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12 results on '"Vatsalya, Vatsalya"'

1. Novel paradigms for the gut–brain axis during alcohol withdrawal, withdrawal-associated depression, and craving in patients with alcohol use disorder

Author

Afd Pharmacology, Pharmacology, Vatsalya, Vatsalya, Verster, Joris C., Sagaram, Manasa, Royer, Amor J., Hu, Huirong, Parthasarathy, Ranganathan, Schwandt, Melanie L., Kong, Maiying, Ramchandani, Vijay A., Feng, Wenke, Agrawal, Ruchita, Zhang, Xiang, McClain, Craig J., Afd Pharmacology, Pharmacology, Vatsalya, Vatsalya, Verster, Joris C., Sagaram, Manasa, Royer, Amor J., Hu, Huirong, Parthasarathy, Ranganathan, Schwandt, Melanie L., Kong, Maiying, Ramchandani, Vijay A., Feng, Wenke, Agrawal, Ruchita, Zhang, Xiang, and McClain, Craig J.

Published
2023

2. Sensitivity to Experiencing Alcohol Hangovers: Reconsideration of the 0.11% Blood Alcohol Concentration (BAC) Threshold for Having a Hangover

Author

Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Afd Pharmacology, Afd Pharmacoepi & Clinical Pharmacology, dIRAS RA-1, IRAS OH Toxicology, Verster, Joris C, Kruisselbrink, L Darren, Slot, Karin A, Anogeianaki, Aikaterini, Adams, Sally, Alford, Chris, Arnoldy, Lizanne, Ayre, Elisabeth, Balikji, Stephanie, Benson, Sarah, Bruce, Gillian, Devenney, Lydia E, Frone, Michael R, Gunn, Craig, Heffernan, Thomas, Hensel, Kai O, Hogewoning, Anna, Johnson, Sean J, van Lawick van Pabst, Albertine E, van de Loo, Aurora J A E, Mackus, Marlou, Merlo, Agnese, Murphy, René J L, Owen, Lauren, Palmer, Emily O C, van Rossum, Charmaine J I, Scholey, Andrew, Terpstra, Chantal, Vatsalya, Vatsalya, Vermeulen, Sterre A, van Wijk, Michelle, Stock, Ann-Kathrin, Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Afd Pharmacology, Afd Pharmacoepi & Clinical Pharmacology, dIRAS RA-1, IRAS OH Toxicology, Verster, Joris C, Kruisselbrink, L Darren, Slot, Karin A, Anogeianaki, Aikaterini, Adams, Sally, Alford, Chris, Arnoldy, Lizanne, Ayre, Elisabeth, Balikji, Stephanie, Benson, Sarah, Bruce, Gillian, Devenney, Lydia E, Frone, Michael R, Gunn, Craig, Heffernan, Thomas, Hensel, Kai O, Hogewoning, Anna, Johnson, Sean J, van Lawick van Pabst, Albertine E, van de Loo, Aurora J A E, Mackus, Marlou, Merlo, Agnese, Murphy, René J L, Owen, Lauren, Palmer, Emily O C, van Rossum, Charmaine J I, Scholey, Andrew, Terpstra, Chantal, Vatsalya, Vatsalya, Vermeulen, Sterre A, van Wijk, Michelle, and Stock, Ann-Kathrin

Published
2020

3. Sensitivity to Experiencing Alcohol Hangovers: Reconsideration of the 0.11% Blood Alcohol Concentration (BAC) Threshold for Having a Hangover

Author

Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Afd Pharmacology, Afd Pharmacoepi & Clinical Pharmacology, dIRAS RA-1, IRAS OH Toxicology, Verster, Joris C, Kruisselbrink, L Darren, Slot, Karin A, Anogeianaki, Aikaterini, Adams, Sally, Alford, Chris, Arnoldy, Lizanne, Ayre, Elisabeth, Balikji, Stephanie, Benson, Sarah, Bruce, Gillian, Devenney, Lydia E, Frone, Michael R, Gunn, Craig, Heffernan, Thomas, Hensel, Kai O, Hogewoning, Anna, Johnson, Sean J, van Lawick van Pabst, Albertine E, van de Loo, Aurora J A E, Mackus, Marlou, Merlo, Agnese, Murphy, René J L, Owen, Lauren, Palmer, Emily O C, van Rossum, Charmaine J I, Scholey, Andrew, Terpstra, Chantal, Vatsalya, Vatsalya, Vermeulen, Sterre A, van Wijk, Michelle, Stock, Ann-Kathrin, Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Afd Pharmacology, Afd Pharmacoepi & Clinical Pharmacology, dIRAS RA-1, IRAS OH Toxicology, Verster, Joris C, Kruisselbrink, L Darren, Slot, Karin A, Anogeianaki, Aikaterini, Adams, Sally, Alford, Chris, Arnoldy, Lizanne, Ayre, Elisabeth, Balikji, Stephanie, Benson, Sarah, Bruce, Gillian, Devenney, Lydia E, Frone, Michael R, Gunn, Craig, Heffernan, Thomas, Hensel, Kai O, Hogewoning, Anna, Johnson, Sean J, van Lawick van Pabst, Albertine E, van de Loo, Aurora J A E, Mackus, Marlou, Merlo, Agnese, Murphy, René J L, Owen, Lauren, Palmer, Emily O C, van Rossum, Charmaine J I, Scholey, Andrew, Terpstra, Chantal, Vatsalya, Vatsalya, Vermeulen, Sterre A, van Wijk, Michelle, and Stock, Ann-Kathrin

Published
2020

4. Sensitivity to Experiencing Alcohol Hangovers: Reconsideration of the 0.11% Blood Alcohol Concentration (BAC) Threshold for Having a Hangover

Author

Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Afd Pharmacology, Afd Pharmacoepi & Clinical Pharmacology, dIRAS RA-1, IRAS OH Toxicology, Verster, Joris C, Kruisselbrink, L Darren, Slot, Karin A, Anogeianaki, Aikaterini, Adams, Sally, Alford, Chris, Arnoldy, Lizanne, Ayre, Elisabeth, Balikji, Stephanie, Benson, Sarah, Bruce, Gillian, Devenney, Lydia E, Frone, Michael R, Gunn, Craig, Heffernan, Thomas, Hensel, Kai O, Hogewoning, Anna, Johnson, Sean J, van Lawick van Pabst, Albertine E, van de Loo, Aurora J A E, Mackus, Marlou, Merlo, Agnese, Murphy, René J L, Owen, Lauren, Palmer, Emily O C, van Rossum, Charmaine J I, Scholey, Andrew, Terpstra, Chantal, Vatsalya, Vatsalya, Vermeulen, Sterre A, van Wijk, Michelle, Stock, Ann-Kathrin, Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Afd Pharmacology, Afd Pharmacoepi & Clinical Pharmacology, dIRAS RA-1, IRAS OH Toxicology, Verster, Joris C, Kruisselbrink, L Darren, Slot, Karin A, Anogeianaki, Aikaterini, Adams, Sally, Alford, Chris, Arnoldy, Lizanne, Ayre, Elisabeth, Balikji, Stephanie, Benson, Sarah, Bruce, Gillian, Devenney, Lydia E, Frone, Michael R, Gunn, Craig, Heffernan, Thomas, Hensel, Kai O, Hogewoning, Anna, Johnson, Sean J, van Lawick van Pabst, Albertine E, van de Loo, Aurora J A E, Mackus, Marlou, Merlo, Agnese, Murphy, René J L, Owen, Lauren, Palmer, Emily O C, van Rossum, Charmaine J I, Scholey, Andrew, Terpstra, Chantal, Vatsalya, Vatsalya, Vermeulen, Sterre A, van Wijk, Michelle, and Stock, Ann-Kathrin

Published
2020

5. Exacerbation of Hangover Symptomology Significantly Corresponds with Heavy and Chronic Alcohol Drinking: A Pilot Study

Author

Afd Pharmacology, Pharmacology, Vatsalya, Vatsalya, Hassan, Hamza Z, Kong, Maiying, Stangl, Bethany L, Schwandt, Melanie L, Schmidt-Teron, Veronica Y, Verster, Joris C, Ramchandani, Vijay A, McClain, Craig J, Afd Pharmacology, Pharmacology, Vatsalya, Vatsalya, Hassan, Hamza Z, Kong, Maiying, Stangl, Bethany L, Schwandt, Melanie L, Schmidt-Teron, Veronica Y, Verster, Joris C, Ramchandani, Vijay A, and McClain, Craig J

Published
2019

6. Exacerbation of Hangover Symptomology Significantly Corresponds with Heavy and Chronic Alcohol Drinking: A Pilot Study

Author

Afd Pharmacology, Pharmacology, Vatsalya, Vatsalya, Hassan, Hamza Z, Kong, Maiying, Stangl, Bethany L, Schwandt, Melanie L, Schmidt-Teron, Veronica Y, Verster, Joris C, Ramchandani, Vijay A, McClain, Craig J, Afd Pharmacology, Pharmacology, Vatsalya, Vatsalya, Hassan, Hamza Z, Kong, Maiying, Stangl, Bethany L, Schwandt, Melanie L, Schmidt-Teron, Veronica Y, Verster, Joris C, Ramchandani, Vijay A, and McClain, Craig J

Published
2019

7. Exacerbation of Hangover Symptomology Significantly Corresponds with Heavy and Chronic Alcohol Drinking: A Pilot Study

Author

Afd Pharmacology, Pharmacology, Vatsalya, Vatsalya, Hassan, Hamza Z, Kong, Maiying, Stangl, Bethany L, Schwandt, Melanie L, Schmidt-Teron, Veronica Y, Verster, Joris C, Ramchandani, Vijay A, McClain, Craig J, Afd Pharmacology, Pharmacology, Vatsalya, Vatsalya, Hassan, Hamza Z, Kong, Maiying, Stangl, Bethany L, Schwandt, Melanie L, Schmidt-Teron, Veronica Y, Verster, Joris C, Ramchandani, Vijay A, and McClain, Craig J

Published
2019

8. Proceeding of the 8th alcohol hangover research group meeting

Author

Sub General Pharmacology, Sub BasicPharmacology&Psychopharmacology, Pharmacology, Mackus, Marlou, Adams, Sally, Barzilay, Amir, Benson, Sarah, Blau, Lauren, Iversen, Jacqueline, Johnson, Sean J., Keshavarzian, Ali, Scholey, Andrew, Smith, Gordon S., Trela, Constantine, Vatsalya, Vatsalya, Verster, Joris C., Sub General Pharmacology, Sub BasicPharmacology&Psychopharmacology, Pharmacology, Mackus, Marlou, Adams, Sally, Barzilay, Amir, Benson, Sarah, Blau, Lauren, Iversen, Jacqueline, Johnson, Sean J., Keshavarzian, Ali, Scholey, Andrew, Smith, Gordon S., Trela, Constantine, Vatsalya, Vatsalya, and Verster, Joris C.

Published
2016

9. Proceeding of the 8th alcohol hangover research group meeting

Author

Sub General Pharmacology, Sub BasicPharmacology&Psychopharmacology, Pharmacology, Mackus, Marlou, Adams, Sally, Barzilay, Amir, Benson, Sarah, Blau, Lauren, Iversen, Jacqueline, Johnson, Sean J., Keshavarzian, Ali, Scholey, Andrew, Smith, Gordon S., Trela, Constantine, Vatsalya, Vatsalya, Verster, Joris C., Sub General Pharmacology, Sub BasicPharmacology&Psychopharmacology, Pharmacology, Mackus, Marlou, Adams, Sally, Barzilay, Amir, Benson, Sarah, Blau, Lauren, Iversen, Jacqueline, Johnson, Sean J., Keshavarzian, Ali, Scholey, Andrew, Smith, Gordon S., Trela, Constantine, Vatsalya, Vatsalya, and Verster, Joris C.

Published
2016

10. The Effect of Varenicline on the Neural Processing of Fearful Faces and the Subjective Effects of Alcohol in Heavy Drinkers

Author

Gowin, Joshua L., Vatsalya, Vatsalya, Westman, Jonathan G., Schwandt, Melanie L., Bartlett, Selena, Heilig, Markus, Momenan, Reza, Ramchandani, Vijay A., Gowin, Joshua L., Vatsalya, Vatsalya, Westman, Jonathan G., Schwandt, Melanie L., Bartlett, Selena, Heilig, Markus, Momenan, Reza, and Ramchandani, Vijay A.

Abstract

Background: Pharmacotherapies for alcohol use disorder have been shown to reduce hazardous drinking and improve overall health. The effect sizes for the effectiveness of these medications, however, are small, underscoring the need to expand the range of therapeutics and develop personalized treatment approaches. Recent studies have suggested that varenicline, an 42-nicotinic partial agonist widely used for smoking cessation, can help alcoholics reduce drinking, but the neurocognitive underpinnings of its effectiveness remain largely unexplored. Methods: In this double-blind study, 32 heavy drinkers were randomized to receive varenicline (2 mg/d) or placebo. After 2 weeks of dosing, participants underwent functional MRI scans, during which they viewed images of faces with either neutral or fearful expressions at baseline and following an intravenous alcohol infusion to a target breath alcohol concentration of 80 mg%. Blood oxygen level-dependent (BOLD) response was analyzed with Analysis of Functional Neuroimaging software. Linear mixed-effects models were used to examine the effects of facial expression (fearful vs. neutral) and medication (placebo vs. varenicline) on BOLD response. The effect of medication on measures of subjective response to alcohol was also examined. Results: Results indicated a significant facial expression-by-medication interaction in the left amygdala. The groups showed equivalent activation to neutral faces, but, whereas the placebo group showed increased activation to fearful faces, the varenicline group showed no change in activation. Amygdala activation to fearful faces correlated with number of drinks in the previous 90 days and Obsessive Compulsive Drinking Scale scores. There was no effect of varenicline on subjective response to alcohol. Conclusions: Our results indicate that varenicline may disrupt amygdala response to fearful faces in heavy drinkers. Further, amygdala activation correlated with alcohol consumption, suggesting that t, Funding Agencies|NIAAA Division of Intramural Clinical and Biological Research [Z1AAA000466]; Indiana Alcohol Research Center [NIH P60 AA007611]

Published
2016
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11. Effects of varenicline on neural correlates of alcohol salience in heavy drinkers

Author

Vatsalya, Vatsalya, Gowin, Joshua, Schwandt, Melanie, Momenan, Reza, Coe, Marion, Cooke, Megan, Hommer, Daniel, Bartlett, Selena, Heilig, Markus, Ramchandani, Vijay, Vatsalya, Vatsalya, Gowin, Joshua, Schwandt, Melanie, Momenan, Reza, Coe, Marion, Cooke, Megan, Hommer, Daniel, Bartlett, Selena, Heilig, Markus, and Ramchandani, Vijay

Abstract

Background: Preclinical and emerging clinical evidence indicates that varenicline, a nicotinic partial agonist approved for smoking cessation, attenuates alcohol seeking and consumption. Reductions of alcohol craving have been observed under varenicline treatment and suggest effects of the medication on alcohol reward processing, but this hypothesis remains untested. Methods: In this double-blind, placebo-controlled randomized experimental medicine study, 29 heavy drinkers underwent a functional magnetic resonance imaging scan after 2 weeks of varenicline (2 mg/d) or placebo administration. During functional magnetic resonance imaging, participants performed the Alcohol-Food Incentive Delay task, where they could earn points for snacks or alcohol. At baseline and after 3 weeks of medication, participants underwent intravenous alcohol self-administration sessions in the laboratory. Results: During the functional magnetic resonance imaging scan, participants in the varenicline group (N = 17) reported lower feelings of happiness and excitement on subjective mood scales when anticipating alcohol reward compared with the placebo group (N = 12). Linear mixed effects analysis revealed that anticipation of alcohol reward was associated with significant blood oxygen level dependent activation of the ventral striatum, amygdala, and posterior insula in the placebo group; this activation was attenuated in the varenicline group. The varenicline group showed no difference in intravenous alcohol self-administration relative to the placebo group for either session. Participants with higher insula activation when anticipating alcohol reward showed higher alcohol self-administration behavior across groups. Conclusions: Our findings suggest that varenicline decreases blood oxygen level dependent activation in striato-corticolimbic regions associated with motivation and incentive salience of alcohol in heavy drinkers. This mechanism may underlie the clinical effectiveness of vareniclin

Published
2015

12. Sensitivity to Experiencing Alcohol Hangovers: Reconsideration of the 0.11% Blood Alcohol Concentration (BAC) Threshold for Having a Hangover

Author

Verster, Joris C., Kruisselbrink, L. Darren, Slot, Karin A., Anogeianaki, Aikaterini, Adams, Sally, Alford, Chris, Arnoldy, Lizanne, Ayre, Elisabeth, Balikji, Stephanie, Benson, Sarah, Bruce, Gillian, Devenney, Lydia E., Frone, Michael R., Gunn, Craig, Heffernan, Thomas, Hensel, Kai O., Hogewoning, Anna, Johnson, Sean J., van Lawick van Pabst, Albertine E., van de Loo, Aurora J.A.E., Mackus, Marlou, Merlo, Agnese, Murphy, René J.L., Owen, Lauren, Palmer, Emily O.C., van Rossum, Charmaine J.I., Scholey, Andrew, Terpstra, Chantal, Vatsalya, Vatsalya, Vermeulen, Sterre A., van Wijk, Michelle, Stock, Ann-Kathrin, Verster, Joris C., Kruisselbrink, L. Darren, Slot, Karin A., Anogeianaki, Aikaterini, Adams, Sally, Alford, Chris, Arnoldy, Lizanne, Ayre, Elisabeth, Balikji, Stephanie, Benson, Sarah, Bruce, Gillian, Devenney, Lydia E., Frone, Michael R., Gunn, Craig, Heffernan, Thomas, Hensel, Kai O., Hogewoning, Anna, Johnson, Sean J., van Lawick van Pabst, Albertine E., van de Loo, Aurora J.A.E., Mackus, Marlou, Merlo, Agnese, Murphy, René J.L., Owen, Lauren, Palmer, Emily O.C., van Rossum, Charmaine J.I., Scholey, Andrew, Terpstra, Chantal, Vatsalya, Vatsalya, Vermeulen, Sterre A., van Wijk, Michelle, and Stock, Ann-Kathrin

Abstract

The 2010 Alcohol Hangover Research Group consensus paper defined a cutoff blood alcohol concentration (BAC) of 0.11% as a toxicological threshold indicating that sufficient alcohol had been consumed to develop a hangover. The cutoff was based on previous research and applied mostly in studies comprising student samples. Previously, we showed that sensitivity to hangovers depends on (estimated) BAC during acute intoxication, with a greater percentage of drinkers reporting hangovers at higher BAC levels. However, a substantial number of participants also reported hangovers at comparatively lower BAC levels. This calls the suitability of the 0.11% threshold into question. Recent research has shown that subjective intoxication, i.e., the level of severity of reported drunkenness, and not BAC, is the most important determinant of hangover severity. Non-student samples often have a much lower alcohol intake compared to student samples, and overall BACs often remain below 0.11%. Despite these lower BACs, many non-student participants report having a hangover, especially when their subjective intoxication levels are high. This may be the case when alcohol consumption on the drinking occasion that results in a hangover significantly exceeds their “normal” drinking level, irrespective of whether they meet the 0.11% threshold in any of these conditions. Whereas consumers may have relative tolerance to the adverse effects at their “regular” drinking level, considerably higher alcohol intake—irrespective of the absolute amount—may consequentially result in a next-day hangover. Taken together, these findings suggest that the 0.11% threshold value as a criterion for having a hangover should be abandoned.

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