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INTRODUCTION & OBJECTIVES: Transperineal prostate biopsy (TPB) has been proposed as a safer more sensitive method for obtaining prostate gland biopsy. Herein we present our technique and report the outcomes and safety profile of TPB utilising our prospective Victorian Transperineal Biopsy Collaboration (VTBC) database. MATERIAL & METHODS: The VTBC is a multi-institutional registry collecting data prospectively from four contributing institutions across Melbourne, Australia. The database is ethics approved at each institution and data collected is based on the minimum dataset published by the Ginsburg Study Group. We present a video of our technique and retrospectively analyse the outcomes of men undergoing TPB. RESULT(S): Our technique for performing TPB, using the Ginsburg protocol, is demonstrated in this video. A total of 1108 men underwent TPB between June 2010 and June 2015, with 894 having adequate histological data for analysis. The indications for TPB were primary biopsy (44.4%), repeat biopsy in the setting of previous negative TRUS biopsy (19%) and confirmatory biopsy for men on active surveillance (36.6%). The mean cohort age was 63.5 (range 41 - 87) and mean pre-biopsy PSA was 9.05 (range 0.14 - 85). In 397 men undergoing TPB as initial biopsy, 328/397(82.6%) were diagnosed with prostate cancer and 215/397 (54.1%) were diagnosed with Gleason >= 7 disease. In 170 men with a prior negative TRUS biopsy, 51/170 (30%) were found to have prostate cancer and 35/170 (20.5%) were diagnosed with Gleason >= 7 disease. Of 327 patients on active surveillance, 137/327 (43%) were upstaged to Gleason >= 7 disease. Overall 230 (25.7%) men were diagnosed with an anterior tumour. The overall rate of acute urinary retention was 3.2%. Only 3(0.3%) patients in the cohort required hospital admission due to biopsy related infection. CONCLUSION(S): The VTBC is the largest reported database of patients having TPB in Australia and New Zealand. The current results show that TPB is

INTRODUCTION & OBJECTIVES: Transperineal prostate biopsy (TPB) has been proposed as a safer more sensitive method for obtaining prostate gland biopsy. Herein we present our technique and report the outcomes and safety profile of TPB utilising our prospective Victorian Transperineal Biopsy Collaboration (VTBC) database. MATERIAL & METHODS: The VTBC is a multi-institutional registry collecting data prospectively from four contributing institutions across Melbourne, Australia. The database is ethics approved at each institution and data collected is based on the minimum dataset published by the Ginsburg Study Group. We present a video of our technique and retrospectively analyse the outcomes of men undergoing TPB. RESULT(S): Our technique for performing TPB, using the Ginsburg protocol, is demonstrated in this video. A total of 1108 men underwent TPB between June 2010 and June 2015, with 894 having adequate histological data for analysis. The indications for TPB were primary biopsy (44.4%), repeat biopsy in the setting of previous negative TRUS biopsy (19%) and confirmatory biopsy for men on active surveillance (36.6%). The mean cohort age was 63.5 (range 41 - 87) and mean pre-biopsy PSA was 9.05 (range 0.14 - 85). In 397 men undergoing TPB as initial biopsy, 328/397(82.6%) were diagnosed with prostate cancer and 215/397 (54.1%) were diagnosed with Gleason >= 7 disease. In 170 men with a prior negative TRUS biopsy, 51/170 (30%) were found to have prostate cancer and 35/170 (20.5%) were diagnosed with Gleason >= 7 disease. Of 327 patients on active surveillance, 137/327 (43%) were upstaged to Gleason >= 7 disease. Overall 230 (25.7%) men were diagnosed with an anterior tumour. The overall rate of acute urinary retention was 3.2%. Only 3(0.3%) patients in the cohort required hospital admission due to biopsy related infection. CONCLUSION(S): The VTBC is the largest reported database of patients having TPB in Australia and New Zealand. The current results show that TPB is