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In this short review definition, mechanism, and recent developments of the Stetter reaction, in the period last ten years from 2011 to 2021 are presented. This reaction comprises N-heterocyclic carbene (NHC)-catalyzed umpolung of aldehydes followed by their capturing with activated carbon-carbon double bonds (Michael acceptors). This work includes also progresses in the inter-molecular and intra-molecular versions and enantioselective transformations. Underscoring the recent advances in the applications of Stetter reaction in the synthesis of various heterocyclic systems and total synthesis of natural products have been also introduced.

In this short review definition, mechanism, and recent developments of the Stetter reaction, in the period last ten years from 2011 to 2021 are presented. This reaction comprises N-heterocyclic carbene (NHC)-catalyzed umpolung of aldehydes followed by their capturing with activated carbon-carbon double bonds (Michael acceptors). This work includes also progresses in the inter-molecular and intra-molecular versions and enantioselective transformations. Underscoring the recent advances in the applications of Stetter reaction in the synthesis of various heterocyclic systems and total synthesis of natural products have been also introduced.

In this short review definition, mechanism, and recent developments of the Stetter reaction, in the period last ten years from 2011 to 2021 are presented. This reaction comprises N-heterocyclic carbene (NHC)-catalyzed umpolung of aldehydes followed by their capturing with activated carbon-carbon double bonds (Michael acceptors). This work includes also progresses in the inter-molecular and intra-molecular versions and enantioselective transformations. Underscoring the recent advances in the applications of Stetter reaction in the synthesis of various heterocyclic systems and total synthesis of natural products have been also introduced.

Thiazolium carbene-catalyzed reactions of 1,2-diketones and 1,2,3-triketones with enones and ynones have been investigated. The diketones gave α,β-double acylation products via unique Breslow intermediates isolable as acid salts, whereas the triketones formed stable adducts with the NHC instead of the coupling products.

De nombreux produits naturels renferment dans leurs structures une ou plusieurs sous-unités bicycliques. Parmi celles-ci, les hydrindanes et les décalines occupent une position privilégiée. Afin d'accéder à ces composés, deux approches originales ont été développées. Elles se basent sur un couplage de Morita-Baylis-Hillman, suivi d'une cyclisation réductrice ou d'une réaction de Stetter intramoléculaire. Outre la synthèse rapide et efficace d'hydrindanones et de décalones substituées, ces séquences réactionnelles ont permis la création d'une large variété d'ènediones bicycliques. L'intérêt de ces méthodologies a pu être illustré lors de la synthèse d'une phytotoxine, l'acide coronafacique., A large variety of natural products contain, embedded in their architectural framework, one or more bicyclic subunits. Among them, hydrindanes and decalins occupy a cardinal position. As novel approaches towards these substructures, we have developed original sequences based upon two key steps: a Morita-Baylis-Hillman condensation, followed by a reductive cyclisation or an intramolecular Stetter reaction. Having delineated suitable conditions, a rapid and connective synthesis of substituted hydrindanones and decalones can thus be accomplished. The strength of our methodologies was also exemplified by the formation of various bicyclic enediones and their application in the synthesis of coronafacic acid, a phytotoxin., (CHIM 3)--UCL, 2006