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1. Targeting cancer stem cell OXPHOS with tailored ruthenium complexes as a new anti-cancer strategy

Author: Universidade de Santiago de Compostela. Departamento de Zooloxía, Xenética e Antropoloxía Física, Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares, Alcalá, Sonia, Villarino Palmaz, Lara, Ruiz-Cañas, Laura, Couceiro, José R., Martínez Calvo, Miguel, Palencia-Campos, Adrián, Navarro Vera, Diego, Cabezas Sainz, Pablo, Rodríguez-Arabaolaza, Iker, Cordero Barreal, Alfonso, Trilla-Fuertes, Lucía, Rubiolo Gaytán, Juan Andrés, Batres-Ramos, Sandra, Vallespinos Serrano, Mireia, González-Páramos, Cristina, Rodríguez Villar, Jéssica, Gámez-Pozo, Angelo, Fresno Vara, Juan Ángel, Fra Fernández, Sara, Benito Berlinches, Amparo, Moreno-Mata, Nicolás, Torres Redondo, Ana María, Carrato Mena, Alfredo, Hermann, Patrick C., Sánchez Piñón, Laura, Torrente Vilasánchez, Susana, Fernández-Moreno, Miguel Ángel, Mascareñas Cid, José Luis, Saínz, Bruno, Universidade de Santiago de Compostela. Departamento de Zooloxía, Xenética e Antropoloxía Física, Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares, Alcalá, Sonia, Villarino Palmaz, Lara, Ruiz-Cañas, Laura, Couceiro, José R., Martínez Calvo, Miguel, Palencia-Campos, Adrián, Navarro Vera, Diego, Cabezas Sainz, Pablo, Rodríguez-Arabaolaza, Iker, Cordero Barreal, Alfonso, Trilla-Fuertes, Lucía, Rubiolo Gaytán, Juan Andrés, Batres-Ramos, Sandra, Vallespinos Serrano, Mireia, González-Páramos, Cristina, Rodríguez Villar, Jéssica, Gámez-Pozo, Angelo, Fresno Vara, Juan Ángel, Fra Fernández, Sara, Benito Berlinches, Amparo, Moreno-Mata, Nicolás, Torres Redondo, Ana María, Carrato Mena, Alfredo, Hermann, Patrick C., Sánchez Piñón, Laura, Torrente Vilasánchez, Susana, Fernández-Moreno, Miguel Ángel, Mascareñas Cid, José Luis, and Saínz, Bruno
Abstract: Background Previous studies by our group have shown that oxidative phosphorylation (OXPHOS) is the main pathway by which pancreatic cancer stem cells (CSCs) meet their energetic requirements; therefore, OXPHOS represents an Achille’s heel of these highly tumorigenic cells. Unfortunately, therapies that target OXPHOS in CSCs are lacking. Methods The safety and anti-CSC activity of a ruthenium complex featuring bipyridine and terpyridine ligands and one coordination labile position (Ru1) were evaluated across primary pancreatic cancer cultures and in vivo, using 8 patient-derived xenografts (PDXs). RNAseq analysis followed by mitochondria-specific molecular assays were used to determine the mechanism of action. Results We show that Ru1 is capable of inhibiting CSC OXPHOS function in vitro, and more importantly, it presents excellent anti-cancer activity, with low toxicity, across a large panel of human pancreatic PDXs, as well as in colorectal cancer and osteosarcoma PDXs. Mechanistic studies suggest that this activity stems from Ru1 binding to the D-loop region of the mitochondrial DNA of CSCs, inhibiting OXPHOS complex-associated transcription, leading to reduced mitochondrial oxygen consumption, membrane potential, and ATP production, all of which are necessary for CSCs, which heavily depend on mitochondrial respiration. Conclusions Overall, the coordination complex Ru1 represents not only an exciting new anti-cancer agent, but also a molecular tool to dissect the role of OXPHOS in CSCs. Results indicating that the compound is safe, non-toxic and highly effective in vivo are extremely exciting, and have allowed us to uncover unprecedented mechanistic possibilities to fight different cancer types based on targeting CSC OXPHOS.
Published: 2024

2. Cross-basin and cross-taxa patterns of marine community tropicalization and deborealization in warming European seas

Author: Chust, Guillem, Villarino, Ernesto, McLean, Matthew, Mieszkowska, Nova, Benedetti-Cecchi, Lisandro, Bulleri, Fabio, Ravaglioli, Chiara, Borja, Angel, Muxika, Iñigo, Fernandes-Salvador, José A., Ibaibarriaga, Leire, Uriarte, Ainhize, Revilla, Marta, Villate, Fernando, Iriarte, Arantza, Uriarte, Ibon, Zervoudaki, Soultana, Carstensen, Jacob, Somerfield, Paul J., Queirós, Ana M., McEvoy, Andrea J., Auber, Arnaud, Hidalgo, Manuel, Coll, Marta, Garrabou, Joaquim, Gómez-Gras, Daniel, Linares, Cristina, Ramírez, Francisco, Margarit, Núria, Lepage, Mario, Dambrine, Chloé, Lobry, Jérémy, Peck, Myron A, de la Barra, Paula, van Leeuwen, Anieke, Rilov, Gil, Yeruham, Erez, Brind'Amour, Anik, Lindegren, Martin, Chust, Guillem, Villarino, Ernesto, McLean, Matthew, Mieszkowska, Nova, Benedetti-Cecchi, Lisandro, Bulleri, Fabio, Ravaglioli, Chiara, Borja, Angel, Muxika, Iñigo, Fernandes-Salvador, José A., Ibaibarriaga, Leire, Uriarte, Ainhize, Revilla, Marta, Villate, Fernando, Iriarte, Arantza, Uriarte, Ibon, Zervoudaki, Soultana, Carstensen, Jacob, Somerfield, Paul J., Queirós, Ana M., McEvoy, Andrea J., Auber, Arnaud, Hidalgo, Manuel, Coll, Marta, Garrabou, Joaquim, Gómez-Gras, Daniel, Linares, Cristina, Ramírez, Francisco, Margarit, Núria, Lepage, Mario, Dambrine, Chloé, Lobry, Jérémy, Peck, Myron A, de la Barra, Paula, van Leeuwen, Anieke, Rilov, Gil, Yeruham, Erez, Brind'Amour, Anik, and Lindegren, Martin
Abstract: Ocean warming and acidification, decreases in dissolved oxygen concentrations, and changes in primary production are causing an unprecedented global redistribution of marine life. The identification of underlying ecological processes underpinning marine species turnover, particularly the prevalence of increases of warm-water species or declines of cold-water species, has been recently debated in the context of ocean warming. Here, we track changes in the mean thermal affinity of marine communities across European seas by calculating the Community Temperature Index for 65 biodiversity time series collected over four decades and containing 1,817 species from different communities (zooplankton, coastal benthos, pelagic and demersal invertebrates and fish). We show that most communities and sites have clearly responded to ongoing ocean warming via abundance increases of warm-water species (tropicalization, 54%) and decreases of cold-water species (deborealization, 18%). Tropicalization dominated Atlantic sites compared to semi-enclosed basins such as the Mediterranean and Baltic Seas, probably due to physical barrier constraints to connectivity and species colonization. Semi-enclosed basins appeared to be particularly vulnerable to ocean warming, experiencing the fastest rates of warming and biodiversity loss through deborealization.
Published: 2024

3. Cross-basin and cross-taxa patterns of marine community tropicalization and deborealization in warming European seas

Author: Chust, Guillem, Villarino, Ernesto, Mclean, Matthew, Mieszkowska, Nova, Benedetti-cecchi, Lisandro, Bulleri, Fabio, Ravaglioli, Chiara, Borja, Angel, Muxika, Iñigo, Fernandes-salvador, José A., Ibaibarriaga, Leire, Uriarte, Ainhize, Revilla, Marta, Villate, Fernando, Iriarte, Arantza, Uriarte, Ibon, Zervoudaki, Soultana, Carstensen, Jacob, Somerfield, Paul J., Queirós, Ana M., Mcevoy, Andrea J., Auber, Arnaud, Hidalgo, Manuel, Coll, Marta, Garrabou, Joaquim, Gómez-gras, Daniel, Linares, Cristina, Ramírez, Francisco, Margarit, Núria, Lepage, Mario, Dambrine, Chloé, Lobry, Jérémy, Peck, Myron A., De La Barra, Paula, Van Leeuwen, Anieke, Rilov, Gil, Yeruham, Erez, Brind'Amour, Anik, Lindegren, Martin, Chust, Guillem, Villarino, Ernesto, Mclean, Matthew, Mieszkowska, Nova, Benedetti-cecchi, Lisandro, Bulleri, Fabio, Ravaglioli, Chiara, Borja, Angel, Muxika, Iñigo, Fernandes-salvador, José A., Ibaibarriaga, Leire, Uriarte, Ainhize, Revilla, Marta, Villate, Fernando, Iriarte, Arantza, Uriarte, Ibon, Zervoudaki, Soultana, Carstensen, Jacob, Somerfield, Paul J., Queirós, Ana M., Mcevoy, Andrea J., Auber, Arnaud, Hidalgo, Manuel, Coll, Marta, Garrabou, Joaquim, Gómez-gras, Daniel, Linares, Cristina, Ramírez, Francisco, Margarit, Núria, Lepage, Mario, Dambrine, Chloé, Lobry, Jérémy, Peck, Myron A., De La Barra, Paula, Van Leeuwen, Anieke, Rilov, Gil, Yeruham, Erez, Brind'Amour, Anik, and Lindegren, Martin
Abstract: Ocean warming and acidification, decreases in dissolved oxygen concentrations, and changes in primary production are causing an unprecedented global redistribution of marine life. The identification of underlying ecological processes underpinning marine species turnover, particularly the prevalence of increases of warm-water species or declines of cold-water species, has been recently debated in the context of ocean warming. Here, we track changes in the mean thermal affinity of marine communities across European seas by calculating the Community Temperature Index for 65 biodiversity time series collected over four decades and containing 1,817 species from different communities (zooplankton, coastal benthos, pelagic and demersal invertebrates and fish). We show that most communities and sites have clearly responded to ongoing ocean warming via abundance increases of warm-water species (tropicalization, 54%) and decreases of cold-water species (deborealization, 18%). Tropicalization dominated Atlantic sites compared to semi-enclosed basins such as the Mediterranean and Baltic Seas, probably due to physical barrier constraints to connectivity and species colonization. Semi-enclosed basins appeared to be particularly vulnerable to ocean warming, experiencing the fastest rates of warming and biodiversity loss through deborealization.
Published: 2024
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4. Metformin and Glucose Concentration as Limiting Factors in Retinal Pigment Epithelial Cell Viability and Proliferation

Author: Caja Rural de Asturias, Sociedad Asturiana de Diabetes, Endocrinología, Nutrición y Obesidad, Universidad de Barcelona, Villa-Fernández, Elsa, Garcia, Ana Victoria, Fernández-Fernández, Alejandra, García-Villarino, Miguel, Ares-Blanco, Jessica, Pujante Alarcón, Pedro, González-Vidal, Tomás, Fraga, Mario F., Menéndez Torre, Edelmiro, Delgado-Álvarez, Elías, Lambert, Carmen, Caja Rural de Asturias, Sociedad Asturiana de Diabetes, Endocrinología, Nutrición y Obesidad, Universidad de Barcelona, Villa-Fernández, Elsa, Garcia, Ana Victoria, Fernández-Fernández, Alejandra, García-Villarino, Miguel, Ares-Blanco, Jessica, Pujante Alarcón, Pedro, González-Vidal, Tomás, Fraga, Mario F., Menéndez Torre, Edelmiro, Delgado-Álvarez, Elías, and Lambert, Carmen
Abstract: Metformin is a well-established drug for the treatment of type 2 diabetes; however, the mechanism of action has not been well described and many aspects of how it truly acts are still unknown. Moreover, regarding in vitro experiments, the glycaemic status when metformin is used is generally not considered, which, added to the suprapharmacological drug concentrations that are commonly employed in research, has resulted in gaps of its mechanism of action. The aim of this study was to determine how glucose and metformin concentrations influence cell culture. Considering that diabetic retinopathy is one of the most common complications of diabetes, a retinal pigment epithelial cell line was selected, and cell viability and proliferation rates were measured at different glucose and metformin concentrations. As expected, glucose concentration by itself positively influenced cell proliferation rates. When the metformin was considered, results were conditioned, as well, by metformin concentration. This conditioning resulted in cell death when high concentrations of metformin were used under physiological concentrations of glucose, while this did not happen when clinically relevant concentrations of metformin were used independently of glucose status. Our study shows the importance of in vitro cell growth conditions when drug effects such as metformin’s are being analysed.
Published: 2024

5. Crohn´s disease is an independent risk factor for liver fibrosis in patients with inflammatory bowel disease and non-alcoholic fatty liver disease

Author: Diputación General de Aragón, Martínez-Domínguez, Samuel J., García-Mateo, Sandra, Gargallo-Puyuelo, Carla J., Gallego Llera, Beatriz, Refaie, Engy, Callau, Pilar, Mendi, Carolina, Baptista, Pedro M., Hernández Ainsa, María, Arroyo-Villarino, María Teresa, López de la Cruz, Julia, Martínez-García, Javier, Alfambra, Erika, Simón Marco, Miguel Ángel, Ampuero, Javier, Gomollón, Fernando, Diputación General de Aragón, Martínez-Domínguez, Samuel J., García-Mateo, Sandra, Gargallo-Puyuelo, Carla J., Gallego Llera, Beatriz, Refaie, Engy, Callau, Pilar, Mendi, Carolina, Baptista, Pedro M., Hernández Ainsa, María, Arroyo-Villarino, María Teresa, López de la Cruz, Julia, Martínez-García, Javier, Alfambra, Erika, Simón Marco, Miguel Ángel, Ampuero, Javier, and Gomollón, Fernando
Abstract: [Background and aims] Controversial data have been reported regarding the prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) in Inflammatory Bowel Disease (IBD) population and IBD-related risk factors. The aim of the study was to assess the prevalence and risk factors associated with NAFLD and liver fibrosis in IBD participants compared with non-IBD controls., [Methods] Cross-sectional, case-control study including 741 IBD cases and 170 non-IBD controls, matched by sex and age. All participants underwent liver ultrasound, transient elastography and laboratory tests. A logistic regression multivariable analysis was performed adjusting for classic metabolic risk factors and history of systemic steroid use., [Results] The prevalence of NAFLD and significant liver fibrosis was 45 % and 10 % in IBD group, and 40 % and 2.9 % in non-IBD group (p = 0.255 and 0.062, respectively). Longer IBD duration (aOR 1.02 95% CI (1.001–1.04)) and older age at IBD diagnosis (aOR 1.02 95 % CI (1.001–1.04)) were independent risk factors for NAFLD in IBD group. Crohn´s Disease was an independent risk factor for significant liver fibrosis in participants with IBD and NAFLD (aOR 3.97 95 % CI (1.78–8.96)). NAFLD occurred at lower BMI levels in IBD group with NAFLD compared to non-IBD group with NAFLD (aOR 0.92 95 % CI (0.87–0.98))., [Conclusions] Although we found no differences in the prevalence of NAFLD and liver fibrosis between IBD group and non-IBD group, our findings suggest that liver fibrosis progression should be closely monitored in patients with concomitant CD and NAFLD, more in particular in those with long standing active disease.
Published: 2024

6. Cambios espaciales y temporales en la composición de las capturas y su afinidad térmica: Un análisis por puerto y flota de la Costa Catalana

Author: Espasandín Soneira, Lucía, Ramírez Benítez, Francisco, Sbragaglia, Valerio, Ortega Cerdà, Miquel, Villarino, Ernesto, Chust, Guillem, Coll, Marta, Espasandín Soneira, Lucía, Ramírez Benítez, Francisco, Sbragaglia, Valerio, Ortega Cerdà, Miquel, Villarino, Ernesto, Chust, Guillem, and Coll, Marta
Abstract: Una de las principales consecuencias del cambio climático es el calentamiento de los océanos (Cheng et al., 2019; Pinsky et al., 2020M; Pörtner y Knust, 2007). Este calentamiento tiene consecuencias profundas para la vida marina y, en consecuencia para las actividades socioeconómicas que dependen de los recursos marinos [...]
Published: 2024

7. Cross-basin and cross-taxa patterns of marine community tropicalization and deborealization in warming European seas

Author: European Commission, Eusko Jaurlaritza, Agencia Estatal de Investigación (España), Chust, Guillem, Villarino, Ernesto, McLean, Matthew, Mieszkowska, Nova, Benedetti-Cecchi, Lisandro, Bulleri, Fabio, Ravaglioli, Chiara, Borja, Ángel, Muxika, Iñigo, Fernandes-Salvador, José A., Ibaibarriaga, Leire, Uriarte, Ainhize, Revilla, Marta, Villate, Fernando, Iriarte, Arantza, Uriarte, Ibon, Zervoudaki, Soultana, Carstensen, Jacob, Somerfield, Paul J., Queirós, Ana M., McEvoy, Andrea J., Auber, Arnaud, Hidalgo, Manuel, Coll, Marta, Garrabou, Joaquim, Gómez-Gras, D., Linares, Cristina, Ramírez Benítez, Francisco, Margarit, Núria, Lepage, Mario, Dambrine, Chloé, Lobry, Jérémy, Peck, Myron A., Barra, Paula de la, Leeuwen, Anieke van, Rilov, Gil, Yeruham, Erez, Brind’Amour, Anik, Lindegren, Martin, European Commission, Eusko Jaurlaritza, Agencia Estatal de Investigación (España), Chust, Guillem, Villarino, Ernesto, McLean, Matthew, Mieszkowska, Nova, Benedetti-Cecchi, Lisandro, Bulleri, Fabio, Ravaglioli, Chiara, Borja, Ángel, Muxika, Iñigo, Fernandes-Salvador, José A., Ibaibarriaga, Leire, Uriarte, Ainhize, Revilla, Marta, Villate, Fernando, Iriarte, Arantza, Uriarte, Ibon, Zervoudaki, Soultana, Carstensen, Jacob, Somerfield, Paul J., Queirós, Ana M., McEvoy, Andrea J., Auber, Arnaud, Hidalgo, Manuel, Coll, Marta, Garrabou, Joaquim, Gómez-Gras, D., Linares, Cristina, Ramírez Benítez, Francisco, Margarit, Núria, Lepage, Mario, Dambrine, Chloé, Lobry, Jérémy, Peck, Myron A., Barra, Paula de la, Leeuwen, Anieke van, Rilov, Gil, Yeruham, Erez, Brind’Amour, Anik, and Lindegren, Martin
Abstract: Ocean warming and acidification, decreases in dissolved oxygen concentrations, and changes in primary production are causing an unprecedented global redistribution of marine life. The identification of underlying ecological processes underpinning marine species turnover, particularly the prevalence of increases of warm-water species or declines of cold-water species, has been recently debated in the context of ocean warming. Here, we track changes in the mean thermal affinity of marine communities across European seas by calculating the Community Temperature Index for 65 biodiversity time series collected over four decades and containing 1,817 species from different communities (zooplankton, coastal benthos, pelagic and demersal invertebrates and fish). We show that most communities and sites have clearly responded to ongoing ocean warming via abundance increases of warm-water species (tropicalization, 54%) and decreases of cold-water species (deborealization, 18%). Tropicalization dominated Atlantic sites compared to semi-enclosed basins such as the Mediterranean and Baltic Seas, probably due to physical barrier constraints to connectivity and species colonization. Semi-enclosed basins appeared to be particularly vulnerable to ocean warming, experiencing the fastest rates of warming and biodiversity loss through deborealization
Published: 2024

8. HISTONE DEACETYLASE19 Controls Ovule Number Determination and Transmitting Tract Differentiation

Author: Manrique, Silvia; https://orcid.org/0000-0001-6241-4143, Cavalleri, Alex; https://orcid.org/0000-0003-4929-222X, Guazzotti, Andrea; https://orcid.org/0000-0003-4415-4004, Villarino, Gonzalo H; https://orcid.org/0000-0003-2832-6785, Simonini, Sara; https://orcid.org/0000-0002-3855-2447, Bombarely, Aureliano; https://orcid.org/0000-0001-6257-8914, Higashiyama, Tetsuya; https://orcid.org/0000-0002-7346-360X, Grossniklaus, Ueli; https://orcid.org/0000-0002-0522-8974, Mizzotti, Chiara; https://orcid.org/0000-0003-3644-2890, Pereira, Ana Marta; https://orcid.org/0000-0003-3665-7592, Coimbra, Silvia; https://orcid.org/0000-0001-9421-2538, Sankaranarayanan, Subramanian; https://orcid.org/0000-0002-0398-2113, Onelli, Elisabetta; https://orcid.org/0000-0003-3724-4116, Masiero, Simona; https://orcid.org/0000-0002-7563-7634, Franks, Robert G; https://orcid.org/0000-0002-3978-1030, Colombo, Lucia; https://orcid.org/0000-0001-8415-1399, Manrique, Silvia; https://orcid.org/0000-0001-6241-4143, Cavalleri, Alex; https://orcid.org/0000-0003-4929-222X, Guazzotti, Andrea; https://orcid.org/0000-0003-4415-4004, Villarino, Gonzalo H; https://orcid.org/0000-0003-2832-6785, Simonini, Sara; https://orcid.org/0000-0002-3855-2447, Bombarely, Aureliano; https://orcid.org/0000-0001-6257-8914, Higashiyama, Tetsuya; https://orcid.org/0000-0002-7346-360X, Grossniklaus, Ueli; https://orcid.org/0000-0002-0522-8974, Mizzotti, Chiara; https://orcid.org/0000-0003-3644-2890, Pereira, Ana Marta; https://orcid.org/0000-0003-3665-7592, Coimbra, Silvia; https://orcid.org/0000-0001-9421-2538, Sankaranarayanan, Subramanian; https://orcid.org/0000-0002-0398-2113, Onelli, Elisabetta; https://orcid.org/0000-0003-3724-4116, Masiero, Simona; https://orcid.org/0000-0002-7563-7634, Franks, Robert G; https://orcid.org/0000-0002-3978-1030, and Colombo, Lucia; https://orcid.org/0000-0001-8415-1399
Abstract: The gynoecium is critical for the reproduction of flowering plants as it contains the ovules and the tissues that foster pollen germination, growth, and guidance. These tissues, known as the reproductive tract (ReT), comprise the stigma, style, and transmitting tract (TT). The ReT and ovules originate from the carpel margin meristem (CMM) within the pistil. SHOOT MERISTEMLESS (STM) is a key transcription factor for meristem formation and maintenance. In all above-ground meristems, including the CMM, local STM downregulation is required for organ formation. However, how this downregulation is achieved in the CMM is unknown. Here, we have studied the role of HISTONE DEACETYLASE 19 (HDA19) in Arabidopsis (Arabidopsis thaliana) during ovule and ReT differentiation based on the observation that the hda19-3 mutant displays a reduced ovule number and fails to differentiate the TT properly. Fluorescence-activated cell sorting (FACS) coupled with RNA-sequencing (RNA-seq) revealed that in the CMM of hda19-3 mutants, genes promoting organ development are downregulated while meristematic markers, including STM, are upregulated. HDA19 was essential to downregulate STM in the CMM, thereby allowing ovule formation and TT differentiation. STM is ectopically expressed in hda19-3 at intermediate stages of pistil development, and its downregulation by RNA interference alleviated the hda19-3 phenotype. Chromatin immunoprecipitation assays indicated that STM is a direct target of HDA19 during pistil development and that the transcription factor SEEDSTICK is also required to regulate STM via histone acetylation. Thus, we identified factors required for the downregulation of STM in the CMM, which is necessary for organogenesis and tissue differentiation.
Published: 2024

9. Inequalities in digital welfare take-up: lessons from e-government in Spain

Author: taylor and francis, José Manuel Robles, Cristobal Torres-Albero, Guillermo Villarino, taylor and francis, José Manuel Robles, Cristobal Torres-Albero, and Guillermo Villarino
Abstract: E-government offers opportunities for improving the interactions between citizens, governmental and public institutions, private sector organizations, and public employees. Despite this, the take-up of e-government services has been vastly uneven in many societies with considerable digital divides existing. This study identifies the determinants of use of e-government in Spain through an analysis of the Survey on Equipment and Use of information and Communication Technologies in Households. A Path Analysis Model was used to identity the variables that explain why almost half of the Spanish population does not make use of E-government and how these variables are related. Two large groups of variables were found to be important: digital skills and trust in the Internet. Digital skills were affected by an individual citizens’ resources, such as their educational level and economic resources, as well as by age and gender. Meanwhile, their trust in the Internet was shaped by other attitudes and beliefs – mainly their concern about being targeted by advertising. These findings have important consequences for the design of policies to address digital inclusion across Europe and elsewhere, which need to focus on building citizen's trust., Ministerio de Ciencia, Innovación y Universidades, Depto. de Sociología Aplicada, Fac. de Ciencias Políticas y Sociología, TRUE, pub
Published: 2024

10. With sustainable use of local inputs, urban agriculture delivers community benefits beyond food.

Author: Gómez-Villarino, María Teresa, Gómez-Villarino, María Teresa, Briz, Teresa, Gómez-Villarino, María Teresa, Gómez-Villarino, María Teresa, and Briz, Teresa
Abstract: Urban agriculture is becoming increasingly important in developed countries, especially in terms of its economic and social benefits. If urban gardens are managed according to agroecological principles - involving the efficient and sustainable use of local resources and inputs - there are many environmental benefits to local communities. We studied urban gardens in Berkeley, California, and Madrid, Spain, to see how agroecology is practiced. Communities such as these that utilize good ecological practices in urban gardens obtain a wide range of valuable ecosystem services - the kinds of services provided by healthy ecosystems, including cultural services such as a place to socialize. These communities can serve as model urban agricultural centers which can contribute to the achievement of the United Nations Sustainable Development Goals, including good health, food security and sustainable cities.
Published: 2023

11. Comparative analysis of Penicillium genomes reveals the absence of a specific genetic basis for biocontrol in Penicillium rubens strain 212

Author: Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), European Commission, Requena, Elena [0000-0001-5028-8880], Alonso-Guirado, Lola [0000-0002-3493-718X], Veloso, Javier [0000-0002-7283-769X], Villarino, María [0000-0002-5635-8146], Espeso, Eduardo A. [0000-0002-5873-6059], Larena, Inmaculada [0000-0001-8424-8916], Melgarejo, Paloma [0000-0002-3698-8896], Requena, Elena, Alonso-Guirado, Lola, Veloso, Javier, Villarino, María, Melgarejo, Paloma, Espeso, Eduardo A., Larena, Inmaculada, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), European Commission, Requena, Elena [0000-0001-5028-8880], Alonso-Guirado, Lola [0000-0002-3493-718X], Veloso, Javier [0000-0002-7283-769X], Villarino, María [0000-0002-5635-8146], Espeso, Eduardo A. [0000-0002-5873-6059], Larena, Inmaculada [0000-0001-8424-8916], Melgarejo, Paloma [0000-0002-3698-8896], Requena, Elena, Alonso-Guirado, Lola, Veloso, Javier, Villarino, María, Melgarejo, Paloma, Espeso, Eduardo A., and Larena, Inmaculada
Abstract: Penicillium rubens strain 212 (PO212) is a filamentous fungus belonging to the division Ascomycete. PO212 acts as an effective biocontrol agent against several pathogens in a variety of horticultural crops including Fusarium oxysporum f.sp. lycopersici, causing vascular wilt disease in tomato plants. We assembled draft genomes of two P. rubens strains, the biocontrol agent PO212 and the soil isolate S27, which lacks biocontrol activity. We also performed comparative analyses of the genomic sequence of PO212 with that of the other P. rubens and P. chrysogenum strains. This is the first Penicillium strain with biocontrol activity whose genome has been sequenced and compared. PO212 genome size is 2,982 Mb, which is currently organized into 65 scaffolds and a total of 10,164 predicted Open Reading Frames (ORFs). Sequencing confirmed that PO212 belongs to P. rubens clade. The comparative analysis of the PO212 genome with the genomes of other P. rubens and Penicillium chrysogenum strains available in databases showed strong conservation among genomes, but a correlation was not found between these genomic data and the biocontrol phenotype displayed by PO212. Finally, the comparative analysis between PO212 and S27 genomes showed high sequence conservation and a low number of variations mainly located in ORF regions. These differences found in coding regions between PO212 and S27 genomes can explain neither the biocontrol activity of PO212 nor the absence of such activity in S27, opening a possible avenue toward transcriptomic and epigenetic studies that may shed light on this mechanism for fighting plant diseases caused by fungal pathogens. The genome sequences described in this study provide a useful novel resource for future research into the biology, ecology, and evolution of biological control agents.
Published: 2023

12. Microbial Biocontrol Agents for the Control of Postharvest Brown Rot on Stone Fruit

Author: De Cal Cortina, Antonieta [0000-0002-7725-7782], Guijarro Díaz-Otero, Belén [0000-0002-6488-6731], Villarino, María [0000-0002-5635-8146], Larena, Inmaculada [0000-0001-8424-8916], Melgarejo, Paloma [0000-0002-3698-8896], De Cal Cortina, Antonieta, Guijarro Díaz-Otero, Belén, Villarino, María, Larena, Inmaculada, Melgarejo, Paloma, De Cal Cortina, Antonieta [0000-0002-7725-7782], Guijarro Díaz-Otero, Belén [0000-0002-6488-6731], Villarino, María [0000-0002-5635-8146], Larena, Inmaculada [0000-0001-8424-8916], Melgarejo, Paloma [0000-0002-3698-8896], De Cal Cortina, Antonieta, Guijarro Díaz-Otero, Belén, Villarino, María, Larena, Inmaculada, and Melgarejo, Paloma
Abstract: Brown rot of stone fruit is one of the most important stone fruit diseases. The losses caused by this disease are mainly registered during the postharvest process, either in packing houses, or at the point of sale or at the consumer’s home. Microbial control has emerged as one of the most promising alternatives to chemical fungicides. Several microbial agents have been widely investigated for use on different postharvest pathogens. The efficacy of the microbial antagonist(s) such as Aureobasidium pullulans, Bacillus spp., Ceratocystis fimbriata, Debaryomyces hansenii, Epicoccum nigrum, Pantoea agglomerans, Penicillium frequentans, Pseudomonas spp., Streptomyces spp. and Wickerhamomyces anomalus are being used. Biocontrol products such as Amylo-X, BoniProtect, Julietta, Serenade Max and Serenade Aso have also been developed and registered. Although the results of this technology are encouraging, the formulation and application methods are key issues.
Published: 2022

13. A secondary metabolism pathway involved in the production of a putative toxin Is expressed at early stage of Monilinia laxa infection

Author: Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Villarino, María [0000-0002-5635-8146], Rodríguez-Pires, Silvia [0000-0001-7482-1715], Melgarejo, Paloma [0000-0002-3698-8896], Cal, Antonieta de [0000-0002-7725-7782], Espeso, Eduardo A. [0000-0002-5873-6059], Villarino, María, Rodríguez-Pires, Silvia, Requena, Elena, Melgarejo, Paloma, Cal, Antonieta de, Espeso, Eduardo A., Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Villarino, María [0000-0002-5635-8146], Rodríguez-Pires, Silvia [0000-0001-7482-1715], Melgarejo, Paloma [0000-0002-3698-8896], Cal, Antonieta de [0000-0002-7725-7782], Espeso, Eduardo A. [0000-0002-5873-6059], Villarino, María, Rodríguez-Pires, Silvia, Requena, Elena, Melgarejo, Paloma, Cal, Antonieta de, and Espeso, Eduardo A.
Abstract: The necrotrophic pathogenic fungus Monilinia laxa causes brown rot disease on stone fruit generating significant yield losses. So far, a limited number of pathogenesis-related virulence factors, such as cell wall degrading enzymes and potential phytotoxins, have been described in Monilinia spp. Using RNA-sequencing data from highly virulent M. laxa ML8L strain at early stages of the infection process (6, 14, 24, and 48 h post-inoculation, hpi) on nectarine and the Pathogen-Host-Interactions (PHI) database, we selected a number of genes for further study and ranked them according to their transcription levels. We identified a class of genes highly expressed at 6 hpi and that their expression decreased to almost undetectable levels at 14 to 48 hpi. Among these genes we found Monilinia__061040 encoding a non-ribosomal peptide synthase (NRPS). Monilinia__061040 together with other five co-regulated genes, forms a secondary metabolism cluster potentially involved in the production of epipolythiodioxopiperazine (ETP) toxin. Quantitative-PCR data confirmed previous RNA sequencing results from the virulent ML8L strain. Interestingly, in a less virulent M. laxa ML5L strain the expression levels of this pathway were reduced compared to the ML8L strain during nectarine infection. In vitro experiments showed that liquid medium containing peach extract mimicked the results observed using nectarines. In fact, upregulation of the NRPS coding gene was also observed in minimal medium suggesting the existence of a fruit-independent mechanism of regulation for this putative toxin biosynthetic pathway that is also downregulated in the less virulent strain. These results emphasize the role of this secondary metabolism pathway during the early stage of brown rot disease development and show alternative models to study the induction of virulence genes in this fungus.
Published: 2022

14. Evaluación del riesgo de trastornos de la conducta alimentaria en varones que practican deportes de equipo : comparación con una muestra de alto riesgo

Author: Villarino Marín, Antonio Luis, Bonfanti, Noelia, Baldó Vela, Daniel, Villarino Marín, Antonio Luis, Bonfanti, Noelia, and Baldó Vela, Daniel
Abstract: Los trastornos de la conducta alimentaria (TCAs) están caracterizados por la preocupación obsesiva sobre el peso y/o la forma corporal. Los jugadores de deportes de equipo son sistemáticamente excluidos de las poblaciones consideradas de alto riesgo de TCAs. Esta exención podría ser cuestionada por la evidencia de estudios previos que ponen de manifiesto una gran preocupación por la imagen corporal en estos jugadores, el desconocimiento de la prevalencia real de TCAs en el deporte y el elevado riesgo de infra diagnóstico alertado en hombres. Objetivos. Evaluar el riesgo de TCAs en varones que practican algún deporte de equipo federado: detectar sintomatología compatible, comparar los resultados con una población de alto riesgo y conocer las situaciones que implican una mayor vulnerabilidad. Metodología. Se realizó un estudio descriptivo-analítico con una muestra de 276 deportistas varones: 167 jugadores de deportes de equipo y 109 deportistas de modalidades de estética, resistencia y categorías de peso. Los datos fueron recogidos mediante un formulario online que incluyó una hoja de valoración general y cuatro herramientas validadas: Cuestionario de Hábitos Alimentarios del Deportista (CHAD), Test de Actitudes Alimentarias (EAT-40), Inventario de Desórdenes Alimentarios (EDI-2) y Cuestionario sobre la Forma Corporal (BSQ). Todos los sujetos firmaron un consentimiento informado antes de participar en el estudio. El análisis de datos se llevó a cabo mediante el software estadístico IBM SPSS versión 28.0.0. Resultados. El 20,36% de los jugadores de deportes de equipo presentó un cuadro clínico compatible con un diagnóstico de TCA. La Odds ratio no mostró diferencias significativas en la prevalencia de TCAs entre los dos grupos estudiados..., Eating disorders (EDs) are characterised by an exaggerated concern about body weight and shape. Male team sports players are usually excluded from the high-risk eating disorders groups. This exclusion could be challenged based on misinformation about the actual EDs prevalence within these sports, along with previous evidence showing significant body image concern among these players and the under-diagnosis risk in general men populations. Objectives. To determinate the prevalence of EDs in national adult male team sports players: to detect EDs symptoms, to compare the results with a high-risk sample and to assess the situations with greater risk. Methodology. An observational study was conducted with 276 male athletes: 167 male team sports players and 109 athletes of aesthetic, endurance, and weight categories sports. All subjects signed the informed consent before participating in the study. Data was collected via an online form including one sheet of general assessment and four validated questionnaires: the Eating Habits Questionnaire for Athletes (CHAD), the Eating Attitudes Test (EAT-40), the Inventory of Eating Disorders (EDI-2) and the Body Shape Questionnaire (BSQ). Data analysis was conducted with the software IBM SPSS 28.0.0. Results. 20.36% of male team sports players presented a clinical profile compatible with an ED diagnosis. Odds ratio test did not show significant differences in EDs prevalence between both studied groups...
Published: 2023

15. A New Edge Detection Method Based on Global Evaluation Using Supervised Classification Algorithms

Author: Flores Vidal, Pablo Arcadio, Villarino, Guillermo, Gómez, Daniel, Montero, Javier, Flores Vidal, Pablo Arcadio, Villarino, Guillermo, Gómez, Daniel, and Montero, Javier
Abstract: P. A. Flores-Vidal, G. Villarino, D. Gómez, and J. Montero, “A New Edge Detection Method Based on Global Evaluation Using Supervised Classification Algorithms,” vol. 12, no. 1, pp. 367–378, 2019, doi: https://doi.org/10.2991/ijcis.2019.125905653., Traditionally, the last step of edge detection algorithms, which is called scaling-evaluation, produces the final output classifying each pixel as edge or nonedge. This last step is usually done based on local evaluation methods. The local evaluation makes this classification based on measures obtained for every pixel. By contrast, in this work, we propose a global evaluation approach based on the idea of edge list to produce a solution that suits more with the human perception. In particular, we propose a new evaluation method that can be combined with any classical edge detection algorithm in an easy way to produce a novel edge detection algorithm. The new global evaluation method is divided in four steps: in first place we build the edge lists, that we have called edge segments. In second place we extract the characteristics associated to each segment: length, intensity, location, and so on. In the third step we learn the characteristics that make a segment good enough to become an edge. At the fourth step, we apply the classification task. In this work we have built the ground truth of edge list necessary for the supervised classification. Finally, we test the effectiveness of this algorithm against other classical algorithms based on local evaluation approach., Ministerio de Economía, Industria y Competitividad (MINECO), Comunidad de Madrid, Depto. de Estadística e Investigación Operativa, Fac. de Ciencias Matemáticas, TRUE, pub
Published: 2023

16. Creación de minivídeos sobre conceptos básicos de Derecho Civil: herramienta de aprendizaje e instrumento al servicio de la sociedad (street Law)

Author: Represa Polo, Mª Patricia, Álvarez Moreno, Mª Teresa, Amunátegui Rodríguez, Cristina de, Arrébola Blanco, Adrián, Sánchez Gómez, Amelia, Carrancho Herrero,. Mª Teresa, Ortega Domenech, Jorge, Anguita Villanueva, Luis, Zubero Quintanilla, Sara, Serrano Gómez, Eduardo, Alonso Sáinz, Carlota, Askarzadeh Trillo, Sara, González Gómez, Nuria, Barahona Larzón, Cassandra, Tudela Rosales, Natalia, Medina Ortega, Mª del Mar, Gómez Marcos, Lucía, Muñoz-Guerra Calvo, Diego, Villanueva Peiteado, Juan, Mejía Mediavilla, Carla, Vázquez Álvarez, Celia, Alexandru Brescan, Florin, González de Manuel, Irene, Aguilera Manzanera, Ana Mª, Llorente García, Andrea, Olga García Sánchez., Medina Ortega, María, Juberías Carrancho, Carmen, Núñez de Arenas Ramos, Diana, Villarino Tardío, Ángela Esther, Represa Polo, Mª Patricia, Álvarez Moreno, Mª Teresa, Amunátegui Rodríguez, Cristina de, Arrébola Blanco, Adrián, Sánchez Gómez, Amelia, Carrancho Herrero,. Mª Teresa, Ortega Domenech, Jorge, Anguita Villanueva, Luis, Zubero Quintanilla, Sara, Serrano Gómez, Eduardo, Alonso Sáinz, Carlota, Askarzadeh Trillo, Sara, González Gómez, Nuria, Barahona Larzón, Cassandra, Tudela Rosales, Natalia, Medina Ortega, Mª del Mar, Gómez Marcos, Lucía, Muñoz-Guerra Calvo, Diego, Villanueva Peiteado, Juan, Mejía Mediavilla, Carla, Vázquez Álvarez, Celia, Alexandru Brescan, Florin, González de Manuel, Irene, Aguilera Manzanera, Ana Mª, Llorente García, Andrea, Olga García Sánchez., Medina Ortega, María, Juberías Carrancho, Carmen, Núñez de Arenas Ramos, Diana, and Villarino Tardío, Ángela Esther
Published: 2023

17. Evaluación del riesgo de trastornos de la conducta alimentaria en varones que practican deportes de equipo : comparación con una muestra de alto riesgo

Author: Villarino Marín, Antonio Luis, Bonfanti, Noelia, Baldó Vela, Daniel, Villarino Marín, Antonio Luis, Bonfanti, Noelia, and Baldó Vela, Daniel
Abstract: Los trastornos de la conducta alimentaria (TCAs) están caracterizados por la preocupación obsesiva sobre el peso y/o la forma corporal. Los jugadores de deportes de equipo son sistemáticamente excluidos de las poblaciones consideradas de alto riesgo de TCAs. Esta exención podría ser cuestionada por la evidencia de estudios previos que ponen de manifiesto una gran preocupación por la imagen corporal en estos jugadores, el desconocimiento de la prevalencia real de TCAs en el deporte y el elevado riesgo de infra diagnóstico alertado en hombres. Objetivos. Evaluar el riesgo de TCAs en varones que practican algún deporte de equipo federado: detectar sintomatología compatible, comparar los resultados con una población de alto riesgo y conocer las situaciones que implican una mayor vulnerabilidad. Metodología. Se realizó un estudio descriptivo-analítico con una muestra de 276 deportistas varones: 167 jugadores de deportes de equipo y 109 deportistas de modalidades de estética, resistencia y categorías de peso. Los datos fueron recogidos mediante un formulario online que incluyó una hoja de valoración general y cuatro herramientas validadas: Cuestionario de Hábitos Alimentarios del Deportista (CHAD), Test de Actitudes Alimentarias (EAT-40), Inventario de Desórdenes Alimentarios (EDI-2) y Cuestionario sobre la Forma Corporal (BSQ). Todos los sujetos firmaron un consentimiento informado antes de participar en el estudio. El análisis de datos se llevó a cabo mediante el software estadístico IBM SPSS versión 28.0.0. Resultados. El 20,36% de los jugadores de deportes de equipo presentó un cuadro clínico compatible con un diagnóstico de TCA. La Odds ratio no mostró diferencias significativas en la prevalencia de TCAs entre los dos grupos estudiados..., Eating disorders (EDs) are characterised by an exaggerated concern about body weight and shape. Male team sports players are usually excluded from the high-risk eating disorders groups. This exclusion could be challenged based on misinformation about the actual EDs prevalence within these sports, along with previous evidence showing significant body image concern among these players and the under-diagnosis risk in general men populations. Objectives. To determinate the prevalence of EDs in national adult male team sports players: to detect EDs symptoms, to compare the results with a high-risk sample and to assess the situations with greater risk. Methodology. An observational study was conducted with 276 male athletes: 167 male team sports players and 109 athletes of aesthetic, endurance, and weight categories sports. All subjects signed the informed consent before participating in the study. Data was collected via an online form including one sheet of general assessment and four validated questionnaires: the Eating Habits Questionnaire for Athletes (CHAD), the Eating Attitudes Test (EAT-40), the Inventory of Eating Disorders (EDI-2) and the Body Shape Questionnaire (BSQ). Data analysis was conducted with the software IBM SPSS 28.0.0. Results. 20.36% of male team sports players presented a clinical profile compatible with an ED diagnosis. Odds ratio test did not show significant differences in EDs prevalence between both studied groups...
Published: 2023

18. Componentes del rendimiento en gimnasia rítmica individual

Author: Freire Maceiras, Rebeca, Fernández Villarino, María Ángeles, Sierra Palmeiro, Elena, Freire Maceiras, Rebeca, Fernández Villarino, María Ángeles, and Sierra Palmeiro, Elena
Abstract: Rhythmic Gymnastics is a sport in which competition performance is governed by criteria specified in the scoring code and depends on four components: body difficulty, apparatus difficulty, artistic execution and technical execution. The objective of the present study was to identify which of these components is the most significant in the performance in an individual exercise and if the level of the competition, the category (age of the gymnasts), or the apparatus with which the exercise is performed, modify their behavior. To carry out the study, the scores obtained in 2378 individual competition exercises were used, belonging to 3 different performance levels, and to four age categories. A descriptive analysis of the studied variables was carried out, the Pearson correlation to determine the association between the different variables, and a simple linear regression analysis to know the magnitude of the effects of the variables on the final grade. The results found indicate that the most important components in the composition of the exercises to obtain a higher score were, firstly, the apparatus difficulty score, then the body difficulty score, and in third place the technical execution score, being almost the note of artistic execution is irrelevant. Based on these results, training strategies should be directed towards exploring the gymnasts potential in apparatus difficulties, as well as optimizing the composition of the exercises based on this component., La Gimnasia Rítmica es un deporte en el que el rendimiento en la competición se rige por criterios especificados en el código de puntuación y depende de cuatro componentes: dificultad corporal, dificultad de aparato, ejecución artística y ejecución técnica. El objetivo del presente estudio fue identificar cuál de estos componentes es el más significativo en el rendimiento en un ejercicio individual y si el nivel de la competición, la categoría (edad de las gimnastas), o el aparato con el que se realiza el ejercicio, modifica su comportamiento. Para la realización del estudio se contó con las puntuaciones obtenidas en 2378 ejercicios de competición individual, pertenecientes a tres niveles de rendimiento distintos, y a cuatro categorías de edad. Se realizó un análisis descriptivo de las variables estudiadas, la correlación de Pearson para determinar la asociación entre las diferentes variables, y un análisis de regresión lineal simple para conocer la magnitud de los efectos de las variables sobre la nota final. Los resultados encontrados indican que los componentes más importantes en la composición de los ejercicios para obtener una puntuación más alta fueron, primer lugar la nota de dificultad de aparato, después la nota de dificultad corporal y en tercer lugar la nota de ejecución técnica, siendo casi irrelevante la nota de ejecución artística. Atendiendo a estos resultados, las estrategias de entrenamiento deberían dirigirse hacia la exploración del potencial de las gimnastas en las dificultades de aparato, así como optimizar la composición de los ejercicios en función de este componente.
Published: 2023

19. Druggable redox pathways against Mycobacterium abscessus in cystic fibrosis patient-derived airway organoids

Author: Leon-Icaza, Stephen Adonai, Bagayoko, Salimata, Vergé, Romain, Iakobachvili, Nino, Ferrand, Chloé, Aydogan, Talip, Bernard, Célia, Sanchez Dafun, Angelique, Murris-Espin, Marlène, Mazières, Julien, Bordignon, Pierre Jean, Mazères, Serge, Bernes-Lasserre, Pascale, Ramé, Victoria, Lagarde, Jean-Michel, Marcoux, Julien, Bousquet, Marie-Pierre, Chalut, Christian, Guilhot, Christophe, Clevers, Hans, Peters, Peter J, Molle, Virginie, Lugo-Villarino, Geanncarlo, Cam, Kaymeuang, Berry, Laurence, Meunier, Etienne, Cougoule, Céline, Leon-Icaza, Stephen Adonai, Bagayoko, Salimata, Vergé, Romain, Iakobachvili, Nino, Ferrand, Chloé, Aydogan, Talip, Bernard, Célia, Sanchez Dafun, Angelique, Murris-Espin, Marlène, Mazières, Julien, Bordignon, Pierre Jean, Mazères, Serge, Bernes-Lasserre, Pascale, Ramé, Victoria, Lagarde, Jean-Michel, Marcoux, Julien, Bousquet, Marie-Pierre, Chalut, Christian, Guilhot, Christophe, Clevers, Hans, Peters, Peter J, Molle, Virginie, Lugo-Villarino, Geanncarlo, Cam, Kaymeuang, Berry, Laurence, Meunier, Etienne, and Cougoule, Céline
Abstract: Mycobacterium abscessus (Mabs) drives life-shortening mortality in cystic fibrosis (CF) patients, primarily because of its resistance to chemotherapeutic agents. To date, our knowledge on the host and bacterial determinants driving Mabs pathology in CF patient lung remains rudimentary. Here, we used human airway organoids (AOs) microinjected with smooth (S) or rough (R-)Mabs to evaluate bacteria fitness, host responses to infection, and new treatment efficacy. We show that S Mabs formed biofilm, and R Mabs formed cord serpentines and displayed a higher virulence. While Mabs infection triggers enhanced oxidative stress, pharmacological activation of antioxidant pathways resulted in better control of Mabs growth and reduced virulence. Genetic and pharmacological inhibition of the CFTR is associated with better growth and higher virulence of S and R Mabs. Finally, pharmacological activation of antioxidant pathways inhibited Mabs growth, at least in part through the quinone oxidoreductase NQO1, and improved efficacy in combination with cefoxitin, a first line antibiotic. In conclusion, we have established AOs as a suitable human system to decipher mechanisms of CF-driven respiratory infection by Mabs and propose boosting of the NRF2-NQO1 axis as a potential host-directed strategy to improve Mabs infection control.
Published: 2023

20. Circulating miRNA expression in long-standing type 1 diabetes mellitus

Author: Fundación de la Sociedad Española de Diabetes, Universidad de Barcelona, Asociación Española Contra el Cáncer, Caja Rural de Asturias, Morales, Paula, Lambert, Carmen, Ares-Blanco, Jessica, Suárez-Gutiérrez, Lorena, Villa-Fernández, Elsa, Garcia, Ana Victoria, García-Villarino, Miguel, Tejedor, Juan Ramón, Fraga, Mario F., Menéndez Torre, Edelmiro, Pujante Alarcón, Pedro, Delgado-Álvarez, Elías, Fundación de la Sociedad Española de Diabetes, Universidad de Barcelona, Asociación Española Contra el Cáncer, Caja Rural de Asturias, Morales, Paula, Lambert, Carmen, Ares-Blanco, Jessica, Suárez-Gutiérrez, Lorena, Villa-Fernández, Elsa, Garcia, Ana Victoria, García-Villarino, Miguel, Tejedor, Juan Ramón, Fraga, Mario F., Menéndez Torre, Edelmiro, Pujante Alarcón, Pedro, and Delgado-Álvarez, Elías
Abstract: Type 1 diabetes is a chronic autoimmune disease which results in inefficient regulation of glucose homeostasis and can lead to different vascular comorbidities through life. In this study we aimed to analyse the circulating miRNA expression profile of patients with type 1 diabetes, and with no other associated pathology. For this, fasting plasma was obtained from 85 subjects. Next generation sequencing analysis was firstly performed to identify miRNAs that were differentially expressed between groups (20 patients vs. 10 controls). hsa-miR-1-3p, hsa-miR-200b-3p, hsa-miR-9-5p, and hsa-miR-1200 expression was also measured by Taqman RT-PCR to validate the observed changes (34 patients vs. 21 controls). Finally, through a bioinformatic approach, the main pathways affected by the target genes of these miRNAs were studied. Among the studied miRNAs, hsa-miR-1-3p expression was found significantly increased in patients with type 1 diabetes compared to controls, and positively correlated with glycated haemoglobin levels. Additionally, by using a bioinformatic approach, we could observe that changes in hsa-miR-1-3p directly affect genes involved in vascular development and cardiovascular pathologies. Our results suggest that, circulating hsa-miR-1-3p in plasma, together with glycaemic control, could be used as prognostic biomarkers in type 1 diabetes, helping to prevent the development of vascular complications in these patients.
Published: 2023

21. Physical activity in kindergarten, fundamental movement skills, and screen time in Spanish preschool children

Author: Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina, Carballo Fazanes, Aida, Díaz Pereira, María del Pino, Fernández Villarino, María A., Abelairas Gómez, Cristian, Rey Eiras, Ezequiel, Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina, Carballo Fazanes, Aida, Díaz Pereira, María del Pino, Fernández Villarino, María A., Abelairas Gómez, Cristian, and Rey Eiras, Ezequiel
Abstract: Schools have been postulated as ideal environments to encourage physical activity (PA). This study aimed to assess the relationship between PA in school hours, motor competence, and screen time in a sample of Spanish preschool children. Fifty-seven 4–5-year-old preschoolers (n = 32 girls) participated. The Garmin Vivofit wristband was used to measure the PA levels during school hours in a week. Sedentary behavior was estimated through screen-time hours reported by preschoolers' families and motor competence was assessed by the Athletic Skills Track. The anthropometry (weight/height) and demographic data were also collected. We found that motor competence was significantly associated with PA both in minutes and in steps. Therefore, increased motor competence was related to higher engagement in PA during school hours. No association was found between screen time and PA or proficiency of motor competence. No gender differences were found in any variable assessed. Based on the relationship between motor competence proficiency and the amount of PA in preschool children, our findings support the need for specific strategies to promote fundamental movement skills and increase PA practice from early childhood
Published: 2023

22. Strategies for transnational projection through international book fairs

Author: Universidade de Santiago de Compostela. Departamento de Filoloxía Galega, Villarino-Pardo, M. Carmen, Universidade de Santiago de Compostela. Departamento de Filoloxía Galega, and Villarino-Pardo, M. Carmen
Abstract: The following article aims to analyze the projection and representation of literary systems in some of the main international book fairs (IBF) at present, based on theoretical-methodological proposals from the Sociology of Literature and Culture (Bourdieu in ARSS 145, 3–8, 2002; Sapiro Translatio. Le marché de la traduction en France à l’heure de la mondialisation, CNRS Éditions, 2008; Even-Zohar, Polisistemas de Cultura. Laboratorio de investigación de la cultura, 2017). We begin with the hypothesis of considering IBFs as places for the acquisition of capital (literary, cultural, economic and symbolic) and for negotiating struggles for positions of greater or lesser centrality in the transnational literary field and in the world publishing market, and in terms of the image of countries, cultures, or cities. In those IBFs offering the position of Guest of Honor, this becomes a privileged opportunity—for governments, institutions and different actors involved in the book chain—for the international projection of the image of a country, culture, city or literary system. Different strategies for cultural and literary promotion in this worldwide scenario of symbolic goods will be discussed, with special attention to the case of Brazil (contrasted, partly, with that of Spain)
Published: 2023

23. Desarrollo del compromiso social en alumnos de ingeniería como motor de cambio para una sociedad más inclusiva: Proyecto COLABORA A LA PAR

Author: Perdigones Borderías, Alicia, Arteaga Bustamante, Clara de, García Fernández, José Luis, Ruiz Mazarrón, Fernando, Benavente León, Rosa María, Cañas Guerrero, Ignacio, Gómez Villarino, María Teresa, Palacios Orueta, Alicia, García Navarro, Justo, Hernández Díaz, Eduardo, Porras Prieto, Carlos Javier, Gil Sierra, Jacinto, García García, Ana Isabel, Álvarez Sánchez, José, Gilarranz Casado, Carlos, Gascó Guerrero, Gabriel, Méndez Lazaro, Ana María, Perdigones Borderías, Alicia, Arteaga Bustamante, Clara de, García Fernández, José Luis, Ruiz Mazarrón, Fernando, Benavente León, Rosa María, Cañas Guerrero, Ignacio, Gómez Villarino, María Teresa, Palacios Orueta, Alicia, García Navarro, Justo, Hernández Díaz, Eduardo, Porras Prieto, Carlos Javier, Gil Sierra, Jacinto, García García, Ana Isabel, Álvarez Sánchez, José, Gilarranz Casado, Carlos, Gascó Guerrero, Gabriel, and Méndez Lazaro, Ana María
Abstract: El proyecto de Aprendizaje-Servicio “Colabora A LA PAR” favorece el desarrollo de competencias sociales, entre otras, a través de la colaboración con la Fundación A LA PAR, siendo ésta el eje central de las actividades que en él se desarrollan. Está orientado a alumnos de los distintos Grados y Máster que se estudian en la ETSIAAB de la UPM, siendo de fácil implementación en otras titulaciones de ingeniería. A través de diversas actividades propuestas en diferentes asignaturas, (prácticas curriculares, trabajos fin de grado, actividades de diseño, debates, etc.), los alumnos toman conciencia del impacto que puede tener su profesión, orientada al diseño de instalaciones e infraestructuras, para las personas con discapacidad. El proyecto muestra el elevado compromiso del alumnado con este colectivo a través de su amplia participación en las actividades.
Published: 2023

24. International Human Rights, Artificial Intelligence, and the Challenge for the Pondering State: Time to Regulate?

Author: Bello y Villarino, J-M, Vijeyarasa, R, Bello y Villarino, J-M, and Vijeyarasa, R
Published: 2023

25. International Human Rights, Artificial Intelligence, and the Challenge for the Pondering State: Time to Regulate?

Author: Bello y Villarino, J-M, Vijeyarasa, R, Bello y Villarino, J-M, and Vijeyarasa, R
Published: 2023

26. Experiencias de Aprendizaje-Servicio en la UPM: 2021 y 2022

Author: Almendros García, Patricia, Otegui González, Silvia, Blanco Gutiérrez, Irene, Ferrer Lorenzo, Juan Ramón, Benito Hernández, Sonia, Lopéz Díaz, Carmen, García Marco, Sonia, Revuelta Peña, Fabio, Bernabéu Laren, Jorge, Hernández Lamas, Patricia, Gil Plana, Álvaro, Canalda Moreu, Fátima, Calderón Guerrero, Carlos, Margelí Espallargas, Javier, Echevarría Gómez-Escolar, Marta, García Herrero, Jesús, Gálvez Huerta, Miguel Ángel, Fernández Nieto, María Antonia, Parada Rodríguez, José Luis, Gallego Sánchez Torija, Jorge, González Redondo, Mercedes, García-Gutiérrez Mosteiro, Javier, Rabasa Díaz, Enrique, Gregorio Hurtado, Sonia de, Higueras García, Ester, Navacerrada Saturio, María de los Ángeles, García Morales, Soledad, Mohíno Sanz, María Inmaculada, García González, María Cristina, Mosquera Feijóo, Juan Carlos, Chang Recavarren, Gerardo, Chiyón Carrasco, Isabel, Quevedo Candela, Ana Valeria, García Alberti, Marcos, Cueto-Felgueroso Landeira, Luis, Suárez Guerra, Fernando, Perdigones Borderías, Alicia, Arteaga Bustamante, Clara de, García Fernández, José Luis, Ruiz Mazarrón, Fernando, Benavente León, Rosa María, Cañas Guerrero, Ignacio, Gómez Villarino, María Teresa, Palacios Orueta, Alicia, Ríos Carmenado, Ignacio de los, Nole, Priscila, Zuluaga Zuluaga, Claudia Liliana, Roncancio Burgos, Mayerly, Román López, María Emilia, Córdoba Hernández, Rafael, Sánchez-Guevara Sánchez, Carmen, Torrego, Daniel, Gayoso Heredia, Marta, Núñez Peiró, Miguel, Gómez Muñoz, Gloria María, Sánchez Aparicio, Luis Javier, Barbero Barrera, María del Mar, Santos Sopena, Óscar Oliver, Nares, Alejandro, Fresno, Laura del, Ablanque, Javier, Fernández, León, Zubelzu, Sergio, Sánchez, Raúl, Esteve, Paloma, Benito, Rosa María, Losada, Juan Carlos, Saa, Antonio, Gascó, Gabriel, Méndez, Ana María, Montoya, Mónica, Francisco, Marina de, Ruíz, Jesús, Seoanez, Samuel, Castilla, Sara, Fuente, Dámaris, Santiuste, Raquel, Polo, María Dolores, Viana, Juan Carlos, Serrano, Alberto, García, Raimundo, Burgas Fernández, Sergio, Gutiérrez, Aurora, Parra, Beatriz, Soto, Manuel, Domínguez, María Felisa, Martín, Cristina, López, Cristina, Alarcón, Juan Carlos, Alfonso Lidón, Nuria, Maroto, María José, Garde, Esther, Esteban, Elena, Veguillas, Lucía, Mora, Francisco, Prado Montalvo, María del, Villanueva, Olga, Villa, Elena, García, Justo, Gil, Jacinto, García, Ana Isabel, Álvarez, José, Gilarranz Casado, Carlos, Hernández, Eduardo, Neila González, Francisco Javier, Rodríguez Pérez, Manuel, González García, Isabel, Arranz Arranz, Beatriz, González Lezcano, Roberto, Pascual, Pablo, Porras Prieto, Carlos Javier, Ramírez Pacheco, Gema María, Almendros García, Patricia, Otegui González, Silvia, Blanco Gutiérrez, Irene, Ferrer Lorenzo, Juan Ramón, Benito Hernández, Sonia, Lopéz Díaz, Carmen, García Marco, Sonia, Revuelta Peña, Fabio, Bernabéu Laren, Jorge, Hernández Lamas, Patricia, Gil Plana, Álvaro, Canalda Moreu, Fátima, Calderón Guerrero, Carlos, Margelí Espallargas, Javier, Echevarría Gómez-Escolar, Marta, García Herrero, Jesús, Gálvez Huerta, Miguel Ángel, Fernández Nieto, María Antonia, Parada Rodríguez, José Luis, Gallego Sánchez Torija, Jorge, González Redondo, Mercedes, García-Gutiérrez Mosteiro, Javier, Rabasa Díaz, Enrique, Gregorio Hurtado, Sonia de, Higueras García, Ester, Navacerrada Saturio, María de los Ángeles, García Morales, Soledad, Mohíno Sanz, María Inmaculada, García González, María Cristina, Mosquera Feijóo, Juan Carlos, Chang Recavarren, Gerardo, Chiyón Carrasco, Isabel, Quevedo Candela, Ana Valeria, García Alberti, Marcos, Cueto-Felgueroso Landeira, Luis, Suárez Guerra, Fernando, Perdigones Borderías, Alicia, Arteaga Bustamante, Clara de, García Fernández, José Luis, Ruiz Mazarrón, Fernando, Benavente León, Rosa María, Cañas Guerrero, Ignacio, Gómez Villarino, María Teresa, Palacios Orueta, Alicia, Ríos Carmenado, Ignacio de los, Nole, Priscila, Zuluaga Zuluaga, Claudia Liliana, Roncancio Burgos, Mayerly, Román López, María Emilia, Córdoba Hernández, Rafael, Sánchez-Guevara Sánchez, Carmen, Torrego, Daniel, Gayoso Heredia, Marta, Núñez Peiró, Miguel, Gómez Muñoz, Gloria María, Sánchez Aparicio, Luis Javier, Barbero Barrera, María del Mar, Santos Sopena, Óscar Oliver, Nares, Alejandro, Fresno, Laura del, Ablanque, Javier, Fernández, León, Zubelzu, Sergio, Sánchez, Raúl, Esteve, Paloma, Benito, Rosa María, Losada, Juan Carlos, Saa, Antonio, Gascó, Gabriel, Méndez, Ana María, Montoya, Mónica, Francisco, Marina de, Ruíz, Jesús, Seoanez, Samuel, Castilla, Sara, Fuente, Dámaris, Santiuste, Raquel, Polo, María Dolores, Viana, Juan Carlos, Serrano, Alberto, García, Raimundo, Burgas Fernández, Sergio, Gutiérrez, Aurora, Parra, Beatriz, Soto, Manuel, Domínguez, María Felisa, Martín, Cristina, López, Cristina, Alarcón, Juan Carlos, Alfonso Lidón, Nuria, Maroto, María José, Garde, Esther, Esteban, Elena, Veguillas, Lucía, Mora, Francisco, Prado Montalvo, María del, Villanueva, Olga, Villa, Elena, García, Justo, Gil, Jacinto, García, Ana Isabel, Álvarez, José, Gilarranz Casado, Carlos, Hernández, Eduardo, Neila González, Francisco Javier, Rodríguez Pérez, Manuel, González García, Isabel, Arranz Arranz, Beatriz, González Lezcano, Roberto, Pascual, Pablo, Porras Prieto, Carlos Javier, and Ramírez Pacheco, Gema María
Abstract: La Oficina de Aprendizaje-Servicio (ApS) de la UPM, constituida en sesión del Consejo de Gobierno de diciembre de 2019 tiene, como misión fundamental, promover en el ámbito de las enseñanzas de esta universidad la metodología ApS. Con esta finalidad se vienen realizando convocatorias de proyectos de impacto social alineados con los ODS como un mecanismo más para la contribución a la Agenda 2030, y se colabora intensamente con las diversas oficinas constituidas con el mismo objetivo en otras universidades. Nuestra oficina pretende impulsar progresivamente la colaboración con entidades ajenas a la UPM, y atender demandas y necesidades sociales en las que nuestros estudiantes y profesores brinden sus conocimientos para la construcción de una mejor y más justa sociedad. Con este propósito, se han puesto en marcha numerosas iniciativas y colaboraciones con Ayuntamientos, Asociaciones, ONG, Fundaciones y centros de enseñanza, con el fin común de plantear mejoras y trabajar con entornos desfavorecidos, y colectivos vulnerables de nuestro entorno. Cabe destacar la muy positiva acogida que, progresivamente se está logrando, en lo relativo a la diseminación de estas iniciativas en el ámbito de la UPM, viéndose incrementada la participación e interés de nuestros docentes y estudiantes en los llamamientos que se realizan desde la oficina. Desde la constitución de la oficina, son ya más de 100 actividades desarrolladas con la participación de más de 500 profesores. Uno de los compromisos de la Oficina ApS de la UPM es dar visibilidad por su carácter meritorio a las experiencias realizadas por el profesorado y los estudiantes de nuestra universidad y, es por ello, que nos complace la presentación de esta primera edición del ebook, en el que se recogen algunas de las experiencias realizadas en nuestra universidad y que confiamos ampliar periódicamente con futuras ediciones. Nuestro más sincero agradecimiento a todos los profesores que habéis hecho posible esta primera publicación
Published: 2023

27. Sufficient conditions for the surjectivity of radical curve parametrizations

Author: Caravantes, Jorce, Sendra, J. Rafael, Sevilla, David, Villarino, Carlos, Caravantes, Jorce, Sendra, J. Rafael, Sevilla, David, and Villarino, Carlos
Abstract: In this paper, we introduce the notion of surjective radical parametrization and we prove sufficient conditions for a radical curve parametrization to be surjective., Comment: 18 pages, no figures
Published: 2023
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28. Boundary-safe PINNs extension: Application to non-linear parabolic PDEs in counterparty credit risk

Author: Pérez Villarino, Joel, Leitao, Álvaro, García Rodríguez, José Antonio, Pérez Villarino, Joel, Leitao, Álvaro, and García Rodríguez, José Antonio
Abstract: [Abstract]: The goal of this work is to develop a novel strategy for the treatment of the boundary conditions for multi-dimension nonlinear parabolic PDEs. The proposed methodology allows to get rid of the heuristic choice of the weights for the different addends that appear in the loss function related to the training process. It is based on defining the losses associated to the boundaries by means of the PDEs that arise from substituting the related conditions into the model equation itself. The approach is applied to challenging problems appearing in quantitative finance, namely, in counterparty credit risk management. Further, automatic differentiation is employed to obtain accurate approximation of the partial derivatives, the so called Greeks, that are very relevant quantities in the field.
Published: 2023

29. A trajetória de Caetano Veloso no campo cultural brasileiro da segunda metade do século XX

Author: Villarino Pardo, M. Carmen, Fernández Pérez-Sanjulián, Carme, Fernández Pérez-Sanjulián, Carme (Titora), Leira Lugrís, María Jesus, Villarino Pardo, M. Carmen, Fernández Pérez-Sanjulián, Carme, Fernández Pérez-Sanjulián, Carme (Titora), and Leira Lugrís, María Jesus
Abstract: [Resumo] Nesta tese estúdase a traxectoria de Caetano Veloso no espazo social brasileiro da segunda metade do século XX, tendo en conta a súa posición central no campo musical. A hipótese de partida foi a de que o compositor é tamén unha referencia para entender na actualidade tanto a cultura, como certas cuestións relativas ao espazo social brasileiro; máis do que un músico, é un dos axentes destacados do campo cultural no Brasil, un activista político e social, que vai ocupando diferentes posicións ao longo da súa traxectoria. Para demostralo, analízanse o espazo social, os diferentes campos culturais, a traxectoria de Veloso e a recepción crítica da súa produción, así como as dinámicas en que esta se insire. A partir da revisión de toda a súa produción (composicións, entrevistas, material audiovisual, etc.) son avaliadas as diferentes tomas de posición de Veloso e, tamén, as lecturas críticas e o impacto da súa traxectoria a nivel nacional e internacional. Finalmente, constátase que a consagración de Veloso no campo académico e cultural é produto do seu traballo intelectual, do seu elevado nivel de profesionalismo e da reflexión continua sobre o espazo social, a identidade do Brasil e os diversos campos culturais., [Resumen] En esta tesis se estudia la trayectoria de Caetano Veloso en el espacio social brasileño de la segunda mitad del siglo XX, teniendo en cuenta su posición central en el campo musical. La hipótesis de partida fue que el compositor también es una referencia para comprender en la actualidad tanto la cultura como ciertas cuestiones relacionadas con el espacio social brasileño; más que un músico, es uno de los agentes destacados del campo cultural en Brasil, un activista político y social, que va ocupando diferentes posiciones a lo largo de su trayectoria. Para demostrarlo se analizan el espacio social, los diferentes campos culturales, la trayectoria de Veloso y la recepción crítica de su producción, así como las dinámicas en las que se integra. A partir de la revisión de toda su producción (composiciones, entrevistas, material audiovisual, etc.), se evalúan las diferentes tomas de posiciones de Veloso, así como las lecturas críticas y el impacto de su trayectoria a nivel nacional e internacional. Finalmente, se constata que la consagración de Veloso en el campo académico y cultural es producto de su trabajo intelectual, su alto nivel de profesionalismo y la reflexión continua sobre el espacio social, la identidad de Brasil y los diversos campos culturales., [Abstract] This thesis studies the trajectory of Caetano Veloso in the Brazilian social space of the second half of the 20th century, taking into account his central position in the musical field. The starting hypothesis was that the composer is also a reference to understand both culture and certain issues related to the Brazilian social space; more than a musician, he is one of the outstanding agents of the cultural field in Brazil, a political and social activist, who has held different positions throughout his trajectory. To demonstrate this, the social space, the different cultural fields, Veloso's trajectory and the critical reception of his production are analyzed, as well as the dynamics in which he is inserted. From the review of all his production (compositions, interviews, audiovisual material, etc.), the different positions of Veloso are evaluated, as well as the critical readings and the impact of his trajectory at a national and international level. Finally, it is stated that Veloso's consecration in the academic and cultural field is the product of his intellectual work, his high level of professionalism and continuous reflection on the social space, the identity of Brazil and the various cultural fields.
Published: 2023

30. Proyecto parque urbano de 22 ha en un espacio degradado de Arganda del Rey (Madrid)

Author: Gómez Villarino, María Teresa, San José Aranda, Raquel, Gómez Villarino, María Teresa, and San José Aranda, Raquel
Abstract: El proyecto consiste en el diseño de un parque urbano en un terreno degradado de 22 hectáreas, en concreto sobre un antiguo olivar que ha perdido su función productora y se encuentra en evidente estado de deterioro. El ámbito está ubicado en el municipio de Arganda del Rey (Comunidad de Madrid), lindando en el este con el núcleo poblacional El Guijar y en el oeste con el Polígono industrial del mismo nombre. Las degradaciones más visibles aparecen en el lado oeste, debido a la acumulación de residuos y escombros. Sin embargo, el resto del ámbito se encuentra en buen estado, con abundante presencia de Olea europaea y una gran diversidad de fauna con gran valor ecológico como es el caso del conejo europeo. Arganda del Rey es un municipio en desarrollo de casi 60.000 habitantes, donde el número de parques o espacios verdes de ocio es reducido frente al número de habitantes, lo que origina disconformidad entre los ciudadanos. Por ello, el proyecto se ha orientado siguiendo unos principios para satisfacer la necesidades de la población, potenciar la conexión entre distintas áreas residenciales y proteger y preservar la fauna y flora existente. Para la realización del proyecto se ha realizado una caracterización ambiental y una evaluación por panel de expertos para buscar la alternativa de diseño más favorable para el ámbito. Tras la selección de la alternativa se han realizado las proyectado las actuaciones necesarias para el establecimiento del parque urbano. SUMMARY Arganda del Rey is a developing municipality of almost 60,000 inhabitants where the lack of parks and leisure spaces are causing discontent among inhabitants (according to our survey in 2022). Following the overwhelming demand from inhabitants, the focus of this project was to create leisure areas that are protective of native flora and fauna while satisfying the demand of neighboring communities. To design a solution, an expert panel carried out an environmental characterization and evaluation of the area
Published: 2023

31. Realització d'un receptor superheterodí per a les pràctiques d'emissors i receptors

Author: Villarino Villarino, Ramón, Girbau Sala, David, Torres Flores, Joan, Villarino Villarino, Ramón, Girbau Sala, David, and Torres Flores, Joan
Published: 2023

32. Druggable redox pathways against Mycobacterium abscessus in cystic fibrosis patient-derived airway organoids

Author: CMM, Cancer, Hubrecht Institute with UMC, Leon-Icaza, Stephen Adonai, Bagayoko, Salimata, Vergé, Romain, Iakobachvili, Nino, Ferrand, Chloé, Aydogan, Talip, Bernard, Célia, Dafun, Angelique Sanchez, Murris-Espin, Marlène, Mazières, Julien, Bordignon, Pierre Jean, Mazères, Serge, Bernes-Lasserre, Pascale, Ramé, Victoria, Lagarde, Jean Michel, Marcoux, Julien, Bousquet, Marie Pierre, Chalut, Christian, Guilhot, Christophe, Clevers, Hans, Peters, Peter J., Molle, Virginie, Lugo-Villarino, Geanncarlo, Cam, Kaymeuang, Berry, Laurence, Meunier, Etienne, Cougoule, Céline, CMM, Cancer, Hubrecht Institute with UMC, Leon-Icaza, Stephen Adonai, Bagayoko, Salimata, Vergé, Romain, Iakobachvili, Nino, Ferrand, Chloé, Aydogan, Talip, Bernard, Célia, Dafun, Angelique Sanchez, Murris-Espin, Marlène, Mazières, Julien, Bordignon, Pierre Jean, Mazères, Serge, Bernes-Lasserre, Pascale, Ramé, Victoria, Lagarde, Jean Michel, Marcoux, Julien, Bousquet, Marie Pierre, Chalut, Christian, Guilhot, Christophe, Clevers, Hans, Peters, Peter J., Molle, Virginie, Lugo-Villarino, Geanncarlo, Cam, Kaymeuang, Berry, Laurence, Meunier, Etienne, and Cougoule, Céline
Published: 2023

33. Unravelling the cellular response to the SARS-COV-2 vaccine in inflammatory bowel disease patients on biologic drugs

Author: Diputación General de Aragón, Gobierno de Aragón, European Commission, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Ciencia e Innovación (España), Fundación Inocente Inocente, Asociación Española Contra el Cáncer, Aspanoa, Asociación Carrera de la Mujer Ciudad de Monzón, Martínez-Domínguez, Samuel J., García-Mateo, Sandrfa, Sainz-Arnal, Pilar, Martínez-García, Javier, Gallego-Llera, Beatriz, Lozano-Limones, María Jesús, Hidalgo, Sandra, Gargallo-Puyuelo, Carla J., Latre-Santos, Marta, Lourdes Nocito-Colon, Maria Mercedes, Martínez-Lostao, Luis, Refaie, Engy, Arroyo-Villarino, Maria Teresa, Rio-Nechaevsky, Marcela del, Ramírez-Labrada, Ariel, Pardo, Julián, Gomollón, Fernando, Baptista, Pedro M., Diputación General de Aragón, Gobierno de Aragón, European Commission, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Ciencia e Innovación (España), Fundación Inocente Inocente, Asociación Española Contra el Cáncer, Aspanoa, Asociación Carrera de la Mujer Ciudad de Monzón, Martínez-Domínguez, Samuel J., García-Mateo, Sandrfa, Sainz-Arnal, Pilar, Martínez-García, Javier, Gallego-Llera, Beatriz, Lozano-Limones, María Jesús, Hidalgo, Sandra, Gargallo-Puyuelo, Carla J., Latre-Santos, Marta, Lourdes Nocito-Colon, Maria Mercedes, Martínez-Lostao, Luis, Refaie, Engy, Arroyo-Villarino, Maria Teresa, Rio-Nechaevsky, Marcela del, Ramírez-Labrada, Ariel, Pardo, Julián, Gomollón, Fernando, and Baptista, Pedro M.
Abstract: Suboptimal vaccine response is a significant concern in patients with Inflammatory Bowel Disease (IBD) receiving biologic drugs. This single-center observational study involved 754 patients with IBD. In Phase I (October 2020-April 2021), 754 IBD participants who had not previously received the SARS-CoV-2 vaccine, underwent blood extraction to assess the seroprevalence of SARS-CoV-2 infection and IBD-related factors. Phase II (May 2021-October 2021) included a subgroup of 52 IBD participants with confirmed previous SARS-CoV-2 infection, who were studied for humoral and cellular response to the SARS-CoV-2 vaccine. In Phase I, treatment with anti-TNF was associated with lower rates of seroconversion (aOR 0.25 95% CI [0.10–0.61]). In Phase II, a significant increase in post-vaccination IgG levels was observed regardless of biologic treatment. However, patients treated with anti-TNF exhibited significantly lower IgG levels compared to those without IBD therapy (5.32 ± 2.47 vs. 7.99 ± 2.59 U/ml, p = 0.042). Following vaccination, a lymphocyte, monocyte, and NK cell activation pattern was observed, with no significant differences between patients receiving biologic drugs and those without IBD treatment. Despite lower seroprevalence and humoral response to the SARS-CoV-2 vaccine in patients treated with anti-TNF, the cellular response to the vaccine did not differ significantly from that patients without IBD therapy.
Published: 2023

34. Condiciones del Trabajo. Ciberataques como causa de ERTES por fuerza mayor: su acreditación y carácter inevitable

Author: Fernández Villarino, Roberto and Fernández Villarino, Roberto
Abstract: Sentencia de la Audiencia Nacional de núm. 67/2023 de 26 de mayo de 2023 ECLI:ES:AN:2023:2645
Published: 2023

35. Acceptable risks in Europe's proposed AI Act: Reasonableness and other principles for deciding how much risk management is enough

Author: Fraser, Henry, Villarino, Jose-Miguel Bello y, Fraser, Henry, and Villarino, Jose-Miguel Bello y
Abstract: This paper critically evaluates the European Commission's proposed AI Act's approach to risk management and risk acceptability for high-risk AI systems that pose risks to fundamental rights and safety. The Act aims to promote "trustworthy" AI with a proportionate regulatory burden. Its provisions on risk acceptability require residual risks from high-risk systems to be reduced or eliminated "as far as possible", having regard to the "state of the art". This criterion, especially if interpreted narrowly, is unworkable and promotes neither proportionate regulatory burden, nor trustworthiness. By contrast the Parliament's most recent draft amendments to the risk management provisions introduce "reasonableness", cost-benefit analysis, and are more transparent about the value-laden and contextual nature of risk acceptability judgements. This paper argues that the Parliament's approach is more workable, and better balances the goals of proportionality and trustworthiness. It explains what reasonableness in risk acceptability judgments would entail, drawing on principles from negligence law and European medical devices regulation. And it contends that the approach to risk acceptability judgments need a firm foundation of civic legitimacy: including detailed guidance or involvement from regulators, and meaningful input from affected stakeholders.
Published: 2023

36. Recent Advances in Batteryless NFC Sensors for Chemical Sensing and Biosensing

Author: Universitat Rovira i Virgili, Lazaro, A; Villarino, R; Lazaro, M; Canellas, N; Prieto-Simon, B; Girbau, D, Universitat Rovira i Virgili, and Lazaro, A; Villarino, R; Lazaro, M; Canellas, N; Prieto-Simon, B; Girbau, D
Abstract: This article reviews the recent advances in the field of batteryless near-field communication (NFC) sensors for chemical sensing and biosensing. The commercial availability of low-cost commercial NFC integrated circuits (ICs) and their massive integration in smartphones, used as readers and cloud interfaces, have aroused great interest in new batteryless NFC sensors. The fact that coil antennas are not importantly affected by the body compared with other wireless sensors based on far-field communications makes this technology suitable for future wearable point-of-care testing (PoCT) devices. This review first compares energy harvesting based on NFC to other energy-harvesting technologies. Next, some practical recommendations for designing and tuning NFC-based tags are described. Power transfer is key because in most cases, the energy harvested has to be stable for several seconds and not contaminated by undesired signals. For this reason, the effect of the dimensions of the coils and the conductivity on the wireless power transfer is thoroughly discussed. In the last part of the review, the state of the art in NFC-based chemical and biosensors is presented. NFC-based tags (or sensor tags) are mainly based on commercial or custom NFC ICs, which are used to harvest the energy from the RF field generated by the smartphone to power the electronics. Low-consumption colorimeters and potentiostats can be integrated into these NFC tags, opening the door to the integration of chemical sensors and biosensors, which can be harvested and read from a smartphone. The smartphone is also used to upload the acquired information to the cloud to facilitate the internet of medical things (IoMT) paradigm. Finally, several chipless sensors recently proposed in the literature as a low-cost al
Published: 2023

37. Smart Spread Spectrum Modulated Tags for Detection of Vulnerable Road Users with Automotive Radar

Author: Universitat Rovira i Virgili, Lazaro, A; Lazaro, M; Villarino, R; Girbau, D, Universitat Rovira i Virgili, and Lazaro, A; Lazaro, M; Villarino, R; Girbau, D
Abstract: In recent years, there has been a significant increase in the number of collisions between vehicles and vulnerable road users such as pedestrians, cyclists, road workers and more recently scooter riders, especially in urban streets. This work studies the feasibility of enhancing the detection of these users by means of CW radars because they have a low radar cross section. Since the speed of these users is usually low, they can be confused with clutter due to the presence of large objects. To this end, this paper proposes, for the first time, a method based on a spread spectrum radio communication between vulnerable road users and the automotive radar consisting of modulating a backscatter tag, placed on the user. In addition, it is compatible with low-cost radars that use different waveforms such as CW, FSK or FMCW, and hardware modifications are not required. The prototype that has been developed is based on a commercial monolithic microwave integrated circuit (MMIC) amplifier connected between two antennas, which is modulated by switching its bias. Experimental results with a scooter, under static and moving conditions, using a low-power Doppler radar at a 24 GHz band compatible with blind spot radars, are provided.
Published: 2023

38. Introduction, Transmission Dynamics, and Fate of Early Severe Acute Respiratory Syndrome Coronavirus 2 Lineages in Santa Clara County, California.

Author: Villarino, Elsa, Villarino, Elsa, Deng, Xianding, Kemper, Carol A, Jorden, Michelle A, Bonin, Brandon, Rudman, Sarah L, Han, George S, Yu, Guixia, Wang, Candace, Federman, Scot, Bushnell, Brian, CZB COVIDTracker Consortium, Wadford, Debra A, Lin, Wen, Tao, Ying, Paden, Clinton R, Bhatnagar, Julu, MacCannell, Tara, Tong, Suxiang, Batson, Joshua, Chiu, Charles Y, Villarino, Elsa, Villarino, Elsa, Deng, Xianding, Kemper, Carol A, Jorden, Michelle A, Bonin, Brandon, Rudman, Sarah L, Han, George S, Yu, Guixia, Wang, Candace, Federman, Scot, Bushnell, Brian, CZB COVIDTracker Consortium, Wadford, Debra A, Lin, Wen, Tao, Ying, Paden, Clinton R, Bhatnagar, Julu, MacCannell, Tara, Tong, Suxiang, Batson, Joshua, and Chiu, Charles Y
Abstract: We combined viral genome sequencing with contact tracing to investigate introduction and evolution of severe acute respiratory syndrome coronavirus 2 lineages in Santa Clara County, California, from 27 January to 21 March 2020. From 558 persons with coronavirus disease 2019, 101 genomes from 143 available clinical samples comprised 17 lineages, including SCC1 (n = 41), WA1 (n = 9; including the first 2 reported deaths in the United States, with postmortem diagnosis), D614G (n = 4), ancestral Wuhan Hu-1 (n = 21), and 13 others (n = 26). Public health intervention may have curtailed the persistence of lineages that appeared transiently during February and March. By August, only D614G lineages introduced after 21 March were circulating in Santa Clara County.
Published: 2021

39. Introduction, Transmission Dynamics, and Fate of Early Severe Acute Respiratory Syndrome Coronavirus 2 Lineages in Santa Clara County, California.

Author: Villarino, Elsa, Villarino, Elsa, Deng, Xianding, Kemper, Carol A, Jorden, Michelle A, Bonin, Brandon, Rudman, Sarah L, Han, George S, Yu, Guixia, Wang, Candace, Federman, Scot, Bushnell, Brian, CZB COVIDTracker Consortium, Wadford, Debra A, Lin, Wen, Tao, Ying, Paden, Clinton R, Bhatnagar, Julu, MacCannell, Tara, Tong, Suxiang, Batson, Joshua, Chiu, Charles Y, Villarino, Elsa, Villarino, Elsa, Deng, Xianding, Kemper, Carol A, Jorden, Michelle A, Bonin, Brandon, Rudman, Sarah L, Han, George S, Yu, Guixia, Wang, Candace, Federman, Scot, Bushnell, Brian, CZB COVIDTracker Consortium, Wadford, Debra A, Lin, Wen, Tao, Ying, Paden, Clinton R, Bhatnagar, Julu, MacCannell, Tara, Tong, Suxiang, Batson, Joshua, and Chiu, Charles Y
Abstract: We combined viral genome sequencing with contact tracing to investigate introduction and evolution of severe acute respiratory syndrome coronavirus 2 lineages in Santa Clara County, California, from 27 January to 21 March 2020. From 558 persons with coronavirus disease 2019, 101 genomes from 143 available clinical samples comprised 17 lineages, including SCC1 (n = 41), WA1 (n = 9; including the first 2 reported deaths in the United States, with postmortem diagnosis), D614G (n = 4), ancestral Wuhan Hu-1 (n = 21), and 13 others (n = 26). Public health intervention may have curtailed the persistence of lineages that appeared transiently during February and March. By August, only D614G lineages introduced after 21 March were circulating in Santa Clara County.
Published: 2021

40. Development of a multiplex PCR for the identification of Fusarium solani and F. oxysporum in a single step

Author: European Commission, Ministerio de Economía y Competitividad (España), Villarino, María [0000-0002-5635-8146], De Cal Cortina, Antonieta [0000-0002-7725-7782], Melgarejo, Paloma [0000-0002-3698-8896], Larena, Inmaculada [0000-0001-8424-8916], Villarino, María, De Cal Cortina, Antonieta, Melgarejo, Paloma, Larena, Inmaculada, European Commission, Ministerio de Economía y Competitividad (España), Villarino, María [0000-0002-5635-8146], De Cal Cortina, Antonieta [0000-0002-7725-7782], Melgarejo, Paloma [0000-0002-3698-8896], Larena, Inmaculada [0000-0001-8424-8916], Villarino, María, De Cal Cortina, Antonieta, Melgarejo, Paloma, and Larena, Inmaculada
Abstract: Fusarium solani and F. oxysporum are plant pathogenic fungi that cause root rot and wilt, respectively, in many economically important crops. Identification of both species by morphological characteristics is complex and time-consuming, especially when a crop is host to several species, as in the case of strawberry and other many crops. The objective of this research was to develop a molecular method for the precise and sensitive identification of Fusarium solani and F. oxysporum by multiplex PCR. Specific PCR conditions were developed for the amplification of about 170-bp PCR product from the internal transcribed spacer of F. oxysporum and a PCR product of about 650 bp from the elongation factor 1-alpha gene of F. solani. The specificity of the multiplex PCR was tested using gDNA extracted from 232 strains of F. solani and F. oxysporum, 12 strains of other Fusarium spp. and 14 strains of other genera. The sensitivity of each primer set was tested individually and simultaneously with one strain of F. oxysporum and F. solani. This protocol was then used to identify both species in natural isolates from diseased plant and soil samples from strawberry nursery. Each primer set was validated using genomic DNA from non-sterile and sterile soils artificially inoculated with both species. Under these conditions, both Fusarium species were detected and distinguished over a range of concentrations (1 × 107 to 1 × 102 conidia g−1 soil) by successful amplification of corresponding PCR products for each species. This multiplex PCR technique is a fast tool to identify natural isolates of both species, F. solani and F. oxysporum, in a single PCR reaction.
Published: 2021

41. Epidemiological Studies of Brown Rot in Spanish Cherry Orchards in the Jerte Valley

Author: Ministerio de Ciencia, Innovación y Universidades (España), European Agricultural Fund for Rural Development, Ministerio de Agricultura, Pesca y Alimentación (España), Agricultural European Innovation Partnership, Larena, Inmaculada [0000-0001-8424-8916], Villarino, María [0000-0002-5635-8146], Melgarejo, Paloma [0000-0002-3698-8896], De Cal Cortina, Antonieta [0000-0002-7725-7782], Larena, Inmaculada, Villarino, María, Melgarejo, Paloma, De Cal Cortina, Antonieta, Ministerio de Ciencia, Innovación y Universidades (España), European Agricultural Fund for Rural Development, Ministerio de Agricultura, Pesca y Alimentación (España), Agricultural European Innovation Partnership, Larena, Inmaculada [0000-0001-8424-8916], Villarino, María [0000-0002-5635-8146], Melgarejo, Paloma [0000-0002-3698-8896], De Cal Cortina, Antonieta [0000-0002-7725-7782], Larena, Inmaculada, Villarino, María, Melgarejo, Paloma, and De Cal Cortina, Antonieta
Abstract: Cherry brown rot caused by Monilinialaxa was observed and estimated in organic cherry orchard located in the Jerte Valley between 2013 and 2018 (Cáceres, Spain). Climatic variables were collected from this orchard and also from a nearby weather station. The primary inoculum of the pathogen recorded in March was detected in overwintered mummified fruits, ground mummies, and necrotic twigs and was a function of the average temperature of the previous three months (December, January, and February). The first symptoms of brown rot could be observed on flowers until fruit set in April. The months of March and April were identified as the critical period for cherry brown-rot development. A significant positive correlation was identified between brown rot observed at harvest and the mean number of consecutive days in each fortnight of March and April when the percent relative humidity was above 80%. Brown-rot incidence observed over the 6 years ranged from 0 to 38%. More than 11 days with relative humidity >80% in each fortnight of critical period would mean 100% of cherry brown rot at harvest. A forecasting model could be used to predict brown rot infection in Jerte Valley cherries.
Published: 2021

42. Effect of SGLT2 inhibitors on stroke and atrial fibrillation in diabetic kidney disease: Results from the CREDENCE trial and meta-analysis

Author: Zhou, Z, Jardine, M, Li, Q, Neuen, B, Cannon, C, De Zeeuw, D, Edwards, R, Levin, A, Mahaffey, K, Perkovic, V, Neal, B, Lindley, R, Guerrero, R, Aizenberg, D, Albisu, J, Alvarisqueta, A, Bartolacci, I, Berli, M, Bordonava, A, Calella, P, Cantero, M, Cartasegna, L, Cercos, E, Coloma, G, Colombo, H, Commendatore, V, Cuadrado, J, Cuneo, C, Cusumano, A, Douthat, W, Dran, R, Farias, E, Fernandez, M, Finkelstein, H, Fragale, G, Fretes, J, Garcia, N, Gastaldi, A, Gelersztein, E, Glenny, J, Gonzalez, J, Del Carmen Gonzalez Colaso, P, Goycoa, C, Greloni, G, Guinsburg, A, Hermida, S, Juncos, L, Klyver, M, Kraft, F, Krynski, F, Lanchiotti, P, De La Fuente, R, Marchetta, N, Mele, P, Nicolai, S, Novoa, P, Orio, S, Otreras, F, Oviedo, A, Raffaele, P, Resk, J, Rista, L, Papini, N, Sala, J, Santos, J, Schiavi, L, Sessa, H, Casabella, T, Ulla, M, Valdez, M, Vallejos, A, Villarino, A, Visco, V, Wassermann, A, Zaidman, C, Cheung, N, Droste, C, Fraser, I, Johnson, D, Mah, P, Nicholls, K, Packham, D, Proietto, J, Roberts, A, Roger, S, Tsang, V, Raduan, R, Da Costa, F, Amodeo, C, Turatti, L, Bregman, R, Sanches, F, Canani, L, Chacra, A, Borges, J, Vencio, S, Da Silva Franco, R, D'Avila, D, De Souza Portes, E, De Souza, P, Deboni, L, Filho, F, Neto, B, Gomes, M, Kohara, S, Keitel, E, Saraiva, J, Lisboa, H, De Carvalho Contieri, F, Milagres, R, Junior, R, De Brito, C, Hissa, M, Sabbag, A, Noronha, I, Panarotto, D, Filho, R, Pereira, M, Saporito, W, Scotton, A, Schuch, T, De Almeida, R, Ramos, C, Felicio, J, Thome, F, Hachmann, J, Yamada, S, Hayashida, C, Petry, T, Zanella, M, Andreeva, V, Angelova, A, Dimitrov, S, Genadieva, V, Genova-Hristova, G, Hristozov, K, Kamenov, Z, Koundurdjiev, A, Lozanov, L, Margaritov, V, Nonchev, B, Rangelov, R, Shinkov, A, Temelkova, M, Velichkova, E, Yakov, A, Aggarwal, N, Aronson, R, Bajaj, H, Cherney, D, Chouinard, G, Conway, J, Cournoyer, S, Daroza, G, De Serres, S, Dube, F, Goldenberg, R, Gupta, A, Gupta, M, Henein, S, Khandwala, H, Leiter, L, Madore, F, Mc-Mahon, A, Muirhead, N, Pichette, V, Rabasa-Lhoret, R, Steele, A, Tangri, N, Torshizi, A, Woo, V, Zalunardo, N, Montenegro, M, Jorquera, J, Farina, M, Gajardo, V, Vejar, M, Chen, N, Chen, Q, Gan, S, Kong, Y, Li, D, Li, W, Li, X, Lin, H, Liu, J, Lu, W, Mao, H, Ren, Y, Song, W, Sun, J, Sun, L, Tu, P, Wang, G, Yang, J, Yin, A, Yu, X, Zhao, M, Zheng, H, Mendoza, J, Arcos, E, Avendano, J, Ruiz, J, Ortiz, L, Gonzalez, A, Triana, E, Higuera, J, Malaver, N, De Salazar, D, Rosero, R, Lozano, M, Cometa, L, Valenzuela, A, Alonso, R, Villegas, I, Yupanqui, H, Bartaskova, D, Barton, P, Belobradkova, J, Dohnalova, L, Drasnar, T, Ferkl, R, Halciakova, K, Klokocnikova, V, Kovar, R, Lastuvka, J, Lukac, M, Pesickova, S, Peterka, K, Pumprla, J, Rychlik, I, Saudek, F, Tesar, V, Valis, M, Weiner, P, Zemek, S, Alamartine, E, Borot, S, Cariou, B, Dussol, B, Fauvel, J, Gourdy, P, Klein, A, Le Meur, Y, Penfornis, A, Roussel, R, Saulnier, P, Thervet, E, Zaoui, P, Burst, V, Faghih, M, Faulmann, G, Haller, H, Jerwan-Keim, R, Maxeiner, S, Paschen, B, Plassmann, G, Rose, L, Orellana, R, Haase, F, Diaz, J, Roca, L, Arenales, J, Polo, J, Juarez, E, Csecsei, G, Csiky, B, Danos, P, Deak, L, Dudas, M, Harcsa, E, Keltai, K, Keresztesi, S, Kiss, K, Konyves, L, Major, L, Mileder, M, Molnar, M, Mucsi, J, Oroszlan, T, Ory, I, Paragh, G, Peterfai, E, Petro, G, Revesz, K, Takacs, R, Vangel, S, Vasas, S, Zsom, M, Oomman, A, Raju, S, Dewan, D, Fernando, M, Gopalakrishnan, N, Gracious, N, Alva, H, Jain, D, Keshavamurthy, C, Khullar, D, Sahay, M, Peringat, J, Prasad, N, Rao, K, Reddy, S, Melemadathil, S, Sudhakar, B, Vyasam, R, Bonadonna, R, Castellino, P, Ceriello, A, Chiovato, L, De Cosmo, S, De Nicola, L, Derosa, G, Carlo, A, Cianni, G, Frasca, G, Fuiano, G, Gambaro, G, Garibotto, G, Giorda, C, Malberti, F, Mandreoli, M, Mannucci, E, Orsi, E, Piatti, P, Santoro, D, Sasso, F, Serviddio, G, Stella, A, Trevisan, R, Veronelli, A, Zanoli, L, Akiyama, H, Aoki, H, Asano, A, Iitsuka, T, Kajiyama, S, Kashine, S, Kawada, T, Kodera, T, Kono, H, Koyama, K, Kumeda, Y, Miyauchi, S, Mizuyama, K, Niiya, T, Oishi, H, Ota, S, Sakakibara, T, Takai, M, Tomonaga, O, Tsujimoto, M, Wada, T, Wakasugi, M, Wakida, Y, Watanabe, T, Yamada, M, Yanagida, K, Yanase, T, Yumita, W, Gaupsiene, E, Kozloviene, D, Navickas, A, Urbanaviciene, E, Ghani, R, Kadir, K, Ali, N, Yusof, M, Gan, C, Ismail, M, Kong, W, Lam, S, Lee, L, Lim, S, Loh, C, Manocha, A, Ng, K, Ahmad, N, Ratnasingam, V, Shudim, S, Vengadasalam, P, Munoz, L, Salazar, M, Cruz, J, Soto, M, Ramos, J, Wong, A, Rotter, J, Escalante, T, Sosa, F, Lozano, F, Cervera, L, Baron, P, Ballesteros, C, Rangel, J, Jimenez, L, Santana, S, Flores, F, Molina, H, Ceballos, R, Del Campo Blanco, B, Franco, G, Loza, O, Rocha, C, Vera, G, Castellanos, R, Calcaneo, J, Rosano, M, Pattzi, H, Guzman, J, Joerg, I, Sanchez, S, Mijangos, J, Sanson, P, Tamayo Y Orozco, J, Chavez, E, Cepeda, A, Carrillo, L, Mesa, J, Escobedo, R, Baker, J, Noonan, P, Scott, R, Walker, R, Watson, E, Williams, M, Young, S, Abejuela, Z, Agra, J, Aquitania, G, Caringal, C, Comia, R, Santos, L, Gomez, O, Jimeno, C, Santos, F, Tan, G, Tolentino, M, Yao, C, Yap, Y, Ygpuara, M, Bijata-Bronisz, R, Hotlos, L, Januszewicz, A, Kaczmarek, B, Kaminska, A, Lazuka, L, Madej, A, Mazur, S, Mlodawska-Choluj, D, Nowicki, M, Orlowska-Kowalik, G, Popenda, G, Rewerska, B, Sowinski, D, Angelescu, L, Anghel, V, Avram, R, Busegeanu, M, Cif, A, Cosma, D, Crisan, C, Demian, L, Ferariu, I, Halmagyi, I, Hancu, N, Munteanu, M, Negru, D, Onaca, A, Petrica, L, Popa, A, Ranetti, A, Serafinceanu, C, Toarba, C, Agafyina, A, Barbarash, O, Barysheva, O, Chizhov, D, Dobronravov, V, Dreval, A, Glinkina, I, Grineva, E, Khirmanov, V, Kolmakova, E, Koroleva, T, Kvitkova, L, Marasaev, V, Mkrtumyan, A, Morugova, T, Nagibovich, G, Nagibovich, O, Nedogoda, S, Osipova, I, Raskina, T, Samoylova, Y, Sazonova, O, Shamkhalova, M, Shutemova, E, Shwartz, Y, Uriasyev, O, Vorobyev, S, Zateyshchikova, A, Zateyshshikov, D, Zykova, T, Antic, S, Djordjevic, M, Kendereski, A, Lalic, K, Lalic, N, Popovic-Radinovic, V, Babikova, J, Benusova, O, Buganova, I, Culak, J, Dzupina, A, Dzuponova, J, Fulop, P, Ilavska, A, Martinka, E, Ochodnicka, Z, Pella, D, Smatanova, I, Ahmed, F, Badat, A, Breedt, J, Distiller, L, Govender, V, Govender, R, Joshi, M, Jurgens, J, Latiff, G, Lombard, L, Mookadam, M, Ngcakani, N, Nortje, H, Oosthuizen, H, Pillay-Ramaya, L, Prozesky, H, Reddy, J, Rheeder, P, Seeber, M, Chae, D, Cho, Y, Jeong, I, Kim, S, Kim, Y, Kwon, H, Kwon, M, Lee, B, Lee, J, Lee, M, Nam, M, Oh, K, Park, C, Park, S, Yoon, K, Garcia, P, Mercadal, L, Barrios, C, Castro, F, Guldris, S, Lopez, M, De Los Rios, J, Fresnedo, G, Serrano, A, Garcia, I, Martinez, F, Gimeno, J, Mendoza, M, Marin, T, Portillo, C, Vila, M, Torres, M, Iglesias, J, Perez, J, Vera, M, Simon, M, Canonge, R, Riera, M, Madueno, F, Plaza, M, Chang, C, Chuang, L, Hsia, T, Hsieh, C, Hwang, S, Lin, C, Lu, Y, Sheu, W, Barna, O, Bilyk, S, Botsyurko, V, Dudar, I, Fushtey, I, Godlevska, O, Golovchenko, O, Gyrina, O, Kazmirchuk, A, Kolesnyk, M, Komisarenko, I, Korzh, O, Kravchun, N, Legun, O, Mankovskyy, B, Martynyuk, L, Mostovoy, Y, Pashkovska, N, Pererva, L, Pertseva, T, Samoylov, O, Smirnov, I, Svyshchenko, Y, Tomashkevych, H, Topchii, I, Tryshchuk, N, Tseluyko, V, Vizir, V, Vlasenko, M, Zlova, T, Zub, L, Abusnana, S, Railey, M, Abouglila, K, Ainsworth, P, Ali, Z, Arutchelvam, V, Barnard, M, Bellary, S, Davies, E, Davies, M, Davies, S, Dawson, A, Kossi, M, English, P, Fraser, D, Gnudi, L, Gunstone, A, Hall, T, Hanif, W, Jackson, A, Johnson, A, Joseph, F, Krishnan, S, Kumwenda, M, Macdougall, I, Nixon, P, O'Hare, J, Philip, S, Ramtoola, S, Saxena, M, Sennik, D, Simon, G, Singh, B, Stephens, J, Strzelecka, A, Symonds, R, Turner, W, Wahba, M, Wakeling, J, Wheeler, D, Winocour, P, Abdallah, J, Abdullah, R, Abramowitz, M, Acosta, I, Aiello, J, Akright, L, Akyea-Djamson, A, Alappan, R, Alicic, R, Al-Karadsheh, A, Allison, D, Arauz-Pacheco, C, Arfeen, S, Arif, A, Arvind, M, Atray, N, Awad, A, Bakris, G, Barnhill, P, Barranco, E, Barrera, C, Beacom, M, Behara, V, Belo, D, Bentley-Lewis, R, Berenguer, R, Bermudez, L, Bernardo, M, Biscoveanu, M, Bowman-Stroud, C, Brandon, D, Brusco, O, Busch, R, Canaan, Y, Chilito, A, Christensen, T, Christiano, C, Christofides, E, Chuateco, C, Cohen, K, Cohen, R, Cohen-Stein, D, Cook, C, Coyne, D, Daboul, N, Darwish, R, Daswani, A, Deck, K, Desouza, C, Dev, D, Dhillon, M, Dua, S, Eder, F, Elosegui, A, El-Shahawy, M, Ervin, J, Esquenazi, A, Evans, J, Fishbane, S, Frias, J, Galindo-Ramos, E, Galphin, C, Ghazi, A, Gonzalez, E, Gorson, D, Gowda, A, Greco, B, Grubb, S, Gulati, R, Hammoud, J, Handelsman, S, Hartman, I, Hershon, K, Hiser, D, Hon, G, Jacob, R, Jaime, M, Jamal, A, Kaupke, C, Keightley, G, Kern, E, Khanna, R, Khitan, Z, Kopyt, N, Kovesdy, C, Krishna, G, Kropp, J, Kumar, A, Kumar, J, Kumar, N, Kusnir, J, Lane, W, Lawrence, M, Lehrner, L, Lentz, J, Levinson, D, Lewis, D, Liss, K, Maddux, A, Maheshwari, H, Mandayam, S, Marar, I, Mehta, B, Middleton, J, Mordujovich, J, Moreda, R, Moustafa, M, Trenche, S, Narayanan, M, Narvarte, J, Nassar, T, Newman, G, Nichol, B, Nicol, P, Nisnisan, J, Nossuli, A, Obialo, C, Olelewe, S, Oliver, M, O'Shaughnessy, A, Padron, J, Pankhaniya, R, Parker, R, Patel, D, Patel, G, Patel, N, Pavon, H, Perez, A, Perez, C, Perlman, A, Pettis, K, Pharr, W, Phillips, A, Purighalla, R, Quesada-Suarez, L, Ranjan, R, Rastogi, S, Rendell, M, Rich, L, Robinson, M, Rodriguez, H, Rosas, S, Saba, F, Sankaram, R, Sarin, R, Schreiman, R, Scott, D, Sekkarie, M, Sensenbrenner, J, Shakeel, M, Shanik, M, Shaw, S, Smith, S, Solomon, R, Sprague, A, Spry, L, Suchinda, P, Sultan, S, Surampudi, P, Sussman, S, Tan, A, Terrelonge, A, Thompson, M, Trespalacios, F, Trippe, B, Trueba, P, Twahirwa, M, Updegrove, J, Van Buren, P, Vannorsdall, M, Varghese, F, Velasquez-Mieyer, P, Ventrapragada, S, Vukotic, G, Wadud, K, Warren, M, Watson, H, Watts, R, Weiner, D, Welker, J, Welsh, J, Williams, S, Zaniewski-Singh, M, Zhou Z., Jardine M. J., Li Q., Neuen B. L., Cannon C. P., De Zeeuw D., Edwards R., Levin A., Mahaffey K. W., Perkovic V., Neal B., Lindley R. I., Guerrero R. A. A., Aizenberg D., Albisu J. P., Alvarisqueta A., Bartolacci I., Berli M. A., Bordonava A., Calella P., Cantero M. C., Cartasegna L. R., Cercos E., Coloma G. C., Colombo H., Commendatore V., Cuadrado J., Cuneo C. A., Cusumano A. M., Douthat W. G., Dran R. D., Farias E., Fernandez M. F., Finkelstein H., Fragale G., Fretes J. O., Garcia N. H., Gastaldi A., Gelersztein E., Glenny J. A., Gonzalez J. P., Del Carmen Gonzalez Colaso P., Goycoa C., Greloni G. C., Guinsburg A., Hermida S., Juncos L. I., Klyver M. I., Kraft F., Krynski F., Lanchiotti P. V., De La Fuente R. A. L., Marchetta N., Mele P., Nicolai S., Novoa P. A., Orio S. I., Otreras F., Oviedo A., Raffaele P., Resk J. H., Rista L., Papini N. R., Sala J., Santos J. C., Schiavi L. B., Sessa H., Casabella T. S., Ulla M. R., Valdez M., Vallejos A., Villarino A., Visco V. E., Wassermann A., Zaidman C. J., Cheung N. W., Droste C., Fraser I., Johnson D., Mah P. M., Nicholls K., Packham D., Proietto J., Roberts A., Roger S., Tsang V., Raduan R. A., Da Costa F. A. A., Amodeo C., Turatti L. A. A., Bregman R., Sanches F. C. C., Canani L. H., Chacra A. R., Borges J. L. C., Vencio S. A. C., Da Silva Franco R. J., D'Avila D., De Souza Portes E., De Souza P., Deboni L. M., Filho F. F., Neto B. G., Gomes M., Kohara S. K., Keitel E., Saraiva J. F. K., Lisboa H. R. K., De Carvalho Contieri F. L., Milagres R., Junior R. M., De Brito C. M., Hissa M. N., Sabbag A. R. N., Noronha I., Panarotto D., Filho R. P., Pereira M. A., Saporito W., Scotton A. S., Schuch T., De Almeida R. S., Ramos C. S., Felicio J. S., Thome F., Hachmann J. C. T., Yamada S., Hayashida C. Y., Petry T. B. Z., Zanella M. T., Andreeva V., Angelova A., Dimitrov S., Genadieva V., Genova-Hristova G., Hristozov K., Kamenov Z., Koundurdjiev A., Lozanov L., Margaritov V., Nonchev B., Rangelov R., Shinkov A., Temelkova M., Velichkova E., Yakov A., Aggarwal N., Aronson R., Bajaj H., Cherney D., Chouinard G., Conway J., Cournoyer S., DaRoza G., De Serres S., Dube F., Goldenberg R., Gupta A., Gupta M., Henein S., Khandwala H., Leiter L., Madore F., Mc-Mahon A., Muirhead N., Pichette V., Rabasa-Lhoret R., Steele A., Tangri N., Torshizi A., Woo V., Zalunardo N., Montenegro M. A. F., Jorquera J. G. G., Farina M. M., Gajardo V. S., Vejar M., Chen N., Chen Q., Gan S., Kong Y., Li D., Li W., Li X., Lin H., Liu J., Lu W., Mao H., Ren Y., Song W., Sun J., Sun L., Tu P., Wang G., Yang J., Yin A., Yu X., Zhao M., Zheng H., Mendoza J. L. A., Arcos E., Avendano J., Ruiz J. E. A. D., Ortiz L. H. G., Gonzalez A., Triana E. H., Higuera J. D., Malaver N., De Salazar D. I. M., Rosero R., Lozano M. A. T., Cometa L. V., Valenzuela A., Alonso R. D. V., Villegas I., Yupanqui H., Bartaskova D., Barton P., Belobradkova J., Dohnalova L., Drasnar T., Ferkl R., Halciakova K., Klokocnikova V., Kovar R., Lastuvka J., Lukac M., Pesickova S., Peterka K., Pumprla J., Rychlik I., Saudek F., Tesar V., Valis M., Weiner P., Zemek S., Alamartine E., Borot S., Cariou B., Dussol B., Fauvel J. -P., Gourdy P., Klein A., Le Meur Y., Penfornis A., Roussel R., Saulnier P. -J., Thervet E., Zaoui P., Burst V., Faghih M., Faulmann G., Haller H., Jerwan-Keim R., Maxeiner S., Paschen B., Plassmann G., Rose L., Orellana R. A. G., Haase F. P., Diaz J. P. M., Roca L. A. R., Arenales J. A. S., Polo J. V. S., Juarez E. T., Csecsei G., Csiky B., Danos P., Deak L., Dudas M., Harcsa E., Keltai K., Keresztesi S., Kiss K., Konyves L., Major L., Mileder M., Molnar M., Mucsi J., Oroszlan T., Ory I., Paragh G., Peterfai E., Petro G., Revesz K., Takacs R., Vangel S., Vasas S., Zsom M., Oomman A., Raju S. B., Dewan D., Fernando M. E., Gopalakrishnan N., Gracious N., Alva H., Jain D., Keshavamurthy C. B., Khullar D., Sahay M., Peringat J., Prasad N., Rao K. S., Reddy S., Melemadathil S., Sudhakar B., Vyasam R. C., Bonadonna R., Castellino P., Ceriello A., Chiovato L., De Cosmo S., De Nicola L., Derosa G., Carlo A. D., Cianni G. D., Frasca G., Fuiano G., Gambaro G., Garibotto G., Giorda C., Malberti F., Mandreoli M., Mannucci E., Orsi E., Piatti P., Santoro D., Sasso F. C., Serviddio G., Stella A., Trevisan R., Veronelli A. M., Zanoli L., Akiyama H., Aoki H., Asano A., Iitsuka T., Kajiyama S., Kashine S., Kawada T., Kodera T., Kono H., Koyama K., Kumeda Y., Miyauchi S., Mizuyama K., Niiya T., Oishi H., Ota S., Sakakibara T., Takai M., Tomonaga O., Tsujimoto M., Wada T., Wakasugi M., Wakida Y., Watanabe T., Yamada M., Yanagida K., Yanase T., Yumita W., Gaupsiene E., Kozloviene D., Navickas A., Urbanaviciene E., Ghani R. A., Kadir K. A., Ali N., Yusof M. D. C., Gan C. L., Ismail M., Kong W. Y., Lam S. W., Lee L. Y., Lim S. K., Loh C. L., Manocha A. B., Ng K. S., Ahmad N. N. F. N., Ratnasingam V., Shudim S. S. B., Vengadasalam P., Munoz L. D. A., Salazar M. A., Cruz J. B., Soto M. B., Ramos J. C., Wong A. C., Rotter J. R. C., Escalante T. D., Sosa F. E. E., Lozano F. F., Cervera L. F. F., Baron P. F., Ballesteros C. G., Rangel J. D. G., Jimenez L. E. H., Santana S. S. I., Flores F. J., Molina H. L., Ceballos R. I. L., Del Campo Blanco B. M., Franco G. M., Loza O. T. M., Rocha C. M., Vera G. O., Castellanos R. O., Calcaneo J. P., Rosano M. A. R., Pattzi H. R., Guzman J. R., Joerg I. E. R., Sanchez S. B. S., Mijangos J. H. S., Sanson P. S., Tamayo Y Orozco J. A., Chavez E. T., Cepeda A. V., Carrillo L. V., Mesa J. V., Escobedo R. Z., Baker J., Noonan P., Scott R., Walker R., Watson E., Williams M., Young S., Abejuela Z., Agra J., Aquitania G., Caringal C., Comia R. S., Santos L. D., Gomez O., Jimeno C., Santos F., Tan G., Tolentino M., Yao C., Yap Y. E., Ygpuara M. D. L., Bijata-Bronisz R., Hotlos L., Januszewicz A., Kaczmarek B., Kaminska A., Lazuka L., Madej A., Mazur S., Mlodawska-Choluj D., Nowicki M., Orlowska-Kowalik G., Popenda G., Rewerska B., Sowinski D., Angelescu L. M., Anghel V., Avram R. -I., Busegeanu M. -M., Cif A., Cosma D., Crisan C., Demian L. D., Ferariu I. E., Halmagyi I., Hancu N., Munteanu M., Negru D., Onaca A. G., Petrica L., Popa A. R., Ranetti A. -E., Serafinceanu C., Toarba C., Agafyina A., Barbarash O., Barysheva O., Chizhov D., Dobronravov V., Dreval A., Glinkina I., Grineva E., Khirmanov V., Kolmakova E., Koroleva T., Kvitkova L., Marasaev V., Mkrtumyan A., Morugova T., Nagibovich G., Nagibovich O., Nedogoda S., Osipova I., Raskina T., Samoylova Y., Sazonova O., Shamkhalova M., Shutemova E., Shwartz Y., Uriasyev O., Vorobyev S., Zateyshchikova A., Zateyshshikov D., Zykova T., Antic S., Djordjevic M., Kendereski A., Lalic K., Lalic N., Popovic-Radinovic V., Babikova J., Benusova O., Buganova I., Culak J., Dzupina A., Dzuponova J., Fulop P., Ilavska A., Martinka E., Ochodnicka Z., Pella D., Smatanova I., Ahmed F., Badat A., Breedt J., Distiller L., Govender V., Govender R., Joshi M., Jurgens J., Latiff G., Lombard L., Mookadam M., Ngcakani N., Nortje H., Oosthuizen H., Pillay-Ramaya L., Prozesky H., Reddy J., Rheeder P., Seeber M., Chae D. -W., Cho Y. M., Jeong I. -K., Kim S. G., Kim Y. H., Kwon H. -S., Kwon M. J., Lee B. -W., Lee J., Lee M. -K., Nam M. -S., Oh K. -H., Park C. -Y., Park S. -H., Yoon K. H., Garcia P. A., Mercadal L. A., Barrios C., Castro F. C., Guldris S. C., Lopez M. D., De Los Rios J. E., Fresnedo G. F., Serrano A. G., Garcia I., Martinez F. J. G., Gimeno J. E. J., Mendoza M. L., Marin T. M., Portillo C. M., Vila M. A. M., Torres M. M., Iglesias J. N., Perez J. P., Vera M. P., Perez J. M. P., Simon M. A. Q., Canonge R. S., Gonzalez A. S., Riera M. T., Madueno F. J. T., Plaza M. V., Chang C. -T., Chuang L. -M., Hsia T. -L., Hsieh C. -H., Hwang S. -J., Lin C. -C., Lu Y. -C., Sheu W. H. -H., Barna O., Bilyk S. D., Botsyurko V., Dudar I., Fushtey I., Godlevska O., Golovchenko O., Gyrina O., Kazmirchuk A., Kolesnyk M., Komisarenko I., Korzh O., Kravchun N., Legun O., Mankovskyy B., Martynyuk L., Mostovoy Y., Pashkovska N., Pererva L., Pertseva T., Samoylov O., Smirnov I., Svyshchenko Y., Tomashkevych H., Topchii I., Tryshchuk N., Tseluyko V., Vizir V., Vlasenko M., Zlova T., Zub L., Abusnana S., Railey M., Abouglila K., Ainsworth P., Ali Z., Arutchelvam V., Barnard M., Bellary S., Davies E., Davies M., Davies S., Dawson A., Kossi M. E., English P., Fraser D., Gnudi L., Gunstone A., Hall T., Hanif W., Jackson A., Johnson A., Joseph F., Krishnan S., Kumwenda M., MacDougall I., Nixon P., O'Hare J., Philip S., Ramtoola S., Saxena M., Sennik D., Simon G., Singh B., Stephens J., Strzelecka A., Symonds R., Turner W., Wahba M., Wakeling J., Wheeler D., Winocour P., Abdallah J., Abdullah R., Abramowitz M., Acosta I., Aiello J., Akright L., Akyea-Djamson A., Alappan R., Alicic R., Al-Karadsheh A., Allison D. C., Arauz-Pacheco C., Arfeen S., Arif A., Arvind M., Atray N., Awad A., Bakris G., Barnhill P., Barranco E., Barrera C., Beacom M., Behara V., Belo D., Bentley-Lewis R., Berenguer R., Bermudez L., Bernardo M., Biscoveanu M., Bowman-Stroud C., Brandon D., Brusco O., Busch R., Canaan Y., Chilito A., Christensen T., Christiano C., Christofides E., Chuateco C., Cohen K., Cohen R., Cohen-Stein D., Cook C., Coyne D., Daboul N., Darwish R., Daswani A., Deck K., Desouza C., Dev D., Dhillon M., Dua S., Eder F., Elosegui A. 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Pashkovska, N, Pererva, L, Pertseva, T, Samoylov, O, Smirnov, I, Svyshchenko, Y, Tomashkevych, H, Topchii, I, Tryshchuk, N, Tseluyko, V, Vizir, V, Vlasenko, M, Zlova, T, Zub, L, Abusnana, S, Railey, M, Abouglila, K, Ainsworth, P, Ali, Z, Arutchelvam, V, Barnard, M, Bellary, S, Davies, E, Davies, M, Davies, S, Dawson, A, Kossi, M, English, P, Fraser, D, Gnudi, L, Gunstone, A, Hall, T, Hanif, W, Jackson, A, Johnson, A, Joseph, F, Krishnan, S, Kumwenda, M, Macdougall, I, Nixon, P, O'Hare, J, Philip, S, Ramtoola, S, Saxena, M, Sennik, D, Simon, G, Singh, B, Stephens, J, Strzelecka, A, Symonds, R, Turner, W, Wahba, M, Wakeling, J, Wheeler, D, Winocour, P, Abdallah, J, Abdullah, R, Abramowitz, M, Acosta, I, Aiello, J, Akright, L, Akyea-Djamson, A, Alappan, R, Alicic, R, Al-Karadsheh, A, Allison, D, Arauz-Pacheco, C, Arfeen, S, Arif, A, Arvind, M, Atray, N, Awad, A, Bakris, G, Barnhill, P, Barranco, E, Barrera, C, Beacom, M, Behara, V, Belo, D, Bentley-Lewis, R, Berenguer, R, Bermudez, L, 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B, Nicol, P, Nisnisan, J, Nossuli, A, Obialo, C, Olelewe, S, Oliver, M, O'Shaughnessy, A, Padron, J, Pankhaniya, R, Parker, R, Patel, D, Patel, G, Patel, N, Pavon, H, Perez, A, Perez, C, Perlman, A, Pettis, K, Pharr, W, Phillips, A, Purighalla, R, Quesada-Suarez, L, Ranjan, R, Rastogi, S, Rendell, M, Rich, L, Robinson, M, Rodriguez, H, Rosas, S, Saba, F, Sankaram, R, Sarin, R, Schreiman, R, Scott, D, Sekkarie, M, Sensenbrenner, J, Shakeel, M, Shanik, M, Shaw, S, Smith, S, Solomon, R, Sprague, A, Spry, L, Suchinda, P, Sultan, S, Surampudi, P, Sussman, S, Tan, A, Terrelonge, A, Thompson, M, Trespalacios, F, Trippe, B, Trueba, P, Twahirwa, M, Updegrove, J, Van Buren, P, Vannorsdall, M, Varghese, F, Velasquez-Mieyer, P, Ventrapragada, S, Vukotic, G, Wadud, K, Warren, M, Watson, H, Watts, R, Weiner, D, Welker, J, Welsh, J, Williams, S, Zaniewski-Singh, M, Zhou Z., Jardine M. J., Li Q., Neuen B. L., Cannon C. P., De Zeeuw D., Edwards R., Levin A., Mahaffey K. W., Perkovic V., Neal B., Lindley R. I., Guerrero R. A. A., Aizenberg D., Albisu J. P., Alvarisqueta A., Bartolacci I., Berli M. A., Bordonava A., Calella P., Cantero M. C., Cartasegna L. R., Cercos E., Coloma G. C., Colombo H., Commendatore V., Cuadrado J., Cuneo C. A., Cusumano A. M., Douthat W. G., Dran R. D., Farias E., Fernandez M. F., Finkelstein H., Fragale G., Fretes J. O., Garcia N. H., Gastaldi A., Gelersztein E., Glenny J. A., Gonzalez J. P., Del Carmen Gonzalez Colaso P., Goycoa C., Greloni G. C., Guinsburg A., Hermida S., Juncos L. I., Klyver M. I., Kraft F., Krynski F., Lanchiotti P. V., De La Fuente R. A. L., Marchetta N., Mele P., Nicolai S., Novoa P. A., Orio S. I., Otreras F., Oviedo A., Raffaele P., Resk J. H., Rista L., Papini N. R., Sala J., Santos J. C., Schiavi L. B., Sessa H., Casabella T. S., Ulla M. R., Valdez M., Vallejos A., Villarino A., Visco V. E., Wassermann A., Zaidman C. J., Cheung N. W., Droste C., Fraser I., Johnson D., Mah P. M., Nicholls K., Packham D., Proietto J., Roberts A., Roger S., Tsang V., Raduan R. A., Da Costa F. A. A., Amodeo C., Turatti L. A. A., Bregman R., Sanches F. C. C., Canani L. H., Chacra A. R., Borges J. L. C., Vencio S. A. C., Da Silva Franco R. J., D'Avila D., De Souza Portes E., De Souza P., Deboni L. M., Filho F. F., Neto B. G., Gomes M., Kohara S. K., Keitel E., Saraiva J. F. K., Lisboa H. R. K., De Carvalho Contieri F. L., Milagres R., Junior R. M., De Brito C. M., Hissa M. N., Sabbag A. R. N., Noronha I., Panarotto D., Filho R. P., Pereira M. A., Saporito W., Scotton A. S., Schuch T., De Almeida R. S., Ramos C. S., Felicio J. S., Thome F., Hachmann J. C. T., Yamada S., Hayashida C. Y., Petry T. B. Z., Zanella M. T., Andreeva V., Angelova A., Dimitrov S., Genadieva V., Genova-Hristova G., Hristozov K., Kamenov Z., Koundurdjiev A., Lozanov L., Margaritov V., Nonchev B., Rangelov R., Shinkov A., Temelkova M., Velichkova E., Yakov A., Aggarwal N., Aronson R., Bajaj H., Cherney D., Chouinard G., Conway J., Cournoyer S., DaRoza G., De Serres S., Dube F., Goldenberg R., Gupta A., Gupta M., Henein S., Khandwala H., Leiter L., Madore F., Mc-Mahon A., Muirhead N., Pichette V., Rabasa-Lhoret R., Steele A., Tangri N., Torshizi A., Woo V., Zalunardo N., Montenegro M. A. F., Jorquera J. G. G., Farina M. M., Gajardo V. S., Vejar M., Chen N., Chen Q., Gan S., Kong Y., Li D., Li W., Li X., Lin H., Liu J., Lu W., Mao H., Ren Y., Song W., Sun J., Sun L., Tu P., Wang G., Yang J., Yin A., Yu X., Zhao M., Zheng H., Mendoza J. L. A., Arcos E., Avendano J., Ruiz J. E. A. D., Ortiz L. H. G., Gonzalez A., Triana E. H., Higuera J. D., Malaver N., De Salazar D. I. M., Rosero R., Lozano M. A. T., Cometa L. V., Valenzuela A., Alonso R. D. V., Villegas I., Yupanqui H., Bartaskova D., Barton P., Belobradkova J., Dohnalova L., Drasnar T., Ferkl R., Halciakova K., Klokocnikova V., Kovar R., Lastuvka J., Lukac M., Pesickova S., Peterka K., Pumprla J., Rychlik I., Saudek F., Tesar V., Valis M., Weiner P., Zemek S., Alamartine E., Borot S., Cariou B., Dussol B., Fauvel J. -P., Gourdy P., Klein A., Le Meur Y., Penfornis A., Roussel R., Saulnier P. -J., Thervet E., Zaoui P., Burst V., Faghih M., Faulmann G., Haller H., Jerwan-Keim R., Maxeiner S., Paschen B., Plassmann G., Rose L., Orellana R. A. G., Haase F. P., Diaz J. P. M., Roca L. A. R., Arenales J. A. S., Polo J. V. S., Juarez E. T., Csecsei G., Csiky B., Danos P., Deak L., Dudas M., Harcsa E., Keltai K., Keresztesi S., Kiss K., Konyves L., Major L., Mileder M., Molnar M., Mucsi J., Oroszlan T., Ory I., Paragh G., Peterfai E., Petro G., Revesz K., Takacs R., Vangel S., Vasas S., Zsom M., Oomman A., Raju S. B., Dewan D., Fernando M. E., Gopalakrishnan N., Gracious N., Alva H., Jain D., Keshavamurthy C. B., Khullar D., Sahay M., Peringat J., Prasad N., Rao K. S., Reddy S., Melemadathil S., Sudhakar B., Vyasam R. C., Bonadonna R., Castellino P., Ceriello A., Chiovato L., De Cosmo S., De Nicola L., Derosa G., Carlo A. D., Cianni G. D., Frasca G., Fuiano G., Gambaro G., Garibotto G., Giorda C., Malberti F., Mandreoli M., Mannucci E., Orsi E., Piatti P., Santoro D., Sasso F. C., Serviddio G., Stella A., Trevisan R., Veronelli A. M., Zanoli L., Akiyama H., Aoki H., Asano A., Iitsuka T., Kajiyama S., Kashine S., Kawada T., Kodera T., Kono H., Koyama K., Kumeda Y., Miyauchi S., Mizuyama K., Niiya T., Oishi H., Ota S., Sakakibara T., Takai M., Tomonaga O., Tsujimoto M., Wada T., Wakasugi M., Wakida Y., Watanabe T., Yamada M., Yanagida K., Yanase T., Yumita W., Gaupsiene E., Kozloviene D., Navickas A., Urbanaviciene E., Ghani R. A., Kadir K. A., Ali N., Yusof M. D. C., Gan C. L., Ismail M., Kong W. Y., Lam S. W., Lee L. Y., Lim S. K., Loh C. L., Manocha A. B., Ng K. S., Ahmad N. N. F. N., Ratnasingam V., Shudim S. S. B., Vengadasalam P., Munoz L. D. A., Salazar M. A., Cruz J. B., Soto M. B., Ramos J. C., Wong A. C., Rotter J. R. C., Escalante T. D., Sosa F. E. E., Lozano F. F., Cervera L. F. F., Baron P. F., Ballesteros C. G., Rangel J. D. G., Jimenez L. E. H., Santana S. S. I., Flores F. J., Molina H. L., Ceballos R. I. L., Del Campo Blanco B. M., Franco G. M., Loza O. T. M., Rocha C. M., Vera G. O., Castellanos R. O., Calcaneo J. P., Rosano M. A. R., Pattzi H. R., Guzman J. R., Joerg I. E. R., Sanchez S. B. S., Mijangos J. H. S., Sanson P. S., Tamayo Y Orozco J. A., Chavez E. T., Cepeda A. V., Carrillo L. V., Mesa J. V., Escobedo R. Z., Baker J., Noonan P., Scott R., Walker R., Watson E., Williams M., Young S., Abejuela Z., Agra J., Aquitania G., Caringal C., Comia R. S., Santos L. D., Gomez O., Jimeno C., Santos F., Tan G., Tolentino M., Yao C., Yap Y. E., Ygpuara M. D. L., Bijata-Bronisz R., Hotlos L., Januszewicz A., Kaczmarek B., Kaminska A., Lazuka L., Madej A., Mazur S., Mlodawska-Choluj D., Nowicki M., Orlowska-Kowalik G., Popenda G., Rewerska B., Sowinski D., Angelescu L. M., Anghel V., Avram R. -I., Busegeanu M. -M., Cif A., Cosma D., Crisan C., Demian L. D., Ferariu I. E., Halmagyi I., Hancu N., Munteanu M., Negru D., Onaca A. G., Petrica L., Popa A. R., Ranetti A. -E., Serafinceanu C., Toarba C., Agafyina A., Barbarash O., Barysheva O., Chizhov D., Dobronravov V., Dreval A., Glinkina I., Grineva E., Khirmanov V., Kolmakova E., Koroleva T., Kvitkova L., Marasaev V., Mkrtumyan A., Morugova T., Nagibovich G., Nagibovich O., Nedogoda S., Osipova I., Raskina T., Samoylova Y., Sazonova O., Shamkhalova M., Shutemova E., Shwartz Y., Uriasyev O., Vorobyev S., Zateyshchikova A., Zateyshshikov D., Zykova T., Antic S., Djordjevic M., Kendereski A., Lalic K., Lalic N., Popovic-Radinovic V., Babikova J., Benusova O., Buganova I., Culak J., Dzupina A., Dzuponova J., Fulop P., Ilavska A., Martinka E., Ochodnicka Z., Pella D., Smatanova I., Ahmed F., Badat A., Breedt J., Distiller L., Govender V., Govender R., Joshi M., Jurgens J., Latiff G., Lombard L., Mookadam M., Ngcakani N., Nortje H., Oosthuizen H., Pillay-Ramaya L., Prozesky H., Reddy J., Rheeder P., Seeber M., Chae D. -W., Cho Y. M., Jeong I. -K., Kim S. G., Kim Y. H., Kwon H. -S., Kwon M. J., Lee B. -W., Lee J., Lee M. -K., Nam M. -S., Oh K. -H., Park C. -Y., Park S. -H., Yoon K. H., Garcia P. A., Mercadal L. A., Barrios C., Castro F. C., Guldris S. C., Lopez M. D., De Los Rios J. E., Fresnedo G. F., Serrano A. G., Garcia I., Martinez F. J. G., Gimeno J. E. J., Mendoza M. L., Marin T. M., Portillo C. M., Vila M. A. M., Torres M. M., Iglesias J. N., Perez J. P., Vera M. P., Perez J. M. P., Simon M. A. Q., Canonge R. S., Gonzalez A. S., Riera M. T., Madueno F. J. T., Plaza M. V., Chang C. -T., Chuang L. -M., Hsia T. -L., Hsieh C. -H., Hwang S. -J., Lin C. -C., Lu Y. -C., Sheu W. H. -H., Barna O., Bilyk S. D., Botsyurko V., Dudar I., Fushtey I., Godlevska O., Golovchenko O., Gyrina O., Kazmirchuk A., Kolesnyk M., Komisarenko I., Korzh O., Kravchun N., Legun O., Mankovskyy B., Martynyuk L., Mostovoy Y., Pashkovska N., Pererva L., Pertseva T., Samoylov O., Smirnov I., Svyshchenko Y., Tomashkevych H., Topchii I., Tryshchuk N., Tseluyko V., Vizir V., Vlasenko M., Zlova T., Zub L., Abusnana S., Railey M., Abouglila K., Ainsworth P., Ali Z., Arutchelvam V., Barnard M., Bellary S., Davies E., Davies M., Davies S., Dawson A., Kossi M. E., English P., Fraser D., Gnudi L., Gunstone A., Hall T., Hanif W., Jackson A., Johnson A., Joseph F., Krishnan S., Kumwenda M., MacDougall I., Nixon P., O'Hare J., Philip S., Ramtoola S., Saxena M., Sennik D., Simon G., Singh B., Stephens J., Strzelecka A., Symonds R., Turner W., Wahba M., Wakeling J., Wheeler D., Winocour P., Abdallah J., Abdullah R., Abramowitz M., Acosta I., Aiello J., Akright L., Akyea-Djamson A., Alappan R., Alicic R., Al-Karadsheh A., Allison D. C., Arauz-Pacheco C., Arfeen S., Arif A., Arvind M., Atray N., Awad A., Bakris G., Barnhill P., Barranco E., Barrera C., Beacom M., Behara V., Belo D., Bentley-Lewis R., Berenguer R., Bermudez L., Bernardo M., Biscoveanu M., Bowman-Stroud C., Brandon D., Brusco O., Busch R., Canaan Y., Chilito A., Christensen T., Christiano C., Christofides E., Chuateco C., Cohen K., Cohen R., Cohen-Stein D., Cook C., Coyne D., Daboul N., Darwish R., Daswani A., Deck K., Desouza C., Dev D., Dhillon M., Dua S., Eder F., Elosegui A. M., El-Shahawy M., Ervin J., Esquenazi A., Evans J., Fishbane S., Frias J., Galindo-Ramos E., Galphin C., Ghazi A., Gonzalez E., Gorson D., Gowda A., Greco B., Grubb S., Gulati R., Hammoud J., Handelsman S., Hartman I., Hershon K., Hiser D., Hon G., Jacob R., Jaime M., Jamal A., Kaupke C., Keightley G., Kern E., Khanna R., Khitan Z., Kim S., Kopyt N., Kovesdy C., Krishna G., Kropp J., Kumar A., Kumar J., Kumar N., Kusnir J., Lane W., Lawrence M., Lehrner L., Lentz J., Levinson D., Lewis D., Liss K., Maddux A., Maheshwari H., Mandayam S., Marar I., Mehta B., Middleton J., Mordujovich J., Moreda R., Moustafa M., Trenche S. M., Narayanan M., Narvarte J., Nassar T., Newman G., Nichol B., Nicol P., Nisnisan J., Nossuli A. K., Obialo C., Olelewe S., Oliver M., O'Shaughnessy A., Padron J., Pankhaniya R., Parker R., Patel D., Patel G., Patel N., Pavon H., Perez A., Perez C., Perlman A., Pettis K., Pharr W., Phillips A., Purighalla R., Quesada-Suarez L., Ranjan R., Rastogi S., Rendell M., Rich L., Robinson M., Rodriguez H., Rosas S., Saba F., Sankaram R., Sarin R., Schreiman R., Scott D., Sekkarie M., Sensenbrenner J., Shakeel M., Shanik M., Shaw S., Smith S., Solomon R., Sprague A., Spry L., Suchinda P., Sultan S., Surampudi P., Sussman S., Tan A., Terrelonge A., Thompson M., Trespalacios F., Trippe B., Trueba P., Twahirwa M., Updegrove J., Van Buren P., Vannorsdall M., Varghese F., Velasquez-Mieyer P., Ventrapragada S., Vukotic G., Wadud K., Warren M., Watson H., Watts R., Weiner D., Welker J., Welsh J., Williams S., and Zaniewski-Singh M.
Abstract: BACKGROUND AND PURPOSE: Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-Analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus. METHODS: CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-Analysis. RESULTS: In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55-1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61-1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19-1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20-1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53-1.10]; n=115). The overall effects in the 4 CVOTs combined were: Total stroke (HRpooled, 0.96 [95% CI, 0.82-1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89-1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30-0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49-1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71-0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (45 mL/min/1.73 m2]) subgroup (HRpooled, 0.50 [95% CI, 0.31-0.79]). CONCLUSIONS: Although we found no clear effect
Published: 2021

43. Comparative Genomics Used to Predict Virulence Factors and Metabolic Genes among Monilinia Species

Author: Ministerio de Economía, Industria y Competitividad (España), Generalitat de Catalunya, European Commission, Agència de Gestió d'Ajuts Universitaris i de Recerca, Instituto de Salud Carlos III, Marcet-Houben, Marina [0000-0003-4838-187X], Villarino, María [0000-0002-5635-8146], Vilanova, Laura [0000-0001-7574-9604], De Cal Cortina, Antonieta [0000-0002-7725-7782], van Kan, Jan A L [0000-0003-3563-1550], Usall, J. [0000-0002-0856-3508], Gabaldón, Toni [0000-0003-0019-1735], Torres, Rosario [0000-0002-1806-9626], Marcet-Houben, Marina, Villarino, María, Vilanova, Laura, De Cal Cortina, Antonieta, van Kan, Jan A L, Usall, J., Gabaldón, Toni, Torres, Rosario, Ministerio de Economía, Industria y Competitividad (España), Generalitat de Catalunya, European Commission, Agència de Gestió d'Ajuts Universitaris i de Recerca, Instituto de Salud Carlos III, Marcet-Houben, Marina [0000-0003-4838-187X], Villarino, María [0000-0002-5635-8146], Vilanova, Laura [0000-0001-7574-9604], De Cal Cortina, Antonieta [0000-0002-7725-7782], van Kan, Jan A L [0000-0003-3563-1550], Usall, J. [0000-0002-0856-3508], Gabaldón, Toni [0000-0003-0019-1735], Torres, Rosario [0000-0002-1806-9626], Marcet-Houben, Marina, Villarino, María, Vilanova, Laura, De Cal Cortina, Antonieta, van Kan, Jan A L, Usall, J., Gabaldón, Toni, and Torres, Rosario
Published: 2021

44. Key insights of urban agriculture for sustainable urban development

Author: Gomez Villarino, María Teresa, Urquijo Reguera, Julia, Gómez Villarino, Miguel, García García, Ana Isabel, Gomez Villarino, María Teresa, Urquijo Reguera, Julia, Gómez Villarino, Miguel, and García García, Ana Isabel
Abstract: Humanity must face the challenge of making viable a world of environmentally, socially, and economically sustainable cities, as it is recognized by the UN 2030 Agenda for Sustainable Development in its Goal 11. This problem is so wide and complex that it does not admit a short-term solution; rather, it must be addressed through measures in a process with long-term results. One of these measures may come from the urban agriculture, applied under the principles of agroecology. Urban agriculture is a complex activity that is currently associated with the idea of multifunctionality, placing emphasis on the various ecosystem services that it generates. However, urban agriculture continues to lack sufficient consideration in urban planning and management. This paper includes a thorough review of the literature on urban agriculture to reveal its benefits, and potential, moving toward the implementation of urban agriculture, under an agroecological approach, in the city.
Published: 2021

45. Implementation of Urban Green Infrastructures in Peri-Urban Areas: A Case Study of Climate Change Mitigation in Madrid

Author: Gomez Villarino, María Teresa, Gómez Villarino, Miguel, Ruiz García, Luis, Gomez Villarino, María Teresa, Gómez Villarino, Miguel, and Ruiz García, Luis
Abstract: Urban areas are critical points that contribute to global warming and are also affected by climate change. One of the measures to move toward urban sustainability and to reduce the effects of climate change is the development of urban green infrastructures. Urban green infrastructures (UGIs) are being increasingly recognized as key providers of ecosystem services in cities, but there is still a lack of support from urban planners. We highlight the potential of urban green infrastructures for sustainable urban planning based on its capacity to mitigate climate change This paper studies the CO2 mitigation potential through a multi-intervention (agricultural and forestry) local case in the peri-urban surroundings of a big European city such as Madrid. We consider two inseparable aspects: the amount of atmospheric CO2-eq reduced through direct carbon uptake of the UGI and also the emission of greenhouse gases due to its implementation and maintenance. The analysis carried out has shown the benefits of urban green infrastructures and their contribution to the mitigation of climate change. The results demonstrate that the absorption capacity of the new urban green infrastructure is much greater than its ecological footprint. Therefore, it contributes to the mitigation of emissions from other urban activities, thus improving urban sustainability.
Published: 2021

46. Entrevista a Toby Miller

Author: Miller, Toby, Miller, Toby, Villarino, Julio, Miller, Toby, Miller, Toby, and Villarino, Julio
Published: 2022

47. MicroRNA-29a attenuates CD8 T cell exhaustion and induces memory-like CD8 T cells during chronic infection.

Author: Stelekati, Erietta, Stelekati, Erietta, Cai, Zhangying, Manne, Sasikanth, Chen, Zeyu, Beltra, Jean-Christophe, Buchness, Lance Alec, Leng, Xuebing, Ristin, Svetlana, Nzingha, Kito, Ekshyyan, Viktoriya, Niavi, Christina, Abdel-Hakeem, Mohamed S, Ali, Mohammed-Alkhatim, Drury, Sydney, Lau, Chi Wai, Gao, Zhen, Ban, Yuguang, Zhou, Simon K, Ansel, K Mark, Kurachi, Makoto, Jordan, Martha S, Villarino, Alejandro V, Ngiow, Shin Foong, Wherry, E John, Stelekati, Erietta, Stelekati, Erietta, Cai, Zhangying, Manne, Sasikanth, Chen, Zeyu, Beltra, Jean-Christophe, Buchness, Lance Alec, Leng, Xuebing, Ristin, Svetlana, Nzingha, Kito, Ekshyyan, Viktoriya, Niavi, Christina, Abdel-Hakeem, Mohamed S, Ali, Mohammed-Alkhatim, Drury, Sydney, Lau, Chi Wai, Gao, Zhen, Ban, Yuguang, Zhou, Simon K, Ansel, K Mark, Kurachi, Makoto, Jordan, Martha S, Villarino, Alejandro V, Ngiow, Shin Foong, and Wherry, E John
Abstract: CD8 T cells mediate protection against intracellular pathogens and tumors. However, persistent antigen during chronic infections or cancer leads to T cell exhaustion, suboptimal functionality, and reduced protective capacity. Despite considerable work interrogating the transcriptional regulation of exhausted CD8 T cells (TEX), the posttranscriptional control of TEX remains poorly understood. Here, we interrogated the role of microRNAs (miRs) in CD8 T cells responding to acutely resolved or chronic viral infection and identified miR-29a as a key regulator of TEX. Enforced expression of miR-29a improved CD8 T cell responses during chronic viral infection and antagonized exhaustion. miR-29a inhibited exhaustion-driving transcriptional pathways, including inflammatory and T cell receptor signaling, and regulated ribosomal biogenesis. As a result, miR-29a fostered a memory-like CD8 T cell differentiation state during chronic infection. Thus, we identify miR-29a as a key regulator of TEX and define mechanisms by which miR-29a can divert exhaustion toward a more beneficial memory-like CD8 T cell differentiation state.
Published: 2022

48. Entrevista a Toby Miller

Author: Miller, Toby, Miller, Toby, Villarino, Julio, Miller, Toby, Miller, Toby, and Villarino, Julio
Published: 2022

49. Evaluación del riesgo de trastornos de la conducta alimentaria en varones que practican deportes de equipo : comparación con una muestra de alto riesgo

Author: Baldó Vela, Daniel, Villarino Marín, Antonio Luis, Bonfanti, Noelia, Baldó Vela, Daniel, Villarino Marín, Antonio Luis, and Bonfanti, Noelia
Abstract: Los trastornos de la conducta alimentaria (TCAs) están caracterizados por la preocupación obsesiva sobre el peso y/o la forma corporal. Los jugadores de deportes de equipo son sistemáticamente excluidos de las poblaciones consideradas de alto riesgo de TCAs. Esta exención podría ser cuestionada por la evidencia de estudios previos que ponen de manifiesto una gran preocupación por la imagen corporal en estos jugadores, el desconocimiento de la prevalencia real de TCAs en el deporte y el elevado riesgo de infra diagnóstico alertado en hombres. Objetivos. Evaluar el riesgo de TCAs en varones que practican algún deporte de equipo federado: detectar sintomatología compatible, comparar los resultados con una población de alto riesgo y conocer las situaciones que implican una mayor vulnerabilidad. Metodología. Se realizó un estudio descriptivo-analítico con una muestra de 276 deportistas varones: 167 jugadores de deportes de equipo y 109 deportistas de modalidades de estética, resistencia y categorías de peso. Los datos fueron recogidos mediante un formulario online que incluyó una hoja de valoración general y cuatro herramientas validadas: Cuestionario de Hábitos Alimentarios del Deportista (CHAD), Test de Actitudes Alimentarias (EAT-40), Inventario de Desórdenes Alimentarios (EDI-2) y Cuestionario sobre la Forma Corporal (BSQ). Todos los sujetos firmaron un consentimiento informado antes de participar en el estudio. El análisis de datos se llevó a cabo mediante el software estadístico IBM SPSS versión 28.0.0. Resultados. El 20,36% de los jugadores de deportes de equipo presentó un cuadro clínico compatible con un diagnóstico de TCA. La Odds ratio no mostró diferencias significativas en la prevalencia de TCAs entre los dos grupos estudiados...
Published: 2022

50. Ultrasonido focal de alta intensidad para el tratamiento de temblor esencial y enfermedad de Parkinson: satisfacción e impacto en la calidad de vida de los pacientes

Author: Villarino Marín,, Antonio Luis, Fernández Hernández, María Ledia, Martínez Martin, Pablo, Hernández Fernández, Frida, Villarino Marín,, Antonio Luis, Fernández Hernández, María Ledia, Martínez Martin, Pablo, and Hernández Fernández, Frida
Abstract: El tratamiento con Ultrasonido Focal de Alta Intensidad es un procedimiento novedoso que une dos conceptos clásicos: realización de termolesión en estructuras profundas del cerebro y neurocirugía funcional. La metodología clásica ha demostrado su beneficio sobre temblor refractario en pacientes con temblor esencial (TE) y sobre signos cardinales en enfermedad de Parkinson (EP). La técnica con HIFU permite realizar tratamiento ablativo focal, sin necesidad de craneotomía, con resultado positivo sobre el temblor y signos cardinales de la EP. Objetivos: probar el impacto del HIFU sobre la clínica y calidad de vida relacionada con la salud (CVRS) de pacientes con TE y EP y analizar aceptabilidad, fiabilidad, consistencia y validez de una escala de satisfacción con la vida y el tratamiento (ESVT-8)..., High Intensity Focused Ultrasound (HIFU) treatment is a novel procedure that unites two classical concepts: performing thermolesion on deep brain structures and functional neurosurgery. The classic methodology has demonstrated its benefit on refractory tremor in patients with essential tremor (ET) and on motor features in Parkinson's disease (PD). The HIFU technique allows focal ablative treatment, without the need for craniotomy, with positive results on tremor and motor features of PD. Main objectives: to test the impact of HIFU on the clinical and health-related quality of life (HRQoL) of patients with ET and PD and to analyze the acceptability, reliability, consistency and validity of a life and treatment satisfaction scale (ESVT-8)...
Published: 2022

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