Search

The Neupert effect refers to the strong correlation between the soft X-ray (SXR) light curve and the time-integrated hard X-rays (HXR) or microwave flux, which is frequently observed in solar flares. In this article, we therefore utilized the newly launched Hard X-ray Imager (HXI) on board the Advanced Space-based Solar Observatory to investigate the Neupert effect during solar flares. By checking the HXR light curves at 20-50 keV, a sample of 149 events that cover the flare impulsive phase were selected. Then, we performed a cross-correlation analysis between the HXR fluence (i.e., the time integral of the HXR flux) and the SXR 1-8 A flux measured by the Geostationary Operational Environmental Satellite. All the selected flares show high correlation coefficients (>0.90), which seem to be independent of the flare location and class. The HXR fluences tend to increase linearly with the SXR peak fluxes. Our observations indicate that all the selected flares obey the Neupert effect., Comment: 23 pages, 6 figures

Aims. We aim to investigate the molecular environment of the supernova remnant (SNR) G150.3+4.5, and explore its association with ambient molecular clouds (MCs). Methods. We present large-field CO (J=1-0) molecular line observations toward SNR G150.3+4.5, using the 13.7 m millimeter telescope of the Purple Mountain Observatory. The observations have an angular resolution of $\sim 55 ''$. We analyzed the spatial distribution of MCs in relation to the SNR shell detected in previous Urumqi $\lambda$ 6 cm radio observations and examined the CO spectra for kinematics information. Results. We find that MCs at the velocity range of [-14, -2] km s$^{-1}$ are spatially distributed along the radio shell of the SNR. Line broadening and asymmetries are observed in the CO spectra of the clouds. Moreover, we find that the molecular clouds around the shell have systematic velocity gradients in the position-velocity (PV) diagrams. Both morphology alignment and gas kinematics suggest that the SNR is associated with the ambient MCs at $\sim$ 740 pc. Based on the CO gas distance, the dimension and the age of the SNR is estimated to be 40 pc $\times$ 33 pc and 3.8 $ \times 10^4$ years, respectively. The very high energy emission of 1LHAASO J0428+5531 toward the SNR may originate from the interaction between the SNR and the surrounding MCs., Comment: 17 pages, 13 figures. Accepted by A&A 2024 March 28

Velocity fields of molecular clouds (MCs) can provide crucial information on the merger and split between clouds, as well as their internal kinematics and maintenance, energy injection and redistribution, even star formation within clouds. Using the CO spectral lines data from the Milky Way Imaging Scroll Painting (MWISP) survey, we measure the relative velocities along the line of sight ($\Delta$V$_{\rm LOS}$) between $^{13}$CO structures within $^{12}$CO MCs. Emphasizing MCs with double and triple $^{13}$CO structures, we find that approximately 70$\%$ of $\Delta$V$_{\rm LOS}$ values are less than $\sim$ 1 km s$^{-1}$, and roughly 10$\%$ of values exceed 2 km s$^{-1}$, with a maximum of $\sim$ 5 km s$^{-1}$. Additionally, we compare $\Delta$V$_{\rm LOS}$ with the internal velocity dispersion of $^{13}$CO structures ($\sigma_{\rm ^{13}CO,in}$) and find that about 40$\%$ of samples in either double or triple regime display distinct velocity discontinuities, i.e. the relative velocities between $^{13}$CO structures are larger than the internal linewidths of $^{13}$CO structures. Among these 40$\%$ samples in the triple regime, 33$\%$ exhibit signatures of combinations through the two-body motion, whereas the remaining 7$\%$ show features of configurations through the multiple-body motion. The $\Delta$V$_{\rm LOS}$ distributions for MCs with double and triple $^{13}$CO structures are similar, as well as their $\Delta$V$_{\rm LOS}$/$\sigma_{\rm ^{13}CO,in}$ distributions. This suggests that relative motions of $^{13}$CO structures within MCs are random and independent of cloud complexities and scales., Comment: 16 pages, 11 figures, accepted for publication in AJ

We perform a comprehensive CO study toward the Monoceros OB1 (Mon OB1) region based on the MWISP survey at an angular resolution of about $50''$. The high-sensitivity data, together with the high dynamic range, shows that molecular gas in the $\rm 8^{\circ}\times4^{\circ}$ region displays complicated hierarchical structures and various morphology (e.g., filamentary, cavity-like, shell-like, and other irregular structures). Based on Gaussian decomposition and clustering for $\mathrm{^{13}CO}$ data, a total of 263 $\mathrm{^{13}CO}$ structures are identified in the whole region, and 88\% of raw data flux is recovered. The dense gas with relatively high column density from the integrated CO emission is mainly concentrated in the region where multiple $\rm ^{13}CO$ structures are overlapped. Combining the results of 32 large $\mathrm{^{13}CO}$ structures with distances from Gaia DR3, we estimate an average distance of $\rm 729^{+45}_{-45}~pc$ for the GMC complex. The total mass of the GMC Complex traced by $\mathrm{^{12}CO}$, $\mathrm{^{13}CO}$, and $\mathrm{C^{18}O}$ are $1.1\times10^5~M_\odot$, $4.3\times10^4~M_\odot$, and $8.4\times10^3~M_\odot$, respectively. The dense gas fraction shows a clear difference between Mon OB1 GMC East (12.4\%) and Mon OB1 GMC West (3.3\%). Our results show that the dense gas environment is closely linked to the nearby star-forming regions. On the other hand, star-forming activities have a great influence on the physical properties of the surrounding molecular gas (e.g., greater velocity dispersion, higher temperatures, and more complex velocity structures, etc.). We also discuss the distribution/kinematics of molecular gas associated with nearby star-forming activities., Comment: 28 pages, 17 figures, accepted for publication on The Astrophysical Journal (ApJ). Comments are welcome

We study the physical properties and 3D distribution of molecular clouds (MCs) toward the Cygnus region using the MWISP CO survey and Gaia DR3 data. Based on Gaussian decomposition and clustering for $\rm ^{13}CO$ lines, over 70% of the fluxes are recovered. With the identification result of $\rm ^{13}CO$ structures, two models are designed to measure the distances of the molecular gas in velocity crowding regions. The distances of more than 200 large $\rm ^{13}CO$ structures are obtained toward the 150 square degree region. Additionally, tens of the identified MC structures coincide well with masers and/or intense mid-IR emission. We find multiple gas layers toward the region: (1) the extensive gas structures composing the Cygnus Rift from 700 pc to 1 kpc across the whole region; (2) the $\sim$ 1.3 kpc gas layer mainly in the Cygnus X South region; and (3) the 1.5 kpc dense filament at the Cygnus X North region and many cometary clouds shaped by Cygnus OB2. We also note that the spatial distribution of YSO candidates is generally consistent with the molecular gas structures. The total molecular mass of the Cygnus region is estimated to be $\sim 2.7\times10^{6}~M_{\odot}$ assuming an X-factor ratio $X_{\rm CO} = 2 \times 10^{20} \rm cm^{-2} (K\cdot km\cdot s^{-1})^{-1}$. The foreground Cygnus Rift contributes $\sim$25% of the molecular mass in the whole region. Our work presents a new 3D view of the MCs distribution toward the Cygnus X region, as well as the exact molecular gas mass distribution in the foreground Cygnus Rift., Comment: 57 pages, 26 figures, 4 tables, accepted for publication in the Astronomical Journal(AJ). Comments are welcome

The Spectrometer/Telescope for Imaging X-rays (STIX) on board Solar Orbiter (SolO) provides a unique opportunity to systematically perform stereoscopic X-ray observations of solar flares with current and upcoming X-ray missions at Earth. These observations will produce the first reliable measurements of hard X-ray (HXR) directivity in decades, providing a new diagnostic of the flare-accelerated electron angular distribution and helping to constrain the processes that accelerate electrons in flares. However, such observations must be compared to modelling, taking into account electron and X-ray transport effects and realistic plasma conditions, all of which can change the properties of the measured HXR directivity. Here, we show how HXR directivity, defined as the ratio of X-ray spectra at different spacecraft viewing angles, varies with different electron and flare properties (e.g., electron angular distribution, highest energy electrons, and magnetic configuration), and how modelling can be used to extract these typically unknown properties from the data. Lastly, we present a preliminary HXR directivity analysis of two flares, observed by the Fermi Gamma-ray Burst Monitor (GBM) and SolO/STIX, demonstrating the feasibility and challenges associated with such observations, and how HXR directivity can be extracted by comparison with the modelling presented here., Comment: Accepted for publication in ApJ (January 2024)

Most old supernova remnants (SNRs) in the Milky Way have not yet been identified. Considering their large potential number and the sufficient momentum-energy transfer to the interstellar medium (ISM), they are a key part of our understanding of the overall role of SNRs in the ISM. Here we report our discovery of an expanding molecular shell identified by CO line observations, namely G16.11-0.51. It covers a known SNR, specifically G16.0-0.5, and is larger in size, i.e. 0.56 deg over 0.20 deg. Based on its spatial and kinematic structures, weak nonthermal radio-continuum emission, and derived physical properties, we suggest that it is an old SNR. At a systemic velocity of +41.3 km s^-1, the best estimated kinematic distance of G16.11-0.51 is ~3.2 kpc, implying its radius of about 15.6 pc. The age of G16.11-0.51 is estimated to be greater than ~10^5 yr, and, in a dense molecular environment, it has formed dense and thin shell layers. The kinetic energy of the expanding molecular gas of G16.11-0.51 is about 6.4x10^49 erg, accounting for approximately six percent of the initial SN explosion energy. Although old SNRs have essentially become cold and hard to detect, our discovery suggests that they can be found by searching for CO line emissions., Comment: 10 pages, 6 figures, 1 table, in production in Astronomy&Astrophyics

Solar white-light flares (WLFs) are those accompanied by brightenings in the optical continuum or integrated light. The White-light Solar Telescope (WST), as an instrument of the Lyman-alpha Solar Telescope (LST) on the Advanced Space-based Solar Observatory (ASO-S), provides continuous solar full-disk images at 360 nm, which can be used to study WLFs. We analyze 205 major flares above M1.0 from October 2022 to May 2023 and identify 49 WLFs at 360 nm from WST observations, i.e. with an occurrence rate of 23.9%. The percentages of WLFs for M1 - M4 (31 out of 180), M5 - M9 (11 out of 18), and above X1 (7 for all) flares are 17.2%, 61.1%, and 100%, respectively, namely the larger the flares, the more likely they are WLFs at 360 nm. We further analyze 39 WLFs among the identified WLFs and investigate their properties such as white-light enhancement, duration, and brightening area. It is found that the relative enhancement of the white-light emission at 360 nm is mostly (>90%) less than 30% and the mean enhancement is 19.4%. The WLFs' duration at 360 nm is mostly (>80%) less than 20 minutes and its mean is 10.3 minutes. The brightening area at 360 nm is mostly (>75%) less than 500 arcsecond2 and the median value is 225. We find that there exist good correlations between the white-light enhancement/duration/area and the peak soft X-ray (SXR) flux of the flare, with correlation coefficients of 0.68, 0.58, and 0.80, respectively. In addition, the white-light emission in most WLFs peaks around the same time as the temporal derivative of SXR flux as well as the hard X-ray emission at 20 - 50 keV, indicative of Neupert effect. It is also found that the limb WLFs are more likely to have a greater enhancement, which is consistent with numerical simulations.

Diode effects are of great interest for both fundamental physics and modern technologies. Electrical diode effects (nonreciprocal transport) have been observed in Weyl systems. Optical diode effects arising from the Weyl fermions have been theoretically considered but not probed experimentally. Here, we report the observation of a nonlinear optical diode effect (NODE) in the magnetic Weyl semimetal CeAlSi, where the magnetization introduces a pronounced directionality in the nonlinear optical second-harmonic generation (SHG). We demonstrate a six-fold change of the measured SHG intensity between opposite propagation directions over a bandwidth exceeding 250 meV. Supported by density-functional theory, we establish the linearly dispersive bands emerging from Weyl nodes as the origin of this broadband effect. We further demonstrate current-induced magnetization switching and thus electrical control of the NODE. Our results advance ongoing research to identify novel nonlinear optical/transport phenomena in magnetic topological materials and further opens new pathways for the unidirectional manipulation of light. © The Author(s) 2024.

In the domain of causal inference research, the prevalent potential outcomes framework, notably the Rubin Causal Model (RCM), often overlooks individual interference and assumes independent treatment effects. This assumption, however, is frequently misaligned with the intricate realities of real-world scenarios, where interference is not merely a possibility but a common occurrence. Our research endeavors to address this discrepancy by focusing on the estimation of direct and spillover treatment effects under two assumptions: (1) network-based interference, where treatments on neighbors within connected networks affect one's outcomes, and (2) non-random treatment assignments influenced by confounders. To improve the efficiency of estimating potentially complex effects functions, we introduce an novel active learning approach: Active Learning in Causal Inference with Interference (ACI). This approach uses Gaussian process to flexibly model the direct and spillover treatment effects as a function of a continuous measure of neighbors' treatment assignment. The ACI framework sequentially identifies the experimental settings that demand further data. It further optimizes the treatment assignments under the network interference structure using genetic algorithms to achieve efficient learning outcome. By applying our method to simulation data and a Tencent game dataset, we demonstrate its feasibility in achieving accurate effects estimations with reduced data requirements. This ACI approach marks a significant advancement in the realm of data efficiency for causal inference, offering a robust and efficient alternative to traditional methodologies, particularly in scenarios characterized by complex interference patterns., Comment: conference paper

The evolving landscape of online multiplayer gaming presents unique challenges in assessing the causal impacts of game features. Traditional A/B testing methodologies fall short due to complex player interactions, leading to violations of fundamental assumptions like the Stable Unit Treatment Value Assumption (SUTVA). Unlike traditional social networks with stable and long-term connections, networks in online games are often dynamic and short-lived. Players are temporarily teamed up for the duration of a game, forming transient networks that dissolve once the game ends. This fleeting nature of interactions presents a new challenge compared with running experiments in a stable social network. This study introduces a novel framework for treatment effect estimation in online gaming environments, considering the dynamic and ephemeral network interference that occurs among players. We propose an innovative estimator tailored for scenarios where a completely randomized experimental design is implemented without explicit knowledge of network structures. Notably, our method facilitates post-hoc interference adjustment on experimental data, significantly reducing the complexities and costs associated with intricate experimental designs and randomization strategies. The proposed framework stands out for its ability to accommodate varying levels of interference, thereby yielding more accurate and robust estimations. Through comprehensive simulations set against a variety of interference scenarios, along with empirical validation using real-world data from a mobile gaming environment, we demonstrate the efficacy of our approach. This study represents a pioneering effort in exploring causal inference in user-randomized experiments impacted by dynamic network effects.

TLX is an orphan nuclear receptor that is expressed exclusively in vertebrate forebrains. Although TLX is known to be expressed in embryonic brains, the mechanism by which it influences neural development remains largely unknown. We show here that TLX is expressed specifically in periventricular neural stem cells in embryonic brains. Significant thinning of neocortex was observed in embryonic d 14.5 TLX-null brains with reduced nestin labeling and decreased cell proliferation in the germinal zone. Cell cycle analysis revealed both prolonged cell cycles and increased cell cycle exit in TLX-null embryonic brains. Increased expression of a cyclin-dependent kinase inhibitor p21 and decreased expression of cyclin D1 provide a molecular basis for the deficiency of cell cycle progression in embryonic brains of TLX-null mice. Furthermore, transient knockdown of TLX by in utero electroporation led to precocious cell cycle exit and differentiation of neural stem cells followed by outward migration. Together these results indicate that TLX plays an important role in neural development by regulating cell cycle progression and exit of neural stem cells in the developing brain.

We recently identified CD46 as a novel prostate cancer cell surface antigen that shows lineage independent expression in both adenocarcinoma and small cell neuroendocrine subtypes of metastatic castration resistant prostate cancer (mCRPC), discovered an internalizing human monoclonal antibody YS5 that binds to a tumor selective CD46 epitope, and developed a microtubule inhibitor-based antibody drug conjugate that is in a multi-center phase I trial for mCRPC (NCT03575819). Here we report the development of a novel CD46-targeted alpha therapy based on YS5. We conjugated 212Pb, an in vivo generator of alpha-emitting 212Bi and 212Po, to YS5 through the chelator TCMC to create the radioimmunoconjugate, 212Pb-TCMC-YS5. We characterized 212Pb-TCMC-YS5 in vitro and established a safe dose in vivo. We next studied therapeutic efficacy of a single dose of 212Pb-TCMC-YS5 using three prostate cancer small animal models: a subcutaneous mCRPC cell line-derived xenograft (CDX) model (subcu-CDX), an orthotopically grafted mCRPC CDX model (ortho-CDX), and a prostate cancer patient-derived xenograft model (PDX). In all three models, a single dose of 0.74 MBq (20 µCi) 212Pb-TCMC-YS5 was well tolerated and caused potent and sustained inhibition of established tumors, with significant increases of survival in treated animals. A lower dose (0.37 MBq or 10 µCi 212Pb-TCMC-YS5) was also studied on the PDX model, which also showed a significant effect on tumor growth inhibition and prolongation of animal survival. These results demonstrate that 212Pb-TCMC-YS5 has an excellent therapeutic window in preclinical models including PDXs, opening a direct path for clinical translation of this novel CD46-targeted alpha radioimmunotherapy for mCRPC treatment.

According to the structures traced by $^{13}$CO spectral lines within the $^{12}$CO molecular clouds (MCs), we investigate the contributions of their internal gas motions and relative motions to the total velocity dispersions of $^{12}$CO MCs. Our samples of 2851 $^{12}$CO MCs harbor a total of 9556 individual $^{13}$CO structures, among which 1848 MCs ($\sim$ 65$\%$) have one individual $^{13}$CO structure and the other 1003 MCs ($\sim$ 35$\%$) have multiple $^{13}$CO structures. We find that the contribution of the relative motion between $^{13}$CO structures ($\sigma_{\rm ^{13}CO, re}$) is larger than that from their internal gas motion ($\sigma_{\rm ^{13}CO, in}$) in $\sim$ 62$\%$ of 1003 MCs in the `multiple' regime. In addition, we find the $\sigma_{\rm ^{13}CO, re}$ tends to increase with the total velocity dispersion($\sigma_{\rm ^{12}CO, tot}$) in our samples, especially for the MCs having multiple $^{13}$CO structures. This result provides a manifestation of the macro-turbulent within MCs, which gradually becomes the dominant way to store the kinetic energy along with the development of MC scales., Comment: 15 pages, 13 figures, accepted for publication in ApJ

We compare the observational properties between $^{12}$CO, $^{13}$CO, and C$^{18}$O and summarize the observational parameters based on 7069 clouds sample from the Milky Way Imaging Scroll Painting (MWISP) CO survey in a section of the third Galactic quadrant. We find that the $^{13}$CO angular area ($A_{\rm ^{13}CO}$) generally increases with that of $^{12}$CO ($A_{\rm ^{12}CO}$), and the ratio of $A_{\rm ^{13}CO}$ to $A_{\rm ^{12}CO}$ is 0.38 by linear fitting. We find that the $^{12}$CO and $^{13}$CO flux are tightly correlated as $F_{\rm ^{13}CO}~=~0.17~ F_{\rm ^{12}CO}$ with both fluxes calculated within the $^{13}$CO-bright region. This indicates that the abundance $X_{\rm ^{13}CO}$ is a constant to be 6.5$^{+0.1}_{-0.5}$ $\times 10^{-7}$ for all samples under assumption of local thermodynamic equilibrium (LTE). Additionally, we observed that the X-factor is approximately constant in large sample molecular clouds. Similarly, we find $F_{\rm C^{18}O}~=~0.11~F_{\rm ^{13}CO}$ with both fluxes calculated within C$^{18}$O-bright region, which indicates that the abundance ratios ${X_{\rm ^{13}CO}/X_{\rm C^{18}O}}$ stays the same value 9.7$^{+0.6}_{-0.8}$ across the molecular clouds under LTE assumption. The linear relationships of $F_{\rm ^{12}CO}$ vs. $F_{\rm ^{13}CO}$ and $F_{\rm ^{13}CO}$ vs. $F_{\rm C^{18}O}$ hold not only for the $^{13}$CO-bright region or C$^{18}$O-bright region, but also for the entire molecular cloud scale with lower flux ratio. The abundance ratio ${X_{\rm ^{13}CO}/X_{\rm C^{18}O}}$ inside clouds shows a strong correlation with column density and temperature. This indicates that the ${X_{\rm ^{13}CO}/X_{\rm C^{18}O}}$ is dominated by a combination of chemical fractionation, selectively dissociation, and self-shielding effect inside clouds., Comment: 11 pages, 16 figures, 1 table, accepted by AJ

We present the results of an unbiased $^{12}$CO/$^{13}$CO/C$^{18}$O ($J$ = 1-0) survey in a portion of the third Galactic quadrant (TGQ): $l$ = [219.75, 229.75]$^\circ$ and $b$ = [-5.25, 5.25]$^\circ$. The high-resolution and high-sensitivity data sets help to unravel the distributions and physical properties of the molecular clouds (MCs) in the mapped area. In the LSR velocity range from -1 to 85 km/s, the molecular material successfully traces the Local, Perseus, and Outer arms. In the TGQ, the Outer arm appears to be more prominent than that in the second Galactic quadrant (SGQ), but the Perseus arm is not as conspicuous as that in the SGQ. A total of 1,502 $^{12}$CO, 570 $^{13}$CO, and 53 C$^{18}$O molecular structures are identified, spanning over $\sim2$ and $\sim6$ orders of magnitude in size and mass, respectively. Tight mass-radius correlations and virial parameter-mass anticorrelations are observable. Yet, it seems that no clear correlations between velocity dispersion and effective radius can be found over the full dynamic range. The vertical distribution of the MCs renders evident pictures of the Galactic warp and flare., Comment: 22 pages, 13 figures, 7 tables (with machine-readable versions), published in ApJS

We universally search for evidence of kinematic and spatial correlation of supernova remnant (SNR) and molecular cloud (MC) associations for nearly all SNRs in the coverage of the MWISP CO survey, i.e. 149 SNRs, 170 SNR candidates, and 18 pure pulsar wind nebulae (PWNe) in 1 deg < l < 230 deg and -5.5 deg < b < 5.5 deg. Based on high-quality and unbiased 12CO/13CO/C18O (J = 1--0) survey data, we apply automatic algorithms to identify broad lines and spatial correlations for molecular gas in each SNR region. The 91% of SNR-MC associations detected previously are identified in this paper by CO line emission. Overall, there could be as high as 80% of SNRs associated with MCs. The proportion of SNRs associated with MCs is high within the Galactic longitude less than ~50 deg. Kinematic distances of all SNRs that are associated with MCs are estimated based on systemic velocities of associated MCs. The radius of SNRs associated with MCs follows a lognormal distribution, which peaks at ~8.1 pc. The progenitor initial mass of these SNRs follows a power-law distribution with an index of ~-2.3 that is consistent with the Salpeter index of -2.35. We find that SNR-MC associations are mainly distributed in a thin disk along the Galactic plane, while a small amount distributed in a thick disk. With the height of these SNRs from the Galactic plane below ~45 pc, the distribution of the average radius relative to the height of them is roughly flat, and the average radius increases with the height when above ~45 pc., Comment: 77 pages, 20 figures, 4 tables (with machine-readable versions), accepted for publication in ApJS

The heating mechanisms of solar white-light flares remain unclear. We present an X1.0 white-light flare on 2022 October 2 (SOL2022-10-02T20:25) observed by the Chinese \ha\ Solar Explorer (CHASE) that provides two-dimensional spectra in the visible light for the full solar disk with a seeing-free condition. The flare shows a prominent enhancement of $\sim$40\% in the photospheric \fe\ line at 6569.2 \AA, and the nearby continuum also exhibits a maximum enhancement of $\sim$40\%. For the continuum near the \fe\ line at 6173 \AA\ from the Helioseismic and Magnetic Imager (HMI) on board the Solar Dynamics Observatory (SDO), it is enhanced up to $\sim$20\%. At the white-light kernels, the \fe\ line at 6569.2 \AA\ has a symmetric Gaussian profile that is still in absorption and the H$\alpha$ line at 6562.8 \AA\ displays a very broad emission profile with a central reversal plus a red or blue asymmetry. The white-light kernels are co-spatial with the microwave footpoint sources observed by the Expanded Owens Valley Solar Array (EOVSA) and the time profile of the white-light emission matches that of the hard X-ray emission above 30 keV from the Gamma-ray Burst Monitor (GBM) on Fermi. These facts indicate that the white-light emission is qualitatively related to a nonthermal electron beam. We also perform a radiative hydrodynamic simulation with the electron beam parameters constrained by the hard X-ray observations from Fermi/GBM. The result reveals that the white-light enhancement cannot be well explained by a pure electron-beam heating together with its induced radiative backwarming but may need additional heating sources such as \alfven\ waves., Comment: 15 pages, 5 figures, and 1 table

Weyl semimetal (WSM), a novel state of quantum matter, hosts Weyl fermions as emergent quasiparticles resulting from the breaking of either inversion or time-reversal symmetry. Magnetic WSMs that arise from broken time-reversal symmetry provide an exceptional platform to understand the interplay between magnetic order and Weyl physics, but only a few WSMs have been realized. Here, we identify CeAlSi as a new noncentrosymmetric magnetic WSM via angle-resolved photoemission spectroscopy (ARPES) and first-principles, density-functional theory based calculations. Our surface-sensitive vacuum ultraviolet ARPES data confirm the presence of surface Fermi arcs as the conclusive evidence for the existence of the Weyl semimetallic state in CeAlSi. We also observe bulk Weyl cones at the Fermi arc terminations in CeAlSi using bulk-sensitive soft-x-ray ARPES measurements. These results implicate CeAlSi as a unique platform for investigating exotic quantum phenomena resulting from the interaction of topology and magnetism.

In this paper we present the distribution of molecular gas in the Milky Way Galactic plane from $l$ = [59.75, 74.75]$^{\circ}$ and $b$ = [${-}$5.25, +5.25]$^{\circ}$, using the MWISP $^{12}$CO/$^{13}$CO/$\rm {C}^{18}{O}$ emission line data. The molecular gas in this region can be mainly attributed to the Local spur, Local arm, Perseus arm, and Outer arm. Statistics of the physical properties of the molecular gas in each arm, such as excitation temperature, optical depth, and column density, are presented. Using the DBSCAN algorithm, we identified 15 extremely distant molecular clouds with kinematic distances of 14.72$-$17.77 kpc and masses of 363$-$520 M$_{\odot}$, which we find could be part of the Outer Scutum-Centaurus (OSC) arm identified by \cite{2011ApJ...734L..24D} and \cite{2015ApJ...798L..27S}. It is also possible that, 12 of these 15 extremely distant molecular clouds constitute an independent structure between the Outer and the OSC arms or a spur. There exist two Gaussian components in the vertical distribution of the molecular gas in the Perseus spiral arm. These two Gaussian components correspond to two giant filaments parallel to the Galactic plane. We find an upward warping of the molecular gas in the Outer spiral arm with a displacement of around 270 pc with respect to the Galactic mid-plane., Comment: 33 pages, 19 figures

Evidence of efficient acceleration of cosmic rays in massive young stellar objects has been recently reported. Among these massive protostars, S255 NIRS 3 for which extreme flaring events associated with radio jets have been detected, is one of the best objects to test this hypothesis. We search for gamma-ray emission associated with this object in Fermi-LAT data and inspect the gas content in different molecular lines using the MWISP survey. A GeV source dubbed 4FGL J0613.1+1749c lies on top of the MYSO region, where two filamentary ~10 pc CO structures extend along the same direction of the sub-parsec radio jets. We investigate the spectrum, morphology, and light curve of the gamma-ray source and compare it with the theoretical emission expected from hadronic and leptonic populations accelerated in the radio jets. We argue that the gamma-ray source could be powered by particles accelerated in the S255 NIRS 3 jets, radiating via Bremsstrahlung or proton-proton interaction, and with a synchrotron component shinning in radio from primary or secondary electrons in the case of a leptonic or hadronic population., Comment: accepted for publication in Monthly Notices of the Royal Astronomical Society

Evidence of efficient acceleration of cosmic rays in massive young stellar objects has been recently reported. Among these massive protostars, S255 NIRS 3, for which extreme flaring events associated with radio jets have been detected, is one of the best objects to test this hypothesis. We search for gamma-ray emission associated with this object in Fermi-LAT data and inspect the gas content in different molecular lines using the MWISP survey. A GeV source dubbed 4FGL J0613.1+1749c lies on top of the MYSO region, where two filamentary ∼10 pc CO structures extend along the same direction of the subparsec radio jets. We investigate the spectrum, morphology, and light curve of the gamma-ray source and compare it with the theoretical emission expected from hadronic and leptonic populations accelerated in the radio jets. We argue that the gamma-ray source could be powered by particles accelerated in the S255 NIRS 3 jets, radiating via bremsstrahlung or proton–proton interaction, and with a synchrotron component shinning in radio from primary or secondary electrons in the case of a leptonic or hadronic population. © 2023 The Author(s) Published by Oxford University Press on behalf of Royal Astronomical Society.

Cellular-connected unmanned aerial vehicle (UAV) swarm is a promising solution for diverse applications, including cargo delivery and traffic control. However, it is still challenging to communicate with and control the UAV swarm with high reliability, low latency, and high energy efficiency. In this paper, we propose a two-phase command and control (C&C) transmission scheme in a cellular-connected UAV swarm network, where the ground base station (GBS) broadcasts the common C&C message in Phase I. In Phase II, the UAVs that have successfully decoded the C&C message will relay the message to the rest of UAVs via device-to-device (D2D) communications in either broadcast or unicast mode, under latency and energy constraints. To maximize the number of UAVs that receive the message successfully within the latency and energy constraints, we formulate the problem as a Constrained Markov Decision Process to find the optimal policy. To address this problem, we propose a decentralized constrained graph attention multi-agent Deep-Q-network (DCGA-MADQN) algorithm based on Lagrangian primal-dual policy optimization, where a PID-controller algorithm is utilized to update the Lagrange Multiplier. Simulation results show that our algorithm could maximize the number of UAVs that successfully receive the common C&C under energy constraints.

Ground-penetrating radar (GPR) is becoming a mainstream tool in planetary exploration, and one of the few in-situ planetary geophysical methods. There are currently three missions (Perseverance, Tianwen-1, Chang'E-4) with GPR-equipped rovers, and two future missions (Chang'E-7, ExoMars) that will include GPR in their scientific payload. The large number of GPR data, combined with the novel setup of the measurements, creates the need for new data processing and interpretation techniques to address the unique challenges of in-situ planetary radar. The current paper proposes an interpretation pipeline that starts with a novel stochastic hyperbola fitting that estimates the probability kernel density of the bulk permittivity at different depths. Subsequently, the bulk permittivity distribution is transformed via a novel probabilistic inversion to a 1-dimensional (1D) permittivity profile. The inverted 1D permittivity profile is then used as an input to a bespoke reverse-time migration (RTM) using the finite-difference time-domain (FDTD) method. RTM using FDTD does not assume a clinical homogeneous half-space; instead, it accounts for the expected layered structure of the investigated medium. Lastly, the migrated radargram is clustered in order to identify subsurface targets and distinguish them from the background medium. Each of the processing steps has never been reported in planetary radar; and together act as a complete processing toolbox tuned for planetary science. The suggested interpretation pipeline is validated numerically in a 1D case study with a complex layered structure and multiple subsurface targets. The proposed processing scheme is then applied to the GPR data from the Chang'E-4 mission at the Von Kármán crater, revealing a previously unseen layered structure and a complex distribution of rocks/boulders.

Decayless kink oscillations, which are nearly omnipresent in the solar corona, are believed to be driven by continuously operating energy supply. In this letter, we investigate an external continuous excitation of an apparent decayless oscillation during an X1.1 flare on June 20, 2023 (SOL2023-06-20T16:42).The decayless kink oscillation was identified in the coronal loop at extreme ultraviolet (EUV) wavelengths and the associated flare quasi-periodic pulsations (QPPs) were simultaneously observed in passbands of hard X-ray (HXR), microwave, and ultraviolet (UV) emissions. The kink oscillation is detected as a transverse oscillation of the coronal loop, which reveals five apparent cycles with an average period of about 130-10 s. The oscillation amplitude does not show any significantly decay, suggesting a decayless oscillation. At the same time, the solar flare occurs in the vicinity of the oscillating loop and exhibits five main pulses in HXR, microwave, and UV emissions, which could be regarded as flare QPPs. They have similar periods of about 100-130 s, which may indicate successive and repetitive energy releases during the flare impulsive phase. The peak of each loop oscillation cycle appears to follow the pulse of the QPPs, suggesting that the transverse oscillation is closely associated with flare QPPs. Our observations support the scenario where the repetitive energy released following flare QPPs could be invoked as external, continuously operating drivers of the apparent decayless kink oscillation., Comment: accepted by A&A

Large Language Models (LLMs) are trained and aligned to follow natural language instructions with only a handful of examples, and they are prompted as task-driven autonomous agents to adapt to various sources of execution environments. However, deploying agent LLMs in virtual reality (VR) has been challenging due to the lack of efficiency in online interactions and the complex manipulation categories in 3D environments. In this work, we propose Voice2Action, a framework that hierarchically analyzes customized voice signals and textual commands through action and entity extraction and divides the execution tasks into canonical interaction subsets in real-time with error prevention from environment feedback. Experiment results in an urban engineering VR environment with synthetic instruction data show that Voice2Action can perform more efficiently and accurately than approaches without optimizations.

Based on the MWISP survey, we study high-z CO emission toward the tangent points, in which the distances of the molecular clouds (MCs) are well determined. In the region of l=12-26 deg and |b|<5.1 deg, a total of 321 MCs with |z|> 110 pc are identified, of which nearly 30 extreme high-z MCs (EHMCs at |z|> 260 pc) are concentrated in a narrow region of R_GC=2.6-3.1 kpc. The EHMC concentrations, together with other high-z MCs at R_GC=2.3-2.6 kpc, constitute molecular crater-wall structures surrounding the edges of the HI voids that are physically associated with the Fermi bubbles. Intriguingly, some large high-z MCs, which lie in the crater-walls above and below the Galactic plane, show cometary structures with the head toward the plane, favouring the scenario that the entrained molecular gas moves with the multi-phase flows from the plane to the high-z regions. We suggest that the Milky Way nuclear wind has a significant impact on the Galactic gaseous disk. The powerful nuclear wind at ~3-6 Myr ago is likely responsible for the observational features, (1) the enhanced CO gas lying in the edges of the HI voids, (2) the deficiency of atomic and molecular gas within R_GC<3 kpc, (3) the possible connection between the EHMC concentrations and the 3-kpc arm, and (4) the elongated high-z MCs with the tail pointing away from the Galactic plane., Comment: 27 pages, 7 Figures, 1 Table. To appear in ApJ. Comments are welcome!

We conduct a detailed analysis of an M1.3 limb flare occurring on 2017 July 3, which have the X-ray observations recorded by multiple hard X-ray telescopes, including Hard X-ray Modulation Telescope (Insight-HXMT), Ramaty High Energy Solar Spectroscopic Imager (RHESSI), and The Fermi Gamma-ray Space Telescope (FERMI). Joint analysis has also used the EUV imaging data from the Atmospheric Imaging Assembly (AIA) aboard the Solar Dynamic Observatory. The hard X-ray spectral and imaging evolution suggest a lower corona source, and the non-thermal broken power law distribution has a rather low break energy $\sim$ 15 keV. The EUV imaging shows a rather stable plasma configuration before the hard X-ray peak phase, and accompanied by a filament eruption during the hard X-ray flare peak phase. Hard X-ray image reconstruction from RHESSI data only shows one foot point source. We also determined the DEM for the peak phase by SDO/AIA data. The integrated EM beyond 10 MK at foot point onset after the peak phase, while the $>$ 10 MK source around reconnection site began to fade. The evolution of EM and hard X-ray source supports lower corona plasma heating after non-thermal energy dissipation. The combination of hard X-ray spectra and images during the limb flare provides the understanding on the interchange of non-thermal and thermal energies, and relation between lower corona heating and the upper corona instability., Comment: 12 pages, 6 figures, Research in Astron. Astrophys. in press

Self-healing of creep-induced damage in newly designed 12Cr self-healing ferritic steels is studied. The damage healing is achieved by the segregation of supersaturated solute atoms at the free surface of the creep-induced cavities, and in this research, the healing phase is the W-riched Laves phase. Two kinds of self-healing steel with different precipitation driving forces of Laves phase are investigated, namely fast self-healing steel (FSHS) and slow self-healing steel (SSHS), in which the FSHS is designed to show the healing effect after 280 hours, while SSHS is designed to show healing effect after 27000 hours. Although both systems are self-healing systems, only FSHS is expected to show the self-healing phenomenon under the testing condition of this study, while SSHS not. Creep tests were performed on bone-shaped samples with constant stresses ranging from 100 to 260 MPa at 550 °C. The creep behavior is compared with traditional 9-12Cr ferritic steels, the relationship between the minimum creep rate and stress obeys Norton's power law, and the relationship between the lifetime and stress also obeys a power law. The total strain and stress exponents in power law of both SSHS and FSHS are relatively high compared to traditional 12Cr ferritic steel with similar grain size. The microstructure of the creep-failed samples, including the fracture surfaces, the uniformly-strained region (i.e., the stress-affected region), and the stress-free region are investigated with scanning electron microscopy (SEM). By comparing the feature of the stress-affected region and stress-free region exposed to the same thermal history, the effect of high-temperature exposure could be isolated from this. The effect of stress on the Laves phase precipitation behavior and the damage evolution could be understood more clearly. For both the SSHS and FSHS, a ductile and transgranular fracture mode is confirmed by analyzing the fracture surfaces. In the stress-affected region and stress-free, Aerospace Engineering

Battery cycle life prediction using early degradation data has many potential applications throughout the battery product life cycle. For that reason, various data-driven methods have been proposed for point prediction of battery cycle life with minimum knowledge of the battery degradation mechanisms. However, managing the rapidly increasing amounts of batteries at end-of-life with lower economic and technical risk requires prediction of cycle life with quantified uncertainty, which is still lacking. The interpretability (i.e., the reason for high prediction accuracy) of these advanced data-driven methods is also worthy of investigation. Here, a Quantile Regression Forest (QRF) model, having the advantage of not assuming any specific distribution of cycle life, is introduced to make cycle life range prediction with uncertainty quantified as the width of the prediction interval, in addition to point predictions with high accuracy. The hyperparameters of the QRF model are optimized with a proposed alpha-logistic-weighted criterion so that the coverage probabilities associated with the prediction intervals are calibrated. The interpretability of the final QRF model is explored with two global model-agnostic methods, namely permutation importance and partial dependence plot.

Internet of Things devices are widely adopted by the general population. People today are more connected than ever before. The widespread use and low-cost driven construction of these devices in a competitive marketplace render Internet-connected devices an easier and attractive target for malicious actors. This paper demonstrates non-invasive physical attacks against IoT devices in two case studies in a tutorial style format. The study focuses on demonstrating the: i)exploitation of debug interfaces, often left open after manufacture; and ii)the exploitation of exposed memory buses. We illustrate a person could commit such attacks with entry-level knowledge, inexpensive equipment, and limited time (in 8 to 25 minutes)., Comment: Published in IEEE PerCom Workshops 2022,978-1-6654-1647-4/22/$31.00 pp.643-648 Copyright 2022 IEEE

We look into the 2851 $^{12}$CO molecular clouds harboring $^{13}$CO structures to reveal the distribution of the projected angular separations and radial velocity separations between their internal $^{13}$CO structures. The projected angular separations are determined using the minimal spanning tree algorithm. We find that $\sim$ 50$\%$ of the angular separations fall in a narrow range of $\sim$ 3 - 7 arcmin with a median of $\sim$ 5 arcmin, and the corresponding radial velocity separations mainly range from $\sim$ 0.3 km s$^{-1}$ to 2.5 km s$^{-1}$. The mean and standard deviation of the angular separations of the internal $^{13}$CO structures within $^{12}$CO clouds appear to be universal, independent of the $^{12}$CO cloud angular areas and the counts of their internal $^{13}$CO structures. We also reveal a scaling relation between the $^{12}$CO cloud angular area and its harbored $^{13}$CO structure count. These results suggest there is a preferred angular separation between $^{13}$CO structures in these $^{12}$CO clouds, considering the distance effects. According to that, we propose an alternative picture for the assembly and destruction of molecular clouds: there is a fundamental separation for the internal structures of molecular clouds, the build-up and destruction of molecular clouds proceeds under this fundamental unit., Comment: 14 pages, 12 figures, accepted for publication in ApJ

We present wide-field and high-sensitivity CO(1-0) molecular line observations toward the Cassiopeia region, using the 13.7m millimeter telescope of the Purple Mountain Observatory (PMO). The CO observations reveal a large-scale highly filamentary molecular cloud within the Galactic region of 132\fdg0\,$\geq$\,$l$\,$\geq$\,122\fdg0 and -1\fdg0\,$\leq$\,$b$\,$\leq$\,3\fdg0 and the velocity range from approximately +1 to +4 km/s. The measured length of the large-scale filament, referred to as the Cassiopeia Filament, is about 390 pc. The observed properties of the Cassiopeia Filament, such as length, column density, and velocity gradient, are consistent with those synthetic large-scale filaments in the inter-arm regions. Based on its observed properties and location on the Galactic plane, we suggest that the Cassiopeia Filament is a spur of the Local arm, which is formed due to the galactic shear. The western end of the Cassiopeia Filament shows a giant arc-like molecular gas shell, which is extending in the velocity range from roughly -1 to +7 km/s. Finger-like structures, with systematic velocity gradients, are detected in the shell. The CO kinematics suggest that the large shell is expanding at a velocity of ~6.5 km/s. Both the shell and finger-like structures outline a giant bubble with a radius of ~16 pc, which is likely produced by stellar wind from the progenitor star of a supernova remnant. The observed spectral linewidths suggest that the whole Cassiopeia Filament was quiescent initially until its west part was blown by stellar wind and became supersonically turbulent., Comment: 46 pages, 19 figures, to be published by the AJ

Magnetic field extrapolation is a fundamental tool to reconstruct the three-dimensional magnetic field above the solar photosphere. However, the prevalently used force-free field model might not be applicable in the lower atmosphere with non-negligible plasma \b{eta}, where the crucial process of flux rope formation and evolution could happen. In this work, we perform extrapolation in active region (AR) 12158, based on an recently developed magnetohydrostatic (MHS) method which takes plasma forces into account. By comparing the results with those from the force-free field extrapolation methods, we find that the overall properties, which are characterized by the magnetic free energy and helicity, are roughly the same. The major differences lie in the magnetic configuration and the twist number of magnetic flux rope (MFR). Unlike previous works either obtained sheared arcades or one coherent flux rope, the MHS method derives two sets of MFR, which are highly twisted and slightly coupled. Specifically, the result in the present work is more comparable with the high-resolution observations from the chromosphere, through the transition region to the corona, such as the filament fibrils, pre-eruptive braiding characteristics and the eruptive double-J shaped hot channel. Overall, our work shows that the newly developed MHS method is more promising to reproduce the magnetic fine structures that can well match the observations at multiple layers, and future data-driven simulation based on such extrapolation will benefit in understanding the critical and precise dynamics of flux rope before eruption., Comment: The paper titled with 'Does the non-force-freeness matter for the extrapolation of solar magnetic field?' has been withdrawn, it is now replaced with a new paper titled with 'Magnetic field extrapolation in active region well comparable with observations in multiple layers'

Solar Ring (SOR) is a proposed space science mission to monitor and study the Sun and inner heliosphere from a full 360{\deg} perspective in the ecliptic plane. It will deploy three 120{\deg}-separated spacecraft on the 1-AU orbit. The first spacecraft, S1, locates 30{\deg} upstream of the Earth, the second, S2, 90{\deg} downstream, and the third, S3, completes the configuration. This design with necessary science instruments, e.g., the Doppler-velocity and vector magnetic field imager, wide-angle coronagraph, and in-situ instruments, will allow us to establish many unprecedented capabilities: (1) provide simultaneous Doppler-velocity observations of the whole solar surface to understand the deep interior, (2) provide vector magnetograms of the whole photosphere - the inner boundary of the solar atmosphere and heliosphere, (3) provide the information of the whole lifetime evolution of solar featured structures, and (4) provide the whole view of solar transients and space weather in the inner heliosphere. With these capabilities, Solar Ring mission aims to address outstanding questions about the origin of solar cycle, the origin of solar eruptions and the origin of extreme space weather events. The successful accomplishment of the mission will construct a panorama of the Sun and inner-heliosphere, and therefore advance our understanding of the star and the space environment that holds our life., Comment: 41 pages, 6 figures, 1 table, to be published in Advances in Space Research

We present the full data release of 12CO (3-2) High-Resolution Survey (COHRS), which has mapped the inner Galactic plane over the range of 9.5$^{\circ}$ $\le$ l $\le$ 62.3$^{\circ}$ and $|b| \le 0.5^{\circ}$. The COHRS has been carried out using the Heterodyne Array Receiver Program (HARP) on the 15 m James Clerk Maxwell Telescope (JCMT) in Hawaii. The released data are smoothed to have a spatial resolution of 16.6 arcsec and a velocity resolution of 0.635 km/s, achieving a mean root-mean-square of $\sim 0.6$ K on $T_\mathrm{A}^*$. The COHRS data are useful for investigating detailed three-dimensional structures of individual molecular clouds and large-scale structures such as spiral arms in the Galactic plane. Furthermore, data from other available public surveys of different CO isotopologues and transitions with similar angular resolutions to this survey, such as FUGIN, SEDIGISM, and CHIMPS/CHIMPS2, allow studying the physical properties of molecular clouds and comparing their states with each other. In this paper, we report further observations on R2 and improved data reduction since the original COHRS release. We discuss the characteristics of the COHRS data and present integrated-emission images and a position-velocity (PV) map of the region covered. The PV map shows a good match with the spiral-arm traces from the existing CO and HI surveys. We also obtain and compare integrated one-dimensional distributions of 12CO (1-0) and (3-2) and those of star-forming populations to each other., Comment: 29 pages, 13 figures, Accepted for publication in ApJS

We present a detailed analysis of a reflecting intensity perturbation in a large coronal loop that appeared as sloshing oscillation and lasted for at least one and a half periods. The perturbation is initiated by a microflare at one footpoint of the loop, propagates along the loop and is eventually reflected at the remote footpoint where significant brightenings are observed in all the AIA extreme-ultraviolet (EUV) channels. This unique observation provides us with the opportunity to better understand not only the thermal properties and damping mechanisms of the sloshing oscillation, but also the energy transfer at the remote footpoint. Based on differential emission measures (DEM) analysis and the technique of coronal seismology, we find that 1) the calculated local sound speed is consistent with the observed propagation speed of the perturbation during the oscillation, which is suggestive of a slow magnetoacoustic wave; 2) thermal conduction is the major damping mechanism of the wave but additional damping mechanism such as anomalous enhancement of compressive viscosity or wave leakage is also required to account for the rapid decay of the observed waves; 3) the wave produced a nanoflare at the remote footpoint, with a peak thermal energy of $\thicksim10^{24}-10^{25}$ erg. This work provides a consistent picture of the magnetoacoustic wave propagation and reflection in a coronal loop, and reports the first solid evidence of a wave-induced nanoflare. The results reveal new clues for further simulation studies and may help solving the coronal heating problem., Comment: 13pages, 5 figures; Accepted by ApJL

We present observations of $J$=1-0 transition lines of ${ }^{12} \mathrm{CO}$, ${ }^{13} \mathrm{CO}$, and $\mathrm{C}^{18} \mathrm{O}$ towards the Galactic region of $153.60^{\circ} \leqslant l \leqslant 156.50^{\circ}$ and $1.85^{\circ} \leqslant b \leqslant 3.50^{\circ}$, using the Purple Mountain Observatory (PMO) 13.7 m millimeter telescope. Based on the \tht data, one main filament and five sub-filaments are found together as a network structure in the velocity interval of $[-42.5, -30.0] \,\mathrm{km} \mathrm{\,s}^{-1}$. The kinematic distance of this molecular cloud (MC) is estimated to be $\sim4.5 \mathrm{\,kpc}$. The median length, width, excitation temperature, line mass of these filaments are $\sim49 \mathrm{\,pc}$, $\sim2.9 \mathrm{\,pc}$, $\sim8.9 \mathrm{\,K}$, and $\sim39 \,M_{\odot} \mathrm{pc}^{-1}$, respectively. The velocity structures along these filaments exhibit oscillatory patterns, which are likely caused by the fragmentation or accretion process along these filaments. The maximum accretion rate is estimated to be as high as $\sim700 \,M_{\odot} \mathrm{pc}^{-1}$. A total of $\sim162$ \tht clumps and $\sim 103$ young stellar objects (YSOs) are identified in this region. Most of the clumps are in gravitationally bound states. Three \hii regions (G154.359+2.606, SH2-211, SH2-212) are found to be located in the apexes of the filaments. Intense star forming activities are found along the entire filamentary cloud. The observed results may help us to better understand the link between filaments and massive star formation., Comment: 45 pages, 23 figures, accepted by ApJ

We report on the near-infrared polarimetric observations of G11.11-0.12 (hereafter G11) obtained with SIRPOL on the 1.4 m IRSF telescope. The starlight polarisation of the background stars reveals the on-sky component of magnetic fields in G11, and these are consistent with the field orientation observed from polarised dust emission at $850\,\mu$m. The magnetic fields in G11 are perpendicular to the filament, and are independent of the filament's orientation relative to the Galactic plane. The field strength in the envelope of G11 is in the range $50-100\,\mu$G, derived from two methods. The analyses of the magnetic fields and gas velocity dispersion indicate that the envelope of G11 is supersonic but sub-Alfv{\'e}nic. The critical mass-to-flux ratio in the envelope of G11 is close to 1 and increases to $\gtrsim 1$ on the spine of G11. The relative weights on the importance of magnetic fields, turbulence and gravity indicate that gravity dominates the dynamical state of G11, but with significant contribution from magnetic fields. The field strength, $|\mathbf{B}|$, increases slower than the gas density, $n$, from the envelope to the spine of G11, characterized by $|\mathbf{B}|\propto n^{0.3}$. The observed strength and orientation of magnetic fields in G11 imply that supersonic and sub-Alfv{\'e}nic gas flow is channelled by the strong magnetic fields and is assembled into filaments perpendicular to the magnetic fields. The formation of low-mass stars is enhanced in the filaments with high column density, in agreement with the excess of low-mass protostars detected in the densest regions of G11., Comment: accepted for publication in Monthly Notices of the Royal Astronomical Society Main Journal; 16 pages, 10 figures

After the morphological classification of the 18,190 $^{12}$CO molecular clouds, we further investigate the properties of their internal molecular gas structures traced by the $^{13}$CO($J=$ 1$-$0) line emissions. Using three different methods to extract the $^{13}$CO gas structures within each $^{12}$CO cloud, we find that $\sim$ 15$\%$ of $^{12}$CO clouds (2851) have $^{13}$CO gas structures and these $^{12}$CO clouds contribute about 93$\%$ of the total integrated flux of $^{12}$CO emission. In each of 2851 $^{12}$CO clouds with $^{13}$CO gas structures, the $^{13}$CO emission area generally does not exceed 70$\%$ of the $^{12}$CO emission area, and the $^{13}$CO integrated flux does not exceed 20$\%$ of the $^{12}$CO integrated flux. We reveal a strong correlation between the velocity-integrated intensities of $^{12}$CO lines and those of $^{13}$CO lines in both $^{12}$CO and $^{13}$CO emission regions. This indicates the H$_{2}$ column densities of molecular clouds are crucial for the $^{13}$CO lines emission. After linking the $^{13}$CO structure detection rates of the 18,190 $^{12}$CO molecular clouds to their morphologies, i.e. nonfilaments and filaments, we find that the $^{13}$CO gas structures are primarily detected in the $^{12}$CO clouds with filamentary morphologies. Moreover, these filaments tend to harbor more than one $^{13}$CO structure. That demonstrates filaments not only have larger spatial scales, but also have more molecular gas structures traced by $^{13}$CO lines, i.e. the local gas density enhancements. Our results favor the turbulent compression scenario for filament formation, in which dynamical compression of turbulent flows induces the local density enhancements. The nonfilaments tend to be in the low-pressure and quiescent turbulent environments of the diffuse interstellar medium., Comment: 21 pages, 14 Figures; Appendix (17 pages, 19 Figures); Accepted for publication in the journal ApJS

In this work, we investigate the observational and algorithmic effects on molecular cloud samples identified from position-position-velocity (PPV) space. By smoothing and cutting off the high quality data of the Milky Way Imaging Scroll Painting (MWISP) survey, we extract various molecular cloud samples from those altered data with the DBSCAN (density-based spatial clustering of applications with noise) algorithm. Those molecular cloud samples are subsequently used to gauge the significance of sensitivity, angular/velocity resolution, and DBSCAN parameters. Two additional surveys, the FCRAO Outer Galaxy Survey (OGS) and the CfA-Chile 1.2 m complete CO (CfA-Chile) survey, are used to verify the MWISP results. We found that molecular cloud catalogs are not unique and the boundary and therefore the number shows strong variation with angular resolution and sensitivity. At low angular resolution (large beam sizes), molecular clouds merge together in PPV space, while low sensitivity (high cutoffs) misses small faint molecular clouds and takes bright parts of large molecular clouds as single ones. At high angular resolution and sensitivity, giant molecular clouds (GMCs) are resolved into individual clouds, and their diffuse components are also revealed. Consequently, GMCs are more appropriately interpreted as clusters or aggregates of molecular clouds, i.e., GMCs represent molecular cloud samples themselves., Comment: 25 pages, 21 figures. Accepted for publication in AJ

Based on the MWISP survey, we study high-z CO emission toward the tangent points, in which the distances of the molecular clouds (MCs) are well determined. In the region of l=12-26 deg and |b|<5.1 deg, a total of 321 MCs with |z|> 110 pc are identified, of which nearly 30 extreme high-z MCs (EHMCs at |z|> 260 pc) are concentrated in a narrow region of R_GC=2.6-3.1 kpc. The EHMC concentrations, together with other high-z MCs at R_GC=2.3-2.6 kpc, constitute molecular crater-wall structures surrounding the edges of the HI voids that are physically associated with the Fermi bubbles. Intriguingly, some large high-z MCs, which lie in the crater walls above and below the Galactic plane, show cometary structures with the head toward the plane, favouring the scenario that the entrained molecular gas moves with the multi-phase flows from the plane to the high-z regions. We suggest that the Milky Way nuclear wind has a significant impact on the Galactic gaseous disk. The powerful nuclear wind at ~3-6 Myr ago is likely responsible for the observational features, (1) the enhanced CO gas lying in the edges of the HI voids, (2) the deficiency of atomic and molecular gas within R_GC<3 kpc, (3) the possible connection between the EHMC concentrations and the 3-kpc arm, and (4) the elongated high-z MCs with the tail pointing away from the Galactic plane., Comment: 27 pages, 7 Figures, 1 Table, typo corrected

We conduct a detailed analysis of an M1.3 limb flare occurring on 2017 July 3, which have the X-ray observations recorded by multiple hard X-ray telescopes, including Hard X-ray Modulation Telescope (Insight-HXMT), Ramaty High Energy Solar Spectroscopic Imager (RHESSI), and The Fermi Gamma-ray Space Telescope (FERMI). Joint analysis has also used the EUV imaging data from the Atmospheric Imaging Assembly (AIA) aboard the Solar Dynamic Observatory. The hard X-ray spectral and imaging evolution suggest a lower corona source, and the non-thermal broken power law distribution has a rather low break energy $\sim$ 15 keV. The EUV imaging shows a rather stable plasma configuration before the hard X-ray peak phase, and accompanied by a filament eruption during the hard X-ray flare peak phase. Hard X-ray image reconstruction from RHESSI data only shows one foot point source. We also determined the DEM for the peak phase by SDO/AIA data. The integrated EM beyond 10 MK at foot point onset after the peak phase, while the $>$ 10 MK source around reconnection site began to fade. The evolution of EM and hard X-ray source supports lower corona plasma heating after non-thermal energy dissipation. The combination of hard X-ray spectra and images during the limb flare provides the understanding on the interchange of non-thermal and thermal energies, and relation between lower corona heating and the upper corona instability., Comment: 12 pages, 6 figures, Research in Astron. Astrophys. in press

An energy-efficient triple-column extractive distillation process is developed for recovering tetrahydrofuran and ethyl acetate from industrial effluent. The process development follows a rigorous hierarchical design procedure that involves entrainer design, thermodynamic analysis, process design and optimization, and heat integration. The computer-aided molecular design method is firstly used to find promising entrainer candidates and the best one is determined via rigorous thermodynamic analysis. Subsequently, the direct and indirect triple-column extractive distillation processes are proposed in the conceptual design step. These two extractive distillation processes are then optimized by employing an improved genetic algorithm. Finally, heat integration is performed to further reduce the process energy consumption. The results indicate that the indirect extractive distillation process with heat integration shows the highest performance in terms of the process economics.

Self-healing of creep-induced damage in newly designed 12Cr self-healing ferritic steels is studied. The damage healing is achieved by the segregation of supersaturated solute atoms at the free surface of the creep-induced cavities, and in this research, the healing phase is the W-riched Laves phase. Two kinds of self-healing steel with different precipitation driving forces of Laves phase are investigated, namely fast self-healing steel (FSHS) and slow self-healing steel (SSHS), in which the FSHS is designed to show the healing effect after 280 hours, while SSHS is designed to show healing effect after 27000 hours. Although both systems are self-healing systems, only FSHS is expected to show the self-healing phenomenon under the testing condition of this study, while SSHS not. Creep tests were performed on bone-shaped samples with constant stresses ranging from 100 to 260 MPa at 550 °C. The creep behavior is compared with traditional 9-12Cr ferritic steels, the relationship between the minimum creep rate and stress obeys Norton's power law, and the relationship between the lifetime and stress also obeys a power law. The total strain and stress exponents in power law of both SSHS and FSHS are relatively high compared to traditional 12Cr ferritic steel with similar grain size. The microstructure of the creep-failed samples, including the fracture surfaces, the uniformly-strained region (i.e., the stress-affected region), and the stress-free region are investigated with scanning electron microscopy (SEM). By comparing the feature of the stress-affected region and stress-free region exposed to the same thermal history, the effect of high-temperature exposure could be isolated from this. The effect of stress on the Laves phase precipitation behavior and the damage evolution could be understood more clearly. For both the SSHS and FSHS, a ductile and transgranular fracture mode is confirmed by analyzing the fracture surfaces. In the stress-affected region and stress-free, Aerospace Engineering

Identification of tumor-specific cell surface antigens has proven challenging, as the vast majority of tumor-associated antigens are also expressed in normal tissues. In mesothelioma, we identified a highly specific tumor cell surface antigen that can be targeted for therapy development. Mesothelioma is caused by malignant transformation of the mesothelium, is incurable, and can be categorized into three histologic subtypes: epithelioid, biphasic, and sarcomatoid. To identity novel mesothelioma cell surface antigens with broad subtype coverage and high tissue specificity, we have previously selected phage antibody display libraries on live mesothelioma cells and tissues following counterselection on normal cells and identified a panel of human antibodies that bind all subtypes of mesothelioma, but not normal mesothelium. One of the antibodies, M25, showed high specificity against an antigen we identify here as ALPPL2. IHC on normal human tissues found that ALPPL2 is expressed only on placental trophoblasts, but not on any other normal tissues. This significant tissue specificity and broad tumor type coverage suggest that ALPPL2 could be an excellent cell surface target for therapeutic development against mesothelioma. To evaluate therapeutic potential of ALPPL2 targeting, an ALPPL2-targeted antibody-drug conjugate was developed and demonstrated potent and specific tumor killing in vitro and in vivo against both epithelioid and sarcomatoid mesothelioma. Thus, ALPPL2 belongs to a rare class of cell surface antigens classified as truly tumor specific and is well suited for therapy development against ALPPL2-expressing tumors. SIGNIFICANCE: These findings identify ALPP2 as a true tumor-specific cell surface antigen whose tissue specificity enables the development of novel therapies.

Direct oxidation of methane into value-added C1 oxygenated products, such as methanol, is essential and remains a significant challenge in the field of catalysis. In this work, we have prepared Fe/ZSM-5 materials via three different methods and investigated the influence of various preparation methods on the composition and catalytic performance of Fe/ZSM-5 for the low-temperature oxidation of methane. Through a combination of scanning transmission electron microscopy, ultraviolet-visible diffuse reflectance and 57Fe Mössbauer spectroscopy, we have found that the highest proportion of monomeric Fe species of 71 % could be achieved in the ZSM-5 zeolite by the solid-state ion-exchange method, affording an excellent C1 oxygenates yield of 120 mol/molFe with a C1 oxygenates selectivity of 96 % at 50 °C for 30 min in the aqueous solution of H2O2.

Diet is a major factor that shapes the gut microbiome1, but the consequences of diet-induced changes in the microbiome for host pathophysiology remain poorly understood. We conducted a randomized human intervention study using a very-low-calorie diet (NCT01105143). Although metabolic health was improved, severe calorie restriction led to a decrease in bacterial abundance and restructuring of the gut microbiome. Transplantation of post-diet microbiota to mice decreased their body weight and adiposity relative to mice that received pre-diet microbiota. Weight loss was associated with impaired nutrient absorption and enrichment in Clostridioides difficile, which was consistent with a decrease in bile acids and was sufficient to replicate metabolic phenotypes in mice in a toxin-dependent manner. These results emphasize the importance of diet-microbiome interactions in modulating host energy balance and the need to understand the role of diet in the interplay between pathogenic and beneficial symbionts.

We present the analysis of Fermi Large Area Telecope (LAT) data of the gamma-ray emission in the vicinity of a radio supernova remnant (SNR), G045.7$-$00.4. To study the origin of the gamma-ray emission, we also make use of the CO survey data of Milky Way Imaging Scroll Painting to study the massive molecular gas complex that surrounds the SNR. The whole size of the GeV emission is significantly larger than that of the radio morphology. Above 3 GeV, the GeV emission is resolved into two sources: one is spatially consistent with the position of the SNR with a size comparable to that of the radio emission, and the other is located outside of the western boundary of the SNR and spatially coincident with the densest region of the surrounding molecular cloud. We suggest that the GeV emission of the western source may arise from cosmic rays (CRs) which have escaped the SNR and illuminated the surrounding molecular cloud. We find that the gamma-ray spectra of the western source can be consistently explained by this scenario with a total energy of $\sim 10^{50}{\rm erg}$ in escaping CRs assuming the escape is isotropic., Comment: 11 pages, 7 figures and 1 table -Accepted for publication in ApJ

We present wide-field multi-wavelength observations of $\gamma$ Cassiopeiae (or $\gamma$~Cas for short) in order to study its feedback toward the interstellar environment. A large expanding cavity is discovered toward $\gamma$~Cas in the neutral hydrogen (HI) images at a systemic velocity of about -10 km/s. The measured dimension of the cavity is roughly 2.0 deg $\times$ 1.4 deg (or 6.0 pc $\times$ 4.2 pc at a distance of 168 pc), while the expansion velocity is about 5.0$\pm$0.5 km/s. The CO observations reveal systematic velocity gradients in IC63 (about 20 km/s/pc) and IC59 (about 30 km/s/pc), two cometary globules illuminated by $\gamma$~Cas, proving fast acceleration of the globules under stellar radiation pressure. The gas kinematics indicate that the cavity is opened by strong stellar wind, which has high potential to lead to the peculiar X-ray emission observed in $\gamma$~Cas. Our result favors a recent new scenario that emphasizes the roles of stellar wind and binarity in the X-ray emission of the $\gamma$~Cas stars., Comment: 21 pages, 7 figures, to be published by the ApJ