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1. Phantom limb pain after unilateral arm amputation is associated with decreased heat pain thresholds in the face

Author: Fuchs, Xaver, Diers, Martin, Trojan, Jörg, Kirsch, Pinar, Milde, Christopher, Bekrater-Bodmann, Robin, Rance, Mariela, Foell, Jens, Andoh, Jamila, Becker, Susanne, Flor, Herta, Fuchs, Xaver, Diers, Martin, Trojan, Jörg, Kirsch, Pinar, Milde, Christopher, Bekrater-Bodmann, Robin, Rance, Mariela, Foell, Jens, Andoh, Jamila, Becker, Susanne, and Flor, Herta
Abstract: BACKGROUND The mechanisms underlying chronic phantom limb pain (PLP) are complex and insufficiently understood. Altered sensory thresholds are often associated with chronic pain but quantitative sensory testing (QST) in PLP has so far been inconclusive due to large methodological variation between studies and small sample sizes. METHODS In this study, we applied QST in 37 unilateral upper-limb amputees (23 with and 14 without PLP) and 19 healthy controls. We assessed heat pain (HPT), pressure pain, warmth detection and two-point discrimination thresholds at the residual limb, a homologous point and the thenar of the intact limb as well as both corners of the mouth. RESULTS We did not find significant differences in any of the thresholds between the groups. However, PLP intensity was negatively associated with HPT at all measured body sites except for the residual limb, indicating lower pain thresholds with higher PLP levels. Correlations between HPT and PLP were strongest in the contralateral face (r = -0.65, p < 0.001). Facial HPT were specifically associated with PLP, independent of residual limb pain (RLP) and various other covariates. HPT at the residual limb, however, were significantly associated with RLP, but not with PLP. CONCLUSION We conclude that the association between PLP and, especially facial, HPT could be related to central mechanisms. SIGNIFICANCE Phantom limb pain (PLP) is still poorly understood. We show that PLP intensity is associated with lower heat pain thresholds, especially in the face. This finding could be related to central nervous changes in PLP.
Published: 2022

2. Efficacy and safety of atezolizumab and bevacizumab in the real-world treatment of advanced hepatocellular carcinoma: Experience from four tertiary centers

Author: Himmelsbach, Vera, Pinter, Matthias, Scheiner, Bernhard, Venerito, Marino, Sinner, Friedrich, Zimpel, Carolin, Marquardt, Jens, Trojan, Jörg, Waidmann, Oliver, Finkelmeier, Fabian, Himmelsbach, Vera, Pinter, Matthias, Scheiner, Bernhard, Venerito, Marino, Sinner, Friedrich, Zimpel, Carolin, Marquardt, Jens, Trojan, Jörg, Waidmann, Oliver, and Finkelmeier, Fabian
Abstract: The combination of atezolizumab and bevacizumab (A + B) is the new standard of care for the systemic first-line treatment of hepatocellular carcinoma (HCC). However, up to now there are only few data on the safety and efficacy of A + B in real life. We included patients with advanced HCC treated with A + B as first-line therapy at four cancer centers in Germany and Austria between December 2018 and August 2021. Demographics, overall survival (OS), and adverse events were assessed until 15 September 2021. We included 66 patients. Most patients had compensated cirrhosis (n = 34; 52%), while Child–Pugh class B cirrhosis was observed in 23 patients (35%), and class C cirrhosis in 5 patients (8%). The best responses included a complete response (CR) in 7 patients (11%), a partial response (PR) in 12 patients (18%), stable disease (SD) in 22 patients (33%), and progressive disease in 11 patients (17%). The median progression-free (PFS) survival was 6.5 months, while the median overall survival (OS) was not reached in this cohort (6-month OS: 69%, 12-month OS: 60%, 18-month OS: 58%). Patients with viral hepatitis seemed to have a better prognosis than patients with HCC of non-viral etiology. The real-world PFS and OS were comparable to those of the pivotal IMBRAVE trial, despite including patients with worse liver function in this study. We conclude that A + B is also highly effective in a real-life setting, with manageable toxicity, especially in patients with compensated liver disease. In patients with compromised liver function (Child B and C), the treatment showed low efficacy and, therefore, it should be well considered before administration to these patients.
Published: 2022

3. Low platelet count predicts reduced survival in potentially resectable hepatocellular carcinoma

Author: Schrecker, Christopher, Waidmann, Oliver, Youzouri, Hanan el, Trojan, Jörg, Schnitzbauer, Andreas, Bechstein, Wolf Otto, Zeuzem, Stefan, Koch, Christine, Schrecker, Christopher, Waidmann, Oliver, Youzouri, Hanan el, Trojan, Jörg, Schnitzbauer, Andreas, Bechstein, Wolf Otto, Zeuzem, Stefan, and Koch, Christine
Abstract: The prognostic role of platelet count in hepatocellular carcinoma (HCC) remains unclear, and in fact both thrombocytopenia and thrombocytosis are reported as predictors of unfavourable outcomes. This study aimed to clarify the prognostic value of preoperative platelet count in potentially resectable HCC. We retrospectively reviewed 128 patients who underwent hepatic resection for HCC at a tertiary academic centre (2007–2019). Patient data were modelled by regression analysis, and platelet count was treated as a continuous variable. 89 patients had BCLC 0/A tumours and 39 had BCLC B tumours. Platelet count was higher in patients with larger tumours and lower in patients with higher MELD scores, advanced fibrosis, and portal hypertension (p < 0.001 for all listed variables). After adjusting for BCLC stage and tumour diameter, low platelet count associated with reduced overall survival (hazard ratio 1.25 per 50/nL decrease in platelet count, 95% confidence interval (CI) 1.02–1.53, p = 0.034) and increased perioperative mortality (odds ratio 1.96 per 50/nL decrease in platelet count, 95% CI 1.19–3.53, p = 0.014). Overall, low platelet count correlates with increased liver disease severity, inferior survival, and excess perioperative mortality in resectable HCC. These insights might be applied in clinical practice to better select patients for resection.
Published: 2022

4. Assessing the impact of COVID-19 on liver cancer management (CERO-19)

Author: Muñoz-Martínez, Sergio, Sapena, Victor, Forner, Alejandro, Nault, Jean-Charles, Sapisochin, Gonzalo, Rimassa, Lorenza, Sangro, Bruno, Bruix, Jordi, Sanduzzi-Zamparelli, Marco, Hołówko, Wacław, El Kassas, Mohamed, Mocan, Tudor, Bouattour, Mohamed, Merle, Philippe, Hoogwater, Frederik J.H., Alqahtani, Saleh A., Reeves, Helen L., Pinato, David J., Giorgakis, Emmanouil, Meyer, Tim, Villadsen, Gerda Elisabeth, Wege, Henning, Salati, Massimiliano, Mínguez, Beatriz, Di Costanzo, Giovan Giuseppe, Roderburg, Christoph, Tacke, Frank, Varela, María, Galle, Peter R., Alvares-da-Silva, Mario Reis, Trojan, Jörg, Bridgewater, John, Cabibbo, Giuseppe, Toso, Christian, Lachenmayer, Anja, Casadei-Gardini, Andrea, Toyoda, Hidenori, Lüdde, Tom, Villani, Rosanna, Matilla Peña, Ana María, Guedes Leal, Cassia Regina, Ronzoni, Monica, Delgado, Manuel, Perelló, Christie, Pascual, Sonia, Lledó, José Luis, Argemi, Josepmaria, Basu, Bristi, da Fonseca, Leonardo, Acevedo, Juan, Siebenhüner, Alexander R., Braconi, Chiara, Meyers, Brandon M., Granito, Alessandro, Sala, Margarita, Rodríguez-Lope, Carlos, Blaise, Lorraine, Romero-Gómez, Manuel, Piñero, Federico, Gomez, Dhanny, Mello, Vivianne, Camargo Pinheiro Alves, Rogerio, França, Alex, Branco, Fernanda, Brandi, Giovanni, Pereira, Gustavo, Coll, Susanna, Guarino, María, Benítez, Carlos, Anders, Maria Margarita, Bandi, Juan C., Vergara, Mercedes, Calvo, Mariona, Peck-Radosavljevic, Markus, García-Juárez, Ignacio, Cardinale, Vincenzo, Lozano, Mar, Gambato, Martina, Okolicsanyi, Stefano, Morales- Arraez, Dalia, Elvevi, Alessandra, Muñoz, Alberto E., Lué, Alberto, Iavarone, Massimo, Reig, María, Muñoz-Martínez, Sergio, Sapena, Victor, Forner, Alejandro, Nault, Jean-Charles, Sapisochin, Gonzalo, Rimassa, Lorenza, Sangro, Bruno, Bruix, Jordi, Sanduzzi-Zamparelli, Marco, Hołówko, Wacław, El Kassas, Mohamed, Mocan, Tudor, Bouattour, Mohamed, Merle, Philippe, Hoogwater, Frederik J.H., Alqahtani, Saleh A., Reeves, Helen L., Pinato, David J., Giorgakis, Emmanouil, Meyer, Tim, Villadsen, Gerda Elisabeth, Wege, Henning, Salati, Massimiliano, Mínguez, Beatriz, Di Costanzo, Giovan Giuseppe, Roderburg, Christoph, Tacke, Frank, Varela, María, Galle, Peter R., Alvares-da-Silva, Mario Reis, Trojan, Jörg, Bridgewater, John, Cabibbo, Giuseppe, Toso, Christian, Lachenmayer, Anja, Casadei-Gardini, Andrea, Toyoda, Hidenori, Lüdde, Tom, Villani, Rosanna, Matilla Peña, Ana María, Guedes Leal, Cassia Regina, Ronzoni, Monica, Delgado, Manuel, Perelló, Christie, Pascual, Sonia, Lledó, José Luis, Argemi, Josepmaria, Basu, Bristi, da Fonseca, Leonardo, Acevedo, Juan, Siebenhüner, Alexander R., Braconi, Chiara, Meyers, Brandon M., Granito, Alessandro, Sala, Margarita, Rodríguez-Lope, Carlos, Blaise, Lorraine, Romero-Gómez, Manuel, Piñero, Federico, Gomez, Dhanny, Mello, Vivianne, Camargo Pinheiro Alves, Rogerio, França, Alex, Branco, Fernanda, Brandi, Giovanni, Pereira, Gustavo, Coll, Susanna, Guarino, María, Benítez, Carlos, Anders, Maria Margarita, Bandi, Juan C., Vergara, Mercedes, Calvo, Mariona, Peck-Radosavljevic, Markus, García-Juárez, Ignacio, Cardinale, Vincenzo, Lozano, Mar, Gambato, Martina, Okolicsanyi, Stefano, Morales- Arraez, Dalia, Elvevi, Alessandra, Muñoz, Alberto E., Lué, Alberto, Iavarone, Massimo, and Reig, María
Abstract: [Background & Aims] The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems and it may have heavily impacted patients with liver cancer (LC). Herein, we evaluated whether the schedule of LC screening or procedures has been interrupted or delayed because of the COVID-19 pandemic., [Methods] An international survey evaluated the impact of the COVID-19 pandemic on clinical practice and clinical trials from March 2020 to June 2020, as the first phase of a multicentre, international, and observational project. The focus was on patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma, cared for around the world during the first COVID-19 pandemic wave., [Results] Ninety-one centres expressed interest to participate and 76 were included in the analysis, from Europe, South America, North America, Asia, and Africa (73.7%, 17.1%, 5.3%, 2.6%, and 1.3% per continent, respectively). Eighty-seven percent of the centres modified their clinical practice: 40.8% the diagnostic procedures, 80.9% the screening programme, 50% cancelled curative and/or palliative treatments for LC, and 41.7% modified the liver transplantation programme. Forty-five out of 69 (65.2%) centres in which clinical trials were running modified their treatments in that setting, but 58.1% were able to recruit new patients. The phone call service was modified in 51.4% of centres which had this service before the COVID-19 pandemic (n = 19/37)., [Conclusions] The first wave of the COVID-19 pandemic had a tremendous impact on the routine care of patients with liver cancer. Modifications in screening, diagnostic, and treatment algorithms may have significantly impaired the outcome of patients. Ongoing data collection and future analyses will report the benefits and disadvantages of the strategies implemented, aiding future decision-making., [Lay summary] The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems globally. Herein, we assessed the impact of the first wave pandemic on patients with liver cancer and found that routine care for these patients has been majorly disrupted, which could have a significant impact on outcomes.
Published: 2021

5. Complete Pathological Response After Neoadjuvant Short-Course Immunotherapy with Ipilimumab and Nivolumab in Locally Advanced MSI-H/dMMR Rectal Cancer

Author: Trojan, Jörg, Stintzing, Sebastian, Haase, Oliver, Koch, Christine, Ziegler, Paul, Demes, Melanie Christin, Jelas, Ivan, Trojan, Jörg, Stintzing, Sebastian, Haase, Oliver, Koch, Christine, Ziegler, Paul, Demes, Melanie Christin, and Jelas, Ivan
Abstract: Background: Patients with colorectal carcinoma and high-grade microsatellite instability (MSI-H) or deficiency in mismatch repair (dMMR) exceptionally respond to immune checkpoint inhibitors (ICIs). ICIs are more active in treatment-naïve patients than in patients with refractory MSI-H/dMMR metastatic colorectal cancer and even more active in patients with locally advanced tumors. Material and Methods: A 33-year-old male patient with Lynch syndrome was diagnosed with a locally advanced rectal cancer and refused standard neoadjuvant chemoradiation because of the potential harm of sexual dysfunction. MMR and microsatellite instability status were analyzed by immunohistochemistry and fragment length polymerase chain reaction followed by capillary electrophoresis. Results: After MSI-H/dMMR was confirmed, the patient was treated with ICIs (1 mg/kg ipilimumab at day 1 and 3 mg/kg nivolumab at day 1 and 15). A complete clinical response was documented at day 21 after start of treatment. The patient underwent a total mesorectal excision at day 30. In the extirpated tissue, a complete pathological response was confirmed. Conclusion: In MSI-H/dMMR locally advanced rectal cancer short-course ICI treatment is highly effective and may be discussed in patients with dMMR locally advanced rectal cancer.
Published: 2021

6. Complete pathological response after neoadjuvant short-course immunotherapy with Ipilimumab and Nivolumab in locally advanced MSI-H/dMMR rectal cancer

Author: Trojan, Jörg, Stintzing, Sebastian Jörg, Haase, Oliver, Koch, Christine, Ziegler, Paul, Demes, Melanie Christin, Jelas, Ivan, Trojan, Jörg, Stintzing, Sebastian Jörg, Haase, Oliver, Koch, Christine, Ziegler, Paul, Demes, Melanie Christin, and Jelas, Ivan
Abstract: Background: Patients with colorectal carcinoma and high-grade microsatellite instability (MSI-H) or deficiency in mismatch repair (dMMR) exceptionally respond to immune checkpoint inhibitors (ICIs). ICIs are more active in treatment-naïve patients than in patients with refractory MSI-H/dMMR metastatic colorectal cancer and even more active in patients with locally advanced tumors. Material and Methods: A 33-year-old male patient with Lynch syndrome was diagnosed with a locally advanced rectal cancer and refused standard neoadjuvant chemoradiation because of the potential harm of sexual dysfunction. MMR and microsatellite instability status were analyzed by immunohistochemistry and fragment length polymerase chain reaction followed by capillary electrophoresis. Results: After MSI-H/dMMR was confirmed, the patient was treated with ICIs (1 mg/kg ipilimumab at day 1 and 3 mg/kg nivolumab at day 1 and 15). A complete clinical response was documented at day 21 after start of treatment. The patient underwent a total mesorectal excision at day 30. In the extirpated tissue, a complete pathological response was confirmed. Conclusion: In MSI-H/dMMR locally advanced rectal cancer short-course ICI treatment is highly effective and may be discussed in patients with dMMR locally advanced rectal cancer.
Published: 2021

7. Comparative efficacy of cabozantinib and ramucirumab after sorafenib for patients with hepatocellular carcinoma and alpha-fetoprotein ≥ 400 ng/ml : a matching-adjusted indirect comparison

Author: Trojan, Jörg, Mollon, Patrick, Daniele, Bruno, Marteau, Florence, Martín, Lidia, Li, Yuxin, Xu, Qing, Piscaglia, Fabio, Zaucha, Renata, Sarker, Debashis, Lim, Ho Yeong, Venerito, Marino, Trojan, Jörg, Mollon, Patrick, Daniele, Bruno, Marteau, Florence, Martín, Lidia, Li, Yuxin, Xu, Qing, Piscaglia, Fabio, Zaucha, Renata, Sarker, Debashis, Lim, Ho Yeong, and Venerito, Marino
Abstract: Individual patient data (IPD) from the CELESTIAL trial (cabozantinib) and population-level data from the REACH-2 trial (ramucirumab) were used. To align with REACH-2, the CELESTIAL population was limited to patients who received first-line sorafenib only and had baseline serum AFP ≥ 400 ng/mL. The IPD from CELESTIAL were weighted to balance the distribution of 11 effect-modifying baseline characteristics with those of REACH-2. Overall survival (OS; primary endpoint) and progression-free survival (PFS) were compared for the CELESTIAL (matching-adjusted) and REACH-2 populations using weighted Kaplan-Meier (KM) curves and parametric (OS, Weibull; PFS, log-logistic) modeling. Rates of treatment-related adverse events (TRAEs) and TRAE-related discontinuations were also compared.
Published: 2021

8. Combination of sorafenib and transarterial chemoembolization in selected patients with advanced-stage hepatocellular carcinoma: a retrospective cohort study at three german liver centers

Author: Koch, Christine, Göller, Markus, Schott, Eckart, Waidmann, Oliver, Winkel, Mark op den, Paprottka, Philipp Marius, Zangos, Stephan, Vogel, Thomas, Bechstein, Wolf Otto, Zeuzem, Stefan, Kolligs, Frank Thomas, Trojan, Jörg, Koch, Christine, Göller, Markus, Schott, Eckart, Waidmann, Oliver, Winkel, Mark op den, Paprottka, Philipp Marius, Zangos, Stephan, Vogel, Thomas, Bechstein, Wolf Otto, Zeuzem, Stefan, Kolligs, Frank Thomas, and Trojan, Jörg
Abstract: Background and Aims. Systemic treatment with sorafenib has been the standard of care (SOC) in patients with advanced Barcelona Clinic Liver Cancer (BCLC) stage C hepatocellular carcinoma (HCC) for more than a decade. TACE has been reported to allow better local tumor control in selected patients with BCLC stage C HCC. Methods. A retrospective analysis of patients with BCLC stage C HCC that were treated with sorafenib and TACE was conducted; they were compared to BCLC stage C patients treated either with TACE or sorafenib in the same period of time outside a clinical trial. Results. A total of 201 patients with BCLC stage C were identified, who were treated with either sorafenib and TACE (group A; n = 54), sorafenib (group B; n = 82) or TACE (group C; n = 65). No significant difference in baseline characteristics was observed. Time to progression was 7.0 months (95% CI: 4.3–9.7), 4.1 months (95% CI: 3.6–4.7) and 5.0 months (95% CI: 2.9–7.1) in groups A, B and C, respectively, and overall survival was 16.5 months (95% CI: 15.0–18.1), 8.4 months (95% CI: 6.0–10.8) and 10.5 months (95% CI: 7.5–13.6), respectively (group A vs. group B: p < 0.001; group A vs. group C: p = 0.0023). Adverse events of grade 3/4 occurred in 34% of patients in group A. Conclusions. Although sorafenib is a SOC in patients with BCLC stage C HCC, TACE is frequently used as an additional locoregional treatment in selected patients. This combined approach resulted in a significant overall survival benefit in selected patients, although randomized trials have not yet proven this benefit.
Published: 2021

9. Publisher Correction: The Scales Project, a cross-national dataset on the interpretation of thermal perception scales.

Author: Schweiker, Marcel, Schweiker, Marcel, Abdul-Zahra, Amar, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha, Azadeh, Montazami, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon-Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti, Daniel, Lyrian, Vecchi, Renata, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla, Harimi, Djamila, Hellwig, Runa, Huebner, Gesche, Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, McGill, Gráinne, Mino-Rodriguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph, Rivera, Ma, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu, Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, Zomorodian, Zahra, Schweiker, Marcel, Schweiker, Marcel, Abdul-Zahra, Amar, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha, Azadeh, Montazami, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon-Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti, Daniel, Lyrian, Vecchi, Renata, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla, Harimi, Djamila, Hellwig, Runa, Huebner, Gesche, Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, McGill, Gráinne, Mino-Rodriguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph, Rivera, Ma, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu, Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, and Zomorodian, Zahra
Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Published: 2020

10. Evaluating assumptions of scales for subjective assessment of thermal environments – Do laypersons perceive them the way, we researchers believe?

Author: Schweiker, Marcel, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azar, Elie, Bannazadeh, Bahareh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M., Jin, Quan, Jowkar, Mina, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M. C.Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, Mino-Rodriguez, Isabel, Montazami, Azadeh, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Lígia, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, Ma Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, Zomorodian, Zahra Sadat, Schweiker, Marcel, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azar, Elie, Bannazadeh, Bahareh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M., Jin, Quan, Jowkar, Mina, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M. C.Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, Mino-Rodriguez, Isabel, Montazami, Azadeh, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Lígia, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, Ma Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, and Zomorodian, Zahra Sadat
Abstract: People's subjective response to any thermal environment is commonly investigated by using rating scales describing the degree of thermal sensation, comfort, and acceptability. Subsequent analyses of results collected in this way rely on the assumption that specific distances between verbal anchors placed on the scale exist and that relationships between verbal anchors from different dimensions that are assessed (e.g. thermal sensation and comfort) do not change. Another inherent assumption is that such scales are independent of the context in which they are used (climate zone, season, etc.). Despite their use worldwide, there is indication that contextual differences influence the way the scales are perceived and therefore question the reliability of the scales’ interpretation. To address this issue, a large international collaborative questionnaire study was conducted in 26 countries, using 21 different languages, which led to a dataset of 8225 questionnaires. Results, analysed by means of robust statistical techniques, revealed that only a subset of the responses are in accordance with the mentioned assumptions. Significant differences appeared between groups of participants in their perception of the scales, both in relation to distances of the anchors and relationships between scales. It was also found that respondents’ interpretations of scales changed with contextual factors, such as climate, season, and language. These findings highlight the need to carefully consider context-dependent factors in interpreting and reporting results from thermal comfort studies or post-occupancy evaluations, as well as to revisit the use of rating scales and the analysis methods used in thermal comfort studies to improve their reliability.
Published: 2020

11. Publisher Correction: The Scales Project, a cross-national dataset on the interpretation of thermal perception scales.

Author: Schweiker, Marcel, Schweiker, Marcel, Abdul-Zahra, Amar, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azadeh, Montazami, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon-Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, Vecchi, Renata De, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T, Huebner, Gesche M, Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, MC Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, McGill, Gráinne, Mino-Rodriguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Ligia, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F, Rivera, Ma Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B, Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, Zomorodian, Zahra Sadat, Schweiker, Marcel, Schweiker, Marcel, Abdul-Zahra, Amar, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azadeh, Montazami, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon-Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, Vecchi, Renata De, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T, Huebner, Gesche M, Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, MC Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, McGill, Gráinne, Mino-Rodriguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Ligia, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F, Rivera, Ma Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B, Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, and Zomorodian, Zahra Sadat
Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Published: 2020

12. Evaluating assumptions of scales for subjective assessment of thermal environments – Do laypersons perceive them the way, we researchers believe?

Author: Universidad de Sevilla. Departamento de Construcciones Arquitectónicas I (ETSA), Universidad de Sevilla. TEP130: Arquitectura, Patrimonio y Sostenibilidad: Acústica, Iluminación, Óptica y Energía, Schweiker, Marcel, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azar, Elie, Bannazadeh, Bahareh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera Escudero, Jessica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M., Jin, Quan, Jowkar, Mina, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M. C. Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, Mino Rodríguez, Isabel, Montazami, Azadeh, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Lígia, Pérez Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, María Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, Zomorodian, Zahra Sadat, Universidad de Sevilla. Departamento de Construcciones Arquitectónicas I (ETSA), Universidad de Sevilla. TEP130: Arquitectura, Patrimonio y Sostenibilidad: Acústica, Iluminación, Óptica y Energía, Schweiker, Marcel, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azar, Elie, Bannazadeh, Bahareh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera Escudero, Jessica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M., Jin, Quan, Jowkar, Mina, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M. C. Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, Mino Rodríguez, Isabel, Montazami, Azadeh, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Lígia, Pérez Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, María Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, and Zomorodian, Zahra Sadat
Abstract: People's subjective response to any thermal environment is commonly investigated by using rating scales describing the degree of thermal sensation, comfort, and acceptability. Subsequent analyses of results collected in this way rely on the assumption that specific distances between verbal anchors placed on the scale exist and that relationships between verbal anchors from different dimensions that are assessed (e.g. thermal sensation and comfort) do not change. Another inherent assumption is that such scales are independent of the context in which they are used (climate zone, season, etc.). Despite their use worldwide, there is indication that contextual differences influence the way the scales are perceived and therefore question the reliability of the scales’ interpretation. To address this issue, a large international collaborative questionnaire study was conducted in 26 countries, using 21 different languages, which led to a dataset of 8225 questionnaires. Results, analysed by means of robust statistical techniques, revealed that only a subset of the responses are in accordance with the mentioned assumptions. Significant differences appeared between groups of participants in their perception of the scales, both in relation to distances of the anchors and relationships between scales. It was also found that respondents’ interpretations of scales changed with contextual factors, such as climate, season, and language. These findings highlight the need to carefully consider context-dependent factors in interpreting and reporting results from thermal comfort studies or post-occupancy evaluations, as well as to revisit the use of rating scales and the analysis methods used in thermal comfort studies to improve their reliability.
Published: 2020

13. Evaluating assumptions of scales for subjective assessment of thermal environments – Do laypersons perceive them the way, we researchers believe?

Author: Universidad de Sevilla. Departamento de Construcciones Arquitectónicas I (ETSA), Universidad de Sevilla. TEP130: Arquitectura, Patrimonio y Sostenibilidad: Acústica, Iluminación, Óptica y Energía, Schweiker, Marcel, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azar, Elie, Bannazadeh, Bahareh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera Escudero, Jessica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M., Jin, Quan, Jowkar, Mina, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M. C. Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, Mino Rodríguez, Isabel, Montazami, Azadeh, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Lígia, Pérez Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, María Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, Zomorodian, Zahra Sadat, Universidad de Sevilla. Departamento de Construcciones Arquitectónicas I (ETSA), Universidad de Sevilla. TEP130: Arquitectura, Patrimonio y Sostenibilidad: Acústica, Iluminación, Óptica y Energía, Schweiker, Marcel, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azar, Elie, Bannazadeh, Bahareh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera Escudero, Jessica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M., Jin, Quan, Jowkar, Mina, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M. C. Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, Mino Rodríguez, Isabel, Montazami, Azadeh, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Lígia, Pérez Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, María Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, and Zomorodian, Zahra Sadat
Abstract: People's subjective response to any thermal environment is commonly investigated by using rating scales describing the degree of thermal sensation, comfort, and acceptability. Subsequent analyses of results collected in this way rely on the assumption that specific distances between verbal anchors placed on the scale exist and that relationships between verbal anchors from different dimensions that are assessed (e.g. thermal sensation and comfort) do not change. Another inherent assumption is that such scales are independent of the context in which they are used (climate zone, season, etc.). Despite their use worldwide, there is indication that contextual differences influence the way the scales are perceived and therefore question the reliability of the scales’ interpretation. To address this issue, a large international collaborative questionnaire study was conducted in 26 countries, using 21 different languages, which led to a dataset of 8225 questionnaires. Results, analysed by means of robust statistical techniques, revealed that only a subset of the responses are in accordance with the mentioned assumptions. Significant differences appeared between groups of participants in their perception of the scales, both in relation to distances of the anchors and relationships between scales. It was also found that respondents’ interpretations of scales changed with contextual factors, such as climate, season, and language. These findings highlight the need to carefully consider context-dependent factors in interpreting and reporting results from thermal comfort studies or post-occupancy evaluations, as well as to revisit the use of rating scales and the analysis methods used in thermal comfort studies to improve their reliability.
Published: 2020

14. Publisher Correction:The Scales Project, a cross-national dataset on the interpretation of thermal perception scales

Author: Universidad de Sevilla. Departamento de Construcciones Arquitectónicas I (ETSA), Universidad de Sevilla. TEP130: Arquitectura, Patrimonio y Sostenibilidad: Acústica, Iluminación, Óptica y Energía, Schweiker, Marcel, Abdul-Zahra, Amar, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azadeh, Montazami, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera Escudero, Jessica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M., Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M. C.Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, McGill, Gráinne, Mino Rodríguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Lígia, Pérez Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, María Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, Zomorodian, Zahra Sadat, Universidad de Sevilla. Departamento de Construcciones Arquitectónicas I (ETSA), Universidad de Sevilla. TEP130: Arquitectura, Patrimonio y Sostenibilidad: Acústica, Iluminación, Óptica y Energía, Schweiker, Marcel, Abdul-Zahra, Amar, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azadeh, Montazami, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera Escudero, Jessica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M., Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M. C.Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, McGill, Gráinne, Mino Rodríguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Lígia, Pérez Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, María Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, and Zomorodian, Zahra Sadat
Published: 2020

15. Evaluating assumptions of scales for subjective assessment of thermal environments – Do laypersons perceive them the way, we researchers believe?

Author: Universidad de Sevilla. Departamento de Construcciones Arquitectónicas I (ETSA), Universidad de Sevilla. TEP130: Arquitectura, Patrimonio y Sostenibilidad: Acústica, Iluminación, Óptica y Energía, Schweiker, Marcel, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azar, Elie, Bannazadeh, Bahareh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jessica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M., Jin, Quan, Jowkar, Mina, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M. C. Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, Mino Rodríguez, Isabel, Montazami, Azadeh, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Lígia, Pérez Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, María Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, Zomorodian, Zahra Sadat, Universidad de Sevilla. Departamento de Construcciones Arquitectónicas I (ETSA), Universidad de Sevilla. TEP130: Arquitectura, Patrimonio y Sostenibilidad: Acústica, Iluminación, Óptica y Energía, Schweiker, Marcel, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azar, Elie, Bannazadeh, Bahareh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jessica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M., Jin, Quan, Jowkar, Mina, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M. C. Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, Mino Rodríguez, Isabel, Montazami, Azadeh, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Lígia, Pérez Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, María Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, and Zomorodian, Zahra Sadat
Abstract: People's subjective response to any thermal environment is commonly investigated by using rating scales describing the degree of thermal sensation, comfort, and acceptability. Subsequent analyses of results collected in this way rely on the assumption that specific distances between verbal anchors placed on the scale exist and that relationships between verbal anchors from different dimensions that are assessed (e.g. thermal sensation and comfort) do not change. Another inherent assumption is that such scales are independent of the context in which they are used (climate zone, season, etc.). Despite their use worldwide, there is indication that contextual differences influence the way the scales are perceived and therefore question the reliability of the scales’ interpretation. To address this issue, a large international collaborative questionnaire study was conducted in 26 countries, using 21 different languages, which led to a dataset of 8225 questionnaires. Results, analysed by means of robust statistical techniques, revealed that only a subset of the responses are in accordance with the mentioned assumptions. Significant differences appeared between groups of participants in their perception of the scales, both in relation to distances of the anchors and relationships between scales. It was also found that respondents’ interpretations of scales changed with contextual factors, such as climate, season, and language. These findings highlight the need to carefully consider context-dependent factors in interpreting and reporting results from thermal comfort studies or post-occupancy evaluations, as well as to revisit the use of rating scales and the analysis methods used in thermal comfort studies to improve their reliability.
Published: 2020

16. Publisher Correction:The Scales Project, a cross-national dataset on the interpretation of thermal perception scales

Author: Universidad de Sevilla. Departamento de Construcciones Arquitectónicas I (ETSA), Universidad de Sevilla. TEP130: Arquitectura, Patrimonio y Sostenibilidad: Acústica, Iluminación, Óptica y Energía, Schweiker, Marcel, Abdul-Zahra, Amar, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azadeh, Montazami, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera Escudero, Jessica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M., Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M. C.Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, McGill, Gráinne, Mino Rodríguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Lígia, Pérez Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, María Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, Zomorodian, Zahra Sadat, Universidad de Sevilla. Departamento de Construcciones Arquitectónicas I (ETSA), Universidad de Sevilla. TEP130: Arquitectura, Patrimonio y Sostenibilidad: Acústica, Iluminación, Óptica y Energía, Schweiker, Marcel, Abdul-Zahra, Amar, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azadeh, Montazami, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera Escudero, Jessica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M., Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M. C.Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, McGill, Gráinne, Mino Rodríguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Lígia, Pérez Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, María Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, and Zomorodian, Zahra Sadat
Published: 2020

17. Cetuximab-mediated protection from hypoxia-induced cell death: implications for therapy sequence in colorectal cancer

Author: Urban, Hans, Maurer, Gabriele D., Luger, Anna-Luisa, Lorenz, Nadja Irene, Sauer, Benedikt, Stroh, Christopher, Trojan, Jörg, Mittelbronn, Michel Guy André, Steinbach, Joachim Peter, Harter, Patrick Nikolaus, Ronellenfitsch, Michael Wilfried, Urban, Hans, Maurer, Gabriele D., Luger, Anna-Luisa, Lorenz, Nadja Irene, Sauer, Benedikt, Stroh, Christopher, Trojan, Jörg, Mittelbronn, Michel Guy André, Steinbach, Joachim Peter, Harter, Patrick Nikolaus, and Ronellenfitsch, Michael Wilfried
Abstract: Simple Summary: Therapeutic antibodies are an integral part of treatment regimens for metastasized colorectal cancer. In KRAS wildtype tumors both bevacizumab and cetuximab are active. While bevacizumab has previously been shown to induce tumor hypoxia, we here report that EGFR inhibition by cetuximab protects colon cancer cells from hypoxia-induced cell death. This effect appears to be responsible for the inferior efficacy of a treatment sequence of bevacizumab followed by cetuximab versus an inverse sequence that we observed in a colorectal cancer mouse model. It also offers a mechanistic explanation for effects observed in clinical trials such as underadditive or even detrimental effects when combining bevacizumab and cetuximab (CAIRO2 trial) and the superior efficacy of first line cetuximab (FIRE-3 trial) under chemotherapy backbones in colorectal cancer. Abstract: Monoclonal antibodies like cetuximab, targeting the epidermal growth factor receptor (EGFR), and bevacizumab, targeting the vascular endothelial growth factor (VEGF), are an integral part of treatment regimens for metastasized colorectal cancer. However, inhibition of the EGFR has been shown to protect human glioma cells from cell death under hypoxic conditions. In colon carcinoma cells, the consequences of EGFR blockade in hypoxia (e.g., induced by bevacizumab) have not been evaluated yet. LIM1215 and SW948 colon carcinoma and LNT-229 glioblastoma cells were treated with cetuximab, PD153035, and erlotinib and analyzed for cell density and viability. The sequential administration of either cetuximab followed by bevacizumab (CET->BEV) or bevacizumab followed by cetuximab (BEV->CET) was investigated in a LIM1215 (KRAS wildtype) and SW948 (KRAS mutant) xenograft mouse model. In vitro, cetuximab protected from hypoxia. In the LIM1215 model, a survival benefit with cetuximab and bevacizumab monotherapy was observed, but only the sequence CET->BEV showed an additional benefit. This effect was confirmed in t
Published: 2020

18. Photochemical internalization and gemcitabine combined with first-line chemotherapy in perihilar cholangiocarcinoma: observations in three patients

Author: Dechêne, Alexander, Kasper, Stefan, Olivecrona, Hans, Schirra, Jörg, Trojan, Jörg, Dechêne, Alexander, Kasper, Stefan, Olivecrona, Hans, Schirra, Jörg, and Trojan, Jörg
Abstract: Photochemical internalization (PCI) is a technology to induce a localized, intracellular enhancement of therapeutics that are processed through endosomal pathways, including gemcitabine in malignant cells. In addition to a direct phototoxic and tumoricidal effect, PCI specifically disrupts endosomal membranes and, thereby, the compartmentalization of certain cytotoxic compounds to enhance a drug’s intended intracellular target reach within the tissue treated. Non-resectable extrahepatic cholangiocarcinoma (eCCA) is a common primary tumor and gemcitabine/cisplatin chemotherapy is widely considered standard of care for it. PCI is well suited as an endoscopic intervention, and clinical observations in three subjects participating in a phase I/IIa dose escalation safety trial are described. The trial included patients with perihilar, non-resectable CCA suitable for standard-of-care chemotherapy. Per protocol, a single endoscopic PCI procedure with gemcitabine was conducted at the initiation of standard gemcitabine/cisplatin therapy. Sixteen patients enrolled in the initial dose escalation phase of the trial, which later was extended to explore the safety of a second PCI procedure during chemotherapy. While limited to a case series, the various clinical observations described here serve to illustrate the effects of localized, perihilar tumor targeting in appropriate patients by any safe methodology, including PCI. As previously indicated by clinical data using other localized treatment modalities, adding a directed, tumor-targeting treatment to systemic therapy to ameliorate the progressively expanding extrahepatic tumor burden can have important effects on the overall outcome of systemic treatment in many patients who have incurable eCCA.
Published: 2020

19. AFP ratio predicts HCC recurrence after liver transplantation

Author: Alpini, Gianfranco, Koch, Christine, Bette, Theresa, Waidmann, Oliver, Filmann, Natalie, Schrecker, Christopher, Trojan, Jörg, Weiler, Nina, Vermehren, Johannes, Schnitzbauer, Andreas, Bechstein, Wolf Otto, Zeuzem, Stefan, Herrmann, Eva, Welker, Martin-Walter, Alpini, Gianfranco, Koch, Christine, Bette, Theresa, Waidmann, Oliver, Filmann, Natalie, Schrecker, Christopher, Trojan, Jörg, Weiler, Nina, Vermehren, Johannes, Schnitzbauer, Andreas, Bechstein, Wolf Otto, Zeuzem, Stefan, Herrmann, Eva, and Welker, Martin-Walter
Abstract: Background/aims: Hepatocellular carcinoma (HCC) is a leading indication for liver transplantation (LT) worldwide. Early identification of patients at risk for HCC recurrence is of paramount importance since early treatment of recurrent HCC after LT may be associated with increased survival. We evaluated incidence of and predictors for HCC recurrence, with a focus on the course of AFP levels. Methods: We performed a retrospective, single-center study of 99 HCC patients who underwent LT between January 28th, 1997 and May 11th, 2016. A multi-stage proportional hazards model with three stages was used to evaluate potential predictive markers, both by univariate and multivariable analysis, for influences on 1) recurrence after transplantation, 2) mortality without HCC recurrence, and 3) mortality after recurrence. Results: 19/99 HCC patients showed recurrence after LT. Waiting time was not associated with overall HCC recurrence (HR = 1, p = 0.979). Similarly, waiting time did not affect mortality in LT recipients both with (HR = 0.97, p = 0.282) or without (HR = 0.99, p = 0.685) HCC recurrence. Log10-transformed AFP values at the time of LT (HR 1.75, p = 0.023) as well as after LT (HR 2.07, p = 0.037) were significantly associated with recurrence. Median survival in patients with a ratio (AFP at recurrence divided by AFP 3 months before recurrence) of 0.5 was greater than 70 months, as compared to a median of only 8 months in patients with a ratio of 5. Conclusion: A rise in AFP levels rather than an absolute threshold could help to identify patients at short-term risk for HCC recurrence post LT, which may allow intensification of the surveillance strategy on an individualized basis.
Published: 2020

20. Evaluating assumptions of scales for subjective assessment of thermal environments – Do laypersons perceive them the way, we researchers believe?

Author: Schweiker, Marcel, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azar, Elie, Bannazadeh, Bahareh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M., Jin, Quan, Jowkar, Mina, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M. C.Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, Mino-Rodriguez, Isabel, Montazami, Azadeh, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Lígia, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, Ma Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, Zomorodian, Zahra Sadat, Schweiker, Marcel, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azar, Elie, Bannazadeh, Bahareh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M., Jin, Quan, Jowkar, Mina, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M. C.Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, Mino-Rodriguez, Isabel, Montazami, Azadeh, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Lígia, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, Ma Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, and Zomorodian, Zahra Sadat
Abstract: People's subjective response to any thermal environment is commonly investigated by using rating scales describing the degree of thermal sensation, comfort, and acceptability. Subsequent analyses of results collected in this way rely on the assumption that specific distances between verbal anchors placed on the scale exist and that relationships between verbal anchors from different dimensions that are assessed (e.g. thermal sensation and comfort) do not change. Another inherent assumption is that such scales are independent of the context in which they are used (climate zone, season, etc.). Despite their use worldwide, there is indication that contextual differences influence the way the scales are perceived and therefore question the reliability of the scales’ interpretation. To address this issue, a large international collaborative questionnaire study was conducted in 26 countries, using 21 different languages, which led to a dataset of 8225 questionnaires. Results, analysed by means of robust statistical techniques, revealed that only a subset of the responses are in accordance with the mentioned assumptions. Significant differences appeared between groups of participants in their perception of the scales, both in relation to distances of the anchors and relationships between scales. It was also found that respondents’ interpretations of scales changed with contextual factors, such as climate, season, and language. These findings highlight the need to carefully consider context-dependent factors in interpreting and reporting results from thermal comfort studies or post-occupancy evaluations, as well as to revisit the use of rating scales and the analysis methods used in thermal comfort studies to improve their reliability.
Published: 2020

21. Evaluating assumptions of scales for subjective assessment of thermal environments – Do laypersons perceive them the way, we researchers believe?

Author: Schweiker, Marcel, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azar, Elie, Bannazadeh, Bahareh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T, Huebner, Gesche M, Jin, Quan, Jowkar, Mina, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M C Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, Mino-Rodriguez, Isabel, Montazami, Azadeh, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Lígia, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F, Rivera, Ma Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B, Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, Zomorodian, Zahra Sadat, Schweiker, Marcel, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azar, Elie, Bannazadeh, Bahareh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T, Huebner, Gesche M, Jin, Quan, Jowkar, Mina, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M C Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, Mino-Rodriguez, Isabel, Montazami, Azadeh, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Lígia, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F, Rivera, Ma Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B, Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, and Zomorodian, Zahra Sadat
Abstract: People's subjective response to any thermal environment is commonly investigated by using rating scales describing the degree of thermal sensation, comfort, and acceptability. Subsequent analyses of results collected in this way rely on the assumption that specific distances between verbal anchors placed on the scale exist and that relationships between verbal anchors from different dimensions that are assessed (e.g. thermal sensation and comfort) do not change. Another inherent assumption is that such scales are independent of the context in which they are used (climate zone, season, etc.). Despite their use worldwide, there is indication that contextual differences influence the way the scales are perceived and therefore question the reliability of the scales’ interpretation. To address this issue, a large international collaborative questionnaire study was conducted in 26 countries, using 21 different languages, which led to a dataset of 8225 questionnaires. Results, analysed by means of robust statistical techniques, revealed that only a subset of the responses are in accordance with the mentioned assumptions. Significant differences appeared between groups of participants in their perception of the scales, both in relation to distances of the anchors and relationships between scales. It was also found that respondents’ interpretations of scales changed with contextual factors, such as climate, season, and language. These findings highlight the need to carefully consider context-dependent factors in interpreting and reporting results from thermal comfort studies or post-occupancy evaluations, as well as to revisit the use of rating scales and the analysis methods used in thermal comfort studies to improve their reliability.
Published: 2020

22. Evaluating assumptions of scales for subjective assessment of thermal environments – Do laypersons perceive them the way, we researchers believe?

Author: Schweiker, Marcel, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azar, Elie, Bannazadeh, Bahareh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T, Huebner, Gesche M, Jin, Quan, Jowkar, Mina, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M C Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, Mino-Rodriguez, Isabel, Montazami, Azadeh, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Lígia, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F, Rivera, Ma Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B, Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, Zomorodian, Zahra Sadat, Schweiker, Marcel, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azar, Elie, Bannazadeh, Bahareh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T, Huebner, Gesche M, Jin, Quan, Jowkar, Mina, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M C Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, Mino-Rodriguez, Isabel, Montazami, Azadeh, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Lígia, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F, Rivera, Ma Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B, Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, and Zomorodian, Zahra Sadat
Abstract: People's subjective response to any thermal environment is commonly investigated by using rating scales describing the degree of thermal sensation, comfort, and acceptability. Subsequent analyses of results collected in this way rely on the assumption that specific distances between verbal anchors placed on the scale exist and that relationships between verbal anchors from different dimensions that are assessed (e.g. thermal sensation and comfort) do not change. Another inherent assumption is that such scales are independent of the context in which they are used (climate zone, season, etc.). Despite their use worldwide, there is indication that contextual differences influence the way the scales are perceived and therefore question the reliability of the scales’ interpretation. To address this issue, a large international collaborative questionnaire study was conducted in 26 countries, using 21 different languages, which led to a dataset of 8225 questionnaires. Results, analysed by means of robust statistical techniques, revealed that only a subset of the responses are in accordance with the mentioned assumptions. Significant differences appeared between groups of participants in their perception of the scales, both in relation to distances of the anchors and relationships between scales. It was also found that respondents’ interpretations of scales changed with contextual factors, such as climate, season, and language. These findings highlight the need to carefully consider context-dependent factors in interpreting and reporting results from thermal comfort studies or post-occupancy evaluations, as well as to revisit the use of rating scales and the analysis methods used in thermal comfort studies to improve their reliability.
Published: 2020

23. Evaluating assumptions of scales for subjective assessment of thermal environments – Do laypersons perceive them the way, we researchers believe?

Author: Schweiker, Marcel, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azar, Elie, Bannazadeh, Bahareh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon-Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M, Jin, Quan, Jowkar, Mina, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M.C. Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, Mino-Rodriguez, Isabel, Montazami, Azadeh, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Lígia, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, Ma Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, Zomorodian, ZahraSadat, Schweiker, Marcel, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azar, Elie, Bannazadeh, Bahareh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon-Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M, Jin, Quan, Jowkar, Mina, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M.C. Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, Mino-Rodriguez, Isabel, Montazami, Azadeh, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Lígia, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, Ma Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, and Zomorodian, ZahraSadat
Abstract: People's subjective response to any thermal environment is commonly investigated by using rating scales describing the degree of thermal sensation, comfort, and acceptability. Subsequent analyses of results collected in this way rely on the assumption that specific distances between verbal anchors placed on the scale exist and that relationships between verbal anchors from different dimensions that are assessed (e.g. thermal sensation and comfort) do not change. Another inherent assumption is that such scales are independent of the context in which they are used (climate zone, season, etc.). Despite their use worldwide, there is indication that contextual differences influence the way the scales are perceived and therefore question the reliability of the scales’ interpretation. To address this issue, a large international collaborative questionnaire study was conducted in 26 countries, using 21 different languages, which led to a dataset of 8225 questionnaires. Results, analysed by means of robust statistical techniques, revealed that only a subset of the responses are in accordance with the mentioned assumptions. Significant differences appeared between groups of participants in their perception of the scales, both in relation to distances of the anchors and relationships between scales. It was also found that respondents’ interpretations of scales changed with contextual factors, such as climate, season, and language. These findings highlight the need to carefully consider context-dependent factors in interpreting and reporting results from thermal comfort studies or post-occupancy evaluations, as well as to revisit the use of rating scales and the analysis methods used in thermal comfort studies to improve their reliability.
Published: 2020

24. Cabozantinib for the treatment of advanced hepatocellular carcinoma: current data and future perspectives

Author: Trojan, Jörg and Trojan, Jörg
Abstract: Cabozantinib (Cabometyx®) is a potent multikinase inhibitor targeting the vascular endothelial growth factor (VEGF) receptor 2, the mesenchymal-epithelial transition factor (MET) receptor, and the “anexelekto” (AXL) receptor tyrosine kinase. It is approved for the treatment of advanced hepatocellular carcinoma (HCC) after failure of sorafenib in Europe (since November 2018) and in the USA (since January 2019). The approval of cabozantinib was based on results of the randomized, placebo-controlled, phase 3 CELESTIAL trial in patients with unresectable HCC, who received one or two prior lines of treatment including sorafenib. At the second planned interim analysis, the trial was stopped, because the primary end point overall survival was clearly in favor for cabozantinib. Additionally, median progression-free survival was superior to placebo. The most common ≥ grade 3 relevant adverse events in patients with HCC treated with cabozantinib were palmar–plantar erythrodysesthesia, hypertension, fatigue, and diarrhea. In this review, current data on cabozantinib for the treatment of patients with advanced HCC, with a focus on the management of common adverse events and ongoing clinical trials, are discussed.
Published: 2020

25. The Scales Project, a cross-national dataset on the interpretation of thermal perception scales.

Author: Schweiker, Marcel, Schweiker, Marcel, Abdul-Zahra, Amar, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha, Azadeh, Montazami, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon-Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti, Daniel, Lyrian, Vecchi, Renata, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla, Harimi, Djamila, Hellwig, Runa, Huebner, Gesche, Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, McGill, Gráinne, Mino-Rodriguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph, Rivera, Ma, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu, Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, Zomorodian, Zahra, Schweiker, Marcel, Schweiker, Marcel, Abdul-Zahra, Amar, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha, Azadeh, Montazami, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon-Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti, Daniel, Lyrian, Vecchi, Renata, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla, Harimi, Djamila, Hellwig, Runa, Huebner, Gesche, Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, McGill, Gráinne, Mino-Rodriguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph, Rivera, Ma, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu, Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, and Zomorodian, Zahra
Abstract: Thermal discomfort is one of the main triggers for occupants interactions with components of the built environment such as adjustments of thermostats and/or opening windows and strongly related to the energy use in buildings. Understanding causes for thermal (dis-)comfort is crucial for design and operation of any type of building. The assessment of human thermal perception through rating scales, for example in post-occupancy studies, has been applied for several decades; however, long-existing assumptions related to these rating scales had been questioned by several researchers. The aim of this study was to gain deeper knowledge on contextual influences on the interpretation of thermal perception scales and their verbal anchors by survey participants. A questionnaire was designed and consequently applied in 21 language versions. These surveys were conducted in 57 cities in 30 countries resulting in a dataset containing responses from 8225 participants. The database offers potential for further analysis in the areas of building design and operation, psycho-physical relationships between human perception and the built environment, and linguistic analyses.
Published: 2019

26. The Scales Project, a cross-national dataset on the interpretation of thermal perception scales

Author: Schweiker, Marcel, Abdul-Zahra, Amar, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azadeh, Montazami, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon-ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M., Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M.C. Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, Mcgill, Gráinne, Mino-Rodriguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Ligia, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, Ma. Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, null, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, Zomorodian, Zahra Sadat, Schweiker, Marcel, Abdul-Zahra, Amar, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azadeh, Montazami, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon-ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M., Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M.C. Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, Mcgill, Gráinne, Mino-Rodriguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Ligia, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, Ma. Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, null, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, and Zomorodian, Zahra Sadat
Abstract: Thermal discomfort is one of the main triggers for occupants’ interactions with components of the built environment such as adjustments of thermostats and/or opening windows and strongly related to the energy use in buildings. Understanding causes for thermal (dis-)comfort is crucial for design and operation of any type of building. The assessment of human thermal perception through rating scales, for example in post-occupancy studies, has been applied for several decades; however, long-existing assumptions related to these rating scales had been questioned by several researchers. The aim of this study was to gain deeper knowledge on contextual influences on the interpretation of thermal perception scales and their verbal anchors by survey participants. A questionnaire was designed and consequently applied in 21 language versions. These surveys were conducted in 57 cities in 30 countries resulting in a dataset containing responses from 8225 participants. The database offers potential for further analysis in the areas of building design and operation, psycho-physical relationships between human perception and the built environment, and linguistic analyses., Thermal discomfort is one of the main triggers for occupants’ interactions with components of the built environment such as adjustments of thermostats and/or opening windows and strongly related to the energy use in buildings. Understanding causes for thermal (dis-)comfort is crucial for design and operation of any type of building. The assessment of human thermal perception through rating scales, for example in post-occupancy studies, has been applied for several decades; however, long-existing assumptions related to these rating scales had been questioned by several researchers. The aim of this study was to gain deeper knowledge on contextual influences on the interpretation of thermal perception scales and their verbal anchors by survey participants. A questionnaire was designed and consequently applied in 21 language versions. These surveys were conducted in 57 cities in 30 countries resulting in a dataset containing responses from 8225 participants. The database offers potential for further analysis in the areas of building design and operation, psycho-physical relationships between human perception and the built environment, and linguistic analyses.
Published: 2019

27. The Scales Project, a cross-national dataset on the interpretation of thermal perception scales.

Author: Schweiker, Marcel, Schweiker, Marcel, Abdul-Zahra, Amar, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azadeh, Montazami, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon-Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, Vecchi, Renata De, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T, Huebner, Gesche M, Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, MC Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, McGill, Gráinne, Mino-Rodriguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Ligia, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F, Rivera, Ma Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B, Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, Zomorodian, Zahra Sadat, Schweiker, Marcel, Schweiker, Marcel, Abdul-Zahra, Amar, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azadeh, Montazami, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon-Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, Vecchi, Renata De, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T, Huebner, Gesche M, Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, MC Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, McGill, Gráinne, Mino-Rodriguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Ligia, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F, Rivera, Ma Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B, Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, and Zomorodian, Zahra Sadat
Abstract: Thermal discomfort is one of the main triggers for occupants' interactions with components of the built environment such as adjustments of thermostats and/or opening windows and strongly related to the energy use in buildings. Understanding causes for thermal (dis-)comfort is crucial for design and operation of any type of building. The assessment of human thermal perception through rating scales, for example in post-occupancy studies, has been applied for several decades; however, long-existing assumptions related to these rating scales had been questioned by several researchers. The aim of this study was to gain deeper knowledge on contextual influences on the interpretation of thermal perception scales and their verbal anchors by survey participants. A questionnaire was designed and consequently applied in 21 language versions. These surveys were conducted in 57 cities in 30 countries resulting in a dataset containing responses from 8225 participants. The database offers potential for further analysis in the areas of building design and operation, psycho-physical relationships between human perception and the built environment, and linguistic analyses.
Published: 2019

28. The Scales Project, a cross-national dataset on the interpretation of thermal perception scales

Author: Universidad de Sevilla. Departamento de Construcciones Arquitectónicas I (ETSA), Universidad de Sevilla. TEP130: Arquitectura, Patrimonio y Sostenibilidad: Acústica, Iluminación, Óptica y Energía, Heidelberg Academy of Sciences and Humanities, National Natural Science Foundation of China, National Research Foundation of Korea, Marcel Schweiker, Amar Abdul-Zahra, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Montazami, Azadeh, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jessica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M., Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M. C. Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Olweny, Mark, Marín Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, McGill, Gráinne, Mino Rodríguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Ouyang, Wanlu, Papst de Abreu, Ana Lígia, Pérez Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, María Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, Zomorodian, Zahra Sadat, Universidad de Sevilla. Departamento de Construcciones Arquitectónicas I (ETSA), Universidad de Sevilla. TEP130: Arquitectura, Patrimonio y Sostenibilidad: Acústica, Iluminación, Óptica y Energía, Heidelberg Academy of Sciences and Humanities, National Natural Science Foundation of China, National Research Foundation of Korea, Marcel Schweiker, Amar Abdul-Zahra, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Montazami, Azadeh, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jessica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M., Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M. C. Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Olweny, Mark, Marín Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, McGill, Gráinne, Mino Rodríguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Ouyang, Wanlu, Papst de Abreu, Ana Lígia, Pérez Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, María Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, and Zomorodian, Zahra Sadat
Abstract: Thermal discomfort is one of the main triggers for occupants’ interactions with components of the built environment such as adjustments of thermostats and/or opening windows and strongly related to the energy use in buildings. Understanding causes for thermal (dis-)comfort is crucial for design and operation of any type of building. The assessment of human thermal perception through rating scales, for example in post-occupancy studies, has been applied for several decades; however, long-existing assumptions related to these rating scales had been questioned by several researchers. The aim of this study was to gain deeper knowledge on contextual influences on the interpretation of thermal perception scales and their verbal anchors by survey participants. A questionnaire was designed and consequently applied in 21 language versions. These surveys were conducted in 57 cities in 30 countries resulting in a dataset containing responses from 8225 participants. The database offers potential for further analysis in the areas of building design and operation, psycho-physical relationships between human perception and the built environment, and linguistic analyses.
Published: 2019

29. The Scales Project, a cross-national dataset on the interpretation of thermal perception scales

Author: Universidad de Sevilla. Departamento de Construcciones Arquitectónicas I (ETSA), Universidad de Sevilla. TEP130: Arquitectura, Patrimonio y Sostenibilidad: Acústica, Iluminación, Óptica y Energía, Heidelberg Academy of Sciences and Humanities, National Natural Science Foundation of China, National Research Foundation of Korea, Marcel Schweiker, Amar Abdul-Zahra, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Montazami, Azadeh, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jessica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M., Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M. C. Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Olweny, Mark, Marín Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, McGill, Gráinne, Mino Rodríguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Ouyang, Wanlu, Papst de Abreu, Ana Lígia, Pérez Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, María Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, Zomorodian, Zahra Sadat, Universidad de Sevilla. Departamento de Construcciones Arquitectónicas I (ETSA), Universidad de Sevilla. TEP130: Arquitectura, Patrimonio y Sostenibilidad: Acústica, Iluminación, Óptica y Energía, Heidelberg Academy of Sciences and Humanities, National Natural Science Foundation of China, National Research Foundation of Korea, Marcel Schweiker, Amar Abdul-Zahra, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Montazami, Azadeh, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jessica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M., Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M. C. Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Olweny, Mark, Marín Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, McGill, Gráinne, Mino Rodríguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Ouyang, Wanlu, Papst de Abreu, Ana Lígia, Pérez Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, María Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, and Zomorodian, Zahra Sadat
Abstract: Thermal discomfort is one of the main triggers for occupants’ interactions with components of the built environment such as adjustments of thermostats and/or opening windows and strongly related to the energy use in buildings. Understanding causes for thermal (dis-)comfort is crucial for design and operation of any type of building. The assessment of human thermal perception through rating scales, for example in post-occupancy studies, has been applied for several decades; however, long-existing assumptions related to these rating scales had been questioned by several researchers. The aim of this study was to gain deeper knowledge on contextual influences on the interpretation of thermal perception scales and their verbal anchors by survey participants. A questionnaire was designed and consequently applied in 21 language versions. These surveys were conducted in 57 cities in 30 countries resulting in a dataset containing responses from 8225 participants. The database offers potential for further analysis in the areas of building design and operation, psycho-physical relationships between human perception and the built environment, and linguistic analyses.
Published: 2019

30. Evaluation of EGFR inhibitor‐mediated acneiform skin toxicity within the double‐blind randomized EVITA trial: A thorough gender‐specific analysis using the WoMo score

Author: Gaiser, Maria, Lorenzen, Sylvie, Merx, Kirsten, Trojan, Jörg, Ocvirk, Janja, Ettrich, Thomas Jens, Batran, Salah-Eddin al, Schulz, Holger, Homann, Nils, Feustel, Hans‐Peter, Schatz, Michael, Kripp, Melanie, Schulte, Nadine, Heeger, Steffen, Vlassak, Soetkin, Koch, Winfried, Hofheinz, Ralf-Dieter, Gaiser, Maria, Lorenzen, Sylvie, Merx, Kirsten, Trojan, Jörg, Ocvirk, Janja, Ettrich, Thomas Jens, Batran, Salah-Eddin al, Schulz, Holger, Homann, Nils, Feustel, Hans‐Peter, Schatz, Michael, Kripp, Melanie, Schulte, Nadine, Heeger, Steffen, Vlassak, Soetkin, Koch, Winfried, and Hofheinz, Ralf-Dieter
Abstract: Acne‐like skin reactions frequently occur in patients undergoing treatment with drugs inhibiting the epidermal growth factor receptor. Recently, the effects of vitamin K1 containing cream (Reconval K1) as prophylactic skin treatment in addition to doxycycline were explored in a double‐blind randomized phase II trial (EVITA) in patients with metastatic colorectal cancer receiving cetuximab. EVITA demonstrated a trend towards less severe skin rash in Reconval K1‐treated patients using the tripartite WoMo skin reaction grading score as a thorough tool for quantification of drug related skin reactions. This gender‐specific analysis of the EVITA trial evaluated the application of the WoMo score for assessment of epidermal growth factor receptor (EGFR)‐related skin toxicities according to treatment arm and gender. To show the robustness of results parametric and non‐parametric statistical analyses were conducted. All three parts of the WoMo score independently demonstrated the superiority of the treatment arm (Reconval K1) regarding a significant reduction in acneiform skin reactions in women. Men did not benefit from Reconval K1 cream at any time point in none of the WoMo score analyses. The treatment effect in women was confirmed by the use of skin rash categories based on the final WoMo overall score and mixed effect longitudinal multiple linear regression analysis. The WoMo score represents a sensitive tool for studies exploiting treatments against EGFR mediated acne‐like skin rash. Part C of the WoMo score seems to be sufficient for quantification of drug related skin toxicities in further studies. Standard WoMo skin reaction score values for future studies are provided.
Published: 2019

31. Sarcopenia as a prognostic factor for survival in patients with locally advanced gastroesophageal adenocarcinoma

Author: de Mello, Ramon Andrade, Koch, Christine, Reitz, Cornelius-Emanuel Thomas, Schreckenbach, Teresa, Eichler, Katrin, Filmann, Natalie, Batran, Salah-Eddin al, Götze, Thorsten, Zeuzem, Stefan, Bechstein, Wolf Otto, Kraus, Thomas, Bojunga, Jörg, Düx, Markus, Trojan, Jörg, Blumenstein, Irina Ursula, de Mello, Ramon Andrade, Koch, Christine, Reitz, Cornelius-Emanuel Thomas, Schreckenbach, Teresa, Eichler, Katrin, Filmann, Natalie, Batran, Salah-Eddin al, Götze, Thorsten, Zeuzem, Stefan, Bechstein, Wolf Otto, Kraus, Thomas, Bojunga, Jörg, Düx, Markus, Trojan, Jörg, and Blumenstein, Irina Ursula
Abstract: Background and aims: Patients with gastric cancer often show signs of malnutrition. We sought to evaluate the influence of sarcopenia in patients with locally advanced, not metastasized, gastric or gastro-esophageal junction (GEJ) cancer undergoing curative treatment (perioperative chemotherapy and surgery) on morbidity and mortality in order to identify patients in need for nutritional intervention. Patients and methods: Two-centre study, conducted in the Frankfurt University Clinic and Krankenhaus Nordwest (Frankfurt) as part of the University Cancer Center Frankfurt (UCT). 47/83 patients were treated in the FLOT trial (NCT01216644). Patients´ charts were reviewed for clinical data. Two consecutive CT scans were retrospectively analyzed to determine the degree of sarcopenia. Survival was calculated using the Kaplan-Meier method, multivariate analysis was performed using the Cox regression. Results: 60 patients (72.3%) were male and 23 (27.7%) female. 45 patients (54.2%) had GEJ type 1–3 and 38 (45.8%) gastric tumors, respectively. Sarcopenic patients were significantly older than non-sarcopenic patients (mean age 65.1 years vs. 59.5 years, p = 0.042), terminated the chemotherapy significantly earlier (50% vs. 22.6%, p = 0.037) and showed higher Clavien-Dindo scores, indicating more severe perioperative complications (score ≥3 43.3 vs. 17.0%, p = 0.019). Sarcopenic patients had a significantly shorter survival than non-sarcopenic patients (139.6 ± 19.5 [95% CI, 101.3–177.9] vs. 206.7 ± 13.8 [95% CI, 179.5–233.8] weeks, p = 0.004). Multivariate Cox regression analysis showed that, besides UICC stage, sarcopenia significantly influenced survival. Conclusion: Sarcopenia is present in a large proportion of patients with locally advanced gastric or GEJ cancer and significantly influences tolerability of chemotherapy, surgical complications and survival.
Published: 2019

32. The Scales Project, a cross-national dataset on the interpretation of thermal perception scales

Author: Schweiker, Marcel, Abdul-Zahra, Amar, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azadeh, Montazami, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon-ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M., Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M.C. Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, Mcgill, Gráinne, Mino-Rodriguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Ligia, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, Ma. Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, null, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, Zomorodian, Zahra Sadat, Schweiker, Marcel, Abdul-Zahra, Amar, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azadeh, Montazami, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon-ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M., Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M.C. Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, Mcgill, Gráinne, Mino-Rodriguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Ligia, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, Ma. Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, null, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, and Zomorodian, Zahra Sadat
Abstract: Thermal discomfort is one of the main triggers for occupants’ interactions with components of the built environment such as adjustments of thermostats and/or opening windows and strongly related to the energy use in buildings. Understanding causes for thermal (dis-)comfort is crucial for design and operation of any type of building. The assessment of human thermal perception through rating scales, for example in post-occupancy studies, has been applied for several decades; however, long-existing assumptions related to these rating scales had been questioned by several researchers. The aim of this study was to gain deeper knowledge on contextual influences on the interpretation of thermal perception scales and their verbal anchors by survey participants. A questionnaire was designed and consequently applied in 21 language versions. These surveys were conducted in 57 cities in 30 countries resulting in a dataset containing responses from 8225 participants. The database offers potential for further analysis in the areas of building design and operation, psycho-physical relationships between human perception and the built environment, and linguistic analyses., Thermal discomfort is one of the main triggers for occupants’ interactions with components of the built environment such as adjustments of thermostats and/or opening windows and strongly related to the energy use in buildings. Understanding causes for thermal (dis-)comfort is crucial for design and operation of any type of building. The assessment of human thermal perception through rating scales, for example in post-occupancy studies, has been applied for several decades; however, long-existing assumptions related to these rating scales had been questioned by several researchers. The aim of this study was to gain deeper knowledge on contextual influences on the interpretation of thermal perception scales and their verbal anchors by survey participants. A questionnaire was designed and consequently applied in 21 language versions. These surveys were conducted in 57 cities in 30 countries resulting in a dataset containing responses from 8225 participants. The database offers potential for further analysis in the areas of building design and operation, psycho-physical relationships between human perception and the built environment, and linguistic analyses.
Published: 2019

33. The Scales Project, a cross-national dataset on the interpretation of thermal perception scales

Author: Schweiker, Marcel, Abdul-Zahra, Amar, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azadeh, Montazami, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, Vecchi, Renata De, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M., Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M. C.Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, McGill, Gráinne, Mino-Rodriguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Ligia, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, Ma Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, Zomorodian, Zahra Sadat, Schweiker, Marcel, Abdul-Zahra, Amar, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azadeh, Montazami, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, Vecchi, Renata De, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M., Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M. C.Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, McGill, Gráinne, Mino-Rodriguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Ligia, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, Ma Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, and Zomorodian, Zahra Sadat
Abstract: Thermal discomfort is one of the main triggers for occupants’ interactions with components of the built environment such as adjustments of thermostats and/or opening windows and strongly related to the energy use in buildings. Understanding causes for thermal (dis-)comfort is crucial for design and operation of any type of building. The assessment of human thermal perception through rating scales, for example in post-occupancy studies, has been applied for several decades; however, long-existing assumptions related to these rating scales had been questioned by several researchers. The aim of this study was to gain deeper knowledge on contextual influences on the interpretation of thermal perception scales and their verbal anchors by survey participants. A questionnaire was designed and consequently applied in 21 language versions. These surveys were conducted in 57 cities in 30 countries resulting in a dataset containing responses from 8225 participants. The database offers potential for further analysis in the areas of building design and operation, psycho-physical relationships between human perception and the built environment, and linguistic analyses.
Published: 2019

34. The Scales Project, a cross-national dataset on the interpretation of thermal perception scales

Author: Schweiker, Marcel, Abdul-Zahra, Amar, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azadeh, Montazami, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, Vecchi, Renata De, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M., Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M. C.Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, McGill, Gráinne, Mino-Rodriguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Ligia, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, Ma Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, Zomorodian, Zahra Sadat, Schweiker, Marcel, Abdul-Zahra, Amar, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azadeh, Montazami, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, Vecchi, Renata De, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche M., Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M. C.Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, McGill, Gráinne, Mino-Rodriguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana Ligia, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, Ma Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, and Zomorodian, Zahra Sadat
Abstract: Thermal discomfort is one of the main triggers for occupants’ interactions with components of the built environment such as adjustments of thermostats and/or opening windows and strongly related to the energy use in buildings. Understanding causes for thermal (dis-)comfort is crucial for design and operation of any type of building. The assessment of human thermal perception through rating scales, for example in post-occupancy studies, has been applied for several decades; however, long-existing assumptions related to these rating scales had been questioned by several researchers. The aim of this study was to gain deeper knowledge on contextual influences on the interpretation of thermal perception scales and their verbal anchors by survey participants. A questionnaire was designed and consequently applied in 21 language versions. These surveys were conducted in 57 cities in 30 countries resulting in a dataset containing responses from 8225 participants. The database offers potential for further analysis in the areas of building design and operation, psycho-physical relationships between human perception and the built environment, and linguistic analyses.
Published: 2019

35. The Scales Project, a cross-national dataset on the interpretation of thermal perception scales

Author: Schweiker, Marcel, Abdul-Zahra, Amar, Afonso de Andre, Maria, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azadeh, Montazami, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon-Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche, Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, Jeffrey M.C., Lindermayr, Vanessa, Mahaki, Mohammadbagher, Udochukwu, Marcel-Okafor, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, McGill, Gráinne, Mino-Rodriguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, de Abreu, Ana Ligia Papst, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, Ma Isabel, Salmanzadeh, Mazyar, Schakib‐Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Tahsildoost, Mohammad, Federico Tartarini, Federico, Despoina, Teli, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, Zomorodian, Zahra Sadat, Schweiker, Marcel, Abdul-Zahra, Amar, Afonso de Andre, Maria, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azadeh, Montazami, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon-Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T., Huebner, Gesche, Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M. Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, Jeffrey M.C., Lindermayr, Vanessa, Mahaki, Mohammadbagher, Udochukwu, Marcel-Okafor, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, McGill, Gráinne, Mino-Rodriguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, de Abreu, Ana Ligia Papst, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F., Rivera, Ma Isabel, Salmanzadeh, Mazyar, Schakib‐Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Tahsildoost, Mohammad, Federico Tartarini, Federico, Despoina, Teli, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B., Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, and Zomorodian, Zahra Sadat
Abstract: Contribution: The methods described below were developed within IEA EBC Annex 69 through several discussion rounds between an international and interdisciplinary group of researchers from the field of thermal comfort – the initial core group. Runa T. Hellwig (R.T.H.) is part of the initial group and contributed to 7 datasets DEHSA, was involved in preparing the English version, translating and piloting the German version and development of methods. Data were collected during my previous work at Augsburg University of Applied Sciences, Germany My work at Aalborg University was supported by the Obelske Familiefond, Denmark. Abstract Thermal discomfort is one of the main triggers for occupants’ interactions with components of the built environment such as adjustments of thermostats and/or opening windows and strongly related to the energy use in buildings. Understanding causes for thermal (dis-)comfort is crucial for design and operation of any type of building. The assessment of human thermal perception through rating scales, for example in post-occupancy studies, has been applied for several decades; however, long-existing assumptions related to these rating scales had been questioned by several researchers. The aim of this study was to gain deeper knowledge on contextual influences on the interpretation of thermal perception scales and their verbal anchors by survey participants. A questionnaire was designed and consequently applied in 21 language versions. These surveys were conducted in 57 cities in 30 countries resulting in a dataset containing responses from 8225 participants. The database offers potential for further analysis in the areas of building design and operation, psycho-physical relationships between human perception and the built environment, and linguistic analyses.
Published: 2019

36. The restorative value of the urban environment: A systematic review of the literature.

Author: Weber, Anke Maria, Trojan, Jörg, Weber, Anke Maria, and Trojan, Jörg
Abstract: Background: Stress poses a major issue in our modern society, making restoration an important research focus. Restoration likelihood has mostly been observed in nature, which was compared with urban environments that have little restorative potential, eg, industrial areas. However, many people reside in and need to find restoration in cities. The main aim of this review is to summarize research that has focused on investigating restoration possibilities in urban environments and the environmental elements interacting with the restoration likelihood of an urban environment. Method: This review focuses on studies addressing the topic of restoration possibilities in urban settings in built and human-made natural urban environments. The studies were searched via Google Scholar, PsycINFO, PsycARTICLES, and PSYNDEX. All studies concerned with restoration in urban environments were included. However, studies concerned with nonoriginal data, solely investigating effects of natural environments or treating urban environments as a control for restoration in nature, were excluded from the review. Overall, 39 studies corresponded to the criteria and were included. Results: Natural elements in urban environments have a restorative potential and can increase the restorativeness of urban settings. Furthermore, built urban environments vary in their restorative potential, but promising results have been uncovered as well. Architectural elements, cultural, and leisure areas had a restorative value, whereas the findings on streets and residential areas differ. In sum, many urban locations can have restorative effects, but these effects may be influenced by factors such as cultural background, age, social components, and individual dispositions. Discussion: Certain urban environments hold a restorative potential. However, the literature on restoration in urban environments is still quite scarce and therefore has been of little practical use. Even though applying the findings to real-l
Published: 2018

37. Vitamin K1 cream significantly reduces incidence and severity of cetuximab-related acneiform skin rash in women: a post hoc analysis of the EVITA trial

Author: Gaiser, Maria, Lorenzen, Sylvie, Merx, Kirsten, Trojan, Jörg, Ocvirk, Janja, Ettrich, Thomas Jens, Batran, Salah-Eddin al, Schulz, Holger, Homann, Nils, Feustel, Hans-Peter, Schatz, Michael, Kripp, Melanie, Schulte, Nadine, Heeger, Steffen, Vlassak, Soetkin, Koch, Winfried, Hofheinz, Ralf-Dieter, Gaiser, Maria, Lorenzen, Sylvie, Merx, Kirsten, Trojan, Jörg, Ocvirk, Janja, Ettrich, Thomas Jens, Batran, Salah-Eddin al, Schulz, Holger, Homann, Nils, Feustel, Hans-Peter, Schatz, Michael, Kripp, Melanie, Schulte, Nadine, Heeger, Steffen, Vlassak, Soetkin, Koch, Winfried, and Hofheinz, Ralf-Dieter
Abstract: Patients treated with drugs targeting the epidermal growth factor receptor (EGFR) frequently develop acneiform skin toxicities. These skin reactions can impair treatment adherence and clinical outcome. Prophylactic treatment with doxycycline reduces the severity of skin toxicities. ...
Published: 2018

38. Circulating hypoxia marker carbonic anhydrase IX (CA9) in patients with hepatocellular carcinoma and patients with cirrhosis

Author: Avila, Matias A., Finkelmeier, Fabian, Canli, Özge, Peiffer, Kai-Henrik, Walter, Dirk Henning, Tal, Andrea Oliver, Koch, Christine, Pession, Ursula, Vermehren, Johannes, Trojan, Jörg, Zeuzem, Stefan, Piiper, Albrecht, Greten, Florian, Grammatikos, Georgios, Waidmann, Oliver, Avila, Matias A., Finkelmeier, Fabian, Canli, Özge, Peiffer, Kai-Henrik, Walter, Dirk Henning, Tal, Andrea Oliver, Koch, Christine, Pession, Ursula, Vermehren, Johannes, Trojan, Jörg, Zeuzem, Stefan, Piiper, Albrecht, Greten, Florian, Grammatikos, Georgios, and Waidmann, Oliver
Abstract: Background and aims: Expression of carbonic anhydrase IX (CA9), an enzyme expressed in response to hypoxia, acidosis and oncogenic alterations, is reported to be a prognostic factor in HCC patients. Here we evaluated serum CA9 levels in HCC and cirrhosis patients. Methods: HCC and cirrhosis patients were prospectively recruited and CA9 levels were determined. CA9 levels were compared to stages of cirrhosis and HCC stages. The association of the CA9 levels and overall survival (OS) was assessed. Furthermore, immunohistochemical CA9 expression in HCC and cirrhosis was evaluated. Results: 215 patients with HCC were included. The median serum CA9 concentration in patients with HCC was 370 pg/ml and significantly higher than in a healthy cohort. Patients with advanced cancer stages (BCLC and ALBI score) had hid significant higher levels of CA9 in the serum. HCC patients with high serum CA9 concentrations (>400 pg/ml) had an increased mortality risk (hazard ratio (HR) 1.690, 95% confidence interval (CI) 1.017–2.809, P = 0.043). Serum CA9 concentration in cirrhotic patients did not differ significantly from HCC patients. Higher CA9 levels in cirrhotic patients correlated with portal hypertension and esophageal varices. Patients with ethanol induced cirrhosis had the highest CA9 levels in both cohorts. Levels of CA9 did not correlate with immunohistochemical expression. Conclusions: We conclude that a high CA9 level is a possible prognostic indicator for a poor outcome in HCC patients. The high CA9 levels are probably mainly associated with portal hypertension. Ductular reactions might be a possible source of serum CA9.
Published: 2018

39. Prognostic value of the neutrophil-to-lymphocyte ratio in the ARQ 197-215 second-line study for advanced hepatocellular carcinoma.

Author: UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (SLuc) Service de gastro-entérologie, Personeni, Nicola, Giordano, Laura, Abbadessa, Giovanni, Porta, Camillo, Borbath, Ivan, Daniele, Bruno, Van Laethem, Jean-Luc, Van Vlierberghe, Hans, Trojan, Jörg, De Toni, Enrico N, Gasbarrini, Antonio, Lencioni, Monica, Lamar, Maria E, Wang, Yunxia, Shuster, Dale, Schwartz, Brian, Santoro, Armando, Rimassa, Lorenza, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (SLuc) Service de gastro-entérologie, Personeni, Nicola, Giordano, Laura, Abbadessa, Giovanni, Porta, Camillo, Borbath, Ivan, Daniele, Bruno, Van Laethem, Jean-Luc, Van Vlierberghe, Hans, Trojan, Jörg, De Toni, Enrico N, Gasbarrini, Antonio, Lencioni, Monica, Lamar, Maria E, Wang, Yunxia, Shuster, Dale, Schwartz, Brian, Santoro, Armando, and Rimassa, Lorenza
Abstract: The ARQ 197-215 study randomized patients to tivantinib or placebo and pre-specified efficacy analyses indicated the predictive value of MET expression as a marker of benefit from tivantinib in hepatocellular carcinoma (HCC). We aimed to explore the neutrophil-to-lymphocyte ratio (NLR) in 98 ARQ 197-215 patients with available absolute neutrophil count and absolute lymphocyte count at baseline. The cut-off value used to define high versus low NLR was 3.0. In univariate analysis, high NLR was associated with hazard ratio (HR) for overall survival (OS) of 1.58 [95% confidence interval (CI) 1.01; 2.47; P <0.046], corresponding to median OS of 5.1 months versus 7.8 months in patients with low NLR (P = 0.044). In contrast, time to progression was not significantly affected by NLR (P = 0.20). Multivariable model confirmed that both NLR >3 (P = 0.03) and presence of vascular invasion (P = 0.017) were negatively associated with OS. After adjustment for vascular invasion, NLR independently predicted survival in both the placebo and the tivantinib cohort. For OS, no interaction was detected between NLR status and treatment (Pinteraction = 0.40). Baseline NLR is an independent prognostic biomarker in patients with HCC and compensated liver function who are candidate for second-line treatments.
Published: 2017

40. Bevacizumab-based first-line chemotherapy in elderly patients with metastatic colorectal cancer : an individual patient data based meta-analysis

Author: Koch, Christine, Schwing, Anna M., Herrmann, Eva, Borner, Markus, Díaz-Rubio, Eduardo, Dotan, Efrat, Feliu, Jaime, Okita, Natsuko, Souglakos, John, Arkenau, Hendrik-Tobias, Porschen, Rainer, Koopman, Miriam, Punt, Cornelis J. A., Gramont, Aimery de, Tournigand, Christophe, Zeuzem, Stefan, Trojan, Jörg, Koch, Christine, Schwing, Anna M., Herrmann, Eva, Borner, Markus, Díaz-Rubio, Eduardo, Dotan, Efrat, Feliu, Jaime, Okita, Natsuko, Souglakos, John, Arkenau, Hendrik-Tobias, Porschen, Rainer, Koopman, Miriam, Punt, Cornelis J. A., Gramont, Aimery de, Tournigand, Christophe, Zeuzem, Stefan, and Trojan, Jörg
Abstract: Background: The aim of this meta-analysis was to evaluate efficacy and safety of first-line chemotherapy with or without a monoclonal antibody in elderly patients ( ≥ 70 years) with metastatic colorectal cancer (mCRC), since they are frequently underrepresented in clinical trials. Results: Individual data from 10 studies were included. From a total of 3271 patients, 604 patients (18%) were ≥ 70 years (median 73 years, range 70–88). Of these, 335 patients were treated with a bevacizumab-based first-line regimen and 265 were treated with chemotherapy only. The median PFS was 8.2 vs. 6.5 months and the median OS was 16.7 vs. 13.0 months in patients treated with and without bevacizumab, respectively. The safety profile of bevacizumab in combination with first-line chemotherapy did not differ from published clinical trials. Materials and Methods: PubMed and Cochrane Library searches were performed on 29 April 2013 and studies published to this date were included. Authors were contacted to request progression-free survival (PFS), overall survival (OS) data, patient data on treatment regimens, age, sex and potential signs of toxicity in patients ≥ 70 years of age. Conclusions: This meta-analysis suggests that the addition of bevacizumab to standard first-line chemotherapy improves clinical outcome in elderly patients with mCRC and is well tolerated.
Published: 2017

41. Clinical application of liquid biopsy in targeted therapy of metastatic colorectal cancer

Author: Trojan, Jörg, Klein-Scory, Susanne, Koch, Christine, Schmiegel, Wolff, Baraniskin, Alexander, Trojan, Jörg, Klein-Scory, Susanne, Koch, Christine, Schmiegel, Wolff, and Baraniskin, Alexander
Abstract: Background. Colorectal cancers (CRC) shed DNA into blood circulation. There is growing evidence that the analysis of circulating tumor DNA can be effectively used for monitoring of disease, to track tumor heterogeneity and to evaluate response to treatment. Case Presentation. Here, we describe two cases of patients with advanced CRC. The first case is about a patient with no available tissue for analysis of RAS mutation status. Liquid biopsy revealed RAS-wild-type and the therapy with anti-EGFR (epidermal growth factor receptor) monoclonal antibody cetuximab could be initiated. In the second case, the mutational profile of a patient with initial wild-type RAS-status was continually tracked during the course of treatment. An acquired KRAS exon 3 mutation was detected. The number of KRAS mutated fragments decreased continuously after the discontinuation of the therapy with EGFR-specific antibodies. Conclusion. Liquid biopsy provides a rapid genotype result, which accurately reproduces the current mutation status of tumor tissue. Furthermore, liquid biopsy enables close monitoring of the onset of secondary resistance to anti-EGFR therapy.
Published: 2017

42. Prognostic value of the neutrophil-to-lymphocyte ratio in the ARQ 197-215 second-line study for advanced hepatocellular carcinoma

Author: Personeni, Nicola, Giordano, Laura, Abbadessa, Giovanni, Porta, Camillo, Borbath, Ivan, Daniele, Bruno, Van Laethem, Jean Luc, Van Vlierberghe, Han, Trojan, Jörg, De Toni, Enrico N, Gasbarrini, Antonio, Lencioni, Monica, Lamar, Maria E, Wang, Yunxia, Shuster, Dale, Schwartz, Brian, Santoro, Armando, Rimassa, Lorenza, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Personeni, Nicola, Giordano, Laura, Abbadessa, Giovanni, Porta, Camillo, Borbath, Ivan, Daniele, Bruno, Van Laethem, Jean Luc, Van Vlierberghe, Han, Trojan, Jörg, De Toni, Enrico N, Gasbarrini, Antonio, Lencioni, Monica, Lamar, Maria E, Wang, Yunxia, Shuster, Dale, Schwartz, Brian, Santoro, Armando, Rimassa, Lorenza, and Gasbarrini, Antonio (ORCID:0000-0002-7278-4823)
Abstract: n/a
Published: 2017

43. Prognostic value of the neutrophil-to-lymphocyte ratio in the ARQ 197-215 second-line study for advanced hepatocellular carcinoma

Author: Personeni, Nicola, Giordano, Laura, Abbadessa, Giovanni, Porta, Camillo, Borbath, Ivan, Daniele, Bruno, Van Laethem, Jean Luc, Van Vlierberghe, Han, Trojan, Jörg, De Toni, Enrico N, Gasbarrini, Antonio, Lencioni, Monica, Lamar, Maria E, Wang, Yunxia, Shuster, Dale, Schwartz, Brian, Santoro, Armando, Rimassa, Lorenza, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Personeni, Nicola, Giordano, Laura, Abbadessa, Giovanni, Porta, Camillo, Borbath, Ivan, Daniele, Bruno, Van Laethem, Jean Luc, Van Vlierberghe, Han, Trojan, Jörg, De Toni, Enrico N, Gasbarrini, Antonio, Lencioni, Monica, Lamar, Maria E, Wang, Yunxia, Shuster, Dale, Schwartz, Brian, Santoro, Armando, Rimassa, Lorenza, and Gasbarrini, Antonio (ORCID:0000-0002-7278-4823)
Abstract: n/a
Published: 2017

44. Prognostic value of the neutrophil-to-lymphocyte ratio in the ARQ 197-215 second-line study for advanced hepatocellular carcinoma

Author: Personeni, Nicola, De Toni, Enrico E.N., Gasbarrini, Antonio, Lencioni, Monica, Lamar, Maria E, Wang, Yunxia, Shuster, Dale, Schwartz, Brian, Santoro, Armando, Rimassa, Lorenza, Giordano, Laura, Abbadessa, Giovanni, Porta, Camillo, Borbath, Ivan, Daniele, Bruno, Van Laethem, Jean-Luc, Van Vlierberghe, Hans, Trojan, Jörg, Personeni, Nicola, De Toni, Enrico E.N., Gasbarrini, Antonio, Lencioni, Monica, Lamar, Maria E, Wang, Yunxia, Shuster, Dale, Schwartz, Brian, Santoro, Armando, Rimassa, Lorenza, Giordano, Laura, Abbadessa, Giovanni, Porta, Camillo, Borbath, Ivan, Daniele, Bruno, Van Laethem, Jean-Luc, Van Vlierberghe, Hans, and Trojan, Jörg
Abstract: The ARQ 197-215 study randomized patients to tivantinib or placebo and prespecified efficacy analyses indicated the predictive value of MET expression as a marker of benefit from tivantinib in hepatocellular carcinoma (HCC). We aimed to explore the neutrophil-to-lymphocyte ratio (NLR) in 98 ARQ 197-215 patients with available absolute neutrophil count and absolute lymphocyte count at baseline. The cut-off value used to define high versus low NLR was 3.0. In univariate analysis, high NLR was associated with hazard ratio (HR) for overall survival (OS) of 1.58 [95% confidence interval (CI) 1.01; 2.47; P < 0.046], corresponding to median OS of 5.1 months versus 7.8 months in patients with low NLR (P = 0.044). In contrast, time to progression was not significantly affected by NLR (P = 0.20). Multivariable model confirmed that both NLR >3 (P = 0.03) and presence of vascular invasion (P = 0.017) were negatively associated with OS. After adjustment for vascular invasion, NLR independently predicted survival in both the placebo and the tivantinib cohort. For OS, no interaction was detected between NLR status and treatment (Pinteraction = 0.40). Baseline NLR is an independent prognostic biomarker in patients with HCC and compensated liver function who are candidate for second-line treatments., SCOPUS: ar.j, info:eu-repo/semantics/published
Published: 2017

45. Tumor and circulating biomarkers in patients with second-line hepatocellular carcinoma from the randomized phase II study with tivantinib.

Author: UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (SLuc) Service de gastro-entérologie, Rimassa, Lorenza, Abbadessa, Giovanni, Personeni, Nicola, Porta, Camillo, Borbath, Ivan, Daniele, Bruno, Salvagni, Stefania, Van Laethem, Jean-Luc, Van Vlierberghe, Hans, Trojan, Jörg, De Toni, Enrico N, Weiss, Alan, Miles, Steven, Gasbarrini, Antonio, Lencioni, Monica, Lamar, Maria E, Wang, Yunxia, Shuster, Dale, Schwartz, Brian E, Santoro, Armando, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (SLuc) Service de gastro-entérologie, Rimassa, Lorenza, Abbadessa, Giovanni, Personeni, Nicola, Porta, Camillo, Borbath, Ivan, Daniele, Bruno, Salvagni, Stefania, Van Laethem, Jean-Luc, Van Vlierberghe, Hans, Trojan, Jörg, De Toni, Enrico N, Weiss, Alan, Miles, Steven, Gasbarrini, Antonio, Lencioni, Monica, Lamar, Maria E, Wang, Yunxia, Shuster, Dale, Schwartz, Brian E, and Santoro, Armando
Abstract: ARQ 197-215 was a randomized placebo-controlled phase II study testing the MET inhibitor tivantinib in second-line hepatocellular carcinoma (HCC) patients. It identified tumor MET as a key biomarker in HCC. Aim of this research was to study the prognostic and predictive value of tumor (MET, the receptor tyrosine kinase encoded by the homonymous MNNG-HOS transforming gene) and circulating (MET, hepatocyte growth factor [HGF], alpha-fetoprotein [AFP], vascular endothelial growth factor [VEGF]) biomarkers in second-line HCC. Tumor MET-High status was centrally assessed by immunohistochemistry. Circulating biomarkers were centrally analyzed on serum samples collected at baseline and every 4-8 weeks, using medians as cut-off to determine High/Low status. Tumor MET, tested in 77 patients, was more frequently High after (82%) versus before (40%) sorafenib. A significant interaction (p = 0.04) between tivantinib and baseline tumor MET in terms of survival was observed. Baseline circulating MET and HGF (102 patients) High status correlated with shorter survival (HR 0.61, p = 0.03, and HR 0.60, p = 0.02, respectively), while the association between AFP (104 patients) or VEGF (103 patients) status and survival was non-significant.
Published: 2016

46. Krebs. Länger leben mit Immuntherapie : Checkpoint-Inhibitoren machen Krebszellen für das Immunsystem sichtbar

Author: Trojan, Jörg, Greten, Florian, Trojan, Jörg, and Greten, Florian
Abstract: Es war kein Aprilscherz, als das »Time Magazine« am 1. April 2013 auf der Titelseite ankündigte, wie man Krebs heilen kann. Anlass war die Gründung einer Initiative zur besseren Vernetzung von klinischen Forschern und Grundlagenwissenschaftlern, um so neue Therapieansätze wie »Checkpoint-Inhibitoren« bei malignem Melanom (schwarzem Hautkrebs), auch auf andere Krebserkrankungen übertragen zu können. Checkpoint-Inhibitoren sind der erste echte Durchbruch in der Therapie von fortgeschrittenen Krebserkrankungen.
Published: 2016

47. Tumor and circulating biomarkers in patients with second-line hepatocellular carcinoma from the randomized phase II study with tivantinib

Author: Rimassa, Lorenza, Abbadessa, Giovanni, Personeni, Nicola, Porta, Camillo, Borbath, Ivan, Daniele, Bruno, Salvagni, Stefania, Van Laethem, Jean Luc, Van Vlierberghe, Han, Trojan, Jörg, De Toni, Enrico N., Weiss, Alan, Miles, Steven, Gasbarrini, Antonio, Lencioni, Monica, Lamar, Maria E., Wang, Yunxia, Shuster, Dale, Schwartz, Brian E., Santoro, Armando, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Rimassa, Lorenza, Abbadessa, Giovanni, Personeni, Nicola, Porta, Camillo, Borbath, Ivan, Daniele, Bruno, Salvagni, Stefania, Van Laethem, Jean Luc, Van Vlierberghe, Han, Trojan, Jörg, De Toni, Enrico N., Weiss, Alan, Miles, Steven, Gasbarrini, Antonio, Lencioni, Monica, Lamar, Maria E., Wang, Yunxia, Shuster, Dale, Schwartz, Brian E., Santoro, Armando, and Gasbarrini, Antonio (ORCID:0000-0002-7278-4823)
Abstract: ARQ 197-215 was a randomized placebo-controlled phase II study testing the MET inhibitor tivantinib in second-line hepatocellular carcinoma (HCC) patients. It identified tumor MET as a key biomarker in HCC. Aim of this research was to study the prognostic and predictive value of tumor (MET, the receptor tyrosine kinase encoded by the homonymous MNNG-HOS transforming gene) and circulating (MET, hepatocyte growth factor [HGF], alpha-fetoprotein [AFP], vascular endothelial growth factor [VEGF]) biomarkers in second-line HCC. Tumor MET-High status was centrally assessed by immunohistochemistry. Circulating biomarkers were centrally analyzed on serum samples collected at baseline and every 4-8 weeks, using medians as cut-off to determine High/Low status. Tumor MET, tested in 77 patients, was more frequently High after (82%) versus before (40%) sorafenib. A significant interaction (p = 0.04) between tivantinib and baseline tumor MET in terms of survival was observed. Baseline circulating MET and HGF (102 patients) High status correlated with shorter survival (HR 0.61, p = 0.03, and HR 0.60, p = 0.02, respectively), while the association between AFP (104 patients) or VEGF (103 patients) status and survival was non-significant. Conclusions: Tumor MET levels were higher in patients treated with sorafenib. Circulating biomarkers such as MET and HGF may be prognostic in second-line HCC. These results need to be confirmed in larger randomized clinical trials.
Published: 2016

48. Tumor and circulating biomarkers in patients with second-line hepatocellular carcinoma from the randomized phase II study with tivantinib

Author: Rimassa, Lorenza, Trojan, Jörg, De Toni, Enrico E.N., Weiss, Alan, Miles, Steven, Gasbarrini, Antonio, Lencioni, Monica, Lamar, Maria E, Wang, Yunxia, Shuster, Dale, Schwartz, Brian, Abbadessa, Giovanni, Santoro, Armando, Personeni, Nicola, Porta, Camillo, Borbath, Ivan, Daniele, Bruno, Salvagni, Stefania, Van Laethem, Jean-Luc, Van Vlierberghe, Hans, Rimassa, Lorenza, Trojan, Jörg, De Toni, Enrico E.N., Weiss, Alan, Miles, Steven, Gasbarrini, Antonio, Lencioni, Monica, Lamar, Maria E, Wang, Yunxia, Shuster, Dale, Schwartz, Brian, Abbadessa, Giovanni, Santoro, Armando, Personeni, Nicola, Porta, Camillo, Borbath, Ivan, Daniele, Bruno, Salvagni, Stefania, Van Laethem, Jean-Luc, and Van Vlierberghe, Hans
Abstract: ARQ 197-215 was a randomized placebo-controlled phase II study testing the MET inhibitor tivantinib in second-line hepatocellular carcinoma (HCC) patients. It identified tumor MET as a key biomarker in HCC. Aim of this research was to study the prognostic and predictive value of tumor (MET, the receptor tyrosine kinase encoded by the homonymous MNNG-HOS transforming gene) and circulating (MET, hepatocyte growth factor [HGF], alpha-fetoprotein [AFP], vascular endothelial growth factor [VEGF]) biomarkers in second-line HCC. Tumor MET-High status was centrally assessed by immunohistochemistry. Circulating biomarkers were centrally analyzed on serum samples collected at baseline and every 4-8 weeks, using medians as cut-off to determine High/Low status. Tumor MET, tested in 77 patients, was more frequently High after (82%) versus before (40%) sorafenib. A significant interaction (p = 0.04) between tivantinib and baseline tumor MET in terms of survival was observed. Baseline circulating MET and HGF (102 patients) High status correlated with shorter survival (HR 0.61, p = 0.03, and HR 0.60, p = 0.02, respectively), while the association between AFP (104 patients) or VEGF (103 patients) status and survival was non-significant. Conclusions: Tumor MET levels were higher in patients treated with sorafenib. Circulating biomarkers such as MET and HGF may be prognostic in second-line HCC. These results need to be confirmed in larger randomized clinical trials., SCOPUS: ar.j, info:eu-repo/semantics/published
Published: 2016

49. Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma

Author: Scholz, Alexander, Harter, Patrick Nikolaus, Cremer, Sebastian, Yalcin, Burak H., Gurnik, Stefanie, Yamaji, Maiko, Di Tacchio, Mariangela, Sommer, Kathleen, Baumgarten, Peter, Bähr, Oliver, Steinbach, Joachim Peter, Trojan, Jörg, Glas, Martin, Herrlinger, Ulrich, Krex, Dietmar, Meinhardt, Matthias, Weyerbrock, Astrid, Timmer, Marco, Goldbrunner, Roland, Deckert, Martina, Braun, Christian, Schittenhelm, Jens, Früh, Jochen, Ullrich, Evelyn, Mittelbronn, Michel Guy André, Plate, Karl, Reiss, Yvonne, Scholz, Alexander, Harter, Patrick Nikolaus, Cremer, Sebastian, Yalcin, Burak H., Gurnik, Stefanie, Yamaji, Maiko, Di Tacchio, Mariangela, Sommer, Kathleen, Baumgarten, Peter, Bähr, Oliver, Steinbach, Joachim Peter, Trojan, Jörg, Glas, Martin, Herrlinger, Ulrich, Krex, Dietmar, Meinhardt, Matthias, Weyerbrock, Astrid, Timmer, Marco, Goldbrunner, Roland, Deckert, Martina, Braun, Christian, Schittenhelm, Jens, Früh, Jochen, Ullrich, Evelyn, Mittelbronn, Michel Guy André, Plate, Karl, and Reiss, Yvonne
Abstract: Glioblastoma multiforme (GBM) is treated by surgical resection followed by radiochemotherapy. Bevacizumab is commonly deployed for anti‐angiogenic therapy of recurrent GBM; however, innate immune cells have been identified as instigators of resistance to bevacizumab treatment. We identified angiopoietin‐2 (Ang‐2) as a potential target in both naive and bevacizumab‐treated glioblastoma. Ang‐2 expression was absent in normal human brain endothelium, while the highest Ang‐2 levels were observed in bevacizumab‐treated GBM. In a murine GBM model, VEGF blockade resulted in endothelial upregulation of Ang‐2, whereas the combined inhibition of VEGF and Ang‐2 leads to extended survival, decreased vascular permeability, depletion of tumor‐associated macrophages, improved pericyte coverage, and increased numbers of intratumoral T lymphocytes. CD206+ (M2‐like) macrophages were identified as potential novel targets following anti‐angiogenic therapy. Our findings imply a novel role for endothelial cells in therapy resistance and identify endothelial cell/myeloid cell crosstalk mediated by Ang‐2 as a potential resistance mechanism. Therefore, combining VEGF blockade with inhibition of Ang‐2 may potentially overcome resistance to bevacizumab therapy.
Published: 2015

50. Panitumumab use in metastatic colorectal cancer and patterns of KRAS testing : results from a Europe-wide physician survey and medical records review

Author: Trojan, Jörg, Mineur, Laurent, Tomášek, Jiří, Rouleau, Etienne, Fabian, Pavel, Maglio, Giovanna de, García-Alfonso, Pilar, Aprile, Giuseppe, Taylor, Aliki, Kafatos, George, Downey, Gerald, Terwey, Jan-Henrik, Krieken, Joannes H. van, Trojan, Jörg, Mineur, Laurent, Tomášek, Jiří, Rouleau, Etienne, Fabian, Pavel, Maglio, Giovanna de, García-Alfonso, Pilar, Aprile, Giuseppe, Taylor, Aliki, Kafatos, George, Downey, Gerald, Terwey, Jan-Henrik, and Krieken, Joannes H. van
Abstract: Background: From 2008–2013, the European indication for panitumumab required that patients' tumor KRAS exon 2 mutation status was known prior to starting treatment. To evaluate physician awareness of panitumumab prescribing information and how physicians prescribe panitumumab in patients with metastatic colorectal cancer (mCRC), two European multi-country, cross-sectional, observational studies were initiated in 2012: a physician survey and a medical records review. The first two out of three planned rounds for each study are reported. Methods: The primary objective in the physician survey was to estimate the prevalence of KRAS testing, and in the medical records review, it was to evaluate the effect of test results on patterns of panitumumab use. The medical records review study also included a pathologists' survey. Results: In the physician survey, nearly all oncologists (299/301) were aware of the correct panitumumab indication and the need to test patients' tumor KRAS status before treatment with panitumumab. Nearly all oncologists (283/301) had in the past 6 months of clinical practice administered panitumumab correctly to mCRC patients with wild-type KRAS status. In the medical records review, 97.5% of participating oncologists (77/79) conducted a KRAS test for all of their patients prior to prescribing panitumumab. Four patients (1.3%) did not have tumor KRAS mutation status tested prior to starting panitumumab treatment. Approximately one-quarter of patients (85/306) were treated with panitumumab and concurrent oxaliplatin-containing chemotherapy; of these, 83/85 had confirmed wild-type KRAS status prior to starting panitumumab treatment. All 56 referred laboratories that participated used a Conformité Européenne-marked or otherwise validated KRAS detection method, and nearly all (55/56) participated in a quality assurance scheme. Conclusions: There was a high level of knowledge amongst oncologists around panitumumab prescribing information and the need to t
Published: 2015

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