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2,260 results on '"Straumann, A."'

1. Justice and republicanism

Author: Lovett, Frank, Sellers, Mortimer, Lovett, F ( Frank ), Sellers, M ( Mortimer ), Straumann, Benjamin; https://orcid.org/0000-0003-4115-7496, Lovett, Frank, Sellers, Mortimer, Lovett, F ( Frank ), Sellers, M ( Mortimer ), and Straumann, Benjamin; https://orcid.org/0000-0003-4115-7496
Abstract: This chapter discusses the conception of justice put forward by the Roman thinker Marcus Tullius Cicero (106–43 BCE). Cicero wrote in the context of the collapse of the Roman republic, the largest and longest-lived republic hitherto in existence, and developed a political theory that put justice and legality front and center. Cicero’s jural or constitutional republicanism differs interestingly from both his eudaemonist Greek predecessors and present-day republicans. His theory of justice formulated a principle of popular sovereignty, albeit one limited by natural law; it gave fundamental importance to a set of equal rights, some of which were seen as pre-political; and it sketched a view of the common good understood as what accrues to people living under a system of public law (ius). This yields a jural theory of the state (res publica), a view that accords justice priority even before liberty, but justice here is not understood as personal virtue, but as something that necessarily has to be expressed in legal form, as rules. These rules survive Cicero’s scepticism: we can know them with a high degree of certainty, unlike conceptions of the highest good (summum bonum). The chapter closes by discussing how Cicero’s Roman theory of justice differs from some of the views put forward by some of today’s republicans.
Published: 2024

2. The importance of considering competing risks in recurrence analysis of intracranial meningioma

Author: Mirian, Christian, Jensen, Lasse Rehné, Juratli, Tareq A., Maier, Andrea Daniela, Torp, Sverre H., Shih, Helen A., Morshed, Ramin A., Young, Jacob S., Magill, Stephen T., Bertero, Luca, Stummer, Walter, Spille, Dorothee Cäcilia, Brokinkel, Benjamin, Oya, Soichi, Miyawaki, Satoru, Saito, Nobuhito, Proescholdt, Martin, Kuroi, Yasuhiro, Gousias, Konstantinos, Simon, Matthias, Moliterno, Jennifer, Prat-Acin, Ricardo, Goutagny, Stéphane, Prabhu, Vikram C., Tsiang, John T., Wach, Johannes, Güresir, Erdem, Yamamoto, Junkoh, Kim, Young Zoon, Lee, Joo Ho, Koshy, Matthew, Perumal, Karthikeyan, Baskaya, Mustafa K., Cannon, Donald M., Shrieve, Dennis C., Suh, Chang Ok, Chang, Jong Hee, Kamenova, Maria, Straumann, Sven, Soleman, Jehuda, Eyüpoglu, Ilker Y., Catalan, Tony, Lui, Austin, Theodosopoulos, Philip V., McDermott, Michael W., Wang, Fang, Guo, Fuyou, Góes, Pedro, de Paiva Neto, Manoel Antonio, Jamshidi, Aria, Komotar, Ricardo, Ivan, Michael, Luther, Evan, Souhami, Luis, Guiot, Marie Christine, Csonka, Tamás, Endo, Toshiki, Barrett, Olivia Claire, Jensen, Randy, Gupta, Tejpal, Patel, Akash J., Klisch, Tiemo J., Kim, Jun Won, Maiuri, Francesco, Barresi, Valeria, Tabernero, María Dolores, Skyrman, Simon, Broechner, Anders, Bach, Mathias Jacobsen, Law, Ian, Scheie, David, Kristensen, Bjarne Winther, Munch, Tina Nørgaard, Meling, Torstein, Fugleholm, Kåre, Blanche, Paul, Mathiesen, Tiit, Mirian, Christian, Jensen, Lasse Rehné, Juratli, Tareq A., Maier, Andrea Daniela, Torp, Sverre H., Shih, Helen A., Morshed, Ramin A., Young, Jacob S., Magill, Stephen T., Bertero, Luca, Stummer, Walter, Spille, Dorothee Cäcilia, Brokinkel, Benjamin, Oya, Soichi, Miyawaki, Satoru, Saito, Nobuhito, Proescholdt, Martin, Kuroi, Yasuhiro, Gousias, Konstantinos, Simon, Matthias, Moliterno, Jennifer, Prat-Acin, Ricardo, Goutagny, Stéphane, Prabhu, Vikram C., Tsiang, John T., Wach, Johannes, Güresir, Erdem, Yamamoto, Junkoh, Kim, Young Zoon, Lee, Joo Ho, Koshy, Matthew, Perumal, Karthikeyan, Baskaya, Mustafa K., Cannon, Donald M., Shrieve, Dennis C., Suh, Chang Ok, Chang, Jong Hee, Kamenova, Maria, Straumann, Sven, Soleman, Jehuda, Eyüpoglu, Ilker Y., Catalan, Tony, Lui, Austin, Theodosopoulos, Philip V., McDermott, Michael W., Wang, Fang, Guo, Fuyou, Góes, Pedro, de Paiva Neto, Manoel Antonio, Jamshidi, Aria, Komotar, Ricardo, Ivan, Michael, Luther, Evan, Souhami, Luis, Guiot, Marie Christine, Csonka, Tamás, Endo, Toshiki, Barrett, Olivia Claire, Jensen, Randy, Gupta, Tejpal, Patel, Akash J., Klisch, Tiemo J., Kim, Jun Won, Maiuri, Francesco, Barresi, Valeria, Tabernero, María Dolores, Skyrman, Simon, Broechner, Anders, Bach, Mathias Jacobsen, Law, Ian, Scheie, David, Kristensen, Bjarne Winther, Munch, Tina Nørgaard, Meling, Torstein, Fugleholm, Kåre, Blanche, Paul, and Mathiesen, Tiit
Abstract: Background The risk of recurrence is overestimated by the Kaplan–Meier method when competing events, such as death without recurrence, are present. Such overestimation can be avoided by using the Aalen-Johansen method, which is a direct extension of Kaplan–Meier that accounts for competing events. Meningiomas commonly occur in older individuals and have slow-growing properties, thereby warranting competing risk analysis. The extent to which competing events are considered in meningioma literature is unknown, and the consequences of using incorrect methodologies in meningioma recurrence risk analysis have not been investigated. Methods We surveyed articles indexed on PubMed since 2020 to assess the usage of competing risk analysis in recent meningioma literature. To compare recurrence risk estimates obtained through Kaplan–Meier and Aalen-Johansen methods, we applied our international database comprising ~ 8,000 patients with a primary meningioma collected from 42 institutions. Results Of 513 articles, 169 were eligible for full-text screening. There were 6,537 eligible cases from our PERNS database. The discrepancy between the results obtained by Kaplan–Meier and Aalen-Johansen was negligible among low-grade lesions and younger individuals. The discrepancy increased substantially in the patient groups associated with higher rates of competing events (older patients with high-grade lesions). Conclusion The importance of considering competing events in recurrence risk analysis is poorly recognized as only 6% of the studies we surveyed employed Aalen-Johansen analyses. Consequently, most of the previous literature has overestimated the risk of recurrence. The overestimation was negligible for studies involving low-grade lesions in younger individuals; however, overestimation might have been substantial for studies on high-grade lesions., Background: The risk of recurrence is overestimated by the Kaplan–Meier method when competing events, such as death without recurrence, are present. Such overestimation can be avoided by using the Aalen-Johansen method, which is a direct extension of Kaplan–Meier that accounts for competing events. Meningiomas commonly occur in older individuals and have slow-growing properties, thereby warranting competing risk analysis. The extent to which competing events are considered in meningioma literature is unknown, and the consequences of using incorrect methodologies in meningioma recurrence risk analysis have not been investigated. Methods: We surveyed articles indexed on PubMed since 2020 to assess the usage of competing risk analysis in recent meningioma literature. To compare recurrence risk estimates obtained through Kaplan–Meier and Aalen-Johansen methods, we applied our international database comprising ~ 8,000 patients with a primary meningioma collected from 42 institutions. Results: Of 513 articles, 169 were eligible for full-text screening. There were 6,537 eligible cases from our PERNS database. The discrepancy between the results obtained by Kaplan–Meier and Aalen-Johansen was negligible among low-grade lesions and younger individuals. The discrepancy increased substantially in the patient groups associated with higher rates of competing events (older patients with high-grade lesions). Conclusion: The importance of considering competing events in recurrence risk analysis is poorly recognized as only 6% of the studies we surveyed employed Aalen-Johansen analyses. Consequently, most of the previous literature has overestimated the risk of recurrence. The overestimation was negligible for studies involving low-grade lesions in younger individuals; however, overestimation might have been substantial for studies on high-grade lesions.
Published: 2024

3. The importance of considering competing risks in recurrence analysis of intracranial meningioma

Author: Mirian, Christian, Jensen, Lasse Rehné, Juratli, Tareq A., Maier, Andrea Daniela, Torp, Sverre H., Shih, Helen A., Morshed, Ramin A., Young, Jacob S., Magill, Stephen T., Bertero, Luca, Stummer, Walter, Spille, Dorothee Cäcilia, Brokinkel, Benjamin, Oya, Soichi, Miyawaki, Satoru, Saito, Nobuhito, Proescholdt, Martin, Kuroi, Yasuhiro, Gousias, Konstantinos, Simon, Matthias, Moliterno, Jennifer, Prat-Acin, Ricardo, Goutagny, Stéphane, Prabhu, Vikram C., Tsiang, John T., Wach, Johannes, Güresir, Erdem, Yamamoto, Junkoh, Kim, Young Zoon, Lee, Joo Ho, Koshy, Matthew, Perumal, Karthikeyan, Baskaya, Mustafa K., Cannon, Donald M., Shrieve, Dennis C., Suh, Chang Ok, Chang, Jong Hee, Kamenova, Maria, Straumann, Sven, Soleman, Jehuda, Eyüpoglu, Ilker Y., Catalan, Tony, Lui, Austin, Theodosopoulos, Philip V., McDermott, Michael W., Wang, Fang, Guo, Fuyou, Góes, Pedro, de Paiva Neto, Manoel Antonio, Jamshidi, Aria, Komotar, Ricardo, Ivan, Michael, Luther, Evan, Souhami, Luis, Guiot, Marie Christine, Csonka, Tamás, Endo, Toshiki, Barrett, Olivia Claire, Jensen, Randy, Gupta, Tejpal, Patel, Akash J., Klisch, Tiemo J., Kim, Jun Won, Maiuri, Francesco, Barresi, Valeria, Tabernero, María Dolores, Skyrman, Simon, Broechner, Anders, Bach, Mathias Jacobsen, Law, Ian, Scheie, David, Kristensen, Bjarne Winther, Munch, Tina Nørgaard, Meling, Torstein, Fugleholm, Kåre, Blanche, Paul, Mathiesen, Tiit, Mirian, Christian, Jensen, Lasse Rehné, Juratli, Tareq A., Maier, Andrea Daniela, Torp, Sverre H., Shih, Helen A., Morshed, Ramin A., Young, Jacob S., Magill, Stephen T., Bertero, Luca, Stummer, Walter, Spille, Dorothee Cäcilia, Brokinkel, Benjamin, Oya, Soichi, Miyawaki, Satoru, Saito, Nobuhito, Proescholdt, Martin, Kuroi, Yasuhiro, Gousias, Konstantinos, Simon, Matthias, Moliterno, Jennifer, Prat-Acin, Ricardo, Goutagny, Stéphane, Prabhu, Vikram C., Tsiang, John T., Wach, Johannes, Güresir, Erdem, Yamamoto, Junkoh, Kim, Young Zoon, Lee, Joo Ho, Koshy, Matthew, Perumal, Karthikeyan, Baskaya, Mustafa K., Cannon, Donald M., Shrieve, Dennis C., Suh, Chang Ok, Chang, Jong Hee, Kamenova, Maria, Straumann, Sven, Soleman, Jehuda, Eyüpoglu, Ilker Y., Catalan, Tony, Lui, Austin, Theodosopoulos, Philip V., McDermott, Michael W., Wang, Fang, Guo, Fuyou, Góes, Pedro, de Paiva Neto, Manoel Antonio, Jamshidi, Aria, Komotar, Ricardo, Ivan, Michael, Luther, Evan, Souhami, Luis, Guiot, Marie Christine, Csonka, Tamás, Endo, Toshiki, Barrett, Olivia Claire, Jensen, Randy, Gupta, Tejpal, Patel, Akash J., Klisch, Tiemo J., Kim, Jun Won, Maiuri, Francesco, Barresi, Valeria, Tabernero, María Dolores, Skyrman, Simon, Broechner, Anders, Bach, Mathias Jacobsen, Law, Ian, Scheie, David, Kristensen, Bjarne Winther, Munch, Tina Nørgaard, Meling, Torstein, Fugleholm, Kåre, Blanche, Paul, and Mathiesen, Tiit
Abstract: Background The risk of recurrence is overestimated by the Kaplan–Meier method when competing events, such as death without recurrence, are present. Such overestimation can be avoided by using the Aalen-Johansen method, which is a direct extension of Kaplan–Meier that accounts for competing events. Meningiomas commonly occur in older individuals and have slow-growing properties, thereby warranting competing risk analysis. The extent to which competing events are considered in meningioma literature is unknown, and the consequences of using incorrect methodologies in meningioma recurrence risk analysis have not been investigated. Methods We surveyed articles indexed on PubMed since 2020 to assess the usage of competing risk analysis in recent meningioma literature. To compare recurrence risk estimates obtained through Kaplan–Meier and Aalen-Johansen methods, we applied our international database comprising ~ 8,000 patients with a primary meningioma collected from 42 institutions. Results Of 513 articles, 169 were eligible for full-text screening. There were 6,537 eligible cases from our PERNS database. The discrepancy between the results obtained by Kaplan–Meier and Aalen-Johansen was negligible among low-grade lesions and younger individuals. The discrepancy increased substantially in the patient groups associated with higher rates of competing events (older patients with high-grade lesions). Conclusion The importance of considering competing events in recurrence risk analysis is poorly recognized as only 6% of the studies we surveyed employed Aalen-Johansen analyses. Consequently, most of the previous literature has overestimated the risk of recurrence. The overestimation was negligible for studies involving low-grade lesions in younger individuals; however, overestimation might have been substantial for studies on high-grade lesions., Background: The risk of recurrence is overestimated by the Kaplan–Meier method when competing events, such as death without recurrence, are present. Such overestimation can be avoided by using the Aalen-Johansen method, which is a direct extension of Kaplan–Meier that accounts for competing events. Meningiomas commonly occur in older individuals and have slow-growing properties, thereby warranting competing risk analysis. The extent to which competing events are considered in meningioma literature is unknown, and the consequences of using incorrect methodologies in meningioma recurrence risk analysis have not been investigated. Methods: We surveyed articles indexed on PubMed since 2020 to assess the usage of competing risk analysis in recent meningioma literature. To compare recurrence risk estimates obtained through Kaplan–Meier and Aalen-Johansen methods, we applied our international database comprising ~ 8,000 patients with a primary meningioma collected from 42 institutions. Results: Of 513 articles, 169 were eligible for full-text screening. There were 6,537 eligible cases from our PERNS database. The discrepancy between the results obtained by Kaplan–Meier and Aalen-Johansen was negligible among low-grade lesions and younger individuals. The discrepancy increased substantially in the patient groups associated with higher rates of competing events (older patients with high-grade lesions). Conclusion: The importance of considering competing events in recurrence risk analysis is poorly recognized as only 6% of the studies we surveyed employed Aalen-Johansen analyses. Consequently, most of the previous literature has overestimated the risk of recurrence. The overestimation was negligible for studies involving low-grade lesions in younger individuals; however, overestimation might have been substantial for studies on high-grade lesions.
Published: 2024

4. Measurement of the 1-jettiness event shape observable in deep-inelastic electron-proton scattering at HERA

Author: The H1 collaboration, Andreev, V., Arratia, M., Baghdasaryan, A., Baty, A., Begzsuren, K., Bolz, A., Boudry, V., Brandt, G., Britzger, D., Buniatyan, A., Bystritskaya, L., Campbell, A. J., Avila, K. B. Cantun, Cerny, K., Chekelian, V., Chen, Z., Contreras, J. G., Cvach, J., Dainton, J. B., Daum, K., Deshpande, A., Diaconu, C., Drees, A., Eckerlin, G., Egli, S., Elsen, E., Favart, L., Fedotov, A., Feltesse, J., Fleischer, M., Fomenko, A., Gal, C., Gayler, J., Goerlich, L., Gogitidze, N., Gouzevitch, M., Grab, C., Greenshaw, T., Grindhammer, G., Haidt, D., Henderson, R. C. W., Hessler, J., Hladký, J., Hoffmann, D., Horisberger, R., Hreus, T., Huber, F., Jacobs, P. M., Jacquet, M., Janssen, T., Jung, A. W., Katzy, J., Kiesling, C., Klein, M., Kleinwort, C., Klest, H. T., Kluth, S., Kogler, R., Kostka, P., Kretzschmar, J., Krücker, D., Krüger, K., Landon, M. P. J., Lange, W., Laycock, P., Lee, S. H., Levonian, S., Li, W., Lin, J., Lipka, K., List, B., List, J., Lobodzinski, B., Long, O. R., Malinovski, E., Martyn, H. -U., Maxfield, S. J., Mehta, A., Meyer, A. B., Meyer, J., Mikocki, S., Mikuni, V. M., Mondal, M. M., Müller, K., Nachman, B., Naumann, Th., Newman, P. R., Niebuhr, C., Nowak, G., Olsson, J. E., Ozerov, D., Park, S., Pascaud, C., Patel, G. D., Perez, E., Petrukhin, A., Picuric, I., Pitzl, D., Polifka, R., Preins, S., Radescu, V., Raicevic, N., Ravdandorj, T., Reichelt, D., Reimer, P., Rizvi, E., Robmann, P., Roosen, R., Rostovtsev, A., Rotaru, M., Sankey, D. P. C., Sauter, M., Sauvan, E., Schmitt, S., Schmookler, B. A., Schnell, G., Schoeffel, L., Schöning, A., Schumann, S., Sefkow, F., Shushkevich, S., Soloviev, Y., Sopicki, P., South, D., Specka, A., Steder, M., Stella, B., Stöcker, L., Straumann, U., Sun, C., Sykora, T., Thompson, P. D., Acosta, F. Torales, Traynor, D., Tseepeldorj, B., Tu, Z., Tustin, G., Valkárová, A., Vallée, C., Van Mechelen, P., Wegener, D., Wünsch, E., Žáček, J., Zhang, J., Zhang, Z., Žlebčík, R., Zohrabyan, H., Zomer, F., The H1 collaboration, Andreev, V., Arratia, M., Baghdasaryan, A., Baty, A., Begzsuren, K., Bolz, A., Boudry, V., Brandt, G., Britzger, D., Buniatyan, A., Bystritskaya, L., Campbell, A. J., Avila, K. B. Cantun, Cerny, K., Chekelian, V., Chen, Z., Contreras, J. G., Cvach, J., Dainton, J. B., Daum, K., Deshpande, A., Diaconu, C., Drees, A., Eckerlin, G., Egli, S., Elsen, E., Favart, L., Fedotov, A., Feltesse, J., Fleischer, M., Fomenko, A., Gal, C., Gayler, J., Goerlich, L., Gogitidze, N., Gouzevitch, M., Grab, C., Greenshaw, T., Grindhammer, G., Haidt, D., Henderson, R. C. W., Hessler, J., Hladký, J., Hoffmann, D., Horisberger, R., Hreus, T., Huber, F., Jacobs, P. M., Jacquet, M., Janssen, T., Jung, A. W., Katzy, J., Kiesling, C., Klein, M., Kleinwort, C., Klest, H. T., Kluth, S., Kogler, R., Kostka, P., Kretzschmar, J., Krücker, D., Krüger, K., Landon, M. P. J., Lange, W., Laycock, P., Lee, S. H., Levonian, S., Li, W., Lin, J., Lipka, K., List, B., List, J., Lobodzinski, B., Long, O. R., Malinovski, E., Martyn, H. -U., Maxfield, S. J., Mehta, A., Meyer, A. B., Meyer, J., Mikocki, S., Mikuni, V. M., Mondal, M. M., Müller, K., Nachman, B., Naumann, Th., Newman, P. R., Niebuhr, C., Nowak, G., Olsson, J. E., Ozerov, D., Park, S., Pascaud, C., Patel, G. D., Perez, E., Petrukhin, A., Picuric, I., Pitzl, D., Polifka, R., Preins, S., Radescu, V., Raicevic, N., Ravdandorj, T., Reichelt, D., Reimer, P., Rizvi, E., Robmann, P., Roosen, R., Rostovtsev, A., Rotaru, M., Sankey, D. P. C., Sauter, M., Sauvan, E., Schmitt, S., Schmookler, B. A., Schnell, G., Schoeffel, L., Schöning, A., Schumann, S., Sefkow, F., Shushkevich, S., Soloviev, Y., Sopicki, P., South, D., Specka, A., Steder, M., Stella, B., Stöcker, L., Straumann, U., Sun, C., Sykora, T., Thompson, P. D., Acosta, F. Torales, Traynor, D., Tseepeldorj, B., Tu, Z., Tustin, G., Valkárová, A., Vallée, C., Van Mechelen, P., Wegener, D., Wünsch, E., Žáček, J., Zhang, J., Zhang, Z., Žlebčík, R., Zohrabyan, H., and Zomer, F.
Abstract: The H1 Collaboration reports the first measurement of the 1-jettiness event shape observable $\tau_1^b$ in neutral-current deep-inelastic electron-proton scattering (DIS). The observable $\tau_1^b$ is equivalent to a thrust observable defined in the Breit frame. The data sample was collected at the HERA $ep$ collider in the years 2003-2007 with center-of-mass energy of $\sqrt{s}=319\,\text{GeV}$, corresponding to an integrated luminosity of $351.1\,\text{pb}^{-1}$. Triple differential cross sections are provided as a function of $\tau_1^b$, event virtuality $Q^2$, and inelasticity $y$, in the kinematic region $Q^2>150\,\text{GeV}^{2}$. Single differential cross section are provided as a function of $\tau_1^b$ in a limited kinematic range. Double differential cross sections are measured, in contrast, integrated over $\tau_1^b$ and represent the inclusive neutral-current DIS cross section measured as a function of $Q^2$ and $y$. The data are compared to a variety of predictions and include classical and modern Monte Carlo event generators, predictions in fixed-order perturbative QCD where calculations up to $\mathcal{O}(\alpha_s^3)$ are available for $\tau_1^b$ or inclusive DIS, and resummed predictions at next-to-leading logarithmic accuracy matched to fixed order predictions at $\mathcal{O}(\alpha_s^2)$. These comparisons reveal sensitivity of the 1-jettiness observable to QCD parton shower and resummation effects, as well as the modeling of hadronization and fragmentation. Within their range of validity, the fixed-order predictions provide a good description of the data. Monte Carlo event generators are predictive over the full measured range and hence their underlying models and parameters can be constrained by comparing to the presented data., Comment: 45 pages, 38 tables, 13 figures
Published: 2024

5. Measurement of groomed event shape observables in deep-inelastic electron-proton scattering at HERA

Author: The H1 collaboration, Andreev, V., Arratia, M., Baghdasaryan, A., Baty, A., Begzsuren, K., Bolz, A., Boudry, V., Brandt, G., Britzger, D., Buniatyan, A., Bystritskaya, L., Campbell, A. J., Avila, K. B. Cantun, Cerny, K., Chekelian, V., Chen, Z., Contreras, J. G., Cvach, J., Dainton, J. B., Daum, K., Deshpande, A., Diaconu, C., Drees, A., Eckerlin, G., Egli, S., Elsen, E., Favart, L., Fedotov, A., Feltesse, J., Fleischer, M., Fomenko, A., Gal, C., Gayler, J., Goerlich, L., Gogitidze, N., Gouzevitch, M., Grab, C., Greenshaw, T., Grindhammer, G., Haidt, D., Henderson, R. C. W., Hessler, J., Hladký, J., Hoffmann, D., Horisberger, R., Hreus, T., Huber, F., Jacobs, P. M., Jacquet, M., Janssen, T., Jung, A. W., Katzy, J., Kiesling, C., Klein, M., Kleinwort, C., Klest, H. T., Kogler, R., Kostka, P., Kretzschmar, J., Krücker, D., Krüger, K., Landon, M. P. J., Lange, W., Laycock, P., Lee, S. H., Levonian, S., Li, W., Lin, J., Lipka, K., List, B., List, J., Lobodzinski, B., Long, O. R., Malinovski, E., Martyn, H. -U., Maxfield, S. J., Mehta, A., Meyer, A. B., Meyer, J., Mikocki, S., Mikuni, V. M., Mondal, M. M., Müller, K., Nachman, B., Naumann, Th., Newman, P. R., Niebuhr, C., Nowak, G., Olsson, J. E., Ozerov, D., Park, S., Pascaud, C., Patel, G. D., Perez, E., Petrukhin, A., Picuric, I., Pitzl, D., Polifka, R., Preins, S., Radescu, V., Raicevic, N., Ravdandorj, T., Reichelt, D., Reimer, P., Rizvi, E., Robmann, P., Roosen, R., Rostovtsev, A., Rotaru, M., Sankey, D. P. C., Sauter, M., Sauvan, E., Schmitt, S., Schmookler, B. A., Schnell, G., Schoeffel, L., Schöning, A., Schumann, S., Sefkow, F., Shushkevich, S., Soloviev, Y., Sopicki, P., South, D., Specka, A., Steder, M., Stella, B., Stöcker, L., Straumann, U., Sun, C., Sykora, T., Thompson, P. D., Acosta, F. Torales, Traynor, D., Tseepeldorj, B., Tu, Z., Tustin, G., Valkárová, A., Vallée, C., Van Mechelen, P., Wegener, D., Wünsch, E., Žáček, J., Zhang, J., Zhang, Z., Žlebčík, R., Zohrabyan, H., Zomer, F., The H1 collaboration, Andreev, V., Arratia, M., Baghdasaryan, A., Baty, A., Begzsuren, K., Bolz, A., Boudry, V., Brandt, G., Britzger, D., Buniatyan, A., Bystritskaya, L., Campbell, A. J., Avila, K. B. Cantun, Cerny, K., Chekelian, V., Chen, Z., Contreras, J. G., Cvach, J., Dainton, J. B., Daum, K., Deshpande, A., Diaconu, C., Drees, A., Eckerlin, G., Egli, S., Elsen, E., Favart, L., Fedotov, A., Feltesse, J., Fleischer, M., Fomenko, A., Gal, C., Gayler, J., Goerlich, L., Gogitidze, N., Gouzevitch, M., Grab, C., Greenshaw, T., Grindhammer, G., Haidt, D., Henderson, R. C. W., Hessler, J., Hladký, J., Hoffmann, D., Horisberger, R., Hreus, T., Huber, F., Jacobs, P. M., Jacquet, M., Janssen, T., Jung, A. W., Katzy, J., Kiesling, C., Klein, M., Kleinwort, C., Klest, H. T., Kogler, R., Kostka, P., Kretzschmar, J., Krücker, D., Krüger, K., Landon, M. P. J., Lange, W., Laycock, P., Lee, S. H., Levonian, S., Li, W., Lin, J., Lipka, K., List, B., List, J., Lobodzinski, B., Long, O. R., Malinovski, E., Martyn, H. -U., Maxfield, S. J., Mehta, A., Meyer, A. B., Meyer, J., Mikocki, S., Mikuni, V. M., Mondal, M. M., Müller, K., Nachman, B., Naumann, Th., Newman, P. R., Niebuhr, C., Nowak, G., Olsson, J. E., Ozerov, D., Park, S., Pascaud, C., Patel, G. D., Perez, E., Petrukhin, A., Picuric, I., Pitzl, D., Polifka, R., Preins, S., Radescu, V., Raicevic, N., Ravdandorj, T., Reichelt, D., Reimer, P., Rizvi, E., Robmann, P., Roosen, R., Rostovtsev, A., Rotaru, M., Sankey, D. P. C., Sauter, M., Sauvan, E., Schmitt, S., Schmookler, B. A., Schnell, G., Schoeffel, L., Schöning, A., Schumann, S., Sefkow, F., Shushkevich, S., Soloviev, Y., Sopicki, P., South, D., Specka, A., Steder, M., Stella, B., Stöcker, L., Straumann, U., Sun, C., Sykora, T., Thompson, P. D., Acosta, F. Torales, Traynor, D., Tseepeldorj, B., Tu, Z., Tustin, G., Valkárová, A., Vallée, C., Van Mechelen, P., Wegener, D., Wünsch, E., Žáček, J., Zhang, J., Zhang, Z., Žlebčík, R., Zohrabyan, H., and Zomer, F.
Abstract: The H1 Collaboration at HERA reports the first measurement of groomed event shape observables in deep inelastic electron-proton scattering (DIS) at $\sqrt{s}=319$ GeV, using data recorded between the years 2003 and 2007 with an integrated luminosity of $351$ pb$^{-1}$. Event shapes provide incisive probes of perturbative and non-perturbative QCD. Grooming techniques have been used for jet measurements in hadronic collisions; this paper presents the first application of grooming to DIS data. The analysis is carried out in the Breit frame, utilizing the novel Centauro jet clustering algorithm that is designed for DIS event topologies. Events are required to have squared momentum-transfer $Q^2 > 150$ GeV$^2$ and inelasticity $ 0.2 < y < 0.7$. We report measurements of the production cross section of groomed event 1-jettiness and groomed invariant mass for several choices of grooming parameter. Monte Carlo model calculations and analytic calculations based on Soft Collinear Effective Theory are compared to the measurements., Comment: 32 pages, 17 tables, 7 figures, submitted to EPJ C
Published: 2024

6. Observation and differential cross section measurement of neutral current DIS events with an empty hemisphere in the Breit frame

Author: The H1 collaboration, Andreev, V., Arratia, M., Baghdasaryan, A., Baty, A., Begzsuren, K., Bolz, A., Boudry, V., Brandt, G., Britzger, D., Buniatyan, A., Bystritskaya, L., Campbell, A. J., Avila, K. B. Cantun, Cerny, K., Chekelian, V., Chen, Z., Contreras, J. G., Cvach, J., Dainton, J. B., Daum, K., Deshpande, A., Diaconu, C., Drees, A., Eckerlin, G., Egli, S., Elsen, E., Favart, L., Fedotov, A., Feltesse, J., Fleischer, M., Fomenko, A., Gal, C., Gayler, J., Goerlich, L., Gogitidze, N., Gouzevitch, M., Grab, C., Greenshaw, T., Grindhammer, G., Haidt, D., Henderson, R. C. W., Hessler, J., Hladký, J., Hoffmann, D., Horisberger, R., Hreus, T., Huber, F., Jacobs, P. M., Jacquet, M., Janssen, T., Jung, A. W., Katzy, J., Kiesling, C., Klein, M., Kleinwort, C., Klest, H. T., Kluth, S., Kogler, R., Kostka, P., Kretzschmar, J., Krücker, D., Krüger, K., Landon, M. P. J., Lange, W., Laycock, P., Lee, S. H., Levonian, S., Li, W., Lin, J., Lipka, K., List, B., List, J., Lobodzinski, B., Long, O. R., Malinovski, E., Martyn, H. -U., Maxfield, S. J., Mehta, A., Meyer, A. B., Meyer, J., Mikocki, S., Mikuni, V. M., Mondal, M. M., Müller, K., Nachman, B., Naumann, Th., Newman, P. R., Niebuhr, C., Nowak, G., Olsson, J. E., Ozerov, D., Park, S., Pascaud, C., Patel, G. D., Perez, E., Petrukhin, A., Picuric, I., Pitzl, D., Polifka, R., Preins, S., Radescu, V., Raicevic, N., Ravdandorj, T., Reichelt, D., Reimer, P., Rizvi, E., Robmann, P., Roosen, R., Rostovtsev, A., Rotaru, M., Sankey, D. P. C., Sauter, M., Sauvan, E., Schmitt, S., Schmookler, B. A., Schnell, G., Schoeffel, L., Schöning, A., Schumann, S., Sefkow, F., Shushkevich, S., Soloviev, Y., Sopicki, P., South, D., Specka, A., Steder, M., Stella, B., Stöcker, L., Straumann, U., Sun, C., Sykora, T., Thompson, P. D., Acosta, F. Torales, Traynor, D., Tseepeldorj, B., Tu, Z., Tustin, G., Valkárová, A., Vallée, C., Van Mechelen, P., Wegener, D., Wünsch, E., Žáček, J., Zhang, J., Zhang, Z., Žlebčík, R., Zohrabyan, H., Zomer, F., The H1 collaboration, Andreev, V., Arratia, M., Baghdasaryan, A., Baty, A., Begzsuren, K., Bolz, A., Boudry, V., Brandt, G., Britzger, D., Buniatyan, A., Bystritskaya, L., Campbell, A. J., Avila, K. B. Cantun, Cerny, K., Chekelian, V., Chen, Z., Contreras, J. G., Cvach, J., Dainton, J. B., Daum, K., Deshpande, A., Diaconu, C., Drees, A., Eckerlin, G., Egli, S., Elsen, E., Favart, L., Fedotov, A., Feltesse, J., Fleischer, M., Fomenko, A., Gal, C., Gayler, J., Goerlich, L., Gogitidze, N., Gouzevitch, M., Grab, C., Greenshaw, T., Grindhammer, G., Haidt, D., Henderson, R. C. W., Hessler, J., Hladký, J., Hoffmann, D., Horisberger, R., Hreus, T., Huber, F., Jacobs, P. M., Jacquet, M., Janssen, T., Jung, A. W., Katzy, J., Kiesling, C., Klein, M., Kleinwort, C., Klest, H. T., Kluth, S., Kogler, R., Kostka, P., Kretzschmar, J., Krücker, D., Krüger, K., Landon, M. P. J., Lange, W., Laycock, P., Lee, S. H., Levonian, S., Li, W., Lin, J., Lipka, K., List, B., List, J., Lobodzinski, B., Long, O. R., Malinovski, E., Martyn, H. -U., Maxfield, S. J., Mehta, A., Meyer, A. B., Meyer, J., Mikocki, S., Mikuni, V. M., Mondal, M. M., Müller, K., Nachman, B., Naumann, Th., Newman, P. R., Niebuhr, C., Nowak, G., Olsson, J. E., Ozerov, D., Park, S., Pascaud, C., Patel, G. D., Perez, E., Petrukhin, A., Picuric, I., Pitzl, D., Polifka, R., Preins, S., Radescu, V., Raicevic, N., Ravdandorj, T., Reichelt, D., Reimer, P., Rizvi, E., Robmann, P., Roosen, R., Rostovtsev, A., Rotaru, M., Sankey, D. P. C., Sauter, M., Sauvan, E., Schmitt, S., Schmookler, B. A., Schnell, G., Schoeffel, L., Schöning, A., Schumann, S., Sefkow, F., Shushkevich, S., Soloviev, Y., Sopicki, P., South, D., Specka, A., Steder, M., Stella, B., Stöcker, L., Straumann, U., Sun, C., Sykora, T., Thompson, P. D., Acosta, F. Torales, Traynor, D., Tseepeldorj, B., Tu, Z., Tustin, G., Valkárová, A., Vallée, C., Van Mechelen, P., Wegener, D., Wünsch, E., Žáček, J., Zhang, J., Zhang, Z., Žlebčík, R., Zohrabyan, H., and Zomer, F.
Abstract: The Breit frame provides a natural frame to analyze lepton-proton scattering events. In this reference frame, the parton model hard interactions between a quark and an exchanged boson defines the coordinate system such that the struck quark is back-scattered along the virtual photon momentum direction. In Quantum Chromodynamics (QCD), higher order perturbative or non-perturbative effects can change this picture drastically. As Bjorken-$x$ decreases below one half, a rather peculiar event signature is predicted with increasing probability, where no radiation is present in one of the two Breit-frame hemispheres and all emissions are to be found in the other hemisphere. At higher orders in $\alpha_s$ or in the presence of soft QCD effects, predictions of the rate of these events are far from trivial, and that motivates measurements with real data. We report on the first observation of the empty current hemisphere events in electron-proton collisions at the HERA collider using data recorded with the H1 detector at a center-of-mass energy of 319 GeV. The fraction of inclusive neutral-current DIS events with an empty hemisphere is found to be $0.0112 \pm 3.9\,\%_\text{stat} \pm 4.5\,\%_\text{syst} \pm 1.6\,\%_\text{mod}$ in the selected kinematic region of $150< Q^2<1500$ GeV$^2$ and inelasticity $0.14< y<0.7$. The data sample corresponds to an integrated luminosity of 351.1 pb$^{-1}$, sufficient to enable differential cross section measurements of these events. The results show an enhanced discriminating power at lower Bjorken-$x$ among different Monte Carlo event generator predictions., Comment: 13 pages, 5 figures, 2 Tables
Published: 2024

7. Unbinned deep learning jet substructure measurement in high Q2 ep collisions at HERA

Author: Andreev, V., Arratia, M., Baghdasaryan, A., Baty, A., Begzsuren, K., Bolz, A., Boudry, V., Brandt, G., Britzger, D., Buniatyan, A., Bystritskaya, L., Campbell, A.J., Cantun Avila, K.B., Cerny, K., Chekelian, V., Chen, Z., Contreras, J.G., Cvach, J., Dainton, J.B., Daum, K., Deshpande, A., Diaconu, C., Drees, A., Eckerlin, G., Egli, S., Elsen, E., Favart, L., Fedotov, A., Feltesse, J., Fleischer, M., Fomenko, A., Gal, C., Gayler, J., Goerlich, L., Gogitidze, N., Gouzevitch, M., Grab, C., Greenshaw, T., Grindhammer, G., Haidt, D., Henderson, R.C.W., Hessler, J., Hladký, J., Hoffmann, D., Horisberger, R., Hreus, T., Huber, F., Jacobs, P.M., Jacquet, M., Janssen, T., Jung, A.W., Katzy, J., Kiesling, C., Klein, M., Kleinwort, C., Klest, H.T., Kogler, R., Kostka, P., Kretzschmar, J., Krücker, D., Krüger, K., Landon, M.P.J., Lange, W., Laycock, P., Lee, S.H., Levonian, S., Li, W., Lin, J., Lipka, K., List, B., List, J., Lobodzinski, B., Long, O.R., Malinovski, E., Martyn, H.-U., Maxfield, S.J., Mehta, A., Meyer, A.B., Meyer, J., Mikocki, S., Mikuni, V.M., Mondal, M.M., Müller, K., Nachman, B., Naumann, T., Newman, P.R., Niebuhr, C., Nowak, G., Olsson, J.E., Ozerov, D., Park, S., Pascaud, C., Patel, G.D., Perez, E., Petrukhin, A., Picuric, I., Pitzl, D., Polifka, R., Preins, S., Radescu, V., Raicevic, N., Ravdandorj, T., Reimer, P., Rizvi, E., Robmann, P., Roosen, R., Rostovtsev, A., Rotaru, M., Sankey, D.P.C., Sauter, M., Sauvan, E., Schmitt, S., Schmookler, B.A., Schnell, G., Schoeffel, L., Schöning, A., Sefkow, F., Shushkevich, S., Soloviev, Y., Sopicki, P., South, D., Specka, A., Steder, M., Stella, B., Straumann, U., Sun, C., Sykora, T., Thompson, P.D., Torales Acosta, F., Traynor, D., Tseepeldorj, B., Tu, Z., Tustin, G., Valkárová, A., Vallée, C., Van Mechelen, P., Wegener, D., Wünsch, E., Žáček, J., Zhang, J., Zhang, Z., Žlebčík, R., Zohrabyan, H., Zomer, F., Andreev, V., Arratia, M., Baghdasaryan, A., Baty, A., Begzsuren, K., Bolz, A., Boudry, V., Brandt, G., Britzger, D., Buniatyan, A., Bystritskaya, L., Campbell, A.J., Cantun Avila, K.B., Cerny, K., Chekelian, V., Chen, Z., Contreras, J.G., Cvach, J., Dainton, J.B., Daum, K., Deshpande, A., Diaconu, C., Drees, A., Eckerlin, G., Egli, S., Elsen, E., Favart, L., Fedotov, A., Feltesse, J., Fleischer, M., Fomenko, A., Gal, C., Gayler, J., Goerlich, L., Gogitidze, N., Gouzevitch, M., Grab, C., Greenshaw, T., Grindhammer, G., Haidt, D., Henderson, R.C.W., Hessler, J., Hladký, J., Hoffmann, D., Horisberger, R., Hreus, T., Huber, F., Jacobs, P.M., Jacquet, M., Janssen, T., Jung, A.W., Katzy, J., Kiesling, C., Klein, M., Kleinwort, C., Klest, H.T., Kogler, R., Kostka, P., Kretzschmar, J., Krücker, D., Krüger, K., Landon, M.P.J., Lange, W., Laycock, P., Lee, S.H., Levonian, S., Li, W., Lin, J., Lipka, K., List, B., List, J., Lobodzinski, B., Long, O.R., Malinovski, E., Martyn, H.-U., Maxfield, S.J., Mehta, A., Meyer, A.B., Meyer, J., Mikocki, S., Mikuni, V.M., Mondal, M.M., Müller, K., Nachman, B., Naumann, T., Newman, P.R., Niebuhr, C., Nowak, G., Olsson, J.E., Ozerov, D., Park, S., Pascaud, C., Patel, G.D., Perez, E., Petrukhin, A., Picuric, I., Pitzl, D., Polifka, R., Preins, S., Radescu, V., Raicevic, N., Ravdandorj, T., Reimer, P., Rizvi, E., Robmann, P., Roosen, R., Rostovtsev, A., Rotaru, M., Sankey, D.P.C., Sauter, M., Sauvan, E., Schmitt, S., Schmookler, B.A., Schnell, G., Schoeffel, L., Schöning, A., Sefkow, F., Shushkevich, S., Soloviev, Y., Sopicki, P., South, D., Specka, A., Steder, M., Stella, B., Straumann, U., Sun, C., Sykora, T., Thompson, P.D., Torales Acosta, F., Traynor, D., Tseepeldorj, B., Tu, Z., Tustin, G., Valkárová, A., Vallée, C., Van Mechelen, P., Wegener, D., Wünsch, E., Žáček, J., Zhang, J., Zhang, Z., Žlebčík, R., Zohrabyan, H., and Zomer, F.
Published: 2023

8. Hans Sulzer und die 'zweite Gründung' der Schweiz

Author: Nerlicc, Daniel, Wiesmann, Matthias, Nerlicc, D ( Daniel ), Wiesmann, M ( Matthias ), Straumann, Tobias, Nerlicc, Daniel, Wiesmann, Matthias, Nerlicc, D ( Daniel ), Wiesmann, M ( Matthias ), and Straumann, Tobias
Published: 2023

9. Paria inter pares: das Ende der Bank Wegelin

Author: Schönig, Dagmar, Straumann, Tobias, Schönig, Dagmar, and Straumann, Tobias
Abstract: Die Bank Wegelin war bis zu ihrer Auflösung im Jahr 2012 die älteste noch bestehende Bank in der Schweiz. Wie auch andere Banken geriet sie im Zusammenhang mit unversteuerten Vermögen von US-Kunden ins Visier der US-Behörden. Doch im Gegensatz zu anderen Geldinstituten besiegelte der Konflikt mit der US-Justiz das Ende der Bank Wegelin.Dr. Otto Bruderer und Dr. Konrad Hummler, beides ehemalige Teilhaber der Bank, haben die Finanzhistorikerin Dagmar Schönig und den Wirtschaftshistoriker Tobias Straumann beauftragt, den Sachverhalt mit einer Aussensicht aufzuarbeiten unddie Geschichte der Bank für die Nachwelt festzuhalten. Ihr Augenmerk galt nicht zuletzt der Frage, warum damals ausgerechnet eine St. Galler Privatbankverschwinden musste, während fast alle anderen geahndeten Schweizer Banken weiter existieren konnten.Entstanden ist eine umfassende und objektive Darstellung der Geschichte der Bank Wegelin, deren Untergang zu den markantesten Ereignissen der Schweizer Finanzgeschichte zu Beginn des 21. Jahrhunderts gehört.
Published: 2023

10. Princess Diana's Figurations of Pathos in Pablo Larraín’s 'Spencer'

Author: Berndt, Frauke; https://orcid.org/0000-0002-3332-1156, Karremann, Isabel; https://orcid.org/0000-0001-7723-4786, Müller-Wille, Klaus; https://orcid.org/0000-0001-5457-3064, Berndt, F ( Frauke ), Karremann, I ( Isabel ), Müller-Wille, K ( Klaus ), Straumann, Barbara, Berndt, Frauke; https://orcid.org/0000-0002-3332-1156, Karremann, Isabel; https://orcid.org/0000-0001-7723-4786, Müller-Wille, Klaus; https://orcid.org/0000-0001-5457-3064, Berndt, F ( Frauke ), Karremann, I ( Isabel ), Müller-Wille, K ( Klaus ), and Straumann, Barbara
Published: 2023

11. Gamified VR simulation in nursing education : how to generate value with VR in nursing education

Author: Seiler, Roger, Straumann, Ruben, Weber, Christian, Block, Andreas, Seiler, Roger, Straumann, Ruben, Weber, Christian, and Block, Andreas
Abstract: A shortage in nursing staff in Switzerland has reached a high level, and forecasts see the problem growing for the next years as there is a lack of candidates who are willing to sign up for nursing education programs. Prior research suggests that virtual reality (VR) can have positive effects on motivation, learning outcome, and trust. Therefore, we examine if VR in nursing education can help raise the attractiveness of education programs and help raise the number of people signing up for education programs which incorporate VR in their training and education.
Published: 2023

12. Unbinned Deep Learning Jet Substructure Measurement in High $Q^2$ ep collisions at HERA

Author: The H1 collaboration, Andreev, V., Arratia, M., Baghdasaryan, A., Baty, A., Begzsuren, K., Bolz, A., Boudry, V., Brandt, G., Britzger, D., Buniatyan, A., Bystritskaya, L., Campbell, A. J., Avila, K. B. Cantun, Cerny, K., Chekelian, V., Chen, Z., Contreras, J. G., Cvach, J., Dainton, J. B., Daum, K., Deshpande, A., Diaconu, C., Drees, A., Eckerlin, G., Egli, S., Elsen, E., Favart, L., Fedotov, A., Feltesse, J., Fleischer, M., Fomenko, A., Gal, C., Gayler, J., Goerlich, L., Gogitidze, N., Gouzevitch, M., Grab, C., Greenshaw, T., Grindhammer, G., Haidt, D., Henderson, R. C. W., Hessler, J., Hladký, J., Hoffmann, D., Horisberger, R., Hreus, T., Huber, F., Jacobs, P. M., Jacquet, M., Janssen, T., Jung, A. W., Katzy, J., Kiesling, C., Klein, M., Kleinwort, C., Klest, H. T., Kogler, R., Kostka, P., Kretzschmar, J., Krücker, D., Krüger, K., Landon, M. P. J., Lange, W., Laycock, P., Lee, S. H., Levonian, S., Li, W., Lin, J., Lipka, K., List, B., List, J., Lobodzinski, B., Long, O. R., Malinovski, E., Martyn, H. -U., Maxfield, S. J., Mehta, A., Meyer, A. B., Meyer, J., Mikocki, S., Mikuni, V. M., Mondal, M. M., Müller, K., Nachman, B., Naumann, Th., Newman, P. R., Niebuhr, C., Nowak, G., Olsson, J. E., Ozerov, D., Park, S., Pascaud, C., Patel, G. D., Perez, E., Petrukhin, A., Picuric, I., Pitzl, D., Polifka, R., Preins, S., Radescu, V., Raicevic, N., Ravdandorj, T., Reimer, P., Rizvi, E., Robmann, P., Roosen, R., Rostovtsev, A., Rotaru, M., Sankey, D. P. C., Sauter, M., Sauvan, E., Schmitt, S., Schmookler, B. A., Schnell, G., Schoeffel, L., Schöning, A., Sefkow, F., Shushkevich, S., Soloviev, Y., Sopicki, P., South, D., Specka, A., Steder, M., Stella, B., Straumann, U., Sun, C., Sykora, T., Thompson, P. D., Acosta, F. Torales, Traynor, D., Tseepeldorj, B., Tu, Z., Tustin, G., Valkárová, A., Vallée, C., Van Mechelen, P., Wegener, D., Wünsch, E., Žáček, J., Zhang, J., Zhang, Z., Žlebčík, R., Zohrabyan, H., Zomer, F., The H1 collaboration, Andreev, V., Arratia, M., Baghdasaryan, A., Baty, A., Begzsuren, K., Bolz, A., Boudry, V., Brandt, G., Britzger, D., Buniatyan, A., Bystritskaya, L., Campbell, A. J., Avila, K. B. Cantun, Cerny, K., Chekelian, V., Chen, Z., Contreras, J. G., Cvach, J., Dainton, J. B., Daum, K., Deshpande, A., Diaconu, C., Drees, A., Eckerlin, G., Egli, S., Elsen, E., Favart, L., Fedotov, A., Feltesse, J., Fleischer, M., Fomenko, A., Gal, C., Gayler, J., Goerlich, L., Gogitidze, N., Gouzevitch, M., Grab, C., Greenshaw, T., Grindhammer, G., Haidt, D., Henderson, R. C. W., Hessler, J., Hladký, J., Hoffmann, D., Horisberger, R., Hreus, T., Huber, F., Jacobs, P. M., Jacquet, M., Janssen, T., Jung, A. W., Katzy, J., Kiesling, C., Klein, M., Kleinwort, C., Klest, H. T., Kogler, R., Kostka, P., Kretzschmar, J., Krücker, D., Krüger, K., Landon, M. P. J., Lange, W., Laycock, P., Lee, S. H., Levonian, S., Li, W., Lin, J., Lipka, K., List, B., List, J., Lobodzinski, B., Long, O. R., Malinovski, E., Martyn, H. -U., Maxfield, S. J., Mehta, A., Meyer, A. B., Meyer, J., Mikocki, S., Mikuni, V. M., Mondal, M. M., Müller, K., Nachman, B., Naumann, Th., Newman, P. R., Niebuhr, C., Nowak, G., Olsson, J. E., Ozerov, D., Park, S., Pascaud, C., Patel, G. D., Perez, E., Petrukhin, A., Picuric, I., Pitzl, D., Polifka, R., Preins, S., Radescu, V., Raicevic, N., Ravdandorj, T., Reimer, P., Rizvi, E., Robmann, P., Roosen, R., Rostovtsev, A., Rotaru, M., Sankey, D. P. C., Sauter, M., Sauvan, E., Schmitt, S., Schmookler, B. A., Schnell, G., Schoeffel, L., Schöning, A., Sefkow, F., Shushkevich, S., Soloviev, Y., Sopicki, P., South, D., Specka, A., Steder, M., Stella, B., Straumann, U., Sun, C., Sykora, T., Thompson, P. D., Acosta, F. Torales, Traynor, D., Tseepeldorj, B., Tu, Z., Tustin, G., Valkárová, A., Vallée, C., Van Mechelen, P., Wegener, D., Wünsch, E., Žáček, J., Zhang, J., Zhang, Z., Žlebčík, R., Zohrabyan, H., and Zomer, F.
Abstract: The radiation pattern within high energy quark- and gluon-initiated jets (jet substructure) is used extensively as a precision probe of the strong force as well as an environment for optimizing event generators with numerous applications in high energy particle and nuclear physics. Looking at electron-proton collisions is of particular interest as many of the complications present at hadron colliders are absent. A detailed study of modern jet substructure observables, jet angularities, in electron-proton collisions is presented using data recorded using the H1 detector at HERA. The measurement is unbinned and multi-dimensional, using machine learning to correct for detector effects. All of the available reconstructed object information of the respective jets is interpreted by a graph neural network, achieving superior precision on a selected set of jet angularities. Training these networks was enabled by the use of a large number of GPUs in the Perlmutter supercomputer at Berkeley Lab. The particle jets are reconstructed in the laboratory frame, using the $k_{\mathrm{T}}$ jet clustering algorithm. Results are reported at high transverse momentum transfer $Q^2>150$ GeV${}^2$, and inelasticity $0.2 < y < 0.7$. The analysis is also performed in sub-regions of $Q^2$, thus probing scale dependencies of the substructure variables. The data are compared with a variety of predictions and point towards possible improvements of such models., Comment: 25 pages, 10 figures, 8 tables, version accepted by Physics Letters B
Published: 2023
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13. High-throughput analysis of microalgae cell wall permeability in biotechnological production settings

Author: Carpine, R., Fluri, M., Müller, T., Straumann, M., Neutsch, L., Carpine, R., Fluri, M., Müller, T., Straumann, M., and Neutsch, L.
Abstract: Microalgae represent a promising resource for nature-derived compounds in different fields of interest. The rigid microalgae cell wall (composed of a polysaccharide and glycoprotein matrix) provides the cells with a formidable defence against harsh environments, but typically poses a major bottleneck for efficient product extraction, and hence sustainable process setups. The aim of this study was to evaluate the applicability of a high-throughput screening method for microalgae cell wall permeability, based on flow cytometry and titration against the exposure time in proceeding fixation steps. A panel of comparative trials were carried out on Chlorella vulgaris cultures to visualize changes in wall permeability via different fixation and staining techniques (methanol treatment and microwaving). Different intracellular targets were addressed (lipid storage vesicles and DNA) to define the optimal strategy with regard to information content on wall configuration and overall robustness. The tests were carried out for different growth conditions (photoautotrophic and heterotrophic cultures) and process states.The main results showed that both dies efficiently reached their intracellular target depending on fixation conditions, with minimal non-specific staining. Both assay formats yielded valuable, but non-redundant information on the current wall permeability. As expected, analyses targeted to DNA content proved to be more stable over culture time than those directed to lipid depositories, which can subjected to dynamic changes in response to growth conditions.The future perspectives will be to implement the flow cytometric assays as a real-time monitoring tool to exert control over product extraction efficiency in different microalgae strains and biotechnological production settings.
Published: 2023

14. Barrett’s Esophagus in Eosinophilic Esophagitis in Swiss Eosinophilic Esophagitis Cohort Study (SEECS)

Author: Scherer, Roger, Schreiner, Philipp, Rossel, Jean-Benoit, Greuter, Thomas, Burri, Emanuel, Saner, Catherine, Schlag, Christoph, Safroneeva, Ekaterina; https://orcid.org/0000-0002-1505-7750, Schoepfer, Alain, Straumann, Alex, Biedermann, Luc; https://orcid.org/0000-0003-0824-4125, SEECS group, Scherer, Roger, Schreiner, Philipp, Rossel, Jean-Benoit, Greuter, Thomas, Burri, Emanuel, Saner, Catherine, Schlag, Christoph, Safroneeva, Ekaterina; https://orcid.org/0000-0002-1505-7750, Schoepfer, Alain, Straumann, Alex, Biedermann, Luc; https://orcid.org/0000-0003-0824-4125, and SEECS group
Abstract: INTRODUCTION: There is a complex interrelationship between gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE) potentially promoting the occurrence and modulating severity of each other reciprocally. Presence of Barrett’s esophagus (BE) is a defining factor for the diagnosis of GERD. While several studies investigated the potential impact of concomitant GERD on the presentation and course of EoE, little was known with regards to BE in EoE patients. METHODS: We analyzed prospectively collected clinical, endoscopic, and histological data from patients enrolled in the Swiss Eosinophilic Esophagitis Cohort Study (SEECS) regarding differences between EoE patients with (EoE/BE+) versus without BE (EoE/BE−) and determined the prevalence of BE in EoE patients. RESULTS: Among a total of 509 EoE patients included in our analysis, 24 (4.7%) had concomitant BE with a high male preponderance (EoE/BE+ 83.3% vs. EoE/BE− 74.4%). While there were no differences in dysphagia, odynophagia was significantly (12.5 vs. 3.1%, p = 0.047) more common in EoE/BE+ versus EoE/BE−. General well-being at last follow-up was significantly lower in EoE/BE+. Endoscopically, we observed an increased incidence of fixed rings in the proximal esophagus in EoE/BE+ (70.8 vs. 46.3% in EoE/BE−, p = 0.019) and a higher fraction of patients with a severe fibrosis in the proximal histological specimen (8.7 vs. 1.6% in EoE/BE, p = 0.017). CONCLUSION: Our study reveals that BE is twice as frequent in EoE patients compared to general population. Despite many similarities between EoE patients with and without BE, the finding of a more pronounced remodeling in EoE patients with Barrett is noteworthy.
Published: 2023

15. Biomechanical induction of mild brain trauma in larval zebrafish: effects on visual startle reflex habituation

Author: Beppi, Carolina; https://orcid.org/0000-0002-1614-2084, Penner, Marco, Straumann, Dominik; https://orcid.org/0000-0002-5349-7650, Bögli, Stefan Yu; https://orcid.org/0000-0001-5386-0811, Beppi, Carolina; https://orcid.org/0000-0002-1614-2084, Penner, Marco, Straumann, Dominik; https://orcid.org/0000-0002-5349-7650, and Bögli, Stefan Yu; https://orcid.org/0000-0001-5386-0811
Abstract: A mild traumatic brain injury is a neurological disturbance of transient or/and chronic nature after a direct blow of the head/neck or exposure of the body to impulsive biomechanical forces, indirectly affecting the brain. The neuropathological events leading to the clinical signs, symptoms and functional disturbances are still elusive due to a lack of sensitive brain-screening tools. Animal models offer the potential to study neural pathomechanisms in close detail. We recently proposed a non-invasive protocol for inducing concussion-like symptoms in larval zebrafish via exposure to rapid linearly accelerating-decelerating body motion. By mean of auditory 'startle reflex habituation' assessments-an established neurophysiological health index-we probed acute and chronic effects that mirror human concussion patterns. This study aimed at expanding our previous work by assessing the ensuing effects with visual-as opposed to auditory-'startle reflex habituation' quantifications, by using the same methodology. We observed that immediately after impact exposure, the fish showed impaired sensory reactivity and smaller decay constant, possibly mirroring acute signs of confusion or loss of consciousness in humans. By 30-min post-injury, the fish display temporary signs of visual hypersensitivity, manifested as increased visuomotor reactivity and a relatively enlarged decay constant, putatively reflecting human post-concussive sign of visual hypersensitivity. In the following 5-24 h, the exposed fish progressively develop chronic signs of CNS dysfunction, in the form of low startle responsivity. However, the preserved decay constant suggests that neuroplastic changes may occur to restore CNS functioning after undergoing the 'concussive procedure'. The observed findings expand our previous work providing further behavioural evidence for the model. Limitations that still require addressment are discussed, advancing further behavioural and microscopic analyses that would be neces
Published: 2023

16. Editorial: Impacts of VEMP and VHIT on the diagnosis of vestibular diseases

Author: Tarnutzer, Alexander Andrea, Seo, Toru, Fujimoto, Chisato, Straumann, Dominik; https://orcid.org/0000-0002-5349-7650, Murofushi, Toshihisa, Tarnutzer, Alexander Andrea, Seo, Toru, Fujimoto, Chisato, Straumann, Dominik; https://orcid.org/0000-0002-5349-7650, and Murofushi, Toshihisa
Published: 2023

17. Unbinned deep learning jet substructure measurement in high $Q^2$ ep collisions at HERA

Author: Andreev, V, Arratia, M, Baghdasaryan, A, Baty, A, Begzsuren, K, Bolz, A, Boudry, V, Brandt, G, Britzger, D, Buniatyan, A, Bystritskaya, L, Campbell, A J, Cantun Avila, K B, Cerny, K, Chekelian, V, Chen, Z, Contreras, J G, Cvach, J, Dainton, J B, Daum, K, Deshpande, A, Diaconu, C, Drees, A, Eckerlin, G, Egli, S, Elsen, E, Favart, L, Fedotov, A, Feltesse, J, Fleischer, M, et al, Robmann, Peter, Müller, Katharina, Straumann, Ulrich, Andreev, V, Arratia, M, Baghdasaryan, A, Baty, A, Begzsuren, K, Bolz, A, Boudry, V, Brandt, G, Britzger, D, Buniatyan, A, Bystritskaya, L, Campbell, A J, Cantun Avila, K B, Cerny, K, Chekelian, V, Chen, Z, Contreras, J G, Cvach, J, Dainton, J B, Daum, K, Deshpande, A, Diaconu, C, Drees, A, Eckerlin, G, Egli, S, Elsen, E, Favart, L, Fedotov, A, Feltesse, J, Fleischer, M, et al, Robmann, Peter, Müller, Katharina, and Straumann, Ulrich
Abstract: The radiation pattern within high energy quark- and gluon-initiated jets (jet substructure) is used extensively as a precision probe of the strong force as well as an environment for optimizing event generators with numerous applications in high energy particle and nuclear physics. Looking at electron-proton collisions is of particular interest as many of the complications present at hadron colliders are absent. A detailed study of modern jet substructure observables, jet angularities, in electron-proton collisions is presented using data recorded using the H1 detector at HERA. The measurement is unbinned and multi-dimensional, using machine learning to correct for detector effects. All of the available reconstructed object information of the respective jets is interpreted by a graph neural network, achieving superior precision on a selected set of jet angularities. Training these networks was enabled by the use of a large number of GPUs in the Perlmutter supercomputer at Berkeley Lab. The particle jets are reconstructed in the laboratory frame, using the kt jet clustering algorithm. Results are reported at high transverse momentum transfer $Q^2$>150 GeV$^2$ , and inelasticity 0.2
Published: 2023

18. Enforceable duties: Cicero and Kant on the legal nature of political order

Author: Straumann, Benjamin; https://orcid.org/0000-0003-4115-7496 and Straumann, Benjamin; https://orcid.org/0000-0003-4115-7496
Abstract: This article seeks to show the importance of Cicero for Kant by pointing out the systematic relationship between their respective views on ethics and law. Cicero was important to Kant because Cicero had already elaborated an imperative, “quasi-jural” conception of duty or obligation. Cicero had also already prefigured the distinction between ethical duties and duties of justice. The article does not establish any direct historical influence, but points out interesting systematic overlaps. The most important in the realm of ethics are a universal rationalism; a rule-based normative framework of duty; and skepticism about (Cicero), or rejection of (Kant), eudaimonism. In the realm of political theory, it is the centrality of law and of property that unites both thinkers; both reject voluntarism in thinking that consensus flows from the right external laws, not the other way around, and thus creates a juridical community; and lastly, both Cicero and Kant believe that transparence, or publicity, is a key ideal that might be presupposed by both the ethical and the juridical domain. The article thus shows that both Cicero and Kant separate ethics from law, but there are indications that neither has given up the aspiration to bridge the two realms on a higher plane. This reading of Kant yields both a more Ciceronian Kant and allows us to perceive Kantian aspects of Cicero.
Published: 2023

19. Imaging increased metabolism in the spinal cord in mice after middle cerebral artery occlusion

Author: Ni, Ruiqing, Straumann, Nadja, Fazio, Serana, Dean-Ben, Xose Luis, Louloudis, Georgios, Keller, Claudia, Razansky, Daniel, Ametamey, Simon, Mu, Linjing, Nombela-Arrieta, César, Klohs, Jan, Ni, Ruiqing, Straumann, Nadja, Fazio, Serana, Dean-Ben, Xose Luis, Louloudis, Georgios, Keller, Claudia, Razansky, Daniel, Ametamey, Simon, Mu, Linjing, Nombela-Arrieta, César, and Klohs, Jan
Abstract: Emerging evidence indicates crosstalk between the brain and hematopoietic system following cerebral ischemia. Here, we investigated metabolism and oxygenation in the spleen and spinal cord in a transient middle cerebral artery occlusion (tMCAO) model. Sham-operated and tMCAO mice underwent [$^{18}$F]fluorodeoxyglucose (FDG)-positron emission tomography (PET) to assess glucose metabolism. Naïve, sham-operated and tMCAO mice underwent multispectral optoacoustic tomography (MSOT) assisted by quantitative model-based reconstruction and unmixing algorithms for accurate mapping of oxygenation patterns in peripheral tissues at 24 h after reperfusion. We found increased [$^{18}$F]FDG uptake and reduced MSOT oxygen saturation, indicating hypoxia in the thoracic spinal cord of tMCAO mice compared with sham-operated mice but not in the spleen. Reduced spleen size was observed in tMCAO mice compared with sham-operated mice ex vivo. tMCAO led to an increase in the numbers of mature T cells in femoral bone marrow tissues, concomitant with a stark reduction in these cell subsets in the spleen and peripheral blood. The combination of quantitative PET and MSOT thus enabled observation of hypoxia and increased metabolic activity in the spinal cord of tMCAO mice at 24 h after occlusion compared to sham-operated mice.
Published: 2023

20. Visualizing alpha-synuclein and iron deposition in M83 mouse model of Parkinson's disease in vivo

Author: Straumann, Nadja, Combes, Benjamin F, Ben, Xose Luis Dean, Sternke-Hoffmann, Rebecca, Gerez, Juan A, Dias, Ines, Chen, Zhenyue; https://orcid.org/0000-0001-9508-7521, Watts, Benjamin, Rostami, Iman, Shi, Kuangyu; https://orcid.org/0000-0002-8714-3084, Rominger, Axel; https://orcid.org/0000-0002-1954-736X, Baumann, Christian R; https://orcid.org/0000-0003-3417-1978, Luo, Jinghui, Noain, Daniela; https://orcid.org/0000-0001-5482-7933, Nitsch, Roger M, Okamura, Nobuyuki, Razansky, Daniel; https://orcid.org/0000-0001-8676-0964, Ni, Ruiqing; https://orcid.org/0000-0002-0793-2113, Straumann, Nadja, Combes, Benjamin F, Ben, Xose Luis Dean, Sternke-Hoffmann, Rebecca, Gerez, Juan A, Dias, Ines, Chen, Zhenyue; https://orcid.org/0000-0001-9508-7521, Watts, Benjamin, Rostami, Iman, Shi, Kuangyu; https://orcid.org/0000-0002-8714-3084, Rominger, Axel; https://orcid.org/0000-0002-1954-736X, Baumann, Christian R; https://orcid.org/0000-0003-3417-1978, Luo, Jinghui, Noain, Daniela; https://orcid.org/0000-0001-5482-7933, Nitsch, Roger M, Okamura, Nobuyuki, Razansky, Daniel; https://orcid.org/0000-0001-8676-0964, and Ni, Ruiqing; https://orcid.org/0000-0002-0793-2113
Abstract: BACKGROUND Abnormal alpha-synuclein and iron accumulation in the brain play an important role in Parkinson's disease (PD). Herein, we aim at visualizing alpha-synuclein inclusions and iron deposition in the brains of M83 (A53T) mouse models of PD in vivo . METHODS Fluorescently labelled pyrimidoindole-derivative THK-565 was characterized by using recombinant fibrils and brains from 10-11 months old M83 mice, which subsequently underwent in vivo concurrent wide-field fluorescence and volumetric multispectral optoacoustic tomography (vMSOT) imaging. The in vivo results were verified against structural and susceptibility weighted imaging (SWI) magnetic resonance imaging (MRI) at 9.4 Tesla and scanning transmission X-ray microscopy (STXM) of perfused brains. Brain slice immunofluorescence and Prussian blue staining were further performed to validate the detection of alpha-synuclein inclusions and iron deposition in the brain, respectively. RESULTS THK-565 showed increased fluorescence upon binding to recombinant alpha-synuclein fibrils and alpha-synuclein inclusions in post-mortem brain slices from patients with Parkinson's disease and M83 mice. i.v. administration of THK-565 in M83 mice showed higher cerebral retention at 20 and 40 minutes post-injection by wide-field fluorescence compared to non-transgenic littermate mice, in congruence with the vMSOT findings. SWI/phase images and Prussian blue indicated the accumulation of iron deposits in the brains of M83 mice, presumably in the Fe $^{3+}$ form, as evinced by the STXM results. CONCLUSION We demonstrated in vivo mapping of alpha-synuclein by means of non-invasive epifluorescence and vMSOT imaging assisted with a targeted THK-565 label and SWI/STXM identification of iron deposits in M83 mouse brains ex vivo .
Published: 2023

21. Earth-vertical motion perception assessment using an elevator: a feasibility study

Author: Schellenberg, Simona, Straumann, Dominik; https://orcid.org/0000-0002-5349-7650, Green, David Andrew, Schuetz, Philipp, Zehnder, Yves, Swanenburg, Jaap; https://orcid.org/0000-0002-1754-9206, Schellenberg, Simona, Straumann, Dominik; https://orcid.org/0000-0002-5349-7650, Green, David Andrew, Schuetz, Philipp, Zehnder, Yves, and Swanenburg, Jaap; https://orcid.org/0000-0002-1754-9206
Abstract: A feasible, inexpensive, rapid, and easy-to-use method to measure vestibular vertical movement perception is needed to assess the sacculus-mediated low-frequency otolith function of dizzy patients. To evaluate the feasibility of reaction time assessment in response to vertical motion induced by an elevator in healthy young individuals. We recorded linear acceleration/deceleration reaction times (LA-RT/LD-RT) of 20 healthy (13 female) subjects (mean age: 22 years ± 1 SD) as a measure of vertical vestibular motion perception. LA-RT/LD-RT were defined as the time elapsed from the start of elevator acceleration or deceleration to the time at which subjects in a sitting position indicated perceiving a change in velocity by pushing a button with their thumb. The light reaction time was measured as a reference. All 20 subjects tolerated the assessment with repeated elevator rides and reported no adverse events. Over all experiments, one upward and four downward rides had to be excluded for technical reasons (2.5%). The fraction of premature button presses varied among the four conditions, possibly related to elevator vibration (upward rides: LA-RT-up 66%, LD-RT-up 0%; downward rides: LA-RT-down 12%, LD-RT-down 4%). Thus LD-RT-up yielded the most robust results. The reaction time to earth-vertical deceleration elicited by an elevator provides a consistent indicator of linear vestibular motion perception in healthy humans. The testing procedure is inexpensive and easy to use. Deceleration on upward rides yielded the most robust measurements.
Published: 2023

22. On the liberties of the ancients: licentiousness, equal rights, and the rule of law

Author: Edelstein, Dan, Straumann, Benjamin; https://orcid.org/0000-0003-4115-7496, Edelstein, Dan, and Straumann, Benjamin; https://orcid.org/0000-0003-4115-7496
Abstract: In this article, we discuss Greek and Roman conceptions of liberty. The supposedly ‘neo-Roman’ view of liberty as non-domination is really derived from negative Greek models, we argue, while Roman authors devised an alternative understanding of liberty that rested on the equality of legal rights. In this ‘paleo-Roman’ model, as long as the law was the same for all, you were free; whether or not you participated in making the law was not a constitutive feature of liberty. In essence, this Roman theory was a theory of freedom as the rule of law and the guarantee of equal rights, especially due process rights. For this Roman concept of ‘legal liberty,’ as we call it,political participation was neither necessary nor sufficient. Theorized by Cicero and historicized by Livy, the Roman understanding of freedom flourished in early-modern times, proving important to paradigmatic republican authors such as Machiavelli and Rousseau as well as to Hobbes, whose work we discuss as a helpful point of comparison.
Published: 2023

23. Erratum to: Bilateral vestibulopathy: Diagnostic criteria Consensus document of the Classification Committee of the Bárány Society

Author: Strupp, Michael, Kim, Ji-Soo, Murofushi, Toshihisa, Straumann, Dominik, Jen, Joanna C, Rosengren, Sally M, Della Santina, Charles C, Kingma, Herman, Strupp, Michael, Kim, Ji-Soo, Murofushi, Toshihisa, Straumann, Dominik, Jen, Joanna C, Rosengren, Sally M, Della Santina, Charles C, and Kingma, Herman
Abstract: This paper describes the diagnostic criteria for bilateral vestibulopathy (BVP) by the Classification Committee of the Bárány Society. The diagnosis of BVP is based on the patient history, bedside examination and laboratory evaluation. Bilateral vestibulopathy is a chronic vestibular syndrome which is characterized by unsteadiness when walking or standing, which worsen in darkness and/or on uneven ground, or during head motion. Additionally, patients may describe head or body movement-induced blurred vision or oscillopsia. There are typically no symptoms while sitting or lying down under static conditions. The diagnosis of BVP requires bilaterally significantly impaired or absent function of the vestibulo-ocular reflex (VOR). This can be diagnosed for the high frequency range of the angular VOR by the head impulse test (HIT), the video-HIT (vHIT) and the scleral coil technique and for the low frequency range by caloric testing. The moderate range can be examined by the sinusoidal or step profile rotational chair test. For the diagnosis of BVP, the horizontal angular VOR gain on both sides should be <0.6 (angular velocity 150–300°/s) and/or the sum of the maximal peak velocities of the slow phase caloric-induced nystagmus for stimulation with warm and cold water on each side <6°/s and/or the horizontal angular VOR gain <0.1 upon sinusoidal stimulation on a rotatory chair (0.1 Hz, Vmax = 50°/sec) and/or a phase lead >68 degrees (time constant of <5 seconds). For the diagnosis of probable BVP the above mentioned symptoms and a bilaterally pathological bedside HIT are required. Complementary tests that may be used but are currently not included in the definition are: a) dynamic visual acuity (a decrease of ≥0.2 logMAR is considered pathological); b) Romberg (indicating a sensory deficit of the vestibular or somatosensory system and therefore not specific); and c) abnormal cervical and ocular vestibular-evoked myogenic potentials for otolith function. At present the scie
Published: 2023

24. Purple Llama CyberSecEval: A Secure Coding Benchmark for Language Models

Author: Bhatt, Manish, Chennabasappa, Sahana, Nikolaidis, Cyrus, Wan, Shengye, Evtimov, Ivan, Gabi, Dominik, Song, Daniel, Ahmad, Faizan, Aschermann, Cornelius, Fontana, Lorenzo, Frolov, Sasha, Giri, Ravi Prakash, Kapil, Dhaval, Kozyrakis, Yiannis, LeBlanc, David, Milazzo, James, Straumann, Aleksandar, Synnaeve, Gabriel, Vontimitta, Varun, Whitman, Spencer, Saxe, Joshua, Bhatt, Manish, Chennabasappa, Sahana, Nikolaidis, Cyrus, Wan, Shengye, Evtimov, Ivan, Gabi, Dominik, Song, Daniel, Ahmad, Faizan, Aschermann, Cornelius, Fontana, Lorenzo, Frolov, Sasha, Giri, Ravi Prakash, Kapil, Dhaval, Kozyrakis, Yiannis, LeBlanc, David, Milazzo, James, Straumann, Aleksandar, Synnaeve, Gabriel, Vontimitta, Varun, Whitman, Spencer, and Saxe, Joshua
Abstract: This paper presents CyberSecEval, a comprehensive benchmark developed to help bolster the cybersecurity of Large Language Models (LLMs) employed as coding assistants. As what we believe to be the most extensive unified cybersecurity safety benchmark to date, CyberSecEval provides a thorough evaluation of LLMs in two crucial security domains: their propensity to generate insecure code and their level of compliance when asked to assist in cyberattacks. Through a case study involving seven models from the Llama 2, Code Llama, and OpenAI GPT large language model families, CyberSecEval effectively pinpointed key cybersecurity risks. More importantly, it offered practical insights for refining these models. A significant observation from the study was the tendency of more advanced models to suggest insecure code, highlighting the critical need for integrating security considerations in the development of sophisticated LLMs. CyberSecEval, with its automated test case generation and evaluation pipeline covers a broad scope and equips LLM designers and researchers with a tool to broadly measure and enhance the cybersecurity safety properties of LLMs, contributing to the development of more secure AI systems.
Published: 2023

25. The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants

Author: Rothenberger, Sylvia, Hurdiss, Daniel L, Walser, Marcel, Malvezzi, Francesca, Mayor, Jennifer, Ryter, Sarah, Moreno, Hector, Liechti, Nicole, Bosshart, Andreas, Iss, Chloé, Calabro, Valérie, Cornelius, Andreas, Hospodarsch, Tanja, Neculcea, Alexandra, Looser, Thamar, Schlegel, Anja, Fontaine, Simon, Villemagne, Denis, Paladino, Maria, Schiegg, Dieter, Mangold, Susanne, Reichen, Christian, Radom, Filip, Kaufmann, Yvonne, Schaible, Doris, Schlegel, Iris, Zitt, Christof, Sigrist, Gabriel, Straumann, Marcel, Wolter, Julia, Comby, Marco, Sacarcelik, Feyza, Drulyte, Ieva, Lyoo, Heyrhyoung, Wang, Chunyan, Li, Wentao, Du, Wenjuan, Binz, H Kaspar, Herrup, Rachel, Lusvarghi, Sabrina, Neerukonda, Sabari Nath, Vassell, Russell, Wang, Wei, Adler, Julia M, Eschke, Kathrin, Nascimento, Mariana, Abdelgawad, Azza, Gruber, Achim D, Bushe, Judith, Kershaw, Olivia, Knutson, Charles G, Balavenkatraman, Kamal K, Ramanathan, Krishnan, Wyler, Emanuel, Teixeira Alves, Luiz Gustavo, Lewis, Seth, Watson, Randall, Haeuptle, Micha A, Zürcher, Alexander, Dawson, Keith M, Steiner, Daniel, Weiss, Carol D, Amstutz, Patrick, van Kuppeveld, Frank J M, Stumpp, Michael T, Bosch, Berend-Jan, Engler, Olivier, Trimpert, Jakob, Rothenberger, Sylvia, Hurdiss, Daniel L, Walser, Marcel, Malvezzi, Francesca, Mayor, Jennifer, Ryter, Sarah, Moreno, Hector, Liechti, Nicole, Bosshart, Andreas, Iss, Chloé, Calabro, Valérie, Cornelius, Andreas, Hospodarsch, Tanja, Neculcea, Alexandra, Looser, Thamar, Schlegel, Anja, Fontaine, Simon, Villemagne, Denis, Paladino, Maria, Schiegg, Dieter, Mangold, Susanne, Reichen, Christian, Radom, Filip, Kaufmann, Yvonne, Schaible, Doris, Schlegel, Iris, Zitt, Christof, Sigrist, Gabriel, Straumann, Marcel, Wolter, Julia, Comby, Marco, Sacarcelik, Feyza, Drulyte, Ieva, Lyoo, Heyrhyoung, Wang, Chunyan, Li, Wentao, Du, Wenjuan, Binz, H Kaspar, Herrup, Rachel, Lusvarghi, Sabrina, Neerukonda, Sabari Nath, Vassell, Russell, Wang, Wei, Adler, Julia M, Eschke, Kathrin, Nascimento, Mariana, Abdelgawad, Azza, Gruber, Achim D, Bushe, Judith, Kershaw, Olivia, Knutson, Charles G, Balavenkatraman, Kamal K, Ramanathan, Krishnan, Wyler, Emanuel, Teixeira Alves, Luiz Gustavo, Lewis, Seth, Watson, Randall, Haeuptle, Micha A, Zürcher, Alexander, Dawson, Keith M, Steiner, Daniel, Weiss, Carol D, Amstutz, Patrick, van Kuppeveld, Frank J M, Stumpp, Michael T, Bosch, Berend-Jan, Engler, Olivier, and Trimpert, Jakob
Abstract: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with potential resistance to existing drugs emphasizes the need for new therapeutic modalities with broad variant activity. Here we show that ensovibep, a trispecific DARPin (designed ankyrin repeat protein) clinical candidate, can engage the three units of the spike protein trimer of SARS-CoV-2 and inhibit ACE2 binding with high potency, as revealed by cryo-electron microscopy analysis. The cooperative binding together with the complementarity of the three DARPin modules enable ensovibep to inhibit frequent SARS-CoV-2 variants, including Omicron sublineages BA.1 and BA.2. In Roborovski dwarf hamsters infected with SARS-CoV-2, ensovibep reduced fatality similarly to a standard-of-care monoclonal antibody (mAb) cocktail. When used as a single agent in viral passaging experiments in vitro, ensovibep reduced the emergence of escape mutations in a similar fashion to the same mAb cocktail. These results support further clinical evaluation of ensovibep as a broad variant alternative to existing targeted therapies for Coronavirus Disease 2019 (COVID-19).
Published: 2022

26. The spatial relationship between the MRI lesion and intraoperative electrocorticography in focal epilepsy surgery

Author: KNF, Projectafdeling FNE, Team Innovatie Research MTKF, Other research (not in main researchprogram), MS Radiologie, Brain, Cancer, Circulatory Health, Projectafdeling KIND, Neurochirurgen, Neurologie, Straumann, Sven, Schaft, Eline, Noordmans, Herke Jan, Dankbaar, Jan Willem, Otte, Willem M., Van Steenis, Josee, Smits, Paul, Zweiphenning, Willemiek, Van Eijsden, Pieter, Gebbink, Tineke, Mariani, Luigi, Van't Klooster, Maryse A., Zijlmans, Maeike, KNF, Projectafdeling FNE, Team Innovatie Research MTKF, Other research (not in main researchprogram), MS Radiologie, Brain, Cancer, Circulatory Health, Projectafdeling KIND, Neurochirurgen, Neurologie, Straumann, Sven, Schaft, Eline, Noordmans, Herke Jan, Dankbaar, Jan Willem, Otte, Willem M., Van Steenis, Josee, Smits, Paul, Zweiphenning, Willemiek, Van Eijsden, Pieter, Gebbink, Tineke, Mariani, Luigi, Van't Klooster, Maryse A., and Zijlmans, Maeike
Published: 2022

27. The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants

Author: Virologie, Rothenberger, Sylvia, Hurdiss, Daniel L, Walser, Marcel, Malvezzi, Francesca, Mayor, Jennifer, Ryter, Sarah, Moreno, Hector, Liechti, Nicole, Bosshart, Andreas, Iss, Chloé, Calabro, Valérie, Cornelius, Andreas, Hospodarsch, Tanja, Neculcea, Alexandra, Looser, Thamar, Schlegel, Anja, Fontaine, Simon, Villemagne, Denis, Paladino, Maria, Schiegg, Dieter, Mangold, Susanne, Reichen, Christian, Radom, Filip, Kaufmann, Yvonne, Schaible, Doris, Schlegel, Iris, Zitt, Christof, Sigrist, Gabriel, Straumann, Marcel, Wolter, Julia, Comby, Marco, Sacarcelik, Feyza, Drulyte, Ieva, Lyoo, Heyrhyoung, Wang, Chunyan, Li, Wentao, Du, Wenjuan, Binz, H Kaspar, Herrup, Rachel, Lusvarghi, Sabrina, Neerukonda, Sabari Nath, Vassell, Russell, Wang, Wei, Adler, Julia M, Eschke, Kathrin, Nascimento, Mariana, Abdelgawad, Azza, Gruber, Achim D, Bushe, Judith, Kershaw, Olivia, Knutson, Charles G, Balavenkatraman, Kamal K, Ramanathan, Krishnan, Wyler, Emanuel, Teixeira Alves, Luiz Gustavo, Lewis, Seth, Watson, Randall, Haeuptle, Micha A, Zürcher, Alexander, Dawson, Keith M, Steiner, Daniel, Weiss, Carol D, Amstutz, Patrick, van Kuppeveld, Frank J M, Stumpp, Michael T, Bosch, Berend-Jan, Engler, Olivier, Trimpert, Jakob, Virologie, Rothenberger, Sylvia, Hurdiss, Daniel L, Walser, Marcel, Malvezzi, Francesca, Mayor, Jennifer, Ryter, Sarah, Moreno, Hector, Liechti, Nicole, Bosshart, Andreas, Iss, Chloé, Calabro, Valérie, Cornelius, Andreas, Hospodarsch, Tanja, Neculcea, Alexandra, Looser, Thamar, Schlegel, Anja, Fontaine, Simon, Villemagne, Denis, Paladino, Maria, Schiegg, Dieter, Mangold, Susanne, Reichen, Christian, Radom, Filip, Kaufmann, Yvonne, Schaible, Doris, Schlegel, Iris, Zitt, Christof, Sigrist, Gabriel, Straumann, Marcel, Wolter, Julia, Comby, Marco, Sacarcelik, Feyza, Drulyte, Ieva, Lyoo, Heyrhyoung, Wang, Chunyan, Li, Wentao, Du, Wenjuan, Binz, H Kaspar, Herrup, Rachel, Lusvarghi, Sabrina, Neerukonda, Sabari Nath, Vassell, Russell, Wang, Wei, Adler, Julia M, Eschke, Kathrin, Nascimento, Mariana, Abdelgawad, Azza, Gruber, Achim D, Bushe, Judith, Kershaw, Olivia, Knutson, Charles G, Balavenkatraman, Kamal K, Ramanathan, Krishnan, Wyler, Emanuel, Teixeira Alves, Luiz Gustavo, Lewis, Seth, Watson, Randall, Haeuptle, Micha A, Zürcher, Alexander, Dawson, Keith M, Steiner, Daniel, Weiss, Carol D, Amstutz, Patrick, van Kuppeveld, Frank J M, Stumpp, Michael T, Bosch, Berend-Jan, Engler, Olivier, and Trimpert, Jakob
Published: 2022

28. Development of a core outcome set for therapeutic studies in eosinophilic esophagitis (COREOS)

Author: Ma, Christopher, Schoepfer, Alain M., Dellon, Evan S., Bredenoord, Albert J., Chehade, Mirna, Collins, Margaret H., Feagan, Brian G., Furuta, Glenn T., Gupta, Sandeep K., Hirano, Ikuo, Jairath, Vipul, Katzka, David A., Pai, Rish K., Rothenberg, Marc E., Straumann, Alex, Aceves, Seema S., Alexander, Jeffrey A., Arva, Nicoleta C., Atkins, Dan, Biedermann, Luc, Blanchard, Carine, Cianferoni, Antonella, Ciriza de los Rios, Constanza, Clayton, Frederic, Davis, Carla M., de Bortoli, Nicola, Dias, Jorge A., Falk, Gary W., Genta, Robert M., Ghaffari, Gisoo, Gonsalves, Nirmala, Greuter, Thomas, Hopp, Russell, Hsu Blatman, Karen S., Jensen, Elizabeth T., Johnston, Doug, Kagalwalla, Amir F., Larsson, Helen M., Leung, John, Louis, Hubert, Masterson, Joanne C., Menard-Katcher, Calies, Menard-Katcher, Paul A., Moawad, Fouad J., Muir, Amanda B., Mukkada, Vincent A., Penagini, Roberto, Pesek, Robert D., Peterson, Kathryn, Putnam, Philip E., Ravelli, Alberto, Savarino, Edoardo V., Schlag, Christoph, Schreiner, Philipp, Simon, Dagmar, Smyrk, Thomas C., Spergel, Jonathan M., Taft, Tiffany H., Terreehorst, Ingrid, Vanuytsel, Tim, Venter, Carina, Vieira, Mario C., Vieth, Michael, Vlieg-Boerstra, Berber, von Arnim, Ulrike, Walker, Marjorie M., Wechsler, Joshua B., Woodland, Philip, Woosley, John T., Yang, Guang-Yu, Zevit, Noam, Safroneeva, Ekaterina, Ma, Christopher, Schoepfer, Alain M., Dellon, Evan S., Bredenoord, Albert J., Chehade, Mirna, Collins, Margaret H., Feagan, Brian G., Furuta, Glenn T., Gupta, Sandeep K., Hirano, Ikuo, Jairath, Vipul, Katzka, David A., Pai, Rish K., Rothenberg, Marc E., Straumann, Alex, Aceves, Seema S., Alexander, Jeffrey A., Arva, Nicoleta C., Atkins, Dan, Biedermann, Luc, Blanchard, Carine, Cianferoni, Antonella, Ciriza de los Rios, Constanza, Clayton, Frederic, Davis, Carla M., de Bortoli, Nicola, Dias, Jorge A., Falk, Gary W., Genta, Robert M., Ghaffari, Gisoo, Gonsalves, Nirmala, Greuter, Thomas, Hopp, Russell, Hsu Blatman, Karen S., Jensen, Elizabeth T., Johnston, Doug, Kagalwalla, Amir F., Larsson, Helen M., Leung, John, Louis, Hubert, Masterson, Joanne C., Menard-Katcher, Calies, Menard-Katcher, Paul A., Moawad, Fouad J., Muir, Amanda B., Mukkada, Vincent A., Penagini, Roberto, Pesek, Robert D., Peterson, Kathryn, Putnam, Philip E., Ravelli, Alberto, Savarino, Edoardo V., Schlag, Christoph, Schreiner, Philipp, Simon, Dagmar, Smyrk, Thomas C., Spergel, Jonathan M., Taft, Tiffany H., Terreehorst, Ingrid, Vanuytsel, Tim, Venter, Carina, Vieira, Mario C., Vieth, Michael, Vlieg-Boerstra, Berber, von Arnim, Ulrike, Walker, Marjorie M., Wechsler, Joshua B., Woodland, Philip, Woosley, John T., Yang, Guang-Yu, Zevit, Noam, and Safroneeva, Ekaterina
Abstract: Background: End points used to determine treatment efficacy in eosinophilic esophagitis (EoE) have evolved over time. With multiple novel therapies in development for EoE, harmonization of outcomes measures will facilitate evidence synthesis and appraisal when comparing different treatments. Objective: We sought to develop a core outcome set (COS) for controlled and observational studies of pharmacologic and diet interventions in adult and pediatric patients with EoE. Methods: Candidate outcomes were generated from systematic literature reviews and patient engagement interviews and surveys. Consensus was established using an iterative Delphi process, with items voted on using a 9-point Likert scale and with feedback from other participants to allow score refinement.
Published: 2022

29. Development of a core outcome set for therapeutic studies in eosinophilic esophagitis (COREOS)

Author: Ma, Christopher, Schoepfer, Alain M., Dellon, Evan S., Bredenoord, Albert J., Chehade, Mirna, Collins, Margaret H., Feagan, Brian G., Furuta, Glenn T., Gupta, Sandeep K., Hirano, Ikuo, Jairath, Vipul, Katzka, David A., Pai, Rish K., Rothenberg, Marc E., Straumann, Alex, Aceves, Seema S., Alexander, Jeffrey A., Arva, Nicoleta C., Atkins, Dan, Biedermann, Luc, Blanchard, Carine, Cianferoni, Antonella, Ciriza de los Rios, Constanza, Clayton, Frederic, Davis, Carla M., de Bortoli, Nicola, Dias, Jorge A., Falk, Gary W., Genta, Robert M., Ghaffari, Gisoo, Gonsalves, Nirmala, Greuter, Thomas, Hopp, Russell, Hsu Blatman, Karen S., Jensen, Elizabeth T., Johnston, Doug, Kagalwalla, Amir F., Larsson, Helen M., Leung, John, Louis, Hubert, Masterson, Joanne C., Menard-Katcher, Calies, Menard-Katcher, Paul A., Moawad, Fouad J., Muir, Amanda B., Mukkada, Vincent A., Penagini, Roberto, Pesek, Robert D., Peterson, Kathryn, Putnam, Philip E., Ravelli, Alberto, Savarino, Edoardo V., Schlag, Christoph, Schreiner, Philipp, Simon, Dagmar, Smyrk, Thomas C., Spergel, Jonathan M., Taft, Tiffany H., Terreehorst, Ingrid, Vanuytsel, Tim, Venter, Carina, Vieira, Mario C., Vieth, Michael, Vlieg-Boerstra, Berber, von Arnim, Ulrike, Walker, Marjorie M., Wechsler, Joshua B., Woodland, Philip, Woosley, John T., Yang, Guang-Yu, Zevit, Noam, Safroneeva, Ekaterina, Ma, Christopher, Schoepfer, Alain M., Dellon, Evan S., Bredenoord, Albert J., Chehade, Mirna, Collins, Margaret H., Feagan, Brian G., Furuta, Glenn T., Gupta, Sandeep K., Hirano, Ikuo, Jairath, Vipul, Katzka, David A., Pai, Rish K., Rothenberg, Marc E., Straumann, Alex, Aceves, Seema S., Alexander, Jeffrey A., Arva, Nicoleta C., Atkins, Dan, Biedermann, Luc, Blanchard, Carine, Cianferoni, Antonella, Ciriza de los Rios, Constanza, Clayton, Frederic, Davis, Carla M., de Bortoli, Nicola, Dias, Jorge A., Falk, Gary W., Genta, Robert M., Ghaffari, Gisoo, Gonsalves, Nirmala, Greuter, Thomas, Hopp, Russell, Hsu Blatman, Karen S., Jensen, Elizabeth T., Johnston, Doug, Kagalwalla, Amir F., Larsson, Helen M., Leung, John, Louis, Hubert, Masterson, Joanne C., Menard-Katcher, Calies, Menard-Katcher, Paul A., Moawad, Fouad J., Muir, Amanda B., Mukkada, Vincent A., Penagini, Roberto, Pesek, Robert D., Peterson, Kathryn, Putnam, Philip E., Ravelli, Alberto, Savarino, Edoardo V., Schlag, Christoph, Schreiner, Philipp, Simon, Dagmar, Smyrk, Thomas C., Spergel, Jonathan M., Taft, Tiffany H., Terreehorst, Ingrid, Vanuytsel, Tim, Venter, Carina, Vieira, Mario C., Vieth, Michael, Vlieg-Boerstra, Berber, von Arnim, Ulrike, Walker, Marjorie M., Wechsler, Joshua B., Woodland, Philip, Woosley, John T., Yang, Guang-Yu, Zevit, Noam, and Safroneeva, Ekaterina
Abstract: End points used to determine treatment efficacy in eosinophilic esophagitis (EoE) have evolved over time. With multiple novel therapies in development for EoE, harmonization of outcomes measures will facilitate evidence synthesis and appraisal when comparing different treatments. Objective We sought to develop a core outcome set (COS) for controlled and observational studies of pharmacologic and diet interventions in adult and pediatric patients with EoE. Methods Candidate outcomes were generated from systematic literature reviews and patient engagement interviews and surveys. Consensus was established using an iterative Delphi process, with items voted on using a 9-point Likert scale and with feedback from other participants to allow score refinement. Consensus meetings were held to ratify the outcome domains of importance and the core outcome measures. Stakeholders were recruited internationally and included adult and pediatric gastroenterologists, allergists, dieticians, pathologists, psychologists, researchers, and methodologists. Results The COS consists of 4 outcome domains for controlled and observational studies: histopathology, endoscopy, patient-reported symptoms, and EoE-specific quality of life. A total of 69 stakeholders (response rate 95.8%) prioritized 42 outcomes in a 2-round Delphi process, and the final ratification meeting generated consensus on 33 outcome measures. These included measurement of the peak eosinophil count, Eosinophilic Esophagitis Histology Scoring System, Eosinophilic Esophagitis Endoscopic Reference Score, and patient-reported measures of dysphagia and quality of life. Conclusions This interdisciplinary collaboration involving global stakeholders has produced a COS that can be applied to adult and pediatric studies of pharmacologic and diet therapies for EoE and will facilitate meaningful treatment comparisons and improve the quality of data synthesis.
Published: 2022

30. Development of a core outcome set for therapeutic studies in eosinophilic esophagitis (COREOS)

Author: Ma, Christopher, Schoepfer, Alain M., Dellon, Evan S., Bredenoord, Albert J., Chehade, Mirna, Collins, Margaret H., Feagan, Brian G., Furuta, Glenn T., Gupta, Sandeep K., Hirano, Ikuo, Jairath, Vipul, Katzka, David A., Pai, Rish K., Rothenberg, Marc E., Straumann, Alex, Aceves, Seema S., Alexander, Jeffrey A., Arva, Nicoleta C., Atkins, Dan, Biedermann, Luc, Blanchard, Carine, Cianferoni, Antonella, Ciriza de los Rios, Constanza, Clayton, Frederic, Davis, Carla M., de Bortoli, Nicola, Dias, Jorge A., Falk, Gary W., Genta, Robert M., Ghaffari, Gisoo, Gonsalves, Nirmala, Greuter, Thomas, Hopp, Russell, Hsu Blatman, Karen S., Jensen, Elizabeth T., Johnston, Doug, Kagalwalla, Amir F., Larsson, Helen M., Leung, John, Louis, Hubert, Masterson, Joanne C., Menard-Katcher, Calies, Menard-Katcher, Paul A., Moawad, Fouad J., Muir, Amanda B., Mukkada, Vincent A., Penagini, Roberto, Pesek, Robert D., Peterson, Kathryn, Putnam, Philip E., Ravelli, Alberto, Savarino, Edoardo V., Schlag, Christoph, Schreiner, Philipp, Simon, Dagmar, Smyrk, Thomas C., Spergel, Jonathan M., Taft, Tiffany H., Terreehorst, Ingrid, Vanuytsel, Tim, Venter, Carina, Vieira, Mario C., Vieth, Michael, Vlieg-Boerstra, Berber, von Arnim, Ulrike, Walker, Marjorie M., Wechsler, Joshua B., Woodland, Philip, Woosley, John T., Yang, Guang-Yu, Zevit, Noam, Safroneeva, Ekaterina, Ma, Christopher, Schoepfer, Alain M., Dellon, Evan S., Bredenoord, Albert J., Chehade, Mirna, Collins, Margaret H., Feagan, Brian G., Furuta, Glenn T., Gupta, Sandeep K., Hirano, Ikuo, Jairath, Vipul, Katzka, David A., Pai, Rish K., Rothenberg, Marc E., Straumann, Alex, Aceves, Seema S., Alexander, Jeffrey A., Arva, Nicoleta C., Atkins, Dan, Biedermann, Luc, Blanchard, Carine, Cianferoni, Antonella, Ciriza de los Rios, Constanza, Clayton, Frederic, Davis, Carla M., de Bortoli, Nicola, Dias, Jorge A., Falk, Gary W., Genta, Robert M., Ghaffari, Gisoo, Gonsalves, Nirmala, Greuter, Thomas, Hopp, Russell, Hsu Blatman, Karen S., Jensen, Elizabeth T., Johnston, Doug, Kagalwalla, Amir F., Larsson, Helen M., Leung, John, Louis, Hubert, Masterson, Joanne C., Menard-Katcher, Calies, Menard-Katcher, Paul A., Moawad, Fouad J., Muir, Amanda B., Mukkada, Vincent A., Penagini, Roberto, Pesek, Robert D., Peterson, Kathryn, Putnam, Philip E., Ravelli, Alberto, Savarino, Edoardo V., Schlag, Christoph, Schreiner, Philipp, Simon, Dagmar, Smyrk, Thomas C., Spergel, Jonathan M., Taft, Tiffany H., Terreehorst, Ingrid, Vanuytsel, Tim, Venter, Carina, Vieira, Mario C., Vieth, Michael, Vlieg-Boerstra, Berber, von Arnim, Ulrike, Walker, Marjorie M., Wechsler, Joshua B., Woodland, Philip, Woosley, John T., Yang, Guang-Yu, Zevit, Noam, and Safroneeva, Ekaterina
Abstract: End points used to determine treatment efficacy in eosinophilic esophagitis (EoE) have evolved over time. With multiple novel therapies in development for EoE, harmonization of outcomes measures will facilitate evidence synthesis and appraisal when comparing different treatments. Objective We sought to develop a core outcome set (COS) for controlled and observational studies of pharmacologic and diet interventions in adult and pediatric patients with EoE. Methods Candidate outcomes were generated from systematic literature reviews and patient engagement interviews and surveys. Consensus was established using an iterative Delphi process, with items voted on using a 9-point Likert scale and with feedback from other participants to allow score refinement. Consensus meetings were held to ratify the outcome domains of importance and the core outcome measures. Stakeholders were recruited internationally and included adult and pediatric gastroenterologists, allergists, dieticians, pathologists, psychologists, researchers, and methodologists. Results The COS consists of 4 outcome domains for controlled and observational studies: histopathology, endoscopy, patient-reported symptoms, and EoE-specific quality of life. A total of 69 stakeholders (response rate 95.8%) prioritized 42 outcomes in a 2-round Delphi process, and the final ratification meeting generated consensus on 33 outcome measures. These included measurement of the peak eosinophil count, Eosinophilic Esophagitis Histology Scoring System, Eosinophilic Esophagitis Endoscopic Reference Score, and patient-reported measures of dysphagia and quality of life. Conclusions This interdisciplinary collaboration involving global stakeholders has produced a COS that can be applied to adult and pediatric studies of pharmacologic and diet therapies for EoE and will facilitate meaningful treatment comparisons and improve the quality of data synthesis.
Published: 2022

31. Development of a core outcome set for therapeutic studies in eosinophilic esophagitis (COREOS)

Author: Ma, Christopher, Schoepfer, Alain M., Dellon, Evan S., Bredenoord, Albert J., Chehade, Mirna, Collins, Margaret H., Feagan, Brian G., Furuta, Glenn T., Gupta, Sandeep K., Hirano, Ikuo, Jairath, Vipul, Katzka, David A., Pai, Rish K., Rothenberg, Marc E., Straumann, Alex, Aceves, Seema S., Alexander, Jeffrey A., Arva, Nicoleta C., Atkins, Dan, Biedermann, Luc, Blanchard, Carine, Cianferoni, Antonella, Ciriza de los Rios, Constanza, Clayton, Frederic, Davis, Carla M., de Bortoli, Nicola, Dias, Jorge A., Falk, Gary W., Genta, Robert M., Ghaffari, Gisoo, Gonsalves, Nirmala, Greuter, Thomas, Hopp, Russell, Hsu Blatman, Karen S., Jensen, Elizabeth T., Johnston, Doug, Kagalwalla, Amir F., Larsson, Helen M., Leung, John, Louis, Hubert, Masterson, Joanne C., Menard-Katcher, Calies, Menard-Katcher, Paul A., Moawad, Fouad J., Muir, Amanda B., Mukkada, Vincent A., Penagini, Roberto, Pesek, Robert D., Peterson, Kathryn, Putnam, Philip E., Ravelli, Alberto, Savarino, Edoardo V., Schlag, Christoph, Schreiner, Philipp, Simon, Dagmar, Smyrk, Thomas C., Spergel, Jonathan M., Taft, Tiffany H., Terreehorst, Ingrid, Vanuytsel, Tim, Venter, Carina, Vieira, Mario C., Vieth, Michael, Vlieg-Boerstra, Berber, von Arnim, Ulrike, Walker, Marjorie M., Wechsler, Joshua B., Woodland, Philip, Woosley, John T., Yang, Guang-Yu, Zevit, Noam, Safroneeva, Ekaterina, Ma, Christopher, Schoepfer, Alain M., Dellon, Evan S., Bredenoord, Albert J., Chehade, Mirna, Collins, Margaret H., Feagan, Brian G., Furuta, Glenn T., Gupta, Sandeep K., Hirano, Ikuo, Jairath, Vipul, Katzka, David A., Pai, Rish K., Rothenberg, Marc E., Straumann, Alex, Aceves, Seema S., Alexander, Jeffrey A., Arva, Nicoleta C., Atkins, Dan, Biedermann, Luc, Blanchard, Carine, Cianferoni, Antonella, Ciriza de los Rios, Constanza, Clayton, Frederic, Davis, Carla M., de Bortoli, Nicola, Dias, Jorge A., Falk, Gary W., Genta, Robert M., Ghaffari, Gisoo, Gonsalves, Nirmala, Greuter, Thomas, Hopp, Russell, Hsu Blatman, Karen S., Jensen, Elizabeth T., Johnston, Doug, Kagalwalla, Amir F., Larsson, Helen M., Leung, John, Louis, Hubert, Masterson, Joanne C., Menard-Katcher, Calies, Menard-Katcher, Paul A., Moawad, Fouad J., Muir, Amanda B., Mukkada, Vincent A., Penagini, Roberto, Pesek, Robert D., Peterson, Kathryn, Putnam, Philip E., Ravelli, Alberto, Savarino, Edoardo V., Schlag, Christoph, Schreiner, Philipp, Simon, Dagmar, Smyrk, Thomas C., Spergel, Jonathan M., Taft, Tiffany H., Terreehorst, Ingrid, Vanuytsel, Tim, Venter, Carina, Vieira, Mario C., Vieth, Michael, Vlieg-Boerstra, Berber, von Arnim, Ulrike, Walker, Marjorie M., Wechsler, Joshua B., Woodland, Philip, Woosley, John T., Yang, Guang-Yu, Zevit, Noam, and Safroneeva, Ekaterina
Abstract: Background: End points used to determine treatment efficacy in eosinophilic esophagitis (EoE) have evolved over time. With multiple novel therapies in development for EoE, harmonization of outcomes measures will facilitate evidence synthesis and appraisal when comparing different treatments. Objective: We sought to develop a core outcome set (COS) for controlled and observational studies of pharmacologic and diet interventions in adult and pediatric patients with EoE. Methods: Candidate outcomes were generated from systematic literature reviews and patient engagement interviews and surveys. Consensus was established using an iterative Delphi process, with items voted on using a 9-point Likert scale and with feedback from other participants to allow score refinement.
Published: 2022

32. The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants

Author: Virologie, Rothenberger, Sylvia, Hurdiss, Daniel L, Walser, Marcel, Malvezzi, Francesca, Mayor, Jennifer, Ryter, Sarah, Moreno, Hector, Liechti, Nicole, Bosshart, Andreas, Iss, Chloé, Calabro, Valérie, Cornelius, Andreas, Hospodarsch, Tanja, Neculcea, Alexandra, Looser, Thamar, Schlegel, Anja, Fontaine, Simon, Villemagne, Denis, Paladino, Maria, Schiegg, Dieter, Mangold, Susanne, Reichen, Christian, Radom, Filip, Kaufmann, Yvonne, Schaible, Doris, Schlegel, Iris, Zitt, Christof, Sigrist, Gabriel, Straumann, Marcel, Wolter, Julia, Comby, Marco, Sacarcelik, Feyza, Drulyte, Ieva, Lyoo, Heyrhyoung, Wang, Chunyan, Li, Wentao, Du, Wenjuan, Binz, H Kaspar, Herrup, Rachel, Lusvarghi, Sabrina, Neerukonda, Sabari Nath, Vassell, Russell, Wang, Wei, Adler, Julia M, Eschke, Kathrin, Nascimento, Mariana, Abdelgawad, Azza, Gruber, Achim D, Bushe, Judith, Kershaw, Olivia, Knutson, Charles G, Balavenkatraman, Kamal K, Ramanathan, Krishnan, Wyler, Emanuel, Teixeira Alves, Luiz Gustavo, Lewis, Seth, Watson, Randall, Haeuptle, Micha A, Zürcher, Alexander, Dawson, Keith M, Steiner, Daniel, Weiss, Carol D, Amstutz, Patrick, van Kuppeveld, Frank J M, Stumpp, Michael T, Bosch, Berend-Jan, Engler, Olivier, Trimpert, Jakob, Virologie, Rothenberger, Sylvia, Hurdiss, Daniel L, Walser, Marcel, Malvezzi, Francesca, Mayor, Jennifer, Ryter, Sarah, Moreno, Hector, Liechti, Nicole, Bosshart, Andreas, Iss, Chloé, Calabro, Valérie, Cornelius, Andreas, Hospodarsch, Tanja, Neculcea, Alexandra, Looser, Thamar, Schlegel, Anja, Fontaine, Simon, Villemagne, Denis, Paladino, Maria, Schiegg, Dieter, Mangold, Susanne, Reichen, Christian, Radom, Filip, Kaufmann, Yvonne, Schaible, Doris, Schlegel, Iris, Zitt, Christof, Sigrist, Gabriel, Straumann, Marcel, Wolter, Julia, Comby, Marco, Sacarcelik, Feyza, Drulyte, Ieva, Lyoo, Heyrhyoung, Wang, Chunyan, Li, Wentao, Du, Wenjuan, Binz, H Kaspar, Herrup, Rachel, Lusvarghi, Sabrina, Neerukonda, Sabari Nath, Vassell, Russell, Wang, Wei, Adler, Julia M, Eschke, Kathrin, Nascimento, Mariana, Abdelgawad, Azza, Gruber, Achim D, Bushe, Judith, Kershaw, Olivia, Knutson, Charles G, Balavenkatraman, Kamal K, Ramanathan, Krishnan, Wyler, Emanuel, Teixeira Alves, Luiz Gustavo, Lewis, Seth, Watson, Randall, Haeuptle, Micha A, Zürcher, Alexander, Dawson, Keith M, Steiner, Daniel, Weiss, Carol D, Amstutz, Patrick, van Kuppeveld, Frank J M, Stumpp, Michael T, Bosch, Berend-Jan, Engler, Olivier, and Trimpert, Jakob
Published: 2022

33. Unruhe im Kleinstaat: der Schweizer Generalstreik von 1918 im internationalen Vergleich

Author: Senn, Martin Andreas, Straumann, Tobias, Senn, Martin Andreas, and Straumann, Tobias
Abstract: Im November 1918 bricht in der Schweiz ein Generalstreik aus. Welche Gründe stehen dahinter – die Verschlechterung des Lebensstandards oder die politischen Spannungen am Ende des Ersten Weltkriegs? Die Autoren vergleichen die schweizerischen Verhältnisse mit denen in anderen neutralen europäischen Kleinstaaten und zeigen so, dass die politischen Gründe weitaus wichtiger waren als bisher in der Forschung angenommen. Vor allem die fehlende Integration der Sozialdemokratie war entscheidend. Während die Sozialdemokraten etwa in Dänemark, Schweden und den Niederlanden Einfluss nehmen konnten, blieben sie in der Schweiz weitgehend ausgeschlossen. Erst im Sommer 1918 versuchte der Bundesrat, sie in die Landesversorgung einzubeziehen, aber es war bereits zu spät, um die Radikalisierung des linken Zürcher Flügels aufzuhalten, die den Generalstreik auslöste. Untersucht wird schliesslich, wie die damals wütende Grippepandemie den Konflikt beeinflusste.
Published: 2022

34. The spatial relationship between the MRI lesion and intraoperative electrocorticography in focal epilepsy surgery

Author: Projectafdeling FNE, Team Innovatie Research MTKF, Other research (not in main researchprogram), MS Radiologie, Brain, Cancer, Circulatory Health, Neurochirurgen, Neurologie, Straumann, Sven, Schaft, Eline, Noordmans, Herke Jan, Dankbaar, Jan Willem, Otte, Willem M, van Steenis, Josee, Smits, Paul, Zweiphenning, Willemiek, van Eijsden, Pieter, Gebbink, Tineke, Mariani, Luigi, Van't Klooster, Maryse A, Zijlmans, Maeike, Projectafdeling FNE, Team Innovatie Research MTKF, Other research (not in main researchprogram), MS Radiologie, Brain, Cancer, Circulatory Health, Neurochirurgen, Neurologie, Straumann, Sven, Schaft, Eline, Noordmans, Herke Jan, Dankbaar, Jan Willem, Otte, Willem M, van Steenis, Josee, Smits, Paul, Zweiphenning, Willemiek, van Eijsden, Pieter, Gebbink, Tineke, Mariani, Luigi, Van't Klooster, Maryse A, and Zijlmans, Maeike
Published: 2022

35. Schulden in der Literatur: Mit Charles Dickens im Schuldgefängnis

Author: Straumann, Barbara and Straumann, Barbara
Abstract: Schulden sind eine produktive Denkfigur in der Literatur. Die literarische Sprache macht deutlich, dass finanzielle Schulden nicht die einzige Form von Schulden sind und lädt dazu ein, das Verhältnis von Schuld und Schulden auf immer wieder andere Weise durchzuspielen.
Published: 2022

36. The limits of internal devaluation: Switzerland during the Great Depression

Author: Rosenkranz, Peter, Straumann, Tobias, Woitek, Ulrich; https://orcid.org/0000-0001-5391-1199, Rosenkranz, Peter, Straumann, Tobias, and Woitek, Ulrich; https://orcid.org/0000-0001-5391-1199
Abstract: During the Great Depression, countries endowed with abundant gold reserves were not able to leave the gold standard and devalue their currencies until the mid-1930s. Instead, they were forced to go down the road of internal devaluation. We analyze the policies of the Swiss authorities by estimating a New Keynesian small open economy model. Our results show that the long adherence to the gold standard and the failure of internal devaluation imposed considerable costs on the Swiss economy. Moreover, counterfactual exercises suggest that a timely devaluation would have led to an early recovery from the Great Depression.
Published: 2022

37. Close follow-up is associated with fewer stricture formation and results in earlier detection of histological relapse in the long-term management of eosinophilic esophagitis

Author: Bon, Lorenz, Safroneeva, Ekaterina, Bussmann, Christian, Biedermann, Luc, Schreiner, Philipp; https://orcid.org/0000-0003-1610-1925, Vavricka, Stephan R, Schoepfer, Alain M, McCright-Gill, Talaya, Simon, Hans-Uwe, Straumann, Alex, Chehade, Mirna, Greuter, Thomas; https://orcid.org/0000-0003-2065-3925, Bon, Lorenz, Safroneeva, Ekaterina, Bussmann, Christian, Biedermann, Luc, Schreiner, Philipp; https://orcid.org/0000-0003-1610-1925, Vavricka, Stephan R, Schoepfer, Alain M, McCright-Gill, Talaya, Simon, Hans-Uwe, Straumann, Alex, Chehade, Mirna, and Greuter, Thomas; https://orcid.org/0000-0003-2065-3925
Abstract: BACKGROUND AND AIMS No recommendations exist regarding optimal follow-up schedule in patients with eosinophilic esophagitis (EoE) under maintenance treatment. METHODS We retrospectively evaluated a long-term surveillance concept at the Swiss EoE clinic, where clinical, endoscopic and histological disease activity is assessed annually regardless of EoE symptoms. Data on 159 adult patients under maintenance steroid treatment with available follow-up were analyzed. Patients were classified as having close (duration between visits <18 months) or non-close follow-up (≥18 months). RESULTS We analyzed a total of 309 follow-up visits of 159 patients (123 males, age at diagnosis 38.9 ± 15.4 years). 157 (51%) visits were within a close follow-up schedule (median duration between visits of 1.0 years (interquartile range (IQR) 0.9-1.2)), while 152 visits (49%) were not (median duration between visits 2.9 years (IQR 2.0-4.1)). There was no difference regarding ongoing clinical, endoscopic, and histological disease activity, and adherence to prescribed steroid treatment between the two groups. However, stricture formation was significantly less frequently observed at visits within a close follow-up schedule (22.9 vs. 33.6%, p = 0.038). Absence of close follow-up was a significant risk factor for stricture development in a multivariate regression model. Patients who achieved histological remission and were followed within a close-follow-up schedule had significantly earlier detection of histological relapse compared to patients not within such close follow-up. CONCLUSION Close follow-up is associated with fewer stricture formation and appears to result in earlier detection of histological relapse in patients with eosinophilic esophagitis. We advocate for regular assessment of disease activity (every 12-18 months) in order to detect relapsing disease as early as possible, and therefore potentially minimize the risk for EoE complications.
Published: 2022

38. Budesonide orodispersible tablets for induction of remission in patients with active eosinophilic oesophagitis: A 6-week open-label trial of the EOS-2 Programme

Author: Miehlke, Stephan; https://orcid.org/0000-0002-9174-8270, Schlag, Christoph, Lucendo, Alfredo J; https://orcid.org/0000-0003-1183-1072, Biedermann, Luc, Vaquero, Cecilio Santander; https://orcid.org/0000-0001-5492-2535, Schmoecker, Christoph, Hayat, Jamal, Hruz, Petr, Ciriza de Los Rios, Constanza, Bredenoord, Albert Jan, Vieth, Michael, Schoepfer, Alain, Attwood, Stephen, Mueller, Ralph; https://orcid.org/0000-0002-3029-8843, Burrack, Sarah, Greinwald, Roland, Straumann, Alex, Miehlke, Stephan; https://orcid.org/0000-0002-9174-8270, Schlag, Christoph, Lucendo, Alfredo J; https://orcid.org/0000-0003-1183-1072, Biedermann, Luc, Vaquero, Cecilio Santander; https://orcid.org/0000-0001-5492-2535, Schmoecker, Christoph, Hayat, Jamal, Hruz, Petr, Ciriza de Los Rios, Constanza, Bredenoord, Albert Jan, Vieth, Michael, Schoepfer, Alain, Attwood, Stephen, Mueller, Ralph; https://orcid.org/0000-0002-3029-8843, Burrack, Sarah, Greinwald, Roland, and Straumann, Alex
Abstract: BACKGROUND A novel budesonide orodispersible tablet (BOT) has been proven effective in adult patients with active eosinophilic oesophagitis (EoE) in a 6-week placebo-controlled trial (EOS-1). AIMS To report the efficacy of an open-label induction treatment with BOT in a large prospective cohort of EoE patients within the EOS-2 study. METHODS Patients with clinico-histological active EoE were treated with BOT 1 mg BID for 6 weeks. The primary endpoint was clinico-histological remission (≤2 points on numerical rating scales [0-10] each for dysphagia and odynophagia, and peak eosinophil count <16 eos/mm$^{2}$ hpf (corresponds to <5 eos/hpf)). Further study endpoints included clinical and histological remission rates, change in the EEsAI-PRO score, change in peak eosinophil counts, and deep endoscopic remission using a modified Endoscopic Reference Score. RESULTS Among 181 patients enrolled, 126 (69.6%) achieved clinico-histological remission (histological remission 90.1%, clinical remission 75.1%). The mean peak eosinophil counts decreased by 283 eos/mm$^{2}$ hpf (i.e., by 89.0%). Mean EEsAI-PRO score decreased from baseline by 29 points and deep endoscopic remission was achieved in 97 (53.6%) patients. The majority of patients judged tolerability as good or very good (85.6%) and compliance was high (96.5%). Local candidiasis was suspected in 8.3% of patients; all were of mild severity, resolved with treatment and none led to premature withdrawal from the study. CONCLUSIONS In this large prospective trial, a 6-week open-label treatment with BOT 1 mg BID was highly effective and safe in achieving clinico-histological remission of active EoE and confirmed the results of the placebo-controlled EOS-1 trial.
Published: 2022

39. Roman rights talk: subjective rights in Cicero and Livy

Author: Edelstein, Dan, Straumann, Benjamin; https://orcid.org/0000-0003-4115-7496, Edelstein, Dan, and Straumann, Benjamin; https://orcid.org/0000-0003-4115-7496
Abstract: While most scholars today recognize that Roman writers occasionally used ius to denote a subjective right, the extent and reasons for this usage have not been well studied. In this article, we offer an analysis, based on a statistical survey, of how Cicero and Livy used ius to designate a range of subjective rights. We also trace this usage back to the basic Ciceronian metaphor of the populus as a kind of societas . Rights, in the Roman context, emerged out of this legal-commercial comparison, in which citizens (or even members of different nations) are entitled to equal rights in their common venture.
Published: 2022

40. Dizziness and benign paroxysmal positional vertigo among retirement home residents: a cross-sectional descriptive and interventional study

Author: Müller, Rainer, Zangger, Peter, Straumann, Dominik; https://orcid.org/0000-0002-5349-7650, Bögli, Stefan Yu; https://orcid.org/0000-0001-5386-0811, Müller, Rainer, Zangger, Peter, Straumann, Dominik; https://orcid.org/0000-0002-5349-7650, and Bögli, Stefan Yu; https://orcid.org/0000-0001-5386-0811
Abstract: BACKGROUND The prevalence of dizziness increases with age. We aimed to determine the point prevalence of dizziness and, in particular, of benign paroxysmal positional vertigo (BPPV) among retirement home residents. Furthermore, we aimed to evaluate the efficacy of a 2-axis turntable based BPPV treatment. METHODS We contacted all large retirement homes in or around the city of Zurich (Switzerland). 10 retirement homes (with a total of 536 residents) agreed to participate in this study. 83 rejected inquiries by residents led to a potential study population of 453 residents. After a structured interview evaluating the presence and characteristics of dizziness, all willing patients were tested for positional vertigo and nystagmus on a portable and manually operated 2-axis turntable that was transported to the retirement home. Testing consisted of the Dix-Hallpike and supine roll maneuvers to both sides. Participants were immediately treated with the appropriate liberation maneuver whenever BPPV was diagnosed. Otherwise, taking the resident's medical history, a neuro-otological bedside examination, and a review of the available medical documentation was used to identify other causes of dizziness. RESULTS Out of the 453 residents, 75 (16.6%; average age: 87.0 years; 68% female) were suffering from dizziness presently or in the recent past and gave their consent to participate in this study. Among the participants tested on the turntable (n = 71), BPPV was present in 11.3% (point prevalence). Time-related properties, triggering factors and qualitative attributes of vertigo or dizziness were not significantly different between the dizzy participants with and those without BPPV. In all BPPV patients, appropriate liberation maneuvers were successful. CONCLUSIONS BPPV could be demonstrated in about one tenth of retirement home residents with dizziness or recent dizziness. Such point prevalence of BPPV translates to a much higher yearly prevalence if one assumes that BPPV is no
Published: 2022

41. A non-invasive biomechanical model of mild TBI in larval zebrafish

Author: Beppi, Carolina; https://orcid.org/0000-0002-1614-2084, Penner, Marco, Straumann, Dominik; https://orcid.org/0000-0002-5349-7650, Bögli, Stefan Yu; https://orcid.org/0000-0001-5386-0811, Beppi, Carolina; https://orcid.org/0000-0002-1614-2084, Penner, Marco, Straumann, Dominik; https://orcid.org/0000-0002-5349-7650, and Bögli, Stefan Yu; https://orcid.org/0000-0001-5386-0811
Abstract: A mild traumatic brain injury is a neurological dysfunction caused by biomechanical forces transmitted to the brain in physical impacts. The current understanding of the neuropathological cascade resulting in the manifested clinical signs and symptoms is limited due to the absence of sensitive brain imaging methods. Zebrafish are established models for the reproduction and study of neurobiological pathologies. However, all available models mostly recreate moderate-to-severe focal injuries in adult zebrafish. The present work has induced a mild brain trauma in larval zebrafish through a non-invasive biomechanical approach. A custom-made apparatus with a commercially available motor was employed to expose larvae to rapidly decelerating linear movements. The neurophysiological changes following concussion were assessed through behavioural quantifications of startle reflex locomotor distance and habituation metrics. Here we show that the injury was followed, within five minutes, by a transient anxiety state and CNS dysfunction manifested by increased startle responsivity with impaired startle habituation, putatively mirroring the human clinical sign of hypersensitivity to noise. Within a day after the injury, chronic effects arose, as evidenced by an overall reduced responsivity to sensory stimulation (lower amplitude and distance travelled along successive stimuli), reflecting the human post-concussive symptomatology. This study represents a step forward towards the establishment of a parsimonious (simple, less ethically concerning, yet sensitive) animal model of mild TBI. Our behavioural findings mimic aspects of acute and chronic effects of human concussion, which warrant further study at molecular, cellular and circuit levels. While our model opens wide avenues for studying the underlying cellular and molecular pathomechanisms, it also enables high-throughput testing of therapeutic interventions to accelerate post-concussive recovery.
Published: 2022

42. Prognosis of walking function in multiple sclerosis supported by gait pattern analysis

Author: Zörner, Björn; https://orcid.org/0000-0003-2246-3359, Hostettler, Pascal, Meyer, Christian; https://orcid.org/0000-0003-4722-7109, Killeen, Tim; https://orcid.org/0000-0001-8246-4957, Gut, Pauline, Linnebank, Michael, Weller, Michael; https://orcid.org/0000-0002-1748-174X, Straumann, Dominik; https://orcid.org/0000-0002-5349-7650, Filli, Linard; https://orcid.org/0000-0003-3882-2504, Zörner, Björn; https://orcid.org/0000-0003-2246-3359, Hostettler, Pascal, Meyer, Christian; https://orcid.org/0000-0003-4722-7109, Killeen, Tim; https://orcid.org/0000-0001-8246-4957, Gut, Pauline, Linnebank, Michael, Weller, Michael; https://orcid.org/0000-0002-1748-174X, Straumann, Dominik; https://orcid.org/0000-0002-5349-7650, and Filli, Linard; https://orcid.org/0000-0003-3882-2504
Abstract: BACKGROUND Walking impairment is a common and highly disabling symptom in people with MS (PwMS). Ambulatory deterioration is poorly characterized in PwMS and reliable prognosis that may guide clinical decisions is elusive. This study aimed to objectively track the progression of clinical walking performance and kinematic gait patterns in PwMS over 4 years, thereby revealing potential prognostic markers for deterioration of ambulatory function. METHODS Twenty-two PwMS (48.8 ± 9.9 years, 14 females; expanded disability status scale [EDSS]: 4.5 ± 0.9 points) with gait impairments were recruited at the University Hospital Zurich, Switzerland. Gait function was monitored over a period of 4 years using a set of standardized clinical walking tests (timed 25-foot walk [T25FW], 6 min walk test [6MWT], 12-item MS walking scale [MSWS-12]) and comprehensive 3D kinematic gait analysis. Walking decline was assessed in the full patient cohort and in patient sub-groups that were built according to MS type (relapsing-remitting [RRMS], progressive [PMS]) and subjects' pathological gait signature (cluster groups 1-3). RESULTS In the total cohort (n = 22), we found a significant worsening in the 6MWT (BL vs. 4y: -41.1 m; P = 0.0053), while the performance in the T25FW, MSWS-12 and the EDSS remained unchanged over 4 years. Subjects with PMS (n = 12) showed a significant worsening in the EDSS (BL vs. 4y: +0.6 points; P = 0.0053), which was not observed in participants with RRMS (n = 10). Whereas deterioration of clinical walking function was not different between subjects with RRMS and PMS, we identified differences in clinical walking deterioration between PwMS with varying gait pattern pathologies: Subjects with spastic-paretic gait impairments (cluster 1; n = 9) demonstrated a marked worsening in the T25FW (BL vs. 4y: +2 s; P = 0.0020) and 6MWT (BL vs. 4y: -92.9 m; P < 0.0001) which was not seen in PwMS with an ataxia-like (cluster 2; n = 8) or unstable walking pattern (cluster 3; n =
Published: 2022

43. Acute Unilateral Peripheral Vestibulopathy After COVID-19 Vaccination: Initial Experience in a Tertiary Neurotology Center

Author: Schmid, Marc Basil, Bächinger, David; https://orcid.org/0000-0002-6336-494X, Pangalu, Athina, Straumann, Dominik; https://orcid.org/0000-0002-5349-7650, Dlugaiczyk, Julia; https://orcid.org/0000-0001-7693-9127, Schmid, Marc Basil, Bächinger, David; https://orcid.org/0000-0002-6336-494X, Pangalu, Athina, Straumann, Dominik; https://orcid.org/0000-0002-5349-7650, and Dlugaiczyk, Julia; https://orcid.org/0000-0001-7693-9127
Abstract: ObjectiveThe aim of the present study was to identify patients who developed acute unilateral peripheral vestibulopathy (AUPVP) after COVID-19 vaccination.MethodsFor this single-center, retrospective study, we screened the medical records of our tertiary interdisciplinary neurotology center for patients who had presented with AUPVP within 30 days after COVID-19 vaccination (study period: 1 June−31 December 2021). The initial diagnosis of AUPVP was based on a comprehensive bedside neurotological examination. Laboratory vestibular testing (video head impulse test, cervical and ocular vestibular evoked myogenic potentials, dynamic visual acuity, subjective visual vertical, video-oculography, caloric testing) was performed 1–5 months later.ResultsTwenty-six patients were diagnosed with AUPVP within the study period. Of those, n = 8 (31%) had developed acute vestibular symptoms within 30 days after COVID-19 vaccination (mean interval: 11.9 days, SD: 4.8, range: 6–20) and were thus included in the study. The mean age of the patients (two females, six males) was 46 years (SD: 11.7). Seven patients had received the Moderna mRNA vaccine and one the Pfizer/BioNTech mRNA vaccine. All patients displayed a horizontal(-torsional) spontaneous nystagmus toward the unaffected ear and a pathological clinical head impulse test toward the affected ear on initial clinical examination. Receptor-specific laboratory vestibular testing performed 1–5 months later revealed recovery of vestibular function in two patients, and heterogeneous lesion patterns of vestibular endorgans in the remaining six patients.Discussion and ConclusionsThe present study should raise clinicians' awareness for AUPVP after COVID-19 vaccination. The relatively high fraction of such cases among our AUPVP patients may be due to a certain selection bias at a tertiary neurotology center. Patients presenting with acute vestibular symptoms should be questioned about their vaccination status and the date of the last vaccin
Published: 2022

44. Development of a core outcome set for therapeutic studies in eosinophilic esophagitis (COREOS)

Author: COREOS Collaborators, Ma, Christopher, Schoepfer, Alain M, Dellon, Evan S, Bredenoord, Albert J, Chehade, Mirna, Collins, Margaret H, Feagan, Brian G, Furuta, Glenn T, Gupta, Sandeep K, Hirano, Ikuo, Jairath, Vipul, Katzka, David A, Pai, Rish K, Rothenberg, Marc E, Straumann, Alex, Aceves, Seema S, Alexander, Jeffrey A, Arva, Nicoleta C, Atkins, Dan, Biedermann, Luc, Blanchard, Carine, Cianferoni, Antonella, Ciriza de Los Rios, Constanza, Clayton, Frederic, Davis, Carla M, de Bortoli, Nicola, Dias, Jorge A, Falk, Gary W, Genta, Robert M, et al, COREOS Collaborators, Ma, Christopher, Schoepfer, Alain M, Dellon, Evan S, Bredenoord, Albert J, Chehade, Mirna, Collins, Margaret H, Feagan, Brian G, Furuta, Glenn T, Gupta, Sandeep K, Hirano, Ikuo, Jairath, Vipul, Katzka, David A, Pai, Rish K, Rothenberg, Marc E, Straumann, Alex, Aceves, Seema S, Alexander, Jeffrey A, Arva, Nicoleta C, Atkins, Dan, Biedermann, Luc, Blanchard, Carine, Cianferoni, Antonella, Ciriza de Los Rios, Constanza, Clayton, Frederic, Davis, Carla M, de Bortoli, Nicola, Dias, Jorge A, Falk, Gary W, Genta, Robert M, and et al
Abstract: BACKGROUND End points used to determine treatment efficacy in eosinophilic esophagitis (EoE) have evolved over time. With multiple novel therapies in development for EoE, harmonization of outcomes measures will facilitate evidence synthesis and appraisal when comparing different treatments. OBJECTIVE We sought to develop a core outcome set (COS) for controlled and observational studies of pharmacologic and diet interventions in adult and pediatric patients with EoE. METHODS Candidate outcomes were generated from systematic literature reviews and patient engagement interviews and surveys. Consensus was established using an iterative Delphi process, with items voted on using a 9-point Likert scale and with feedback from other participants to allow score refinement. Consensus meetings were held to ratify the outcome domains of importance and the core outcome measures. Stakeholders were recruited internationally and included adult and pediatric gastroenterologists, allergists, dieticians, pathologists, psychologists, researchers, and methodologists. RESULTS The COS consists of 4 outcome domains for controlled and observational studies: histopathology, endoscopy, patient-reported symptoms, and EoE-specific quality of life. A total of 69 stakeholders (response rate 95.8%) prioritized 42 outcomes in a 2-round Delphi process, and the final ratification meeting generated consensus on 33 outcome measures. These included measurement of the peak eosinophil count, Eosinophilic Esophagitis Histology Scoring System, Eosinophilic Esophagitis Endoscopic Reference Score, and patient-reported measures of dysphagia and quality of life. CONCLUSIONS This interdisciplinary collaboration involving global stakeholders has produced a COS that can be applied to adult and pediatric studies of pharmacologic and diet therapies for EoE and will facilitate meaningful treatment comparisons and improve the quality of data synthesis.
Published: 2022

45. Is There a Role for Topical Swallowed Steroids upon Emergency Room Admission for Suspected Food Bolus Obstruction in Eosinophilic Esophagitis?

Author: Schreiner, Philipp; https://orcid.org/0000-0003-1610-1925, Greuter, Thomas, Tatu, Aurora, Keller, Dagmar I, Straumann, Alex, Biedermann, Luc, Schreiner, Philipp; https://orcid.org/0000-0003-1610-1925, Greuter, Thomas, Tatu, Aurora, Keller, Dagmar I, Straumann, Alex, and Biedermann, Luc
Abstract: Since most pharmacological treatments in case of esophageal food impaction (EFI) are unsuccessful, an endoscopy is usually required to resolve EFI. We present the first results of a budesonide orodispersible tablet (BOT) as a medical treatment option before endoscopy. We evaluated all patients with a suspected EFI to receive BOT before emergent endoscopy at a tertiary hospital between March 2019 and June 2020. A total of eight patients received BOT before endoscopy. Mean age was 50.1 years and 87.5% were male. In 38% (3/8) of patients the EFI resolved without endoscopic intervention. No adverse events occurred. After endoscopy, a diagnosis of EoE was established in 75%. This case series demonstrate the potential of BOT as medical rescue therapy in case of EFI.
Published: 2022

46. Vestibular performance in high-level soccer and ice hockey players: Sport-specific norm values and implications

Author: Tarnutzer, Alexander Andrea, Weber, Konrad Peter, Bockisch, Christopher J, Straumann, Dominik, Feddermann-Demont, Nina, Tarnutzer, Alexander Andrea, Weber, Konrad Peter, Bockisch, Christopher J, Straumann, Dominik, and Feddermann-Demont, Nina
Abstract: OBJECTIVES Quantitative vestibular testing in athletes after sports-related concussion (SRC) has become more popular due to accompanying injuries of the peripheral-vestibular organs that require targeted treatment. Sports-specific normative values are currently not available. Taking into account potential adaptational mechanisms, we obtained sports-specific, age- and peak-head-velocity-corrected normative values of peripheral-vestibular function and postural-stability in football (soccer, FB) and ice-hockey (IH) players. DESIGN Retrospective single-center case-control study. METHOD Pre-seasonal angular vestibulo-ocular reflex (aVOR) gains and cumulative-saccadic-amplitudes were obtained using the video-head-impulse test and performance in the balance-error-scoring-system (BESS) was recorded and compared in high-level FB-players (n = 510, 197 females) and IH-players (n = 210, males only) (age-range = 13-39y) and in healthy normals (n = 49, 22 females). Statistical analysis was performed using a generalized linear model. RESULTS aVOR-gain values were significantly higher for FB-players than for IH-players (1.07 ± 0.21 vs. 0.98 ± 0.13, p < 0.001) and controls (1.07 ± 0.21 vs. 0.97 ± 0.17, p < 0.001). Significant age-related changes in aVOR-gains were only observed for the anterior and posterior canals in the IH-players. Cumulative-saccadic-amplitudes were clearly below established cut-off values (0.73°/trial). BESS scores were significantly higher in IH-players than in FB-players (15.4 ± 5.1 vs. 11.2 ± 4.9, p < 0.001). CONCLUSIONS The significantly better performance of the FB players in the vertical aVOR-gains and the BESS compared to the IH-players could be related to sports-specific differences influencing visuo-vestibular and balance performance. Therefore, we recommend using the established normative aVOR-gain values for high-level FB-players, whereas in IH obtaining individual pre-seasonal (baseline) aVOR-gain values is proposed. Further studies should add sports
Published: 2022

47. Measurement of CP observables in the process B0 → DK *0 with two- and four-body D decays

Author: Aaij, R, Abellan Beteta, C, Adeva, B, Adinolfi, M, Aidala, C, Ajaltouni, Z, Akar, S, Albicocco, P, Albrecht, J, Alessio, F, Alexander, M, Alfonso Albero, A, Alkhazov, G, Alvarez Cartelle, P, Alves, A, Amato, S, Amhis, Y, An, L, Anderlini, L, Andreassi, G, Andreotti, M, Andrews, J, Archilli, F, Arnau Romeu, J, Artamonov, A, Artuso, M, Arzymatov, K, Aslanides, E, Atzeni, M, Audurier, B, Bachmann, S, Back, J, Baker, S, Balagura, V, Baldini, W, Baranov, A, Barlow, R, Barsuk, S, Barter, W, Bartolini, M, Baryshnikov, F, Batozskaya, V, Batsukh, B, Battig, A, Battista, V, Bay, A, Bedeschi, F, Bediaga, I, Beiter, A, Bel, L, Belavin, V, Belin, S, Beliy, N, Bellee, V, Belous, K, Belyaev, I, Bencivenni, G, Ben-Haim, E, Benson, S, Beranek, S, Berezhnoy, A, Bernet, R, Berninghoff, D, Bertholet, E, Bertolin, A, Betancourt, C, Betti, F, Bettler, M, Bezshyiko, I, Bhasin, S, Bhom, J, Bieker, M, Bifani, S, Billoir, P, Birnkraut, A, Bizzeti, A, Bjorn, M, Blago, M, Blake, T, Blanc, F, Blusk, S, Bobulska, D, Bocci, V, Boentegarcia, O, Boettcher, T, Boldyrev, A, Bondar, A, Bondar, N, Borghi, S, Borisyak, M, Borsato, M, Boubdir, M, Bowcock, T, Bozzi, C, Braun, S, Brearodriguez, A, Brodski, M, Brodzicka, J, Brossagonzalo, A, Brundu, D, Buchanan, E, Buonaura, A, Burr, C, Bursche, A, Butter, J, Buytaert, J, Byczynski, W, Cadeddu, S, Cai, H, Calabrese, R, Cali, S, Calladine, R, Calvi, M, Calvo Gomez, M, Camboni, A, Campana, P, Camporaperez, D, Capriotti, L, Carbone, A, Carboni, G, Cardinale, R, Cardini, A, Carniti, P, Carvalho Akiba, K, Casais Vidal, A, Casse, G, Cattaneo, M, Cavallero, G, Cenci, R, Chapman, M, Charles, M, Charpentier, P, Chatzikonstantinidis, G, Chefdeville, M, Chekalina, V, Chen, C, Chen, S, Chitic, S, Chobanova, V, Chrzaszcz, M, Chubykin, A, Ciambrone, P, Cid Vidal, X, Ciezarek, G, Cindolo, F, Clarke, P, Clemencic, M, Cliff, H, Closier, J, Cobbledick, J, Coco, V, Coelho, J, Cogan, J, Cogneras, E, Cojocariu, L, Collins, P, Colombo, T, Comerma-Montells, A, Contu, A, Cooke, N, Coombs, G, Coquereau, S, Corti, G, Costasobral, C, Couturier, B, Cowan, G, Craik, D, Crocombe, A, Torres, M, Currie, R, Da Silva, C, Dall'Occo, E, Dalseno, J, D'Ambrosio, C, Danilina, A, D'Argent, P, Davis, A, De Aguiar Francisco, O, De Bruyn, K, De Capua, S, De Cian, M, De Miranda, J, De Paula, L, De Serio, M, De Simone, P, de Vries, J, Dean, C, Dean, W, Decamp, D, Del Buono, L, Delaney, B, Dembinski, H, Demmer, M, Dendek, A, Denysenko, V, Derkach, D, Deschamps, O, Desse, F, Dettori, F, Dey, B, Di Canto, A, Di Nezza, P, Didenko, S, Dijkstra, H, Dordei, F, Dorigo, M, dos Reis, A, Dosil Suarez, A, Douglas, L, Dovbnya, A, Dreimanis, K, Dufour, L, Dujany, G, Durante, P, Durham, J, Dutta, D, Dzhelyadin, R, Dziewiecki, M, Dziurda, A, Dzyuba, A, Easo, S, Egede, U, Egorychev, V, Eidelman, S, Eisenhardt, S, Eitschberger, U, Ekelhof, R, Ek-In, S, Eklund, L, Ely, S, Ene, A, Escher, S, Esen, S, Evans, T, Falabella, A, Farber, C, Farley, N, Farry, S, Fazzini, D, Feo, M, Fernandez Declara, P, Fernandez Prieto, A, Ferrari, F, Ferreira Lopes, L, Ferreira Rodrigues, F, Ferreres Sole, S, Ferro-Luzzi, M, Filippov, S, Fini, R, Fiorini, M, Firlej, M, Fitzpatrick, C, Fiutowski, T, Fleuret, F, Fontana, M, Fontanelli, F, Forty, R, Franco Lima, V, Franco Sevilla, M, Frank, M, Frei, C, Fu, J, Funk, W, Gabriel, E, Gallas Torreira, A, Galli, D, Gallorini, S, Gambetta, S, Gan, Y, Gandelman, M, Gandini, P, Gao, Y, Garcia Martin, L, Garcia Pardinas, J, Garcia Plana, B, Garra Tico, J, Garrido, L, Gascon, D, Gaspar, C, Gazzoni, G, Gerick, D, Gersabeck, E, Gersabeck, M, Gershon, T, Gerstel, D, Ghez, P, Gibson, V, Gioventu, A, Girard, O, Gironella Gironell, P, Giubega, L, Gizdov, K, Gligorov, V, Gobel, C, Golubkov, D, Golutvin, A, Gomes, A, Gorelov, I, Gotti, C, Govorkova, E, Grabowski, J, Graciani Diaz, R, Granado Cardoso, L, Grauges, E, Graverini, E, Graziani, G, Grecu, A, Greim, R, Griffith, P, Grillo, L, Gruber, L, Gruberg Cazon, B, Gu, C, Gushchin, E, Guth, A, Guz, Y, Gys, T, Hadavizadeh, T, Hadjivasiliou, C, Haefeli, G, Haen, C, Haines, S, Hamilton, P, Han, Q, Han, X, Hancock, T, Hansmann-Menzemer, S, Harnew, N, Harrison, T, Hasse, C, Hatch, M, He, J, Hecker, M, Heijhoff, K, Heinicke, K, Heister, A, Hennessy, K, Henry, L, Hess, M, Heuel, J, Hicheur, A, Hidalgo Charman, R, Hill, D, Hilton, M, Hopchev, P, Hu, J, Hu, W, Huang, W, Huard, Z, Hulsbergen, W, Humair, T, Hushchyn, M, Hutchcroft, D, Hynds, D, Ibis, P, Idzik, M, Ilten, P, Inglessi, A, Inyakin, A, Ivshin, K, Jacobsson, R, Jakobsen, S, Jalocha, J, Jans, E, Jashal, B, Jawahery, A, Jiang, F, John, M, Johnson, D, Jones, C, Joram, C, Jost, B, Jurik, N, Kandybei, S, Karacson, M, Kariuki, J, Karodia, S, Kazeev, N, Kecke, M, Keizer, F, Kelsey, M, Kenzie, M, Ketel, T, Khanji, B, Kharisova, A, Khurewathanakul, C, Kim, K, Kirn, T, Kirsebom, V, Klaver, S, Klimaszewski, K, Kodassery Padmalayammadam, P, Koliiev, S, Kolpin, M, Kondybayeva, A, Konoplyannikov, A, Kopciewicz, P, Kopecna, R, Koppenburg, P, Kostiuk, I, Kot, O, Kotriakhova, S, Kozeiha, M, Kravchuk, L, Kreps, M, Kress, F, Kretzschmar, S, Krokovny, P, Krupa, W, Krzemien, W, Kucewicz, W, Kucharczyk, M, Kudryavtsev, V, Kunde, G, Kuonen, A, Kvaratskheliya, T, Lacarrere, D, Lafferty, G, Lai, A, Lancierini, D, Lane, J, Lanfranchi, G, Langenbruch, C, Latham, T, Lazzeroni, C, Le Gac, R, Lefevre, R, Leflat, A, Lemaitre, F, Leroy, O, Lesiak, T, Leverington, B, Li, H, Li, P, Li, X, Li, Y, Li, Z, Liang, X, Likhomanenko, T, Lindner, R, Lionetto, F, Lisovskyi, V, Liu, G, Liu, X, Loh, D, Loi, A, Lomba Castro, J, Longstaff, I, Lopes, J, Loustau, G, Lovell, G, Lucchesi, D, Lucio Martinez, M, Luo, Y, Lupato, A, Luppi, E, Lupton, O, Lusiani, A, Lyu, X, Machefert, F, Maciuc, F, Macko, V, Mackowiak, P, Maddrell-Mander, S, Maev, O, Maevskiy, A, Maguire, K, Maisuzenko, D, Majewski, M, Malde, S, Malecki, B, Malinin, A, Maltsev, T, Malygina, H, Manca, G, Mancinelli, G, Marangotto, D, Maratas, J, Marchand, J, Marconi, U, Marin Benito, C, Marinangeli, M, Marino, P, Marks, J, Marshall, P, Martellotti, G, Martinazzoli, L, Martinelli, M, Martinez Santos, D, Martinez Vidal, F, Massafferri, A, Materok, M, Matev, R, Mathad, A, Mathe, Z, Matiunin, V, Matteuzzi, C, Mattioli, K, Mauri, A, Maurice, E, Maurin, B, Mccann, M, Mcconnell, L, Mcnab, A, Mcnulty, R, Mead, J, Meadows, B, Meaux, C, Meinert, N, Melnychuk, D, Merk, M, Merli, A, Michielin, E, Milanes, D, Millard, E, Minard, M, Mineev, O, Minzoni, L, Mitzel, D, Modden, A, Mogini, A, Moise, R, Mombacher, T, Monroy, I, Monteil, S, Morandin, M, Morello, G, Morello, M, Moron, J, Morris, A, Mountain, R, Mu, H, Muheim, F, Mukherjee, M, Mulder, M, Muller, D, Muller, J, Muller, K, Muller, V, Murphy, C, Murray, D, Naik, P, Nakada, T, Nandakumar, R, Nandi, A, Nanut, T, Nasteva, I, Needham, M, Neri, N, Neubert, S, Neufeld, N, Newcombe, R, Nguyen, T, Nguyen-Mau, C, Nieswand, S, Niet, R, Nikitin, N, Nolte, N, Oblakowska-Mucha, A, Obraztsov, V, Ogilvy, S, O'Hanlon, D, Oldeman, R, Onderwater, C, Osborn, J, Ossowska, A, Otalora Goicochea, J, Ovsiannikova, T, Owen, P, Oyanguren, A, Pais, P, Pajero, T, Palano, A, Palutan, M, Panshin, G, Papanestis, A, Pappagallo, M, Pappalardo, L, Parker, W, Parkes, C, Passaleva, G, Pastore, A, Patel, M, Patrignani, C, Pearce, A, Pellegrino, A, Penso, G, Pepe Altarelli, M, Perazzini, S, Pereima, D, Perret, P, Pescatore, L, Petridis, K, Petrolini, A, Petrov, A, Petrucci, S, Petruzzo, M, Pietrzyk, B, Pietrzyk, G, Pikies, M, Pili, M, Pinci, D, Pinzino, J, Pisani, F, Piucci, A, Placinta, V, Playfer, S, Plews, J, Plo Casasus, M, Polci, F, Polilener, M, Poliakova, M, Poluektov, A, Polukhina, N, Polyakov, I, Polycarpo, E, Pomery, G, Ponce, S, Popov, A, Popov, D, Poslavskii, S, Price, E, Prouve, C, Pugatch, V, Puignavarro, A, Pullen, H, Punzi, G, Qian, W, Qin, J, Quagliani, R, Quintana, B, Raab, N, Rachwal, B, Rademacker, J, Rama, M, Ramos Pernas, M, Rangel, M, Ratnikov, F, Raven, G, Ravonel Salzgeber, M, Reboud, M, Redi, F, Reichert, S, Reiss, F, Remon Alepuz, C, Ren, Z, Renaudin, V, Ricciardi, S, Richards, S, Rinnert, K, Robbe, P, Robert, A, Rodrigues, A, Rodrigues, E, Rodriguez Lopez, J, Roehrken, M, Roiser, S, Rollings, A, Romanovskiy, V, Romero Vidal, A, Roth, J, Rotondo, M, Rudolph, M, Ruf, T, Ruiz Vidal, J, Saborido Silva, J, Sagidova, N, Saitta, B, Salustino Guimaraes, V, Sanchez Gras, C, Sanchez Mayordomo, C, Sanmartin Sedes, B, Santacesaria, R, Santamarina Rios, C, Santangelo, P, Santimaria, M, Santovetti, E, Sarpis, G, Sarti, A, Satriano, C, Satta, A, Saur, M, Savrina, D, Schael, S, Schellenberg, M, Schiller, M, Schindler, H, Schmelling, M, Schmelzer, T, Schmidt, B, Schneider, O, Schopper, A, Schreiner, H, Schubiger, M, Schulte, S, Schune, M, Schwemmer, R, Sciascia, B, Sciubba, A, Semennikov, A, Sepulveda, E, Sergi, A, Serra, N, Serrano, J, Sestini, L, Seuthe, A, Seyfert, P, Shapkin, M, Shears, T, Shekhtman, L, Shevchenko, V, Shmanin, E, Shupperd, J, Siddi, B, Silva Coutinho, R, Silva de Oliveira, L, Simi, G, Simone, S, Skiba, I, Skidmore, N, Skwarnicki, T, Slater, M, Smeaton, J, Smith, E, Smith, I, Smith, M, Soares, M, Soares Lavra, L, Sokoloff, M, Soler, F, Souza De Paula, B, Spaan, B, Spadaro Norella, E, Spradlin, P, Stagni, F, Stahl, M, Stahl, S, Stefko, P, Stefkova, S, Steinkamp, O, Stemmle, S, Stenyakin, O, Stepanova, M, Stevens, H, Stocchi, A, Stone, S, Stracka, S, Stramaglia, M, Straticiuc, M, Straumann, U, Strokov, S, Sun, J, Sun, L, Sun, Y, Swientek, K, Szabelski, A, Szumlak, T, Szymanski, M, Taneja, S, Tang, Z, Tekampe, T, Tellarini, G, Teubert, F, Thomas, E, Tilley, M, Tisserand, V, T'Jampens, S, Tobin, M, Tolk, S, Tomassetti, L, Tonelli, D, Tou, D, Tournefier, E, Traill, M, Tran, M, Trisovic, A, Tsaregorodtsev, A, Tuci, G, Tully, A, Tuning, N, Ukleja, A, Usachov, A, Ustyuzhanin, A, Uwer, U, Vagner, A, Vagnoni, V, Valassi, A, Valat, S, Valenti, G, van Beuzekom, M, Van Hecke, H, van Herwijnen, E, Van Hulse, C, van Tilburg, J, van Veghel, M, Vazquez Gomez, R, Vazquez Regueiro, P, Vazquez Sierra, C, Vecchi, S, Velthuis, J, Veltri, M, Venkateswaran, A, Vernet, M, Veronesi, M, Vesterinen, M, Viana Barbosa, J, Vieira, D, Vieites Diaz, M, Viemann, H, Vilasis-Cardona, X, Vitkovskiy, A, Vitti, M, Volkov, V, Vollhardt, A, Vom Bruch, D, Voneki, B, Vorobyev, A, Vorobyev, V, Voropaev, N, Waldi, R, Walsh, J, Wang, J, Wang, M, Wang, Y, Wang, Z, Ward, D, Wark, H, Watson, N, Websdale, D, Weiden, A, Weisser, C, White, D, Whitehead, M, Wilkinson, G, Wilkinson, M, Williams, I, Williams, M, Williams, T, Wilson, F, Winn, M, Wislicki, W, Witek, M, Wormser, G, Wotton, S, Wyllie, K, Xiang, Z, Xiao, D, Xie, Y, Xing, H, Xu, A, Xu, L, Xu, M, Xu, Q, Xu, Z, Yang, Z, Yao, Y, Yeomans, L, Yin, H, Yu, J, Yuan, X, Yushchenko, O, Zarebski, K, Zavertyaev, M, Zeng, M, Zhang, D, Zhang, L, Zhang, S, Zhang, W, Zhang, Y, Zhelezov, A, Zheng, Y, Zhou, X, Zhou, Y, Zhu, X, Zhukov, V, Zonneveld, J, Zucchelli, S, Aaij R., Abellan Beteta C., Adeva B., Adinolfi M., Aidala C. A., Ajaltouni Z., Akar S., Albicocco P., Albrecht J., Alessio F., Alexander M., Alfonso Albero A., Alkhazov G., Alvarez Cartelle P., Alves A. A., Amato S., Amhis Y., An L., Anderlini L., Andreassi G., Andreotti M., Andrews J. E., Archilli F., Arnau Romeu J., Artamonov A., Artuso M., Arzymatov K., Aslanides E., Atzeni M., Audurier B., Bachmann S., Back J. J., Baker S., Balagura V., Baldini W., Baranov A., Barlow R. J., Barsuk S., Barter W., Bartolini M., Baryshnikov F., Batozskaya V., Batsukh B., Battig A., Battista V., Bay A., Bedeschi F., Bediaga I., Beiter A., Bel L. J., Belavin V., Belin S., Beliy N., Bellee V., Belous K., Belyaev I., Bencivenni G., Ben-Haim E., Benson S., Beranek S., Berezhnoy A., Bernet R., Berninghoff D., Bertholet E., Bertolin A., Betancourt C., Betti F., Bettler M. O., Bezshyiko I., Bhasin S., Bhom J., Bieker M. S., Bifani S., Billoir P., Birnkraut A., Bizzeti A., Bjorn M., Blago M. P., Blake T., Blanc F., Blusk S., Bobulska D., Bocci V., BoenteGarcia O., Boettcher T., Boldyrev A., Bondar A., Bondar N., Borghi S., Borisyak M., Borsato M., Boubdir M., Bowcock T. J. V., Bozzi C., Braun S., BreaRodriguez A., Brodski M., Brodzicka J., BrossaGonzalo A., Brundu D., Buchanan E., Buonaura A., Burr C., Bursche A., Butter J. S., Buytaert J., Byczynski W., Cadeddu S., Cai H., Calabrese R., Cali S., Calladine R., Calvi M., Calvo Gomez M., Camboni A., Campana P., CamporaPerez D. H., Capriotti L., Carbone A., Carboni G., Cardinale R., Cardini A., Carniti P., Carvalho Akiba K., Casais Vidal A., Casse G., Cattaneo M., Cavallero G., Cenci R., Chapman M. G., Charles M., Charpentier P., Chatzikonstantinidis G., Chefdeville M., Chekalina V., Chen C., Chen S., Chitic S. -G., Chobanova V., Chrzaszcz M., Chubykin A., Ciambrone P., Cid Vidal X., Ciezarek G., Cindolo F., Clarke P. E. L., Clemencic M., Cliff H. V., Closier J., Cobbledick J. L., Coco V., Coelho J. A. B., Cogan J., Cogneras E., Cojocariu L., Collins P., Colombo T., Comerma-Montells A., Contu A., Cooke N., Coombs G., Coquereau S., Corti G., CostaSobral C. M., Couturier B., Cowan G. A., Craik D. C., Crocombe A., Torres M. C., Currie R., Da Silva C. L., Dall'Occo E., Dalseno J., D'Ambrosio C., Danilina A., d'Argent P., Davis A., De Aguiar Francisco O., De Bruyn K., De Capua S., De Cian M., De Miranda J. M., De Paula L., De Serio M., De Simone P., de Vries J. A., Dean C. T., Dean W., Decamp D., Del Buono L., Delaney B., Dembinski H. -P., Demmer M., Dendek A., Denysenko V., Derkach D., Deschamps O., Desse F., Dettori F., Dey B., Di Canto A., Di Nezza P., Didenko S., Dijkstra H., Dordei F., Dorigo M., dos Reis A. C., Dosil Suarez A., Douglas L., Dovbnya A., Dreimanis K., Dufour L., Dujany G., Durante P., Durham J. M., Dutta D., Dzhelyadin R., Dziewiecki M., Dziurda A., Dzyuba A., Easo S., Egede U., Egorychev V., Eidelman S., Eisenhardt S., Eitschberger U., Ekelhof R., Ek-In S., Eklund L., Ely S., Ene A., Escher S., Esen S., Evans T., Falabella A., Farber C., Farley N., Farry S., Fazzini D., Feo M., Fernandez Declara P., Fernandez Prieto A., Ferrari F., Ferreira Lopes L., Ferreira Rodrigues F., Ferreres Sole S., Ferro-Luzzi M., Filippov S., Fini R. A., Fiorini M., Firlej M., Fitzpatrick C., Fiutowski T., Fleuret F., Fontana M., Fontanelli F., Forty R., Franco Lima V., Franco Sevilla M., Frank M., Frei C., Fu J., Funk W., Gabriel E., Gallas Torreira A., Galli D., Gallorini S., Gambetta S., Gan Y., Gandelman M., Gandini P., Gao Y., Garcia Martin L. M., Garcia Pardinas J., Garcia Plana B., Garra Tico J., Garrido L., Gascon D., Gaspar C., Gazzoni G., Gerick D., Gersabeck E., Gersabeck M., Gershon T., Gerstel D., Ghez P., Gibson V., Gioventu A., Girard O. G., Gironella Gironell P., Giubega L., Gizdov K., Gligorov V. V., Gobel C., Golubkov D., Golutvin A., Gomes A., Gorelov I. V., Gotti C., Govorkova E., Grabowski J. P., Graciani Diaz R., Granado Cardoso L. A., Grauges E., Graverini E., Graziani G., Grecu A., Greim R., Griffith P., Grillo L., Gruber L., Gruberg Cazon B. R., Gu C., Gushchin E., Guth A., Guz Y., Gys T., Hadavizadeh T., Hadjivasiliou C., Haefeli G., Haen C., Haines S. C., Hamilton P. M., Han Q., Han X., Hancock T. H., Hansmann-Menzemer S., Harnew N., Harrison T., Hasse C., Hatch M., He J., Hecker M., Heijhoff K., Heinicke K., Heister A., Hennessy K., Henry L., Hess M., Heuel J., Hicheur A., Hidalgo Charman R., Hill D., Hilton M., Hopchev P. H., Hu J., Hu W., Huang W., Huard Z. C., Hulsbergen W., Humair T., Hushchyn M., Hutchcroft D., Hynds D., Ibis P., Idzik M., Ilten P., Inglessi A., Inyakin A., Ivshin K., Jacobsson R., Jakobsen S., Jalocha J., Jans E., Jashal B. K., Jawahery A., Jiang F., John M., Johnson D., Jones C. R., Joram C., Jost B., Jurik N., Kandybei S., Karacson M., Kariuki J. M., Karodia S., Kazeev N., Kecke M., Keizer F., Kelsey M., Kenzie M., Ketel T., Khanji B., Kharisova A., Khurewathanakul C., Kim K. E., Kirn T., Kirsebom V. S., Klaver S., Klimaszewski K., Kodassery Padmalayammadam P., Koliiev S., Kolpin M., Kondybayeva A., Konoplyannikov A., Kopciewicz P., Kopecna R., Koppenburg P., Kostiuk I., Kot O., Kotriakhova S., Kozeiha M., Kravchuk L., Kreps M., Kress F., Kretzschmar S., Krokovny P., Krupa W., Krzemien W., Kucewicz W., Kucharczyk M., Kudryavtsev V., Kunde G. J., Kuonen A. K., Kvaratskheliya T., Lacarrere D., Lafferty G., Lai A., Lancierini D., Lane J. J., Lanfranchi G., Langenbruch C., Latham T., Lazzeroni C., Le Gac R., Lefevre R., Leflat A., Lemaitre F., Leroy O., Lesiak T., Leverington B., Li H., Li P. -R., Li X., Li Y., Li Z., Liang X., Likhomanenko T., Lindner R., Lionetto F., Lisovskyi V., Liu G., Liu X., Loh D., Loi A., Lomba Castro J., Longstaff I., Lopes J. H., Loustau G., Lovell G. H., Lucchesi D., Lucio Martinez M., Luo Y., Lupato A., Luppi E., Lupton O., Lusiani A., Lyu X., Machefert F., Maciuc F., Macko V., Mackowiak P., Maddrell-Mander S., Maev O., Maevskiy A., Maguire K., Maisuzenko D., Majewski M. W., Malde S., Malecki B., Malinin A., Maltsev T., Malygina H., Manca G., Mancinelli G., Marangotto D., Maratas J., Marchand J. F., Marconi U., Marin Benito C., Marinangeli M., Marino P., Marks J., Marshall P. J., Martellotti G., Martinazzoli L., Martinelli M., Martinez Santos D., Martinez Vidal F., Massafferri A., Materok M., Matev R., Mathad A., Mathe Z., Matiunin V., Matteuzzi C., Mattioli K. R., Mauri A., Maurice E., Maurin B., McCann M., Mcconnell L., McNab A., McNulty R., Mead J. V., Meadows B., Meaux C., Meinert N., Melnychuk D., Merk M., Merli A., Michielin E., Milanes D. A., Millard E., Minard M. -N., Mineev O., Minzoni L., Mitzel D. S., Modden A., Mogini A., Moise R. D., Mombacher T., Monroy I. A., Monteil S., Morandin M., Morello G., Morello M. J., Moron J., Morris A. B., Mountain R., Mu H., Muheim F., Mukherjee M., Mulder M., Muller D., Muller J., Muller K., Muller V., Murphy C. H., Murray D., Naik P., Nakada T., Nandakumar R., Nandi A., Nanut T., Nasteva I., Needham M., Neri N., Neubert S., Neufeld N., Newcombe R., Nguyen T. D., Nguyen-Mau C., Nieswand S., Niet R., Nikitin N., Nolte N. S., Oblakowska-Mucha A., Obraztsov V., Ogilvy S., O'Hanlon D. P., Oldeman R., Onderwater C. J. G., Osborn J. D., Ossowska A., Otalora Goicochea J. M., Ovsiannikova T., Owen P., Oyanguren A., Pais P. R., Pajero T., Palano A., Palutan M., Panshin G., Papanestis A., Pappagallo M., Pappalardo L. 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B., Cogan J., Cogneras E., Cojocariu L., Collins P., Colombo T., Comerma-Montells A., Contu A., Cooke N., Coombs G., Coquereau S., Corti G., CostaSobral C. M., Couturier B., Cowan G. A., Craik D. C., Crocombe A., Torres M. C., Currie R., Da Silva C. L., Dall'Occo E., Dalseno J., D'Ambrosio C., Danilina A., d'Argent P., Davis A., De Aguiar Francisco O., De Bruyn K., De Capua S., De Cian M., De Miranda J. M., De Paula L., De Serio M., De Simone P., de Vries J. A., Dean C. T., Dean W., Decamp D., Del Buono L., Delaney B., Dembinski H. -P., Demmer M., Dendek A., Denysenko V., Derkach D., Deschamps O., Desse F., Dettori F., Dey B., Di Canto A., Di Nezza P., Didenko S., Dijkstra H., Dordei F., Dorigo M., dos Reis A. C., Dosil Suarez A., Douglas L., Dovbnya A., Dreimanis K., Dufour L., Dujany G., Durante P., Durham J. M., Dutta D., Dzhelyadin R., Dziewiecki M., Dziurda A., Dzyuba A., Easo S., Egede U., Egorychev V., Eidelman S., Eisenhardt S., Eitschberger U., Ekelhof R., Ek-In S., Eklund L., Ely S., Ene A., Escher S., Esen S., Evans T., Falabella A., Farber C., Farley N., Farry S., Fazzini D., Feo M., Fernandez Declara P., Fernandez Prieto A., Ferrari F., Ferreira Lopes L., Ferreira Rodrigues F., Ferreres Sole S., Ferro-Luzzi M., Filippov S., Fini R. A., Fiorini M., Firlej M., Fitzpatrick C., Fiutowski T., Fleuret F., Fontana M., Fontanelli F., Forty R., Franco Lima V., Franco Sevilla M., Frank M., Frei C., Fu J., Funk W., Gabriel E., Gallas Torreira A., Galli D., Gallorini S., Gambetta S., Gan Y., Gandelman M., Gandini P., Gao Y., Garcia Martin L. M., Garcia Pardinas J., Garcia Plana B., Garra Tico J., Garrido L., Gascon D., Gaspar C., Gazzoni G., Gerick D., Gersabeck E., Gersabeck M., Gershon T., Gerstel D., Ghez P., Gibson V., Gioventu A., Girard O. G., Gironella Gironell P., Giubega L., Gizdov K., Gligorov V. V., Gobel C., Golubkov D., Golutvin A., Gomes A., Gorelov I. V., Gotti C., Govorkova E., Grabowski J. P., Graciani Diaz R., Granado Cardoso L. A., Grauges E., Graverini E., Graziani G., Grecu A., Greim R., Griffith P., Grillo L., Gruber L., Gruberg Cazon B. R., Gu C., Gushchin E., Guth A., Guz Y., Gys T., Hadavizadeh T., Hadjivasiliou C., Haefeli G., Haen C., Haines S. C., Hamilton P. M., Han Q., Han X., Hancock T. H., Hansmann-Menzemer S., Harnew N., Harrison T., Hasse C., Hatch M., He J., Hecker M., Heijhoff K., Heinicke K., Heister A., Hennessy K., Henry L., Hess M., Heuel J., Hicheur A., Hidalgo Charman R., Hill D., Hilton M., Hopchev P. H., Hu J., Hu W., Huang W., Huard Z. C., Hulsbergen W., Humair T., Hushchyn M., Hutchcroft D., Hynds D., Ibis P., Idzik M., Ilten P., Inglessi A., Inyakin A., Ivshin K., Jacobsson R., Jakobsen S., Jalocha J., Jans E., Jashal B. K., Jawahery A., Jiang F., John M., Johnson D., Jones C. R., Joram C., Jost B., Jurik N., Kandybei S., Karacson M., Kariuki J. M., Karodia S., Kazeev N., Kecke M., Keizer F., Kelsey M., Kenzie M., Ketel T., Khanji B., Kharisova A., Khurewathanakul C., Kim K. E., Kirn T., Kirsebom V. S., Klaver S., Klimaszewski K., Kodassery Padmalayammadam P., Koliiev S., Kolpin M., Kondybayeva A., Konoplyannikov A., Kopciewicz P., Kopecna R., Koppenburg P., Kostiuk I., Kot O., Kotriakhova S., Kozeiha M., Kravchuk L., Kreps M., Kress F., Kretzschmar S., Krokovny P., Krupa W., Krzemien W., Kucewicz W., Kucharczyk M., Kudryavtsev V., Kunde G. J., Kuonen A. K., Kvaratskheliya T., Lacarrere D., Lafferty G., Lai A., Lancierini D., Lane J. J., Lanfranchi G., Langenbruch C., Latham T., Lazzeroni C., Le Gac R., Lefevre R., Leflat A., Lemaitre F., Leroy O., Lesiak T., Leverington B., Li H., Li P. -R., Li X., Li Y., Li Z., Liang X., Likhomanenko T., Lindner R., Lionetto F., Lisovskyi V., Liu G., Liu X., Loh D., Loi A., Lomba Castro J., Longstaff I., Lopes J. 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Abstract: Measurements of CP observables in B-0 -> DK0 decays are presented, where D represents a superposition of D-0 and D0 states. The D meson is reconstructed in the two-body final states K+pi(-), pi K-+(-), K+K- and pi(+)pi(-), and, for the first time, in the fourbody final states K+pi(-)pi(+)pi(-), pi K-+(-)pi(+)pi(-) and pi(+)pi(-)pi(+)pi(-). The analysis uses a sample of neutral B mesons produced in proton-proton collisions, corresponding to an integrated luminosity of 1.0, 2.0 and 1.8 fb(-1) collected with the LHCb detector at centre-of-mass energies of ,8 and 13 TeV, respectively. First observations of the decays B-0 -> D(pi K-+(-))K-0 and B-0 -> D(pi(+)pi(-)pi(+)pi(-))K-0 are obtained. The measured observables are interpreted in terms of the CP -violating weak phase gamma.
Published: 2019

48. Measurement of Charged Hadron Production in Z -Tagged Jets in Proton-Proton Collisions at s =8 TeV

Author: Aaij, R, Abellan Beteta, C, Adeva, B, Adinolfi, M, Aidala, C, Ajaltouni, Z, Akar, S, Albicocco, P, Albrecht, J, Alessio, F, Alexander, M, Alfonso Albero, A, Alkhazov, G, Alvarez Cartelle, P, Alves, A, Amato, S, Amhis, Y, An, L, Anderlini, L, Andreassi, G, Andreotti, M, Andrews, J, Archilli, F, Arnau Romeu, J, Artamonov, A, Artuso, M, Arzymatov, K, Aslanides, E, Atzeni, M, Audurier, B, Bachmann, S, Back, J, Baker, S, Balagura, V, Baldini, W, Baranov, A, Barlow, R, Barsuk, S, Barter, W, Bartolini, M, Baryshnikov, F, Batozskaya, V, Batsukh, B, Battig, A, Battista, V, Bay, A, Bedeschi, F, Bediaga, I, Beiter, A, Bel, L, Belin, S, Beliy, N, Bellee, V, Belloli, N, Belous, K, Belyaev, I, Bencivenni, G, Ben-Haim, E, Benson, S, Beranek, S, Berezhnoy, A, Bernet, R, Berninghoff, D, Bertholet, E, Bertolin, A, Betancourt, C, Betti, F, Bettler, M, Bezshyiko, I, Bhasin, S, Bhom, J, Bieker, M, Bifani, S, Billoir, P, Birnkraut, A, Bizzeti, A, Bjorn, M, Blago, M, Blake, T, Blanc, F, Blusk, S, Bobulska, D, Bocci, V, Boente Garcia, O, Boettcher, T, Bondar, A, Bondar, N, Borghi, S, Borisyak, M, Borsato, M, Boubdir, M, Bowcock, T, Bozzi, C, Braun, S, Brodski, M, Brodzicka, J, Brossa Gonzalo, A, Brundu, D, Buchanan, E, Buonaura, A, Burr, C, Bursche, A, Butter, J, Buytaert, J, Byczynski, W, Cadeddu, S, Cai, H, Calabrese, R, Cali, S, Calladine, R, Calvi, M, Calvo Gomez, M, Camboni, A, Campana, P, Campora Perez, D, Capriotti, L, Carbone, A, Carboni, G, Cardinale, R, Cardini, A, Carniti, P, Carvalho Akiba, K, Casse, G, Cattaneo, M, Cavallero, G, Cenci, R, Chapman, M, Charles, M, Charpentier, P, Chatzikonstantinidis, G, Chefdeville, M, Chekalina, V, Chen, C, Chen, S, Chitic, S, Chobanova, V, Chrzaszcz, M, Chubykin, A, Ciambrone, P, Cid Vidal, X, Ciezarek, G, Cindolo, F, Clarke, P, Clemencic, M, Cliff, H, Closier, J, Coco, V, Coelho, J, Cogan, J, Cogneras, E, Cojocariu, L, Collins, P, Colombo, T, Comerma-Montells, A, Contu, A, Coombs, G, Coquereau, S, Corti, G, Costa Sobral, C, 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Ferreres Sole, S, Ferro-Luzzi, M, Filippov, S, Fini, R, Fiorini, M, Firlej, M, Fitzpatrick, C, Fiutowski, T, Fleuret, F, Fontana, M, Fontanelli, F, Forty, R, Franco Lima, V, Frank, M, Frei, C, Fu, J, Funk, W, Gabriel, E, Gallas Torreira, A, Galli, D, Gallorini, S, Gambetta, S, Gan, Y, Gandelman, M, Gandini, P, Gao, Y, Garcia Martin, L, Garcia Pardinas, J, Garcia Plana, B, Garra Tico, J, Garrido, L, Gascon, D, Gaspar, C, Gazzoni, G, Gerick, D, Gersabeck, E, Gersabeck, M, Gershon, T, Gerstel, D, Ghez, P, Gibson, V, Girard, O, Gironella Gironell, P, Giubega, L, Gizdov, K, Gligorov, V, Gobel, C, Golubkov, D, Golutvin, A, Gomes, A, Gorelov, I, Gotti, C, Govorkova, E, Grabowski, J, Graciani Diaz, R, Granado Cardoso, L, Grauges, E, Graverini, E, Graziani, G, Grecu, A, Greim, R, Griffith, P, Grillo, L, Gruber, L, Gruberg Cazon, B, Gu, C, Gushchin, E, Guth, A, Guz, Y, Gys, T, Hadavizadeh, T, Hadjivasiliou, C, Haefeli, G, Haen, C, Haines, S, Hamilton, B, Han, Q, Han, X, Hancock, T, 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L., Parker W., Parkes C., Passaleva G., Pastore A., Patel M., Patrignani C., Pearce A., Pellegrino A., Penso G., Pepe Altarelli M., Perazzini S., Pereima D., Perret P., Pescatore L., Petridis K., Petrolini A., Petrov A., Petrucci S., Petruzzo M., Pietrzyk B., Pietrzyk G., Pikies M., Pili M., Pinci D., Pinzino J., Pisani F., Piucci A., Placinta V., Playfer S., Plews J., Plo Casasus M., Polci F., Poli Lener M., Poliakova M., Poluektov A., Polukhina N., Polyakov I., Polycarpo E., Pomery G. J., Ponce S., Popov A., Popov D., Poslavskii S., Price E., Prouve C., Pugatch V., Puig Navarro A., Pullen H., Punzi G., Qian W., Qin J., Quagliani R., Quintana B., Raab N. V., Rachwal B., Rademacker J. H., Rama M., Ramos Pernas M., Rangel M. S., Ratnikov F., Raven G., Ravonel Salzgeber M., Reboud M., Redi F., Reichert S., Reiss F., Remon Alepuz C., Ren Z., Renaudin V., Ricciardi S., Richards S., Rinnert K., Robbe P., Robert A., Rodrigues A. B., Rodrigues E., Rodriguez Lopez J. A., Roehrken M., Roiser S., Rollings A., Romanovskiy V., Romero Vidal A., Roth J. D., Rotondo M., Rudolph M. S., Ruf T., Ruiz Vidal J., Saborido Silva J. J., Sagidova N., Saitta B., Salustino Guimaraes V., Sanchez Gras C., Sanchez Mayordomo C., Sanmartin Sedes B., Santacesaria R., Santamarina Rios C., Santimaria M., Santovetti E., Sarpis G., Sarti A., Satriano C., Satta A., Saur M., Savrina D., Schael S., Schellenberg M., Schiller M., Schindler H., Schmelling M., Schmelzer T., Schmidt B., Schneider O., Schopper A., Schreiner H. F., Schubiger M., Schulte S., Schune M. H., Schwemmer R., Sciascia B., Sciubba A., Semennikov A., Sepulveda E. S., Sergi A., Serra N., Serrano J., Sestini L., Seuthe A., Seyfert P., Shapkin M., Shears T., Shekhtman L., Shevchenko V., Shmanin E., Siddi B. G., Silva Coutinho R., Silva De Oliveira L., Simi G., Simone S., Skiba I., Skidmore N., Skwarnicki T., Slater M. W., Smeaton J. G., Smith E., Smith I. T., Smith M., Soares M., Soares Lavra L., Sokoloff M. D., Soler F. J. P., Souza De Paula B., Spaan B., Spadaro Norella E., Spradlin P., Stagni F., Stahl M., Stahl S., Stefko P., Stefkova S., Steinkamp O., Stemmle S., Stenyakin O., Stepanova M., Stevens H., Stocchi A., Stone S., Stracka S., Stramaglia M. E., Straticiuc M., Straumann U., Strokov S., Sun J., Sun L., Sun Y., Swientek K., Szabelski A., Szumlak T., Szymanski M., Tang Z., Tekampe T., Tellarini G., Teubert F., Thomas E., Tilley M. J., Tisserand V., T'Jampens S., Tobin M., Tolk S., Tomassetti L., Tonelli D., Tou D. Y., Tourinho Jadallah Aoude R., Tournefier E., Traill M., Tran M. T., Trisovic A., Tsaregorodtsev A., Tuci G., Tully A., Tuning N., Ukleja A., Usachov A., Ustyuzhanin A., Uwer U., Vagner A., Vagnoni V., Valassi A., Valat S., Valenti G., Van Beuzekom M., Van Hecke H., Van Herwijnen E., Van Hulse C. B., Van Tilburg J., Van Veghel M., Vasiliev A., Vazquez Gomez R., Vazquez Regueiro P., Vazquez Sierra C., Vecchi S., Velthuis J. J., Veltri M., Venkateswaran A., Vernet M., Veronesi M., Vesterinen M., Viana Barbosa J. V., Vieira D., Vieites Diaz M., Viemann H., Vilasis-Cardona X., Vitkovskiy A., Vitti M., Volkov V., Vollhardt A., Vom Bruch D., Voneki B., Vorobyev A., Vorobyev V., Voropaev N., Waldi R., Walsh J., Wang J., Wang M., Wang Y., Wang Z., Ward D. R., Wark H. M., Watson N. K., Websdale D., Weiden A., Weisser C., Whitehead M., Wilkinson G., Wilkinson M., Williams I., Williams M., Williams M. R. J., Williams T., Wilson F. F., Winn M., Wislicki W., Witek M., Wormser G., Wotton S. A., Wyllie K., Xiao D., Xie Y., Xing H., Xu A., Xu L., Xu M., Xu Q., Xu Z., Yang Z., Yao Y., Yeomans L. E., Yin H., Yu J., Yuan X., Yushchenko O., Zarebski K. A., Zavertyaev M., Zeng M., Zhang D., Zhang L., Zhang S., Zhang W. C., Zhang Y., Zhelezov A., Zheng Y., Zhu X., Zhukov V., Zonneveld J. B., and Zucchelli S.
Abstract: The production of charged hadrons within jets recoiling against a Z boson is measured in proton-proton collision data at s=8 TeV recorded by the LHCb experiment. The charged-hadron structure of the jet is studied longitudinally and transverse to the jet axis for jets with transverse momentum pT>20 GeV and in the pseudorapidity range 2.5<4. These are the first measurements of jet hadronization at these forward rapidities and also the first where the jet is produced in association with a Z boson. In contrast to previous hadronization measurements at the Large Hadron Collider, which are dominated by gluon jets, these measurements probe predominantly light-quark jets which are found to be more longitudinally and transversely collimated with respect to the jet axis when compared to the previous gluon dominated measurements. Therefore, these results provide valuable information on differences between quarks and gluons regarding nonperturbative hadronization dynamics.
Published: 2019

49. LHCb Collaboration

Author: Bediaga, I, Cruz Torres, M, De Miranda, J, dos Reis, A, Gomes, A, Massafferri, A, Molina Rodriguez, J, Soares Lavra, L, Tourinho Jadallah Aoude, R, Amato, S, Carvalho Akiba, K, Da Cunha Marinho, F, De Paula, L, Ferreira Rodrigues, F, Gandelman, M, Hicheur, A, Lopes, J, Nasteva, I, Otalora Goicochea, J, Polycarpo, E, Potterat, C, Rangel, M, Silva de Oliveira, L, Souza De Paula, B, An, L, Chen, C, Davis, A, Gan, Y, Gao, Y, Gu, C, Jiang, F, Li, T, Liu, X, Ren, Z, Sun, J, Tang, Z, Wang, M, Xu, A, Xu, Z, Yang, Z, Zhang, L, Zhang, W, Zhu, X, Chefdeville, M, Decamp, D, Ghez, P, Marchand, J, Minard, M, Pietrzyk, B, Reboud, M, T'Jampens, S, Tournefier, E, Ajaltouni, Z, Cogneras, E, Deschamps, O, Gazzoni, G, Hadjivasiliou, C, Kozeiha, M, Lefevre, R, Maratas, J, Monteil, S, Perret, P, Quintana, B, Tisserand, V, Vernet, M, Arnau Romeu, J, Aslanides, E, Cogan, J, Gerstel, D, Le Gac, R, Leroy, O, Mancinelli, G, Martin, M, Meaux, C, Morris, A, Serrano, J, Tayduganov, A, Tsaregorodtsev, A, Amhis, Y, Balagura, V, Barsuk, S, Bossu, F, Chamont, D, Coelho, J, Desse, F, Fleuret, F, Lefrancois, J, Lisovskyi, V, Machefert, F, Marin Benito, C, Maurice, E, Renaudin, V, Robbe, P, Schune, M, Stocchi, A, Usachov, A, Winn, M, Wormser, G, Zhang, Y, Ben-Haim, E, Bertholet, E, Billoir, P, Charles, M, Del Buono, L, Dujany, G, Gligorov, V, Mogini, A, Polci, F, Quagliani, R, Reiss, F, Robert, A, Sepulveda, E, Tou, D, Beranek, S, Boubdir, M, Escher, S, Kirn, T, Langenbruch, C, Materok, M, Nieswand, S, Schael, S, Smith, E, Verlage, T, Whitehead, M, Zhukov, V, Albrecht, J, Birnkraut, A, Demmer, M, Eitschberger, U, Ekelhof, R, Gavardi, L, Heinicke, K, Heister, A, Ibis, P, Mackowiak, P, Meier, F, Modden, A, Mombacher, T, Muller, J, Muller, V, Niet, R, Reichert, S, Schellenberg, M, Schmelzer, T, Seuthe, A, Spaan, B, Stevens, H, Tekampe, T, Wishahi, J, Dembinski, H, Klimkovich, T, Schmelling, M, Zavertyaev, M, Bachmann, S, Berninghoff, D, Braun, S, Comerma-Montells, A, D'Argent, P, Dziewiecki, M, Gerick, D, Grabowski, J, Han, X, Hansmann-Menzemer, S, Kecke, M, Khanji, B, Kolpin, M, Kopecna, R, Leverington, B, Marks, J, Mitzel, D, Neubert, S, Neuner, M, Piucci, A, Skidmore, N, Stahl, M, Stemmle, S, Uwer, U, Zhelezov, A, Mcnulty, R, Veronika, N, De Serio, M, Fini, R, Palano, A, Pastore, A, Simone, S, Betti, F, Carbone, A, Falabella, A, Ferrari, F, Galli, D, Marconi, U, O'Hanlon, D, Patrignani, C, Soares, M, Vagnoni, V, Valenti, G, Zucchelli, S, Andreotti, M, Baldini, W, Bozzi, C, Calabrese, R, Corvo, M, Fiorini, M, Luppi, E, Minzoni, L, Pappalardo, L, Siddi, B, Tellarini, G, Tomassetti, L, Vecchi, S, Anderlini, L, Bizzeti, A, Graziani, G, Passaleva, G, Veltri, M, Albicocco, P, Bencivenni, G, Campana, P, Ciambrone, P, De Simone, P, Di Nezza, P, Klaver, S, Lanfranchi, G, Morello, G, Ogilvy, S, Palutan, M, Poli Lener, M, Rotondo, M, Santimaria, M, Sarti, A, Sciascia, B, Cardinale, R, Cavallero, G, Fontanelli, F, Petrolini, A, Belloli, N, Calvi, M, Carniti, P, Cassina, L, Fazzini, D, Gotti, C, Matteuzzi, C, Fu, J, Gandini, P, Marangotto, D, Merli, A, Neri, N, Petruzzo, M, Audurier, B, Brundu, D, Bursche, A, Cadeddu, S, Cardini, A, Chen, S, Contu, A, Fontana, M, Griffith, P, Lai, A, Loi, A, Manca, G, Oldeman, R, Saitta, B, Amerio, S, Bertolin, A, Gallorini, S, Lucchesi, D, Lupato, A, Michielin, E, Morandin, M, Sestini, L, Simi, G, Bedeschi, F, Cenci, R, Lusiani, A, Morello, M, Pajero, T, Punzi, G, Rama, M, Stracka, S, Tonelli, D, Tuci, G, Walsh, J, Carboni, G, Federici, L, Santovetti, E, Satta, A, Bocci, V, Martellotti, G, Penso, G, Pinci, D, Santacesaria, R, Satriano, C, Sciubba, A, Aaij, R, Ali, S, Archilli, F, Bel, L, Benson, S, Dall'Occo, E, de Vries, J, Dufour, L, Esen, S, Feo Pereira Rivello Carvalho, M, Govorkova, E, Greim, R, Hulsbergen, W, Hynds, D, Jans, E, Koppenburg, P, Kostiuk, I, Merk, M, Mulder, M, Pellegrino, A, Sanchez Gras, C, Tuning, N, van Beuzekom, M, van Tilburg, J, van Veghel, M, Vazquez Sierra, C, Veronesi, M, Vitkovskiy, A, Ketel, T, Raven, G, Syropoulos, V, Bhom, J, Brodzicka, J, Dziurda, A, Kucewicz, W, Kucharczyk, M, Lesiak, T, Malecki, B, Ossowska, A, Pikies, M, Witek, M, Dendek, A, Firlej, M, Fiutowski, T, Idzik, M, Krupa, W, Majewski, M, Moron, J, Oblakowska-Mucha, A, Rachwal, B, Swientek, K, Szumlak, T, Tobin, M, Batozskaya, V, Klimaszewski, K, Krzemien, W, Melnychuk, D, Ukleja, A, Wislicki, W, Cojocariu, L, Ene, A, Giubega, L, Grecu, A, Maciuc, F, Placinta, V, Straticiuc, M, Alkhazov, G, Bondar, N, Chubykin, A, Dzyuba, A, Ivshin, K, Kotriakhova, S, Maev, O, Maisuzenko, D, Sagidova, N, Shcheglov, Y, Stepanova, M, Vorobyev, A, Belyaev, I, Danilina, A, Egorychev, V, Golubkov, D, Kvaratskheliya, T, Pereima, D, Savrina, D, Semennikov, A, Berezhnoy, A, Gorelov, I, Leflat, A, Nikitin, N, Volkov, V, Filippov, S, Gushchin, E, Kravchuk, L, Arzymatov, K, Baranov, A, Borisyak, M, Chekalina, V, Derkach, D, Hushchyn, M, Kazeev, N, Khairullin, E, Ratnikov, F, Rogozhnikov, A, Ustyuzhanin, A, Bondar, A, Eidelman, S, Krokovny, P, Kudryavtsev, V, Maltsev, T, Shekhtman, L, Vorobyev, V, Artamonov, A, Belous, K, Dzhelyadin, R, Guz, Y, Obraztsov, V, Popov, A, Poslavskii, S, Romanovskiy, V, Shapkin, M, Stenyakin, O, Yushchenko, O, Alfonso Albero, A, Calvo Gomez, M, Camboni, A, Coquereau, S, Garrido, L, Gascon, D, Graciani Diaz, R, Grauges, E, Vilasis-Cardona, X, Adeva, B, Alves, A, Boente Garcia, O, Borsato, M, Chobanova, V, Cid Vidal, X, Dosil Suarez, A, Fernandez Prieto, A, Gallas Torreira, A, Garcia Plana, B, Lucio Martinez, M, Martinez Santos, D, Plo Casasus, M, Prisciandaro, J, Ramos Pernas, M, Romero Vidal, A, Saborido Silva, J, Sanmartin Sedes, B, Santamarina Rios, C, Vazquez Regueiro, P, Vieites Diaz, M, Alessio, F, Blago, M, Brodski, M, Buytaert, J, Byczynski, W, Campora Perez, D, Cattaneo, M, Charpentier, P, Chitic, S, Chrzaszcz, M, Ciezarek, G, Clemencic, M, Closier, J, Coco, V, Collins, P, Colombo, T, Coombs, G, Corti, G, Couturier, B, D'Ambrosio, C, De Aguiar Francisco, O, De Bruyn, K, Di Canto, A, Dijkstra, H, Dordei, F, Dorigo, M, Durante, P, Farber, C, Fernandez Declara, P, Ferro-Luzzi, M, Forty, R, Frank, M, Frei, C, Funk, W, Gaspar, C, Granado Cardoso, L, Gruber, L, Gys, T, Haen, C, Hasse, C, Hatch, M, Jacobsson, R, Johnson, D, Joram, C, Jost, B, Karacson, M, Lacarrere, D, Lemaitre, F, Lindner, R, Lupton, O, Martinelli, M, Matev, R, Mathe, Z, Muller, D, Neufeld, N, Nolte, N, Pearce, A, Pepe Altarelli, M, Perazzini, S, Pinzino, J, Pisani, F, Ponce, S, Ravonel Salzgeber, M, Roehrken, M, Roiser, S, Ruf, T, Schindler, H, Schmidt, B, Schopper, A, Schwemmer, R, Seyfert, P, Stagni, F, Stahl, S, Teubert, F, Thomas, E, Tolk, S, Valassi, A, Valat, S, van Herwijnen, E, Vazquez Gomez, R, Viana Barbosa, J, Voneki, B, Wyllie, K, Andreassi, G, Battista, V, Bay, A, Bellee, V, Blanc, F, De Cian, M, Ferreira Lopes, L, Fitzpatrick, C, Giani, S, Girard, O, Haefeli, G, Hopchev, P, Khurewathanakul, C, Kuonen, A, Macko, V, Marinangeli, M, Marino, P, Maurin, B, Nakada, T, Nanut, T, Nguyen, T, Nguyen-Mau, C, Pais, P, Pescatore, L, Pietrzyk, G, Redi, F, Rodrigues, A, Schneider, O, Schubiger, M, Stefko, P, Stramaglia, M, Tran, M, Atzeni, M, Bernet, R, Betancourt, C, Bezshyiko, I, Buonaura, A, Garcia Pardinas, J, Graverini, E, Lancierini, D, Lionetto, F, Mauri, A, Muller, K, Owen, P, Puig Navarro, A, Serra, N, Silva Coutinho, R, Steinkamp, O, Storaci, B, Straumann, U, Vollhardt, A, Wang, Z, Weiden, A, Dovbnya, A, Kandybei, S, Koliiev, S, Pugatch, V, Bifani, S, Calladine, R, Chatzikonstantinidis, G, Farley, N, Ilten, P, Lazzeroni, C, Mazurov, A, Plews, J, Popov, D, Sergi, A, Watson, N, Williams, T, Zarebski, K, Adinolfi, M, Bhasin, S, Buchanan, E, Chapman, M, Dalseno, J, Harnew, S, Kariuki, J, Maddrell-Mander, S, Naik, P, Petridis, K, Pomery, G, Price, E, Prouve, C, Rademacker, J, Richards, S, Velthuis, J, Bettler, M, Cliff, H, Delaney, B, Garra Tico, J, Gibson, V, Haines, S, Jones, C, Keizer, F, Kenzie, M, Lovell, G, Smeaton, J, Trisovic, A, Tully, A, Vitti, M, Ward, D, Williams, I, Wotton, S, Back, J, Blake, T, Brossa Gonzalo, A, Costa Sobral, C, Crocombe, A, Gershon, T, Kreps, M, Latham, T, Loh, D, Mathad, A, Millard, E, Poluektov, A, Wicht, J, Easo, S, Nandakumar, R, Papanestis, A, Ricciardi, S, Wilson, F, Carson, L, Clarke, P, Cowan, G, Currie, R, Eisenhardt, S, Gabriel, E, Gambetta, S, Gizdov, K, Muheim, F, Needham, M, Pappagallo, M, Petrucci, S, Playfer, S, Smith, I, Zonneveld, J, Alexander, M, Beddow, J, Bobulska, D, Dean, C, Douglas, L, Eklund, L, Karodia, S, Longstaff, I, Schiller, M, Soler, F, Spradlin, P, Traill, M, Bowcock, T, Casse, G, Dettori, F, Dreimanis, K, Farry, S, Franco Lima, V, Harrison, T, Hennessy, K, Hutchcroft, D, Marshall, P, Mead, J, Rinnert, K, Shears, T, Wark, H, Yeomans, L, Alvarez Cartelle, P, Baker, S, Egede, U, Golutvin, A, Hecker, M, Humair, T, Kress, F, Mccann, M, Patel, M, Smith, M, Stefkova, S, Tilley, M, Websdale, D, Appleby, R, Barlow, R, Barter, W, Borghi, S, Burr, C, Capriotti, L, De Capua, S, Dutta, D, Gersabeck, E, Gersabeck, M, Grillo, L, Hidalgo Charman, R, Hilton, M, Lafferty, G, Maguire, K, Mcnab, A, Murray, D, Parkes, C, Sarpis, G, Williams, M, Bjorn, M, Gruberg Cazon, B, Hadavizadeh, T, Hancock, T, Harnew, N, Hill, D, Jalocha, J, John, M, Jurik, N, Malde, S, Murphy, C, Nandi, A, Pili, M, Pullen, H, Rollings, A, Veneziano, G, Vesterinen, M, Wilkinson, G, Boettcher, T, Craik, D, Weisser, C, Akar, S, Evans, T, Huard, Z, Meadows, B, Rodrigues, E, Schreiner, H, Sokoloff, M, Andrews, J, Hamilton, B, Jawahery, A, Parker, W, Wimberley, J, Artuso, M, Batsukh, B, Beiter, A, Blusk, S, Ely, S, Kelsey, M, Kim, K, Li, Z, Liang, X, Mountain, R, Polyakov, I, Rudolph, M, Skwarnicki, T, Stone, S, Venkateswaran, A, Wang, J, Wilkinson, M, Yao, Y, Yuan, X, Gobel, C, Salustino Guimaraes, V, Beliy, N, He, J, Huang, W, Li, P, Lyu, X, Qian, W, Qin, J, Saur, M, Szymanski, M, Vieira, D, Xu, Q, Zheng, Y, Cai, H, Sun, L, Dey, B, Hu, W, Wang, Y, Xiao, D, Xie, Y, Xu, M, Yin, H, Yu, J, Zhang, D, Milanes, D, Monroy, I, Rodriguez Lopez, J, Grunberg, O, Hess, M, Meinert, N, Viemann, H, Waldi, R, Onderwater, C, Likhomanenko, T, Malinin, A, Morgunova, O, Nogay, A, Petrov, A, Shevchenko, V, Baryshnikov, F, Didenko, S, Polukhina, N, Shmanin, E, Panshin, G, Strokov, S, Vagner, A, Garcia Martin, L, Henry, L, Martinez Vidal, F, Oyanguren, A, Remon Alepuz, C, Ruiz Vidal, J, Sanchez Mayordomo, C, Aidala, C, Da Silva, C, Durham, J, Bediaga I., Cruz Torres M., De Miranda J. M., dos Reis A. C., Gomes A., Massafferri A., Molina Rodriguez J., Soares Lavra L., Tourinho Jadallah Aoude R., Amato S., Carvalho Akiba K., Da Cunha Marinho F., De Paula L., Ferreira Rodrigues F., Gandelman M., Hicheur A., Lopes J. H., Nasteva I., Otalora Goicochea J. M., Polycarpo E., Potterat C., Rangel M. S., Silva de Oliveira L., Souza De Paula B., An L., Chen C., Davis A., Gan Y., Gao Y., Gu C., Jiang F., Li T., Liu X., Ren Z., Sun J., Tang Z., Wang M., Xu A., Xu Z., Yang Z., Zhang L., Zhang W. C., Zhu X., Chefdeville M., Decamp D., Ghez P., Marchand J. F., Minard M. -N., Pietrzyk B., Reboud M., T'Jampens S., Tournefier E., Ajaltouni Z., Cogneras E., Deschamps O., Gazzoni G., Hadjivasiliou C., Kozeiha M., Lefevre R., Maratas J., Monteil S., Perret P., Quintana B., Tisserand V., Vernet M., Arnau Romeu J., Aslanides E., Cogan J., Gerstel D., Le Gac R., Leroy O., Mancinelli G., Martin M., Meaux C., Morris A. B., Serrano J., Tayduganov A., Tsaregorodtsev A., Amhis Y., Balagura V., Barsuk S., Bossu F., Chamont D., Coelho J. A. B., Desse F., Fleuret F., Lefrancois J., Lisovskyi V., Machefert F., Marin Benito C., Maurice E., Renaudin V., Robbe P., Schune M. H., Stocchi A., Usachov A., Winn M., Wormser G., Zhang Y., Ben-Haim E., Bertholet E., Billoir P., Charles M., Del Buono L., Dujany G., Gligorov V. V., Mogini A., Polci F., Quagliani R., Reiss F., Robert A., Sepulveda E. S., Tou D. Y., Beranek S., Boubdir M., Escher S., Kirn T., Langenbruch C., Materok M., Nieswand S., Schael S., Smith E., Verlage T. A., Whitehead M., Zhukov V., Albrecht J., Birnkraut A., Demmer M., Eitschberger U., Ekelhof R., Gavardi L., Heinicke K., Heister A., Ibis P., Mackowiak P., Meier F., Modden A., Mombacher T., Muller J., Muller V., Niet R., Reichert S., Schellenberg M., Schmelzer T., Seuthe A., Spaan B., Stevens H., Tekampe T., Wishahi J., Dembinski H. -P., Klimkovich T., Schmelling M., Zavertyaev M., Bachmann S., Berninghoff D., Braun S., Comerma-Montells A., d'Argent P., Dziewiecki M., Gerick D., Grabowski J. P., Han X., Hansmann-Menzemer S., Kecke M., Khanji B., Kolpin M., Kopecna R., Leverington B., Marks J., Mitzel D. S., Neubert S., Neuner M., Piucci A., Skidmore N., Stahl M., Stemmle S., Uwer U., Zhelezov A., McNulty R., Veronika N. V., De Serio M., Fini R. A., Palano A., Pastore A., Simone S., Betti F., Carbone A., Falabella A., Ferrari F., Galli D., Marconi U., O'Hanlon D. P., Patrignani C., Soares M., Vagnoni V., Valenti G., Zucchelli S., Andreotti M., Baldini W., Bozzi C., Calabrese R., Corvo M., Fiorini M., Luppi E., Minzoni L., Pappalardo L. L., Siddi B. G., Tellarini G., Tomassetti L., Vecchi S., Anderlini L., Bizzeti A., Graziani G., Passaleva G., Veltri M., Albicocco P., Bencivenni G., Campana P., Ciambrone P., De Simone P., Di Nezza P., Klaver S., Lanfranchi G., Morello G., Ogilvy S., Palutan M., Poli Lener M., Rotondo M., Santimaria M., Sarti A., Sciascia B., Cardinale R., Cavallero G., Fontanelli F., Petrolini A., Belloli N., Calvi M., Carniti P., Cassina L., Fazzini D., Gotti C., Matteuzzi C., Fu J., Gandini P., Marangotto D., Merli A., Neri N., Petruzzo M., Audurier B., Brundu D., Bursche A., Cadeddu S., Cardini A., Chen S., Contu A., Fontana M., Griffith P., Lai A., Loi A., Manca G., Oldeman R., Saitta B., Amerio S., Bertolin A., Gallorini S., Lucchesi D., Lupato A., Michielin E., Morandin M., Sestini L., Simi G., Bedeschi F., Cenci R., Lusiani A., Morello M. J., Pajero T., Punzi G., Rama M., Stracka S., Tonelli D., Tuci G., Walsh J., Carboni G., Federici L., Santovetti E., Satta A., Bocci V., Martellotti G., Penso G., Pinci D., Santacesaria R., Satriano C., Sciubba A., Aaij R., Ali S., Archilli F., Bel L. J., Benson S., Dall'Occo E., de Vries J. A., Dufour L., Esen S., Feo Pereira Rivello Carvalho M., Govorkova E., Greim R., Hulsbergen W., Hynds D., Jans E., Koppenburg P., Kostiuk I., Merk M., Mulder M., Pellegrino A., Sanchez Gras C., Tuning N., van Beuzekom M., van Tilburg J., van Veghel M., Vazquez Sierra C., Veronesi M., Vitkovskiy A., Ketel T., Raven G., Syropoulos V., Bhom J., Brodzicka J., Dziurda A., Kucewicz W., Kucharczyk M., Lesiak T., Malecki B., Ossowska A., Pikies M., Witek M., Dendek A., Firlej M., Fiutowski T., Idzik M., Krupa W., Majewski M. 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M., dos Reis A. C., Gomes A., Massafferri A., Molina Rodriguez J., Soares Lavra L., Tourinho Jadallah Aoude R., Amato S., Carvalho Akiba K., Da Cunha Marinho F., De Paula L., Ferreira Rodrigues F., Gandelman M., Hicheur A., Lopes J. H., Nasteva I., Otalora Goicochea J. M., Polycarpo E., Potterat C., Rangel M. S., Silva de Oliveira L., Souza De Paula B., An L., Chen C., Davis A., Gan Y., Gao Y., Gu C., Jiang F., Li T., Liu X., Ren Z., Sun J., Tang Z., Wang M., Xu A., Xu Z., Yang Z., Zhang L., Zhang W. C., Zhu X., Chefdeville M., Decamp D., Ghez P., Marchand J. F., Minard M. -N., Pietrzyk B., Reboud M., T'Jampens S., Tournefier E., Ajaltouni Z., Cogneras E., Deschamps O., Gazzoni G., Hadjivasiliou C., Kozeiha M., Lefevre R., Maratas J., Monteil S., Perret P., Quintana B., Tisserand V., Vernet M., Arnau Romeu J., Aslanides E., Cogan J., Gerstel D., Le Gac R., Leroy O., Mancinelli G., Martin M., Meaux C., Morris A. B., Serrano J., Tayduganov A., Tsaregorodtsev A., Amhis Y., Balagura V., Barsuk S., Bossu F., Chamont D., Coelho J. A. B., Desse F., Fleuret F., Lefrancois J., Lisovskyi V., Machefert F., Marin Benito C., Maurice E., Renaudin V., Robbe P., Schune M. H., Stocchi A., Usachov A., Winn M., Wormser G., Zhang Y., Ben-Haim E., Bertholet E., Billoir P., Charles M., Del Buono L., Dujany G., Gligorov V. V., Mogini A., Polci F., Quagliani R., Reiss F., Robert A., Sepulveda E. S., Tou D. Y., Beranek S., Boubdir M., Escher S., Kirn T., Langenbruch C., Materok M., Nieswand S., Schael S., Smith E., Verlage T. A., Whitehead M., Zhukov V., Albrecht J., Birnkraut A., Demmer M., Eitschberger U., Ekelhof R., Gavardi L., Heinicke K., Heister A., Ibis P., Mackowiak P., Meier F., Modden A., Mombacher T., Muller J., Muller V., Niet R., Reichert S., Schellenberg M., Schmelzer T., Seuthe A., Spaan B., Stevens H., Tekampe T., Wishahi J., Dembinski H. -P., Klimkovich T., Schmelling M., Zavertyaev M., Bachmann S., Berninghoff D., Braun S., Comerma-Montells A., d'Argent P., Dziewiecki M., Gerick D., Grabowski J. P., Han X., Hansmann-Menzemer S., Kecke M., Khanji B., Kolpin M., Kopecna R., Leverington B., Marks J., Mitzel D. S., Neubert S., Neuner M., Piucci A., Skidmore N., Stahl M., Stemmle S., Uwer U., Zhelezov A., McNulty R., Veronika N. V., De Serio M., Fini R. A., Palano A., Pastore A., Simone S., Betti F., Carbone A., Falabella A., Ferrari F., Galli D., Marconi U., O'Hanlon D. P., Patrignani C., Soares M., Vagnoni V., Valenti G., Zucchelli S., Andreotti M., Baldini W., Bozzi C., Calabrese R., Corvo M., Fiorini M., Luppi E., Minzoni L., Pappalardo L. L., Siddi B. G., Tellarini G., Tomassetti L., Vecchi S., Anderlini L., Bizzeti A., Graziani G., Passaleva G., Veltri M., Albicocco P., Bencivenni G., Campana P., Ciambrone P., De Simone P., Di Nezza P., Klaver S., Lanfranchi G., Morello G., Ogilvy S., Palutan M., Poli Lener M., Rotondo M., Santimaria M., Sarti A., Sciascia B., Cardinale R., Cavallero G., Fontanelli F., Petrolini A., Belloli N., Calvi M., Carniti P., Cassina L., Fazzini D., Gotti C., Matteuzzi C., Fu J., Gandini P., Marangotto D., Merli A., Neri N., Petruzzo M., Audurier B., Brundu D., Bursche A., Cadeddu S., Cardini A., Chen S., Contu A., Fontana M., Griffith P., Lai A., Loi A., Manca G., Oldeman R., Saitta B., Amerio S., Bertolin A., Gallorini S., Lucchesi D., Lupato A., Michielin E., Morandin M., Sestini L., Simi G., Bedeschi F., Cenci R., Lusiani A., Morello M. J., Pajero T., Punzi G., Rama M., Stracka S., Tonelli D., Tuci G., Walsh J., Carboni G., Federici L., Santovetti E., Satta A., Bocci V., Martellotti G., Penso G., Pinci D., Santacesaria R., Satriano C., Sciubba A., Aaij R., Ali S., Archilli F., Bel L. J., Benson S., Dall'Occo E., de Vries J. A., Dufour L., Esen S., Feo Pereira Rivello Carvalho M., Govorkova E., Greim R., Hulsbergen W., Hynds D., Jans E., Koppenburg P., Kostiuk I., Merk M., Mulder M., Pellegrino A., Sanchez Gras C., Tuning N., van Beuzekom M., van Tilburg J., van Veghel M., Vazquez Sierra C., Veronesi M., Vitkovskiy A., Ketel T., Raven G., Syropoulos V., Bhom J., Brodzicka J., Dziurda A., Kucewicz W., Kucharczyk M., Lesiak T., Malecki B., Ossowska A., Pikies M., Witek M., Dendek A., Firlej M., Fiutowski T., Idzik M., Krupa W., Majewski M. W., Moron J., Oblakowska-Mucha A., Rachwal B., Swientek K., Szumlak T., Tobin M., Batozskaya V., Klimaszewski K., Krzemien W., Melnychuk D., Ukleja A., Wislicki W., Cojocariu L., Ene A., Giubega L., Grecu A., Maciuc F., Placinta V., Straticiuc M., Alkhazov G., Bondar N., Chubykin A., Dzyuba A., Ivshin K., Kotriakhova S., Maev O., Maisuzenko D., Sagidova N., Shcheglov Y., Stepanova M., Vorobyev A., Belyaev I., Danilina A., Egorychev V., Golubkov D., Kvaratskheliya T., Pereima D., Savrina D., Semennikov A., Berezhnoy A., Gorelov I. V., Leflat A., Nikitin N., Volkov V., Filippov S., Gushchin E., Kravchuk L., Arzymatov K., Baranov A., Borisyak M., Chekalina V., Derkach D., Hushchyn M., Kazeev N., Khairullin E., Ratnikov F., Rogozhnikov A., Ustyuzhanin A., Bondar A., Eidelman S., Krokovny P., Kudryavtsev V., Maltsev T., Shekhtman L., Vorobyev V., Artamonov A., Belous K., Dzhelyadin R., Guz Y., Obraztsov V., Popov A., Poslavskii S., Romanovskiy V., Shapkin M., Stenyakin O., Yushchenko O., Alfonso Albero A., Calvo Gomez M., Camboni A., Coquereau S., Garrido L., Gascon D., Graciani Diaz R., Grauges E., Vilasis-Cardona X., Adeva B., Alves A. A., Boente Garcia O., Borsato M., Chobanova V., Cid Vidal X., Dosil Suarez A., Fernandez Prieto A., Gallas Torreira A., Garcia Plana B., Lucio Martinez M., Martinez Santos D., Plo Casasus M., Prisciandaro J., Ramos Pernas M., Romero Vidal A., Saborido Silva J. J., Sanmartin Sedes B., Santamarina Rios C., Vazquez Regueiro P., Vieites Diaz M., Alessio F., Blago M. P., Brodski M., Buytaert J., Byczynski W., Campora Perez D. H., Cattaneo M., Charpentier P., Chitic S. -G., Chrzaszcz M., Ciezarek G., Clemencic M., Closier J., Coco V., Collins P., Colombo T., Coombs G., Corti G., Couturier B., D'Ambrosio C., De Aguiar Francisco O., De Bruyn K., Di Canto A., Dijkstra H., Dordei F., Dorigo M., Durante P., Farber C., Fernandez Declara P., Ferro-Luzzi M., Forty R., Frank M., Frei C., Funk W., Gaspar C., Granado Cardoso L. A., Gruber L., Gys T., Haen C., Hasse C., Hatch M., Jacobsson R., Johnson D., Joram C., Jost B., Karacson M., Lacarrere D., Lemaitre F., Lindner R., Lupton O., Martinelli M., Matev R., Mathe Z., Muller D., Neufeld N., Nolte N. S., Pearce A., Pepe Altarelli M., Perazzini S., Pinzino J., Pisani F., Ponce S., Ravonel Salzgeber M., Roehrken M., Roiser S., Ruf T., Schindler H., Schmidt B., Schopper A., Schwemmer R., Seyfert P., Stagni F., Stahl S., Teubert F., Thomas E., Tolk S., Valassi A., Valat S., van Herwijnen E., Vazquez Gomez R., Viana Barbosa J. V., Voneki B., Wyllie K., Andreassi G., Battista V., Bay A., Bellee V., Blanc F., De Cian M., Ferreira Lopes L., Fitzpatrick C., Giani S., Girard O. G., Haefeli G., Hopchev P. H., Khurewathanakul C., Kuonen A. K., Macko V., Marinangeli M., Marino P., Maurin B., Nakada T., Nanut T., Nguyen T. D., Nguyen-Mau C., Pais P. R., Pescatore L., Pietrzyk G., Redi F., Rodrigues A. B., Schneider O., Schubiger M., Stefko P., Stramaglia M. E., Tran M. T., Atzeni M., Bernet R., Betancourt C., Bezshyiko I., Buonaura A., Garcia Pardinas J., Graverini E., Lancierini D., Lionetto F., Mauri A., Muller K., Owen P., Puig Navarro A., Serra N., Silva Coutinho R., Steinkamp O., Storaci B., Straumann U., Vollhardt A., Wang Z., Weiden A., Dovbnya A., Kandybei S., Koliiev S., Pugatch V., Bifani S., Calladine R., Chatzikonstantinidis G., Farley N., Ilten P., Lazzeroni C., Mazurov A., Plews J., Popov D., Sergi A., Watson N. K., Williams T., Zarebski K. A., Adinolfi M., Bhasin S., Buchanan E., Chapman M. G., Dalseno J., Harnew S. T., Kariuki J. M., Maddrell-Mander S., Naik P., Petridis K., Pomery G. J., Price E., Prouve C., Rademacker J. H., Richards S., Velthuis J. J., Bettler M. O., Cliff H. V., Delaney B., Garra Tico J., Gibson V., Haines S. C., Jones C. R., Keizer F., Kenzie M., Lovell G. H., Smeaton J. G., Trisovic A., Tully A., Vitti M., Ward D. R., Williams I., Wotton S. A., Back J. J., Blake T., Brossa Gonzalo A., Costa Sobral C. M., Crocombe A., Gershon T., Kreps M., Latham T., Loh D., Mathad A., Millard E., Poluektov A., Wicht J., Easo S., Nandakumar R., Papanestis A., Ricciardi S., Wilson F. F., Carson L., Clarke P. E. L., Cowan G. A., Currie R., Eisenhardt S., Gabriel E., Gambetta S., Gizdov K., Muheim F., Needham M., Pappagallo M., Petrucci S., Playfer S., Smith I. T., Zonneveld J. B., Alexander M., Beddow J., Bobulska D., Dean C. T., Douglas L., Eklund L., Karodia S., Longstaff I., Schiller M., Soler F. J. P., Spradlin P., Traill M., Bowcock T. J. V., Casse G., Dettori F., Dreimanis K., Farry S., Franco Lima V., Harrison T., Hennessy K., Hutchcroft D., Marshall P. J., Mead J. V., Rinnert K., Shears T., Wark H. M., Yeomans L. E., Alvarez Cartelle P., Baker S., Egede U., Golutvin A., Hecker M., Humair T., Kress F., McCann M., Patel M., Smith M., Stefkova S., Tilley M. J., Websdale D., Appleby R. B., Barlow R. J., Barter W., Borghi S., Burr C., Capriotti L., De Capua S., Dutta D., Gersabeck E., Gersabeck M., Grillo L., Hidalgo Charman R., Hilton M., Lafferty G., Maguire K., McNab A., Murray D., Parkes C., Sarpis G., Williams M. R. J., Bjorn M., Gruberg Cazon B. R., Hadavizadeh T., Hancock T. H., Harnew N., Hill D., Jalocha J., John M., Jurik N., Malde S., Murphy C. H., Nandi A., Pili M., Pullen H., Rollings A., Veneziano G., Vesterinen M., Wilkinson G., Boettcher T., Craik D. C., Weisser C., Williams M., Akar S., Evans T., Huard Z. C., Meadows B., Rodrigues E., Schreiner H. F., Sokoloff M. D., Andrews J. E., Hamilton B., Jawahery A., Parker W., Wimberley J., Artuso M., Batsukh B., Beiter A., Blusk S., Ely S., Kelsey M., Kim K. E., Li Z., Liang X., Mountain R., Polyakov I., Rudolph M. S., Skwarnicki T., Stone S., Venkateswaran A., Wang J., Wilkinson M., Yao Y., Yuan X., Gobel C., Salustino Guimaraes V., Beliy N., He J., Huang W., Li P. -R., Lyu X., Qian W., Qin J., Saur M., Szymanski M., Vieira D., Xu Q., Zheng Y., Cai H., Sun L., Dey B., Hu W., Wang Y., Xiao D., Xie Y., Xu M., Yin H., Yu J., Zhang D., Milanes D. A., Monroy I. A., Rodriguez Lopez J. A., Grunberg O., Hess M., Meinert N., Viemann H., Waldi R., Onderwater C. J. G., Likhomanenko T., Malinin A., Morgunova O., Nogay A., Petrov A., Shevchenko V., Baryshnikov F., Didenko S., Polukhina N., Shmanin E., Panshin G., Strokov S., Vagner A., Garcia Martin L. M., Henry L., Martinez Vidal F., Oyanguren A., Remon Alepuz C., Ruiz Vidal J., Sanchez Mayordomo C., Aidala C. A., Da Silva C. L., and Durham J. M.
Published: 2019

50. Measurement of CP observables in the process B0 → DK *0 with two- and four-body D decays

Author: Aaij, R, Abellan Beteta, C, Adeva, B, Adinolfi, M, Aidala, C, Ajaltouni, Z, Akar, S, Albicocco, P, Albrecht, J, Alessio, F, Alexander, M, Alfonso Albero, A, Alkhazov, G, Alvarez Cartelle, P, Alves, A, Amato, S, Amhis, Y, An, L, Anderlini, L, Andreassi, G, Andreotti, M, Andrews, J, Archilli, F, Arnau Romeu, J, Artamonov, A, Artuso, M, Arzymatov, K, Aslanides, E, Atzeni, M, Audurier, B, Bachmann, S, Back, J, Baker, S, Balagura, V, Baldini, W, Baranov, A, Barlow, R, Barsuk, S, Barter, W, Bartolini, M, Baryshnikov, F, Batozskaya, V, Batsukh, B, Battig, A, Battista, V, Bay, A, Bedeschi, F, Bediaga, I, Beiter, A, Bel, L, Belavin, V, Belin, S, Beliy, N, Bellee, V, Belous, K, Belyaev, I, Bencivenni, G, Ben-Haim, E, Benson, S, Beranek, S, Berezhnoy, A, Bernet, R, Berninghoff, D, Bertholet, E, Bertolin, A, Betancourt, C, Betti, F, Bettler, M, Bezshyiko, I, Bhasin, S, Bhom, J, Bieker, M, Bifani, S, Billoir, P, Birnkraut, A, Bizzeti, A, Bjorn, M, Blago, M, Blake, T, Blanc, F, Blusk, S, Bobulska, D, Bocci, V, Boentegarcia, O, Boettcher, T, Boldyrev, A, Bondar, A, Bondar, N, Borghi, S, Borisyak, M, Borsato, M, Boubdir, M, Bowcock, T, Bozzi, C, Braun, S, Brearodriguez, A, Brodski, M, Brodzicka, J, Brossagonzalo, A, Brundu, D, Buchanan, E, Buonaura, A, Burr, C, Bursche, A, Butter, J, Buytaert, J, Byczynski, W, Cadeddu, S, Cai, H, Calabrese, R, Cali, S, Calladine, R, Calvi, M, Calvo Gomez, M, Camboni, A, Campana, P, Camporaperez, D, Capriotti, L, Carbone, A, Carboni, G, Cardinale, R, Cardini, A, Carniti, P, Carvalho Akiba, K, Casais Vidal, A, Casse, G, Cattaneo, M, Cavallero, G, Cenci, R, Chapman, M, Charles, M, Charpentier, P, Chatzikonstantinidis, G, Chefdeville, M, Chekalina, V, Chen, C, Chen, S, Chitic, S, Chobanova, V, Chrzaszcz, M, Chubykin, A, Ciambrone, P, Cid Vidal, X, Ciezarek, G, Cindolo, F, Clarke, P, Clemencic, M, Cliff, H, Closier, J, Cobbledick, J, Coco, V, Coelho, J, Cogan, J, Cogneras, E, Cojocariu, L, Collins, P, Colombo, T, Comerma-Montells, A, Contu, A, Cooke, N, Coombs, G, Coquereau, S, Corti, G, Costasobral, C, Couturier, B, Cowan, G, Craik, D, Crocombe, A, Torres, M, Currie, R, Da Silva, C, Dall'Occo, E, Dalseno, J, D'Ambrosio, C, Danilina, A, D'Argent, P, Davis, A, De Aguiar Francisco, O, De Bruyn, K, De Capua, S, De Cian, M, De Miranda, J, De Paula, L, De Serio, M, De Simone, P, de Vries, J, Dean, C, Dean, W, Decamp, D, Del Buono, L, Delaney, B, Dembinski, H, Demmer, M, Dendek, A, Denysenko, V, Derkach, D, Deschamps, O, Desse, F, Dettori, F, Dey, B, Di Canto, A, Di Nezza, P, Didenko, S, Dijkstra, H, Dordei, F, Dorigo, M, dos Reis, A, Dosil Suarez, A, Douglas, L, Dovbnya, A, Dreimanis, K, Dufour, L, Dujany, G, Durante, P, Durham, J, Dutta, D, Dzhelyadin, R, Dziewiecki, M, Dziurda, A, Dzyuba, A, Easo, S, Egede, U, Egorychev, V, Eidelman, S, Eisenhardt, S, Eitschberger, U, Ekelhof, R, Ek-In, S, Eklund, L, Ely, S, Ene, A, Escher, S, Esen, S, Evans, T, Falabella, A, Farber, C, Farley, N, Farry, S, Fazzini, D, Feo, M, Fernandez Declara, P, Fernandez Prieto, A, Ferrari, F, Ferreira Lopes, L, Ferreira Rodrigues, F, Ferreres Sole, S, Ferro-Luzzi, M, Filippov, S, Fini, R, Fiorini, M, Firlej, M, Fitzpatrick, C, Fiutowski, T, Fleuret, F, Fontana, M, Fontanelli, F, Forty, R, Franco Lima, V, Franco Sevilla, M, Frank, M, Frei, C, Fu, J, Funk, W, Gabriel, E, Gallas Torreira, A, Galli, D, Gallorini, S, Gambetta, S, Gan, Y, Gandelman, M, Gandini, P, Gao, Y, Garcia Martin, L, Garcia Pardinas, J, Garcia Plana, B, Garra Tico, J, Garrido, L, Gascon, D, Gaspar, C, Gazzoni, G, Gerick, D, Gersabeck, E, Gersabeck, M, Gershon, T, Gerstel, D, Ghez, P, Gibson, V, Gioventu, A, Girard, O, Gironella Gironell, P, Giubega, L, Gizdov, K, Gligorov, V, Gobel, C, Golubkov, D, Golutvin, A, Gomes, A, Gorelov, I, Gotti, C, Govorkova, E, Grabowski, J, Graciani Diaz, R, Granado Cardoso, L, Grauges, E, Graverini, E, Graziani, G, Grecu, A, Greim, R, Griffith, P, Grillo, L, Gruber, L, Gruberg Cazon, B, Gu, C, Gushchin, E, Guth, A, Guz, Y, Gys, T, Hadavizadeh, T, Hadjivasiliou, C, Haefeli, G, Haen, C, Haines, S, Hamilton, P, Han, Q, Han, X, Hancock, T, Hansmann-Menzemer, S, Harnew, N, Harrison, T, Hasse, C, Hatch, M, He, J, Hecker, M, Heijhoff, K, Heinicke, K, Heister, A, Hennessy, K, Henry, L, Hess, M, Heuel, J, Hicheur, A, Hidalgo Charman, R, Hill, D, Hilton, M, Hopchev, P, Hu, J, Hu, W, Huang, W, Huard, Z, Hulsbergen, W, Humair, T, Hushchyn, M, Hutchcroft, D, Hynds, D, Ibis, P, Idzik, M, Ilten, P, Inglessi, A, Inyakin, A, Ivshin, K, Jacobsson, R, Jakobsen, S, Jalocha, J, Jans, E, Jashal, B, Jawahery, A, Jiang, F, John, M, Johnson, D, Jones, C, Joram, C, Jost, B, Jurik, N, Kandybei, S, Karacson, M, Kariuki, J, Karodia, S, Kazeev, N, Kecke, M, Keizer, F, Kelsey, M, Kenzie, M, Ketel, T, Khanji, B, Kharisova, A, Khurewathanakul, C, Kim, K, Kirn, T, Kirsebom, V, Klaver, S, Klimaszewski, K, Kodassery Padmalayammadam, P, Koliiev, S, Kolpin, M, Kondybayeva, A, Konoplyannikov, A, Kopciewicz, P, Kopecna, R, Koppenburg, P, Kostiuk, I, 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Abstract: Measurements of CP observables in B-0 -> DK0 decays are presented, where D represents a superposition of D-0 and D0 states. The D meson is reconstructed in the two-body final states K+pi(-), pi K-+(-), K+K- and pi(+)pi(-), and, for the first time, in the fourbody final states K+pi(-)pi(+)pi(-), pi K-+(-)pi(+)pi(-) and pi(+)pi(-)pi(+)pi(-). The analysis uses a sample of neutral B mesons produced in proton-proton collisions, corresponding to an integrated luminosity of 1.0, 2.0 and 1.8 fb(-1) collected with the LHCb detector at centre-of-mass energies of ,8 and 13 TeV, respectively. First observations of the decays B-0 -> D(pi K-+(-))K-0 and B-0 -> D(pi(+)pi(-)pi(+)pi(-))K-0 are obtained. The measured observables are interpreted in terms of the CP -violating weak phase gamma.
Published: 2019

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