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Identifying critical soil erosion areas and sediment sources are essential for sediment control and water resources management in the watershed, especially in the severely eroded northern Loess Plateau, China. In this study, we collected suspended sediment samples at the hydrological stations to identify the sediment source dynamics during flood events in a highly erodible basin, the Huangfu River basin in the Northern Loess Plateau. A total of 6 flood events were sampled during 2016 and 2018 for investigation, the flow discharge was featured by a rapid rising limb and a slow falling limb. Compared with the sediment sources, the silt fraction in the suspended sediments was enriched and the sand fraction in the suspended sediment was depleted. The dominant particle grain size of suspended sediments was coarse sand (56.89%), higher than silt (41.81%) and clay (1.3%). The sediment sources were estimated using the FingerPro unmixing model based on the conservativeness index (CI) and consensus ranking (CR) methods. The results of the unmixing model reveal that the bare land was the predominant source of suspended sediments, ranging from 40% to 57%, which was much higher than farmland (27 ∼ 31%) and grassland (16 ∼ 25%). Our findings imply that the bare land (weathered sandstone area) is the critical region for soil loss control in the Huangfu River basin. A combination of vegetation restoration measures and engineering measures are proposed to improve the sustainable development of ecological environment in the basin.

[ES] El objetivo del presente Trabajo Fin de Máster es el diseño de un centro de distribución para una empresa del sector de moda deportiva, con el fin de permitir el abastecimiento a nivel nacional de sus tiendas de venta al público. Dado que no existe un procedimiento universal para el diseño de centros de distribución, se opta por una metodología iterativa de diseño que permita satisfacer una serie de requisitos analizados y establecidos por la empresa, como son los niveles de inventario, los perfiles de preparación de pedidos, las características de los productos y la inversión del proyecto. Para llevar a cabo el diseño, primero se deben analizar las condiciones que se exigen cumplir con la actividad de la empresa. A partir de los datos obtenidos, se procede a definir una primera configuración en la que se realiza el dimensionamiento de los medios de almacenamiento, la definición del modelo de funcionamiento para el centro de distribución, el dimensionamiento de los medios de manutención, la distribución en planta, la estimación de costes operativos, la inversión necesaria y la determinación de los procesos operativos. Tras ello, se hace un análisis de la configuración obtenida y se identifican otras alternativas para tratar de optimizar el diseño, modificando las decisiones de diseño y repitiendo el procedimiento explicado anteriormente. Por último, a través de las sucesivas iteraciones, en las que también se evalúa económicamente cada una de las opciones de diseño, se selecciona una solución final que cumpla con los requisitos establecidos por la empresa y que además proporcione los menores costes anuales y la menor inversión., [EN] The objective of this Master's Thesis is the design of a distribution center for a company in the sports fashion sector, in order to allow the nationwide supply of its retail stores. Since there is no universal method for the design of distribution centers, an iterative design methodology is chosen which enables to provide a series of analyzed requirements and established by the company, such as inventory levels, order preparation profiles, the characteristics of the products and the investment of the project. To accomplish the design, first, the conditions that are required to fulfill the activity of the company must be analyzed. From the obtained data, it is proceeded to define a first configuration in which is done the sizing of the storage media, the definition of the operating model for the distribution center, the sizing of the handling media, the layout, the estimation of operating costs, the necessary investment and the determination of the operating processes. After that, it is made an analysis of the configuration obtained and it is identified other alternatives to try to optimize the design, modifying the design decisions and repeating the procedure explained above. Finally, through successive iterations, in which each of the design options is also economically evaluated, a final solution is selected that meets the requirements established by the company and that also provides the lowest annual costs and the lowest investment.

[ES] El objetivo del presente Trabajo Fin de Máster es el diseño de un centro de distribución para una empresa del sector de moda deportiva, con el fin de permitir el abastecimiento a nivel nacional de sus tiendas de venta al público. Dado que no existe un procedimiento universal para el diseño de centros de distribución, se opta por una metodología iterativa de diseño que permita satisfacer una serie de requisitos analizados y establecidos por la empresa, como son los niveles de inventario, los perfiles de preparación de pedidos, las características de los productos y la inversión del proyecto. Para llevar a cabo el diseño, primero se deben analizar las condiciones que se exigen cumplir con la actividad de la empresa. A partir de los datos obtenidos, se procede a definir una primera configuración en la que se realiza el dimensionamiento de los medios de almacenamiento, la definición del modelo de funcionamiento para el centro de distribución, el dimensionamiento de los medios de manutención, la distribución en planta, la estimación de costes operativos, la inversión necesaria y la determinación de los procesos operativos. Tras ello, se hace un análisis de la configuración obtenida y se identifican otras alternativas para tratar de optimizar el diseño, modificando las decisiones de diseño y repitiendo el procedimiento explicado anteriormente. Por último, a través de las sucesivas iteraciones, en las que también se evalúa económicamente cada una de las opciones de diseño, se selecciona una solución final que cumpla con los requisitos establecidos por la empresa y que además proporcione los menores costes anuales y la menor inversión., [EN] The objective of this Master's Thesis is the design of a distribution center for a company in the sports fashion sector, in order to allow the nationwide supply of its retail stores. Since there is no universal method for the design of distribution centers, an iterative design methodology is chosen which enables to provide a series of analyzed requirements and established by the company, such as inventory levels, order preparation profiles, the characteristics of the products and the investment of the project. To accomplish the design, first, the conditions that are required to fulfill the activity of the company must be analyzed. From the obtained data, it is proceeded to define a first configuration in which is done the sizing of the storage media, the definition of the operating model for the distribution center, the sizing of the handling media, the layout, the estimation of operating costs, the necessary investment and the determination of the operating processes. After that, it is made an analysis of the configuration obtained and it is identified other alternatives to try to optimize the design, modifying the design decisions and repeating the procedure explained above. Finally, through successive iterations, in which each of the design options is also economically evaluated, a final solution is selected that meets the requirements established by the company and that also provides the lowest annual costs and the lowest investment.

[ES] El objetivo del presente Trabajo Fin de Máster es el diseño de un centro de distribución para una empresa del sector de moda deportiva, con el fin de permitir el abastecimiento a nivel nacional de sus tiendas de venta al público. Dado que no existe un procedimiento universal para el diseño de centros de distribución, se opta por una metodología iterativa de diseño que permita satisfacer una serie de requisitos analizados y establecidos por la empresa, como son los niveles de inventario, los perfiles de preparación de pedidos, las características de los productos y la inversión del proyecto. Para llevar a cabo el diseño, primero se deben analizar las condiciones que se exigen cumplir con la actividad de la empresa. A partir de los datos obtenidos, se procede a definir una primera configuración en la que se realiza el dimensionamiento de los medios de almacenamiento, la definición del modelo de funcionamiento para el centro de distribución, el dimensionamiento de los medios de manutención, la distribución en planta, la estimación de costes operativos, la inversión necesaria y la determinación de los procesos operativos. Tras ello, se hace un análisis de la configuración obtenida y se identifican otras alternativas para tratar de optimizar el diseño, modificando las decisiones de diseño y repitiendo el procedimiento explicado anteriormente. Por último, a través de las sucesivas iteraciones, en las que también se evalúa económicamente cada una de las opciones de diseño, se selecciona una solución final que cumpla con los requisitos establecidos por la empresa y que además proporcione los menores costes anuales y la menor inversión., [EN] The objective of this Master's Thesis is the design of a distribution center for a company in the sports fashion sector, in order to allow the nationwide supply of its retail stores. Since there is no universal method for the design of distribution centers, an iterative design methodology is chosen which enables to provide a series of analyzed requirements and established by the company, such as inventory levels, order preparation profiles, the characteristics of the products and the investment of the project. To accomplish the design, first, the conditions that are required to fulfill the activity of the company must be analyzed. From the obtained data, it is proceeded to define a first configuration in which is done the sizing of the storage media, the definition of the operating model for the distribution center, the sizing of the handling media, the layout, the estimation of operating costs, the necessary investment and the determination of the operating processes. After that, it is made an analysis of the configuration obtained and it is identified other alternatives to try to optimize the design, modifying the design decisions and repeating the procedure explained above. Finally, through successive iterations, in which each of the design options is also economically evaluated, a final solution is selected that meets the requirements established by the company and that also provides the lowest annual costs and the lowest investment.

[ES] El objetivo del presente Trabajo Fin de Máster es el diseño de un centro de distribución para una empresa del sector de moda deportiva, con el fin de permitir el abastecimiento a nivel nacional de sus tiendas de venta al público. Dado que no existe un procedimiento universal para el diseño de centros de distribución, se opta por una metodología iterativa de diseño que permita satisfacer una serie de requisitos analizados y establecidos por la empresa, como son los niveles de inventario, los perfiles de preparación de pedidos, las características de los productos y la inversión del proyecto. Para llevar a cabo el diseño, primero se deben analizar las condiciones que se exigen cumplir con la actividad de la empresa. A partir de los datos obtenidos, se procede a definir una primera configuración en la que se realiza el dimensionamiento de los medios de almacenamiento, la definición del modelo de funcionamiento para el centro de distribución, el dimensionamiento de los medios de manutención, la distribución en planta, la estimación de costes operativos, la inversión necesaria y la determinación de los procesos operativos. Tras ello, se hace un análisis de la configuración obtenida y se identifican otras alternativas para tratar de optimizar el diseño, modificando las decisiones de diseño y repitiendo el procedimiento explicado anteriormente. Por último, a través de las sucesivas iteraciones, en las que también se evalúa económicamente cada una de las opciones de diseño, se selecciona una solución final que cumpla con los requisitos establecidos por la empresa y que además proporcione los menores costes anuales y la menor inversión., [EN] The objective of this Master's Thesis is the design of a distribution center for a company in the sports fashion sector, in order to allow the nationwide supply of its retail stores. Since there is no universal method for the design of distribution centers, an iterative design methodology is chosen which enables to provide a series of analyzed requirements and established by the company, such as inventory levels, order preparation profiles, the characteristics of the products and the investment of the project. To accomplish the design, first, the conditions that are required to fulfill the activity of the company must be analyzed. From the obtained data, it is proceeded to define a first configuration in which is done the sizing of the storage media, the definition of the operating model for the distribution center, the sizing of the handling media, the layout, the estimation of operating costs, the necessary investment and the determination of the operating processes. After that, it is made an analysis of the configuration obtained and it is identified other alternatives to try to optimize the design, modifying the design decisions and repeating the procedure explained above. Finally, through successive iterations, in which each of the design options is also economically evaluated, a final solution is selected that meets the requirements established by the company and that also provides the lowest annual costs and the lowest investment.

DiVA, Academic Archive On-line, is a website which can provide the information from the most academic publications of Swedish Universities. The information includes the title, author, publication data, and so on. The aim of this project is to design a tool to visualize the co-authorship publication network and be able to transform the data into a more readable form. For parsing and visualizing data, the tool adopts the “InforVis Reference” model. Here a set of interaction and visualization technologies are adopted, so that it can create view base on user’s query with increasing the usability. In this thesis, we present a “use case” by applying our tool to visualize a part of articles published at Linnaeus University and to illustrate the capability and functions of the tool. The tool can also provide user a comfortable operating environment with a quick searching speed and high efficiency; it can be used anywhere, if internet is available.

DiVA, Academic Archive On-line, is a website which can provide the information from the most academic publications of Swedish Universities. The information includes the title, author, publication data, and so on. The aim of this project is to design a tool to visualize the co-authorship publication network and be able to transform the data into a more readable form. For parsing and visualizing data, the tool adopts the “InforVis Reference” model. Here a set of interaction and visualization technologies are adopted, so that it can create view base on user’s query with increasing the usability. In this thesis, we present a “use case” by applying our tool to visualize a part of articles published at Linnaeus University and to illustrate the capability and functions of the tool. The tool can also provide user a comfortable operating environment with a quick searching speed and high efficiency; it can be used anywhere, if internet is available.

BackgroundProstate stem/progenitor cells function in glandular development and maintenance. They may be targets for tumor initiation, so characterization of these cells may have therapeutic implications. Cells from dissociated tissues that form spheres in vitro often represent stem/progenitor cells. A subset of human prostate cells that form prostaspheres were evaluated for self-renewal and tissue regeneration capability in the present study.MethodsProstaspheres were generated from 59 prostatectomy specimens. Lineage marker expression and TMPRSS-ERG status was determined via immunohistochemistry and fluorescence in situ hybridization (FISH). Subpopulations of prostate epithelial cells were isolated by cell sorting and interrogated for sphere-forming activity. Tissue regeneration potential was assessed by combining sphere-forming cells with rat urogenital sinus mesenchyme (rUGSM) subcutaneously in immunocompromised mice.ResultsProstate tissue specimens were heterogeneous, containing both benign and malignant (Gleason 3-5) glands. TMPRSS-ERG fusion was found in approximately 70% of cancers examined. Prostaspheres developed from single cells at a variable rate (0.5-4%) and could be serially passaged. A basal phenotype (CD44+CD49f+CK5+p63+CK8-AR-PSA-) was observed among sphere-forming cells. Subpopulations of prostate cells expressing tumor-associated calcium signal transducer 2 (Trop2), CD44, and CD49f preferentially formed spheres. In vivo implantation of sphere-forming cells and rUGSM regenerated tubular structures containing discreet basal and luminal layers. The TMPRSS-ERG fusion was absent in prostaspheres derived from fusion-positive tumor tissue, suggesting a survival/growth advantage of benign prostate epithelial cells.ConclusionHuman prostate sphere-forming cells self-renew, have tissue regeneration capability, and represent a subpopulation of basal cells.

BackgroundProstate stem/progenitor cells function in glandular development and maintenance. They may be targets for tumor initiation, so characterization of these cells may have therapeutic implications. Cells from dissociated tissues that form spheres in vitro often represent stem/progenitor cells. A subset of human prostate cells that form prostaspheres were evaluated for self-renewal and tissue regeneration capability in the present study.MethodsProstaspheres were generated from 59 prostatectomy specimens. Lineage marker expression and TMPRSS-ERG status was determined via immunohistochemistry and fluorescence in situ hybridization (FISH). Subpopulations of prostate epithelial cells were isolated by cell sorting and interrogated for sphere-forming activity. Tissue regeneration potential was assessed by combining sphere-forming cells with rat urogenital sinus mesenchyme (rUGSM) subcutaneously in immunocompromised mice.ResultsProstate tissue specimens were heterogeneous, containing both benign and malignant (Gleason 3-5) glands. TMPRSS-ERG fusion was found in approximately 70% of cancers examined. Prostaspheres developed from single cells at a variable rate (0.5-4%) and could be serially passaged. A basal phenotype (CD44+CD49f+CK5+p63+CK8-AR-PSA-) was observed among sphere-forming cells. Subpopulations of prostate cells expressing tumor-associated calcium signal transducer 2 (Trop2), CD44, and CD49f preferentially formed spheres. In vivo implantation of sphere-forming cells and rUGSM regenerated tubular structures containing discreet basal and luminal layers. The TMPRSS-ERG fusion was absent in prostaspheres derived from fusion-positive tumor tissue, suggesting a survival/growth advantage of benign prostate epithelial cells.ConclusionHuman prostate sphere-forming cells self-renew, have tissue regeneration capability, and represent a subpopulation of basal cells.