Francesco M., Laterre, Pierre Françoi, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y., Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E., Martin Loeches, Ignacio, Marwah, Sanjay, Massele, Amo, Mcfarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P., Nord, Carl Erik, Ofori Asenso, Richard, Omari, AbdelKarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Pereira Júnior, Gerson Alve, Piazza, Diego, Pupelis, Guntar, Rawson, Timothy Mile, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Bori, Sanchez Garcia, Miguel, Sato, Norio, Segovia Lohse, Helmut A., Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G., Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V., Timsit, Jean Francoi, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andra, Vohra, Ravinder S., Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo Ching, Zachariah, Sanoop K., Zahar, Jean Ralph, Zakrison, Tanya L., Corcione, Antonio, Melotti, Rita M., Viscoli, Claudio, Viale, Perluigi, Sganga, Gabriele (ORCID:0000-0001-5079-0395), Sartelli, Massimo, Weber, Dieter G., Ruppé, Etienne, Bassetti, Matteo, Wright, Brian J., Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu Zidan, Fikri M., Coimbra, Raul, Moore, Ernest E., Moore, Frederick A., Maier, Ronald V., De Waele, Jan J., Kirkpatrick, Andrew W., Griffiths, Ewen A., Eckmann, Christian, Brink, Adrian J., Mazuski, John E., May, Addison K., Sawyer, Rob G., Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A., Vincent, Jean Loui, Watkins, Richard R., Lowman, Warren, Spellberg, Brad, Abbott, Iain J., Adesunkanmi, Abdulrashid Kayode, Al Dahir, Sara, Al Hasan, Majdi N., Agresta, Ferdinando, Althani, Asma A., Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussama, Bhangu, Aneel, Beltrán, Marcelo A., Bernhard, Michael, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Cherry Bukowiec, Jill R., Buyne, Otmar R., Cainzos, Miguel A., Cairns, Kelly A., Camacho Ortiz, Adrian, Chandy, Sujith J., Che Jusoh, Asri, Chichom Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, José J., Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P., Dorj, Gereltuya, Dogjani, Agron, Dupont, Hervé, Eachempati, Soumitra R., Enani, Mushira Abdulaziz, Egiev, Valery N., Elmangory, Mutasim M., Ferrada, Paula, Fitchett, Joseph R., Fraga, Gustavo P., Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R., Gomes, Carlos Augusto, Gomi, Harumi, Guzmán Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andrea, Heizmann, Wolfgang R., Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk Kyung, Kafka Ritsch, Reinhold, Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G., Kenig, Jakub, Kiguba, Ronald, Kim, Peter K., Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y. Y., Kong, Victory, Knox, Matthew C., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R., Labbate, Maurizio, Labricciosa, Francesco M., Laterre, Pierre Françoi, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y., Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E., Martin Loeches, Ignacio, Marwah, Sanjay, Massele, Amo, Mcfarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P., Nord, Carl Erik, Ofori Asenso, Richard, Omari, AbdelKarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Pereira Júnior, Gerson Alve, Piazza, Diego, Pupelis, Guntar, Rawson, Timothy Mile, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Bori, Sanchez Garcia, Miguel, Sato, Norio, Segovia Lohse, Helmut A., Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G., Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V., Timsit, Jean Francoi, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andra, Vohra, Ravinder S., Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo Ching, Zachariah, Sanoop K., Zahar, Jean Ralph, Zakrison, Tanya L., Corcione, Antonio, Melotti, Rita M., Viscoli, Claudio, Viale, Perluigi, and Sganga, Gabriele (ORCID:0000-0001-5079-0395)
Abstract: Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.
Published: 2016

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1. ECLAPTE:Effective Closure of LAParoTomy in Emergency-2023 World Society of Emergency Surgery guidelines for the closure of laparotomy in emergency settings

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10. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA).

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13. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

14. WSES Jerusalem guidelines for diagnosis and treatment of acute appendicitis

15. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

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20. WSES Jerusalem guidelines for diagnosis and treatment of acute appendicitis

21. WSES Jerusalem guidelines for diagnosis and treatment of acute appendicitis

22. Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

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