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14 results on '"Tinnemans, Paul"'

4. Combining Diastereomeric Resolution and Viedma Ripening by Using a Racemic Resolving Agent

Author

Lerdwiriyanupap, Tharit, Belletti, Giuseppe, Tinnemans, Paul, Meekes, H.L.M., Rutjes, Floris P.J.T., Vlieg, E., Flood, Adrian E., Lerdwiriyanupap, Tharit, Belletti, Giuseppe, Tinnemans, Paul, Meekes, H.L.M., Rutjes, Floris P.J.T., Vlieg, E., and Flood, Adrian E.

Abstract

Contains fulltext : 241061.pdf (Publisher’s version ) (Open Access)

Published
2021

6. Combining Diastereomeric Resolution and Viedma Ripening by Using a Racemic Resolving Agent

Author

Lerdwiriyanupap, Tharit, Belletti, Giuseppe, Tinnemans, Paul, Meekes, H.L.M., Rutjes, Floris P.J.T., Vlieg, E., Flood, Adrian E., Lerdwiriyanupap, Tharit, Belletti, Giuseppe, Tinnemans, Paul, Meekes, H.L.M., Rutjes, Floris P.J.T., Vlieg, E., and Flood, Adrian E.

Abstract

Contains fulltext : 241061.pdf (Publisher’s version ) (Open Access)

Published
2021

9. Nanoparticles for “two color” 19F magnetic resonance imaging: Towards combined imaging of biodistribution and degradation

Author

Koshkina, Olga, White, Paul B., Staal, Alexander H.J., Schweins, Ralf, Swider, Edyta, Tirotta, Ilaria, Tinnemans, Paul, Fokkink, Remco, Veltien, Andor, van Riessen, N.K., van Eck, Ernst R.H., Heerschap, Arend, Metrangolo, Pierangelo, Baldelli Bombelli, Francesca, Srinivas, Mangala, Koshkina, Olga, White, Paul B., Staal, Alexander H.J., Schweins, Ralf, Swider, Edyta, Tirotta, Ilaria, Tinnemans, Paul, Fokkink, Remco, Veltien, Andor, van Riessen, N.K., van Eck, Ernst R.H., Heerschap, Arend, Metrangolo, Pierangelo, Baldelli Bombelli, Francesca, and Srinivas, Mangala

Abstract

The use of polymeric nanoparticles (NPs) as therapeutics has been steadily increasing over past decades. In vivo imaging of NPs is necessary to advance the therapeutic performance. 19F Magnetic Resonance Imaging (19F MRI) offers multiple advantages for in vivo imaging. However, design of a probe for both biodistribution and degradation has not been realized yet. We developed polymeric NPs loaded with two fluorocarbons as promising imaging tools to monitor NP biodistribution and degradation by 19F MRI. These 200 nm NPs consist of poly(lactic-co-glycolic acid) (PLGA) loaded with perfluoro-15-crown-5 ether (PFCE) and PERFECTA. PERFECTA/PFCE-PLGA NPs have a fractal sphere structure, in which both fluorocarbons are distributed in the polymeric matrix of the fractal building blocks, which differs from PFCE-PLGA NPs and is unique for fluorocarbon-loaded colloids. This structure leads to changes of magnetic resonance properties of both fluorocarbons after hydrolysis of NPs. PERFECTA/PFCE-PLGA NPs are colloidally stable in serum and biocompatible. Both fluorocarbons show a single resonance in 19F MRI that can be imaged separately using different excitation pulses. In the future, these findings may be used for biodistribution and degradation studies of NPs by 19F MRI in vivo using “two color” labeling leading to improvement of drug delivery agents.

Published
2020

10. Photoracemization-Based Viedma Ripening of a BINOL Derivative

Author

Belletti, Giuseppe, Tortora, Carola, Mellema, Indradevi D., Tinnemans, Paul, Meekes, H.L.M., Rutjes, Floris P.J.T., Tsogoeva, Svetlana B., Vlieg, E., Belletti, Giuseppe, Tortora, Carola, Mellema, Indradevi D., Tinnemans, Paul, Meekes, H.L.M., Rutjes, Floris P.J.T., Tsogoeva, Svetlana B., and Vlieg, E.

Abstract

Contains fulltext : 214406.pdf (publisher's version ) (Open Access)

Published
2019

11. Cocrystal design by network-based link prediction

Author

Devogelaer, Jan-Joris, Brugman, S.J.T., Meekes, H.L.M., Tinnemans, Paul, Vlieg, E., Gelder, Rene de, Devogelaer, Jan-Joris, Brugman, S.J.T., Meekes, H.L.M., Tinnemans, Paul, Vlieg, E., and Gelder, Rene de

Abstract

Contains fulltext : 214377.pdf (publisher's version ) (Open Access)

Published
2019

12. Photoracemization-Based Viedma Ripening of a BINOL Derivative

Author

Belletti, Giuseppe, Tortora, Carola, Mellema, Indradevi D., Tinnemans, Paul, Meekes, H.L.M., Rutjes, Floris P.J.T., Tsogoeva, Svetlana B., Vlieg, E., Belletti, Giuseppe, Tortora, Carola, Mellema, Indradevi D., Tinnemans, Paul, Meekes, H.L.M., Rutjes, Floris P.J.T., Tsogoeva, Svetlana B., and Vlieg, E.

Abstract

Contains fulltext : 214406.pdf (publisher's version ) (Open Access)

Published
2019

13. Cocrystal design by network-based link prediction

Author

Devogelaer, Jan-Joris, Brugman, S.J.T., Meekes, H.L.M., Tinnemans, Paul, Vlieg, E., Gelder, Rene de, Devogelaer, Jan-Joris, Brugman, S.J.T., Meekes, H.L.M., Tinnemans, Paul, Vlieg, E., and Gelder, Rene de

Abstract

Contains fulltext : 214377.pdf (publisher's version ) (Open Access)

Published
2019

14. Cocrystal design by network-based link prediction

Author

Devogelaer, Jan-Joris, Brugman, S.J.T., Meekes, H.L.M., Tinnemans, Paul, Vlieg, E., Gelder, Rene de, Devogelaer, Jan-Joris, Brugman, S.J.T., Meekes, H.L.M., Tinnemans, Paul, Vlieg, E., and Gelder, Rene de

Abstract

Contains fulltext : 214377.pdf (publisher's version ) (Open Access)

Published
2019

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