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23 results on '"Tolba, R."'

5. Characterization of blunt chest trauma in a long-term porcine model of severe multiple trauma

Author

Horst, K, Simon, T P, Pfeifer, R, Teuben, M, Almahmoud, K, Zhi, Q, Santos, S Aguiar, Wembers, C Castelar, Leonhardt, S, Heussen, N, Störmann, P, Auner, B, Relja, B, Marzi, I, Haug, A T, van Griensven, M, Kalbitz, M, Huber-Lang, M, Tolba, R, Reiss, L K, Uhlig, S, Marx, G, Pape, Hans-Christoph, Hildebrand, Frank; https://orcid.org/0000-0001-7729-9838, Horst, K, Simon, T P, Pfeifer, R, Teuben, M, Almahmoud, K, Zhi, Q, Santos, S Aguiar, Wembers, C Castelar, Leonhardt, S, Heussen, N, Störmann, P, Auner, B, Relja, B, Marzi, I, Haug, A T, van Griensven, M, Kalbitz, M, Huber-Lang, M, Tolba, R, Reiss, L K, Uhlig, S, Marx, G, Pape, Hans-Christoph, and Hildebrand, Frank; https://orcid.org/0000-0001-7729-9838

Abstract

Chest trauma has a significant relevance on outcome after severe trauma. Clinically, impaired lung function typically occurs within 72 hours after trauma. However, the underlying pathophysiological mechanisms are still not fully elucidated. Therefore, we aimed to establish an experimental long-term model to investigate physiological, morphologic and inflammatory changes, after severe trauma. Male pigs (sus scrofa) sustained severe trauma (including unilateral chest trauma, femur fracture, liver laceration and hemorrhagic shock). Additionally, non-injured animals served as sham controls. Chest trauma resulted in severe lung damage on both CT and histological analyses. Furthermore, severe inflammation with a systemic increase of IL-6 (p = 0.0305) and a local increase of IL-8 in BAL (p = 0.0009) was observed. The pO2/FiO2 ratio in trauma animals decreased over the observation period (p < 0.0001) but not in the sham group (p = 0.2967). Electrical Impedance Tomography (EIT) revealed differences between the traumatized and healthy lung (p < 0.0001). In conclusion, a clinically relevant, long-term model of blunt chest trauma with concomitant injuries has been developed. This reproducible model allows to examine local and systemic consequences of trauma and is valid for investigation of potential diagnostic or therapeutic options. In this context, EIT might represent a radiation-free method for bedside diagnostics.

Published
2016

10. Motor outcome and allodynia are largely unaffected by novel olfactory ensheathing cell grafts to repair low-thoracic lesion gaps in the adult rat spinal cord.

Author

UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, Deumens, Ronald, Van Gorp, S F J, Bozkurt, A, Beckmann, C, Führmann, T, Montzka, K, Tolba, R, Kobayashi, E, Heschel, I, Weis, J, Brook, G A, UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, Deumens, Ronald, Van Gorp, S F J, Bozkurt, A, Beckmann, C, Führmann, T, Montzka, K, Tolba, R, Kobayashi, E, Heschel, I, Weis, J, and Brook, G A

Abstract

Olfactory ensheathing cells (OEC) are a promising graftable cell population for improving functional outcomes after experimental spinal cord injury. However only few studies have focused on experimental models with large cavitations, which require bridging substrates to transfer and maintain the donor cells within the lesion site. Here, a state-of-the-art collagen-based multi-channeled three dimensional scaffold was used to deliver olfactory ensheathing cells to 2 mm long unilateral low-thoracic hemisection cavities. For a period of 10 weeks, allodynia of the hindpaws was monitored using the von Frey hair filament test, while an extensive analysis of motor ability was performed with use of the CatWalk gait analysis system and the BBB locomotor scale. No substantial improvement or deterioration of motor functions was induced and there was no effect on lesion-induced allodynia. On the basis of these data, we conclude that relatively large spinal cord lesions with cavitation may present additional hurdles to the therapeutic effect of OEC. Future studies are needed to address the nature that such lesion cavities place on cell grafts.

Published
2013

13. Einsatz von olfaktorischen Gliazellen zur Regeneration peripherer Nerven

Author

Bozkurt, A, Brook, GA, mon O'Dey, D, Boecker, A, Tank, J, Möllers, S, Schügner, F, Heschel, I, van Neerven, S, Tolba, R, Pallua, N, Bozkurt, A, Brook, GA, mon O'Dey, D, Boecker, A, Tank, J, Möllers, S, Schügner, F, Heschel, I, van Neerven, S, Tolba, R, and Pallua, N

Published
2011

15. Einsatz von olfaktorischen Gliazellen zur Regeneration peripherer Nerven

Author

Bozkurt, A, Brook, GA, mon O'Dey, D, Boecker, A, Tank, J, Möllers, S, Schügner, F, Heschel, I, van Neerven, S, Tolba, R, Pallua, N, Bozkurt, A, Brook, GA, mon O'Dey, D, Boecker, A, Tank, J, Möllers, S, Schügner, F, Heschel, I, van Neerven, S, Tolba, R, and Pallua, N

Published
2011

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