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1. Association of fatal myocardial infarction with past level of physical activity: a pooled analysis of cohort studies

Author

Hansen, K.W. Peytz, N. Blokstra, A. Bojesen, S.E. Celis-Morales, C. Chrysohoou, C. Clays, E. De Bacquer, D. Galatius, S. Gray, S.R. Ho, F. Kavousi, M. Koolhaas, C.M. Kouvari, M. Løchen, M.-L. Marques-Vidal, P. Osler, M. Panagiotakos, D. Pell, J.P. Sulo, G. Tell, G.S. Vassiliou, V. Verschuren, W.M.M. Prescott, E. and Hansen, K.W. Peytz, N. Blokstra, A. Bojesen, S.E. Celis-Morales, C. Chrysohoou, C. Clays, E. De Bacquer, D. Galatius, S. Gray, S.R. Ho, F. Kavousi, M. Koolhaas, C.M. Kouvari, M. Løchen, M.-L. Marques-Vidal, P. Osler, M. Panagiotakos, D. Pell, J.P. Sulo, G. Tell, G.S. Vassiliou, V. Verschuren, W.M.M. Prescott, E.

Abstract

AIMS: To assess the association between past level of physical activity (PA) and risk for death during the acute phase of myocardial infarction (MI) in a pooled analysis of cohort studies. METHODS AND RESULTS: European cohorts including participants with a baseline assessment of PA, conventional cardiovascular (CV) risk factors, and available follow-up on MI and death were eligible. Patients with an incident MI were included. Leisure-time PA was grouped as sedentary (<7 MET-hours), low (7-16 MET-hours), moderate (16.1-32 MET-hours), or high (>32 MET-hours) based on calculated net weekly energy expenditure. The main outcome measures were instant and 28-day case fatality of MI. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using multivariate random-effects models. Adjustments for age, sex, CV risk factors, alcohol consumption, and socioeconomic status were made. From 10 cohorts including a total of 1 495 254 participants, 28 140 patients with an incident MI comprised the study population. A total of 4976 (17.7%) died within 28 days-of these 3101 (62.3%) were classified as instant fatal MI. Compared with sedentary individuals, those with a higher level of PA had lower adjusted odds of instant fatal MI: low PA [OR, 0.79 (95% CI, 0.60-1.04)], moderate PA [0.67 (0.51-0.89)], and high PA [0.55 (0.40-0.76)]. Similar results were found for 28-day fatal MI: low PA [0.85 (0.71-1.03)], moderate PA [0.64 (0.51-0.80)], and high PA [0.72 (0.51-1.00)]. A low-to-moderate degree of heterogeneity was detected in the analysis of instant fatal MI (I2 = 47.3%), but not in that of 28-day fatal MI (I2 = 0.0%). CONCLUSION: A moderate-to-high level of PA was associated with a lower risk of instant and 28-day death in relation to a MI. © The Author(s) 2021. Published on behalf of the European Society of Cardiology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Published
2021

2. Association of markers of inflammation, the kynurenine pathway and B vitamins with age and mortality, and a signature of inflammaging.

Author

Dugue P.-A., Hodge A.M., Ulvik A., Ueland P.M., Midttun O., Rinaldi S., Macinnis R.J., Li S.X., Meyer K., Navionis A.-S., Flicker L., Severi G., English D.R., Vineis P., Tell G.S., Southey M.C., Milne R.L., Giles G.G., Dugue P.-A., Hodge A.M., Ulvik A., Ueland P.M., Midttun O., Rinaldi S., Macinnis R.J., Li S.X., Meyer K., Navionis A.-S., Flicker L., Severi G., English D.R., Vineis P., Tell G.S., Southey M.C., Milne R.L., and Giles G.G.

Abstract

BACKGROUND: Inflammation is a key feature of aging. We aimed to i) investigate the association of 34 blood markers potentially involved in inflammatory processes with age and mortality, ii) develop a signature of 'inflammaging'. METHOD(S): Thirty-four blood markers relating to inflammation, B vitamin status and the kynurenine pathway were measured in 976 participants in the Melbourne Collaborative Cohort Study at baseline (median age=59 years) and follow-up (median age=70 years). Associations with age and mortality were assessed using linear and Cox regression, respectively. A parsimonious signature of inflammaging was developed and its association with mortality was compared with two marker scores calculated across all markers associated with age and mortality, respectively. RESULT(S): The majority of markers (30/34) were associated with age, with stronger associations observed for neopterin, cystatin C, IL-6, TNF-alpha, several markers of the kynurenine pathway and derived indices KTR (kynurenine/tryptophan ratio), PAr index (ratio of 4-pyridoxic acid and the sum of pyridoxal 5'-phosphate and pyridoxal), and HK:XA (3-hydroxykynurenine/xanthurenic acid ratio). Many markers (17/34) showed an association with mortality, in particular IL-6, neopterin, CRP, quinolinic acid, PAr index, and KTR. The inflammaging signature included ten markers and was strongly associated of mortality (HR per SD=1.40, 95%CI:1.24-1.57, P=2x10 -8), similar to scores based on all age-associated (HR=1.38, 95%CI:1.23-1.55, P=4x10 -8) and mortality-associated markers (HR=1.43, 95%CI:1.28-1.60, P=1x10 -10), respectively. Strong evidence of replication of the inflammaging signature association with mortality was found in the Hordaland Health Study. CONCLUSION(S): Our study highlights the key role of the kynurenine pathway and vitamin B6 catabolism in aging, along with other well-established inflammation-related markers. A signature of inflammaging based on ten markers was strongly associated with

Published
2021

3. Association of markers of inflammation, the kynurenine pathway and B vitamins with age and mortality, and a signature of inflammaging.

Author

Dugue P.-A., Hodge A.M., Ulvik A., Ueland P.M., Midttun O., Rinaldi S., Macinnis R.J., Li S.X., Meyer K., Navionis A.-S., Flicker L., Severi G., English D.R., Vineis P., Tell G.S., Southey M.C., Milne R.L., Giles G.G., Dugue P.-A., Hodge A.M., Ulvik A., Ueland P.M., Midttun O., Rinaldi S., Macinnis R.J., Li S.X., Meyer K., Navionis A.-S., Flicker L., Severi G., English D.R., Vineis P., Tell G.S., Southey M.C., Milne R.L., and Giles G.G.

Abstract

BACKGROUND: Inflammation is a key feature of aging. We aimed to i) investigate the association of 34 blood markers potentially involved in inflammatory processes with age and mortality, ii) develop a signature of 'inflammaging'. METHOD(S): Thirty-four blood markers relating to inflammation, B vitamin status and the kynurenine pathway were measured in 976 participants in the Melbourne Collaborative Cohort Study at baseline (median age=59 years) and follow-up (median age=70 years). Associations with age and mortality were assessed using linear and Cox regression, respectively. A parsimonious signature of inflammaging was developed and its association with mortality was compared with two marker scores calculated across all markers associated with age and mortality, respectively. RESULT(S): The majority of markers (30/34) were associated with age, with stronger associations observed for neopterin, cystatin C, IL-6, TNF-alpha, several markers of the kynurenine pathway and derived indices KTR (kynurenine/tryptophan ratio), PAr index (ratio of 4-pyridoxic acid and the sum of pyridoxal 5'-phosphate and pyridoxal), and HK:XA (3-hydroxykynurenine/xanthurenic acid ratio). Many markers (17/34) showed an association with mortality, in particular IL-6, neopterin, CRP, quinolinic acid, PAr index, and KTR. The inflammaging signature included ten markers and was strongly associated of mortality (HR per SD=1.40, 95%CI:1.24-1.57, P=2x10 -8), similar to scores based on all age-associated (HR=1.38, 95%CI:1.23-1.55, P=4x10 -8) and mortality-associated markers (HR=1.43, 95%CI:1.28-1.60, P=1x10 -10), respectively. Strong evidence of replication of the inflammaging signature association with mortality was found in the Hordaland Health Study. CONCLUSION(S): Our study highlights the key role of the kynurenine pathway and vitamin B6 catabolism in aging, along with other well-established inflammation-related markers. A signature of inflammaging based on ten markers was strongly associated with

Published
2021

4. Repositioning of the global epicentre of non-optimal cholesterol

Author

Taddei, C. (Cristina), Zhou, B. (Bin), Bixby, H. (Honor), Carrillo-Larco, R.M. (Rodrigo M.), Danaei, G. (Goodarz), Jackson, R.T. (Rod T.), Farzadfar, F. (Farshad), Sophiea, M.K. (Marisa K.), Di Cesare, M. (Mariachiara), Iurilli, M.L.C. (Maria Laura Caminia), Martinez, A.R. (Andrea Rodriguez), Asghari, G. (Golaleh), Dhana, K. (Klodian), Gulayin, P. (Pablo), Kakarmath, S. (Sujay), Santero, M. (Marilina), Voortman, R.G. (Trudy), Riley, L.M. (Leanne M.), Cowan, M.J. (Melanie J.), Savin, S. (Stefan), Bennett, J.E. (James E.), Stevens, G.A. (Gretchen A.), Paciorek, C.J. (Christopher J.), Aekplakorn, W. (Wichai), Cifkova, R. (Renata), Giampaoli, S. (Simona), Kengne, A.P. (Andre Pascal), Khang, Y.-H. (Young-Ho), Kuulasmaa, K. (Kari), Laxmaiah, A. (Avula), Margozzini, P. (Paula), Mathur, P. (Prashant), Nordestgaard, B.G. (Børge), Zhao, D. (Dong), Aadahl, M. (Mette), Abarca-Gómez, L. (Leandra), Rahim, H.A. (Hanan Abdul), Abu-Rmeileh, N.M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R.J. (Robert J.), Agdeppa, I.A. (Imelda A.), Aghazadeh-Attari, J. (Javad), Aguilar-Salinas, C.A. (Carlos A.), Agyemang, C.O. (Charles), Ahluwalia, T.S. (Tarunveer Singh), Ahmad, N.A. (Noor Ani), Ahmadi, A. (Ali), Ahmadi, N. (Naser), Ahmed, S.H. (Soheir H.), Ahrens, W. (W.), Ajlouni, K. (Kamel), Alarouj, M. (Monira), AlBuhairan, F. (Fadia), AlDhukair, S. (Shahla), Ali, M.M. (Mohamed M.), Alkandari, A. (Abdullah), Alkerwi, A. (Ala’a), Aly, E. (Eman), Amarapurkar, D.N. (Deepak N.), Amouyel, P. (Philippe), Andersen, L.B. (Lars Bo), Anderssen, S.A. (Sigmund A.), Anjana, R.M. (Ranjit Mohan), Ansari-Moghaddam, A. (Alireza), Aounallah-Skhiri, H. (Hajer), Araújo, J. (Joana), Ariansen, I. (Inger), Aris, T. (Tahir), Arku, R.E. (Raphael E.), Arlappa, N. (Nimmathota), Aryal, K.K. (Krishna K.), Aspelund, T. (Thor), Assunção, M.C.F. (Maria Cecília F.), Auvinen, J. (Juha), Avdicová, M. (Mária), Azevedo, A. (Ana), Azizi, J. (Joshan), Azmin, M. (Mehrdad), Balakrishna, N. (Nagalla), Bamoshmoosh, M. (Mohamed), Banach, M. (Maciej), Bandosz, P. (Piotr), Banegas, J.R. (José R.), Barbagallo, C.M. (Carlo M.), Barceló, A. (Alberto), Barkat, A. (Amina), Bata, I. (Iqbal), Batieha, A.M. (Anwar M.), Batyrbek, A. (Assembekov), Baur, L.A. (Louise A.), Beaglehole, R. (Robert), Belavendra, A. (Antonisamy), Ben Romdhane, H. (Habiba), Benet, M. (Mikhail), Benn, M. (Marianne), Berkinbayev, S. (Salim), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhargava, S.K. (Santosh K.), Bi, Y. (Yufang), Bienek, A. (Asako), Bikbov, M. (Mukharram), Bista, B. (Bihungum), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjertness, M.B. (Marius B.), Björkelund, C. (Cecilia), Bloch, K.V. (Katia V.), Blokstra, A. (Anneke), Bo, S. (Simona), Boehm, B.O. (Bernhard O.), Boggia, J.G. (Jose G.), Boissonnet, C.P. (Carlos P.), Bonaccio, M. (Marialaura), Bongard, V. (Vanina), Borchini, R. (Rossana), Borghs, H. (Herman), Bovet, P. (Pascal), Brajkovich, I. (Imperia), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L.M. (Lizzy), Bruno, G. (Graziella), Bugge, A. (Anna), Busch, M.A. (Markus A.), de León, A.C. (Antonio Cabrera), Cacciottolo, J. (Joseph), Can, G. (Günay), Cândido, A.P.C. (Ana Paula C.), Capanzana, M.V. (Mario V.), Capuano, E. (Eduardo), Capuano, V. (Vincenzo), Cardoso, V.C. (Viviane C.), Carvalho, J. (Joana), Casanueva, F.F., Censi, L. (Laura), Chadjigeorgiou, C.A. (Charalambos A.), Chamukuttan, S. (Snehalatha), Chaturvedi, N. (Nish), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, S. (Shuohua), Cheng, C.-Y. (Ching-Yu), Cheraghian, B. (Bahman), Chetrit, A. (Angela), Chiou, S.-T. (Shu-Ti), Chirlaque, M.D. (M.), Cho, B. (Belong), Cho, Y. (Yumi), Chudek, J. (Jerzy), Claessens, F. (Frank), Clarke, J. (Janine), Clays, E. (Els), Concin, H. (Hans), Confortin, S.C. (Susana C.), Cooper, C. (Charles), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Crujeiras, A.B. (Ana B.), Csilla, S. (Semánová), Cui, L. (Liufu), Cureau, F.V. (Felipe V.), D’Arrigo, G. (Graziella), d’Orsi, E. (Eleonora), Dallongeville, J., Damasceno, A. (Albertino), Dankner, R. (Rachel), Dantoft, T.M. (Thomas M.), Dauchet, L. (Luc), Davletov, K. (Kairat), Backer, G. (Guy) de, Bacquer, D. (Dirk) de, de Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), de Oliveira, P.D. (Paula Duarte), De Ridder, D. (David), De Smedt, D. (Delphine), Deepa, M. (Mohan), Deev, A.D. (Alexander D.), Dehghan, A. (Abbas), Delisle, H. (Hélène), Dennison, E.M. (Elaine), Deschamps, V. (Valérie), Dhimal, M. (Meghnath), Di Castelnuovo, A.F. (Augusto F.), Dika, Z. (Zivka), Djalalinia, S. (Shirin), Dobson, A.J. (Annette J.), Donfrancesco, C. (Chiara), Donoso, S.P. (Silvana P.), Döring, A. (Angela), Dorobantu, M. (Maria), Dragano, N. (Nico), Drygas, W. (Wojciech), Du, Y. (Yong), Duante, C.A. (Charmaine A.), Duda, R.B. (Rosemary B.), Dzerve, V. (Vilnis), Dziankowska-Zaborszczyk, E. (Elzbieta), Eddie, R. (Ricky), Eftekhar, E. (Ebrahim), Eggertsen, R. (Robert), Eghtesad, S. (Sareh), Eiben, G. (Gabriele), Ekelund, U. (Ulf), El Ati, J. (Jalila), Eldemire-Shearer, D. (Denise), Eliasen, M. (Marie), Elosua, R. (Roberto), Erasmus, R.T. (Rajiv T.), Erbel, R. (Raimund), Erem, C. (Cihangir), Eriksen, L. (Louise), Hagen, K. (Knut), Escobedo-de la Peña, J. (Jorge), Eslami, S. (Saeid), Esmaeili, A. (Ali), Evans, A. (Alun), Faeh, D. (David), Fall, C.H. (Caroline H.), Faramarzi, E. (Elnaz), Farjam, M. (Mojtaba), Fattahi, M.R. (Mohammad Reza), Felix-Redondo, F.J. (Francisco J.), Ferguson, T.S. (Trevor S.), Fernández-Bergés, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Föger, B. (Bernhard), Foo, L.H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Forsner, M. (Maria), Fouad, H.M. (Heba M.), Francis, D.K. (Damian K.), do Carmo Franco, M. (Maria), Franco, O.H. (Oscar H.), Frontera, G. (Guillermo), Fujita, Y. (Yuki), Fumihiko, M. (Matsuda), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Galvano, F. (Fabio), Gao, J. (Jingli), Garcia-de-la-Hera, M. (Manoli), Garnett, S.P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gazzinelli, A. (Andrea), Geleijnse, J.M. (Marianne), Ghanbari, A. (Ali), Ghasemi, E. (Erfan), Gheorghe-Fronea, O.-F. (Oana-Florentina), Ghimire, A. (Anup), Gianfagna, F. (Francesco), Gill, T.K. (Tiffany K.), Giovannelli, J. (Jonathan), Gironella, G. (Glen), Giwercman, A. (Aleksander), Goltzman, D. (David), Gonçalves, H. (Helen), Gonzalez-Chica, D.A. (David A.), Gonzalez-Gross, M. (Marcela), González-Rivas, J.P. (Juan P.), González-Villalpando, C. (Clicerio), González-Villalpando, M.E. (María Elena), Gonzalez, A.R. (Angel R.), Gottrand, F., Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dušan), Gregor, R.D. (Ronald D.), Grodzicki, T. (Tomasz), Grøntved, A. (Anders), Grosso, G. (Giuseppe), Gruden, G. (Gabriella), Gu, D. (Dongfeng), Guallar-castillón, P. (Pilar), Guan, O.P. (Ong Peng), Gudmundsson, E.F. (Elias F.), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Gunnlaugsdottir, J. (Johanna), Gupta, R. (Rajeev), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Ha, S. (Seongjun), Hadaegh, F. (Farzad), Haghshenas, R. (Rosa), Hakimi, H. (Hamid), Hambleton, I.R. (Ian R.), Hamzeh, B. (Behrooz), Hantunen, S. (Sari), Kumar, R.H. (Rachakulla Hari), Hashemi-Shahri, S.M. (Seyed Mohammad), Hata, J. (Jun), Haugsgjerd, T. (Teresa), Hayes, A.J. (Alison J.), He, J. (Jiang), He, Y. (Yong), Hendriks, M.E. (Marleen), Henriques, A. (Ana), Herrala, S. (Sauli), Heshmat, R. (Ramin), Hill, A.G. (Allan G.), Ho, S.Y. (Sai Yin), Ho, S.C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Homayounfar, R. (Reza), Hopman, W.M. (Wilma M.), Horimoto, A.R.V.R. (Andrea R. V. R.), Hormiga, C.M. (Claudia M.), Horta, B.L. (Bernardo L.), Houti, L. (Leila), Howitt, C. (Christina), Htay, T.T. (Thein Thein), Htet, A.S. (Aung Soe), Htike, M.M.T. (Maung Maung Than), Huerta, J.M. (José María), Huhtaniemi, I.T. (I.), Huisman, M. (Martijn), Hunsberger, M.L. (Monica L.), Husseini, A. (Abdullatif), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A.G. (Anna G.), Ibrahim, M.M. (Mohsen), Wong, N.I. (Norazizah Ibrahim), Iglesia, I. (Iris), Ikeda, N. (Nayu), Ikram, M.A. (Arfan), Iotova, V. (Violeta), Irazola, V.E. (Vilma E.), Ishida, T. (Takafumi), Islam, M. (Muhammad), al-Safi Ismail, A. (Aziz), Iwasaki, M. (Masanori), Jacobs, J.M. (Jeremy M.), Jaddou, H.Y. (Hashem Y.), Jafar, T.H. (Tazeen), James, K. (Kenneth), Jamrozik, K., Janszky, I. (Imre), Janus, E. (Edward), Jarvelin, M.-R. (Marjo-Riitta), Jasienska, G. (Grazyna), Jelakovic, A. (Ana), Jelakovic, B. (Bojan), Jennings, G. (Garry), Jensen, G.B. (Gorm), Jeong, S.-L. (Seung-lyeal), Jha, A.K. (Anjani Kumar), Jiang, C.Q. (Chao Qiang), Jimenez, R.O. (Ramon O.), JöCkel, K.-H. (Karl-Heinz), Joffres, M. (Michel), Jokelainen, J.J. (Jari J.), Jonas, J.B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Joukar, F. (Farahnaz), Józwiak, J. (Jacek), Juolevi, A. (Anne), Kafatos, A. (Anthony), Kajantie, E. (Eero), Kalter-Leibovici, O. (Ofra), Kamaruddin, N.A. (Nor Azmi), Kamstrup, P.R. (Pia R.), Karki, K.B. (Khem B.), Katz, J. (Joanne), Kauhanen, J. (Jussi), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Kazakbaeva, G. (Gyulli), Keil, M. (Mark), Keinanen-Kiukaanniemi, S. (Sirkka), Kelishadi, R. (Roya), Keramati, M. (Maryam), Kerimkulova, A. (Alina), Kersting, M. (Mathilde), Khader, Y.S. (Yousef Saleh), Khalili, D. (Davood), Khateeb, M. (Mohammad), Kheradmand, M. (Motahareh), Khosravi, A. (Alireza), Kiechl-Kohlendorfer, U. (Ursula), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, H.C. (Hyeon Chang), Kim, J. (Jeongseon), Kim, Y.-Y. (Yeon-Yong), Klumbiene, J. (Jurate), Knoflach, M. (Michael), Ko, S. (Stephanie), Kohler, H.-P. (Hans-Peter), Kohler, I.V. (Iliana V.), Kolle, E. (Elin), Kolsteren, P. (Patrick), König, J. (Jürgen), Korpelainen, R. (Raija), Korrovits, P. (Paul), Kos, J. (Jelena), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Kowlessur, S. (Sudhir), Kratzer, W. (Wolfgang), Kriemler, S. (Susi), Kristensen, P.L. (Peter Lund), Krokstad, S. (Steiner), Kromhout, D. (Daan), Kujala, U.M. (Urho), Kurjata, P. (Pawel), Kyobutungi, C. (Catherine), Laamiri, F.Z. (Fatima Zahra), Laatikainen, T. (Tiina), Lachat, C. (Carl), Laid, Y. (Youcef), Lam, T.H. (Tai Hing), Lambrinou, C.-P. (Christina-Paulina), Lanska, V. (Vera), Lappas, G. (Georg), Larijani, B. (Bagher), Latt, T.S. (Tint Swe), Laugsand, L.E. (Lars E.), Lazo-Porras, M. (Maria), Lee, J. (Jeannette), Lee, J. (Jeonghee), Lehmann, N. (Nils), Lehtimäki, T. (Terho), Levitt, N.S. (Naomi S.), Li, Y. (Yanping), Lilly, C.L. (Christa L.), Lim, W.-Y. (Wei-Yen), Lima-Costa, M.F. (Maria Fernanda), Lin, H.-H. (Hsien-Ho), Lin, X. (Xu), Lin, Y.-T. (Yi-Ting), Kao, W.H.L. (Wen), Linneberg, A. (Allan), Lissner, L. (Lauren), Liu, J. (Jing), Loit, H.-M. (Helle-Mai), Lopez-Garcia, E. (Esther), Lopez, T. (Tania), Lotufo, P.A. (Paulo A), Lozano, J.E. (José Eugenio), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lundqvist, R. (Robert), Lunet, N. (Nuno), Ma, G. (Guansheng), Machado-Coelho, G.L.L. (George L. L.), Machado-Rodrigues, A.M. (Aristides M.), Machi, S. (Suka), Madar, A.A. (Ahmed A.), Maggi, S. (Stefania), Magliano, D.J., Magriplis, E. (Emmanuella), Mahasampath, G. (Gowri), Maire, B. (Bernard), Makdisse, M. (Marcia), Malekzadeh, F. (Fatemeh), Malekzadeh, R. (Reza), Rao, K.M. (Kodavanti Mallikharjuna), Manios, Y., Mann, J.I. (Jim I.), Mansour-Ghanaei, F. (Fariborz), Manzato, E. (Enzo), Marques-Vidal, P. (Pedro), Martorell, R. (Reynaldo), Mascarenhas, L.P. (Luis P.), Mathiesen, E.B. (Ellisiv), Matsha, T.E. (Tandi E.), Mavrogianni, C. (Christina), McFarlane, S.R. (Shelly R.), McGarvey, S.T. (Stephen T.), McLachlan, S. (Stela), McLean, R.M. (Rachael M.), McLean, S.B. (Scott B.), McNulty, B.A. (Breige A.), Mediene-Benchekor, S. (Sounnia), Mehdipour, P. (Parinaz), Mehlig, K. (Kirsten), Mehrparvar, A.H. (Amir Houshang), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Menezes, A.M.B. (Ana M.B.), Menon, G.R. (Geetha R.), Merat, S. (Shahin), Mereke, A. (Alibek), Meshram, I.I. (Indrapal I.), Metcalf, P. (Patricia), Meyer, H.E. (Haakon E.), Mi, J. (Jie), Michels, N. (Nathalie), Miller, J.C. (Jody C.), Minderico, C.S. (Cláudia S.), Mini, G.K. (G. K.), Miquel, J.F. (Juan Francisco), Miranda, J.J. (J. Jaime), Mirjalili, M.R. (Mohammad Reza), Mirrakhimov, E. (Erkin), Modesti, P.A. (Pietro A.), Moghaddam, S.S. (Sahar Saeedi), Mohajer, B. (Bahram), Mohamed, M.K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadi, Z. (Zahra), Mohammadifard, N. (Noushin), Mohammadpourhodki, R. (Reza), Mohan, V. (Viswanathan), Mohanna, S. (Salim), Yusoff, M.F.M. (Muhammad Fadhli Mohd), Mohebbi, I. (Iraj), Mohebi, F. (Farnam), Moitry, M. (Marie), Møllehave, L.T. (Line T.), Møller, N.C. (Niels C.), Molnár, D. (Dénes), Momenan, A. (Amirabbas), Mondo, C.K. (Charles K.), Monterrubio-Flores, E. (Eric), Moosazadeh, M. (Mahmood), Morejon, A. (Alain), Moreno, L. (Luis), Morgan, K. (Karen), Morin, S.N. (Suzanne N.), Moschonis, G. (George), Mossakowska, M. (Malgorzata), Mostafa, A. (Aya), Mota, J. (Jorge), Motlagh, M.E. (Mohammad Esmaeel), Motta, J. (Jorge), Msyamboza, K.P. (Kelias P.), Muiesan, M.L. (Maria Lorenza), Müller-Nurasyid, M. (Martina), Mursu, J. (Jaakko), Mustafa, N. (Norlaila), Nabipour, I. (Iraj), Naderimagham, S. (Shohreh), Nagel, G. (Gabriele), Naidu, B.M. (Balkish M.), Najafi, F. (Farid), Nakamura, H. (Harunobu), Námešná, J. (Jana), Nang, E.E.K. (Ei Ei K.), Nangia, V.B. (Vinay B.), Nauck, M. (Matthias), Neal, W.A. (William A.), Nejatizadeh, A. (Azim), Nenko, I. (Ilona), Nervi, F. (Flavio), Nguyen, N.D. (Nguyen D.), Nguyen, Q.N. (Quang Ngoc), Nieto-Martínez, R.E. (Ramfis E.), Nihal, T. (Thomas), Niiranen, T.J. (Teemu J.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Noale, M. (Marianna), Noboa, O.A. (Oscar A.), Noto, D. (Davide), Nsour, M.A. (Mohannad Al), Nuhoğlu, I. (Irfan), O’Neill, T.W. (Terence W.), O’Reilly, D. (Dermot), Ochoa-Avilés, A.M. (Angélica M.), Oh, K. (Kyungwon), Ohtsuka, R. (Ryutaro), Olafsson, Ö. (Örn), Olié, V. (Valérie), Oliveira, I.O. (Isabel O.), Omar, M.A. (Mohd Azahadi), Onat, A. (Altan), Ong, S.K. (Sok King), Ordunez, P. (Pedro), Ornelas, R. (Rui), Ortiz, P.J. (Pedro J.), Osmond, C. (Clive), Ostojic, S.M. (Sergej M.), Ostovar, A. (Afshin), Otero, J.A. (Johanna A.), Owusu-Dabo, E. (Ellis), Paccaud, F.M. (Fred Michel), Pahomova, E. (Elena), Pajak, A. (Andrzej), Palmieri, L. (Luigi), Pan, W.-H. (Wen-Harn), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Parnell, W.R. (Winsome R.), Patel, N.D. (Nikhil D.), Peer, N. (Nasheeta), Peixoto, S.V. (Sergio Viana), Peltonen, M. (Markku), Pereira, A. (A.), Peters, A. (Annette), Petersmann, A. (Astrid), Petkeviciene, J. (Janina), Peykari, N. (Niloofar), Pham, S.T. (Son Thai), Pichardo, R.N. (Rafael N.), Pigeot, I. (Iris), Pilav, A. (Aida), Pilotto, A. (Alberto), Piwonska, A. (Aleksandra), Pizarro, A.N. (Andreia N.), Plans-Rubió, P. (Pedro), Plata, S. (Silvia), Pohlabeln, H. (Hermann), Porta, M. (Miquel), Portegies, M.L.P. (Marileen), Poudyal, A. (Anil), Pourfarzi, F. (Farhad), Poustchi, H. (Hossein), Pradeepa, R. (Rajendra), Price, J.F. (Jacqueline F.), Providencia, R. (Rui), Puder, J.J. (Jardena J.), Puhakka, S.E. (Soile E.), Punab, M. (Margus), Qorbani, M. (Mostafa), Bao, T.Q. (Tran Quoc), Radisauskas, R. (Ricardas), Rahimikazerooni, S. (Salar), Raitakari, O. (Olli), Rao, S.R. (Sudha Ramachandra), Ramachandran, A. (Ambady), Ramos, E. (Elisabete), Ramos, R. (Rafel), Rampal, L. (Lekhraj), Rampal, S. (Sanjay), Redón, J. (Josep), Reganit, P.F.M. (Paul Ferdinand M.), Revilla, L. (Luis), Rezaianzadeh, A. (Abbas), Ribeiro, R. (Robespierre), Richter, A. (Adrian), Rigo, F. (Fernando), Rinke de Wit, T.F. (Tobias), Rodríguez Artalejo, F. (Fernando), del Cristo Rodriguez-Perez, M. (María), Rodríguez-Villamizar, L.A. (Laura A.), Roggenbuck, U. (Ulla), Rojas-Martinez, R. (Rosalba), Romaguera, D. (Dora), Romeo, E.L. (Elisabetta L.), Rosengren, A. (Annika), Roy, J.G.R. (Joel G. R.), Rubinstein, A. (Adolfo), Ruidavets, J.-B. (Jean-Bernard), Ruiz-Betancourt, B.S. (Blanca Sandra), Russo, P. (Paola), Rust, P. (Petra), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H.S. (Harshpal S.), Sadjadi, A. (Alireza), Safarpour, A.R. (Ali Reza), Safiri, S. (Saeid), Saidi, O. (Olfa), Saki, N. (Nader), Salanave, B. (Benoit), Salmerón, D. (Diego), Salomaa, V. (Veikko), Salonen, J.T. (Jukka T.), Salvetti, M. (Massimo), Sánchez-Abanto, J. (Jose), Sans, S. (Susana), Santaliestra-Pasías, A.M. (Alba M.), Santos, D.A. (Diana A.), Santos, M.P. (Maria Paula), Santos, R. (Rute), Saramies, J.L. (Jouko L.), Sardinha, L.B. (Luis B.), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S., Sawada, N. (Norie), Sbaraini, M. (Mariana), Scazufca, M. (Marcia), Schaan, B.D. (Beatriz D.), Schargrodsky, H. (Herman), Scheidt-Nave, C. (C.), Schienkiewitz, A. (Anja), Schipf, S. (Sabine), Schmidt, C.O. (Carsten O.), Schöttker, B. (Ben), Schramm, S. (Sara), Sebert, S. (Sylvain), Sein, A.A. (Aye Aye), Sen, A. (Abhijit), Sepanlou, S.G. (Sadaf G), Servais, J. (Jennifer), Shakeri, R. (Ramin), Shalnova, S.A. (Svetlana A.), Shamah-Levy, T. (Teresa), Sharafkhah, M. (Maryam), Sharma, S.K. (Sanjib K.), Shaw, J.E., Shayanrad, A. (Amaneh), Shi, Z. (Zumin), Shibuya, K. (Kenji), Shimizu-Furusawa, H. (Hana), Shin, D.W. (Dong Wook), Shin, Y. (Youchan), Shirani, M. (Majid), Shiri, R. (Rahman), Shrestha, N. (Namuna), Si-Ramlee, K. (Khairil), Siani, A. (Alfonso), Siantar, R. (Rosalynn), Sibai, A.M. (Abla M.), Silva, D.A.S. (Diego Augusto Santos), Simon, M. (Mary), Simons, J. (Judith), Simons, L.A. (Leon A.), Sjöström, M. (Michael), Skaaby, T. (Tea), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smeeth, L. (Liam), Snijder, M.B. (Marieke), Söderberg, S. (Stefan), Soemantri, A. (Augustinus), Sofat, R. (Reecha), Solfrizzi, V. (Vincenzo), Somi, M.H. (Mohammad Hossein), Sonestedt, E. (Emily), Sørensen, T.I.A. (Thorkild), Jérome, C.S. (Charles Sossa), Soumaré, A. (Aicha), Sozmen, K. (Kaan), Sparrenberger, K. (Karen), Staessen, J.A. (Jan), Stathopoulou, M.G. (Maria G), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A.D. (Aryeh D.), Stessman, J. (Jochanan), Stevanović, R. (Ranko), Stieber, J. (Jutta), Stöckl, D. (Doris), Stokwiszewski, J. (Jakub), Stronks, K. (Karien), Strufaldi, M.W. (Maria Wany), Suárez-Medina, R. (Ramón), Sun, C.-A. (Chien-An), Sundström, J. (Johan), Suriyawongpaisal, P. (Paibul), Sy, R.G. (Rody G.), Sylva, R.C. (René Charles), Szklo, M. (Moyses), Tai, E.S. (Shyong), Tamosiunas, A. (Abdonas), Tan, E.J. (Eng Joo), Tarawneh, M.R. (Mohammed Rasoul), Tarqui-Mamani, C.B. (Carolina B.), Taylor, A. (Anne), Taylor, J. (Julie), Tell, G.S. (Grethe S.), Tello, T. (Tania), Thankappan, K.R. (K. R.), Thijs, L. (Lutgarde), Thuesen, B.H. (Betina H.), Toft, U. (Ulla), Tolonen, H.K. (Hanna K.), Tolstrup, J.S. (Janne), Topbas, M. (Murat), Topór-Madry, R. (Roman), Tormo, M.J., Tornaritis, M.J. (Michael J.), Torrent, M. (Maties), Torres-Collado, L. (Laura), Traissac, P. (Pierre), Trinh, O.T.H. (Oanh T. H.), Truthmann, J. (Julia), Tsugane, S. (Shoichiro), Tulloch-Reid, M.K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Tuomilehto, J. (Jaakko), Tybjaerg-Hansen, A. (Anne), Tzourio, C. (Christophe), Ueda, P. (Peter), Ugel, E. (Eunice), Ulmer, H. (Hanno), Unal, B. (Belgin), Uusitalo, H., Valdivia, G. (Gonzalo), Valvi, D. (Damaskini), Dam, R.M. (Rob) van, Schouw, Y.T. (Yvonne) van der, Van Herck, K. (Koen), Van Minh, H. (Hoang), Rossem, L. (Lenie) van, Schoor, N.M. (Natasja) van, Valkengoed, I. (Irene) van, Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Varbo, A. (Anette), Varona-Pérez, P. (Patricia), Vasan, S.K. (Senthil K.), Vatten, L. (Lars), Vega, T. (Tomas), Veidebaum, T. (Toomas), Velasquez-Melendez, G. (Gustavo), Venero-Fernández, S.J. (Silvia J.), Veronesi, G. (Giovanni), Verschuren, W.M.M. (W. M. Monique), Victora, C.G. (Cesar G.), Vidiawati, D. (Dhanasari), Viet, L. (Lucie), Villalpando, S. (Salvador), Vioque, J. (Jesus), Virtanen, J.K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vlasoff, T. (Tiina), Vollenweider, P. (Peter), Voutilainen, A. (Ari), Wade, A.N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Bebakar, W.M.W. (Wan Mohamad Wan), Mohamud, W.N.W. (Wan Nazaimoon Wan), Wang, M.-D. (Ming-Dong), Wang, N. (Ningli), Wang, Q. (Qian), Wang, Y.X. (Ya Xing), Wang, Y.-W. (Ying-Wei), Wannamethee, S.G. (Goya), Wedderkopp, N. (Niels), Wei, W. (Wenbin), Whincup, P.H. (Peter), Widhalm, K. (Kurt), Widyahening, I.S. (Indah S.), Wiecek, A. (Andrzej), Wijga, A.H. (Alet), Wilks, R.J. (Rainford J.), Willeit, J. (Johann), Willeit, P. (Peter), Wilsgaard, T. (Tom), Wojtyniak, B. (Bogdan), Wong-McClure, R.A. (Roy A.), Wong, A. (Andrew), Wong, T.Y. (Tien Yin), Woo, J. (Jean), Woodward, M. (Mark), Wu, F.C. (Frederick C.), Wu, S. (Shouling), Xu, H. (Haiquan), Xu, L. (Liang), Yan, W. (Weili), Yang, X. (Xiaoguang), Yasuharu, T. (Tabara), Ye, X. (Xingwang), Yeow, T.P. (Toh Peng), Yiallouros, P.K. (P.), Yoosefi, M. (Moein), Yoshihara, A. (Akihiro), You, S.-L. (San-Lin), Younger-Coleman, N.O. (Novie O.), Yusoff, A.F. (Ahmad Faudzi), Zainuddin, A.A. (Ahmad A.), Zakavi, S.R. (Seyed Rasoul), Zali, M.R. (Mohammad Reza), Zamani, F. (Farhad), Zambon, S. (Sabina), Zampelas, A. (Antonis), Zaw, K.K. (Ko Ko), Zdrojewski, T. (T.), Vrkic, T.Z. (Tajana Zeljkovic), Zhang, Z.-Y. (Zhen-Yu), Zhao, W. (Wenhua), Zhen, S. (Shiqi), Zheng, Y. (Yingfeng), Zholdin, B. (Bekbolat), Zhussupov, B. (Baurzhan), Zoghlami, N. (Nada), Cisneros, J.Z. (Julio Zuñiga), Gregg, E.W. (Edward W.), Ezzati, M. (Majid), Taddei, C. (Cristina), Zhou, B. (Bin), Bixby, H. (Honor), Carrillo-Larco, R.M. (Rodrigo M.), Danaei, G. (Goodarz), Jackson, R.T. (Rod T.), Farzadfar, F. (Farshad), Sophiea, M.K. (Marisa K.), Di Cesare, M. (Mariachiara), Iurilli, M.L.C. (Maria Laura Caminia), Martinez, A.R. (Andrea Rodriguez), Asghari, G. (Golaleh), Dhana, K. (Klodian), Gulayin, P. (Pablo), Kakarmath, S. (Sujay), Santero, M. (Marilina), Voortman, R.G. (Trudy), Riley, L.M. (Leanne M.), Cowan, M.J. (Melanie J.), Savin, S. (Stefan), Bennett, J.E. (James E.), Stevens, G.A. (Gretchen A.), Paciorek, C.J. (Christopher J.), Aekplakorn, W. (Wichai), Cifkova, R. (Renata), Giampaoli, S. (Simona), Kengne, A.P. (Andre Pascal), Khang, Y.-H. (Young-Ho), Kuulasmaa, K. (Kari), Laxmaiah, A. (Avula), Margozzini, P. (Paula), Mathur, P. (Prashant), Nordestgaard, B.G. (Børge), Zhao, D. (Dong), Aadahl, M. (Mette), Abarca-Gómez, L. (Leandra), Rahim, H.A. (Hanan Abdul), Abu-Rmeileh, N.M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R.J. (Robert J.), Agdeppa, I.A. (Imelda A.), Aghazadeh-Attari, J. (Javad), Aguilar-Salinas, C.A. (Carlos A.), Agyemang, C.O. (Charles), Ahluwalia, T.S. (Tarunveer Singh), Ahmad, N.A. (Noor Ani), Ahmadi, A. (Ali), Ahmadi, N. (Naser), Ahmed, S.H. (Soheir H.), Ahrens, W. (W.), Ajlouni, K. (Kamel), Alarouj, M. (Monira), AlBuhairan, F. (Fadia), AlDhukair, S. (Shahla), Ali, M.M. (Mohamed M.), Alkandari, A. (Abdullah), Alkerwi, A. (Ala’a), Aly, E. (Eman), Amarapurkar, D.N. (Deepak N.), Amouyel, P. (Philippe), Andersen, L.B. (Lars Bo), Anderssen, S.A. (Sigmund A.), Anjana, R.M. (Ranjit Mohan), Ansari-Moghaddam, A. (Alireza), Aounallah-Skhiri, H. (Hajer), Araújo, J. (Joana), Ariansen, I. (Inger), Aris, T. (Tahir), Arku, R.E. (Raphael E.), Arlappa, N. (Nimmathota), Aryal, K.K. (Krishna K.), Aspelund, T. (Thor), Assunção, M.C.F. (Maria Cecília F.), Auvinen, J. (Juha), Avdicová, M. (Mária), Azevedo, A. (Ana), Azizi, J. (Joshan), Azmin, M. (Mehrdad), Balakrishna, N. (Nagalla), Bamoshmoosh, M. (Mohamed), Banach, M. (Maciej), Bandosz, P. (Piotr), Banegas, J.R. (José R.), Barbagallo, C.M. (Carlo M.), Barceló, A. (Alberto), Barkat, A. (Amina), Bata, I. (Iqbal), Batieha, A.M. (Anwar M.), Batyrbek, A. (Assembekov), Baur, L.A. (Louise A.), Beaglehole, R. (Robert), Belavendra, A. (Antonisamy), Ben Romdhane, H. (Habiba), Benet, M. (Mikhail), Benn, M. (Marianne), Berkinbayev, S. (Salim), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhargava, S.K. (Santosh K.), Bi, Y. (Yufang), Bienek, A. (Asako), Bikbov, M. (Mukharram), Bista, B. (Bihungum), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjertness, M.B. (Marius B.), Björkelund, C. (Cecilia), Bloch, K.V. (Katia V.), Blokstra, A. (Anneke), Bo, S. (Simona), Boehm, B.O. (Bernhard O.), Boggia, J.G. (Jose G.), Boissonnet, C.P. (Carlos P.), Bonaccio, M. (Marialaura), Bongard, V. (Vanina), Borchini, R. (Rossana), Borghs, H. (Herman), Bovet, P. (Pascal), Brajkovich, I. (Imperia), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L.M. (Lizzy), Bruno, G. (Graziella), Bugge, A. (Anna), Busch, M.A. (Markus A.), de León, A.C. (Antonio Cabrera), Cacciottolo, J. (Joseph), Can, G. (Günay), Cândido, A.P.C. (Ana Paula C.), Capanzana, M.V. (Mario V.), Capuano, E. (Eduardo), Capuano, V. (Vincenzo), Cardoso, V.C. (Viviane C.), Carvalho, J. (Joana), Casanueva, F.F., Censi, L. (Laura), Chadjigeorgiou, C.A. (Charalambos A.), Chamukuttan, S. (Snehalatha), Chaturvedi, N. (Nish), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, S. (Shuohua), Cheng, C.-Y. (Ching-Yu), Cheraghian, B. (Bahman), Chetrit, A. (Angela), Chiou, S.-T. (Shu-Ti), Chirlaque, M.D. (M.), Cho, B. (Belong), Cho, Y. (Yumi), Chudek, J. (Jerzy), Claessens, F. (Frank), Clarke, J. (Janine), Clays, E. (Els), Concin, H. (Hans), Confortin, S.C. (Susana C.), Cooper, C. (Charles), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Crujeiras, A.B. (Ana B.), Csilla, S. (Semánová), Cui, L. (Liufu), Cureau, F.V. (Felipe V.), D’Arrigo, G. (Graziella), d’Orsi, E. (Eleonora), Dallongeville, J., Damasceno, A. (Albertino), Dankner, R. (Rachel), Dantoft, T.M. (Thomas M.), Dauchet, L. (Luc), Davletov, K. (Kairat), Backer, G. (Guy) de, Bacquer, D. (Dirk) de, de Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), de Oliveira, P.D. (Paula Duarte), De Ridder, D. (David), De Smedt, D. (Delphine), Deepa, M. (Mohan), Deev, A.D. (Alexander D.), Dehghan, A. (Abbas), Delisle, H. (Hélène), Dennison, E.M. (Elaine), Deschamps, V. (Valérie), Dhimal, M. (Meghnath), Di Castelnuovo, A.F. (Augusto F.), Dika, Z. (Zivka), Djalalinia, S. (Shirin), Dobson, A.J. (Annette J.), Donfrancesco, C. (Chiara), Donoso, S.P. (Silvana P.), Döring, A. (Angela), Dorobantu, M. (Maria), Dragano, N. (Nico), Drygas, W. (Wojciech), Du, Y. (Yong), Duante, C.A. (Charmaine A.), Duda, R.B. (Rosemary B.), Dzerve, V. (Vilnis), Dziankowska-Zaborszczyk, E. (Elzbieta), Eddie, R. (Ricky), Eftekhar, E. (Ebrahim), Eggertsen, R. (Robert), Eghtesad, S. (Sareh), Eiben, G. (Gabriele), Ekelund, U. (Ulf), El Ati, J. (Jalila), Eldemire-Shearer, D. (Denise), Eliasen, M. (Marie), Elosua, R. (Roberto), Erasmus, R.T. (Rajiv T.), Erbel, R. (Raimund), Erem, C. (Cihangir), Eriksen, L. (Louise), Hagen, K. (Knut), Escobedo-de la Peña, J. (Jorge), Eslami, S. (Saeid), Esmaeili, A. (Ali), Evans, A. (Alun), Faeh, D. (David), Fall, C.H. (Caroline H.), Faramarzi, E. (Elnaz), Farjam, M. (Mojtaba), Fattahi, M.R. (Mohammad Reza), Felix-Redondo, F.J. (Francisco J.), Ferguson, T.S. (Trevor S.), Fernández-Bergés, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Föger, B. (Bernhard), Foo, L.H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Forsner, M. (Maria), Fouad, H.M. (Heba M.), Francis, D.K. (Damian K.), do Carmo Franco, M. (Maria), Franco, O.H. (Oscar H.), Frontera, G. (Guillermo), Fujita, Y. (Yuki), Fumihiko, M. (Matsuda), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Galvano, F. (Fabio), Gao, J. (Jingli), Garcia-de-la-Hera, M. (Manoli), Garnett, S.P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gazzinelli, A. (Andrea), Geleijnse, J.M. (Marianne), Ghanbari, A. (Ali), Ghasemi, E. (Erfan), Gheorghe-Fronea, O.-F. (Oana-Florentina), Ghimire, A. (Anup), Gianfagna, F. (Francesco), Gill, T.K. (Tiffany K.), Giovannelli, J. (Jonathan), Gironella, G. (Glen), Giwercman, A. (Aleksander), Goltzman, D. (David), Gonçalves, H. (Helen), Gonzalez-Chica, D.A. (David A.), Gonzalez-Gross, M. (Marcela), González-Rivas, J.P. (Juan P.), González-Villalpando, C. (Clicerio), González-Villalpando, M.E. (María Elena), Gonzalez, A.R. (Angel R.), Gottrand, F., Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dušan), Gregor, R.D. (Ronald D.), Grodzicki, T. (Tomasz), Grøntved, A. (Anders), Grosso, G. (Giuseppe), Gruden, G. (Gabriella), Gu, D. (Dongfeng), Guallar-castillón, P. (Pilar), Guan, O.P. (Ong Peng), Gudmundsson, E.F. (Elias F.), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Gunnlaugsdottir, J. (Johanna), Gupta, R. (Rajeev), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Ha, S. (Seongjun), Hadaegh, F. (Farzad), Haghshenas, R. (Rosa), Hakimi, H. (Hamid), Hambleton, I.R. (Ian R.), Hamzeh, B. (Behrooz), Hantunen, S. (Sari), Kumar, R.H. (Rachakulla Hari), Hashemi-Shahri, S.M. (Seyed Mohammad), Hata, J. (Jun), Haugsgjerd, T. (Teresa), Hayes, A.J. (Alison J.), He, J. (Jiang), He, Y. (Yong), Hendriks, M.E. (Marleen), Henriques, A. (Ana), Herrala, S. (Sauli), Heshmat, R. (Ramin), Hill, A.G. (Allan G.), Ho, S.Y. (Sai Yin), Ho, S.C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Homayounfar, R. (Reza), Hopman, W.M. (Wilma M.), Horimoto, A.R.V.R. (Andrea R. V. R.), Hormiga, C.M. (Claudia M.), Horta, B.L. (Bernardo L.), Houti, L. (Leila), Howitt, C. (Christina), Htay, T.T. (Thein Thein), Htet, A.S. (Aung Soe), Htike, M.M.T. (Maung Maung Than), Huerta, J.M. (José María), Huhtaniemi, I.T. (I.), Huisman, M. (Martijn), Hunsberger, M.L. (Monica L.), Husseini, A. (Abdullatif), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A.G. (Anna G.), Ibrahim, M.M. (Mohsen), Wong, N.I. (Norazizah Ibrahim), Iglesia, I. (Iris), Ikeda, N. (Nayu), Ikram, M.A. (Arfan), Iotova, V. (Violeta), Irazola, V.E. (Vilma E.), Ishida, T. (Takafumi), Islam, M. (Muhammad), al-Safi Ismail, A. (Aziz), Iwasaki, M. (Masanori), Jacobs, J.M. (Jeremy M.), Jaddou, H.Y. (Hashem Y.), Jafar, T.H. (Tazeen), James, K. (Kenneth), Jamrozik, K., Janszky, I. (Imre), Janus, E. (Edward), Jarvelin, M.-R. (Marjo-Riitta), Jasienska, G. (Grazyna), Jelakovic, A. (Ana), Jelakovic, B. (Bojan), Jennings, G. (Garry), Jensen, G.B. (Gorm), Jeong, S.-L. (Seung-lyeal), Jha, A.K. (Anjani Kumar), Jiang, C.Q. (Chao Qiang), Jimenez, R.O. (Ramon O.), JöCkel, K.-H. (Karl-Heinz), Joffres, M. (Michel), Jokelainen, J.J. (Jari J.), Jonas, J.B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Joukar, F. (Farahnaz), Józwiak, J. (Jacek), Juolevi, A. (Anne), Kafatos, A. (Anthony), Kajantie, E. (Eero), Kalter-Leibovici, O. (Ofra), Kamaruddin, N.A. (Nor Azmi), Kamstrup, P.R. (Pia R.), Karki, K.B. (Khem B.), Katz, J. (Joanne), Kauhanen, J. (Jussi), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Kazakbaeva, G. (Gyulli), Keil, M. (Mark), Keinanen-Kiukaanniemi, S. (Sirkka), Kelishadi, R. (Roya), Keramati, M. (Maryam), Kerimkulova, A. (Alina), Kersting, M. (Mathilde), Khader, Y.S. (Yousef Saleh), Khalili, D. (Davood), Khateeb, M. (Mohammad), Kheradmand, M. (Motahareh), Khosravi, A. (Alireza), Kiechl-Kohlendorfer, U. (Ursula), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, H.C. (Hyeon Chang), Kim, J. (Jeongseon), Kim, Y.-Y. (Yeon-Yong), Klumbiene, J. (Jurate), Knoflach, M. (Michael), Ko, S. (Stephanie), Kohler, H.-P. (Hans-Peter), Kohler, I.V. (Iliana V.), Kolle, E. (Elin), Kolsteren, P. (Patrick), König, J. (Jürgen), Korpelainen, R. (Raija), Korrovits, P. (Paul), Kos, J. (Jelena), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Kowlessur, S. (Sudhir), Kratzer, W. (Wolfgang), Kriemler, S. (Susi), Kristensen, P.L. (Peter Lund), Krokstad, S. (Steiner), Kromhout, D. (Daan), Kujala, U.M. (Urho), Kurjata, P. (Pawel), Kyobutungi, C. (Catherine), Laamiri, F.Z. (Fatima Zahra), Laatikainen, T. (Tiina), Lachat, C. (Carl), Laid, Y. (Youcef), Lam, T.H. (Tai Hing), Lambrinou, C.-P. (Christina-Paulina), Lanska, V. (Vera), Lappas, G. (Georg), Larijani, B. (Bagher), Latt, T.S. (Tint Swe), Laugsand, L.E. (Lars E.), Lazo-Porras, M. (Maria), Lee, J. (Jeannette), Lee, J. (Jeonghee), Lehmann, N. (Nils), Lehtimäki, T. (Terho), Levitt, N.S. (Naomi S.), Li, Y. (Yanping), Lilly, C.L. (Christa L.), Lim, W.-Y. (Wei-Yen), Lima-Costa, M.F. (Maria Fernanda), Lin, H.-H. (Hsien-Ho), Lin, X. (Xu), Lin, Y.-T. (Yi-Ting), Kao, W.H.L. (Wen), Linneberg, A. (Allan), Lissner, L. (Lauren), Liu, J. (Jing), Loit, H.-M. (Helle-Mai), Lopez-Garcia, E. (Esther), Lopez, T. (Tania), Lotufo, P.A. (Paulo A), Lozano, J.E. (José Eugenio), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lundqvist, R. (Robert), Lunet, N. (Nuno), Ma, G. (Guansheng), Machado-Coelho, G.L.L. (George L. L.), Machado-Rodrigues, A.M. (Aristides M.), Machi, S. (Suka), Madar, A.A. (Ahmed A.), Maggi, S. (Stefania), Magliano, D.J., Magriplis, E. (Emmanuella), Mahasampath, G. (Gowri), Maire, B. (Bernard), Makdisse, M. (Marcia), Malekzadeh, F. (Fatemeh), Malekzadeh, R. (Reza), Rao, K.M. (Kodavanti Mallikharjuna), Manios, Y., Mann, J.I. (Jim I.), Mansour-Ghanaei, F. (Fariborz), Manzato, E. (Enzo), Marques-Vidal, P. (Pedro), Martorell, R. (Reynaldo), Mascarenhas, L.P. (Luis P.), Mathiesen, E.B. (Ellisiv), Matsha, T.E. (Tandi E.), Mavrogianni, C. (Christina), McFarlane, S.R. (Shelly R.), McGarvey, S.T. (Stephen T.), McLachlan, S. (Stela), McLean, R.M. (Rachael M.), McLean, S.B. (Scott B.), McNulty, B.A. (Breige A.), Mediene-Benchekor, S. (Sounnia), Mehdipour, P. (Parinaz), Mehlig, K. (Kirsten), Mehrparvar, A.H. (Amir Houshang), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Menezes, A.M.B. (Ana M.B.), Menon, G.R. (Geetha R.), Merat, S. (Shahin), Mereke, A. (Alibek), Meshram, I.I. (Indrapal I.), Metcalf, P. (Patricia), Meyer, H.E. (Haakon E.), Mi, J. (Jie), Michels, N. (Nathalie), Miller, J.C. (Jody C.), Minderico, C.S. (Cláudia S.), Mini, G.K. (G. K.), Miquel, J.F. (Juan Francisco), Miranda, J.J. (J. Jaime), Mirjalili, M.R. (Mohammad Reza), Mirrakhimov, E. (Erkin), Modesti, P.A. (Pietro A.), Moghaddam, S.S. (Sahar Saeedi), Mohajer, B. (Bahram), Mohamed, M.K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadi, Z. (Zahra), Mohammadifard, N. (Noushin), Mohammadpourhodki, R. (Reza), Mohan, V. (Viswanathan), Mohanna, S. (Salim), Yusoff, M.F.M. (Muhammad Fadhli Mohd), Mohebbi, I. (Iraj), Mohebi, F. (Farnam), Moitry, M. (Marie), Møllehave, L.T. (Line T.), Møller, N.C. (Niels C.), Molnár, D. (Dénes), Momenan, A. (Amirabbas), Mondo, C.K. (Charles K.), Monterrubio-Flores, E. (Eric), Moosazadeh, M. (Mahmood), Morejon, A. (Alain), Moreno, L. (Luis), Morgan, K. (Karen), Morin, S.N. (Suzanne N.), Moschonis, G. (George), Mossakowska, M. (Malgorzata), Mostafa, A. (Aya), Mota, J. (Jorge), Motlagh, M.E. (Mohammad Esmaeel), Motta, J. (Jorge), Msyamboza, K.P. (Kelias P.), Muiesan, M.L. (Maria Lorenza), Müller-Nurasyid, M. (Martina), Mursu, J. (Jaakko), Mustafa, N. (Norlaila), Nabipour, I. (Iraj), Naderimagham, S. (Shohreh), Nagel, G. (Gabriele), Naidu, B.M. (Balkish M.), Najafi, F. (Farid), Nakamura, H. (Harunobu), Námešná, J. (Jana), Nang, E.E.K. (Ei Ei K.), Nangia, V.B. (Vinay B.), Nauck, M. (Matthias), Neal, W.A. (William A.), Nejatizadeh, A. (Azim), Nenko, I. (Ilona), Nervi, F. (Flavio), Nguyen, N.D. (Nguyen D.), Nguyen, Q.N. (Quang Ngoc), Nieto-Martínez, R.E. (Ramfis E.), Nihal, T. (Thomas), Niiranen, T.J. (Teemu J.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Noale, M. (Marianna), Noboa, O.A. (Oscar A.), Noto, D. (Davide), Nsour, M.A. (Mohannad Al), Nuhoğlu, I. (Irfan), O’Neill, T.W. (Terence W.), O’Reilly, D. (Dermot), Ochoa-Avilés, A.M. (Angélica M.), Oh, K. (Kyungwon), Ohtsuka, R. (Ryutaro), Olafsson, Ö. (Örn), Olié, V. (Valérie), Oliveira, I.O. (Isabel O.), Omar, M.A. (Mohd Azahadi), Onat, A. (Altan), Ong, S.K. (Sok King), Ordunez, P. (Pedro), Ornelas, R. (Rui), Ortiz, P.J. (Pedro J.), Osmond, C. (Clive), Ostojic, S.M. (Sergej M.), Ostovar, A. (Afshin), Otero, J.A. (Johanna A.), Owusu-Dabo, E. (Ellis), Paccaud, F.M. (Fred Michel), Pahomova, E. (Elena), Pajak, A. (Andrzej), Palmieri, L. (Luigi), Pan, W.-H. (Wen-Harn), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Parnell, W.R. (Winsome R.), Patel, N.D. (Nikhil D.), Peer, N. (Nasheeta), Peixoto, S.V. (Sergio Viana), Peltonen, M. (Markku), Pereira, A. (A.), Peters, A. (Annette), Petersmann, A. (Astrid), Petkeviciene, J. (Janina), Peykari, N. (Niloofar), Pham, S.T. (Son Thai), Pichardo, R.N. (Rafael N.), Pigeot, I. (Iris), Pilav, A. (Aida), Pilotto, A. (Alberto), Piwonska, A. (Aleksandra), Pizarro, A.N. (Andreia N.), Plans-Rubió, P. (Pedro), Plata, S. (Silvia), Pohlabeln, H. (Hermann), Porta, M. (Miquel), Portegies, M.L.P. (Marileen), Poudyal, A. (Anil), Pourfarzi, F. (Farhad), Poustchi, H. (Hossein), Pradeepa, R. (Rajendra), Price, J.F. (Jacqueline F.), Providencia, R. (Rui), Puder, J.J. (Jardena J.), Puhakka, S.E. (Soile E.), Punab, M. (Margus), Qorbani, M. (Mostafa), Bao, T.Q. (Tran Quoc), Radisauskas, R. (Ricardas), Rahimikazerooni, S. (Salar), Raitakari, O. (Olli), Rao, S.R. (Sudha Ramachandra), Ramachandran, A. (Ambady), Ramos, E. (Elisabete), Ramos, R. (Rafel), Rampal, L. (Lekhraj), Rampal, S. (Sanjay), Redón, J. (Josep), Reganit, P.F.M. (Paul Ferdinand M.), Revilla, L. (Luis), Rezaianzadeh, A. (Abbas), Ribeiro, R. (Robespierre), Richter, A. (Adrian), Rigo, F. (Fernando), Rinke de Wit, T.F. (Tobias), Rodríguez Artalejo, F. (Fernando), del Cristo Rodriguez-Perez, M. (María), Rodríguez-Villamizar, L.A. (Laura A.), Roggenbuck, U. (Ulla), Rojas-Martinez, R. (Rosalba), Romaguera, D. (Dora), Romeo, E.L. (Elisabetta L.), Rosengren, A. (Annika), Roy, J.G.R. (Joel G. R.), Rubinstein, A. (Adolfo), Ruidavets, J.-B. (Jean-Bernard), Ruiz-Betancourt, B.S. (Blanca Sandra), Russo, P. (Paola), Rust, P. (Petra), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H.S. (Harshpal S.), Sadjadi, A. (Alireza), Safarpour, A.R. (Ali Reza), Safiri, S. (Saeid), Saidi, O. (Olfa), Saki, N. (Nader), Salanave, B. (Benoit), Salmerón, D. (Diego), Salomaa, V. (Veikko), Salonen, J.T. (Jukka T.), Salvetti, M. (Massimo), Sánchez-Abanto, J. (Jose), Sans, S. (Susana), Santaliestra-Pasías, A.M. (Alba M.), Santos, D.A. (Diana A.), Santos, M.P. (Maria Paula), Santos, R. (Rute), Saramies, J.L. (Jouko L.), Sardinha, L.B. (Luis B.), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S., Sawada, N. (Norie), Sbaraini, M. (Mariana), Scazufca, M. (Marcia), Schaan, B.D. (Beatriz D.), Schargrodsky, H. (Herman), Scheidt-Nave, C. (C.), Schienkiewitz, A. (Anja), Schipf, S. (Sabine), Schmidt, C.O. (Carsten O.), Schöttker, B. (Ben), Schramm, S. (Sara), Sebert, S. (Sylvain), Sein, A.A. (Aye Aye), Sen, A. (Abhijit), Sepanlou, S.G. (Sadaf G), Servais, J. (Jennifer), Shakeri, R. (Ramin), Shalnova, S.A. (Svetlana A.), Shamah-Levy, T. (Teresa), Sharafkhah, M. (Maryam), Sharma, S.K. (Sanjib K.), Shaw, J.E., Shayanrad, A. (Amaneh), Shi, Z. (Zumin), Shibuya, K. (Kenji), Shimizu-Furusawa, H. (Hana), Shin, D.W. (Dong Wook), Shin, Y. (Youchan), Shirani, M. (Majid), Shiri, R. (Rahman), Shrestha, N. (Namuna), Si-Ramlee, K. (Khairil), Siani, A. (Alfonso), Siantar, R. (Rosalynn), Sibai, A.M. (Abla M.), Silva, D.A.S. (Diego Augusto Santos), Simon, M. (Mary), Simons, J. (Judith), Simons, L.A. (Leon A.), Sjöström, M. (Michael), Skaaby, T. (Tea), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smeeth, L. (Liam), Snijder, M.B. (Marieke), Söderberg, S. (Stefan), Soemantri, A. (Augustinus), Sofat, R. (Reecha), Solfrizzi, V. (Vincenzo), Somi, M.H. (Mohammad Hossein), Sonestedt, E. (Emily), Sørensen, T.I.A. (Thorkild), Jérome, C.S. (Charles Sossa), Soumaré, A. (Aicha), Sozmen, K. (Kaan), Sparrenberger, K. (Karen), Staessen, J.A. (Jan), Stathopoulou, M.G. (Maria G), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A.D. (Aryeh D.), Stessman, J. (Jochanan), Stevanović, R. (Ranko), Stieber, J. (Jutta), Stöckl, D. (Doris), Stokwiszewski, J. (Jakub), Stronks, K. (Karien), Strufaldi, M.W. (Maria Wany), Suárez-Medina, R. (Ramón), Sun, C.-A. (Chien-An), Sundström, J. (Johan), Suriyawongpaisal, P. (Paibul), Sy, R.G. (Rody G.), Sylva, R.C. (René Charles), Szklo, M. (Moyses), Tai, E.S. (Shyong), Tamosiunas, A. (Abdonas), Tan, E.J. (Eng Joo), Tarawneh, M.R. (Mohammed Rasoul), Tarqui-Mamani, C.B. (Carolina B.), Taylor, A. (Anne), Taylor, J. (Julie), Tell, G.S. (Grethe S.), Tello, T. (Tania), Thankappan, K.R. (K. R.), Thijs, L. (Lutgarde), Thuesen, B.H. (Betina H.), Toft, U. (Ulla), Tolonen, H.K. (Hanna K.), Tolstrup, J.S. (Janne), Topbas, M. (Murat), Topór-Madry, R. (Roman), Tormo, M.J., Tornaritis, M.J. (Michael J.), Torrent, M. (Maties), Torres-Collado, L. (Laura), Traissac, P. (Pierre), Trinh, O.T.H. (Oanh T. H.), Truthmann, J. (Julia), Tsugane, S. (Shoichiro), Tulloch-Reid, M.K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Tuomilehto, J. (Jaakko), Tybjaerg-Hansen, A. (Anne), Tzourio, C. (Christophe), Ueda, P. (Peter), Ugel, E. (Eunice), Ulmer, H. (Hanno), Unal, B. (Belgin), Uusitalo, H., Valdivia, G. (Gonzalo), Valvi, D. (Damaskini), Dam, R.M. (Rob) van, Schouw, Y.T. (Yvonne) van der, Van Herck, K. (Koen), Van Minh, H. (Hoang), Rossem, L. (Lenie) van, Schoor, N.M. (Natasja) van, Valkengoed, I. (Irene) van, Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Varbo, A. (Anette), Varona-Pérez, P. (Patricia), Vasan, S.K. (Senthil K.), Vatten, L. (Lars), Vega, T. (Tomas), Veidebaum, T. (Toomas), Velasquez-Melendez, G. (Gustavo), Venero-Fernández, S.J. (Silvia J.), Veronesi, G. (Giovanni), Verschuren, W.M.M. (W. M. Monique), Victora, C.G. (Cesar G.), Vidiawati, D. (Dhanasari), Viet, L. (Lucie), Villalpando, S. (Salvador), Vioque, J. (Jesus), Virtanen, J.K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vlasoff, T. (Tiina), Vollenweider, P. (Peter), Voutilainen, A. (Ari), Wade, A.N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Bebakar, W.M.W. (Wan Mohamad Wan), Mohamud, W.N.W. (Wan Nazaimoon Wan), Wang, M.-D. (Ming-Dong), Wang, N. (Ningli), Wang, Q. (Qian), Wang, Y.X. (Ya Xing), Wang, Y.-W. (Ying-Wei), Wannamethee, S.G. (Goya), Wedderkopp, N. (Niels), Wei, W. (Wenbin), Whincup, P.H. (Peter), Widhalm, K. (Kurt), Widyahening, I.S. (Indah S.), Wiecek, A. (Andrzej), Wijga, A.H. (Alet), Wilks, R.J. (Rainford J.), Willeit, J. (Johann), Willeit, P. (Peter), Wilsgaard, T. (Tom), Wojtyniak, B. (Bogdan), Wong-McClure, R.A. (Roy A.), Wong, A. (Andrew), Wong, T.Y. (Tien Yin), Woo, J. (Jean), Woodward, M. (Mark), Wu, F.C. (Frederick C.), Wu, S. (Shouling), Xu, H. (Haiquan), Xu, L. (Liang), Yan, W. (Weili), Yang, X. (Xiaoguang), Yasuharu, T. (Tabara), Ye, X. (Xingwang), Yeow, T.P. (Toh Peng), Yiallouros, P.K. (P.), Yoosefi, M. (Moein), Yoshihara, A. (Akihiro), You, S.-L. (San-Lin), Younger-Coleman, N.O. (Novie O.), Yusoff, A.F. (Ahmad Faudzi), Zainuddin, A.A. (Ahmad A.), Zakavi, S.R. (Seyed Rasoul), Zali, M.R. (Mohammad Reza), Zamani, F. (Farhad), Zambon, S. (Sabina), Zampelas, A. (Antonis), Zaw, K.K. (Ko Ko), Zdrojewski, T. (T.), Vrkic, T.Z. (Tajana Zeljkovic), Zhang, Z.-Y. (Zhen-Yu), Zhao, W. (Wenhua), Zhen, S. (Shiqi), Zheng, Y. (Yingfeng), Zholdin, B. (Bekbolat), Zhussupov, B. (Baurzhan), Zoghlami, N. (Nada), Cisneros, J.Z. (Julio Zuñiga), Gregg, E.W. (Edward W.), and Ezzati, M. (Majid)

Abstract

High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiov

Published
2020
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5. Results from the European prospective investigation into cancer and nutrition link vitamin B6 catabolism and lung cancer risk

Author

Zuo, H. Ueland, P.M. Midttun, Ø. Vollset, S.E. Tell, G.S. Theofylaktopoulou, D. Travis, R.C. Boutron-Ruault, M.-C. Fournier, A. Severi, G. Kvaskoff, M. Boeing, H. Bergmann, M.M. Fortner, R.T. Kaaks, R. Trichopoulou, A. Kotanidou, A. Lagiou, P. Palli, D. Sieri, S. Panico, S. Bueno-De-Mesquita, H.B. Peeters, P.H. Grankvist, K. Johansson, M. Agudo, A. Garcia, J.R.Q. Larranaga, N. Sanchez, M.-J. Chirlaque, M.D. Ardanaz, E. Chuang, S.-C. Gallo, V. Brennan, P. Johansson, M. Ulvik, A. and Zuo, H. Ueland, P.M. Midttun, Ø. Vollset, S.E. Tell, G.S. Theofylaktopoulou, D. Travis, R.C. Boutron-Ruault, M.-C. Fournier, A. Severi, G. Kvaskoff, M. Boeing, H. Bergmann, M.M. Fortner, R.T. Kaaks, R. Trichopoulou, A. Kotanidou, A. Lagiou, P. Palli, D. Sieri, S. Panico, S. Bueno-De-Mesquita, H.B. Peeters, P.H. Grankvist, K. Johansson, M. Agudo, A. Garcia, J.R.Q. Larranaga, N. Sanchez, M.-J. Chirlaque, M.D. Ardanaz, E. Chuang, S.-C. Gallo, V. Brennan, P. Johansson, M. Ulvik, A.

Abstract

Circulating pyridoxal-5′-phosphate (PLP) has been linked to lung cancer risk. The PAr index, defined as the ratio 4-pyridoxic acid/(pyridoxal + PLP), reflects increased vitamin B6 catabolism during inflammation. PAr has been defined as a marker of lung cancer risk in a prospective cohort study, but analysis of a larger numbers of cases are needed to deepen the significance of this study. Here, we conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC, n 521, 330), which included 892 incident lung cancer cases and 1, 748 controls matched by center, gender, date of blood collection, and date of birth. The association of PAr with risk of lung cancer was evaluated by using conditional logistic regression. Study participants with elevated PAr experienced higher risk of lung cancer in a dose-response fashion, with a doubling in PAr levels associated with 52% higher odds of lung cancer after adjustment for tobacco smoking, serum cotinine levels, educational attainment, and BMI [OR, 1.52; 95% confidence interval (CI) 1.27-1.81; P < 0.001]. Additional adjustment for intake of vegetables and fruits and physical activity did not materially affect risk association. The association of PAr with lung cancer risk was similar in both genders but slightly stronger in former smokers and in participants diagnosed with squamous cell carcinoma. This study provides robust evidence that increased vitamin B6 catabolism is independently associated with a higher risk of future lung cancer. Significance: This large cohort study firmly establishes an association between an index of vitaminB6 levels with lung cancer risk. © 2017 American Association for Cancer Research.

Published
2018

6. Circulating Folate and Vitamin B12 and Risk of Prostate Cancer: A Collaborative Analysis of Individual Participant Data from Six Cohorts Including 6875 Cases and 8104 Controls

Author

Price, A.J. Travis, R.C. Appleby, P.N. Albanes, D. Barricarte Gurrea, A. Bjørge, T. Bueno-de-Mesquita, H.B. Chen, C. Donovan, J. Gislefoss, R. Goodman, G. Gunter, M. Hamdy, F.C. Johansson, M. King, I.B. Kühn, T. Männistö, S. Martin, R.M. Meyer, K. Neal, D.E. Neuhouser, M.L. Nygård, O. Stattin, P. Tell, G.S. Trichopoulou, A. Tumino, R. Ueland, P.M. Ulvik, A. de Vogel, S. Vollset, S.E. Weinstein, S.J. Key, T.J. Allen, N.E. on behalf of the Endogenous Hormones, Nutritional Biomarkers, Prostate Cancer Collaborative Group and Price, A.J. Travis, R.C. Appleby, P.N. Albanes, D. Barricarte Gurrea, A. Bjørge, T. Bueno-de-Mesquita, H.B. Chen, C. Donovan, J. Gislefoss, R. Goodman, G. Gunter, M. Hamdy, F.C. Johansson, M. King, I.B. Kühn, T. Männistö, S. Martin, R.M. Meyer, K. Neal, D.E. Neuhouser, M.L. Nygård, O. Stattin, P. Tell, G.S. Trichopoulou, A. Tumino, R. Ueland, P.M. Ulvik, A. de Vogel, S. Vollset, S.E. Weinstein, S.J. Key, T.J. Allen, N.E. on behalf of the Endogenous Hormones, Nutritional Biomarkers, Prostate Cancer Collaborative Group

Abstract

Background Folate and vitamin B12 are essential for maintaining DNA integrity and may influence prostate cancer (PCa) risk, but the association with clinically relevant, advanced stage, and high-grade disease is unclear. Objective To investigate the associations between circulating folate and vitamin B12 concentrations and risk of PCa overall and by disease stage and grade. Design, setting, and participants A study was performed with a nested case–control design based on individual participant data from six cohort studies including 6875 cases and 8104 controls; blood collection from 1981 to 2008, and an average follow-up of 8.9 yr (standard deviation 7.3). Odds ratios (ORs) of incident PCa by study-specific fifths of circulating folate and vitamin B12 were calculated using multivariable adjusted conditional logistic regression. Outcome measurements and statistical analysis Incident PCa and subtype by stage and grade. Results and limitations Higher folate and vitamin B12 concentrations were associated with a small increase in risk of PCa (ORs for the top vs bottom fifths were 1.13 [95% confidence interval (CI), 1.02–1.26], ptrend = 0.018, for folate and 1.12 [95% CI, 1.01–1.25], ptrend = 0.017, for vitamin B12), with no evidence of heterogeneity between studies. The association with folate varied by tumour grade (pheterogeneity < 0.001); higher folate concentration was associated with an elevated risk of high-grade disease (OR for the top vs bottom fifth: 2.30 [95% CI, 1.28–4.12]; ptrend = 0.001), with no association for low-grade disease. There was no evidence of heterogeneity in the association of folate with risk by stage or of vitamin B12 with risk by stage or grade of disease (pheterogeneity > 0.05). Use of single blood-sample measurements of folate and B12 concentrations is a limitation. Conclusions The association between higher folate concentration and risk of high-grade disease, not evident for low-grade disease, suggests a possible role for fo

Published
2016

7. A prospective study of the immune system activation biomarker neopterin and colorectal cancer risk

Author

Aleksandrova, K., Chuang, S.C., Boeing, H., Zuo, Huijuan, Tell, G.S., Pischon, T., Jenab, M., Bueno-De-Mesquita, B., Vollset, S.E., Midttun, Øivind, Ueland, P.M., Fedirko, V., Johansson, M., Weiderpass, E., Severi, G., Racine, A., Boutron-Ruault, M.C., Kaaks, R., Kühn, Tilman, Tjønneland, A., Overvad, K., Quirós, José R., Jakszyn, P., Sánchez, M.-J, Dorronsoro, M., Chirlaque, M.D., Ardanaz, E., Khaw, Kay T., Wareham, Nicholas J., Travis, Ruth C., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Sieri, S., Tumino, R., Panico, S., May, A.M., Palmqvist, R., Ljuslinder, Ingrid, Kong, S.Y.J., Freisling, H., Gunter, Marc J., Lu, Y., Cross, Amanda J., Riboli, E., Vineis, P., Aleksandrova, K., Chuang, S.C., Boeing, H., Zuo, Huijuan, Tell, G.S., Pischon, T., Jenab, M., Bueno-De-Mesquita, B., Vollset, S.E., Midttun, Øivind, Ueland, P.M., Fedirko, V., Johansson, M., Weiderpass, E., Severi, G., Racine, A., Boutron-Ruault, M.C., Kaaks, R., Kühn, Tilman, Tjønneland, A., Overvad, K., Quirós, José R., Jakszyn, P., Sánchez, M.-J, Dorronsoro, M., Chirlaque, M.D., Ardanaz, E., Khaw, Kay T., Wareham, Nicholas J., Travis, Ruth C., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Sieri, S., Tumino, R., Panico, S., May, A.M., Palmqvist, R., Ljuslinder, Ingrid, Kong, S.Y.J., Freisling, H., Gunter, Marc J., Lu, Y., Cross, Amanda J., Riboli, E., and Vineis, P.

Published
2015

8. A prospective study of the immune system activation biomarker neopterin and colorectal cancer risk

Author

Aleksandrova, K., Chuang, S.C., Boeing, H., Zuo, Huijuan, Tell, G.S., Pischon, T., Jenab, M., Bueno-De-Mesquita, B., Vollset, S.E., Midttun, Øivind, Ueland, P.M., Fedirko, V., Johansson, M., Weiderpass, E., Severi, G., Racine, A., Boutron-Ruault, M.C., Kaaks, R., Kühn, Tilman, Tjønneland, A., Overvad, K., Quirós, José R., Jakszyn, P., Sánchez, M.-J, Dorronsoro, M., Chirlaque, M.D., Ardanaz, E., Khaw, Kay T., Wareham, Nicholas J., Travis, Ruth C., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Sieri, S., Tumino, R., Panico, S., May, A.M., Palmqvist, R., Ljuslinder, Ingrid, Kong, S.Y.J., Freisling, H., Gunter, Marc J., Lu, Y., Cross, Amanda J., Riboli, E., Vineis, P., Aleksandrova, K., Chuang, S.C., Boeing, H., Zuo, Huijuan, Tell, G.S., Pischon, T., Jenab, M., Bueno-De-Mesquita, B., Vollset, S.E., Midttun, Øivind, Ueland, P.M., Fedirko, V., Johansson, M., Weiderpass, E., Severi, G., Racine, A., Boutron-Ruault, M.C., Kaaks, R., Kühn, Tilman, Tjønneland, A., Overvad, K., Quirós, José R., Jakszyn, P., Sánchez, M.-J, Dorronsoro, M., Chirlaque, M.D., Ardanaz, E., Khaw, Kay T., Wareham, Nicholas J., Travis, Ruth C., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Sieri, S., Tumino, R., Panico, S., May, A.M., Palmqvist, R., Ljuslinder, Ingrid, Kong, S.Y.J., Freisling, H., Gunter, Marc J., Lu, Y., Cross, Amanda J., Riboli, E., and Vineis, P.

Published
2015

9. A prospective study of the immune system activation biomarker neopterin and colorectal cancer risk

Author

Aleksandrova, K., Chuang, S.C., Boeing, H., Zuo, Huijuan, Tell, G.S., Pischon, T., Jenab, M., Bueno-De-Mesquita, B., Vollset, S.E., Midttun, Øivind, Ueland, P.M., Fedirko, V., Johansson, M., Weiderpass, E., Severi, G., Racine, A., Boutron-Ruault, M.C., Kaaks, R., Kühn, Tilman, Tjønneland, A., Overvad, K., Quirós, José R., Jakszyn, P., Sánchez, M.-J, Dorronsoro, M., Chirlaque, M.D., Ardanaz, E., Khaw, Kay T., Wareham, Nicholas J., Travis, Ruth C., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Sieri, S., Tumino, R., Panico, S., May, A.M., Palmqvist, R., Ljuslinder, Ingrid, Kong, S.Y.J., Freisling, H., Gunter, Marc J., Lu, Y., Cross, Amanda J., Riboli, E., Vineis, P., Aleksandrova, K., Chuang, S.C., Boeing, H., Zuo, Huijuan, Tell, G.S., Pischon, T., Jenab, M., Bueno-De-Mesquita, B., Vollset, S.E., Midttun, Øivind, Ueland, P.M., Fedirko, V., Johansson, M., Weiderpass, E., Severi, G., Racine, A., Boutron-Ruault, M.C., Kaaks, R., Kühn, Tilman, Tjønneland, A., Overvad, K., Quirós, José R., Jakszyn, P., Sánchez, M.-J, Dorronsoro, M., Chirlaque, M.D., Ardanaz, E., Khaw, Kay T., Wareham, Nicholas J., Travis, Ruth C., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Sieri, S., Tumino, R., Panico, S., May, A.M., Palmqvist, R., Ljuslinder, Ingrid, Kong, S.Y.J., Freisling, H., Gunter, Marc J., Lu, Y., Cross, Amanda J., Riboli, E., and Vineis, P.

Published
2015

10. A prospective study of the immune system activation biomarker neopterin and colorectal cancer risk

Author

MS MDL 1, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Aleksandrova, K., Chuang, S.C., Boeing, H., Zuo, Huijuan, Tell, G.S., Pischon, T., Jenab, M., Bueno-De-Mesquita, B., Vollset, S.E., Midttun, Øivind, Ueland, P.M., Fedirko, V., Johansson, M., Weiderpass, E., Severi, G., Racine, A., Boutron-Ruault, M.C., Kaaks, R., Kühn, Tilman, Tjønneland, A., Overvad, K., Quirós, José R., Jakszyn, P., Sánchez, M.-J, Dorronsoro, M., Chirlaque, M.D., Ardanaz, E., Khaw, Kay T., Wareham, Nicholas J., Travis, Ruth C., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Sieri, S., Tumino, R., Panico, S., May, A.M., Palmqvist, R., Ljuslinder, Ingrid, Kong, S.Y.J., Freisling, H., Gunter, Marc J., Lu, Y., Cross, Amanda J., Riboli, E., Vineis, P., MS MDL 1, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Aleksandrova, K., Chuang, S.C., Boeing, H., Zuo, Huijuan, Tell, G.S., Pischon, T., Jenab, M., Bueno-De-Mesquita, B., Vollset, S.E., Midttun, Øivind, Ueland, P.M., Fedirko, V., Johansson, M., Weiderpass, E., Severi, G., Racine, A., Boutron-Ruault, M.C., Kaaks, R., Kühn, Tilman, Tjønneland, A., Overvad, K., Quirós, José R., Jakszyn, P., Sánchez, M.-J, Dorronsoro, M., Chirlaque, M.D., Ardanaz, E., Khaw, Kay T., Wareham, Nicholas J., Travis, Ruth C., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Sieri, S., Tumino, R., Panico, S., May, A.M., Palmqvist, R., Ljuslinder, Ingrid, Kong, S.Y.J., Freisling, H., Gunter, Marc J., Lu, Y., Cross, Amanda J., Riboli, E., and Vineis, P.

Published
2015

11. Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3

Author

Purdue, M.P., Johansson, M., Zelenika, D., Toro, J.R., Scelo, G., Moore, L.E., Prokhortchouk, E., Wu, X., Kiemeney, L.A.L.M., Gaborieau, V., Jacobs, K.B., Chow, W.H., Zaridze, D., Matveev, V., Lubinski, J., Trubicka, J., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Bucur, A., Bencko, V., Foretova, L., Janout, V., Boffetta, P., Colt, J.S., Davis, F.G., Schwartz, K.L., Banks, R.E., Selby, P.J., Harnden, P., Berg, C.D., Hsing, A.W., Grubb, R.L. 3rd, Boeing, H., Vineis, P., Clavel-Chapelon, F., Palli, D., Tumino, R., Krogh, V., Panico, S., Duell, E.J., Quiros, J.R., Sanchez, M.J., Navarro, C, Ardanaz, E., Dorronsoro, M., Khaw, K.T., Allen, N.E., Bueno-De-Mesquita, H.B., Peeters, P.H.M., Trichopoulos, D., Linseisen, J., Ljungberg, B, Overvad, K., Tjonneland, A., Romieu, I., Riboli, E., Mukeria, A., Shangina, O., Stevens, V.L., Thun, M.J., Diver, W.R., Gapstur, S.M., Pharoah, P.D., Easton, D.F., Albanes, D., Weinstein, S.J., Virtamo, J., Vatten, L., Hveem, K., Njolstad, I., Tell, G.S., Stoltenberg, C., Kumar, R., Koppova, K., Cussenot, O., Benhamou, S., Oosterwijk, E., Vermeulen, H.H.M., Aben, K.K.H., Marel, S.L. van der, Ye, Y., Wood, C.G., Pu, X., Mazur, A.M., Boulygina, E.S., Chekanov, N.N., Foglio, M., Lechner, D., Gut, I, Heath, S., Blanche, H., Hutchinson, A., Thomas, G., Wang, Z., Yeager, M., Fraumeni, J.F. Jr., Skryabin, K.G., McKay, J.D., Purdue, M.P., Johansson, M., Zelenika, D., Toro, J.R., Scelo, G., Moore, L.E., Prokhortchouk, E., Wu, X., Kiemeney, L.A.L.M., Gaborieau, V., Jacobs, K.B., Chow, W.H., Zaridze, D., Matveev, V., Lubinski, J., Trubicka, J., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Bucur, A., Bencko, V., Foretova, L., Janout, V., Boffetta, P., Colt, J.S., Davis, F.G., Schwartz, K.L., Banks, R.E., Selby, P.J., Harnden, P., Berg, C.D., Hsing, A.W., Grubb, R.L. 3rd, Boeing, H., Vineis, P., Clavel-Chapelon, F., Palli, D., Tumino, R., Krogh, V., Panico, S., Duell, E.J., Quiros, J.R., Sanchez, M.J., Navarro, C, Ardanaz, E., Dorronsoro, M., Khaw, K.T., Allen, N.E., Bueno-De-Mesquita, H.B., Peeters, P.H.M., Trichopoulos, D., Linseisen, J., Ljungberg, B, Overvad, K., Tjonneland, A., Romieu, I., Riboli, E., Mukeria, A., Shangina, O., Stevens, V.L., Thun, M.J., Diver, W.R., Gapstur, S.M., Pharoah, P.D., Easton, D.F., Albanes, D., Weinstein, S.J., Virtamo, J., Vatten, L., Hveem, K., Njolstad, I., Tell, G.S., Stoltenberg, C., Kumar, R., Koppova, K., Cussenot, O., Benhamou, S., Oosterwijk, E., Vermeulen, H.H.M., Aben, K.K.H., Marel, S.L. van der, Ye, Y., Wood, C.G., Pu, X., Mazur, A.M., Boulygina, E.S., Chekanov, N.N., Foglio, M., Lechner, D., Gut, I, Heath, S., Blanche, H., Hutchinson, A., Thomas, G., Wang, Z., Yeager, M., Fraumeni, J.F. Jr., Skryabin, K.G., and McKay, J.D.

Abstract

Contains fulltext : 97937.pdf (publisher's version ) (Closed access), We conducted a two-stage genome-wide association study of renal cell carcinoma (RCC) in 3,772 affected individuals (cases) and 8,505 controls of European background from 11 studies and followed up 6 SNPs in 3 replication studies of 2,198 cases and 4,918 controls. Two loci on the regions of 2p21 and 11q13.3 were associated with RCC susceptibility below genome-wide significance. Two correlated variants (r(2) = 0.99 in controls), rs11894252 (P = 1.8 x 10) and rs7579899 (P = 2.3 x 10), map to EPAS1 on 2p21, which encodes hypoxia-inducible-factor-2 alpha, a transcription factor previously implicated in RCC. The second locus, rs7105934, at 11q13.3, contains no characterized genes (P = 7.8 x 10(1)). In addition, we observed a promising association on 12q24.31 for rs4765623, which maps to SCARB1, the scavenger receptor class B, member 1 gene (P = 2.6 x 10). Our study reports previously unidentified genomic regions associated with RCC risk that may lead to new etiological insights.

Published
2011

12. Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3

Author

Purdue, M.P., Johansson, M., Zelenika, D., Toro, J.R., Scelo, G., Moore, L.E., Prokhortchouk, E., Wu, X., Kiemeney, L.A.L.M., Gaborieau, V., Jacobs, K.B., Chow, W.H., Zaridze, D., Matveev, V., Lubinski, J., Trubicka, J., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Bucur, A., Bencko, V., Foretova, L., Janout, V., Boffetta, P., Colt, J.S., Davis, F.G., Schwartz, K.L., Banks, R.E., Selby, P.J., Harnden, P., Berg, C.D., Hsing, A.W., Grubb, R.L. 3rd, Boeing, H., Vineis, P., Clavel-Chapelon, F., Palli, D., Tumino, R., Krogh, V., Panico, S., Duell, E.J., Quiros, J.R., Sanchez, M.J., Navarro, C, Ardanaz, E., Dorronsoro, M., Khaw, K.T., Allen, N.E., Bueno-De-Mesquita, H.B., Peeters, P.H.M., Trichopoulos, D., Linseisen, J., Ljungberg, B, Overvad, K., Tjonneland, A., Romieu, I., Riboli, E., Mukeria, A., Shangina, O., Stevens, V.L., Thun, M.J., Diver, W.R., Gapstur, S.M., Pharoah, P.D., Easton, D.F., Albanes, D., Weinstein, S.J., Virtamo, J., Vatten, L., Hveem, K., Njolstad, I., Tell, G.S., Stoltenberg, C., Kumar, R., Koppova, K., Cussenot, O., Benhamou, S., Oosterwijk, E., Vermeulen, H.H.M., Aben, K.K.H., Marel, S.L. van der, Ye, Y., Wood, C.G., Pu, X., Mazur, A.M., Boulygina, E.S., Chekanov, N.N., Foglio, M., Lechner, D., Gut, I, Heath, S., Blanche, H., Hutchinson, A., Thomas, G., Wang, Z., Yeager, M., Fraumeni, J.F. Jr., Skryabin, K.G., McKay, J.D., Purdue, M.P., Johansson, M., Zelenika, D., Toro, J.R., Scelo, G., Moore, L.E., Prokhortchouk, E., Wu, X., Kiemeney, L.A.L.M., Gaborieau, V., Jacobs, K.B., Chow, W.H., Zaridze, D., Matveev, V., Lubinski, J., Trubicka, J., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Bucur, A., Bencko, V., Foretova, L., Janout, V., Boffetta, P., Colt, J.S., Davis, F.G., Schwartz, K.L., Banks, R.E., Selby, P.J., Harnden, P., Berg, C.D., Hsing, A.W., Grubb, R.L. 3rd, Boeing, H., Vineis, P., Clavel-Chapelon, F., Palli, D., Tumino, R., Krogh, V., Panico, S., Duell, E.J., Quiros, J.R., Sanchez, M.J., Navarro, C, Ardanaz, E., Dorronsoro, M., Khaw, K.T., Allen, N.E., Bueno-De-Mesquita, H.B., Peeters, P.H.M., Trichopoulos, D., Linseisen, J., Ljungberg, B, Overvad, K., Tjonneland, A., Romieu, I., Riboli, E., Mukeria, A., Shangina, O., Stevens, V.L., Thun, M.J., Diver, W.R., Gapstur, S.M., Pharoah, P.D., Easton, D.F., Albanes, D., Weinstein, S.J., Virtamo, J., Vatten, L., Hveem, K., Njolstad, I., Tell, G.S., Stoltenberg, C., Kumar, R., Koppova, K., Cussenot, O., Benhamou, S., Oosterwijk, E., Vermeulen, H.H.M., Aben, K.K.H., Marel, S.L. van der, Ye, Y., Wood, C.G., Pu, X., Mazur, A.M., Boulygina, E.S., Chekanov, N.N., Foglio, M., Lechner, D., Gut, I, Heath, S., Blanche, H., Hutchinson, A., Thomas, G., Wang, Z., Yeager, M., Fraumeni, J.F. Jr., Skryabin, K.G., and McKay, J.D.

Abstract

Contains fulltext : 97937.pdf (publisher's version ) (Closed access), We conducted a two-stage genome-wide association study of renal cell carcinoma (RCC) in 3,772 affected individuals (cases) and 8,505 controls of European background from 11 studies and followed up 6 SNPs in 3 replication studies of 2,198 cases and 4,918 controls. Two loci on the regions of 2p21 and 11q13.3 were associated with RCC susceptibility below genome-wide significance. Two correlated variants (r(2) = 0.99 in controls), rs11894252 (P = 1.8 x 10) and rs7579899 (P = 2.3 x 10), map to EPAS1 on 2p21, which encodes hypoxia-inducible-factor-2 alpha, a transcription factor previously implicated in RCC. The second locus, rs7105934, at 11q13.3, contains no characterized genes (P = 7.8 x 10(1)). In addition, we observed a promising association on 12q24.31 for rs4765623, which maps to SCARB1, the scavenger receptor class B, member 1 gene (P = 2.6 x 10). Our study reports previously unidentified genomic regions associated with RCC risk that may lead to new etiological insights.

Published
2011

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