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Recently, lattice formulations of Abelian chiral gauge theory in two dimensions have been devised on the basis of the Abelian bosonization. A salient feature of these 2D lattice formulations is that the gauge invariance is \emph{exactly\/} preserved for anomaly-free theories and thus is completely free from the question of the gauge mode decoupling. In the present paper, we propose a yet another lattice formulation sharing this desired property. A particularly unique point in our formulation is that the vertex operator of the dual scalar field, which carries the vector charge of the fermion and the ``magnetic charge'' in the bosonization, is represented by a ``hole'' excised from the lattice; this is the excision method formulated recently by Abe et al. in a somewhat different context., Comment: 16 pages, 3 figures, the final version to appear in PTEP

In $U(1)$ lattice gauge theory with compact $U(1)$ variables, we construct the symmetry operator, i.e.\ the topological defect, for the axial $U(1)$ noninvertible symmetry. This requires a lattice formulation of chiral gauge theory with an anomalous matter content and we employ the lattice formulation on the basis of the Ginsparg--Wilson relation. The invariance of the symmetry operator under the gauge transformation of the gauge field on the defect is realized, imitating the prescription by Karasik in continuum theory, by integrating the lattice Chern--Simons term on the defect over \emph{smooth\/} lattice gauge transformations. The projection operator for allowed magnetic fluxes on the defect then emerges with lattice regularization. The resulting symmetry operator is manifestly invariant under lattice gauge transformations. In an appendix, we give another way of constructing the symmetry operator on the basis of a 3D $\mathbb{Z}_N$ topological quantum field theory, the level-$N$ BF theory on the lattice., Comment: 47 pages, 5 figures, the final version to appear in PTEP

Achaete-scute family bHLH transcription factor 1 (ASCL1) is a master transcription factor involved in neuroendocrine differentiation. ASCL1 is expressed in approximately 10% of lung adenocarcinomas (LUAD) and exerts tumor-promoting effects. Here, we explored miRNA profiles in ASCL1-positive LUADs and identified several miRNAs closely associated with ASCL1 expression, including miR-375, miR-95-3p/miR-95-5p, miR-124-3p, and members of the miR-17 similar to 92 family. Similar to small cell lung cancer, Yes1 associated transcriptional regulator (YAP1), a representative miR-375 target gene, was suppressed in ASCL1-positive LUADs. ASCL1 knockdown followed by miRNA profiling in a cell culture model further revealed that ASCL1 positively regulates miR-124-3p and members of the miR-17 similar to 92 family. Integrative transcriptomic analyses identified ZFP36 ring finger protein like 1 (ZFP36L1) as a target gene of miR-124-3p, and IHC studies demonstrated that ASCL1-positive LUADs are associated with low ZFP36L1 protein levels. Cell culture studies showed that ectopic ZFP36L1 expression inhibits cell proliferation, survival, and cell-cycle progression. Moreover, ZFP36L1 negatively regulated several genes including E2F transcription factor 1 (E2F1) and snail family transcriptional repressor 1 (SNAI1). In conclusion, our study revealed that suppression of ZFP36L1 via ASCL1-regulated miR-124-3p could modulate gene expression, providing evidence that ASCL1-mediated regulation of miRNAs shapes molecular features of ASCL1-positive LUADs.Implications: Our study revealed unique miRNA profiles of ASCL1-positive LUADs and identified ASCL1-regulated miRNAs with functional relevance.

Employing the modified Villain lattice formulation of the axion QED, we present an alternative and much simpler derivation of the conclusion of~Ref.~\cite{Honda:2024sdz} that the sweep of the axial $U(1)$ non-invertible symmetry operator over the (non-genuine) gauge invariant 't~Hooft line operator with an integer magnetic charge does not leave any effect. The point is that such a 't~Hooft line can be represented by a boundary of a (non-topological) defect that is invariant under the axial transformation on the axion field., Comment: 12 pages, 1 figure

Employing the modified Villain lattice formulation of the axion QED, we present an alternative and much simpler derivation of the conclusion of~Ref.~\cite{Honda:2024sdz} that the sweep of the axial $U(1)$ non-invertible symmetry operator over the (non-genuine) gauge invariant 't~Hooft line operator with an integer magnetic charge does not leave any effect. The point is that such a 't~Hooft line can be represented by a boundary of a (non-topological) defect that is invariant under the axial transformation on the axion field., Comment: 12 pages, 1 figure

We study how the symmetry operator of the axial $U(1)$ non-invertible symmetry acts on the 't~Hooft line operator in the $U(1)$ gauge theory by employing the modified Villain-type lattice formulation. We model the axial anomaly by a compact scalar boson, the ``QED axion''. For the gauge invariance, the simple 't~Hooft line operator, which is defined by a line integral of the dual $U(1)$ gauge potential, must be ``dressed'' by the scalar and $U(1)$ gauge fields. A careful consideration on the basis of the anomalous Ward--Takahashi identity containing the 't~Hooft operator with the dressing factor and a precise definition of the symmetry operator on the lattice shows that the symmetry operator leaves no effect when it sweeps out a 't~Hooft loop operator. This result appears inequivalent with the phenomenon concluded in the continuum theory. In an appendix, we demonstrate that the half-space gauging of the magnetic $\mathbb{Z}_N$ 1-form symmetry, when formulated in an appropriate lattice framework, leads to the same conclusion as above. A similar result is obtained for the axion string operator., Comment: 21 pages, 1 figure. The final version to appear in PTEP

In conventional ionization chambers (ICs) using P-10 (Ar+CH4) gas, as the atomic number (Z) of the ion beams increases in the energy region of 200-300 MeV/u, the Z resolution deteriorates rapidly when Z>70. This degradation is attributed to substantial energy loss straggling caused by charge state fluctuation when the beams traverse a gas medium. The energy loss straggling intensifies when the beams cannot attain charge state equilibrium in the IC gas. In this study, a xenon-based gas (Xe+CH4), presenting a larger charge state changing cross section, was employed in the IC to reach charge state equilibrium. The responses of ICs with P-10 and the xenon-based gases were examined using 238U beams and cocktail radioactive isotope (RI) beams with Z=40-90 at the RI Beam Factory (RIBF). For 238U beams at 165-344 MeV/u, the P-10 gas IC yielded an energy resolution of 1.9-3.0% in full width at half maximum (FWHM), which proved inadequate for Z identification in the uranium region. In contrast, the xenon-based gas IC demonstrated a satisfactory energy resolution of 1.4-1.6%. When using cocktail RI beams, a Z resolution of 1.28 and 0.74 was achieved by the P-10 and the xenon-based gas ICs, respectively, for beams with Z=84-88 at 200 MeV/u. The contrast in Z resolutions between the P-10 and the xenon-based gas ICs was effectively elucidated by the energy loss straggling model, incorporating collisional straggling and straggling due to charge state changes in the IC gases. The xenon-based gas IC, with more than 3sigma Z separation across a broad Z range (Z=40-90), emerged as a practical solution for Z identification of heavy ion beams., Comment: 21 pages, 12 figures, 1 table

In $U(1)$ lattice gauge theory with compact $U(1)$ variables, we construct the symmetry operator, i.e.\ the topological defect, for the axial $U(1)$ noninvertible symmetry. This requires a lattice formulation of chiral gauge theory with an anomalous matter content and we employ the lattice formulation on the basis of the Ginsparg--Wilson relation. The invariance of the symmetry operator under the gauge transformation of the gauge field on the defect is realized, imitating the prescription by Karasik in continuum theory, by integrating the lattice Chern--Simons term on the defect over \emph{smooth\/} lattice gauge transformations. The projection operator for allowed magnetic fluxes on the defect then emerges with lattice regularization. The resulting symmetry operator is manifestly invariant under lattice gauge transformations. In an appendix, we give another way of constructing the symmetry operator on the basis of a 3D $\mathbb{Z}_N$ topological quantum field theory, the level-$N$ BF theory on the lattice., Comment: 47 pages, 5 figures, the final version to appear in PTEP

Recently, lattice formulations of Abelian chiral gauge theory in two dimensions have been devised on the basis of the Abelian bosonization. A salient feature of these two-dimensional lattice formulations is that the gauge invariance is \emph{exactly\/} preserved for anomaly-free theories and thus is completely free from the question of the gauge mode decoupling. In the present paper, we propose a yet another lattice formulation sharing this desired property. A particularly unique point in our formulation is that the vertex operator of the dual scalar field, which carries the vector charge of the fermion and the ``magnetic charge'' in the bosonization, is represented by a ``hole'' excised from the lattice; this is the excision method formulated recently by Abe et al. in a somewhat different context., Comment: 16 pages, 3 figures

We study how the symmetry operator of the axial $U(1)$ non-invertible symmetry acts on the 't~Hooft line operator in the $U(1)$ gauge theory by employing the modified Villain-type lattice formulation. We model the axial anomaly by a compact scalar boson, the ``QED axion''. For the gauge invariance, the simple 't~Hooft line operator, which is defined by a line integral of the dual $U(1)$ gauge potential, must be ``dressed'' by the scalar and $U(1)$ gauge fields. A careful consideration on the basis of the anomalous Ward--Takahashi identity containing the 't~Hooft operator with the dressing factor and a precise definition of the symmetry operator on the lattice shows that the symmetry operator leaves no effect when it sweeps out a 't~Hooft loop operator. This result appears inequivalent with the phenomenon concluded in the continuum theory. In an appendix, we demonstrate that the half-space gauging of the magnetic $\mathbb{Z}_N$ 1-form symmetry, when formulated in an appropriate lattice framework, leads to the same conclusion as above. A similar result is obtained for the axion string operator., Comment: 21 pages, 1 figure. The final version to appear in PTEP

The gradient flow exact renormalization group (GFERG) is an idea that incorporates gauge invariant gradient flows into the formalism of the exact renormalization group (ERG). GFERG introduces a Wilson action with a cutoff while keeping vector gauge invariance manifestly. The details of the formalism are still to be worked out. In this paper, we apply GFERG to construct the Wilson action of massless Dirac fermions under the background chiral gauge fields. By formulating the chiral anomaly as a ``composite operator,'' we make the scale invariance of the anomaly manifest. We argue that the same result extends to QCD., Comment: 25 pages

We extend the definition of L\"uscher's lattice topological charge to the case of $4$d $SU(N)$ gauge fields coupled with $\mathbb{Z}_N$ $2$-form gauge fields. This result is achieved while maintaining the locality, the $SU(N)$ gauge invariance, and $\mathbb{Z}_N$ $1$-form gauge invariance, and we find that the manifest $1$-form gauge invariance plays the central role in our construction. This result gives the lattice regularized derivation of the mixed 't Hooft anomaly in pure $SU(N)$ Yang-Mills theory between its $\mathbb{Z}_N$ $1$-form symmetry and the $\theta$ periodicity., Comment: 20 pages, 3 figures; (v2) minor improvements, refs updated

BACKGROUND: High bleeding risk (HBR) and complex percutaneous coronary intervention (PCI) are major determinants for dual antiplatelet therapy (DAPT) duration. OBJECTIVES: The aim of this study was to evaluate the effects of HBR and complex PCI on short vs standard DAPT. METHODS: Subgroup analyses were conducted on the basis of Academic Research Consortium-defined HBR and complex PCI in the STOPDAPT-2 (Short and Optimal Duration of Dual Antiplatelet Therapy After Verulam's-Eluting Cobalt-Chromium Stent-2) Total Cohort, which randomly compared clopidogrel monotherapy after 1-month DAPT with 12-month DAPT with aspirin and clopidogrel after PCI. The primary endpoint was the composite of cardiovascular (cardiovascular death, myocardial infarction, definite stent thrombosis, or stroke) or bleeding (Thrombolysis In Myocardial Infarction [TIMI] major or minor) endpoints at 1 year. RESULTS: Regardless of HBR (n = 1, 893 [31.6%]) and complex PCI (n = 999 [16.7%]), the risk of 1-month DAPT relative to 12-month DAPT was not significant for the primary endpoint (HBR, 5.01% vs 5.14%; non-HBR, 1.90% vs 2.02%; P interaction = 0.95) (complex PCI, 3.15% vs 4.07%; noncomplex PCI, 2.78% vs 2.82%; P interaction = 0.48) and for the cardiovascular endpoint (HBR, 4.35% vs 3.52%; and non-HBR, 1.56% vs 1.22%; P interaction = 0.90) (complex PCI, 2.53% vs 2.52%; noncomplex PCI, 2.38% vs 1.86%; P interaction = 0.53), while it was lower for the bleeding endpoint (HBR, 0.66% vs 2.27%; non-HBR, 0.43% vs 0.85%; P interaction = 0.36) (complex PCI, 0.63% vs 1.75%; noncomplex PCI, 0.48% vs 1.22%; P interaction = 0.90). The absolute difference in the bleeding between 1- and 12-month DAPT was numerically greater in patients with HBR than in those without HBR (-1.61% vs -0.42%). CONCLUSIONS: The effects of 1-month DAPT relative to 12-month DAPT were consistent regardless of HBR and complex PCI. The absolute benefit of 1-month DAPT over 12-month DAPT in reducing major bleeding was numerically greater in

application/pdf, Tick-borne diseases (TBDs) restrict livestock farming and have significant economic impact in sub-Saharan Africa. In endemic areas livestock are exposed to different tick species carrying various pathogens and they transmit them to livestock. Small ruminants in Sahel region plays important role in human livelihood, however, there is scarcity of information on the TBDs epidemiology in this region. Therefore, our study was aimed at providing an overview of the occurrence of TBDs in Seno and Oudalan provinces of Burkina Faso. We used PCR and sequencing to analyze 79 blood samples collected from sheep and goats to detect the tick-borne pathogens (TBPs). The PCR assays used to analyze samples were targeting Theileria ovis SSU rRNA, Ehrlichia ruminantium pCS20, Anaplasma ovis AoMSP4, Anaplasma phagocytophilum Epank1, Babesia ovis SSU rRNA and Theileria spp. 18S rRNA genes. PCR screening revealed that T. ovis and A. ovis were the only pathogens detected in this study. The prevalence rates for T. ovis and A. ovis were 29/79 (36.7%) and 33/79 (41.8%), respectively. Mixed infections were detected in 22/79 (27.9%) samples of this study. Sequence analysis of T. ovis SSU rRNA gene indicated that the gene is conserved among T. ovis isolates in the study area with sequence identity values of 100%. The A. ovis AoMSP4 gene sequences showed that the gene is conserved among the A. ovis isolates in the study area with the sequence identity values of 100%. All A. ovis appeared in the same clade on a phylogenetic tree based on AoMSP4 gene sequences. Likewise, the T. ovis sequences of this study appeared in the same clade of the phylogenetic tree based on SSU rRNA gene. This study provides an overview of the presence of important tick-borne pathogens in small ruminants of Seno and Oudalan provinces of Burkina Faso.

The gradient flow exact renormalization group (GFERG) is an idea that incorporates gauge invariant gradient flows into the formalism of the exact renormalization group (ERG). GFERG introduces a Wilson action with a cutoff while keeping vector gauge invariance manifestly. The details of the formalism are still to be worked out. In this paper, we apply GFERG to construct the Wilson action of massless Dirac fermions under the background chiral gauge fields. By formulating the chiral anomaly as a ``composite operator,'' we make the scale invariance of the anomaly manifest. We argue that the same result extends to QCD., Comment: 25 pages

In this talk, we give the lattice regularized formulation of the mixed 't Hooft anomaly between the $\mathbb{Z}_N$ $1$-form symmetry and the $\theta$ periodicity for $4$d pure Yang-Mills theory, which was originally discussed by Gaiotto $\textit{et al.}$ in the continuum description. For this purpose, we define the topological charge of the lattice $SU(N)$ gauge theory coupled with the background $\mathbb{Z}_N$ $2$-form gauge fields $B_p$ by generalizing L\"uscher's construction of the $SU(N)$ topological charge. We show that this lattice topological charge enjoys the fractional $1/N$ shift completely characterized by the background gauge field $B_p$, and this rigorously proves the mixed 't Hooft anomaly with the finite lattice spacings. As a consequence, the Yang-Mills vacua at $\theta$ and $\theta+2\pi$ are distinct as the symmetry-protected topological states when the confinement is assumed., Comment: 8 pages, 2 figures, talk presented at the 40th International Symposium on Lattice Field Theory (Lattice2023), July 31st - August 4th, 2023, Fermi National Accelerator Laboratory

In lattice compact gauge theories, we must impose the admissibility condition to have well-defined topological sectors. The admissibility condition, however, usually forbids the presence of magnetic operators, and it is not so trivial if one can study the monopole physics depending on the topological term, such as the Witten effect, on the lattice. In this paper, we address this question in the case of 2D compact scalars as it would be one of the simplest examples having analogues of the monopole and the topological term. To define the magnetic operator, we propose the ``excision method,'' which consists of excising lattice links (or bonds) in an appropriate region containing the monopole and defining the dual lattice in a particular way. The size of the excised region is $O(1)$ in lattice units so that the monopole becomes point-like in the continuum limit. We give the lattice derivation of the 't~Hooft anomalies between the electric and magnetic symmetries and also derive the higher-group-like structure related to the Witten effect., Comment: 21 pages, 4 figures

We extend the definition of L\"uscher's lattice topological charge to the case of $4$d $SU(N)$ gauge fields coupled with $\mathbb{Z}_N$ $2$-form gauge fields. This result is achieved while maintaining the locality, the $SU(N)$ gauge invariance, and $\mathbb{Z}_N$ $1$-form gauge invariance, and we find that the manifest $1$-form gauge invariance plays the central role in our construction. This result gives the lattice regularized derivation of the mixed 't Hooft anomaly in pure $SU(N)$ Yang-Mills theory between its $\mathbb{Z}_N$ $1$-form symmetry and the $\theta$ periodicity., Comment: 20 pages, 3 figures; (v2) minor improvements, refs updated

We define a one-particle irreducible (1PI) Wilson action in the gradient flow exact renormalization group (GFERG) formalism as the Legendre transform of a Wilson action. We consider quantum electrodynamics in particular, and show that the GFERG flow equation preserves the invariance of the 1PI Wilson action (excluding the gauge-fixing term) under the \emph{conventional\/} $U(1)$ gauge transformation. This is in contrast to the invariance of the original Wilson action under a modified $U(1)$ gauge transformation. The global chiral transformation also takes the \emph{conventional\/} form for the 1PI Wilson action. Despite the complexity of the GFERG flow equation, the conventional form of the gauge and global chiral transformations may allow us to introduce a non-perturbative Ansatz for gauge and chiral invariant 1PI Wilson actions., Comment: 21 pages, the final version to appear in PTEP

We have studied several protecting groups for vinylboronic-acid derivatives as monomers in radical polymerizations with the objective to improve the polymerization ability and C–B bond-cleaving post-transformation performance. Anthranilamide (aam)-protected vinylboronic acid (VBaam) exhibited experimentally a relatively high polymerization activity, which was theoretically corroborated by density functional theory (DFT) calculations that revealed a peculiar effect of the interaction between the aam groups on the polymerization behavior. The VBaam units in the copolymers can subsequently be transformed into vinyl alcohols or into ethylene units through C–B-bond-cleaving side-chain replacement, which affords valuable copolymers such as poly(vinyl alcohol-co-styrene), poly(ethylene-co-styrene), and poly(ethylene-co-acrylate).

[Background] The development of orphan drugs (ODs) is challenging from both development and business perspectives because of their small patient populations. To overcome such business challenges, lifecycle management (LCM), which maximizes profits by increasing sales and extending product lifetimes, is important to overcome the business challenges arising from their small patient populations. To clarify the activities of the LCM of ODs, we investigated additional indications that contribute to market expansion and marketing exclusivity using the patent extension and re-examination system of ODs approved in Japan between 2004 and 2019. [Results] The 203 ODs consisting of 173 active ingredients were approved in Japan between 2004 and 2019. Sixty-eight (39%) of the 173 active ingredients have additional indications, of which 57 have at least one non-OD indication. Three-fourths of the 203 ODs had patent rights, and most of them included substance or use claims. Although the re-examination period for most ODs was 10 years after the approval, most patents had a longer duration than the re-examination period. [Conclusions] Pharmaceutical companies were actively adding non-OD indications and were emphasizing the use of patent rights by registering extensions of substance or use patents for exclusive marketing periods. These results indicate that LCM through the addition of indications and registration of patent extensions is carried out as a strategy for many ODs in Japan, similar to the LCM of general non-ODs.

[Background:] The benefit of clopidogrel monotherapy after 1-month dual antiplatelet therapy (DAPT) compared with 12-month DAPT with aspirin and clopidogrel was demonstrated in the STOPDAPT-2 (Short and Optimal Duration of Dual Antiplatelet Therapy After Everolimus-Eluting Cobalt-Chromium Stent-2), but not in the STOPDAPT-2 acute coronary syndrome (ACS); however, both trials were underpowered based on the actual event rates. [Methods:] We obtained the prespecified pooled population of 5997 patients as the STOPDAPT-2 total cohort (STOPDAPT-2: N=3009/STOPDAPT-2 ACS: N=2988; ACS: N=4136/chronic coronary syndrome [CCS]: N=1861), comprising 2993 patients assigned to 1-month DAPT followed by clopidogrel monotherapy, and 3004 patients assigned to 12-month DAPT with aspirin and clopidogrel after percutaneous coronary intervention. The primary end point was the composite of cardiovascular (cardiovascular death, myocardial infarction, definite stent thrombosis, or any stroke) or bleeding (Thrombolysis in Myocardial Infarction major/minor) end points at 1 year. [Results:] One-month DAPT was noninferior to 12-month DAPT for the primary end point (2.84% versus 3.04%; hazard ratio [HR], 0.94 [95% CI, 0.70–1.27]; Pnoninferiority=0.001; Psuperiority=0.68). There was no significant risk-difference for the cardiovascular end point between the 1- and 12-month DAPT groups (2.40% versus 1.97%; HR, 1.24 [95% CI, 0.88–1.75]; Pnoninferiority=0.14; Psuperiority=0.23). There was a lower risk of the bleeding end point with 1-month DAPT relative to 12-month DAPT (0.50% versus 1.31%; HR, 0.38 [95% CI, 0.21–0.70]; Psuperiority=0.002). One-month DAPT relative to 12-month DAPT was associated with a lower risk for major bleeding regardless of ACS or CCS (ACS: HR, 0.46 [95% CI, 0.23–0.94]; P=0.03, and CCS: HR, 0.26 [95% CI, 0.09–0.79]; P=0.02; Pinteraction=0.40), while it was associated with a numerical increase in cardiovascular events in ACS patients, but not in CCS patients, although not statisti

We define a one-particle irreducible (1PI) Wilson action in the gradient flow exact renormalization group (GFERG) formalism as the Legendre transform of a Wilson action. We consider quantum electrodynamics in particular, and show that the GFERG flow equation preserves the invariance of the 1PI Wilson action (excluding the gauge-fixing term) under the \emph{conventional\/} $U(1)$ gauge transformation. This is in contrast to the invariance of the original Wilson action under a modified $U(1)$ gauge transformation. The global chiral transformation also takes the \emph{conventional\/} form for the 1PI Wilson action. Despite the complexity of the GFERG flow equation, the conventional form of the gauge and global chiral transformations may allow us to introduce a non-perturbative Ansatz for gauge and chiral invariant 1PI Wilson actions., Comment: 21 pages, the final version to appear in PTEP

Modern theories of physics tell that the vacuum is not an empty space. Hidden in the vacuum is a structure of anti-quarks $\bar{q}$ and quarks $q$. The $\bar{q}$ and $q$ pair has the same quantum number as the vacuum and condensates in it since the strong interaction of the quantum chromodynamics (QCD) is too strong to leave it empty. The $\bar{q}q$ condensation breaks the chiral symmetry of the vacuum. The expectation value $<\bar{q}q>$ is an order parameter. For higher temperature or higher matter-density, $|<\bar{q}q>|$ decreases reflecting the restoration of the symmetry. In contrast to these clear-cut arguments, experimental evidence is so far limited. First of all, the $\bar{q}q$ is nothing but the vacuum itself. It is neither visible nor perceptible. In this article, we unravel this invisible existence by high precision measurement of pionic atoms, $\pi^-$-meson-nucleus bound systems. Using the $\pi^-$ as a probe, we demonstrate that $|<\bar{q}q>|$ is reduced in the nucleus by a factor of 58 $\pm$ 4% compared with that in the vacuum. This reduction indicates that the chiral symmetry is partially restored due to the extremely high density of the nucleus. The present experimental result clearly exhibits the existence of the hidden structure, the chiral condensate, in the vacuum.

We construct a non-trivial $U(1)/\mathbb{Z}_q$ principal bundle on~$T^4$ from the compact $U(1)$ lattice gauge field by generalizing L\"uscher's constriction so that the cocycle condition contains $\mathbb{Z}_q$ elements (the 't~Hooft flux). The construction requires an admissibility condition on lattice gauge field configurations. From the transition function so constructed, we have the fractional topological charge that is $\mathbb{Z}_q$ one-form gauge invariant and odd under the lattice time reversal transformation. Assuming a rescaling of the vacuum angle $\theta\to q\theta$ suggested from the Witten effect, our construction provides a lattice implementation of the mixed 't~Hooft anomaly between the $\mathbb{Z}_q$ one-form symmetry and the time reversal symmetry in the $U(1)$ gauge theory with matter fields of charge~$q\in2\mathbb{Z}$ when $\theta=\pi$, which was studied by Honda and Tanizaki [J. High Energy Phys. \textbf{12}, 154 (2020)] in the continuum framework., Comment: 18 pages. The final version to appear in PTEP

In this paper, we propose a cloud distribution prediction model in which fully convolutional networks are used to improve the prediction accuracy for photovoltaic power generation systems. The model learns the cloud distribution from meteorological satellite images and predicts the cloud image 60 min later. We examined the applicability of Day Microphysics RGB as input to the cloud image prediction model. Day Microphysics RGB is a type of RGB composite image based on the observation image of Himawari-8. It is used for daytime cloud analysis and can perform detailed cloud analysis, for example, the discrimination of cloud areas such as upper and lower clouds. The performance of the proposed method is evaluated on the basis of the root mean square error of the prediction and ground truth images.

We performed aneurysm repair with double closure technique of sinus of Valsalva aneurysm（SVA）in a 59-year-old man who was revealed obstructing right ventricular outflow tract（RVOT）with moderate Aortic insufficiency（AI）by transthoracic echocardiography（TTE）. SVA plication was performed resection and suture trans tricuspid valve. Patch closure was performed with double-layer 30mm×30mm bovine pericardial patch. Aortic valve cusps had no abnormalities such as prolapse and AI disappeared after aneurysm repair because the etiology of AI was enlargement of aortic valve annulus. He was discharged with good condition. Computed tomography confirmed disappearance of blood flow in SVA, and TTE showed released RVOT obstruction in follow-up. Double closure technique, which combines resection and suture and patch closure, is useful for treatment of SVA.

Abnormalities in the regulation of gene expression are associated with various pathological conditions. Among the distal regulatory elements in the genome, the activation of target genes by enhancers plays a central role in the formation of cell type–specific gene expression patterns. Super-enhancers are a subclass of enhancers that frequently contain multiple enhancer-like elements and are characterized by dense binding of master transcription factors and Mediator complexes and high signals of active histone marks. Super-enhancers have been studied in detail as important regulatory regions that control cell identity and contribute to the pathogenesis of diverse diseases. In cancer, super-enhancers have multifaceted roles by activating various oncogenes and other cancer-related genes and shaping characteristic gene expression patterns in cancer cells. Alterations in super-enhancer activities in cancer involve multiple mechanisms, including the dysregulation of transcription factors and the super-enhancer–associated genomic abnormalities. The study of super-enhancers could contribute to the identification of effective biomarkers and the development of cancer therapeutics targeting transcriptional addiction. In this review, we summarize the roles of super-enhancers in cancer biology, with a particular focus on hematopoietic malignancies, in which multiple super-enhancer alteration mechanisms have been reported.

We describe a leaf region detection and leaf area calculation algorithm for estimating the growing conditions of small tomatoes. In leaf region detection, a color image taken by a depth camera is analyzed by image processing. The leaf region is divided into more than one hundred quadrangle meshs, and the spatial coordinates of the vertices of the mesh are calculated from the depth information obtained by the depth camera. To reduce the effect of measurement noise, an approximate surface expressed by a two-variable quadratic function is obtained, and the leaf area is calculated as the sum of the area of the meshs on the approximate surface. In the experiment, the algorithm will be evaluated using leaf measurements of small tomatoes in a greenhouse.

We construct a non-trivial $U(1)/\mathbb{Z}_q$ principal bundle on~$T^4$ from the compact $U(1)$ lattice gauge field by generalizing L\"uscher's constriction so that the cocycle condition contains $\mathbb{Z}_q$ elements (the 't~Hooft flux). The construction requires an admissibility condition on lattice gauge field configurations. From the transition function so constructed, we have the fractional topological charge that is $\mathbb{Z}_q$ one-form gauge invariant and odd under the lattice time reversal transformation. Assuming a rescaling of the vacuum angle $\theta\to q\theta$ suggested from the Witten effect, our construction provides a lattice implementation of the mixed 't~Hooft anomaly between the $\mathbb{Z}_q$ one-form symmetry and the time reversal symmetry in the $U(1)$ gauge theory with matter fields of charge~$q\in2\mathbb{Z}$ when $\theta=\pi$, which was studied by Honda and Tanizaki [J. High Energy Phys. \textbf{12}, 154 (2020)] in the continuum framework., Comment: 18 pages. The final version to appear in PTEP

We study phase structure and critical point of finite-temperature QCD in the heavy-quark region applying the hopping parameter expansion (HPE). We first study finite-size scaling on the critical point on $N_t=4$ lattices with large spatial volumes taking the leading order (LO) and the next-to-leading order (NLO) effects of the HPE, and find that the critical scaling of the Z(2) universality class expected around the critical point of two-flavor QCD is realized when the aspect ratio of the lattice is larger than about 9. This enables us to determine the critical point in the thermodynamic limit with high precisions. By a study of the convergence of the HPE, we confirm that the result of the critical point with the LO (NLO) approximation of the HPE is fairly accurate for $N_t=4$ (6), while we need to incorporate higher order effects for larger $N_t$. To extend the study to large $N_t$ lattices, we then develop a method to take the effects of higher-order terms of the HPE up to a sufficiently high order. We report on the status of our study on $N_t = 6$ lattice adopting the new method., Comment: 9 pages, 5 figures, Proceedings of the 39th International Symposium on Lattice Field Theory (LATTICE2022), 8th-13th August 2022, Bonn, Germany

We define a one-particle irreducible (1PI) Wilson action in the gradient flow exact renormalization group (GFERG) formalism as the Legendre transform of a Wilson action. We consider quantum electrodynamics in particular, and show that the GFERG flow equation preserves the invariance of the 1PI Wilson action (excluding the gauge-fixing term) under the \emph{conventional\/} $U(1)$ gauge transformation. This is in contrast to the invariance of the original Wilson action under a modified $U(1)$ gauge transformation. The global chiral transformation also takes the \emph{conventional\/} form for the 1PI Wilson action. Despite the complexity of the GFERG flow equation, the conventional form of the gauge and global chiral transformations may allow us to introduce a non-perturbative Ansatz for gauge and chiral invariant 1PI Wilson actions., Comment: 21 pages, the final version to appear in PTEP

We describe a leaf region detection and leaf area calculation algorithm for estimating the growing conditions of small tomatoes. In leaf region detection, a color image taken by a depth camera is analyzed by image processing. The leaf region is divided into more than one hundred quadrangle meshs, and the spatial coordinates of the vertices of the mesh are calculated from the depth information obtained by the depth camera. To reduce the effect of measurement noise, an approximate surface expressed by a two-variable quadratic function is obtained, and the leaf area is calculated as the sum of the area of the meshs on the approximate surface. In the experiment, the algorithm will be evaluated using leaf measurements of small tomatoes in a greenhouse.

In this paper, we propose a cloud distribution prediction model in which fully convolutional networks are used to improve the prediction accuracy for photovoltaic power generation systems. The model learns the cloud distribution from meteorological satellite images and predicts the cloud image 60 min later. We examined the applicability of Day Microphysics RGB as input to the cloud image prediction model. Day Microphysics RGB is a type of RGB composite image based on the observation image of Himawari-8. It is used for daytime cloud analysis and can perform detailed cloud analysis, for example, the discrimination of cloud areas such as upper and lower clouds. The performance of the proposed method is evaluated on the basis of the root mean square error of the prediction and ground truth images.

We construct a non-trivial $U(1)/\mathbb{Z}_q$ principal bundle on~$T^4$ from the compact $U(1)$ lattice gauge field by generalizing L\"uscher's constriction so that the cocycle condition contains $\mathbb{Z}_q$ elements (the 't~Hooft flux). The construction requires an admissibility condition on lattice gauge field configurations. From the transition function so constructed, we have the fractional topological charge that is $\mathbb{Z}_q$ one-form gauge invariant and odd under the lattice time reversal transformation. Assuming a rescaling of the vacuum angle $\theta\to q\theta$ suggested from the Witten effect, our construction provides a lattice implementation of the mixed 't~Hooft anomaly between the $\mathbb{Z}_q$ one-form symmetry and the time reversal symmetry in the $U(1)$ gauge theory with matter fields of charge~$q\in2\mathbb{Z}$ when $\theta=\pi$, which was studied by Honda and Tanizaki [J. High Energy Phys. \textbf{12}, 154 (2020)] in the continuum framework., Comment: 18 pages. The final version to appear in PTEP

We study phase structure and critical point of finite-temperature QCD in the heavy-quark region applying the hopping parameter expansion (HPE). We first study finite-size scaling on the critical point on $N_t=4$ lattices with large spatial volumes taking the leading order (LO) and the next-to-leading order (NLO) effects of the HPE, and find that the critical scaling of the Z(2) universality class expected around the critical point of two-flavor QCD is realized when the aspect ratio of the lattice is larger than about 9. This enables us to determine the critical point in the thermodynamic limit with high precisions. By a study of the convergence of the HPE, we confirm that the result of the critical point with the LO (NLO) approximation of the HPE is fairly accurate for $N_t=4$ (6), while we need to incorporate higher order effects for larger $N_t$. To extend the study to large $N_t$ lattices, we then develop a method to take the effects of higher-order terms of the HPE up to a sufficiently high order. We report on the status of our study on $N_t = 6$ lattice adopting the new method., Comment: 9 pages, 5 figures, Proceedings of the 39th International Symposium on Lattice Field Theory (LATTICE2022), 8th-13th August 2022, Bonn, Germany

We define a one-particle irreducible (1PI) Wilson action in the gradient flow exact renormalization group (GFERG) formalism as the Legendre transform of a Wilson action. We consider quantum electrodynamics in particular, and show that the GFERG flow equation preserves the invariance of the 1PI Wilson action (excluding the gauge-fixing term) under the \emph{conventional\/} $U(1)$ gauge transformation. This is in contrast to the invariance of the original Wilson action under a modified $U(1)$ gauge transformation. The global chiral transformation also takes the \emph{conventional\/} form for the 1PI Wilson action. Despite the complexity of the GFERG flow equation, the conventional form of the gauge and global chiral transformations may allow us to introduce a non-perturbative Ansatz for gauge and chiral invariant 1PI Wilson actions., Comment: 21 pages, the final version to appear in PTEP

© 2018 National Academy of Sciences. All rights reserved. A hallmark of biological systems is that particular functions and outcomes are realized in specific contexts, such as when particular signals are received. One mechanism for mediating specificity is described by Fisher’s “lock and key” metaphor, exemplified by enzymes that bind selectively to a particular substrate via specific finely tuned interactions. Another mechanism, more prevalent in multicellular organisms, relies on multivalent weak cooperative interactions. Its importance has recently been illustrated by the recognition that liquid-liquid phase transitions underlie the formation of mem-braneless condensates that perform specific cellular functions. Based on computer simulations of an evolutionary model, we report that the latter mechanism likely became evolutionarily prominent when a large number of tasks had to be performed specifically for organisms to function properly. We find that the emergence of weak cooperative interactions for mediating specificity results in organisms that can evolve to accomplish new tasks with fewer, and likely less lethal, mutations. We argue that this makes the system more capable of undergoing evolutionary changes robustly, and thus this mechanism has been repeatedly positively selected in increasingly complex organisms. Specificity mediated by weak cooperative interactions results in some useful cross-reactivity for related tasks, but at the same time increases susceptibility to misregulation that might lead to pathologies.

We formulate quantum electrodynamics on the basis of gauge (or BRST) covariant diffusion equations of fields. This is a particular example of the gradient flow exact renormalization group (GFERG). The resulting Wilson action fulfills a simple gauge Ward--Takahashi identity. We solve the GFERG equation around the Gaussian fixed point to the second order in gauge coupling and obtain the 1-loop beta function and anomalous dimensions. The anomalous dimension of the electron field coincides with that of the fermion field diffused by a gauge covariant flow equation of L\"uscher., Comment: 37 pages

The gradient flow exact renormalization group (GFERG) is an exact renormalization group motivated by the Yang--Mills gradient flow and its salient feature is a manifest gauge invariance. We generalize this GFERG, originally formulated for the pure Yang--Mills theory, to vector-like gauge theories containing fermion fields, keeping the manifest gauge invariance. For the chiral symmetry we have two options: one possible formulation preserves the conventional form of the chiral symmetry and the other simpler formulation realizes the chiral symmetry in a modified form \`a la Ginsparg--Wilson. We work out a gauge-invariant local Wilson action in quantum electrodynamics to the lowest nontrivial order of perturbation theory. This Wilson action reproduces the correct axial anomaly in~$D=2$., Comment: 23 pages, the final version to appear in PTEP

We formulate quantum electrodynamics on the basis of gauge (or BRST) covariant diffusion equations of fields. This is a particular example of the gradient flow exact renormalization group (GFERG). The resulting Wilson action fulfills a simple gauge Ward--Takahashi identity. We solve the GFERG equation around the Gaussian fixed point to the second order in gauge coupling and obtain the 1-loop beta function and anomalous dimensions. The anomalous dimension of the electron field coincides with that of the fermion field diffused by a gauge covariant flow equation of L\"uscher., Comment: 37 pages

We study the latent heat and the pressure gap between the hot and cold phases at the first-order transition temperature $T=T_c$ of SU(3) Yang-Mills theory, using the small flow-time expansion (SF$t$X) method based on the gradient flow. We first examine alternative procedures in the SFtX method -- the order of the continuum and vanishing flow-time extrapolations. We confirm that the final results adopting the two orders, as well as other alternatives in which the perturbative order of the matching coefficients and the renormalization scale of the flow scheme are varied, are all consistent with each other. We also confirm $\Delta p$ is consistent with zero, as expected from the dynamical balance of two phases at $T_c$. For the latent heat in the continuum limit, we find $\Delta \epsilon /T^4 = 1.117(40)$ for the spatial volume $L^3$ corresponding to the aspect ratio $N_s/N_t=T_cL=8$ and $1.349(38)$ for $N_s/N_t=6$. From hysteresis curves, we show that the entropy density in the hot phase is sensitive to the spatial volume, while that in the confined phase is insensitive., Comment: 9 pages, 6 figures, poster presented at the 38th International Symposium on Lattice Field Theory (Lattice 2021), July 26-30 2021, Zoom/Gather@MIT, USA

We theoretically clarify the functional form to be used in $t \to 0$ extrapolation in the small flow time expansion (SF$t$X) method for the energy-momentum tensor (EMT), which facilitates lattice simulation of the EMT based on the gradient flow. We argue that in the $t \to 0$ extrapolation analysis, lattice data should be fitted by a power function in $g(\mu(t))$, the flow time dependent running coupling, where the power is determined by the perturbation order we consider. From actual lattice data, we confirm the validity of the extrapolation function. Using the new extrapolation function, we present updated lattice results for thermodynamics quantities in quenched QCD; our results are consistent with the previous study [arXiv:1812.06444] but we obtain smaller errors due to reduction of systematic errors., Comment: 46 pages, 8 figures, version to appear in PTEP

The gradient flow exact renormalization group (GFERG) is an exact renormalization group motivated by the Yang--Mills gradient flow and its salient feature is a manifest gauge invariance. We generalize this GFERG, originally formulated for the pure Yang--Mills theory, to vector-like gauge theories containing fermion fields, keeping the manifest gauge invariance. For the chiral symmetry we have two options: one possible formulation preserves the conventional form of the chiral symmetry and the other simpler formulation realizes the chiral symmetry in a modified form \`a la Ginsparg--Wilson. We work out a gauge-invariant local Wilson action in quantum electrodynamics to the lowest nontrivial order of perturbation theory. This Wilson action reproduces the correct axial anomaly in~$D=2$., Comment: 23 pages, the final version to appear in PTEP

We formulate quantum electrodynamics on the basis of gauge (or BRST) covariant diffusion equations of fields. This is a particular example of the gradient flow exact renormalization group (GFERG). The resulting Wilson action fulfills a simple gauge Ward--Takahashi identity. We solve the GFERG equation around the Gaussian fixed point to the second order in gauge coupling and obtain the 1-loop beta function and anomalous dimensions. The anomalous dimension of the electron field coincides with that of the fermion field diffused by a gauge covariant flow equation of L\"uscher., Comment: 37 pages

The gradient flow exact renormalization group (GFERG) is an exact renormalization group motivated by the Yang--Mills gradient flow and its salient feature is a manifest gauge invariance. We generalize this GFERG, originally formulated for the pure Yang--Mills theory, to vector-like gauge theories containing fermion fields, keeping the manifest gauge invariance. For the chiral symmetry we have two options: one possible formulation preserves the conventional form of the chiral symmetry and the other simpler formulation realizes the chiral symmetry in a modified form \`a la Ginsparg--Wilson. We work out a gauge-invariant local Wilson action in quantum electrodynamics to the lowest nontrivial order of perturbation theory. This Wilson action reproduces the correct axial anomaly in~$D=2$., Comment: 23 pages, the final version to appear in PTEP

In this paper, we describe a tomato recognition algorithm and a fruit grasping mechanism for a tomato-harvesting robot that is designed to operate in a horticultural facility. In the tomato recognition algorithm, image processing is performed on the color images captured by a depth camera to detect red ripe large tomato and oval mini-tomato fruits. Then, the spatial coordinates of the fruit center and the diameter of the fruit are calculated using the depth information acquired by the depth camera. For the grasping mechanism, we designed and fabricated a mechanism for grasping an oval mini-tomato, which is necessary in the harvesting process. Experiments using these systems were conducted in a horticultural facility where tomatoes are grown, and the performances of both the tomato recognition and grasping motions were verified.

In this study, we propose a method to estimate the assistive timing requirements for a power-assisted lumbar suit based on upper-body acceleration. Our developed power-assisted suit combines of springs, wires, and an electrical motor to provide efficient assistance. The assistive torque provided by the suit was determined based on a digital human model. The assistive timing using the electrical motor was calculated from the upper-body acceleration measured using two internal accelerometers. Herein, we present the experimental results based on the myoelectricity of a muscle during lifting motions involving three participants acting as caregivers to elderly patients.

We study the latent heat and the pressure gap between the hot and cold phases at the first-order transition temperature $T=T_c$ of SU(3) Yang-Mills theory, using the small flow-time expansion (SF$t$X) method based on the gradient flow. We first examine alternative procedures in the SFtX method -- the order of the continuum and vanishing flow-time extrapolations. We confirm that the final results adopting the two orders, as well as other alternatives in which the perturbative order of the matching coefficients and the renormalization scale of the flow scheme are varied, are all consistent with each other. We also confirm $\Delta p$ is consistent with zero, as expected from the dynamical balance of two phases at $T_c$. For the latent heat in the continuum limit, we find $\Delta \epsilon /T^4 = 1.117(40)$ for the spatial volume $L^3$ corresponding to the aspect ratio $N_s/N_t=T_cL=8$ and $1.349(38)$ for $N_s/N_t=6$. From hysteresis curves, we show that the entropy density in the hot phase is sensitive to the spatial volume, while that in the confined phase is insensitive., Comment: 9 pages, 6 figures, poster presented at the 38th International Symposium on Lattice Field Theory (Lattice 2021), July 26-30 2021, Zoom/Gather@MIT, USA

We theoretically clarify the functional form to be used in $t \to 0$ extrapolation in the small flow time expansion (SF$t$X) method for the energy-momentum tensor (EMT), which facilitates lattice simulation of the EMT based on the gradient flow. We argue that in the $t \to 0$ extrapolation analysis, lattice data should be fitted by a power function in $g(\mu(t))$, the flow time dependent running coupling, where the power is determined by the perturbation order we consider. From actual lattice data, we confirm the validity of the extrapolation function. Using the new extrapolation function, we present updated lattice results for thermodynamics quantities in quenched QCD; our results are consistent with the previous study [arXiv:1812.06444] but we obtain smaller errors due to reduction of systematic errors., Comment: 46 pages, 8 figures, version to appear in PTEP