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Your search keyword '"WIN55,212-2"' showing total 3 results
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3 results on '"WIN55,212-2"'

1. Cannabinoid agonist WIN55,212-2 induces apoptosis in cerebellar granule cells via activation of the CB1 receptor and downregulation of BCL-XL gene expression.

Author

Martire, Maria, Pozzoli, Giacomo, Tringali, Giuseppe, Vairano, Mauro, D'Amico, Monia, Navarra, Pierluigi, Martire, Maria (ORCID:0000-0003-1650-349X), Pozzoli, Giacomo (ORCID:0000-0003-0398-7026), Tringali, Giuseppe (ORCID:0000-0002-1030-9429), Navarra, Pierluigi (ORCID:0000-0002-4424-650X), Martire, Maria, Pozzoli, Giacomo, Tringali, Giuseppe, Vairano, Mauro, D'Amico, Monia, Navarra, Pierluigi, Martire, Maria (ORCID:0000-0003-1650-349X), Pozzoli, Giacomo (ORCID:0000-0003-0398-7026), Tringali, Giuseppe (ORCID:0000-0002-1030-9429), and Navarra, Pierluigi (ORCID:0000-0002-4424-650X)

Published
2006

3. Cannabinoids inhibit the release of [3H]glutamate from rodent hippocampal synaptosomes via a novel CB1 receptor-independent action

Author

Köfalvi, Attila, Vizi, E Sylvester, Ledent, Catherine, Sperlágh, Beáta, Köfalvi, Attila, Vizi, E Sylvester, Ledent, Catherine, and Sperlágh, Beáta

Abstract

In this study we investigated the effect of cannabinoids on [3H]glutamate release from hippocampal synaptosomes of rat and CB1-null mutant mouse. In the rat, cannabinoid receptor agonists, i.e. CP55,940 (EC50, 0.84 microm), WIN55,212-2 (EC50, 3.47 microm), ACEA (EC50, 17.8 microm), and R-(+)-methanandamide (EC50, 19.8 microm) concentration-dependently inhibited the 25-mm-K+ depolarization-evoked release of [3H]glutamate and, among them, WIN55,212-2 displayed the greatest efficacy. The CB1 receptor antagonists SR141716A (1-5 microm) and AM251 (1 microm) and the VR1 vanilloid receptor antagonist capsazepine (10 microm) did not antagonize the effect of the agonists. SR141716A by itself attenuated the evoked [3H]glutamate release. WIN55,212-2 inhibited the release of [3H]glutamate in CB1 -/- mice as well. These data demonstrate that the action of cannabinoids on glutamate release in the hippocampus is pharmacologically distinct and independent from the cloned CB1 receptor., SCOPUS: ar.j, FLWIN, info:eu-repo/semantics/published

Published
2003

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