2,625 results on '"Université de Paris"'
Search Results
2. Multiomics insights on the onset, progression, and metastatic evolution of breast cancer
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Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Junta de Castilla y León, Institut National du Cancer (France), Ministerio de Universidades (España), Ligue Nationale contre le Cancer (France), Agence Nationale de la Recherche (France), European Research Council, Fondation pour la Recherche Médicale, Université de Paris, Asociación Española Contra el Cáncer, Universidad de Valladolid, Álvarez-Frutos, Lucía, Barriuso, Daniel, Durán, Mercedes, Infante, Mar, Kroemer, Guido, Palacios-Ramírez, Roberto, Senovilla, Laura, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Junta de Castilla y León, Institut National du Cancer (France), Ministerio de Universidades (España), Ligue Nationale contre le Cancer (France), Agence Nationale de la Recherche (France), European Research Council, Fondation pour la Recherche Médicale, Université de Paris, Asociación Española Contra el Cáncer, Universidad de Valladolid, Álvarez-Frutos, Lucía, Barriuso, Daniel, Durán, Mercedes, Infante, Mar, Kroemer, Guido, Palacios-Ramírez, Roberto, and Senovilla, Laura
- Abstract
Breast cancer is the most common malignant neoplasm in women. Despite progress to date, 700,000 women worldwide died of this disease in 2020. Apparently, the prognostic markers currently used in the clinic are not sufficient to determine the most appropriate treatment. For this reason, great efforts have been made in recent years to identify new molecular biomarkers that will allow more precise and personalized therapeutic decisions in both primary and recurrent breast cancers. These molecular biomarkers include genetic and post-transcriptional alterations, changes in protein expression, as well as metabolic, immunological or microbial changes identified by multiple omics technologies (e.g., genomics, epigenomics, transcriptomics, proteomics, glycomics, metabolomics, lipidomics, immunomics and microbiomics). This review summarizes studies based on omics analysis that have identified new biomarkers for diagnosis, patient stratification, differentiation between stages of tumor development (initiation, progression, and metastasis/recurrence), and their relevance for treatment selection. Furthermore, this review highlights the importance of clinical trials based on multiomics studies and the need to advance in this direction in order to establish personalized therapies and prolong disease-free survival of these patients in the future.
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- 2023
3. 3,4-dimethoxychalcone induces autophagy and reduces neointimal hyperplasia and aortic lesions in mouse models of atherosclerosis
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Institut National du Cancer (France), Agence Nationale de la Recherche (France), Ligue Nationale contre le Cancer (France), Fondation pour la Recherche Médicale, European Research Council, Institut Universitaire de France, Mark Foundation for Cancer Research, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Université de Paris, Cerrato, Giulia, Álvarez-Lucena, Carlota, Sauvat, Allan, Hu, Yanhua, Forveille, Sabrina, Chen, Guo, Durand, Sylvère, Aprahamian, Fanny, Leduc, Marion, Motiño, Omar, Boscá, Lisardo, Xu, Qingbo, Kepp, Oliver, Kroemer, Guido, Institut National du Cancer (France), Agence Nationale de la Recherche (France), Ligue Nationale contre le Cancer (France), Fondation pour la Recherche Médicale, European Research Council, Institut Universitaire de France, Mark Foundation for Cancer Research, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Université de Paris, Cerrato, Giulia, Álvarez-Lucena, Carlota, Sauvat, Allan, Hu, Yanhua, Forveille, Sabrina, Chen, Guo, Durand, Sylvère, Aprahamian, Fanny, Leduc, Marion, Motiño, Omar, Boscá, Lisardo, Xu, Qingbo, Kepp, Oliver, and Kroemer, Guido
- Abstract
Autophagy inducers can prevent cardiovascular aging and age-associated diseases including atherosclerosis. Therefore, we hypothesized that autophagy-inducing compounds that act on atherosclerosis-relevant cells might have a protective role in the development of atherosclerosis. Here we identified 3,4-dimethoxychalcone (3,4-DC) as an inducer of autophagy in several cell lines from endothelial, myocardial and myeloid/macrophagic origin, as demonstrated by the aggregation of the autophagosome marker GFP-LC3 in the cytoplasm of cells, as well as the downregulation of its nuclear pool indicative of autophagic flux. In this respect, 3,4-DC showed a broader autophagy-inducing activity than another chalcone (4,4- dimethoxychalcone), spermidine and triethylene tetramine. Thus, we characterized the potential antiatherogenic activity of 3,4-DC in two different mouse models, namely, (i) neointima formation with smooth muscle expansion of vein segments grafted to the carotid artery and (ii) genetically predisposed ApoE−/− mice fed an atherogenic diet. In the vein graft model, local application of 3,4-DC was able to maintain the lumen of vessels and to reduce neointima lesions. In the diet-induced model, intraperitoneal injections of 3,4-DC significantly reduced the number of atherosclerotic lesions in the aorta. In conclusion, 3,4-DC stands out as an autophagy inducer with potent antiatherogenic activity.
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- 2023
4. Crustal Structure Constraints From the Detection of the SsPp Phase on Mars
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NASA Astrobiology Institute (US), Agence Nationale de la Recherche (France), Centre National D'Etudes Spatiales (France), Université de Paris, Li, J., Beghein, Caroline, Davis, Paul, Wieczorek, Mark A., McLennan, Scott M., Kim, Doyeon, Lekić, Ved, Golombek, Matthew, Schimmel, Martin, Stutzmann, Eléonore, Lognonné, Philippe, NASA Astrobiology Institute (US), Agence Nationale de la Recherche (France), Centre National D'Etudes Spatiales (France), Université de Paris, Li, J., Beghein, Caroline, Davis, Paul, Wieczorek, Mark A., McLennan, Scott M., Kim, Doyeon, Lekić, Ved, Golombek, Matthew, Schimmel, Martin, Stutzmann, Eléonore, and Lognonné, Philippe
- Abstract
The shallowest intracrustal layer (extending to 8 ± 2 km depth) beneath the Mars InSight Lander site exhibits low seismic wave velocity, which is likely related to a combination of high porosity and other lithological factors. The SsPp phase, an SV- to P-wave reflection on the receiver side, is naturally suited for constraining the seismic structure of this top crustal layer since its prominent signal makes it observable with a single station without the need for stacking. We have analyzed six broadband and low-frequency seismic events recorded on Mars and made the first coherent detection of the SsPp phase on the red planet. The timing and amplitude of SsPp confirm the existence of the ∼8 km interface in the crust and the large wave speed (or impedance) contrast across it. With our new constraints from the SsPp phase, we determined that the average P-wave speed in the top crustal layer is between 2.5 and 3.2 km/s, which is a more precise and robust estimate than the previous range of 2.0–3.5 km/s obtained by receiver function analysis. The low velocity of Layer 1 likely results from the presence of relatively low-density lithified sedimentary rocks and/or aqueously altered igneous rocks that also have a significant amount of porosity, possibly as much as 22%–30% by volume (assuming an aspect ratio of 0.1 for the pore space). These porosities and average P-wave speeds are compatible with our current understanding of the upper crustal stratigraphy beneath the InSight Lander site.
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- 2023
5. Shattered Veins Elucidate Brittle Creep Processes in the Deep Slow Slip and Tremor Region
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Université de Paris, ETH Zurich, Muñoz-Montecinos, Jesús, Angiboust, Samuel, García-Casco, Antonio, Raimondo, Tom, Université de Paris, ETH Zurich, Muñoz-Montecinos, Jesús, Angiboust, Samuel, García-Casco, Antonio, and Raimondo, Tom
- Abstract
Deep Slow Slip and Tremors (SSTs) are a combination of transient clusters of tectonic tremors and slow slip associated with extremely elevated fluid pressures. SSTs are thought to reflect a transition from viscous to brittle plate interface rheology and likely exert a first-order control on megathrust seismicity. Nevertheless, the deformation mechanisms governing the source of SSTs remain elusive. We herein document the occurrence of vein networks precipitated and brecciated within the deep SST region under blueschist-facies conditions. These lawsonite-rich vein sets exhibit extensive evidence of brittle deformation and are spatially related to localized, finely milled (cataclastic) shear bands. Petro-geochemical data reveal that brittle deformation was accompanied by the injection of several ultramafic-, mafic- and metasedimentary-derived fluid pulses, imprinting characteristic Cr, high field strength elements, and light over heavy rare earth elements positive anomalies in the vein breccias while leaching light rare earth elements from the cataclastic blueschist host. Our results suggest that metamorphic veins represent zones of mechanical anisotropy within the rock volume prone to localized shearing, brittle deformation and episodic injection of externally derived fluids. These networks demonstrate the importance of former vein sets as structural heterogeneities in triggering fluid-controlled brittle creep events. The combined effects of high pore fluid pressures and rheological heterogeneities in the form of metamorphic veins could trigger the nucleation and propagation of SSTs at the margins of this mechanically anisotropic environment, and thus determine where slip will take place along deep subduction interfaces.
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- 2023
6. Involvement of Bcl-2 Family Proteins in Tetraploidization-Related Senescence
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Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), CSIC-UVA - Instituto de Biología y Genética Molecular (IBGM), Junta de Castilla y León, Ministerio de Universidades (España), Ligue Nationale contre le Cancer (France), Agence Nationale de la Recherche (France), Fondation ARC pour la Recherche sur le Cancer, European Research Council, Fondation pour la Recherche Médicale, Institut National du Cancer (France), Institut Universitaire de France, Université de Paris, Universidad de Valladolid, Barriuso, Daniel, Álvarez-Frutos, Lucía, González-Gutiérrez, Lucía, Motiño, Omar, Kroemer, Guido, Palacios-Ramírez, Roberto, Senovilla, Laura, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), CSIC-UVA - Instituto de Biología y Genética Molecular (IBGM), Junta de Castilla y León, Ministerio de Universidades (España), Ligue Nationale contre le Cancer (France), Agence Nationale de la Recherche (France), Fondation ARC pour la Recherche sur le Cancer, European Research Council, Fondation pour la Recherche Médicale, Institut National du Cancer (France), Institut Universitaire de France, Université de Paris, Universidad de Valladolid, Barriuso, Daniel, Álvarez-Frutos, Lucía, González-Gutiérrez, Lucía, Motiño, Omar, Kroemer, Guido, Palacios-Ramírez, Roberto, and Senovilla, Laura
- Abstract
The B-cell lymphoma 2 (Bcl-2) family of proteins is the main regulator of apoptosis. However, multiple emerging evidence has revealed that Bcl-2 family proteins are also involved in cellular senescence. On the one hand, the different expression of these proteins determines the entry into senescence. On the other hand, entry into senescence modulates the expression of these proteins, generally conferring resistance to apoptosis. With some exceptions, senescent cells are characterized by the upregulation of antiapoptotic proteins and downregulation of proapoptotic proteins. Under physiological conditions, freshly formed tetraploid cells die by apoptosis due to the tetraploidy checkpoint. However, suppression of Bcl-2 associated x protein (Bax), as well as overexpression of Bcl-2, favors the appearance and survival of tetraploid cells. Furthermore, it is noteworthy that our laboratory has shown that the joint absence of Bax and Bcl-2 antagonist/killer (Bak) favors the entry into senescence of tetraploid cells. Certain microtubule inhibitory chemotherapies, such as taxanes and vinca alkaloids, induce the generation of tetraploid cells. Moreover, the combined use of inhibitors of antiapoptotic proteins of the Bcl-2 family with microtubule inhibitors increases their efficacy. In this review, we aim to shed light on the involvement of the Bcl-2 family of proteins in the senescence program activated after tetraploidization and the possibility of using this knowledge to create a new therapeutic strategy targeting cancer cells.
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- 2023
7. Complete genome sequence of Bradyrhizobium sp. strain C-145, a nitrogen-fixing Rhizobacterium used as a peanut inoculant in Argentina
- Author
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Consejo Nacional de Investigaciones Científicas y Técnicas (Argentina), Agencia Nacional de Promoción Científica y Tecnológica (Argentina), Ministerio de Ciencia e Innovación (España), European Commission, Biotechnology and Biological Sciences Research Council (UK), Université de Paris, Institut Pasteur, Nievas, F., Revale, S., Foresto, E., Cossovich, S., Puente, M., Consejo Nacional de Investigaciones Científicas y Técnicas (Argentina), Agencia Nacional de Promoción Científica y Tecnológica (Argentina), Ministerio de Ciencia e Innovación (España), European Commission, Biotechnology and Biological Sciences Research Council (UK), Université de Paris, Institut Pasteur, Nievas, F., Revale, S., Foresto, E., Cossovich, S., and Puente, M.
- Abstract
We present the complete genome sequence of Bradyrhizobium sp. strain C-145, one of the most widely used nitrogen-fixing rhizobacteria for inoculating peanut crops in Argentina. The genome consists of 9.53 Mbp in a single circular chromosome and was determined using a hybrid long- and short-read assembly approach.
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- 2022
8. A truncating variant of RAD51B associated with primary ovarian insufficiency provides insights into its meiotic and somatic functions
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Fundação de Amparo à Pesquisa do Estado de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Junta de Castilla y León, European Commission, Centro de Investigación del Cáncer (España), Université de Paris, Centre National de la Recherche Scientifique (France), Franca, Monica M., Condezo, Yazmine B., Elzaiat, Maëva, Felipe-Medina, Natalia, Sánchez-Sáez, Fernando, Muñoz, Sergio, Sainz-Urruela, Raquel, Martín-Hervás, M. Rosario, García-Valiente, R., Sánchez-Martin, Manuel Adolfo, Astudillo, Aurora, Méndez, Juan, Llano, Elena, Veitia, Reiner A., Mendonca, Berenice B., Pendás, Alberto M., Fundação de Amparo à Pesquisa do Estado de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Junta de Castilla y León, European Commission, Centro de Investigación del Cáncer (España), Université de Paris, Centre National de la Recherche Scientifique (France), Franca, Monica M., Condezo, Yazmine B., Elzaiat, Maëva, Felipe-Medina, Natalia, Sánchez-Sáez, Fernando, Muñoz, Sergio, Sainz-Urruela, Raquel, Martín-Hervás, M. Rosario, García-Valiente, R., Sánchez-Martin, Manuel Adolfo, Astudillo, Aurora, Méndez, Juan, Llano, Elena, Veitia, Reiner A., Mendonca, Berenice B., and Pendás, Alberto M.
- Abstract
Primary ovarian insufficiency (POI) causes female infertility by abolishing normal ovarian function. Although its genetic etiology has been extensively investigated, most POI cases remain unexplained. Using whole-exome sequencing, we identified a homozygous variant in RAD51B –(c.92delT) in two sisters with POI. In vitro studies revealed that this variant leads to translation reinitiation at methionine 64. Here, we show that this is a pathogenic hypomorphic variant in a mouse model. Rad51bc.92delT/c.92delT mice exhibited meiotic DNA repair defects due to RAD51 and HSF2BP/BMRE1 accumulation in the chromosome axes leading to a reduction in the number of crossovers. Interestingly, the interaction of RAD51B-c.92delT with RAD51C and with its newly identified interactors RAD51 and HELQ was abrogated or diminished. Repair of mitomycin-C-induced chromosomal aberrations was impaired in RAD51B/Rad51b-c.92delT human and mouse somatic cells in vitro and in explanted mouse bone marrow cells. Accordingly, Rad51b-c.92delT variant reduced replication fork progression of patient-derived lymphoblastoid cell lines and pluripotent reprogramming efficiency of primary mouse embryonic fibroblasts. Finally, Rad51bc.92delT/c.92delT mice displayed increased incidence of pituitary gland hyperplasia. These results provide new mechanistic insights into the role of RAD51B not only in meiosis but in the maintenance of somatic genome stability.
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- 2022
9. Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming
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Fundación la Caixa, Fundación Científica Asociación Española Contra el Cáncer, Principado de Asturias, European Commission, Instituto de Salud Carlos III, Agence Nationale de la Recherche (France), Ligue Nationale contre le Cancer (France), Association de la Recherche Contre le Cancer (France), Cancéropôle Île-de-France, Chancellerie des Universités de Paris, Fondation pour la Recherche Médicale, European Research Area Network on Cardiovascular Diseases, Institut National du Cancer (France), Fondation Leducq, Université de Paris, Biotechnology and Biological Sciences Research Council (UK), European Research Council, Ministerio de Economía y Competitividad (España), Generalitat de Catalunya, Chondronasiou, Dafni, Gill, Diljeet, Mosteiro, Lluc, Urdinguio, Rocío G., Berenguer-Llergo, Antonio, Aguilera,Mònica, Durand, Sylvère, Aprahamian, Fanny, Nirmalathasan, Nitharsshini, Abad, Maria, Martin-Herranz, Daniel E., Stephan-Otto Attolini, Camille, Prats, Neus, Kroemer, Guido, Fraga, Mario F., Reik, Wolf, Serrano, Manuel, Fundación la Caixa, Fundación Científica Asociación Española Contra el Cáncer, Principado de Asturias, European Commission, Instituto de Salud Carlos III, Agence Nationale de la Recherche (France), Ligue Nationale contre le Cancer (France), Association de la Recherche Contre le Cancer (France), Cancéropôle Île-de-France, Chancellerie des Universités de Paris, Fondation pour la Recherche Médicale, European Research Area Network on Cardiovascular Diseases, Institut National du Cancer (France), Fondation Leducq, Université de Paris, Biotechnology and Biological Sciences Research Council (UK), European Research Council, Ministerio de Economía y Competitividad (España), Generalitat de Catalunya, Chondronasiou, Dafni, Gill, Diljeet, Mosteiro, Lluc, Urdinguio, Rocío G., Berenguer-Llergo, Antonio, Aguilera,Mònica, Durand, Sylvère, Aprahamian, Fanny, Nirmalathasan, Nitharsshini, Abad, Maria, Martin-Herranz, Daniel E., Stephan-Otto Attolini, Camille, Prats, Neus, Kroemer, Guido, Fraga, Mario F., Reik, Wolf, and Serrano, Manuel
- Abstract
The expression of the pluripotency factors OCT4, SOX2, KLF4, and MYC (OSKM) can convert somatic differentiated cells into pluripotent stem cells in a process known as reprogramming. Notably, partial and reversible reprogramming does not change cell identity but can reverse markers of aging in cells, improve the capacity of aged mice to repair tissue injuries, and extend longevity in progeroid mice. However, little is known about the mechanisms involved. Here, we have studied changes in the DNA methylome, transcriptome, and metabolome in naturally aged mice subject to a single period of transient OSKM expression. We found that this is sufficient to reverse DNA methylation changes that occur upon aging in the pancreas, liver, spleen, and blood. Similarly, we observed reversion of transcriptional changes, especially regarding biological processes known to change during aging. Finally, some serum metabolites and biomarkers altered with aging were also restored to young levels upon transient reprogramming. These observations indicate that a single period of OSKM expression can drive epigenetic, transcriptomic, and metabolomic changes toward a younger configuration in multiple tissues and in the serum.
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- 2022
10. A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection
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National Institutes of Health (US), National Center for Advancing Translational Sciences (US), National Human Genome Research Institute (US), Fisher Center for Alzheimer's Research Foundation, Meyer Foundation, Agence Nationale de la Recherche (France), Fondation pour la Recherche Médicale, Pershing Square Foundation, Institut National de la Santé et de la Recherche Médicale (France), Howard Hughes Medical Institute, Rockefeller University, St. Giles Foundation, Université de Paris, European Commission, Hellenic Foundation for Research and Innovation, Science Foundation Ireland, Regione Lazio, Generalitat de Catalunya, National Institute of Allergy and Infectious Diseases (US), Andreakos, Evangelos, Abel, Laurent, Vinh, Donald C., Kaja, Elżbieta, Drolet, Beth A., Zhang, Qian, O’Farrelly, Cliona, Novelli, Giuseppe, Rodríguez-Gallego, Carlos, Haerynck, Filomeen, Prando, Carolina, Pujol, Aurora, COVID Human Genetic Effort, Su, Helen C., Casanova, Jean-Laurent, Spaan, András N., National Institutes of Health (US), National Center for Advancing Translational Sciences (US), National Human Genome Research Institute (US), Fisher Center for Alzheimer's Research Foundation, Meyer Foundation, Agence Nationale de la Recherche (France), Fondation pour la Recherche Médicale, Pershing Square Foundation, Institut National de la Santé et de la Recherche Médicale (France), Howard Hughes Medical Institute, Rockefeller University, St. Giles Foundation, Université de Paris, European Commission, Hellenic Foundation for Research and Innovation, Science Foundation Ireland, Regione Lazio, Generalitat de Catalunya, National Institute of Allergy and Infectious Diseases (US), Andreakos, Evangelos, Abel, Laurent, Vinh, Donald C., Kaja, Elżbieta, Drolet, Beth A., Zhang, Qian, O’Farrelly, Cliona, Novelli, Giuseppe, Rodríguez-Gallego, Carlos, Haerynck, Filomeen, Prando, Carolina, Pujol, Aurora, COVID Human Genetic Effort, Su, Helen C., Casanova, Jean-Laurent, and Spaan, András N.
- Abstract
SARS-CoV-2 infections display tremendous interindividual variability, ranging from asymptomatic infections to life-threatening disease. Inborn errors of, and autoantibodies directed against, type I interferons (IFNs) account for about 20% of critical COVID-19 cases among SARS-CoV-2-infected individuals. By contrast, the genetic and immunological determinants of resistance to infection per se remain unknown. Following the discovery that autosomal recessive deficiency in the DARC chemokine receptor confers resistance to Plasmodium vivax, autosomal recessive deficiencies of chemokine receptor 5 (CCR5) and the enzyme FUT2 were shown to underlie resistance to HIV-1 and noroviruses, respectively. Along the same lines, we propose a strategy for identifying, recruiting, and genetically analyzing individuals who are naturally resistant to SARS-CoV-2 infection.
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- 2022
11. La 'question métisse' au coeur des controverses postcoloniales belges. Eléménts pour une généalogie historiographique et mémorielle
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Etre métis.se dans les Empires (03-04/04/2022: Université de Paris I), Lauro, Amandine, Etre métis.se dans les Empires (03-04/04/2022: Université de Paris I), and Lauro, Amandine
- Abstract
info:eu-repo/semantics/nonPublished
- Published
- 2022
12. The origins of plant reification
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Colloque interdisciplinaire Nos sœurs les plantes: repenser la parentèle (Université de Paris), Hiernaux, Quentin, Colloque interdisciplinaire Nos sœurs les plantes: repenser la parentèle (Université de Paris), and Hiernaux, Quentin
- Abstract
info:eu-repo/semantics/nonPublished
- Published
- 2021
13. Genome-wide and sister chromatid-resolved profiling of protein occupancy in replicated chromatin with ChOR-seq and SCAR-seq
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Independent Research Fund Denmark, European Research Council, Lundbeck Foundation, Novo Nordisk Foundation, Université de Paris, Agence Nationale de la Recherche (France), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Universidad de Sevilla, Petryk, Nataliya, Reverón Gómez, Nazaret, González-Aguilera, Cristina, Dalby, Maria, Andersson, Robin, Groth, Anja, Independent Research Fund Denmark, European Research Council, Lundbeck Foundation, Novo Nordisk Foundation, Université de Paris, Agence Nationale de la Recherche (France), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Universidad de Sevilla, Petryk, Nataliya, Reverón Gómez, Nazaret, González-Aguilera, Cristina, Dalby, Maria, Andersson, Robin, and Groth, Anja
- Abstract
Elucidating the mechanisms underlying chromatin maintenance upon genome replication is critical for the understanding of how gene expression programs and cell identity are preserved across cell divisions. Here, we describe two recently developed techniques, chromatin occupancy after replication (ChOR)-seq and sister chromatids after replication (SCAR)-seq, that profile chromatin occupancy on newly replicated DNA in mammalian cells in 5 d of bench work. Both techniques share a common strategy that includes pulse labeling of newly synthesized DNA and chromatin immunoprecipitation (ChIP), followed by purification and high-throughput sequencing. Whereas ChOR-seq quantitatively profiles the post-replicative abundance of histone modifications and chromatin-associated proteins, SCAR-seq distinguishes chromatin occupancy between nascent sister chromatids. Together, these two complementary techniques have unraveled key mechanisms controlling the inheritance of modified histones during replication and revealed locus-specific dynamics of histone modifications across the cell cycle. Here, we provide the experimental protocols and bioinformatic pipelines for these methods.
- Published
- 2021
14. Multidisciplinary Study of the Impacts of the 1600 CE Huaynaputina Eruption and a Project for Geosites and Geo-touristic Attractions
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Fondo Nacional de Desarrollo Científico y Tecnológico (Chile), Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica (Perú), Université Clermont Auvergne, Institute for Research and Development (Sri Lanka), Université de La Réunion, Université de Paris, Cerema. Climat & Territoires de Demain (France), Gouvernement de la République française, Agence Nationale de la Recherche (France), Mariño, Jersy, Cueva, Kevin, Thouret, Jean-Claude, Arias, Carla, Finizola, Antony, Antoine, Raphael, Delcher, Eric, Fauchard, Cyrille, Donnadieu, Franck, Labazuy, Philippe, Japura, Saida, Gusset, Rachel, Sánchez, Paola, Ramos, Domingo, Macedo, Luisa, Lazarte, Ivonne, Thouret, Liliane, Carpio, José del, Jaime, Lourdes, Saintenoy, Thibault, Fondo Nacional de Desarrollo Científico y Tecnológico (Chile), Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica (Perú), Université Clermont Auvergne, Institute for Research and Development (Sri Lanka), Université de La Réunion, Université de Paris, Cerema. Climat & Territoires de Demain (France), Gouvernement de la République française, Agence Nationale de la Recherche (France), Mariño, Jersy, Cueva, Kevin, Thouret, Jean-Claude, Arias, Carla, Finizola, Antony, Antoine, Raphael, Delcher, Eric, Fauchard, Cyrille, Donnadieu, Franck, Labazuy, Philippe, Japura, Saida, Gusset, Rachel, Sánchez, Paola, Ramos, Domingo, Macedo, Luisa, Lazarte, Ivonne, Thouret, Liliane, Carpio, José del, Jaime, Lourdes, and Saintenoy, Thibault
- Abstract
The Huaynaputina volcano, southern Peru, was the site of the largest historical eruption (VEI 6) in the Andes in 1600 CE, which occurred during the historic transition between the Inca Empire and the Viceroyalty of Peru. This event had severe consequences in the Central Andes and a global climatic impact. Spanish chronicles reported that at least 15 villages or settlements existed around the volcano, of which seven of them were totally destroyed by the eruption. Multidisciplinary studies have allowed us to identify and analyze the characteristics of six settlements buried by the eruption. Tephra fallout and pyroclastic current deposits (PDCs) had different impacts according to the settlement distance from the crater, the location with respect to the emplacement of PDCs along valleys, the geomorphological characteristics of the site, and type of constructions. Thus, Calicanto, Cojraque, and San Juan de Dios, located beneath the main axis of tephra dispersal lobe due west and/or on valley edges, were buried under several meters of pyroclastic deposits, while the villages of Estagagache, Chimpapampa, and Moro Moro, located to the S and SE of the lobe, were partially mantled by tephra. The 1600 CE Huaynaputina eruption created an important geological and cultural heritage, which has scientific, educational, and touristic values. Geo-touristic attractions are proposed based on identification, characterization, and qualitative evaluation of four groups totaling 17 geosites: volcanic geosites, volcanic-cultural geomorphosites, and hot springs. Seven geological roads along with seven viewpoints are proposed, which allow to value the most relevant landscapes, deposits and geological structures.
- Published
- 2021
15. InterEvDock3: A combined template-based and free docking server with increased performance through explicit modeling of complex homologs and integration of covariation-based contact maps
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Agence Nationale de la Recherche (France), Institut Français de Bioinformatique, Université de Paris, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Quignot, Chloé, Postic, Guillaume, Bret, Hélène, Rey, Julien, Granger, Pierre, Murail, Samuel, Chacón, Pablo, Andreani, Jessica, Tuffery, Pierre, Guerois, Raphael, Agence Nationale de la Recherche (France), Institut Français de Bioinformatique, Université de Paris, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Quignot, Chloé, Postic, Guillaume, Bret, Hélène, Rey, Julien, Granger, Pierre, Murail, Samuel, Chacón, Pablo, Andreani, Jessica, Tuffery, Pierre, and Guerois, Raphael
- Abstract
The InterEvDock3 protein docking server exploits the constraints of evolution by multiple means to generate structural models of protein assemblies. The server takes as input either several sequences or 3D structures of proteins known to interact. It returns a set of 10 consensus candidate complexes, together with interface predictions to guide further experimental validation interactively. Three key novelties were implemented in InterEvDock3 to help obtain more reliable models: users can (i) generate template-based structural models of assemblies using close and remote homologs of known 3D structure, detected through an automated search protocol, (ii) select the assembly models most consistent with contact maps from external methods that implement covariation-based contact prediction with or without deep learning and (iii) exploit a novel coevolution-based scoring scheme at atomic level, which leads to significantly higher free docking success rates. The performance of the server was validated on two large free docking benchmark databases, containing respectively 230 unbound targets (Weng dataset) and 812 models of unbound targets (PPI4DOCK dataset). Its effectiveness has also been proven on a number of challenging examples. The InterEvDock3 web interface is available at http://bioserv.rpbs.univ-paris-diderot.fr/services/InterEvDock3/.
- Published
- 2021
16. La radiolittérature :un nouveau champ de recherches littéraires: Présentation de quelques enjeux et écoute commentée d’archives
- Author
-
Listen (séminaire) (29 septembre 2021: Laboratoire de recherches LARCA, Université de Paris / CNRS (en ligne)), Houtart, Manon, Pardo, Céline, Huybrechts, Florence, Listen (séminaire) (29 septembre 2021: Laboratoire de recherches LARCA, Université de Paris / CNRS (en ligne)), Houtart, Manon, Pardo, Céline, and Huybrechts, Florence
- Abstract
info:eu-repo/semantics/nonPublished
- Published
- 2021
17. Analyse sémiologique des personnages dans les récits graphiques: Annexes
- Author
-
Université de Paris, Sähn, Thomas, Université de Paris, and Sähn, Thomas
- Abstract
Annexe de la monographie / Anhang der Monografie: 'Analyse sémiologique des personnages dans les récits graphiques:Tableaux 1–7
- Published
- 2020
18. Analyse sémiologique des personnages dans les récits graphiques: Annexes
- Author
-
Universität Leipzig, Université de Paris, Sähn, Thomas, Universität Leipzig, Université de Paris, and Sähn, Thomas
- Abstract
Annexe de la monographie / Anhang der Monografie: 'Analyse sémiologique des personnages dans les récits graphiques:Tableaux 1–7
- Published
- 2020
19. Analyse sémiologique des personnages dans les récits graphiques: Annexes
- Author
-
Universität Leipzig, Université de Paris, Sähn, Thomas, Universität Leipzig, Université de Paris, and Sähn, Thomas
- Abstract
Annexe de la monographie / Anhang der Monografie: 'Analyse sémiologique des personnages dans les récits graphiques:Tableaux 1–7
- Published
- 2020
20. Analyse sémiologique des personnages dans les récits graphiques: Annexes
- Author
-
Université de Paris, Sähn, Thomas, Université de Paris, and Sähn, Thomas
- Abstract
Annexe de la monographie / Anhang der Monografie: 'Analyse sémiologique des personnages dans les récits graphiques:Tableaux 1–7
- Published
- 2020
21. Les formes du vivant dans la pensée de Whitehead
- Author
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Pour une lecture écologique d'A. N. Whitehead (2020-09-17: Laboratoire Ladyss - Université de Paris), Debaise, Didier, Pour une lecture écologique d'A. N. Whitehead (2020-09-17: Laboratoire Ladyss - Université de Paris), and Debaise, Didier
- Abstract
info:eu-repo/semantics/nonPublished
- Published
- 2020
22. « Jamais deux sans moi », lecture et décryptage d’un conte juridique
- Author
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USL-B - Séminaire interdisciplinaire d'études juridiques (SIEJ), Ost, François, Conférence à l’Ecole doctorale de la Faculté de droit de l’Université de Paris I, USL-B - Séminaire interdisciplinaire d'études juridiques (SIEJ), Ost, François, and Conférence à l’Ecole doctorale de la Faculté de droit de l’Université de Paris I
- Published
- 2019
23. Prendre les histoires au sérieux. Vers une théorie narrative du droit ?
- Author
-
USL-B - Séminaire interdisciplinaire d'études juridiques (SIEJ), Ost, François, conférence dans le cadre du Séminaire interdisciplinaire de cultures juridiques (Université de Paris II), USL-B - Séminaire interdisciplinaire d'études juridiques (SIEJ), Ost, François, and conférence dans le cadre du Séminaire interdisciplinaire de cultures juridiques (Université de Paris II)
- Published
- 2019
24. Quel récit à l’heure de ‘la fin des grands récits’ ?
- Author
-
USL-B - Séminaire interdisciplinaire d'études juridiques (SIEJ), Ost, François, conférence dans le cadre du colloque Les contes et le droit, organisé par la Faculté de droit de l’Université de Paris 1, USL-B - Séminaire interdisciplinaire d'études juridiques (SIEJ), Ost, François, and conférence dans le cadre du colloque Les contes et le droit, organisé par la Faculté de droit de l’Université de Paris 1
- Published
- 2019
25. Croyances masculines et tactiques féminines :l’économie de l’entremise matrimoniale globalisée
- Author
-
Genre et Intimité (Juin 2019: Université de Paris), Sizaire, Laure, Genre et Intimité (Juin 2019: Université de Paris), and Sizaire, Laure
- Abstract
info:eu-repo/semantics/nonPublished
- Published
- 2019
26. Polfre: a time-frequency dependent polarization tool
- Author
-
European Commission, Université de Paris, Ministerio de Ciencia e Innovación (España), Schimmel, Martin [0000-0003-2601-4462], Stutzmann, E. [0000-0002-4348-7475], Schimmel, Martin, Stutzmann, E., European Commission, Université de Paris, Ministerio de Ciencia e Innovación (España), Schimmel, Martin [0000-0003-2601-4462], Stutzmann, E. [0000-0002-4348-7475], Schimmel, Martin, and Stutzmann, E.
- Abstract
This program computes the degree of polarization (DOP) and polarization attributes for continuous three component (3-C) recordings from individual seismic stations employing sliding data windows as function of time & frequency. The employed DOP strategy has been introduced in Schimmel & Gallart (2003) using analytic signal theory in the t-domain. Later, in Schimmel & Gallart (2004), the DOP strategy has been extended to the tf-domain, but using now Eigen theory to compute the polarization attributes. Signals are identified by having a more stable polarization through a frequency dependent time window than noise. Therefore, DOP and polarization attributes are used to detect, analyze and characterize signals which are more polarized than noise. Among others, the approach permits to determine the direction of incoming Rayleigh waves and the determination of polarization spectra. E.g., this code has been used in Schimmel et al. (2011) to characterize microsesimic noise. All figures of this publication are based on the polfre output. Note that most recently, the program has also been employed to analyze ambient noise on Mars (Stutzmann et al., 2021). The program needs the SAC library to read and write data with the SAC binary format. Program descriptions are obtained by executing the codes without any flag. The package further contains Readme-files with information and simple examples to show the workflow. Programs are called through shell scripts or command line and work for Linux/Unix environments. This software was first edited in 2011 and updated in 2019.
- Published
- 2019
27. Matching with Myopic and Farsighted Players
- Author
-
USL-B - Centre de recherche en Economie (CEREC), Mauleon, Ana, Seminar at CES, Université de Paris 1, USL-B - Centre de recherche en Economie (CEREC), Mauleon, Ana, and Seminar at CES, Université de Paris 1
- Published
- 2018
28. Retrieving robust noise-based seismic velocity changes from sparse data sets: synthetic tests and application to Klyuchevskoy volcanic group (Kamchatka)
- Author
-
Repsol, Ministry of Education and Science of the Russian Federation, European Research Council, Science Foundation Ireland, Université de Paris, Gómez-García, Clara [0000-0002-9616-9374], Gómez-García, Clara, Brenguier, F., Boue, P., Shapiro, N. M., Droznin, D. V., Droznina, S. Ya., Senyukov, S. L., Gordeev, E. I., Repsol, Ministry of Education and Science of the Russian Federation, European Research Council, Science Foundation Ireland, Université de Paris, Gómez-García, Clara [0000-0002-9616-9374], Gómez-García, Clara, Brenguier, F., Boue, P., Shapiro, N. M., Droznin, D. V., Droznina, S. Ya., Senyukov, S. L., and Gordeev, E. I.
- Abstract
Continuous noise-based monitoring of seismic velocity changes provides insights into volcanic unrest, earthquake mechanisms and fluid injection in the subsurface. The standard monitoring approach relies on measuring traveltime changes of late coda arrivals between daily and reference noise cross-correlations, usually chosen as stacks of daily cross-correlations. The main assumption of this method is that the shape of the noise correlations does not change over time or, in other terms, that the ambient-noise sources are stationary through time. These conditions are not fulfilled when a strong episodic source of noise, such as a volcanic tremor, for example, perturbs the reconstructed Green's function. In this paper, we propose a general formulation for retrieving continuous time-series of noise-based seismic velocity changes without the requirement of any arbitrary reference cross-correlation function (CCF). Instead, we measure the changes between all possible pairs of daily cross-correlations and invert them using different smoothing parameters to obtain the final velocity change curve. We perform synthetic tests in order to establish a general framework for future applications of this technique. In particular, we study the reliability of velocity change measurements versus the stability of noise CCFs. We apply this approach to a complex data set of noise cross-correlations at Klyuchevskoy volcanic group (Kamchatka), hampered by loss of data and the presence of highly non-stationary seismic tremors.
- Published
- 2018
29. Autophagy in stem cells: repair, remodelling and metabolic reprogramming
- Author
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Ministerio de Economía y Competitividad (España), European Cooperation in Science and Technology, European Commission, Muscular Dystrophy Association (US), Institut National de la Santé et de la Recherche Médicale (France), Centre National de la Recherche Scientifique (France), Université de Paris, Agence Nationale de la Recherche (France), Boya, Patricia, Codogno, Patrice, Rodríguez-Muela, N., Ministerio de Economía y Competitividad (España), European Cooperation in Science and Technology, European Commission, Muscular Dystrophy Association (US), Institut National de la Santé et de la Recherche Médicale (France), Centre National de la Recherche Scientifique (France), Université de Paris, Agence Nationale de la Recherche (France), Boya, Patricia, Codogno, Patrice, and Rodríguez-Muela, N.
- Abstract
Autophagy is a catabolic pathway by which cellular components are delivered to the lysosome for degradation and recycling. Autophagy serves as a crucial intracellular quality control and repair mechanism but is also involved in cell remodelling during development and cell differentiation. In addition, mitophagy, the process by which damaged mitochondria undergo autophagy, has emerged as key regulator of cell metabolism. In recent years, a number of studies have revealed roles for autophagy and mitophagy in the regulation of stem cells, which represent the origin for all tissues during embryonic and postnatal development, and contribute to tissue homeostasis and repair throughout adult life. Here, we review these studies, focussing on the latest evidence that supports the quality control, remodelling and metabolic functions of autophagy during the activation, self-renewal and differentiation of embryonic, adult and cancer stem cells.
- Published
- 2018
30. L'Université Ouverte - Volume 1 : Les enjeux de nos sociétés expliqués à tous
- Author
-
Université de Paris-Dauphine, Université de Paris-Dauphine, Université de Paris-Dauphine, and Université de Paris-Dauphine
- Abstract
L’ascenseur social et la méritocratie sont-ils encore d’actualité dans l’école d’aujourd’hui ? Quels sont les fondements politiques et économiques des délocalisations et relocalisations en France ? Le stress est-il un nouveau mode de management dans les organisations ? Quels sont les enjeux sociaux et économiques de la prise en charge des personnes âgées dépendantes ? Qu’est-ce qui fonde l’attractivité des villes et des agglomérations ? Le pétrole est-il indissociable de l’argent et du pouvoir ? Comment des individus égoïstes peuvent-ils coopérer ? L’agriculture mondiale est-elle prête à relever le défi démographique du XXIe siècle ? Une entreprise peut-elle fonctionner efficacement sans désintéressement ?
- Published
- 2012
31. L'Université Ouverte - Volume 1 : Les enjeux de nos sociétés expliqués à tous
- Author
-
Université de Paris-Dauphine, Université de Paris-Dauphine, Université de Paris-Dauphine, and Université de Paris-Dauphine
- Abstract
L’ascenseur social et la méritocratie sont-ils encore d’actualité dans l’école d’aujourd’hui ? Quels sont les fondements politiques et économiques des délocalisations et relocalisations en France ? Le stress est-il un nouveau mode de management dans les organisations ? Quels sont les enjeux sociaux et économiques de la prise en charge des personnes âgées dépendantes ? Qu’est-ce qui fonde l’attractivité des villes et des agglomérations ? Le pétrole est-il indissociable de l’argent et du pouvoir ? Comment des individus égoïstes peuvent-ils coopérer ? L’agriculture mondiale est-elle prête à relever le défi démographique du XXIe siècle ? Une entreprise peut-elle fonctionner efficacement sans désintéressement ?
- Published
- 2012
32. L'Université Ouverte - Volume 1 : Les enjeux de nos sociétés expliqués à tous
- Author
-
Université de Paris-Dauphine, Université de Paris-Dauphine, Université de Paris-Dauphine, and Université de Paris-Dauphine
- Abstract
L’ascenseur social et la méritocratie sont-ils encore d’actualité dans l’école d’aujourd’hui ? Quels sont les fondements politiques et économiques des délocalisations et relocalisations en France ? Le stress est-il un nouveau mode de management dans les organisations ? Quels sont les enjeux sociaux et économiques de la prise en charge des personnes âgées dépendantes ? Qu’est-ce qui fonde l’attractivité des villes et des agglomérations ? Le pétrole est-il indissociable de l’argent et du pouvoir ? Comment des individus égoïstes peuvent-ils coopérer ? L’agriculture mondiale est-elle prête à relever le défi démographique du XXIe siècle ? Une entreprise peut-elle fonctionner efficacement sans désintéressement ?
- Published
- 2012
33. One-pot aerosol route to MoO3-SiO2-Al2O3 catalysts with ordered super microporosity and high olefin metathesis activity
- Author
-
UCL - SST/IMCN/MOST - Molecules, Solids and Reactivity, Universität Rostock - Leibniz-Institut für Katalyse e.V., Université de Paris 06 - Labo. de la Matière Condensée de Paris, Université de Paris 06 - Labo. dela Matière Condensée de Paris, Debecker, Damien P., Stoyanova, Mariana, Colbeau-Justin , Fréderic, Rodemerck, Uwe, Boissière, Cédric, Gaigneaux, Eric M., Sanchez, Clément, UCL - SST/IMCN/MOST - Molecules, Solids and Reactivity, Universität Rostock - Leibniz-Institut für Katalyse e.V., Université de Paris 06 - Labo. de la Matière Condensée de Paris, Université de Paris 06 - Labo. dela Matière Condensée de Paris, Debecker, Damien P., Stoyanova, Mariana, Colbeau-Justin , Fréderic, Rodemerck, Uwe, Boissière, Cédric, Gaigneaux, Eric M., and Sanchez, Clément
- Abstract
Aerosol processing coupled with surfactant-templated sol–gel synthesis is used to produce MoO3-SiO2-Al2O3 catalysts. By quenching the sol–gel kinetics by fast drying of the aerosol, molecular-scale dispersion of each component is achieved. The structuring agent generates an organized porosity at the nanoscale. The catalysts have a high specific surface area and outstanding olefin metathesis activity.
- Published
- 2012
34. L'Université Ouverte - Volume 1 : Les enjeux de nos sociétés expliqués à tous
- Author
-
Université de Paris-Dauphine, Université de Paris-Dauphine, Université de Paris-Dauphine, and Université de Paris-Dauphine
- Abstract
L’ascenseur social et la méritocratie sont-ils encore d’actualité dans l’école d’aujourd’hui ? Quels sont les fondements politiques et économiques des délocalisations et relocalisations en France ? Le stress est-il un nouveau mode de management dans les organisations ? Quels sont les enjeux sociaux et économiques de la prise en charge des personnes âgées dépendantes ? Qu’est-ce qui fonde l’attractivité des villes et des agglomérations ? Le pétrole est-il indissociable de l’argent et du pouvoir ? Comment des individus égoïstes peuvent-ils coopérer ? L’agriculture mondiale est-elle prête à relever le défi démographique du XXIe siècle ? Une entreprise peut-elle fonctionner efficacement sans désintéressement ?
- Published
- 2012
35. L'Université Ouverte - Volume 1 : Les enjeux de nos sociétés expliqués à tous
- Author
-
Université de Paris-Dauphine, Université de Paris-Dauphine, Université de Paris-Dauphine, and Université de Paris-Dauphine
- Abstract
L’ascenseur social et la méritocratie sont-ils encore d’actualité dans l’école d’aujourd’hui ? Quels sont les fondements politiques et économiques des délocalisations et relocalisations en France ? Le stress est-il un nouveau mode de management dans les organisations ? Quels sont les enjeux sociaux et économiques de la prise en charge des personnes âgées dépendantes ? Qu’est-ce qui fonde l’attractivité des villes et des agglomérations ? Le pétrole est-il indissociable de l’argent et du pouvoir ? Comment des individus égoïstes peuvent-ils coopérer ? L’agriculture mondiale est-elle prête à relever le défi démographique du XXIe siècle ? Une entreprise peut-elle fonctionner efficacement sans désintéressement ?
- Published
- 2012
36. The rise and fall of spatial inequalities in France: a long-run perspective
- Author
-
UCL - SSH/IMMAQ/CORE - Center for operations research and econometrics, GREQAM-Aix Marseille and Paris School of Economics, Paris School of Economics and Université Paris-Sud 11 - ADIS, Université de Paris I-Panthéon-Sorbonne and Université de Paris II-Panthéon-Assas - ERMES, UCL - EUEN/CORE - Center for operations research and econometrics, Combes, Pierre-Philippe, Lafourcade, Miren, Thisse, Jacques-François, Toutain, Jean-Claude, UCL - SSH/IMMAQ/CORE - Center for operations research and econometrics, GREQAM-Aix Marseille and Paris School of Economics, Paris School of Economics and Université Paris-Sud 11 - ADIS, Université de Paris I-Panthéon-Sorbonne and Université de Paris II-Panthéon-Assas - ERMES, UCL - EUEN/CORE - Center for operations research and econometrics, Combes, Pierre-Philippe, Lafourcade, Miren, Thisse, Jacques-François, and Toutain, Jean-Claude
- Abstract
This paper studies the evolution and determinants of spatial inequalities in France. To this end, we use a unique database providing data on value-added, employment, and population over the entire set of French “Départements” in 1860, 1896, 1930, 1982, and 2000. These data cover three sectors: Agriculture, Manufacturing, and Services. Firstly, we confirm the existence of a bell-shaped process of spatial concentration in Manufacturing and Services over time. In contrast, labor productivity has been converging across departments. Secondly, we find considerable agglomeration economies over the whole period. The spatial distribution of these gains is determined mainly by market potential in the first sub-period, 1860–1930, and higher education in the second, 1930–2000.
- Published
- 2010
37. Imperfect mobility of labor across sectors and fiscal transmission
- Author
-
Université de Paris 2 - CRED, Université de Tours - LEO (CNRS UMR 7322), Vrije Universiteit Brussel - Faculteit Economische en Sociale Wetenschappen, Université de Lorraine - BETA, UCL - SSH/IMMAQ/IRES - Institut de recherches économiques et sociales, Cardi, Olivier, Claeys, Peter, Restout, Romain, Université de Paris 2 - CRED, Université de Tours - LEO (CNRS UMR 7322), Vrije Universiteit Brussel - Faculteit Economische en Sociale Wetenschappen, Université de Lorraine - BETA, UCL - SSH/IMMAQ/IRES - Institut de recherches économiques et sociales, Cardi, Olivier, Claeys, Peter, and Restout, Romain
- Abstract
Our paper investigates the impact of government spending shocks on relative sector size and contrasts the effects across countries. Using a panel of sixteen OECD countries over the period 1970-2007, our VAR evidence shows that a rise in government consumption i) increases the share of non tradables in labor and real GDP and lowers the share of tradables, and ii) causes a significant increase in non traded wages relative to traded wages. While the first finding reveals that the non traded sector is more intensive in the government spending shock and experiences a labor inflow that increases its relative size, the second finding suggests the presence of labor mobility costs preventing wage equalization across sectors. Turning to cross-country differences, empirically we detect a positive relationship between the magnitude of the impact responses of sectoral output shares and the degree of labor mobility across sectors. To account for our evidence, we develop an open economy version of the neoclassical model with tradables and non tradables. Our quantitative analysis shows that the model is successful in replicating the responses of sectoral output shares to a fiscal shock, as long as we allow for a difficulty in reallocating labor across sectors along with adjustment costs to capital accumulation. Finally, calibrating the model to country-specific data, we are able to generate a cross-country relationship between the degree of labor mobility and the responses of sectoral output shares which is similar to that in the data.
- Published
- 2017
38. Quantum Rabi model in the Brillouin zone with ultracold atoms
- Author
-
Universidad del País Vasco, Université de Paris, Fundación General CSIC, Comunidad de Madrid, Eusko Jaurlaritza, German Research Foundation, European Commission, Ministerio de Economía y Competitividad (España), Felicetti, Simone, Rico, Enrique, Sabín, Carlos, Ockenfels, Till, Koch, Johannes, Leder, Martin, Gressert, Christopher, Weitz, Martin, Solano, Enrique, Universidad del País Vasco, Université de Paris, Fundación General CSIC, Comunidad de Madrid, Eusko Jaurlaritza, German Research Foundation, European Commission, Ministerio de Economía y Competitividad (España), Felicetti, Simone, Rico, Enrique, Sabín, Carlos, Ockenfels, Till, Koch, Johannes, Leder, Martin, Gressert, Christopher, Weitz, Martin, and Solano, Enrique
- Abstract
The quantum Rabi model describes the interaction between a two-level quantum system and a single bosonic mode. We propose a method to perform a quantum simulation of the quantum Rabi model, introducing an implementation of the two-level system provided by the occupation of Bloch bands in the first Brillouin zone by ultracold atoms in tailored optical lattices. The effective qubit interacts with a quantum harmonic oscillator implemented in an optical dipole trap. Our realistic proposal allows one to experimentally investigate the quantum Rabi model for extreme parameter regimes, which are not achievable with natural light-matter interactions.When the simulated wave function exceeds the validity region of the simulation, we identify a generalized version of the quantum Rabi model in a periodic phase space.
- Published
- 2017
39. Entanglement of superconducting qubits via acceleration radiation
- Author
-
Université de Paris, Comunidad de Madrid, Fundación General CSIC, Ministerio de Economía y Competitividad (España), Eusko Jaurlaritza, García-Álvarez, Laura, Fellicetti, Simone, Rico, Enrique, Solano, Enrique, Sabín, Carlos, Université de Paris, Comunidad de Madrid, Fundación General CSIC, Ministerio de Economía y Competitividad (España), Eusko Jaurlaritza, García-Álvarez, Laura, Fellicetti, Simone, Rico, Enrique, Solano, Enrique, and Sabín, Carlos
- Abstract
We show that simulated relativistic motion can generate entanglement between artificial atoms and protect them from spontaneous emission. We consider a pair of superconducting qubits coupled to a resonator mode, where the modulation of the coupling strength can mimic the harmonic motion of the qubits at relativistic speeds, generating acceleration radiation. We find the optimal feasible conditions for generating a stationary entangled state between the qubits when they are initially prepared in their ground state. Furthermore, we analyse the effects of motion on the probability of spontaneous emission in the standard scenarios of single-atom and two-atom superradiance, where one or two excitations are initially present. Finally, we show that relativistic motion induces sub-radiance and can generate a Zeno-like effect, preserving the excitations from radiative decay.
- Published
- 2017
40. L’orientalisant au cœur de la cité grecque
- Author
-
Séminaire d'archéologie classique de l'Université de Paris I (Panthéon-Sorbonne) (Mars 2007: Université de Paris I (Panthéon-Sorbonne)), Brisart, Thomas, Séminaire d'archéologie classique de l'Université de Paris I (Panthéon-Sorbonne) (Mars 2007: Université de Paris I (Panthéon-Sorbonne)), and Brisart, Thomas
- Abstract
info:eu-repo/semantics/nonPublished
- Published
- 2007
41. L’orientalisant au cœur de la cité grecque
- Author
-
Séminaire d'archéologie classique de l'Université de Paris I (Panthéon-Sorbonne) (Mars 2007: Université de Paris I (Panthéon-Sorbonne)), Brisart, Thomas, Séminaire d'archéologie classique de l'Université de Paris I (Panthéon-Sorbonne) (Mars 2007: Université de Paris I (Panthéon-Sorbonne)), and Brisart, Thomas
- Abstract
info:eu-repo/semantics/nonPublished
- Published
- 2007
42. Principes et méthodes de la découverte interculturelle en FLE
- Author
-
conférence à l'Université de Paris III – Sorbonne Nouvelle (16/12/2003: Université de Paris III – Sorbonne Nouvelle), Louis, Vincent, conférence à l'Université de Paris III – Sorbonne Nouvelle (16/12/2003: Université de Paris III – Sorbonne Nouvelle), and Louis, Vincent
- Abstract
info:eu-repo/semantics/nonPublished
- Published
- 2003
43. Formes céramiques, usages rituels et réseaux de distribution :le calice laconien et la pyxide nikosthénienne
- Author
-
séminaire d'archéologie classique, Université de Paris I Panthéon Sorbonne (2016: Paris), Tsingarida, Athena, séminaire d'archéologie classique, Université de Paris I Panthéon Sorbonne (2016: Paris), and Tsingarida, Athena
- Abstract
info:eu-repo/semantics/nonPublished
- Published
- 2016
44. Surface physics of semiconducting nanowires
- Author
-
Université de Paris, Generalitat de Catalunya, Ministerio de Economía y Competitividad (España), Amato, Michele, Rurali, Riccardo, Université de Paris, Generalitat de Catalunya, Ministerio de Economía y Competitividad (España), Amato, Michele, and Rurali, Riccardo
- Abstract
Semiconducting nanowires (NWs) are firm candidates for novel nanoelectronic devices and a fruitful playground for fundamental physics. Ultra-thin nanowires, with diameters below 10 nm, present exotic quantum effects due to the confinement of the wave functions, e.g. widening of the electronic band-gap, deepening of the dopant states. However, although several reports of sub-10 nm wires exist to date, the most common NWs have diameters that range from 20 to 200 nm, where these quantum effects are absent or play a very minor role. Yet, the research activity on this field is very intense and these materials still promise to provide an important paradigm shift for the design of emerging electronic devices and different kinds of applications. A legitimate question is then: what makes a nanowire different from bulk systems? The answer is certainly the large surface-to-volume ratio. In this article we discuss the most salient features of surface physics and chemistry in group-IV semiconducting nanowires, focusing mostly on Si NWs. First we review the state-of-the-art of NW growth to achieve a smooth and controlled surface morphology. Next we discuss the importance of a proper surface passivation and its role on the NW electronic properties. Finally, stressing the importance of a large surface-to-volume ratio and emphasizing the fact that in a NW the surface is where most of the action takes place, we discuss molecular sensing and molecular doping.
- Published
- 2016
45. Une production sans atelier: Apports de la reconstitution des chaînes opératoires à la caractérisation d'une production
- Author
-
3e Journée d'étude des céramiques antiques (18 novembre 2016: Université de Paris X, Maison Archéologie & Ethnologie, Nanterre), Venant, Nelly, 3e Journée d'étude des céramiques antiques (18 novembre 2016: Université de Paris X, Maison Archéologie & Ethnologie, Nanterre), and Venant, Nelly
- Abstract
info:eu-repo/semantics/nonPublished
- Published
- 2016
46. Les mécanismes de médiations sociales au sein de l’Union européenne
- Author
-
Conférence pour les étudiants de DEA inscrits à l’Institut d’Etudes européennes de l’Université de Paris 8 (15 mars 2001: l’Institut d’Etudes européennes de l’Université de Paris 8), Gobin, Corinne, Conférence pour les étudiants de DEA inscrits à l’Institut d’Etudes européennes de l’Université de Paris 8 (15 mars 2001: l’Institut d’Etudes européennes de l’Université de Paris 8), and Gobin, Corinne
- Abstract
Invitation du professeur Pierre Cours-Salies., info:eu-repo/semantics/nonPublished
- Published
- 2001
47. L’articulation entre l’imaginaire du discours économique et du discours socio-politique au sein de l’Union européenne
- Author
-
Conférence pour les étudiants de DEA inscrits à l’Institut d’Etudes européennes de l’Université de Paris 8 (16 mars 2001: l’Institut d’Etudes européennes de l’Université de Paris 8), Gobin, Corinne, Conférence pour les étudiants de DEA inscrits à l’Institut d’Etudes européennes de l’Université de Paris 8 (16 mars 2001: l’Institut d’Etudes européennes de l’Université de Paris 8), and Gobin, Corinne
- Abstract
Invitation du professeur Bernard Maris, info:eu-repo/semantics/nonPublished
- Published
- 2001
48. L’articulation entre l’imaginaire du discours économique et du discours socio-politique au sein de l’Union européenne
- Author
-
Conférence pour les étudiants de DEA inscrits à l’Institut d’Etudes européennes de l’Université de Paris 8 (16 mars 2001: l’Institut d’Etudes européennes de l’Université de Paris 8), Gobin, Corinne, Conférence pour les étudiants de DEA inscrits à l’Institut d’Etudes européennes de l’Université de Paris 8 (16 mars 2001: l’Institut d’Etudes européennes de l’Université de Paris 8), and Gobin, Corinne
- Abstract
Invitation du professeur Bernard Maris, info:eu-repo/semantics/nonPublished
- Published
- 2001
49. Les mécanismes de médiations sociales au sein de l’Union européenne
- Author
-
Conférence pour les étudiants de DEA inscrits à l’Institut d’Etudes européennes de l’Université de Paris 8 (15 mars 2001: l’Institut d’Etudes européennes de l’Université de Paris 8), Gobin, Corinne, Conférence pour les étudiants de DEA inscrits à l’Institut d’Etudes européennes de l’Université de Paris 8 (15 mars 2001: l’Institut d’Etudes européennes de l’Université de Paris 8), and Gobin, Corinne
- Abstract
Invitation du professeur Pierre Cours-Salies., info:eu-repo/semantics/nonPublished
- Published
- 2001
50. Méthodologie, résultats préliminaires et perspectives du Projet Céramiques & Sociétés
- Author
-
Atelier organisé en collaboration avec l’Université de Paris I, l’UPR 311 du CNRS et l’Université de Paris VI, Jussieu, Institut d’Art et d’Archéologie (11 décembre 1996: Paris), Gosselain, Olivier, Atelier organisé en collaboration avec l’Université de Paris I, l’UPR 311 du CNRS et l’Université de Paris VI, Jussieu, Institut d’Art et d’Archéologie (11 décembre 1996: Paris), and Gosselain, Olivier
- Abstract
info:eu-repo/semantics/nonPublished
- Published
- 1996
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