23 results on '"Tan, J L"'
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2. BJS commission on surgery and perioperative care post-COVID-19
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Abahuje, E, Abbas, A, Abd El Aziz Abd El Maksoud, M, Abdelhady, A, Abdelhamid, S, Abdelkarem Ahmed Faraj, H, Abdelqader, B, Abdelrahman, T, Abdou, H, Abdullah, A, Abedua Harrison, M, Abem Owusu, E, Aboalazayem, A, Aboulhosn, R, Abu Oda, S, Abubakar, A, Abutaka, A, Acevedo Fontalvo, D, Acuna, S, Adefemi, A, Adegbola, S, Adenuga, T, Adeyeye, A, Adil Hilmi, A, Adisa, A, Aditya, K, Adjeso, T, Aftab, R, Afzal, A, Aggarwal, V, Aggarwal, A, Aguilera, R, Aguilera-Arevalo, M, Aguirre Salamanca, E, Aguirre-Allende, I, Ahari, D, Ahmad, H, Ahmad Rauf, F, Ahmad Zartasht Khan, A, Ahmed, S, Ahmed Fieturi, N, Ahmed Mohamed, S, Ahmed-Bakhsh, Z, Ahsan Javed, M, Akano, L, Akbar, A, Akhbari, M, Akhmedov, P, Aksit, G, Akula, Y, Alagaratnam, A, Al Majid, S, Al Mukhtar, O, Al Omran, H, Alasali, N, Al-Azzawi, M, Al-Habsi, R, Al-Iraqi, H, Al-Naggar, H, Alameer, E, Albirnawi, H, Alderson, D, Aldulaijan, F, Alejandro Miranda Ojeda, R, Alhasan, A, Ali, S, Ali, A, Ali Khan, M, Alimova, Y, Aljanadi, F, Aljubure, R, Allopi, N, Almedbal, H, Almubarak, M, Alqaidoom, Z, Alselaim, N, Alshaar, M, Alshammari, R, Altaf, K, Altiner, S, Altunpak, B, Alvarez Lozada, L, Amal Nahal, E, Amer, A, Amin, K, Aminu, U, Amisi Numbi, N, Amjad, T, Amoah, R, An, Y, Anastasopoulos, N, Andres Urrutia, J, Angarita, F, Angarita, K, Angel Freiria Eiras, M, Antypas, A, Anwar, M, Anwar, H, Apampa, T, Apostolou, K, Aquina, C, Arachchige Adithi Himika Randeni, R, Archila Godinez, M, Arez, O, Arezzo, A, Armonis, P, Arshad, S, Arshad Salman, M, Arshid, A, Arteaga Asensio, P, Arthur, T, Arumuga Jothi, A, Aryo Damara, F, Asensio Gomez, L, Ashcroft, J, Ashraf, S, Asif, A, Atif, M, Attaullah Khan, M, Avellaneda, N, Awad, S, Awadh, M, Axiaq, A, Ayad Mohammed Shuwayyah, A, Ayalew, D, Aytac, E, Azam, F, Azevedo, J, Azhar, B, Aziz, J, Aziz, A, Azzam, A, Baba Ndajiwo, A, Baig, M, Baker, D, Bakko, F, Balachandran, R, Balachandran, G, Balagizi Mudekereza, J, Balai, E, Balci, B, Balduzzi, A, Balhareth, A, Bandyopadhyay, S, Banerjee, D, Bangalore Mahalinga, D, Bankhead-Kendall, B, Bankole, N, Banwell, V, Baris Bengur, F, Baris Ozmen, B, Barnard, M, Barnett, R, Barreras Espinoza, J, Barrios, A, Bass, G, Bass, M, Bausys, A, Bavikatte, A, Bayram, J, Belousov, M, Berardi, A, Beamish, A, Beattie, C, Belia, F, Bellato, V, Bellikatti, S, Benjamens, S, Benlice, C, Bennedsgaard, S, Bennett, S, Bentounsi, Z, Bergenfeldt, H, Bergenfelz, A, Besselink, M, Bhandoria, G, Bhangu, E, Bhatia, M, Bhatti, M, Bilgili, Z, Bislenghi, G, Bisset, C, Biswas, S, Blake, J, Blanco, R, Boccalatte, L, Boden, R, Bojanic, C, Boland, M, Boland, P, Bollen, E, Bonci, E, Boni, L, Booth, A, Booth, R, Borakati, A, Borunda Escudero, G, Bosco, S, Bostrom, P, Botelho De Alencar Ferreira Cruz, P, Bouchagier, K, Bouhuwaish, A, Boutros, M, Boyce, K, Boyle, C, Bradshaw, L, Brandl, A, Brar, A, Brat, G, Brenkman, H, Brennan, C, Brines, C, Brookmyre, A, Brosnan, C, Brouwers, L, Brown, A, Brown, L, Brown, C, Brown, J, Bs, V, Buksh, M, Bunani Emmanuel, M, Burbano, D, Burelli, A, Burke, A, Burke, J, Burlov, N, Burns, A, Burton, O, Butt, A, Buzra Ozkan, B, Cabrera Silva, L, Caicedo, E, Calderbank, T, Cambridge, W, Campelo, G, Can Tatar, O, Carbone, F, Carrano, F, Casallas, D, Casanova Portoles, D, Casciani, F, Cassimjee, I, Castaneda Ramirez, O, Catalan, V, Caviedes, J, Cayetano, L, Ceresoli, M, Chan, M, Chan, V, Chandrasinghe, P, Chapman, S, Chaturvedi, A, Chaudhry, D, Chaudry, H, Chen, H, Cheng, A, Chernykh, M, Cherrie, A, Cheruiyot, I, Cheung, J, Chia, C, Chica, J, Chinai, N, Chirwa, A, Chiwaligo, J, Choi, A, Choi, J, Chowdhury, M, Christopher, E, Christou, N, Chu, T, Chua, D, Chua, H, Chung, C, Cihat Yildirim, A, Cillo, M, Cioffi, S, Claireaux, H, Clermonts, S, Clifford, R, Climent, M, Clynch, A, Coelen, R, Colas-Ruiz, E, Collar, A, Collard, M, Conlon, K, Connelly, T, Connor, K, Cook, J, Correia De Sa, T, Cosgun Acar, N, Costa, T, Couch, D, Cowper, S, Creavin, B, Crook, B, Curell, A, D'Alessio, R, Dale, J, Damgaard Eriksen, J, Dario Martin Gonzalez, I, Darwish, A, Das, M, Das, R, Das, K, Dave, R, David, S, Davies, T, Davis, C, Davison, S, Davletshina, V, Dawidziuk, A, Dawson, A, De Andres Crespo, M, De Berker, H, De Dieu Ngo, P, Dekker, E, De La Caridad Espinosa Luis, R, De Lacy, B, Demartines, N, De Montserrat Medina Sifuentes, A, De Silva, S, Del Rio, C, Delaune, V, Dell, A, Demirbas, I, Demirli Atici, S, Deniz Tepe, M, Derebey, M, Desai, G, Desai, M, Devarakonda, S, Deveras, N, Di Franco, G, Di Martino, M, Di Marzo, F, Diaz, A, Diaz Del Gobbo, G, Diazcastrillon, C, Dick, L, Dickinson, K, Diego, E, Dimasi, I, Ding, A, Dingemans, S, Dixon, L, Dixon, B, Doherty, W, Dooreemeah, D, Donohue, C, Dornseifer, M, Dossa, F, Dossou, W, Drake, T, Drami, I, Drevin, G, Du Plessis, M, Dudi-Venkata, N, Dudley, R, Duffy, S, Duklas, D, Dumbrava, B, Duygu Avlar, F, Dworzynska, A, Ebrahim, W, Ebrahim, A, Efren Lozada Hernandez, E, Ehigie, N, El Boghdady, M, El Hasnaoui, C, El Sheikh, M, El-Hussuna, A, Eldurssi, O, Elfeki, H, Elhadi, M, Elhassan, M, Elhissi, A, Elliot, B, Elsenbroek, C, Elsolh, B, Elson, N, Eltyeb, H, Emerson, H, Emile, S, Endalle, G, English, W, Ercisli, C, Espinosa, G, Essam Abdelraheem, M, Essangri, H, Etienne, P, Evans, M, Evans, T, Ezeme, C, Ezzahraa, F, Fadalla, T, Fagan, J, Fahmy, M, Fairfield, C, Falade, O, Famularo, S, Faqar-Uz-Zaman, F, Farid, Y, Farooq, A, Farooq, H, Farooqui, F, Farquharson, B, Faruqi, A, Faulder, R, Faut, M, Fechner, K, Feenstra, T, Fehervari, M, Fernandez, L, Fernandez Alberti, J, Ferrario, L, Field, D, Fiore, L, Fingerhut, S, Finlayson, S, Fleming, N, Fleming, C, Florial, E, Fok, M, Fokin, D, Foley, M, Forero, M, Forgan, T, Fornasiero, M, Fowler, H, Fowler, G, Franchi, E, Franklin, L, Fredriksson, A, Fruhling, P, Fuentes Navarrette, G, Fulop, A, Furtado, M, Gaarder, T, Galbraith, N, Gallagher, I, Gallo, G, Gana, T, Gaskin, E, Gasparini, M, Gatan, R, Geary, E, Gelaye Wudineh, K, Gemenetzis, G, Georgi, M, Ghalige, H, Ghareeb, W, Ghatwary Tantawy, T, Ghomsi, C, Ghuman, A, Giannakis, P, Giron, F, Gjengedal, K, Gkotsis, E, Glasbey, J, Godahewa, S, Godula, D, Goffredo, P, Goh, S, Golriz, M, Gomez, L, Gomez Gomez, D, Gonzalez, R, Gonzalez, D, Gonzalez Gutierrez, E, Gopar, D, Gordini, L, Gori, A, Gortazar, S, Gousy, N, Gowda, R, Gowda, M, Gqada, J, Grechenig, M, Greer, J, Gregorio, L, Grigorova, A, Grimes, H, Groot, V, Grossman, R, Gruber, R, Gruter, A, Guest, R, Gujjuri, R, Gulcek, E, Gulcu, B, Gull, K, Gulmez, M, Gupta, V, Gutlic, A, Guven, T, Gwatirisa, T, Gwini, G, Gwodog, P, Gysling, S, Habib, M, Hafeez Bhatti, A, Hallesmith, J, Halloran, S, Hamza Sadiq, M, Haney, C, Hanna, N, Hanna, L, Hannington, M, Harbjerg, J, Haribaskaran, D, Harran, N, Harrington, B, Harrison, E, Hasan, R, Hashmi, S, Hassan, M, Hassan, A, Haverkamp, L, Hazen, S, Heer, B, Heil, J, Helliwell, J, Henriksen, N, Henshall, D, Hermanson, M, Hermena, S, Hettiarachchi, D, Hextall, C, Hidalgo, M, Hidayat, H, Hider, A, Higgins, P, Hinchliffe, R, Hirani, D, Hirpara, D, Hisham, I, Hite, M, Hoh, S, Holmberg, C, Holmich, E, Holst, F, Hossam, A, Hossam Elfallal, A, Howard, P, Huaman, E, Huang, Y, Huang, L, Huang, D, Huber, T, Hugh, J, Hughes, J, Huttner, F, Huynh, R, Hylands, A, Iannuzzi, J, Ielpo, B, Iftikhar Talib, A, Ignacio, J, Ignatavicius, P, Ike, S, Ikwu, C, Inama, M, Ing, A, Ingels, A, Isik, A, Islam, N, Ives, I, Al-Hasan, A, Perez Rivera, C, Jacome, F, Jaffer, T, Jagiella-Lodise, O, Jain, M, Jain, K, Jakubauskas, M, Jalal, M, James, H, Jang, Y, Janssen, B, Jansson, H, Jariod-Ferrer, U, Javanmard, H, Javed, S, Jayarajah, U, Jayasuriya, I, Je, J, Jessop, Z, Jia Lin Tang, E, Jiang, H, Jiayan, Y, Jih Huei, T, Jimenez-Rodriguez, R, Joh, D, Johnson, A, Jones, N, Jones, C, Jordan, C, Jose Nunez Ju, J, Jose Pizarro, M, Jose Salazar, C, Joseph, J, Justiniano, C, Kabir, T, Kadhum, M, Kalfountzos, C, Kalogiannaki, E, Kalyanasundaram, K, Kamarajah, S, Kamil Quraishi, M, Kanemitsu, Y, Kapila, A, Kapila, V, Karagiannidis, G, Kashif, M, Kathiravelupillai, S, Kathiravelupillai, A, Katsogridakis, E, Kaur, K, Kaur Sekhon Inderjit Singh, H, Kausur, N, Kawka, M, Keehan, G, Kehlet Watt, S, Kelly, M, Kelvin Egbuchulem, I, Kembuan, G, Khajeh, E, Khaled Elfaitur, A, Khan, M, Khan, S, Khan, D, Khan, H, Khatkar, H, Khatkov, E, Khaw, R, Kim, B, Kishore Siddiraju, K, Kitua, D, Kirimtay, B, Kmezic, S, Knight, S, Koeter, T, Koh, A, Koh Hong Xiang, F, Kojo Anyomih, T, Kok, A, Kokelaar, R, Koliarakis, I, Kolli, S, Kong, J, Konig, D, Koshy, M, Kotze, P, Kourdouli, A, Kowal, M, Kraima, A, Kramer, F, Kryzauskas, M, Kuchynskyi, I, Kuemmerli, C, Kuiper, S, Kumar, S, Kumar, A, Kumar, L, Kumar, H, Kumar, N, Kumar Bandyopadhyay, S, Kumar Garg, P, Kumar Venkatappa, S, Kung, J, Kural, S, Kushairi, A, Kuuzie, E, Kvietkauskas, M, Kwek, I, La, J, Lai, L, Lakpriya, S, Lam, K, Lami, M, Lansdorp-Vogelaar, I, Lapolla, P, Larsen, H, Latif, J, Laudari, U, Laurnezi, A, Lawal, A, Lawday, S, Lederhuber, H, Lednev, A, Lee, R, Van Leerdam, M, Lefevbre, G, Lesmus, M, Leyva Moraga, F, Leyva Moraga, E, Li, H, Li, A, Li, Z, Licardie, E, Light, A, Lightner, A, Lin, A, Lincango, E, Litta, F, Liu, H, Lofthouse, B, Londono, M, Lopes, R, Lopes De Freitas, R, Lopez, L, Lopez, A, Lopez-Gomez, J, Lopez-Pena, G, Lowe, R, Lowe, D, Lowey, M, Loy, G, Lozanovski, V, Luzon, J, Lynn, P, Maccabe, T, Machielsen, A, Mafla Herreria, C, Maggino, L, Mahawar, K, Mahmood, D, Mahmoud, M, Mahtani, K, Maitra, I, Maji, S, Majiet, I, Mal, L, Malherbe, J, Malhotra, K, Malkomes, P, Man, E, Manan Sheikh, A, Manjunath, S, Manzano Nunez, R, Manzoor, S, Maqsood, R, Marchegiani, G, Marchegiani, F, Marin, D, Marin, A, Marks, I, Marson, E, Martensen, A, Martin, D, Martin Martin, G, Martin-Perez, B, Martinez, P, Marwaha, P, Mashauri, C, Mashbari, H, Masior, L, Masri, R, Masud, L, Masudi, S, Mateu Calabuig, G, Math, S, Matrachisia, A, Mayol, J, Mazingi, D, Mazzotta, A, Mcalinden, J, Mccabe, G, Mccolm, L, Mcelvaney, H, Mcgivern, K, Mcgovern, J, Mcguinness, E, Mcinerney, N, Mckay, S, Mckee, C, Mckenna, M, Mckenna, N, Mclean, K, Mediratta, S, Medkova, Y, Medzhidov, O, Mehraj, A, Mekhael, M, Mekinde, O, Mellenthin, C, Melucci, A, Mentor, K, Merchant, J, Messias, H, Messeha, M, Meza, C, Mhango, P, Miladinov, M, Milagros Niquen Jimenez, M, Miller, P, Mills, E, Milton, A, Minayeva, O, MinHua Zheng, Z, Mischlinger, H, Mockli, B, Modi, R, Mohamed, H, Mohamed, M, Mohamed Abulghasm, T, Mohammad, S, Mohammed, T, Mohammed, A, Mohan, H, Mohan, M, Moin, I, Mok, V, Molina, G, Moloney, J, Moneim, J, Monfort Mira, M, Montcusi Ventura, B, Montouri, M, Moossdorff, M, Mora-Guzman, I, Moran, B, Moran, R, Moreno-Ordaz, S, Morera, A, Morgan, R, Morley, R, Moro-Valdezate, D, Moros, S, Moss, J, Morven, A, Morton, D, Moynihan, A, Moyon, M, Muduli, N, Mugla, N, Mugla, W, Muller, P, Mun, G, Mundhada, R, Munir, I, Munoz, F, Munoz, E, Munoz, A, Munoz Balderas, D, Murgitroyd, E, Murray, V, Murthy, S, Mushiwokufa, W, Mustafa, H, Mustakimov, B, Mutambanengwe, P, Myint, P, Nadkarni, S, Naess, P, Nahar, S, Naidoo, P, Nam, R, Nandhra, S, Nanjappa, N, Narasimhan, V, Nardi, W, Nasir, M, Naughton, A, Naumann, D, Navarro, S, Nawaaz Karimbocus, M, Nazir, A, Ndereya, S, Ndong, A, Negoi, I, Nel, D, Nelson, D, Nepal, S, Nugent, T, Nepogodiev, D, Neufeld, J, Ng, J, Ng, D, Ng, C, Ngaserin, S, Ngu, L, Ngwenya, E, Fhearaigh, R, Nikolousakis, T, Ninkovic, M, Nita, G, Nitschke, C, Noren, E, Noton, T, Novikova, A, Nowinka, Z, Nyakunengwa, T, Nyalundja, A, Nzenwa, I, Kristensen, H, O'Brien, C, O'Brien, L, O'Brien, S, O'Reilly, J, O'Rourke, S, O'Sullivan, M, O'Dwyer, M, Ochieng, L, Oderoha, E, Oh, K, Ohlberger, L, Olcum, M, Olkina, A, Omkumar, M, Omnitel, B, Oncel Yakar, D, Ong, K, Ong Wei Lin, L, Ooi, R, Ooi, S, Oomman, A, Oon Tyjet, D, Opiyo, S, Oscullo Yepez, J, Osei-Kuffour, N, Osunronbi, T, Ottlakan, A, Oussama Kacimi, S, Ovaere, S, Ozair, A, Pachler, F, Pai Oo, S, Paiella, S, Panaiotti, L, Panda, N, Pandarinath, S, Pandey, D, Pandrowala, S, Papa Mamadou, F, Paranathala, M, Park, J, Parmar, C, Parvez, A, Pasovic, L, Pasquer, A, Pasumarthy, N, Pata, F, Patel, T, Patel, P, Patel, N, Patel, M, Patron Uriburu, N, Patrone, R, Paul, A, Pavan Kumar, O, Pavithran, A, Pedraza Ciro, M, Pellino, G, Peloso, A, Pena Gallardo, M, Pena Velazquez, A, Perea, J, Perez-Sanchez, L, Perra, T, Perrotta, G, Petersson, P, Petra, G, Petrucciani, N, Pickin, C, Pino, V, Pinotti, E, Pinto, F, Plum, P, Podesta, F, Pollini, T, Pompeu Sa, M, Ponce Leon, F, Ponniah, H, Ponte De Sousa, X, Ponton, J, Pontula, A, Popa, M, Portilla, A, Posner, F, Post, S, Potolicchio, A, Pouwels, S, Povo, A, Prasad, P, Preciado, S, Preece, R, Proud, D, Pulido Segura, J, Puliyath, N, Qui, M, Quimbaya Rodriguez, A, Raby-Smith, W, Racovita, A, Rad, A, Radwan, R, Rafaih Iqbal, M, Rafik, A, Raguan, B, Rahi, M, Rahiri, J, Rahme, J, Rai, L, Raj, A, Raj Saksena, A, Raja, M, Ramirez, J, Ramzi, J, Ranstam, J, Rao, C, Rashid, A, Ratnayake, B, Rattanasirivilai, K, Raubenheimer, K, Ravikumar, N, Ravn, S, Razoz, N, Rea, W, Regan, A, Rela, M, Remme, A, Rey Chaves, C, Reyes, A, Riad, A, Rice, D, Rios Quintana, K, Ritter, A, Roalso, M, Robinson, D, Rodriguez, J, Rodriguez, F, Rodriguez, M, Rogers, A, Rohila, J, Romanyuc, D, Romic, I, Rommaneh, M, Rompianesi, G, Rosa, F, Roscio, F, Rose, A, Rotimi, T, Ruiz, H, Ruiz Yucuma, J, Ruiz-Ucar, E, Ruslan, M, Rutegard, M, Ryan Harper, E, Ryckx, A, Rydbeck, D, Sa-Marta, E, Sadien, I, Safari Nteranya, D, Sagoo, K, Sakata, S, Saladino, E, Saleem, A, Saleem, S, Salehi, M, Salih, S, Sallinen, V, Salvans, S, Sam, Z, Samadov, E, Sampaio Alves, M, Sanad, A, Sanchez Fonseca, S, Sanchez Teran, A, Sanchez Ussa, S, Sandli, O, Sanfey, H, Sanghera, J, Sani, I, Santafe Guerrero, M, Sante Fornasiero, M, Santes Jasso, O, Santos Pereira, I, Santos Sousa, H, Saratzis, A, Sarmiento Alarcon, A, Saumtally, T, Sayyed, R, Schettino, M, Schleimer, L, Schmidt, T, Schondffelt, K, Schwab, M, Scott, A, Searle, H, Sebopelo, L, Seeglier, B, Seishima, R, Semenvov, D, Senent-Boza, A, Sepulveda, J, Serenari, M, Serrano Navidad, M, Sert, I, Sewart, E, Sgro, A, Shadrina, V, Shah, K, Shahid, F, Shalaby, M, Shankar, B, Shapiro, J, Sharma, L, Sheel, A, Shenfine, A, Shenoy, S, Sherif, A, Shetty, N, Shetty, R, Sia, T, Sichimba, D, Siddique, H, Siddiqui, I, Simkens, G, Simoe, J, Simon, H, Sinan, L, Singh, T, Singh, K, Singh, Y, Sinha, L, Siragusa, L, Sluckin, T, Smart, Y, Smith, H, Smith, K, Smits, L, Sneep-Van Kessel, C, Sohrabi, C, Solorzano Pineda, O, Soma, A, Sooriyapiragasam, L, Soreide, K, Sparavigna, M, Spence, R, Spencer, N, Spiers, H, Spinelli, A, Sprakel, J, Sravanam, S, Srinivasan, M, Srinivasan, R, Staniszewska, A, Stanworth, S, Stasinos, K, Steele, R, Steinholt, I, Steinruecke, M, Stephen, B, Stijns, J, Still, M, Stupalkowska, W, Subba, S, Subbotin, V, Sucharitkul, P, Sudarsanam, A, Sudhamsh Reddy, D, Suhardja, T, Suliman, M, Sund, M, Sunilkumar, A, Suresh, N, Sussmes, S, Sutton, P, Syltern, J, Taha, A, Takamizawa, Y, Takoutsing Dongmo, A, Tamas, T, Tan, L, Tan, J, Tan, K, Tan, E, Tan Yong Hui, A, Tanase, A, Tariverdiev, A, Tasnem, A, Tatar, C, Tay, E, Tejedor, P, Tesfaye, G, Tetinou, F, Thorpe, C, Thyo, A, Tlelo Amastal, D, Tolani, M, Tolga Saracoglu, K, Tolgyes, T, Tong, J, Torrent Jansa, L, Toscano Igartua, S, Tovani Palone, M, Traff, H, Trevis, J, Tummers, W, Tur, A, Turchenko, I, Uche, V, Uddin, A, Udonsak, N, Ullah, M, Urbonas, T, Uwins, C, Uy Magadia, E, Uzair Qureshi, A, Uzun, K, Vadim, P, Valarche, G, Valdez Gonzalez, R, Vallee, M, Van Beek, D, Van Dalen, A, Van Den Hondel, D, Van Der Stok, E, Van Dorp, M, Van Oostendorp, S, Van Praag, E, Van Rees, J, Van Silfhout, L, Varga, Z, Varghese, S, Varghese, C, Varghese, J, Vasilica, A, Vasquez Ojeda, X, Vega, E, Vehler, S, Venchiarutti, R, Vengatesan, S, Venn, M, Verma, D, Vianey Partida Nava, G, Victoria, D, Vieira, P, Vilar Alvarez, M, Vinci, D, Viscasillas Pallas, G, Viswanath, M, Vivanco, J, Vizcaya Rodriguez, V, Vo, J, Volchanski, D, Voron, T, Voronovskyi, Y, Vu, J, Wadhwa, M, Wadhwa, S, Wagner, G, Wallace, M, Wang, Y, Wang, J, Wani, A, Wanigasooriya, K, Wanjara, S, Wanjiku, N, Warner, C, Wei Leow, T, Weiser, T, Weisters, M, Wellington, M, Wells, C, Wenzelberg, C, Wettstein, D, Wezel, A, Wheldon, L, Widmer, L, Wilson, M, Wigmore, S, Wijayaratne, T, Wijeyaratne, M, Wijnhoven, B, Wilkin, R, Williams, E, Willis, F, Winter, D, Wirsik, M, Wishah, B, Wong, G, Wong, W, Wong, K, Worku, D, Wright, E, Wright, J, Wroe Wright, O, Xenacki, S, Xia, W, Xu, W, Xu, Z, Yalcinkaya, A, Yang, W, Yang, P, Yanishev, A, Yanzon De La Torre, A, Yao, H, Yaqoob, E, Yen Ling Quake, S, Yeo, D, Yeom, B, Yershov, D, Yiasemidou, M, Yildiz, A, Yiu, A, Yoav, M, Yong, E, Yoshimura, R, Younis, M, Younis Ringshawl, Z, Youssef, M, Yue, Y, Yuen, S, Yuldashev, R, Yurttas, C, Yves, B, Zaborowski, A, Zackeri, R, Zafar, A, Zahra, W, Zaidi, A, Zainudin, S, Zakeri, R, Zamora, I, Zamora, A, Zawistowski, M, Zbikowska, G, Zegers, W, Zehra, S, Zeyra, A, Zhagniyev, Z, Zhukova, L, Zivanovic, M, Zmuc, J, Zope, M, Zubayraeva, A, Zucker, B, Abahuje E., Abbas A., Abd El Aziz Abd El Maksoud M., Abdelhady A., Abdelhamid S., Abdelkarem Ahmed Faraj H., Abdelqader B., Abdelrahman T., Abdou H., Abdullah A., Abedua Harrison M., Abem Owusu E., Aboalazayem A., Aboulhosn R., Abu Oda S., Abubakar A., Abutaka A., Acevedo Fontalvo D., Acuna S., Adefemi A., Adegbola S., Adenuga T., Adeyeye A., Adil Hilmi A., Adisa A., Aditya K., Adjeso T., Aftab R., Afzal A., Aggarwal V., Aggarwal A., Aguilera R., Aguilera-Arevalo M. -L., Aguirre Salamanca E. J., Aguirre-Allende I., Ahari D., Ahmad H., Ahmad Rauf F., Ahmad Zartasht Khan A., Ahmed S., Ahmed Fieturi N., Ahmed Mohamed S., Ahmed-Bakhsh Z., Ahsan Javed M., Akano L., Akbar A., Akhbari M., Akhmedov P., Aksit G., Akula Y., Alagaratnam A. S., Al Majid S., Al Mukhtar O., Al Omran H., AlAsali N., Al-Azzawi M., Al-Habsi R., Al-Iraqi H., Al-Naggar H., Alameer E., Albirnawi H., Alderson D., Aldulaijan F., Alejandro Miranda Ojeda R., AlHasan A., Ali S., Ali A., Ali Khan M., Alimova Y., Aljanadi F., Aljubure R., Allopi N., Almedbal H., Almubarak M., Alqaidoom Z., Alselaim N., Alshaar M., Alshammari R., Altaf K., Altiner S., Altunpak B., Alvarez Lozada L. A., Amal Nahal E., Amer A., Amin K., Aminu U., Amisi Numbi N., Amjad T., Amoah R., An Y., Anastasopoulos N. -A., Andres Urrutia J., Angarita F., Angarita K. -L., Angel Freiria Eiras M., Antypas A., Anwar M. A., Anwar H., Apampa T. O., Apostolou K., Aquina C., Arachchige Adithi Himika Randeni R., Archila Godinez M. I., Arez O., Arezzo A. A., Armonis P., Arshad S., Arshad Salman M., Arshid A., Arteaga Asensio P. C., Arthur T., Arumuga Jothi A., Aryo Damara F., Asensio Gomez L., Ashcroft J., Ashraf S., Asif A., Atif M., Attaullah Khan M., Avellaneda N., Awad S., Awadh M., Axiaq A., Ayad Mohammed Shuwayyah A., Ayalew D., Aytac E., Azam F., Azevedo J., Azhar B., Aziz J., Aziz A., Azzam A., Baba Ndajiwo A., Baig M., Baker D., Bakko F., Balachandran R., Balachandran G., Balagizi Mudekereza J., Balai E., Balci B., Balduzzi A., Balhareth A., Bandyopadhyay S., Banerjee D., Bangalore Mahalinga D., Bankhead-Kendall B., Bankole N. D. A., Banwell V., Baris Bengur F., Baris Ozmen B., Barnard M., Barnett R., Barreras Espinoza J. A., Barrios A., Bass G., Bass M., Bausys A., Bavikatte A., Bayram J., Belousov M., Berardi A. G., Beamish A., Beattie C., Belia F., Bellato V., Bellikatti S., Benjamens S., Benlice C., Bennedsgaard S., Bennett S., Bentounsi Z., Bergenfeldt H., Bergenfelz A., Besselink M., Bhandoria G., Bhangu E., Bhatia M., Bhatti M. T., Bilgili Z., Bislenghi G., Bisset C., Biswas S., Blake J., Blanco R., Boccalatte L., Boden R., Bojanic C., Boland M., Boland P., Bollen E., Bonci E. -A., Boni L., Booth A., Booth R., Borakati A., Borunda Escudero G. E., Bosco S. J., Bostrom P., Botelho De Alencar Ferreira Cruz P., Bouchagier K., Bouhuwaish A., Boutros M., Boyce K., Boyle C., Bradshaw L., Brandl A., Brar A., Brat G., Brenkman H., Brennan C., Brines C., Brookmyre A., Brosnan C., Brouwers L., Brown A., Brown L., Brown C., Brown J., Bs V., Buksh M., Bunani Emmanuel M., Burbano D., Burelli A., Burke A., Burke J., Burlov N., Burns A., Burton O., Butt A., Buzra Ozkan B., Cabrera Silva L., Caicedo E. Y., Calderbank T., Cambridge W., Campelo G., Can Tatar O., Carbone F., Carrano F., Casallas D., Casanova Portoles D., Casciani F., Cassimjee I., Castaneda Ramirez O. A., Catalan V., Caviedes J., Cayetano L., Ceresoli M., Chan M., Chan V., Chandrasinghe P., Chapman S., Chaturvedi A., Chaudhry D., Chaudry H., Chen H. W., Cheng A., Chernykh M., Cherrie A. M., Cheruiyot I., Cheung J., Chia C., Chica J., Chinai N., Chirwa A., Chiwaligo J., Choi A., Choi J., Chowdhury M. R., Christopher E., Christou N., Chu T., Chua D., Chua H. W., Chung C., Cihat Yildirim A., Cillo M., Cioffi S., Claireaux H., Clermonts S., Clifford R., Climent M., Clynch A., Coelen R. -J., Colas-Ruiz E., Collar A., Collard M., Conlon K. C., Connelly T., Connor K., Cook J. A., Correia De Sa T., Cosgun Acar N., Costa T., Couch D., Cowper S., Creavin B., Crook B., Curell A., D'Alessio R., Dale J., Damgaard Eriksen J., Dario Martin Gonzalez I., Darwish A., Das M., Das R., Das K., Dave R., David S. O., Davies T., Davis C., Davison S., Davletshina V., Dawidziuk A., Dawson A., De Andres Crespo M., De Berker H., De Dieu Ngo P., Dekker E., De La Caridad Espinosa Luis R., De Lacy B., Demartines N., De Montserrat Medina Sifuentes A., De Silva S., Del Rio C., Delaune V., Dell A., Demirbas I., Demirli Atici S., Deniz Tepe M., Derebey M., Desai G., Desai M., Devarakonda S., Deveras N., Di Franco G., Di Martino M., Di Marzo F., Diaz A., Diaz Del Gobbo G., DiazCastrillon C., Dick L., Dickinson K., Diego E., Dimasi I., Ding A., Dingemans S., Dixon L., Dixon B., Doherty W., Dooreemeah D., Donohue C., Dornseifer M., Dossa F., Dossou W., Drake T., Drami I., Drevin G., Du Plessis M. C., Dudi-Venkata N., Dudley R., Duffy S., Duklas D., Dumbrava B. -D., Duygu Avlar F., Dworzynska A., Ebrahim W., Ebrahim A., Efren Lozada Hernandez E., Ehigie N., El Boghdady M., El Hasnaoui C., El Sheikh M., El-Hussuna A., Eldurssi O., Elfeki H., Elhadi M., Elhassan M., Elhissi A., Elliot B., Elsenbroek C., Elsolh B., Elson N., Eltyeb H., Emerson H., Emile S. H., Endalle G., English W., Ercisli C., Espinosa G., Essam Abdelraheem M., Essangri H., Etienne P., Evans M. D., Evans T., Ezeme C., Ezzahraa F., Fadalla T., Fagan J., Fahmy M., Fairfield C., Falade O., Famularo S., Faqar-Uz-Zaman F., Farid Y., Farooq A., Farooq H., Farooqui F., Farquharson B., Faruqi A., Faulder R., Faut M., Fechner K., Feenstra T., Fehervari M., Fernandez L., Fernandez Alberti J., Ferrario L., Field D., Fiore L., Fingerhut S., Finlayson S., Fleming N., Fleming C., Florial E., Fok M., Fokin D., Foley M., Forero M. P., Forgan T., Fornasiero M., Fowler H., Fowler G., Franchi E., Franklin L., Fredriksson A., Fruhling P., Fuentes Navarrette G., Fulop A., Furtado M., Gaarder T., Galbraith N., Gallagher I. T. K., Gallo G., Gana T., Gaskin E., Gasparini M., Gatan R. G., Geary E., Gelaye Wudineh K., Gemenetzis G., Georgi M., Ghalige H., Ghareeb W., Ghatwary Tantawy T., Ghomsi C., Ghuman A., Giannakis P., Giron F., Gjengedal K., Gkotsis E., Glasbey J., Godahewa S., Godula D., Goffredo P., Goh S., Golriz M., Gomez L., Gomez Gomez D., Gonzalez R., Gonzalez D., Gonzalez Gutierrez E., Gopar D., Gordini L., Gori A., Gortazar S., Gousy N., Gowda R., Gowda M., Gqada J., Grechenig M., Greer J., Gregorio L., Grigorova A., Grimes H., Groot V., Grossman R. C., Gruber R., Gruter A., Guest R., Gujjuri R., Gulcek E., Gulcu B., Gull K., Gulmez M., Gupta V., Gutlic A., Guven T., Gwatirisa T., Gwini G., Gwodog P., Gysling S., Habib M., Hafeez Bhatti A. B., Hallesmith J., Halloran S., Hamza Sadiq M., Haney C., Hanna N., Hanna L., Hannington M., Harbjerg J., Haribaskaran D., Harran N., Harrington B., Harrison E., Hasan R., Hashmi S., Hassan M., Hassan A., Haverkamp L., Hazen S., Heer B., Heil J., Helliwell J., Henriksen N., Henshall D., Hermanson M., Hermena S., Hettiarachchi D., Hextall C., Hidalgo M., Hidayat H., Hider A., Higgins P., Hinchliffe R., Hirani D., Hirpara D., Hisham I., Hite M., Hoh S. M., Holmberg C., Holmich E., Holst F., Hossam A., Hossam Elfallal A., Howard P., Huaman E., Huang Y., Huang L., Huang D., Huber T., Hugh J., Hughes J., Huttner F., Huynh R., Hylands A., Iannuzzi J., Ielpo B., Iftikhar Talib A., Ignacio J., Ignatavicius P., Ike S., Ikwu C., Inama M., Ing A., Ingels A., Isik A., Islam N., Ives I. J., Al-Hasan A. J. M. S., Perez Rivera C. 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F., Khan S., Khan M., Khan D., Khan H., Khatkar H., Khatkov E., Khaw R., Kim B., Kishore Siddiraju K., Kitua D., Kirimtay B., Kmezic S., Knight S., Koeter T., Koh A., Koh Hong Xiang F., Kojo Anyomih T., Kok A. I. N., Kokelaar R., Koliarakis I., Kolli S., Kong J., Konig D., Koshy M., Kotze P., Kourdouli A., Kowal M., Kraima A., Kramer F., Kryzauskas M., Kuchynskyi I., Kuemmerli C., Kuiper S., Kumar S., Kumar A., Kumar L., Kumar H., Kumar N., Kumar Bandyopadhyay S., Kumar Garg P., Kumar Venkatappa S., Kung J., Kural S., Kushairi A., Kuuzie E., Kvietkauskas M., Kwek I., La J., Lai L., Lakpriya S., Lam K., Lami M., Lansdorp-Vogelaar I., Lapolla P., Larsen H., Latif J., Laudari U., Laurnezi A., Lawal A., Lawday S., Lederhuber H., Lednev A., Lee R., Van Leerdam M. E., Lefevbre G., Lesmus M., Leyva Moraga F. A., Leyva Moraga E., Leyva Moraga F., Li H. L., Li A., Li Z., Licardie E., Light A., Lightner A. L., Lin A., Lincango E., Litta F., Liu H., Lofthouse B., Londono M. A., Lopes R., Lopes De Freitas R., Lopez L., Lopez A. I., Lopez-Gomez J., Lopez-Pena G., Lowe R., Lowe D., Lowey M., Loy G., Lozanovski V., Luzon J., Lynn P., MacCabe T., MacHielsen A., Mafla Herreria C. A., Maggino L., Mahawar K., Mahmood D., Mahmoud M., Mahtani K., Maitra I., Maji S., Majiet I., Mal L., Malherbe J., Malhotra K., Malkomes P., Man E., Manan Sheikh A., Manjunath S., Manzano Nunez R., Manzoor S., Maqsood R., Marchegiani G., Marchegiani F., Marin D., Marin A., Marks I., Marson E., Martensen A., Martin D., Martin Martin G., Martin-Perez B., Martinez P., Marwaha P., Mashauri C., Mashbari H., Masior L., Masri R., Masud L., Masudi S., Mateu Calabuig G., Math S., Matrachisia A., Mayol J., Mazingi D., Mazzotta A., McAlinden J., McCabe G., McColm L., McElvaney H., McGivern K., McGovern J., McGuinness E., McInerney N., McKay S., McKee C., McKenna M., McKenna N., McLean K., Mediratta S., Medkova Y., Medzhidov O., Mehraj A., Mekhael M., Mekinde O., Mellenthin C., Melucci A., Mentor K., Merchant J., Messias H., Messeha M., Meza C., Mhango P., Miladinov M., Milagros Niquen Jimenez M., Miller P., Mills E., Milton A., Minayeva O. A., MinHua Zheng Z., Mischlinger H., Mockli B., Modi R., Mohamed H. M., Mohamed M., Mohamed Abulghasm T., Mohammad S. A., Mohammed T. O., Mohammed A., Mohan H., Mohan M., Moin I., Mok V., Molina G., Moloney J., Moneim J., Monfort Mira M., Montcusi Ventura B., Montouri M., Moossdorff M., Mora-Guzman I., Moran B., Moran R. A. R., Moreno-Ordaz S., Morera A., Morgan R., Morley R., Moro-Valdezate D., Moros S., Moss J. -L., Morven A., Morton D., Moynihan A., Moyon M., Muduli N., Mugla N., Mugla W., Muller P., Mun G., Mundhada R., Munir I., Munoz F., Munoz E., Munoz A., Munoz Balderas D. C., Murgitroyd E., Murray V., Murthy S., Mushiwokufa W., Mustafa H., Mustakimov B., Mutambanengwe P., Myint P., Nadkarni S., Naess P. A., Nahar S., Naidoo P., Nam R., Nandhra S., Nanjappa N., Narasimhan V., Nardi W., Nasir M., Naughton A., Naumann D., Navarro S., Nawaaz Karimbocus M., Nazir A., Ndereya S., Ndong A., Negoi I., Nel D., Nelson D., Nepal S., Nugent T., Nepogodiev D., Neufeld J., Ng J., Ng D., Ng C. E., Ngaserin S., Ngu L., Ngwenya E., Fhearaigh R. N., Nikolousakis T. -K., Ninkovic M., Nita G., Nitschke C., Noren E., Noton T., Novikova A., Nowinka Z., Nyakunengwa T., Nyalundja A., Nzenwa I., Kristensen H. O., O'Brien C., O'Brien L., O'Brien S., O'Reilly J., O'Rourke S., O'Sullivan M., O'Dwyer M., Ochieng L., Oderoha E., Oh K. E., Ohlberger L., Olcum M., Olkina A., Omkumar M., Omnitel B., Oncel Yakar D., Ong K., Ong Wei Lin L., Ooi R., Ooi S., Oomman A., Oon Tyjet D., Opiyo S., Oscullo Yepez J. 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J., Aguirre-Allende I., Ahari D., Ahmad H., Ahmad Rauf F., Ahmad Zartasht Khan A., Ahmed S., Ahmed Fieturi N., Ahmed Mohamed S., Ahmed-Bakhsh Z., Ahsan Javed M., Akano L., Akbar A., Akhbari M., Akhmedov P., Aksit G., Akula Y., Alagaratnam A. S., Al Majid S., Al Mukhtar O., Al Omran H., AlAsali N., Al-Azzawi M., Al-Habsi R., Al-Iraqi H., Al-Naggar H., Alameer E., Albirnawi H., Alderson D., Aldulaijan F., Alejandro Miranda Ojeda R., AlHasan A., Ali S., Ali A., Ali Khan M., Alimova Y., Aljanadi F., Aljubure R., Allopi N., Almedbal H., Almubarak M., Alqaidoom Z., Alselaim N., Alshaar M., Alshammari R., Altaf K., Altiner S., Altunpak B., Alvarez Lozada L. A., Amal Nahal E., Amer A., Amin K., Aminu U., Amisi Numbi N., Amjad T., Amoah R., An Y., Anastasopoulos N. -A., Andres Urrutia J., Angarita F., Angarita K. -L., Angel Freiria Eiras M., Antypas A., Anwar M. A., Anwar H., Apampa T. O., Apostolou K., Aquina C., Arachchige Adithi Himika Randeni R., Archila Godinez M. I., Arez O., Arezzo A. 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B., Hallesmith J., Halloran S., Hamza Sadiq M., Haney C., Hanna N., Hanna L., Hannington M., Harbjerg J., Haribaskaran D., Harran N., Harrington B., Harrison E., Hasan R., Hashmi S., Hassan M., Hassan A., Haverkamp L., Hazen S., Heer B., Heil J., Helliwell J., Henriksen N., Henshall D., Hermanson M., Hermena S., Hettiarachchi D., Hextall C., Hidalgo M., Hidayat H., Hider A., Higgins P., Hinchliffe R., Hirani D., Hirpara D., Hisham I., Hite M., Hoh S. M., Holmberg C., Holmich E., Holst F., Hossam A., Hossam Elfallal A., Howard P., Huaman E., Huang Y., Huang L., Huang D., Huber T., Hugh J., Hughes J., Huttner F., Huynh R., Hylands A., Iannuzzi J., Ielpo B., Iftikhar Talib A., Ignacio J., Ignatavicius P., Ike S., Ikwu C., Inama M., Ing A., Ingels A., Isik A., Islam N., Ives I. J., Al-Hasan A. J. M. S., Perez Rivera C. J., Jacome F., Jaffer T., Jagiella-Lodise O., Jain M., Jain K., Jakubauskas M., Jalal M., James H., Jang Y., Janssen B., Jansson H., Jariod-Ferrer U., Javanmard H., Javed S., Jayarajah U., Jayasuriya I., Je J., Jessop Z., Jia Lin Tang E., Jiang H., Jiayan Y., Jih Huei T., Jimenez-Rodriguez R., Joh D., Johnson A., Jones N., Jones C., Jordan C., Jose Nunez Ju J., Jose Pizarro M., Jose Salazar C., Joseph J., Justiniano C., Kabir T., Kadhum M., Kalfountzos C., Kalogiannaki E., Kalyanasundaram K., Kamarajah S., Kamil Quraishi M., Kanemitsu Y., Kapila A., Kapila V., Karagiannidis G., Kashif M., Kathiravelupillai S., Kathiravelupillai A., Katsogridakis E., Kaur K., Kaur Sekhon Inderjit Singh H., Kausur N., Kawka M., Keehan G., Kehlet Watt S., Kelly M., Kelly M. E., Kelvin Egbuchulem I., Kembuan G., Khajeh E., Khaled Elfaitur A., Khan M. F., Khan S., Khan M., Khan D., Khan H., Khatkar H., Khatkov E., Khaw R., Kim B., Kishore Siddiraju K., Kitua D., Kirimtay B., Kmezic S., Knight S., Koeter T., Koh A., Koh Hong Xiang F., Kojo Anyomih T., Kok A. I. N., Kokelaar R., Koliarakis I., Kolli S., Kong J., Konig D., Koshy M., Kotze P., Kourdouli A., Kowal M., Kraima A., Kramer F., Kryzauskas M., Kuchynskyi I., Kuemmerli C., Kuiper S., Kumar S., Kumar A., Kumar L., Kumar H., Kumar N., Kumar Bandyopadhyay S., Kumar Garg P., Kumar Venkatappa S., Kung J., Kural S., Kushairi A., Kuuzie E., Kvietkauskas M., Kwek I., La J., Lai L., Lakpriya S., Lam K., Lami M., Lansdorp-Vogelaar I., Lapolla P., Larsen H., Latif J., Laudari U., Laurnezi A., Lawal A., Lawday S., Lederhuber H., Lednev A., Lee R., Van Leerdam M. E., Lefevbre G., Lesmus M., Leyva Moraga F. A., Leyva Moraga E., Leyva Moraga F., Li H. L., Li A., Li Z., Licardie E., Light A., Lightner A. L., Lin A., Lincango E., Litta F., Liu H., Lofthouse B., Londono M. A., Lopes R., Lopes De Freitas R., Lopez L., Lopez A. I., Lopez-Gomez J., Lopez-Pena G., Lowe R., Lowe D., Lowey M., Loy G., Lozanovski V., Luzon J., Lynn P., MacCabe T., MacHielsen A., Mafla Herreria C. A., Maggino L., Mahawar K., Mahmood D., Mahmoud M., Mahtani K., Maitra I., Maji S., Majiet I., Mal L., Malherbe J., Malhotra K., Malkomes P., Man E., Manan Sheikh A., Manjunath S., Manzano Nunez R., Manzoor S., Maqsood R., Marchegiani G., Marchegiani F., Marin D., Marin A., Marks I., Marson E., Martensen A., Martin D., Martin Martin G., Martin-Perez B., Martinez P., Marwaha P., Mashauri C., Mashbari H., Masior L., Masri R., Masud L., Masudi S., Mateu Calabuig G., Math S., Matrachisia A., Mayol J., Mazingi D., Mazzotta A., McAlinden J., McCabe G., McColm L., McElvaney H., McGivern K., McGovern J., McGuinness E., McInerney N., McKay S., McKee C., McKenna M., McKenna N., McLean K., Mediratta S., Medkova Y., Medzhidov O., Mehraj A., Mekhael M., Mekinde O., Mellenthin C., Melucci A., Mentor K., Merchant J., Messias H., Messeha M., Meza C., Mhango P., Miladinov M., Milagros Niquen Jimenez M., Miller P., Mills E., Milton A., Minayeva O. A., MinHua Zheng Z., Mischlinger H., Mockli B., Modi R., Mohamed H. M., Mohamed M., Mohamed Abulghasm T., Mohammad S. A., Mohammed T. O., Mohammed A., Mohan H., Mohan M., Moin I., Mok V., Molina G., Moloney J., Moneim J., Monfort Mira M., Montcusi Ventura B., Montouri M., Moossdorff M., Mora-Guzman I., Moran B., Moran R. A. R., Moreno-Ordaz S., Morera A., Morgan R., Morley R., Moro-Valdezate D., Moros S., Moss J. -L., Morven A., Morton D., Moynihan A., Moyon M., Muduli N., Mugla N., Mugla W., Muller P., Mun G., Mundhada R., Munir I., Munoz F., Munoz E., Munoz A., Munoz Balderas D. C., Murgitroyd E., Murray V., Murthy S., Mushiwokufa W., Mustafa H., Mustakimov B., Mutambanengwe P., Myint P., Nadkarni S., Naess P. A., Nahar S., Naidoo P., Nam R., Nandhra S., Nanjappa N., Narasimhan V., Nardi W., Nasir M., Naughton A., Naumann D., Navarro S., Nawaaz Karimbocus M., Nazir A., Ndereya S., Ndong A., Negoi I., Nel D., Nelson D., Nepal S., Nugent T., Nepogodiev D., Neufeld J., Ng J., Ng D., Ng C. E., Ngaserin S., Ngu L., Ngwenya E., Fhearaigh R. N., Nikolousakis T. -K., Ninkovic M., Nita G., Nitschke C., Noren E., Noton T., Novikova A., Nowinka Z., Nyakunengwa T., Nyalundja A., Nzenwa I., Kristensen H. O., O'Brien C., O'Brien L., O'Brien S., O'Reilly J., O'Rourke S., O'Sullivan M., O'Dwyer M., Ochieng L., Oderoha E., Oh K. E., Ohlberger L., Olcum M., Olkina A., Omkumar M., Omnitel B., Oncel Yakar D., Ong K., Ong Wei Lin L., Ooi R., Ooi S., Oomman A., Oon Tyjet D., Opiyo S., Oscullo Yepez J. J., Osei-Kuffour N., Osunronbi T., Ottlakan A., Oussama Kacimi S., Ovaere S., Ozair A., Pachler F., Pai Oo S., Paiella S., Panaiotti L., Panda N., Pandarinath S., Pandey D., Pandrowala S., Papa Mamadou F., Paranathala M., Park J., Parmar C., Parvez A., Pasovic L., Pasquer A., Pasumarthy N., Pata F., Patel T., Patel P., Patel N., Patel M., Patron Uriburu N., Patrone R., Paul A., Pavan Kumar O. M., Pavithran A., Pedraza Ciro M., Pellino G., Peloso A., Pena Gallardo M. T., Pena Velazquez A., Perea J., Perez-Sanchez L. E., Perra T., Perrotta G., Petersson P., Petra G., Petrucciani N., Pickin C., Pino V., Pinotti E., Pinto F., Plum P., Podesta F., Pollini T., Pompeu Sa M., Ponce Leon F., Ponniah H. S., Ponte De Sousa X., Ponton J., Pontula A., Popa M., Portilla A. L., Posner F., Post S., Potolicchio A., Pouwels S., Povo A., Prasad P., Preciado S., Preece R., Proud D., Pulido Segura J. A., Puliyath N., Qui M., Quimbaya Rodriguez A. 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W., Smith H., Smith K., Smits L., Sneep-Van Kessel C., Sohrabi C., Solorzano Pineda O., Soma A., Sooriyapiragasam L., Soreide K., Sparavigna M., Spence R., Spencer N., Spiers H., Spinelli A., Sprakel J., Sravanam S., Srinivasan M., Srinivasan R., Staniszewska A., Stanworth S. J., Stasinos K., Steele R. J. C., Steinholt I., Steinruecke M., Stephen B. -J., Stijns J., Still M., Stupalkowska W., Subba S., Subbotin V. V., Sucharitkul P., Sudarsanam A., Sudhamsh Reddy D., Suhardja T., Suliman M., Sund M., Sunilkumar A., Suresh N., Sussmes S., Sutton P., Syltern J., Taha A., Takamizawa Y., Takoutsing Dongmo A. B., Tamas T., Tan L., Tan J. L., Tan K., Tan E., Tan Yong Hui A., Tanase A., Tariverdiev A., Tasnem A., Tatar C., Tay E., Tejedor P., Tesfaye G., Tetinou F., Thorpe C., Thyo A., Tlelo Amastal D., Tolani M., Tolga Saracoglu K., Tolgyes T., Tong J., Torrent Jansa L., Toscano Igartua S., Tovani Palone M. 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- Abstract
Background: Coronavirus disease 2019 (COVID-19) was declared a pandemic by the WHO on 11 March 2020 and global surgical practice was compromised. This Commission aimed to document and reflect on the changes seen in the surgical environment during the pandemic, by reviewing colleagues experiences and published evidence. Methods: In late 2020, BJS contacted colleagues across the global surgical community and asked them to describe how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had affected their practice. In addition to this, the Commission undertook a literature review on the impact of COVID-19 on surgery and perioperative care. A thematic analysis was performed to identify the issues most frequently encountered by the correspondents, as well as the solutions and ideas suggested to address them. Results: BJS received communications for this Commission from leading clinicians and academics across a variety of surgical specialties in every inhabited continent. The responses from all over the world provided insights into multiple facets of surgical practice from a governmental level to individual clinical practice and training. Conclusion: The COVID-19 pandemic has uncovered a variety of problems in healthcare systems, including negative impacts on surgical practice. Global surgical multidisciplinary teams are working collaboratively to address research questions about the future of surgery in the post-COVID-19 era. The COVID-19 pandemic is severely damaging surgical training. The establishment of a multidisciplinary ethics committee should be encouraged at all surgical oncology centres. Innovative leadership and collaboration is vital in the post-COVID-19 era.
- Published
- 2021
3. Anterior prostatectomy for the excision of bladder paraganglioma with prostatic invasion: a unique case of partial prostatectomy
- Author
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Tan, J-L, Lamb, A, Prall, O, West, C, Goad, J, Lawrentschuk, N, Tan, J-L, Lamb, A, Prall, O, West, C, Goad, J, and Lawrentschuk, N
- Published
- 2020
4. Most northern Oriental distribution of Zethus Fabricius (Hymenoptera, Vespidae, Eumeninae), with a new species from China
- Author
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Tan, J.-L., Carpenter, J.M., Achterberg, C. (Cornelis) van, Tan, J.-L., Carpenter, J.M., and Achterberg, C. (Cornelis) van
- Abstract
The distribution of Zethus Fabicius, 1804, in the Oriental and Palaearctic regions is discussed, with special reference to the northeastern Oriental species. A newly discovered species, Z. velamellatus Tan, sp. n. from China (Zhejiang), is described and illustrated. The first key to species of Zethus Fabricius from China is presented. Zethus nigerrimus Gusenleitner, 2001 is recorded for the first time from China and redescribed.
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- 2018
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5. An illustrated key to the genera of Eumeninae from China, with a checklist of species (Hymenoptera, Vespidae)
- Author
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Tan, J.-L., Carpenter, J.M., Achterberg, C. (Cornelis) van, Tan, J.-L., Carpenter, J.M., and Achterberg, C. (Cornelis) van
- Abstract
An illustrated key to the currently recognized genera of the subfamily Eumeninae (Vespidae) from China is presented together with a list of 267 species and subspecies, belonging to 51 genera. Nortozumia van der Vecht, 1937 is reported for the first time from China. Two replacement names are proposed for junior primary homonyms: Ancistrocerus rufofrustius Tan & Carpenter, nom. n. replacing Ancistrocerus rufopictus (Kostylev) and Orientalicesa confasciatus Tan & Carpenter, nom. n. repl
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- 2018
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6. Revision of the enigmatic genus Gastralysia Fischer (Hymenoptera, Braconidae, Alysiinae)
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Achterberg, C. (Cornelis) van, Tan, J.-L., Achterberg, C. (Cornelis) van, and Tan, J.-L.
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The enigmatic genus Gastralysia Fischer, 1967 (Hymenoptera: Braconidae: Alysiinae) and its type species, G. garambana Fischer, 1967, are redescribed and illustrated. The female is described for the first time. The position of the genus is discussed and the genus is placed in a new subtribus, Gastralysiina subtrib. n. The genus is reported new for Ivory Coast and Tanzania.
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- 2018
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7. Comparison of perioperative, renal and oncologic outcomes in robotic-assisted versus open partial nephrectomy
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Tan, J-L, Frydenberg, M, Grummet, J, Hanegbi, U, Snow, R, Mann, S, Begashaw, K, Moon, D, Tan, J-L, Frydenberg, M, Grummet, J, Hanegbi, U, Snow, R, Mann, S, Begashaw, K, and Moon, D
- Abstract
BACKGROUND: To compare perioperative, renal and oncological outcomes after robotic-assisted partial nephrectomy (RAPN) versus open partial nephrectomy (OPN) for the treatment of renal tumours. METHODS: All partial nephrectomies performed at a Metropolitan Urology Centre between 2010 and 2016 were analysed. Baseline data was collected for patient demographics, tumour characteristics (tumour size, laterality and polarity, RENAL scores), and perioperative variables (e.g. warm ischaemic time, operation time, estimated blood loss (EBL), length of stay). Tumour characteristics included malignancy, clinical stage, Fuhrman nuclear grade and surgical margin status. Day-1 post-operative serum creatinine, estimated glomerular filtration rate (eGFR) and 6-month eGFR stage were used for assessing renal function. RESULTS: Two hundred patients underwent partial nephrectomy between 2010 and 2016 (n = 200; 55 OPN versus 145 RAPN). Baseline data was similar between groups, except for lower age (P = 0.0001) and higher RENAL scores (P = 0.001) in the RAPN group. RAPN demonstrated significantly lower complication rates (P = 0.015), lesser EBL (P = <0.0001), shorter hospital stays (P = <0.001) and reduced positive tumour resection margins (P = 0.039). There was no significant difference in mean operation time between RAPN and OPN (137.2 (±48.0) OPN versus 146.07 (±35.91) RAPN; P = 0.16). No statistical difference was shown for post-operative eGFR stage between groups at Day-1 and 6-month post-surgery (P = 0.15 and P = 0.861, respectively). CONCLUSION: We present the largest reported Australian series on partial nephrectomy, confirming that a robotic-assisted approach is equivalent to OPN, with reduced complications, EBL, length of hospital stays and fewer positive margins, even when resecting more complex tumours.
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- 2018
8. Most northern Oriental distribution of Zethus Fabricius (Hymenoptera, Vespidae, Eumeninae), with a new species from China
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Tan, J.-L., Carpenter, J.M., Achterberg, C. (Cornelis) van, Tan, J.-L., Carpenter, J.M., and Achterberg, C. (Cornelis) van
- Abstract
The distribution of Zethus Fabicius, 1804, in the Oriental and Palaearctic regions is discussed, with special reference to the northeastern Oriental species. A newly discovered species, Z. velamellatus Tan, sp. n. from China (Zhejiang), is described and illustrated. The first key to species of Zethus Fabricius from China is presented. Zethus nigerrimus Gusenleitner, 2001 is recorded for the first time from China and redescribed.
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- 2018
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9. An illustrated key to the genera of Eumeninae from China, with a checklist of species (Hymenoptera, Vespidae)
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Tan, J.-L., Carpenter, J.M., Achterberg, C. (Cornelis) van, Tan, J.-L., Carpenter, J.M., and Achterberg, C. (Cornelis) van
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An illustrated key to the currently recognized genera of the subfamily Eumeninae (Vespidae) from China is presented together with a list of 267 species and subspecies, belonging to 51 genera. Nortozumia van der Vecht, 1937 is reported for the first time from China. Two replacement names are proposed for junior primary homonyms: Ancistrocerus rufofrustius Tan & Carpenter, nom. n. replacing Ancistrocerus rufopictus (Kostylev) and Orientalicesa confasciatus Tan & Carpenter, nom. n. replacing Orientalicesa unifasciatus (von Schulthess, 1934).
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- 2018
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10. Revision of the enigmatic genus Gastralysia Fischer (Hymenoptera, Braconidae, Alysiinae)
- Author
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Achterberg, C. (Cornelis) van, Tan, J.-L., Achterberg, C. (Cornelis) van, and Tan, J.-L.
- Abstract
The enigmatic genus Gastralysia Fischer, 1967 (Hymenoptera: Braconidae: Alysiinae) and its type species, G. garambana Fischer, 1967, are redescribed and illustrated. The female is described for the first time. The position of the genus is discussed and the genus is placed in a new subtribus, Gastralysiina subtrib. n. The genus is reported new for Ivory Coast and Tanzania.
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- 2018
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11. New species of Trigonalyidae (Hymenoptera) from NW China
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Tan, J.-L., Achterberg, C. (Cornelis) van, Tan, Q.-Q., Zhao, L.-P., Tan, J.-L., Achterberg, C. (Cornelis) van, Tan, Q.-Q., and Zhao, L.-P.
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Four new species of Trigonalyidae are described and illustrated from Qinling Mts (Shaanxi, NW China): Bareogonalos xibeidai Tan & van Achterberg, sp. n., Jezonogonalos mandibularis sp. n., J. shaanxiensis sp. n., and Taeniogonalos paraclypeata sp. n. Orthogonalys hirasana Teranishi, 1929, is re-instated and reported from China. The female of Taeniogonalos alticola (Tsuneki, 1991) is described for the first time. In total, 18 species are known from Shaanxi province, 20 species for NW China, and eight described species are newly recorded for Shaanxi: Jezonogonalos luteata Chen et al., 2014, Orthogonalys hirasana Teranishi, 1929, O. elongata Teranishi, 1929, Pseudogonalos hahnii (Spinola, 1840), Taeniogonalos alticola (Tsuneki,1991), T. formosana (
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- 2017
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12. New species of Trigonalyidae (Hymenoptera) from NW China
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Tan, J.-L., Achterberg, C. (Cornelis) van, Tan, Q.-Q., Zhao, L.-P., Tan, J.-L., Achterberg, C. (Cornelis) van, Tan, Q.-Q., and Zhao, L.-P.
- Abstract
Four new species of Trigonalyidae are described and illustrated from Qinling Mts (Shaanxi, NW China): Bareogonalos xibeidai Tan & van Achterberg, sp. n., Jezonogonalos mandibularis sp. n., J. shaanxiensis sp. n., and Taeniogonalos paraclypeata sp. n. Orthogonalys hirasana Teranishi, 1929, is re-instated and reported from China. The female of Taeniogonalos alticola (Tsuneki, 1991) is described for the first time. In total, 18 species are known from Shaanxi province, 20 species for NW China, and eight described species are newly recorded for Shaanxi: Jezonogonalos luteata Chen et al., 2014, Orthogonalys hirasana Teranishi, 1929, O. elongata Teranishi, 1929, Pseudogonalos hahnii (Spinola, 1840), Taeniogonalos alticola (Tsuneki,1991), T. formosana (Bischoff, 1913), T. taihorina (Bischoff, 1914), and Teranishia glabrata Chen et al., 2014. Poecilogonalos maga Teranishi, 1929, syn. n. and Taiwanogonalos claripennis Tsuneki, 1991, syn. n. are new synonyms of Taeniogonalos taihorina (Bischoff, 1914) and Taiwanogonalos alishana Tsuneki, 1991, syn. n. of Taeniogonalos alticola (Tsuneki, 1991). Revised keys to species of the genera Bareogonalos, Jezonogonalos, and Orthogonalys are included.
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- 2017
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13. Review of the East Palaearctic and North Oriental Psyttalia Walker, with the description of three new species (Hymenoptera, Braconidae, Opiinae)
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Wu, Q., Achterberg, C. (Cornelis) van, Tan, J.-L., Chen, X.-X. ((the one)), Wu, Q., Achterberg, C. (Cornelis) van, Tan, J.-L., and Chen, X.-X. ((the one))
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The East Palaearctic and North Oriental species of the genus Psyttalia Walker (Hymenoptera, Braconidae, Opiinae) are reviewed. Three new species are described and illustrated: P. latinervis Wu & van Achterberg, sp. n. and P. majocellata Wu & van Achterberg, sp. n. from China, and P. spectabilis van Achterberg, sp. n. from Japan. Coeloreuteus formosanus Watanabe, 1934, Opius (Lissosema) proclivis Papp, 1981, O. (Psyttalia) subcyclogaster Tobias, 1998, O. (P.) darasunicus Tobias, 1998, O. (P.) cyclogastroides Tobias, 1998, Psyttalia extensa Weng & Chen, 2001, and Rhogadopsis longicaudifera Li & van Achterberg, 2013, are new synonyms of Psyttalia cyclogaster (Thomson, 1895); Opius (Psyttalia) ophthalmicus Tobias, 1977, and O. (P.) brevitemporalis Tobias, 1998, of Psyttalia carinata (Thomson, 1895) and both O. (P.) vacuus Tobias, 1998, and O. (Lissosema) longurius Chen & Weng, 1995, of Rhogadopsis mediocarinata (Fischer, 1963). Phaedrotoma daghestanicum (Telenga, 1950), Rhogadopsis mediocarinata (Fischer, 1963) and R. mystica (Fischer, 1963) are new combinations. New records are Psyttalia carinata (Thomson, 1895) from The Netherlands and Norway, and P. cyclogaster (Thomson, 1895) from Japan. A lectotype is designated for Psyttalia carinata (Thomson, 1895) and P. cyclogaster (Thomson, 1895). A key to the East Palaearctic and North Oriental species of the genus Psyttalia Walker is included.
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- 2016
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14. Four new species of Rhogadopsis Brèthes from NW China (Hymenoptera, Braconidae, Opiinae)
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Chen, M., Achterberg, C. (Cornelis) van, Tan, J.-L., Tan, Q.-q., Chen, X.-X. ((the one)), Chen, M., Achterberg, C. (Cornelis) van, Tan, J.-L., Tan, Q.-q., and Chen, X.-X. ((the one))
- Abstract
Four new species of the genus Rhogadopsis Brèthes, 1913 (Hymenoptera, Braconidae, Opiinae) are reported from Shaanxi province (NW China). The new species (R. aciculifera sp. n., R. cracentata sp. n., R. longivena sp. n., and R. moniliata sp. n.) and two newly recorded species for Shaanxi and Ningxia provinces (R. mediocarinata (Fischer, 1963) and R. pratellae (Weng & Chen, 2005), respectively) are keyed and fully illustrated. Rhogadopsis mediocarinata (Fischer, 1963) is a new combination.
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- 2016
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15. Four new species of Gasteruption Latreille from NW China, with an illustrated key to the species from Palaearctic China (Hymenoptera, Gasteruptiidae)
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Tan, J.-L., Achterberg, C. (Cornelis) van, Tan, Q.-Q., Chen, X.-X. ((the one)), Tan, J.-L., Achterberg, C. (Cornelis) van, Tan, Q.-Q., and Chen, X.-X. ((the one))
- Abstract
Four new species of the genus Gasteruption Latreille, 1796 (Hymenoptera: Evanioidea: Gasteruptiidae: Gasteruptiinae) are reported from NW China: three from Shaanxi province and one from Ningxia province. The new species (G. bicoloratum Tan & van Achterberg, sp. n., G. huangshii Tan & van Achterberg, sp. n., G. pannuceum Tan & van Achterberg, sp. n., and G. shengi Tan & van Achterberg, sp. n.) and three newly recorded species (G. sinepunctatum Zhao, van Achterberg & Xu, 2012, G. boreale (Thomson, 1883) and G. oshimense Watanabe, 1924) are keyed and fully illustrated. In total, seven species are known from Shaanxi province, which is approximately half of the expected number. The East Palaearctic specimens provisionally identified as G. tournieri Schletterer, 1885, by Zhao et al. (2012) are included under G. oshimense Watanabe, 1924.
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- 2016
- Full Text
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16. Review of the East Palaearctic and North Oriental Psyttalia Walker, with the description of three new species (Hymenoptera, Braconidae, Opiinae)
- Author
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Wu, Q., Achterberg, C. (Cornelis) van, Tan, J.-L., Chen, X.-X. ((the one)), Wu, Q., Achterberg, C. (Cornelis) van, Tan, J.-L., and Chen, X.-X. ((the one))
- Abstract
The East Palaearctic and North Oriental species of the genus Psyttalia Walker (Hymenoptera, Braconidae, Opiinae) are reviewed. Three new species are described and illustrated: P. latinervis Wu & van Achterberg, sp. n. and P. majocellata Wu & van Achterberg, sp. n. from China, and P. spectabilis van Achterberg, sp. n. from Japan. Coeloreuteus formosanus Watanabe, 1934, Opius (Lissosema) proclivis Papp, 1981, O. (Psyttalia) subcyclogaster Tobias, 1998, O. (P.) darasunicus Tobias, 1998, O. (P.) cyclogastroides Tobias, 1998, Psyttalia extensa Weng & Chen, 2001, and Rhogadopsis longicaudifera Li & van Achterberg, 2013, are new synonyms of Psyttalia cyclogaster (Thomson, 1895); Opius (Psyttalia) ophthalmicus Tobias, 1977, and O. (P.) brevitemporalis Tobias, 1998, of Psyttalia carinata (Thomson, 1895) and both O. (P.) vacuus Tobias, 1998, and O. (Lissosema) longurius Chen & Weng, 1995, of Rhogadopsis mediocarinata (Fischer, 1963). Phaedrotoma daghestanicum (Telenga, 1950), Rhogadopsis mediocarinata (Fischer, 1963) and R. mystica (Fischer, 1963) are new combinations. New records are Psyttalia carinata (Thomson, 1895) from The Netherlands and Norway, and P. cyclogaster (Thomson, 1895) from Japan. A lectotype is designated for Psyttalia carinata (Thomson, 1895) and P. cyclogaster (Thomson, 1895). A key to the East Palaearctic and North Oriental species of the genus Psyttalia Walker is included.
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- 2016
- Full Text
- View/download PDF
17. Four new species of Rhogadopsis Brèthes from NW China (Hymenoptera, Braconidae, Opiinae)
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Chen, M., Achterberg, C. (Cornelis) van, Tan, J.-L., Tan, Q.-q., Chen, X.-X. ((the one)), Chen, M., Achterberg, C. (Cornelis) van, Tan, J.-L., Tan, Q.-q., and Chen, X.-X. ((the one))
- Abstract
Four new species of the genus Rhogadopsis Brèthes, 1913 (Hymenoptera, Braconidae, Opiinae) are reported from Shaanxi province (NW China). The new species (R. aciculifera sp. n., R. cracentata sp. n., R. longivena sp. n., and R. moniliata sp. n.) and two newly recorded species for Shaanxi and Ningxia provinces (R. mediocarinata (Fischer, 1963) and R. pratellae (Weng & Chen, 2005), respectively) are keyed and fully illustrated. Rhogadopsis mediocarinata (Fischer, 1963) is a new combination.
- Published
- 2016
- Full Text
- View/download PDF
18. Four new species of Gasteruption Latreille from NW China, with an illustrated key to the species from Palaearctic China (Hymenoptera, Gasteruptiidae)
- Author
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Tan, J.-L., Achterberg, C. (Cornelis) van, Tan, Q.-Q., Chen, X.-X. ((the one)), Tan, J.-L., Achterberg, C. (Cornelis) van, Tan, Q.-Q., and Chen, X.-X. ((the one))
- Abstract
Four new species of the genus Gasteruption Latreille, 1796 (Hymenoptera: Evanioidea: Gasteruptiidae: Gasteruptiinae) are reported from NW China: three from Shaanxi province and one from Ningxia province. The new species (G. bicoloratum Tan & van Achterberg, sp. n., G. huangshii Tan & van Achterberg, sp. n., G. pannuceum Tan & van Achterberg, sp. n., and G. shengi Tan & van Achterberg, sp. n.) and three newly recorded species (G. sinepunctatum Zhao, van Achterberg & Xu, 2012, G. boreale (Thomson, 1883) and G. oshimense Watanabe, 1924) are keyed and fully illustrated. In total, seven species are known from Shaanxi province, which is approximately half of the expected number. The East Palaearctic specimens provisionally identified as G. tournieri Schletterer, 1885, by Zhao et al. (2012) are included under G. oshimense Watanabe, 1924.
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- 2016
- Full Text
- View/download PDF
19. A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation
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Massachusetts Institute of Technology. Computational and Systems Biology Program, Massachusetts Institute of Technology. Department of Biology, Whitehead Institute for Biomedical Research, Young, Richard A, Fan, Zi Peng, Kaufman, C. K., Mosimann, C., Yang, S., Thomas, A. J., Ablain, J., Tan, J. L., Fogley, R. D., van Rooijen, E., Hagedorn, E. J., Ciarlo, C., White, R. M., Matos, D. A., Puller, A.-C., Santoriello, C., Liao, E. C., Zon, L. I., Young, Richard A., Massachusetts Institute of Technology. Computational and Systems Biology Program, Massachusetts Institute of Technology. Department of Biology, Whitehead Institute for Biomedical Research, Young, Richard A, Fan, Zi Peng, Kaufman, C. K., Mosimann, C., Yang, S., Thomas, A. J., Ablain, J., Tan, J. L., Fogley, R. D., van Rooijen, E., Hagedorn, E. J., Ciarlo, C., White, R. M., Matos, D. A., Puller, A.-C., Santoriello, C., Liao, E. C., Zon, L. I., and Young, Richard A.
- Abstract
The “cancerized field” concept posits that cancer-prone cells in a given tissue share an oncogenic mutation, but only discreet clones within the field initiate tumors. Most benign nevi carry oncogenic BRAF[superscript V600E] mutations but rarely become melanoma. The zebrafish crestin gene is expressed embryonically in neural crest progenitors (NCPs) and specifically reexpressed in melanoma. Live imaging of transgenic zebrafish crestin reporters shows that within a cancerized field (BRAF[superscript V600E]-mutant; p53-deficient), a single melanocyte reactivates the NCP state, revealing a fate change at melanoma initiation in this model. NCP transcription factors, including sox10, regulate crestin expression. Forced sox10 overexpression in melanocytes accelerated melanoma formation, which is consistent with activation of NCP genes and super-enhancers leading to melanoma. Our work highlights NCP state reemergence as a key event in melanoma initiation.
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- 2016
20. Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder
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Grubman, A, Lidgerwood, GE, Duncan, C, Bica, L, Tan, J-L, Parker, SJ, Caragounis, A, Meyerowitz, J, Volitakis, I, Moujalled, D, Liddell, JR, Hickey, JL, Horne, M, Longmuir, S, Koistinaho, J, Donnelly, PS, Crouch, PJ, Tammen, I, White, AR, Kanninen, KM, Grubman, A, Lidgerwood, GE, Duncan, C, Bica, L, Tan, J-L, Parker, SJ, Caragounis, A, Meyerowitz, J, Volitakis, I, Moujalled, D, Liddell, JR, Hickey, JL, Horne, M, Longmuir, S, Koistinaho, J, Donnelly, PS, Crouch, PJ, Tammen, I, White, AR, and Kanninen, KM
- Abstract
BACKGROUND: Aberrant biometal metabolism is a key feature of neurodegenerative disorders including Alzheimer's and Parkinson's diseases. Metal modulating compounds are promising therapeutics for neurodegeneration, but their mechanism of action remains poorly understood. Neuronal ceroid lipofuscinoses (NCLs), caused by mutations in CLN genes, are fatal childhood neurodegenerative lysosomal storage diseases without a cure. We previously showed biometal accumulation in ovine and murine models of the CLN6 variant NCL, but the mechanism is unknown. This study extended the concept that alteration of biometal functions is involved in pathology in these disorders, and investigated molecular mechanisms underlying impaired biometal trafficking in CLN6 disease. RESULTS: We observed significant region-specific biometal accumulation and deregulation of metal trafficking pathways prior to disease onset in CLN6 affected sheep. Substantial progressive loss of the ER/Golgi-resident Zn transporter, Zip7, which colocalized with the disease-associated protein, CLN6, may contribute to the subcellular deregulation of biometal homeostasis in NCLs. Importantly, the metal-complex, ZnII(atsm), induced Zip7 upregulation, promoted Zn redistribution and restored Zn-dependent functions in primary mouse Cln6 deficient neurons and astrocytes. CONCLUSIONS: This study demonstrates the central role of the metal transporter, Zip7, in the aberrant biometal metabolism of CLN6 variants of NCL and further highlights the key contribution of deregulated biometal trafficking to the pathology of neurodegenerative diseases. Importantly, our results suggest that ZnII(atsm) may be a candidate for therapeutic trials for NCLs.
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- 2014
21. Increased Zinc and Manganese in Parallel with Neurodegeneration, Synaptic Protein Changes and Activation of Akt/GSK3 Signaling in Ovine CLN6 Neuronal Ceroid Lipofuscinosis
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Kahle, PJ, Kanninen, KM, Grubman, A, Meyerowitz, J, Duncan, C, Tan, J-L, Parker, SJ, Crouch, PJ, Paterson, BM, Hickey, JL, Donnelly, PS, Volitakis, I, Tammen, I, Palmer, DN, White, AR, Kahle, PJ, Kanninen, KM, Grubman, A, Meyerowitz, J, Duncan, C, Tan, J-L, Parker, SJ, Crouch, PJ, Paterson, BM, Hickey, JL, Donnelly, PS, Volitakis, I, Tammen, I, Palmer, DN, and White, AR
- Abstract
Mutations in the CLN6 gene cause a variant late infantile form of neuronal ceroid lipofuscinosis (NCL; Batten disease). CLN6 loss leads to disease clinically characterized by vision impairment, motor and cognitive dysfunction, and seizures. Accumulating evidence suggests that alterations in metal homeostasis and cellular signaling pathways are implicated in several neurodegenerative and developmental disorders, yet little is known about their role in the NCLs. To explore the disease mechanisms of CLN6 NCL, metal concentrations and expression of proteins implicated in cellular signaling pathways were assessed in brain tissue from South Hampshire and Merino CLN6 sheep. Analyses revealed increased zinc and manganese concentrations in affected sheep brain in those regions where neuroinflammation and neurodegeneration first occur. Synaptic proteins, the metal-binding protein metallothionein, and the Akt/GSK3 and ERK/MAPK cellular signaling pathways were also altered. These results demonstrate that altered metal concentrations, synaptic protein changes, and aberrant modulation of cellular signaling pathways are characteristic features in the CLN6 ovine form of NCL.
- Published
- 2013
22. Diacetylbis(N(4)-methylthiosemicarbazonato) Copper(II) (Cu-II(atsm)) Protects against Peroxynitrite-induced Nitrosative Damage and Prolongs Survival in Amyotrophic Lateral Sclerosis Mouse Model
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Soon, CPW, Donnelly, PS, Turner, BJ, Hung, LW, Crouch, PJ, Sherratt, NA, Tan, J-L, Lim, NK-H, Lam, L, Bica, L, Lim, S, Hickey, JL, Morizzi, J, Powell, A, Finkelstein, DI, Culvenor, JG, Masters, CL, Duce, J, White, AR, Barnham, KJ, Li, Q-X, Soon, CPW, Donnelly, PS, Turner, BJ, Hung, LW, Crouch, PJ, Sherratt, NA, Tan, J-L, Lim, NK-H, Lam, L, Bica, L, Lim, S, Hickey, JL, Morizzi, J, Powell, A, Finkelstein, DI, Culvenor, JG, Masters, CL, Duce, J, White, AR, Barnham, KJ, and Li, Q-X
- Abstract
Amyotrophic lateral sclerosis (ALS) is a progressive paralyzing disease characterized by tissue oxidative damage and motor neuron degeneration. This study investigated the in vivo effect of diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)), which is an orally bioavailable, blood-brain barrier-permeable complex. In vitro the compound inhibits the action of peroxynitrite on Cu,Zn-superoxide dismutase (SOD1) and subsequent nitration of cellular proteins. Oral treatment of transgenic SOD1G93A mice with CuII(atsm) at presymptomatic and symptomatic ages was performed. The mice were examined for improvement in lifespan and motor function, as well as histological and biochemical changes to key disease markers. Systemic treatment of SOD1G93A mice significantly delayed onset of paralysis and prolonged lifespan, even when administered to symptomatic animals. Consistent with the properties of this compound, treated mice had reduced protein nitration and carbonylation, as well as increased antioxidant activity in spinal cord. Treatment also significantly preserved motor neurons and attenuated astrocyte and microglial activation in mice. Furthermore, CuII(atsm) prevented the accumulation of abnormally phosphorylated and fragmented TAR DNA-binding protein-43 (TDP-43) in spinal cord, a protein pivotal to the development of ALS. CuII(atsm) therefore represents a potential new class of neuroprotective agents targeting multiple major disease pathways of motor neurons with therapeutic potential for ALS.
- Published
- 2011
23. Effects of laser ablation on cemented tungsten carbide surface quality
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Tan, J. L., Butler, D. L., Sim, L. M., Jarfors, A. E. W., Tan, J. L., Butler, D. L., Sim, L. M., and Jarfors, A. E. W.
- Abstract
Although laser micromachining has been touted as being the most promising way to fabricate micro tools, there has been no proper evaluation of the effects of laser ablation on bulk material properties. The current work demonstrates the effects of laser ablation on the properties of a cemented tungsten carbide surface. Of particular interest is the resultant increase in compressive residual stresses in the ablated surface. From this study it is seen that there are no adverse effects from laser ablation of cemented tungsten carbide that would preclude its use for the fabrication of micro-tools but a finishing process may not be avoidable. © 2010 Springer-Verlag.
- Published
- 2010
- Full Text
- View/download PDF
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