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Specimens of Bactrocera carambolae Drew & Hancock, 1994 (Diptera: Tephritidae) were obtained from fruits of Averrhoa bilimbi L., Averrhoa carambola L. (Oxalidaceae), Malpighia emarginata DC. (Malpighiaceae), and Psidium guajava L. (Myrtaceae), from a survey carried out in Lethem, Republic of Guyana. This is the first record of B. carambolae in A. bilimbi, M. emarginata and P. guajava in the country.

Objectives: Antinuclear antibodies (ANA) are important for the diagnosis of various autoimmune diseases. ANA are usually detected by indirect immunofluorescence assay (IFA) using HEp-2 cells (HEp-2 IFA). There are many variables influencing HEp-2 IFA results, such as subjective visual reading, serum screening dilution, substrate manufacturing, microscope components and conjugate. Newer developments on ANA testing that offer novel features adopted by some clinical laboratories include automated computer-assisted diagnosis (CAD) systems and solid phase assays (SPA). Methods: A group of experts reviewed current literature and established recommendations on methodological aspects of ANA testing. This process was supported by a two round Delphi exercise. International expert groups that participated in this initiative included (i) the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Working Group “Autoimmunity Testing”; (ii) the European Autoimmune Standardization Initiative (EASI); and (iii) the International Consensus on ANA Patterns (ICAP). Results: In total, 35 recommendations/statements related to (i) ANA testing and reporting by HEp-2 IFA; (ii) HEp-2 IFA methodological aspects including substrate/conjugate selection and the application of CAD systems; (iii) quality assurance; (iv) HEp-2 IFA validation/verification approaches and (v) SPA were formulated. Globally, 95% of all submitted scores in the final Delphi round were above 6 (moderately agree, agree or strongly agree) and 85% above 7 (agree and strongly agree), indicating strong international support for the proposed recommendations. Conclusions: These recommendations are an important step to achieve high quality ANA testing.

Funding Agencies|Structured Program of Ramp;Damp;I INNOVMAR-Innovation and Sustainability in the Management and Exploitation of Marine Resources [NORTE-01-0145-FEDER-000035]; Northern Regional Operational Program (NORTE2020) through the European RegionalDevelopment Fund (ERDF); NORTE 2020 [PTDC/MED-QUI/30944/2017 -NORTE-01-0145-FEDER-030944]; Portugal 2020; European Union through the ERDF; Foundation for Science and Technology

Objectives: Antinuclear antibodies (ANA) are important for the diagnosis of various autoimmune diseases. ANA are usually detected by indirect immunofluorescence assay (IFA) using HEp-2 cells (HEp-2 IFA). There are many variables influencing HEp-2 IFA results, such as subjective visual reading, serum screening dilution, substrate manufacturing, microscope components and conjugate. Newer developments on ANA testing that offer novel features adopted by some clinical laboratories include automated computer-assisted diagnosis (CAD) systems and solid phase assays (SPA). Methods: A group of experts reviewed current literature and established recommendations on methodological aspects of ANA testing. This process was supported by a two round Delphi exercise. International expert groups that participated in this initiative included (i) the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Working Group “Autoimmunity Testing”; (ii) the European Autoimmune Standardization Initiative (EASI); and (iii) the International Consensus on ANA Patterns (ICAP). Results: In total, 35 recommendations/statements related to (i) ANA testing and reporting by HEp-2 IFA; (ii) HEp-2 IFA methodological aspects including substrate/conjugate selection and the application of CAD systems; (iii) quality assurance; (iv) HEp-2 IFA validation/verification approaches and (v) SPA were formulated. Globally, 95% of all submitted scores in the final Delphi round were above 6 (moderately agree, agree or strongly agree) and 85% above 7 (agree and strongly agree), indicating strong international support for the proposed recommendations. Conclusions: These recommendations are an important step to achieve high quality ANA testing.

Funding Agencies|Structured Program of Ramp;Damp;I INNOVMAR-Innovation and Sustainability in the Management and Exploitation of Marine Resources [NORTE-01-0145-FEDER-000035]; Northern Regional Operational Program (NORTE2020) through the European RegionalDevelopment Fund (ERDF); NORTE 2020 [PTDC/MED-QUI/30944/2017 -NORTE-01-0145-FEDER-030944]; Portugal 2020; European Union through the ERDF; Foundation for Science and Technology

Objectives: Antinuclear antibodies (ANA) are important for the diagnosis of various autoimmune diseases. ANA are usually detected by indirect immunofluorescence assay (IFA) using HEp-2 cells (HEp-2 IFA). There are many variables influencing HEp-2 IFA results, such as subjective visual reading, serum screening dilution, substrate manufacturing, microscope components and conjugate. Newer developments on ANA testing that offer novel features adopted by some clinical laboratories include automated computer-assisted diagnosis (CAD) systems and solid phase assays (SPA). Methods: A group of experts reviewed current literature and established recommendations on methodological aspects of ANA testing. This process was supported by a two round Delphi exercise. International expert groups that participated in this initiative included (i) the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Working Group “Autoimmunity Testing”; (ii) the European Autoimmune Standardization Initiative (EASI); and (iii) the International Consensus on ANA Patterns (ICAP). Results: In total, 35 recommendations/statements related to (i) ANA testing and reporting by HEp-2 IFA; (ii) HEp-2 IFA methodological aspects including substrate/conjugate selection and the application of CAD systems; (iii) quality assurance; (iv) HEp-2 IFA validation/verification approaches and (v) SPA were formulated. Globally, 95% of all submitted scores in the final Delphi round were above 6 (moderately agree, agree or strongly agree) and 85% above 7 (agree and strongly agree), indicating strong international support for the proposed recommendations. Conclusions: These recommendations are an important step to achieve high quality ANA testing.

This article discusses the results of a post-doctoral research that conducted an in-depth theoretical exploration on the concept of shared supervised practice and mobilized this study for the initial and continuing education of mathematics teachers. These results stem from the possibilities and challenges that emerged during four internship disciplines of the Mathematics degree course, in the remote context. Thus, theoretical reflections on literary works that dialogue with the theme are presented. Then, we contextualize these four disciplines, taught remotely in the second half of 2020, at the Federal University of São Carlos (UFSCar), São Carlos (SP) campus. Qualitative in nature, the research uses data obtained from theoretical tasks performed by the undergraduates and from class recordings, which took place via Google Meet. During the pandemic, the mobilizations that took place in the initial and continuing education of mathematics teachers were: theoretical, through studies about concepts that support shared supervised practice and through the interlocution with critical mathematics education, which are manifested in the professor’s practice by intentionality in organizing teaching; and methodological, through the pedagogical proposals planned to be offered remotely, mobilizing undergraduates and basic education teachers to debate among themselves and to examine literature that would allow them to create tasks that would overcome the logic of the exercise paradigm., O objetivo deste artigo é discutir os resultados de uma pesquisa de pós-doutoramento, que teve como propósito realizar um aprofundamento teórico acerca do conceito de estágio compartilhado e mobilizar esse estudo para a formação inicial e continuada de professores de matemática. Esses resultados estão relacionados, particularmente, às possibilidades e aos desafios que se manifestaram durante o desenvolvimento de quatro disciplinas de estágio do curso de licenciatura de matemática, no contexto remoto. Para tanto, trazem-se reflexões teóricas sobre obras literárias que dialogam com a temática do artigo. Em seguida, é feita uma contextualização acerca dessas quatro disciplinas, ministradas remotamente no segundo semestre de 2020, na Universidade Federal de São Carlos (UFSCar), campus de São Carlos (SP). A metodologia de pesquisa é qualitativa, e os dados são provenientes de tarefas teóricas realizadas pelos licenciandos e de gravações das aulas, que ocorreram via Google Meet. Observa-se que as mobilizações que ocorreram na formação inicial e continuada de professores de matemática, nesse cenário, foram: teóricas, por meio dos estudos realizados sobre conceitos que estão na base do estágio compartilhado e por meio da interlocução feita com a educação matemática crítica, que se manifestam na prática das formadoras por meio da intencionalidade na organização do ensino; e metodológicas, por meio das propostas pedagógicas que tiveram que ser planejadas para serem ofertadas remotamente, mobilizando licenciandos e professores da educação básica a debaterem entre si e a estudarem obras literárias que lhes permitissem criar tarefas que buscassem superar a lógica do paradigma do exercício.

Funding Agencies|Structured Program of Ramp;Damp;I INNOVMAR-Innovation and Sustainability in the Management and Exploitation of Marine Resources [NORTE-01-0145-FEDER-000035]; Northern Regional Operational Program (NORTE2020) through the European RegionalDevelopment Fund (ERDF); NORTE 2020 [PTDC/MED-QUI/30944/2017 -NORTE-01-0145-FEDER-030944]; Portugal 2020; European Union through the ERDF; Foundation for Science and Technology

Water scarcity and security drive attention to water reuse in policy and business. However, water reuse may generate new water loops and challenge water governance with new and different types of water, risks, involved actors, and responsibilities. These challenges demand robust institutional arrangements related to water governance. This article assesses the institutional arrangements associated with four case studies in Spain, Italy, Croatia, and Israel. The findings reveal that the more diverse the water uses and users, the more challenges and risks, particularly those associated with institutional arrangements such as quality standards, sanctions, and conflict prevention, are likely to emerge. The weaknesses of governance models and regulations to deal with changes, uncertainties, and public resistance call for special attention to the design of the institutional arrangements before the adoption. Independent of the type of technology adopted, governance may be improved by ensuring internal and external water monitoring; integrating water management with spatial concerns; improving training, expert engagement, and civil society awareness; and reducing water reuse costs. In addition, alternative models that guarantee the efficiency of governance in attaining objectives and assuring the participation of new water users in the management of water reuse loops may also improve governance.

Apresentação do Dossiê Temático, Apresentation

O artigo apresenta algumas reflexões sobre o Centenário (1922) e o Bicentenário da Independência do Brasil (2022), com destaque para os respectivos contextos históricos e os desafios postos para a nação brasileira nas distintas temporalidades. Propõe, ainda, pensar como a complexidade do processo de formação do país independente expôs profundos problemas, conflitos e contradições que muito dizem sobre os tempos atuais., The article point some reflections on the celebrations of the centenary (1922) and the bicentennial of the Independence of Brazil (2022) and inquires about the similarities and differences in both contexts in which the discussion about the Brazilian nation was in evidence. It also problematizes the challenges for the construction of the Nation in the 19th century in the midst of social tensions and the insertion of popular segments.

Apresentação do Dossiê Temático, Apresentation

This paper presents the first publicly available version of the Carolina Corpus and discusses its future directions. Carolina is a large open corpus of Brazilian Portuguese texts under construction using web-as-corpus methodology enhanced with provenance, typology, versioning, and text integrality. The corpus aims at being used both as a reliable source for research in Linguistics and as an important resource for Computer Science research on language models, contributing towards removing Portuguese from the set of low-resource languages. Here we present the construction of the corpus methodology, comparing it with other existing methodologies, as well as the corpus current state: Carolina's first public version has $653,322,577$ tokens, distributed over $7$ broad types. Each text is annotated with several different metadata categories in its header, which we developed using TEI annotation standards. We also present ongoing derivative works and invite NLP researchers to contribute with their own., Comment: 14 pages, 3 figures, 1 appendix

Funding Agencies|Structured Program of Ramp;Damp;I INNOVMAR-Innovation and Sustainability in the Management and Exploitation of Marine Resources [NORTE-01-0145-FEDER-000035]; Northern Regional Operational Program (NORTE2020) through the European RegionalDevelopment Fund (ERDF); NORTE 2020 [PTDC/MED-QUI/30944/2017 -NORTE-01-0145-FEDER-030944]; Portugal 2020; European Union through the ERDF; Foundation for Science and Technology

Objectives: Antinuclear antibodies (ANA) are important for the diagnosis of various autoimmune diseases. ANA are usually detected by indirect immunofluorescence assay (IFA) using HEp-2 cells (HEp-2 IFA). There are many variables influencing HEp-2 IFA results, such as subjective visual reading, serum screening dilution, substrate manufacturing, microscope components and conjugate. Newer developments on ANA testing that offer novel features adopted by some clinical laboratories include automated computer-assisted diagnosis (CAD) systems and solid phase assays (SPA). Methods: A group of experts reviewed current literature and established recommendations on methodological aspects of ANA testing. This process was supported by a two round Delphi exercise. International expert groups that participated in this initiative included (i) the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Working Group “Autoimmunity Testing”; (ii) the European Autoimmune Standardization Initiative (EASI); and (iii) the International Consensus on ANA Patterns (ICAP). Results: In total, 35 recommendations/statements related to (i) ANA testing and reporting by HEp-2 IFA; (ii) HEp-2 IFA methodological aspects including substrate/conjugate selection and the application of CAD systems; (iii) quality assurance; (iv) HEp-2 IFA validation/verification approaches and (v) SPA were formulated. Globally, 95% of all submitted scores in the final Delphi round were above 6 (moderately agree, agree or strongly agree) and 85% above 7 (agree and strongly agree), indicating strong international support for the proposed recommendations. Conclusions: These recommendations are an important step to achieve high quality ANA testing.

Objectives: Antinuclear antibodies (ANA) are important for the diagnosis of various autoimmune diseases. ANA are usually detected by indirect immunofluorescence assay (IFA) using HEp-2 cells (HEp-2 IFA). There are many variables influencing HEp-2 IFA results, such as subjective visual reading, serum screening dilution, substrate manufacturing, microscope components and conjugate. Newer developments on ANA testing that offer novel features adopted by some clinical laboratories include automated computer-assisted diagnosis (CAD) systems and solid phase assays (SPA).Methods: A group of experts reviewed current literature and established recommendations on methodological aspects of ANA testing. This process was supported by a two round Delphi exercise. International expert groups that participated in this initiative included (i) the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Working Group "Autoimmunity Testing"; (ii) the European Autoimmune Standardization Initiative (EASI); and (iii) the International Consensus on ANA Patterns (ICAP).Results: In total, 35 recommendations/statements related to (i) ANA testing and reporting by HEp-2 IFA; (ii) HEp-2 IFA methodological aspects including substrate/conjugate selection and the application of CAD systems; (iii) quality assurance; (iv) HEp-2 IFA validation/verification approaches and (v) SPA were formulated. Globally, 95% of all submitted scores in the final Delphi round were above 6 (moderately agree, agree or strongly agree) and 85% above 7 (agree and strongly agree), indicating strong international support for the proposed recommendations.Conclusions: These recommendations are an important step to achieve high quality ANA testing.

Objectives: Antinuclear antibodies (ANA) are important for the diagnosis of various autoimmune diseases. ANA are usually detected by indirect immunofluorescence assay (IFA) using HEp-2 cells (HEp-2 IFA). There are many variables influencing HEp-2 IFA results, such as subjective visual reading, serum screening dilution, substrate manufacturing, microscope components and conjugate. Newer developments on ANA testing that offer novel features adopted by some clinical laboratories include automated computer-assisted diagnosis (CAD) systems and solid phase assays (SPA). Methods: A group of experts reviewed current literature and established recommendations on methodological aspects of ANA testing. This process was supported by a two round Delphi exercise. International expert groups that participated in this initiative included (i) the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Working Group “Autoimmunity Testing”; (ii) the European Autoimmune Standardization Initiative (EASI); and (iii) the International Consensus on ANA Patterns (ICAP). Results: In total, 35 recommendations/statements related to (i) ANA testing and reporting by HEp-2 IFA; (ii) HEp-2 IFA methodological aspects including substrate/conjugate selection and the application of CAD systems; (iii) quality assurance; (iv) HEp-2 IFA validation/verification approaches and (v) SPA were formulated. Globally, 95% of all submitted scores in the final Delphi round were above 6 (moderately agree, agree or strongly agree) and 85% above 7 (agree and strongly agree), indicating strong international support for the proposed recommendations. Conclusions: These recommendations are an important step to achieve high quality ANA testing.

Liquid crystal polymer (LCP) has gained wide interest in the electronics industry largely due to its flexibility, stable insulation and dielectric properties and chip integration capabilities. Recently, LCP has also been investigated as a biocompatible substrate for the fabrication of multielectrode arrays. Realizing a fully implantable LCP-based bioelectronic device, however, still necessitates a low form factor packaging solution to protect the electronics in the body. In this work, we investigate two promising encapsulation coatings based on thin-film technology as the main packaging for LCP-based electronics. Specifically, a HfO2–based nanolaminate ceramic (TFE1) deposited via atomic layer deposition (ALD), and a hybrid Parylene C-ALD multilayer stack (TFE2), both with a silicone finish, were investigated and compared to a reference LCP coating. T-peel, water-vapour transmission rate (WVTR) and long-term electrochemical impedance spectrometry (EIS) tests were performed to evaluate adhesion, barrier properties and overall encapsulation performance of the coatings. Both TFE materials showed stable impedance characteristics while submerged in 60 °C saline, with TFE1-silicone lasting more than 16 months under a continuous 14V DC bias (experiment is ongoing). The results presented in this work show that WVTR is not the main factor in determining lifetime, but the adhesion of the coating to the substrate materials plays a key role in maintaining a stable interface and thus longer lifetimes., Bio-Electronics

The Pampulha Modern Ensemble is an urban complex located in Belo Horizonte, Brazil, whose metropolitan context is highly problematic due to the pressures of urban dynamics, impacts from urban development and the need to manage changes and preserve architectural and landscape attributes that have led to its recognition as World Heritage. This article is part of a larger study that investigates the community's recognition of the values ​​conferred by experts on that complex’s cultural landscape as a world heritage site. Due to the restrictive conditions imposed by the COVID 19 pandemic, an online questionnaire with open access to the general public was used as an instrument for the field research to collect primary data from the community. The analysis of the answers obtained from the questionnaire pre-test, object of this article, demonstrates the recognition of landscape elements and of the Pampulha Modern Ensemble that contribute to its fruition and that characterize it as a differentiated landscape in the context of the city., O Conjunto Moderno da Pampulha é um complexo urbano situado em Belo Horizonte, Brasil, cujo contexto metropolitano apresenta grande complexidade em função de pressões da dinâmica urbana, de impactos ambientais da urbanização e da necessidade de gerir mudanças, preservando os atributos da arquitetura e da paisagem que propiciaram o seu reconhecimento como Patrimônio Mundial. Este artigo é parte de um estudo maior que investiga o reconhecimento pela comunidade dos valores conferidos pelos especialistas à paisagem cultural do Conjunto como patrimônio mundial. Devido às condições restritivas impostas pela pandemia da COVID 19, utilizou-se como instrumento para a pesquisa de campo um questionário online de acesso franqueado ao público em geral para a coleta de dados primários junto à comunidade. A análise das respostas obtidas no pré-teste do questionário, objeto deste artigo, demonstram o reconhecimento de elementos da paisagem e do Conjunto Moderno da Pampulha que contribuem para sua fruição e que o caracteriza como paisagem diferenciada no contexto da cidade., El Conjunto Moderno da Pampulha es un complejo urbano ubicado en Belo Horizonte, Brasil, cuyo contexto metropolitano es altamente problemático debido a las presiones de la dinámica urbana, los impactos ambientales de la urbanización y la necesidad de gestionar los cambios y preservar los atributos de la arquitectura y el paisaje que brindaron su reconocimiento como Patrimonio de la humanidad. Este artículo es parte de un estudio más amplio que investiga el reconocimiento de la comunidad de los valores conferidos por los especialistas al paisaje cultural del Conjunto como Patrimonio de la humanidad. Debido a las condiciones restrictivas impuestas por la pandemia de COVID 19, se utilizó un cuestionario en línea con acceso abierto al público en general, como instrumento para la investigación de campo para recopilar datos primarios de la comunidad. El análisis de las respuestas obtenidas en el pre-test del cuestionario, objeto de este artículo, demuestra el reconocimiento de elementos del paisaje y del Conjunto Moderno da Pampulha que contribuyen a su fructificación y que lo caracterizan como un paisaje diferenciado en el contexto de la ciudad.

Introdução: Fototerapia é a utilização da luz com finalidade terapêutica. Entre os recursos fototerapêuticos destaca-se o LED terapêutico utilizado na prática clínica fisioterapêutica, apresentando potencial efeito sobre o tratamento de afecções diversas. Estudos mostram que a terapia com LED é capaz de produzir efeitos anti-inflamatório, analgésico, estimulador e regenerador celular. No entanto são encontradas poucas evidências sobre os efeitos hipoalgésicos locais e a temperatura cutânea imediatamente após a aplicação do LED. Objetivo: Verificar os efeitos do LED terapêutico sobre a temperatura e o limiar de tolerância de dor à pressão (LTDP) em indivíduos saudáveis mediante termografia e algometria. Métodos: Trata-se de um ensaio clínico randomizado, aprovado pelo comitê de ética em pesquisa. Foram recrutadas 54 mulheres de 18 a 25 anos, randomizadas em três grupos: 1) Controle; 2) LED infravermelho 850nm e 3) LED vermelho 630nm. Os LEDs foram aplicados com fluência de 10J/cm2 durante 3 minutos no ventre do grupo muscular quadríceps direito. Para análise da temperatura cutânea, foi utilizada uma câmera de termografia, e o LTDP foi avaliado pelo algômetro. As avaliações ocorreram antes, imediatamente após e 5 minutos após à intervenção com o LED. Resultados: Os valores obtidos na termografia e algometria não evidenciaram alterações estatisticamente significativas sobre a temperatura e o LTDP, respectivamente, em nenhum dos três momentos avaliados. Conclusão: Os resultados sugerem que o LEDs vermelho e infravermelho, aplicados com fluência de 10J/cm2 durante 3 minutos, não alteram a temperatura e o LTDP em indivíduos saudáveis.

The Pampulha Modern Ensemble is an urban complex located in Belo Horizonte, Brazil, whose metropolitan context is highly problematic due to the pressures of urban dynamics, impacts from urban development and the need to manage changes and preserve architectural and landscape attributes that have led to its recognition as World Heritage. This article is part of a larger study that investigates the community's recognition of the values ​​conferred by experts on that complex’s cultural landscape as a world heritage site. Due to the restrictive conditions imposed by the COVID 19 pandemic, an online questionnaire with open access to the general public was used as an instrument for the field research to collect primary data from the community. The analysis of the answers obtained from the questionnaire pre-test, object of this article, demonstrates the recognition of landscape elements and of the Pampulha Modern Ensemble that contribute to its fruition and that characterize it as a differentiated landscape in the context of the city., O Conjunto Moderno da Pampulha é um complexo urbano situado em Belo Horizonte, Brasil, cujo contexto metropolitano apresenta grande complexidade em função de pressões da dinâmica urbana, de impactos ambientais da urbanização e da necessidade de gerir mudanças, preservando os atributos da arquitetura e da paisagem que propiciaram o seu reconhecimento como Patrimônio Mundial. Este artigo é parte de um estudo maior que investiga o reconhecimento pela comunidade dos valores conferidos pelos especialistas à paisagem cultural do Conjunto como patrimônio mundial. Devido às condições restritivas impostas pela pandemia da COVID 19, utilizou-se como instrumento para a pesquisa de campo um questionário online de acesso franqueado ao público em geral para a coleta de dados primários junto à comunidade. A análise das respostas obtidas no pré-teste do questionário, objeto deste artigo, demonstram o reconhecimento de elementos da paisagem e do Conjunto Moderno da Pampulha que contribuem para sua fruição e que o caracteriza como paisagem diferenciada no contexto da cidade., El Conjunto Moderno da Pampulha es un complejo urbano ubicado en Belo Horizonte, Brasil, cuyo contexto metropolitano es altamente problemático debido a las presiones de la dinámica urbana, los impactos ambientales de la urbanización y la necesidad de gestionar los cambios y preservar los atributos de la arquitectura y el paisaje que brindaron su reconocimiento como Patrimonio de la humanidad. Este artículo es parte de un estudio más amplio que investiga el reconocimiento de la comunidad de los valores conferidos por los especialistas al paisaje cultural del Conjunto como Patrimonio de la humanidad. Debido a las condiciones restrictivas impuestas por la pandemia de COVID 19, se utilizó un cuestionario en línea con acceso abierto al público en general, como instrumento para la investigación de campo para recopilar datos primarios de la comunidad. El análisis de las respuestas obtenidas en el pre-test del cuestionario, objeto de este artículo, demuestra el reconocimiento de elementos del paisaje y del Conjunto Moderno da Pampulha que contribuyen a su fructificación y que lo caracterizan como un paisaje diferenciado en el contexto de la ciudad.

Titanium dioxide (TiO2) and silver (Ag) NPs are among the most used engineered inorganic nanoparticles (NPs); however, their potential effects to marine demersal fish species, are not fully understood. Therefore, this study aimed to assess the proteomic alterations induced by sub-lethal concentrations citrate-coated 25 nm ("P25") TiO2 or polyvinylpyrrolidone (PVP) coated 15 nm Ag NPs to turbot, Scophthalmus maximus. Juvenile fish were exposed to the NPs through daily feeding for 14 days. The tested concentrations were 0, 0.75 or 1.5 mg of each NPs per kg of fish per day. The determination of NPs, Titanium and Ag levels (sp-ICP-MS/ICP-MS) and histological alterations (Transmission Electron Microscopy) supported proteomic analysis performed in the liver and kidney. Proteomic sample preparation procedure (SP3) was followed by LC-MS/MS. Label-free MS quantification methods were employed to assess differences in protein expression. Functional analysis was performed using STRING web-tool. KEGG Gene Ontology suggested terms were discussed and potential biomarkers of exposure were proposed. Overall, data shows that liver accumulated more elements than kidney, presented more histological alterations (lipid droplets counts and size) and proteomic alterations. The Differentially Expressed Proteins (DEPs) were higher in Ag NPs trial. The functional analysis revealed that both NPs caused enrichment of proteins related to generic processes (metabolic pathways). Ag NPs also affected protein synthesis and nucleic acid transcription, among other processes. Proteins related to thyroid hormone transport (Serpina7) and calcium ion binding (FAT2) were suggested as biomarkers of TiO2 NPs in liver. For Ag NPs, in kidney (and at a lower degree in liver) proteins related with metabolic activity, metabolism of exogenous substances and oxidative stress (e.g.: NADH dehydrogenase and Cytochrome P450) were suggested as potential biomarkers. Data suggests adverse effects in turbot after medium/lo, Funding: European Regional Development Fund (ERDF) through Interreg Atlantic Area Program, project NANO -CULTURE [EAPA 590/2018]; Portuguese Foundation for Science and Technology (Fundacao para a Ciencia e Tecnologia; FCT) [UIDB/04423/2020, UIDP/04423/2020]

Titanium dioxide (TiO2) and silver (Ag) NPs are among the most used engineered inorganic nanoparticles (NPs); however, their potential effects to marine demersal fish species, are not fully understood. Therefore, this study aimed to assess the proteomic alterations induced by sub-lethal concentrations citrate-coated 25 nm ("P25") TiO2 or polyvinylpyrrolidone (PVP) coated 15 nm Ag NPs to turbot, Scophthalmus maximus. Juvenile fish were exposed to the NPs through daily feeding for 14 days. The tested concentrations were 0, 0.75 or 1.5 mg of each NPs per kg of fish per day. The determination of NPs, Titanium and Ag levels (sp-ICP-MS/ICP-MS) and histological alterations (Transmission Electron Microscopy) supported proteomic analysis performed in the liver and kidney. Proteomic sample preparation procedure (SP3) was followed by LC-MS/MS. Label-free MS quantification methods were employed to assess differences in protein expression. Functional analysis was performed using STRING web-tool. KEGG Gene Ontology suggested terms were discussed and potential biomarkers of exposure were proposed. Overall, data shows that liver accumulated more elements than kidney, presented more histological alterations (lipid droplets counts and size) and proteomic alterations. The Differentially Expressed Proteins (DEPs) were higher in Ag NPs trial. The functional analysis revealed that both NPs caused enrichment of proteins related to generic processes (metabolic pathways). Ag NPs also affected protein synthesis and nucleic acid transcription, among other processes. Proteins related to thyroid hormone transport (Serpina7) and calcium ion binding (FAT2) were suggested as biomarkers of TiO2 NPs in liver. For Ag NPs, in kidney (and at a lower degree in liver) proteins related with metabolic activity, metabolism of exogenous substances and oxidative stress (e.g.: NADH dehydrogenase and Cytochrome P450) were suggested as potential biomarkers. Data suggests adverse effects in turbot after medium/lo, Funding: European Regional Development Fund (ERDF) through Interreg Atlantic Area Program, project NANO -CULTURE [EAPA 590/2018]; Portuguese Foundation for Science and Technology (Fundacao para a Ciencia e Tecnologia; FCT) [UIDB/04423/2020, UIDP/04423/2020]

Introdução: Fototerapia é a utilização da luz com finalidade terapêutica. Entre os recursos fototerapêuticos destaca-se o LED terapêutico utilizado na prática clínica fisioterapêutica, apresentando potencial efeito sobre o tratamento de afecções diversas. Estudos mostram que a terapia com LED é capaz de produzir efeitos anti-inflamatório, analgésico, estimulador e regenerador celular. No entanto são encontradas poucas evidências sobre os efeitos hipoalgésicos locais e a temperatura cutânea imediatamente após a aplicação do LED. Objetivo: Verificar os efeitos do LED terapêutico sobre a temperatura e o limiar de tolerância de dor à pressão (LTDP) em indivíduos saudáveis mediante termografia e algometria. Métodos: Trata-se de um ensaio clínico randomizado, aprovado pelo comitê de ética em pesquisa. Foram recrutadas 54 mulheres de 18 a 25 anos, randomizadas em três grupos: 1) Controle; 2) LED infravermelho 850nm e 3) LED vermelho 630nm. Os LEDs foram aplicados com fluência de 10J/cm2 durante 3 minutos no ventre do grupo muscular quadríceps direito. Para análise da temperatura cutânea, foi utilizada uma câmera de termografia, e o LTDP foi avaliado pelo algômetro. As avaliações ocorreram antes, imediatamente após e 5 minutos após à intervenção com o LED. Resultados: Os valores obtidos na termografia e algometria não evidenciaram alterações estatisticamente significativas sobre a temperatura e o LTDP, respectivamente, em nenhum dos três momentos avaliados. Conclusão: Os resultados sugerem que o LEDs vermelho e infravermelho, aplicados com fluência de 10J/cm2 durante 3 minutos, não alteram a temperatura e o LTDP em indivíduos saudáveis.

Titanium dioxide (TiO2) and silver (Ag) NPs are among the most used engineered inorganic nanoparticles (NPs); however, their potential effects to marine demersal fish species, are not fully understood. Therefore, this study aimed to assess the proteomic alterations induced by sub-lethal concentrations citrate-coated 25 nm ("P25") TiO2 or polyvinylpyrrolidone (PVP) coated 15 nm Ag NPs to turbot, Scophthalmus maximus. Juvenile fish were exposed to the NPs through daily feeding for 14 days. The tested concentrations were 0, 0.75 or 1.5 mg of each NPs per kg of fish per day. The determination of NPs, Titanium and Ag levels (sp-ICP-MS/ICP-MS) and histological alterations (Transmission Electron Microscopy) supported proteomic analysis performed in the liver and kidney. Proteomic sample preparation procedure (SP3) was followed by LC-MS/MS. Label-free MS quantification methods were employed to assess differences in protein expression. Functional analysis was performed using STRING web-tool. KEGG Gene Ontology suggested terms were discussed and potential biomarkers of exposure were proposed. Overall, data shows that liver accumulated more elements than kidney, presented more histological alterations (lipid droplets counts and size) and proteomic alterations. The Differentially Expressed Proteins (DEPs) were higher in Ag NPs trial. The functional analysis revealed that both NPs caused enrichment of proteins related to generic processes (metabolic pathways). Ag NPs also affected protein synthesis and nucleic acid transcription, among other processes. Proteins related to thyroid hormone transport (Serpina7) and calcium ion binding (FAT2) were suggested as biomarkers of TiO2 NPs in liver. For Ag NPs, in kidney (and at a lower degree in liver) proteins related with metabolic activity, metabolism of exogenous substances and oxidative stress (e.g.: NADH dehydrogenase and Cytochrome P450) were suggested as potential biomarkers. Data suggests adverse effects in turbot after medium/lo, Funding: European Regional Development Fund (ERDF) through Interreg Atlantic Area Program, project NANO -CULTURE [EAPA 590/2018]; Portuguese Foundation for Science and Technology (Fundacao para a Ciencia e Tecnologia; FCT) [UIDB/04423/2020, UIDP/04423/2020]

[Abstract] Cancer has a tremendous negative socio-economic impact on our society. Thus, the discovery of new and more effective anticancer drugs is of utmost importance. To address this societal challenge, the main goal of the CYANCAN project was the discovery of anticancer compounds from cyanobacteria. These photosynthetic bacteria are considered among the most promising groups capable of producing metabolites with pharmaceutical applications. A valuable and underexplored natural resource that can underpin the discovery of promising compounds can be found in the Blue Biotechnology and Ecotoxicology Culture Collection (LEGE-CC) at CIIMAR (Interdisciplinary Centre of Marine and Environmental Research), comprising more than 700 different cyanobacterial strains. Herein, we present the recent advances implemented for finding robust anticancer lead compounds from LEGE-CC cyanobacteria. For this purpose, we developed a natural product library. Sixty cyanobacterial strains, representative of LEGE-CC biodiversity, were chromatographed to yield 480 fractions that were tested for their cytotoxic activity against 2D and 3D models of human colon carcinoma (HCT 116). The conjugation of monolayer assays and 3D cancer spheroids led to the selection of 11 active fractions, of which the chemical space was studied using an untargeted metabolomics approach. The putative annotation and identification of several compounds led to the selection of two marine strains for compound isolation: Leptothoe sp. and Lusitaniella coriacea. The isolation of the compounds was guided through bioactivity assays and mass spectrometry. These molecules were purified from the crudes by employing several chromatography methods, and the chemical structures were determined by means of NMR (nuclear magnetic resonance) and MS/MS (tandem mass spectrometry) experiments. Thus, a novel macrolide-type compound was isolated from Leptothoe sp., which presented a highly cytotoxic activity against our cancer cell models

Since Desertification, par excellence,is a serious environmental problem of drylands, this study aims to analyze the susceptibility to Desertification in the Figueiredo River sub-basin, Ceará state, from the geobiophysical indicators of climate, relief and water resources. For this purpose, the geosystemic analysis in hydrographic basins and the geobiophysical indicators of Desertification by Abraham and Beekman (2006) adapted by Oliveira (2012) were adopted as a theoretical-methodological basis. As for the procedures adopted, a literature review, collection and analysis of secondary data, surveys and elaboration of cartographic products and fieldwork were carried out. The behavior of each indicator was investigated, together in the environmental systems of the sub-basin, indicating variations in susceptibility from low and from moderate to very high, Sendo a Desertificação, por excelência,um problema ambiental grave das terras secas, este estudo objetiva analisar a susceptibilidade à Desertificação na sub-bacia hidrográfica do Rio Figueiredo, estado do Ceará, a partir dos indicadores geobiofísicos de clima, relevo e recursos hídricos. Para tanto, adotou-se como base teórico-metodológica a análise geossistêmica em bacias hidrográficas e os indicadores geobiofísicos de Desertificação de Abraham e Beekman (2006) adaptados por Oliveira (2012). Quanto aos procedimentos adotados, realizou-se revisão de literatura, coleta e análise de dados secundários, levantamentos e elaboração de produtos cartográficos e trabalhos de campos. Averiguou-se o comportamento de cada indicador,em conjunto nos sistemas ambientais da sub-bacia, indicando variações à susceptibilidade baixo e de moderado a muito alto., Dado que la Desertificación, por excelencia, es ungrave problema ambiental en las tierras secas, este estudio tiene como objetivo analizar la susceptibilidad a la Desertificación en la subcuenca del río Figueiredo, estado de Ceará, a partir de indicadores geobiofísicos de clima, relieve y recursos hídricos. Para ello, se adoptó como base teórico-metodológica el análisis geosistémico en cuencas hidrográficas y los indicadores geobiofísicos de Desertificación de Abraham y Beekman (2006) adaptados por Oliveira (2012). En cuanto a los procedimientos adoptados, se realizó revisión bibliográfica, recolección y análisis de datos secundarios, levantamientos y elaboración de productos cartográficos y trabajo de campo. Se investigó el comportamiento de cada indicador, en conjunto en los sistemas ambientales de la subcuenca, indicando variaciones en la susceptibilidad de baja y de moderada a muy alta.

Titanium dioxide (TiO2) and silver (Ag) NPs are among the most used engineered inorganic nanoparticles (NPs); however, their potential effects to marine demersal fish species, are not fully understood. Therefore, this study aimed to assess the proteomic alterations induced by sub-lethal concentrations citrate-coated 25 nm ("P25") TiO2 or polyvinylpyrrolidone (PVP) coated 15 nm Ag NPs to turbot, Scophthalmus maximus. Juvenile fish were exposed to the NPs through daily feeding for 14 days. The tested concentrations were 0, 0.75 or 1.5 mg of each NPs per kg of fish per day. The determination of NPs, Titanium and Ag levels (sp-ICP-MS/ICP-MS) and histological alterations (Transmission Electron Microscopy) supported proteomic analysis performed in the liver and kidney. Proteomic sample preparation procedure (SP3) was followed by LC-MS/MS. Label-free MS quantification methods were employed to assess differences in protein expression. Functional analysis was performed using STRING web-tool. KEGG Gene Ontology suggested terms were discussed and potential biomarkers of exposure were proposed. Overall, data shows that liver accumulated more elements than kidney, presented more histological alterations (lipid droplets counts and size) and proteomic alterations. The Differentially Expressed Proteins (DEPs) were higher in Ag NPs trial. The functional analysis revealed that both NPs caused enrichment of proteins related to generic processes (metabolic pathways). Ag NPs also affected protein synthesis and nucleic acid transcription, among other processes. Proteins related to thyroid hormone transport (Serpina7) and calcium ion binding (FAT2) were suggested as biomarkers of TiO2 NPs in liver. For Ag NPs, in kidney (and at a lower degree in liver) proteins related with metabolic activity, metabolism of exogenous substances and oxidative stress (e.g.: NADH dehydrogenase and Cytochrome P450) were suggested as potential biomarkers. Data suggests adverse effects in turbot after medium/lo, Funding: European Regional Development Fund (ERDF) through Interreg Atlantic Area Program, project NANO -CULTURE [EAPA 590/2018]; Portuguese Foundation for Science and Technology (Fundacao para a Ciencia e Tecnologia; FCT) [UIDB/04423/2020, UIDP/04423/2020]

Titanium dioxide (TiO2) and silver (Ag) NPs are among the most used engineered inorganic nanoparticles (NPs); however, their potential effects to marine demersal fish species, are not fully understood. Therefore, this study aimed to assess the proteomic alterations induced by sub-lethal concentrations citrate-coated 25 nm ("P25") TiO2 or polyvinylpyrrolidone (PVP) coated 15 nm Ag NPs to turbot, Scophthalmus maximus. Juvenile fish were exposed to the NPs through daily feeding for 14 days. The tested concentrations were 0, 0.75 or 1.5 mg of each NPs per kg of fish per day. The determination of NPs, Titanium and Ag levels (sp-ICP-MS/ICP-MS) and histological alterations (Transmission Electron Microscopy) supported proteomic analysis performed in the liver and kidney. Proteomic sample preparation procedure (SP3) was followed by LC-MS/MS. Label-free MS quantification methods were employed to assess differences in protein expression. Functional analysis was performed using STRING web-tool. KEGG Gene Ontology suggested terms were discussed and potential biomarkers of exposure were proposed. Overall, data shows that liver accumulated more elements than kidney, presented more histological alterations (lipid droplets counts and size) and proteomic alterations. The Differentially Expressed Proteins (DEPs) were higher in Ag NPs trial. The functional analysis revealed that both NPs caused enrichment of proteins related to generic processes (metabolic pathways). Ag NPs also affected protein synthesis and nucleic acid transcription, among other processes. Proteins related to thyroid hormone transport (Serpina7) and calcium ion binding (FAT2) were suggested as biomarkers of TiO2 NPs in liver. For Ag NPs, in kidney (and at a lower degree in liver) proteins related with metabolic activity, metabolism of exogenous substances and oxidative stress (e.g.: NADH dehydrogenase and Cytochrome P450) were suggested as potential biomarkers. Data suggests adverse effects in turbot after medium/lo, Funding: European Regional Development Fund (ERDF) through Interreg Atlantic Area Program, project NANO -CULTURE [EAPA 590/2018]; Portuguese Foundation for Science and Technology (Fundacao para a Ciencia e Tecnologia; FCT) [UIDB/04423/2020, UIDP/04423/2020]

Liquid crystal polymer (LCP) has gained wide interest in the electronics industry largely due to its flexibility, stable insulation and dielectric properties and chip integration capabilities. Recently, LCP has also been investigated as a biocompatible substrate for the fabrication of multielectrode arrays. Realizing a fully implantable LCP-based bioelectronic device, however, still necessitates a low form factor packaging solution to protect the electronics in the body. In this work, we investigate two promising encapsulation coatings based on thin-film technology as the main packaging for LCP-based electronics. Specifically, a HfO2–based nanolaminate ceramic (TFE1) deposited via atomic layer deposition (ALD), and a hybrid Parylene C-ALD multilayer stack (TFE2), both with a silicone finish, were investigated and compared to a reference LCP coating. T-peel, water-vapour transmission rate (WVTR) and long-term electrochemical impedance spectrometry (EIS) tests were performed to evaluate adhesion, barrier properties and overall encapsulation performance of the coatings. Both TFE materials showed stable impedance characteristics while submerged in 60 °C saline, with TFE1-silicone lasting more than 16 months under a continuous 14V DC bias (experiment is ongoing). The results presented in this work show that WVTR is not the main factor in determining lifetime, but the adhesion of the coating to the substrate materials plays a key role in maintaining a stable interface and thus longer lifetimes., Bio-Electronics

A educação atual estabelece uma quebra de paradigmas para efetivar a inclusão de alunos da Educação Especial no ensino regular na perspectiva da Educação Inclusiva. Esse processo é desafiador para a escola e para os professores que têm alunos com deficiência. A pesquisa objetivou investigar quais as dificuldades e desafios enfrentados pelos professores nos Anos Finais do Ensino Fundamental com relação ao processo de inclusão de alunos com deficiência intelectual. Utilizou-se a metodologia qualitativa de caráter exploratório com aplicação de questionários e de entrevistas semiestruturadas. Como aporte teórico, são evidenciados os estudos de Mantoan (2003), Pletsch e Glat (2012), Oliveira (2017), Michel, (2005), Gil (1999), entre outros. Os resultados apontam que, apesar da necessidade de incluir os alunos com deficiência intelectual no ensino regular, os professores enfrentam dificuldades, como a ausência de formação voltada à inclusão, o processo de inclusão, conhecer os alunos de forma integral, escassez de recursos tecnológicos e a aprendizagem dos alunos com deficiência intelectual. Portanto, faz-se necessário um diálogo a respeito da escola inclusiva atual na busca de uma escola instrumentalizada, de um corpo docente preparado com linguagem, conceitos, valores e perspectiva do ensino no presente., Current education establishes a paradigm shift to effect the inclusion of special education students in regular education from the perspective of inclusive education. This process is challenging for the school and for teachers who have students with disabilities. The research aimed to investigate the difficulties and challenges faced by teachers in the Final Years of Elementary School in relation to the process of including students with intellectual disabilities. An exploratory qualitative methodology was used with the application of questionnaires and semi-structured interviews. As a theoretical contribution, studies by Mantoan (2003), Pletsch and Glat (2012), Oliveira (2017), Michel (2005), Gil (1999), among others, are highlighted. The results show that, despite the need to include students with intellectual disabilities in regular education, teachers face difficulties, such as the absence of training aimed at inclusion, the inclusion process, knowing students in an integral way, lack of technological resources and the learning of students with intellectual disabilities. Therefore, a dialogue about the current inclusive school is necessary in the search for an instrumented school, a faculty prepared with language, concepts, values and perspective of teaching in the present., La educación actual establece un cambio de paradigma para efectuar la inclusión de los estudiantes de educación especial en la educación regular desde la perspectiva de la educación inclusiva. Este proceso es desafiante para la escuela y para los maestros que tienen estudiantes con discapacidades. La investigación tuvo como objetivo indagar en las dificultades y desafíos que enfrentan los docentes de los últimos Años de la Enseñanza Fundamental en relación al proceso de inclusión de alumnos con discapacidad intelectual. Se utilizó una metodología cualitativa exploratoria con la aplicación de cuestionarios y entrevistas semiestructuradas. Como aporte teórico, se destacan los estudios de Mantoan (2003), Pletsch y Glat (2012), Oliveira (2017), Michel (2005), Gil (1999), entre otros. Los resultados muestran que, a pesar de la necesidad de incluir a los estudiantes con discapacidad intelectual en la educación regular, los docentes enfrentan dificultades, como la falta de formación orientada a la inclusión, el proceso de inclusión, el conocimiento integral de los estudiantes, la falta de recursos tecnológicos y la aprendizaje de los alumnos con discapacidad intelectual. Por tanto, es necesario un diálogo sobre la escuela inclusiva actual en la búsqueda de una escuela instrumentada, un profesorado preparado con lenguaje, conceptos, valores y perspectiva de la enseñanza en el presente.

Background: The lack of the recovery of CD4(+) T-cells (CD4(+) recovery) among immunodeficiency virus (HIV)-infected patients on antiretroviral therapy (ART) is not well known. We aimed to analyze the association between single nucleotide polymorphisms (SNPs) underlying vitamin D metabolism and the CD4(+) recovery in naive HIV-infected patients who started ART with low baseline CD4(+).Methods: We conducted a retrospective study in 411 naive individuals with plasma HIV load >200 copies/mL and CD4(+) <200 cells/mm(3). During 24 months of follow-up, all patients had plasma HIV load Results: CD4(+) recovery was higher in patients carrying DBP rs7041 AA genotype (AA versus CC/AC) and DHCR7 rs3829251 AA genotype (AA versus GG/AG) (p-value < 0.05). DBP rs7041 AA genotype was linked to increase in CD4(+) (adjusted arithmetic mean ratio (aAMR) = 1.22; q-value = 0.011), increase in CD4(+) >= P75th [adjusted odds ratio (aOR) = 2.31; q-value = 0.005], slope of CD4(+) recovery (aAMR = 1.25; q-value = 0.008), slope of CD4(+) recovery >= P75th (aOR = 2.55; q-value = 0.005) and achievement of CD4(+) >= 500 cells/mm(3) (aOR = 1.89; q-value = 0.023). Besides, DHCR7 rs3829251 AA genotype was related to increase in CD4(+) (aAMR = 1.43; q-value = 0.031), increase in CD4(+) >= P75th (aOR = 3.92; q-value = 0.030), slope of CD4(+) recovery (aAMR = 1.40; q-value = 0.036), slope of CD4(+) recovery >= P75th (aOR = 3.42; q-value = 0.031) and achievement of CD4(+) >= 500 cells/mm(3) (aOR = 5.68; q-value = 0.015).Conclusion: In summary, DHCR7 rs3829251 and DBP rs7041 polymorphisms were associated with CD4(+) recovery in HIV-infected patients who started cART with low CD4(+) T-cell counts.

Objective: To analyze the data on epidemiological records of autointoxication reports registered at a toxicological assistance center. Methods: Exploratory, descriptive, and retrospective study with the analysis of secondary data, conducted from the audit on Toxicological Occurrence Notification and Attendance forms, referring to the period from 2014 to 2018, filed in a toxicological information and assistance center, located in a municipality in southern Brazil. The data obtained were compiled in spreadsheets and analyzed using simple descriptive statistics. Results: 2,942 epidemiological records on women's autointoxication were audited, 72.0% of the total cases in the period studied. The predominant age group was 18 to 29 years old, with 1697 (57.7%) cases. The main toxic agent was medication, and the only agent of intoxication in 2,358 cases (80.1%). Psychotropic drugs accounted for 55.2% (1,593) of the cases, mainly antiepileptic and psychoanalytic drugs. Clonazepam was present in 567 (35.6%) suicide attempts and as the sole agent in 275 (17.3%) of them. In 873 cases (54.8%), mental illness was reported, in 546 (34.3%) previous suicide attempts, and 1,082 (67.9%) continued use of psychotropic medication. The main outcome was hospital discharge in 1,239 cases (77.8%). Conclusion: The study showed an increase in cases of female autointoxication over the period studied. The high percentage of autointoxication with psychotropic medications may be related to the ease of access at home and society's medicalization., Objetivo: Analisar os dados de fichas epidemiológicas de notificações de autointoxicação registradas em um centro de assistência toxicológica. Métodos: Estudo exploratório, descritivo e retrospectivo com análise de dados secundários, realizado a partir da auditoria em fichas de Notificação e de Atendimento de Ocorrências Toxicológicas, referentes ao período de 2014 a 2018, arquivadas em um centro de informação e assistência toxicológica, localizado em um município na região Sul do Brasil. Os dados obtidos foram compilados em planilhas e analisados por estatística descritiva simples. Resultados: Foram auditadas 2.942 fichas epidemiológicas de autointoxicação de mulheres, 72,0% do total de casos do período estudado. A faixa etária predominante foi de menor de 18 a 29 anos com 1697 (57,7%) casos. O principal agente tóxico foi o medicamento, como único agente da intoxicação em 2.358 casos (80,1%). Medicamentos psicotrópicos representaram 55,2% (1.593) dos casos, principalmente os antiepiléticos e psicoanalépticos. O clonazepam esteve presente em 567 (35,6%) tentativas de suicídio e como único agente em 275 (17,3%) delas. Em 873 casos (54,8%) foi informado transtorno mental, em 546 (34,3%) tentativa de suicídio anterior e 1.082 (67,9%) uso contínuo de medicação psicotrópica. O principal desfecho foi alta hospitalar em 1.239 casos (77,8%). Conclusão: O estudo apontou crescimento de casos de autointoxicação feminina ao longo do período estudado. A alta porcentagem de autointoxicação com medicamentos psicotrópicos pode estar relacionada com a facilidade de acesso nos domicílios e à medicalização da sociedade.

Objective: To analyze the data on epidemiological records of autointoxication reports registered at a toxicological assistance center. Methods: Exploratory, descriptive, and retrospective study with the analysis of secondary data, conducted from the audit on Toxicological Occurrence Notification and Attendance forms, referring to the period from 2014 to 2018, filed in a toxicological information and assistance center, located in a municipality in southern Brazil. The data obtained were compiled in spreadsheets and analyzed using simple descriptive statistics. Results: 2,942 epidemiological records on women's autointoxication were audited, 72.0% of the total cases in the period studied. The predominant age group was 18 to 29 years old, with 1697 (57.7%) cases. The main toxic agent was medication, and the only agent of intoxication in 2,358 cases (80.1%). Psychotropic drugs accounted for 55.2% (1,593) of the cases, mainly antiepileptic and psychoanalytic drugs. Clonazepam was present in 567 (35.6%) suicide attempts and as the sole agent in 275 (17.3%) of them. In 873 cases (54.8%), mental illness was reported, in 546 (34.3%) previous suicide attempts, and 1,082 (67.9%) continued use of psychotropic medication. The main outcome was hospital discharge in 1,239 cases (77.8%). Conclusion: The study showed an increase in cases of female autointoxication over the period studied. The high percentage of autointoxication with psychotropic medications may be related to the ease of access at home and society's medicalization., Objetivo: Analisar os dados de fichas epidemiológicas de notificações de autointoxicação registradas em um centro de assistência toxicológica. Métodos: Estudo exploratório, descritivo e retrospectivo com análise de dados secundários, realizado a partir da auditoria em fichas de Notificação e de Atendimento de Ocorrências Toxicológicas, referentes ao período de 2014 a 2018, arquivadas em um centro de informação e assistência toxicológica, localizado em um município na região Sul do Brasil. Os dados obtidos foram compilados em planilhas e analisados por estatística descritiva simples. Resultados: Foram auditadas 2.942 fichas epidemiológicas de autointoxicação de mulheres, 72,0% do total de casos do período estudado. A faixa etária predominante foi de menor de 18 a 29 anos com 1697 (57,7%) casos. O principal agente tóxico foi o medicamento, como único agente da intoxicação em 2.358 casos (80,1%). Medicamentos psicotrópicos representaram 55,2% (1.593) dos casos, principalmente os antiepiléticos e psicoanalépticos. O clonazepam esteve presente em 567 (35,6%) tentativas de suicídio e como único agente em 275 (17,3%) delas. Em 873 casos (54,8%) foi informado transtorno mental, em 546 (34,3%) tentativa de suicídio anterior e 1.082 (67,9%) uso contínuo de medicação psicotrópica. O principal desfecho foi alta hospitalar em 1.239 casos (77,8%). Conclusão: O estudo apontou crescimento de casos de autointoxicação feminina ao longo do período estudado. A alta porcentagem de autointoxicação com medicamentos psicotrópicos pode estar relacionada com a facilidade de acesso nos domicílios e à medicalização da sociedade.

Objective: To analyze the data on epidemiological records of autointoxication reports registered at a toxicological assistance center. Methods: Exploratory, descriptive, and retrospective study with the analysis of secondary data, conducted from the audit on Toxicological Occurrence Notification and Attendance forms, referring to the period from 2014 to 2018, filed in a toxicological information and assistance center, located in a municipality in southern Brazil. The data obtained were compiled in spreadsheets and analyzed using simple descriptive statistics. Results: 2,942 epidemiological records on women's autointoxication were audited, 72.0% of the total cases in the period studied. The predominant age group was 18 to 29 years old, with 1697 (57.7%) cases. The main toxic agent was medication, and the only agent of intoxication in 2,358 cases (80.1%). Psychotropic drugs accounted for 55.2% (1,593) of the cases, mainly antiepileptic and psychoanalytic drugs. Clonazepam was present in 567 (35.6%) suicide attempts and as the sole agent in 275 (17.3%) of them. In 873 cases (54.8%), mental illness was reported, in 546 (34.3%) previous suicide attempts, and 1,082 (67.9%) continued use of psychotropic medication. The main outcome was hospital discharge in 1,239 cases (77.8%). Conclusion: The study showed an increase in cases of female autointoxication over the period studied. The high percentage of autointoxication with psychotropic medications may be related to the ease of access at home and society's medicalization., Objetivo: Analisar os dados de fichas epidemiológicas de notificações de autointoxicação registradas em um centro de assistência toxicológica. Métodos: Estudo exploratório, descritivo e retrospectivo com análise de dados secundários, realizado a partir da auditoria em fichas de Notificação e de Atendimento de Ocorrências Toxicológicas, referentes ao período de 2014 a 2018, arquivadas em um centro de informação e assistência toxicológica, localizado em um município na região Sul do Brasil. Os dados obtidos foram compilados em planilhas e analisados por estatística descritiva simples. Resultados: Foram auditadas 2.942 fichas epidemiológicas de autointoxicação de mulheres, 72,0% do total de casos do período estudado. A faixa etária predominante foi de menor de 18 a 29 anos com 1697 (57,7%) casos. O principal agente tóxico foi o medicamento, como único agente da intoxicação em 2.358 casos (80,1%). Medicamentos psicotrópicos representaram 55,2% (1.593) dos casos, principalmente os antiepiléticos e psicoanalépticos. O clonazepam esteve presente em 567 (35,6%) tentativas de suicídio e como único agente em 275 (17,3%) delas. Em 873 casos (54,8%) foi informado transtorno mental, em 546 (34,3%) tentativa de suicídio anterior e 1.082 (67,9%) uso contínuo de medicação psicotrópica. O principal desfecho foi alta hospitalar em 1.239 casos (77,8%). Conclusão: O estudo apontou crescimento de casos de autointoxicação feminina ao longo do período estudado. A alta porcentagem de autointoxicação com medicamentos psicotrópicos pode estar relacionada com a facilidade de acesso nos domicílios e à medicalização da sociedade.

INTRODUCTION: The first wave of COVID-19 pandemic has disrupted almost all areas of the health care services to some extent throughout the world. Although the negative impact of COVID-19 on patients with autoimmune diseases has also been recognized, available data in this regard are limited. In the current study of the European Autoimmunity Standardisation Initiative (EASI) we aimed to provide reliable data on the extent of the impact of COVID-19 pandemic on test requests for different autoantibodies in European countries.METHODS: Data on test numbers and on the number of positive results were collected in 97 clinical laboratories from 15 European countries on a monthly basis for the year before (2019) and the year during (2020) the COVID-19 pandemic.RESULTS: A reduction in the number of autoantibody tests was observed in all European countries in the year 2020 compared to 2019. The reduction affected all autoantibody tests with an overall decrease of 13%, ranging from 1.4% (Switzerland) to 25.5% (Greece). In all countries, the decrease was most pronounced during the first wave of the pandemic (March-May 2020) with an overall decrease in those three months of 45.2%. The most affected autoantibodies were those commonly requested by general practitioners (anti-tTG IgA (-71%), RF IgM (-66%) and ACPA (-61%)). In the second wave of the pandemic (October-December 2020) the decrease was less pronounced (6.8%). With respect to the rate of positive results, subtle differences were observed for distinct autoantibodies during the pandemic, but the total rate of positive results was similar in both years.CONCLUSIONS: Our study demonstrated a strong decrease in autoantibody requests during the first wave of the COVID-19 pandemic in 15 European countries. The second wave was characterized by a less pronounced impact, with some participating countries hardly affected, while some other countries experienced a second decline. The decrease was clearly associat

Describir los impactos en la salud mental de los profesionales de la salud ante la pandemia del COVID-19. Estudio de revisión integradora de la literatura, búsqueda de artículos en las bases de datos LILACS, SciELO, MEDLINE, SciVerse Scopus publicadas en 2020. Se encontraron 169 artículos, de los cuales 18 cumplieron con los criterios de elegibilidad. Los impactos más prevalentes en la salud mental para los profesionales de la salud debido a la pandemia de COVID-19 fueron la ansiedad, la depresión, seguidas de los sentimientos de miedo, estrés e insomnio. Las enfermeras son los profesionales sanitarios más afectados seguidos por los médicos. Los profesionales de la salud viven un momento único debido a la pandemia de COVID-19, en el que su salud mental ha sido una preocupación. Se sugieren estudios para una mayor visibilidad de los problemas colaborativos por enfermedad en la salud mental de los profesionales, su importancia y la alta tasa de causar daño a la integridad mental, que puede ser de corto a largo plazo., To describe the impacts on the mental health of health professionals in the face of the pandemic by COVID-19. An integrative literature review study, searching for articles in the LILACS, SciELO, MEDLINE, SciVerse Scopus databases published in 2020. 169 articles were found, of which 18 met the eligibility criteria. The most prevalent impacts on mental health for health professionals due to the COVID-19 pandemic were anxiety, depression, followed by feelings of fear, stress and insomnia. Nurses are the most affected health professionals followed by doctors. Health professionals experience a unique moment due to the COVID-19 pandemic, in which their mental health has been a concern. Studies are suggested to increase the visibility of collaborative problems for illness in mental health of professionals, their importance and the high rate of causing damage to mental integrity, which may be in effect in the short to long term., Descrever os impactos à saúde mental dos profissionais da saúde frente à pandemia pela COVID-19. Estudo do tipo revisão integrativa da literatura, com busca dos artigos nas bases de dados LILACS, SciELO, MEDLINE, SciVerse Scopus publicados em 2020. Foram encontrados 169 artigos, dos quais, 18 atenderam os critérios de elegibilidade. Os impactos à saúde mental aos profissionais da saúde pela pandemia por COVID-19 mais predominantes foram a ansiedade, depressão, seguidos de sensação de medo, estresse e insônia. Os enfermeiros são os profissionais de saúde mais afetados seguidos dos médicos. Os profissionais de saúde vivenciam um momento ímpar decorrente da pandemia da COVID-19, em que a saúde mental destes tem sido preocupante. Sugere-se estudos para maior visibilidade aos problemas colaborativos para adoecimento em saúde mental dos profissionais, sua importância e o elevado índice de causar prejuízos à integridade mental, podendo vigorar de curto para um longo prazo.

Proteomics has been recently introduced in aquaculture research, and more methodological studies are needed to improve the quality of proteomics studies. Therefore, this work aims to compare three sample preparation methods for shotgun LC-MS/MS proteomics using tissues of two aquaculture species: liver of turbot Scophthalmus maximus and hepatopancreas of Mediterranean mussel Mytilus galloprovincialis. We compared the three most common sample preparation workflows for shotgun analysis: filter-aided sample preparation (FASP), suspension-trapping (S-Trap), and solid-phase-enhanced sample preparations (SP3). FASP showed the highest number of protein identifications for turbot samples, and S-Trap outperformed other methods for mussel samples. Subsequent functional analysis revealed a large number of Gene Ontology (GO) terms in turbot liver proteins (nearly 300 GO terms), while fewer GOs were found in mussel proteins (nearly 150 GO terms for FASP and S-Trap and 107 for SP3). This result may reflect the poor annotation of the genomic information in this specific group of animals. FASP was confirmed as the most consistent method for shotgun proteomic studies; however, the use of the other two methods might be important in specific experimental conditions (e.g., when samples have a very low amount of protein)., Funding Agencies|European Union (Interreg POCTEP, project ACUINANO) [07-12-ACUINANO_1_E]; Portuguese Foundation for Science and Technology (Fundacao para a Ciencia e Tecnologia; FCT)Portuguese Foundation for Science and Technology [UIDB/04423/2020, UIDP/04423/2020]; European Regional Development Fund (ERDF)European Commission

Proteomics has been recently introduced in aquaculture research, and more methodological studies are needed to improve the quality of proteomics studies. Therefore, this work aims to compare three sample preparation methods for shotgun LC-MS/MS proteomics using tissues of two aquaculture species: liver of turbot Scophthalmus maximus and hepatopancreas of Mediterranean mussel Mytilus galloprovincialis. We compared the three most common sample preparation workflows for shotgun analysis: filter-aided sample preparation (FASP), suspension-trapping (S-Trap), and solid-phase-enhanced sample preparations (SP3). FASP showed the highest number of protein identifications for turbot samples, and S-Trap outperformed other methods for mussel samples. Subsequent functional analysis revealed a large number of Gene Ontology (GO) terms in turbot liver proteins (nearly 300 GO terms), while fewer GOs were found in mussel proteins (nearly 150 GO terms for FASP and S-Trap and 107 for SP3). This result may reflect the poor annotation of the genomic information in this specific group of animals. FASP was confirmed as the most consistent method for shotgun proteomic studies; however, the use of the other two methods might be important in specific experimental conditions (e.g., when samples have a very low amount of protein)., Funding Agencies|European Union (Interreg POCTEP, project ACUINANO) [07-12-ACUINANO_1_E]; Portuguese Foundation for Science and Technology (Fundacao para a Ciencia e Tecnologia; FCT)Portuguese Foundation for Science and Technology [UIDB/04423/2020, UIDP/04423/2020]; European Regional Development Fund (ERDF)European Commission

This article belongs to the Special Issue Managerial and Entrepreneurial Decision Making: Emerging Issues.

Since the conceptualization of bounded rationality by Herbert Simon (1947), man-agement scholars started investigating how people—managers and entrepreneurs—reallymake decisions within (and for) organizations. Taking into considerations the effect onorganizational choices (e.g., new product development, market entry, merger and/or ac-quisition of other entities) and related performance (in organizational, economic, and socialterms), a series of trends have flourished within this pivotal research area. Nowadays, themain important are: the biasing or beneficial role of heuristics (i.e., cognitive shortcuts ofhuman mind) (Kahneman 2003), the influence of socio-demographic characteristics andpersonality traits (see the derived Upper Echelons Theory; Hambrick and Mason 1984;Abatecola and Cristofaro 2020), the impact of affective states (e.g., emotions, mood, temper-ament), the intertwinement between cognitive and emotional factors, the co-determinantrole of the (micro-, meso-, and macro-) environment in the formation of choices withperson-, group-, firm-specific variables, and the biasing or beneficial impact of technologieson managers’ and entrepreneurs’ rationality.

Este artículo busca reflexionar sobre el silenciamiento al que estaba destinada la militancia femenina dentro del Partido Comunista de Brasil y en las páginas de la historiografía producida por militantes de esta organización. A través de esta perspectiva, piense cómo algunas dirigentes del PCB elaboraron sus concepciones sobre la militancia femenina y cómo recordaron sus trayectorias políticas. Esencialmente, preguntamos por el olvido al que las mujeres activistas fueron relegadas por sus compañeras, especialmente en lo que respecta a la memoria del partido, en un intento de problematizar temas que parte de la historiografía insiste en hacer irrelevantes, secundarios e innecesarios., O presente artigo busca refletir acerca do silenciamento a que foi destinada a militância feminina no interior do Partido Comunista do Brasil e nas páginas da historiografia produzida por militantes desta organização. Através dessa perspectiva, pensar como algumas lideranças do PCB elaboraram suas concepções sobre a militância feminina e como rememoraram suas trajetórias politicas. Essencialmente indagamos sobre o esquecimento a que foram relegadas as mulheres militantes por seus companheiros, sobretudo no que diz respeito à memória do partido, na tentativa de problematizar questões ainda não enfocadas por parte da historiografia sobre o movimento operário., This article seeks to reflect on the silencing to which female militancy was destined within the Communist Party of Brazil and on the pages of the historiography produced by militants of this organization. Through this perspective, think about how some leaders of the PCB elaborated their conceptions about the female militancy and how they remembered their political trajectories. Essentially, we asked about the forgetfulness to which women activists were relegated by their companions, especially with regard to the party's memory, in an attempt to problematize issues that part of historiography insists on making irrelevant, secondary and unnecessary.

Since the conceptualization of bounded rationality by Herbert Simon (1947), man-agement scholars started investigating how people—managers and entrepreneurs—reallymake decisions within (and for) organizations. Taking into considerations the effect onorganizational choices (e.g., new product development, market entry, merger and/or ac-quisition of other entities) and related performance (in organizational, economic, and socialterms), a series of trends have flourished within this pivotal research area. Nowadays, themain important are: the biasing or beneficial role of heuristics (i.e., cognitive shortcuts ofhuman mind) (Kahneman 2003), the influence of socio-demographic characteristics andpersonality traits (see the derived Upper Echelons Theory; Hambrick and Mason 1984;Abatecola and Cristofaro 2020), the impact of affective states (e.g., emotions, mood, temper-ament), the intertwinement between cognitive and emotional factors, the co-determinantrole of the (micro-, meso-, and macro-) environment in the formation of choices withperson-, group-, firm-specific variables, and the biasing or beneficial impact of technologieson managers’ and entrepreneurs’ rationality.

This article aims to highlight and understand movements in the collaboration process as a methodology for the initial education of mathematics teachers in teaching initiation spaces. To this end, a qualitative interpretative investigation was carried out using the triangulation of national documents and studies and a training action of a Brazilian federal university (UFSCar) on mathematics teachers and the beginning of teaching. The analysis appropriated concepts that involve processes of reflection, investigation, partnership and collaboration for the professional development of teachers. The results showed that the collaborative movements became a methodology for initial teacher training when considering and valuing a longitudinal process of: co-education among all involved; dialogues and negotiations in planning, developing and evaluating teaching practices; institutional intentions and engagements and reflective and investigative practices and writings in/from the lived education process., Este artigo tem como objetivo evidenciar e compreender movimentos do processo de colaboração, enquanto metodologia de formação inicial de professores de matemática em espaços de iniciação à docência. Para isso, foi realizada uma investigação qualitativa interpretativa, com a utilização da triangulação de documentos, de estudos nacionais e de uma ação de formação de professores de matemática e iniciação à docência de uma universidade federal brasileira (UFSCar). A análise se apropriou de conceitos que envolvem processos de reflexão, investigação, parceria e colaboração para o desenvolvimento profissional docente. Os resultados evidenciam que os movimentos de colaboração se tornaram uma metodologia de formação inicial de professores ao considerar e valorizar um processo longitudinal de: co-formação entre todos os envolvidos; diálogos e negociações no planejar, desenvolver e avaliar as práticas docentes; intencionalidades e engajamentos institucionais e práticas e escritas reflexivas e investigativas no/do processo de formação vivido., Este artículo tiene como objetivo destacar y comprender los movimientos en el proceso de colaboración como metodología para la formación inicial de los profesores de matemáticas en los espacios de iniciación docente. Para ello, se realizó una investigación interpretativa cualitativa utilizando la triangulación de documentos y estudios nacionales y una universidad federal brasileña (UFSCar) sobre la formación de profesores de matemáticas y el inicio de la docencia. El análisis se apropió de conceptos que involucran procesos de reflexión, investigación, asociación y colaboración para el desarrollo profesional de los docentes. Los resultados mostraron que los movimientos colaborativos se convirtieron en una metodología de formación inicial docente al considerar y valorar un proceso longitudinal de: co-formación entre todos los involucrados; diálogos y negociaciones en la planificación, desarrollo y evaluación de prácticas docentes; intenciones y compromisos institucionales y prácticas y escritos reflexivos e investigativos en/desde el proceso de formación vivido.

Objective: To describe the consequences of using artificial nipples to exclusive breastfeeding. Materials and method: An integrative review carried out in the Medline®, Cinahl, Lilacs, Web of Science, and Scopus databases to answer the following question: What are the consequences of using artificial nipples to exclusive breastfeeding? Results: 38 articles were analyzed; the analysis gave rise to two categories: neonatal factors and maternal factors influencing exclusive breastfeeding. Breastfeeding interruption was the neonatal factor most associated with the use of artificial nipples, while the level of maternal education stood out as an intervening factor in exclusive breastfeeding. Pacifiers were the dummy type more commonly mentioned, followed by feeding bottles and nipple shields. Conclusions: The consequences of offering artificial nipples to breastfed infants are mostly negative and associated with the newborn, such as early weaning, refusal to breastfeed, impaired suction technique, incorrect latch-on, interference with orofacial development, and interruption of exclusive breastfeeding. Mothers who offered artificial nipples to their infants are more likely to experience pain, nipple fissures, frustration, and reduced interaction with their infants., Objetivo: descrever as consequências do uso de bicos artificiais para a amamentação exclusiva. Materiais e método: revisão integrativa realizada nas bases de dados Medline®, Cinahl, Lilacs, Web of Science e Scopus para responder à seguinte questão: qual a influência que a oferta de bicos artificiais aos recém-nascidos exerce na amamentação? Resultados: foram analisados 38 artigos; a análise deu origem a duas categorias: fatores neonatais e fatores maternos de influência na amamentação exclusiva. A interrupção do aleitamento materno foi o fator neonatal mais relacionado ao uso de bicos artificiais, enquanto o nível de escolaridade materno destacou-se como fator interveniente na amamentação exclusiva. A chupeta foi o bico artificial mais encontrado citado, seguido da mamadeira e do protetor mamilar. Conclusões: as consequências da oferta de bicos artificiais às crianças em amamentação são, em sua maioria, negativas e relacionadas ao neonato, como o desmame precoce, a recusa do peito, a sucção prejudicada, a pega incorreta, a interferência no desenvolvimento orofacial e a interrupção do aleitamento materno exclusivo. As mães que ofereceram bicos artificiais aos seus filhos estão mais propensas a ter dor, fissura mamilar, frustração e redução da interação com seu filho., Objetivo: describir las consecuencias del uso de picos artificiales para la lactancia exclusiva. Materiales y método: revisión integradora realizada en las bases de datos Medline®, Cinahl, Lilacs, Web of Science e Scopus para contestar a la siguiente cuestión: ¿cuál es la influencia que ejerce en la lactancia la oferta de picos artificiales a los recién nacidos? Resultados: se analizaron 38 artículos; el análisis originó dos categorías: factores neonatales y factores maternos de influencia en la lactancia exclusiva. La interrupción de la lactancia materna fue el factor neonatal más asociado al uso de picos artificiales, mientras el nivel de escolaridad materno se destacó como factor interviniente en la lactancia exclusiva. El chupo fue el pico artificial más encontrado citado, seguido del biberón y del protector mamilar. Conclusiones: las consecuencias de la oferta de picos artificiales a los bebés em la lactancia son, en su mayoría, negativas y relacionadas con el neonato, como el desmame temprano y el rechazo al seno, la succión perjudicada, el agarre inadecuado, la interferencia en el desarrollo orofacial y la interrupción de la lactancia materna exclusiva. Las madres que ofrecieron picos artificiales a sus hijos están más propensas a sentir dolor, tener fisura mamilar, frustración y reducción de la interacción con su hijo.

Proteomics has been recently introduced in aquaculture research, and more methodological studies are needed to improve the quality of proteomics studies. Therefore, this work aims to compare three sample preparation methods for shotgun LC-MS/MS proteomics using tissues of two aquaculture species: liver of turbot Scophthalmus maximus and hepatopancreas of Mediterranean mussel Mytilus galloprovincialis. We compared the three most common sample preparation workflows for shotgun analysis: filter-aided sample preparation (FASP), suspension-trapping (S-Trap), and solid-phase-enhanced sample preparations (SP3). FASP showed the highest number of protein identifications for turbot samples, and S-Trap outperformed other methods for mussel samples. Subsequent functional analysis revealed a large number of Gene Ontology (GO) terms in turbot liver proteins (nearly 300 GO terms), while fewer GOs were found in mussel proteins (nearly 150 GO terms for FASP and S-Trap and 107 for SP3). This result may reflect the poor annotation of the genomic information in this specific group of animals. FASP was confirmed as the most consistent method for shotgun proteomic studies; however, the use of the other two methods might be important in specific experimental conditions (e.g., when samples have a very low amount of protein)., Funding Agencies|European Union (Interreg POCTEP, project ACUINANO) [07-12-ACUINANO_1_E]; Portuguese Foundation for Science and Technology (Fundacao para a Ciencia e Tecnologia; FCT)Portuguese Foundation for Science and Technology [UIDB/04423/2020, UIDP/04423/2020]; European Regional Development Fund (ERDF)European Commission

Since the conceptualization of bounded rationality by Herbert Simon (1947), man-agement scholars started investigating how people—managers and entrepreneurs—reallymake decisions within (and for) organizations. Taking into considerations the effect onorganizational choices (e.g., new product development, market entry, merger and/or ac-quisition of other entities) and related performance (in organizational, economic, and socialterms), a series of trends have flourished within this pivotal research area. Nowadays, themain important are: the biasing or beneficial role of heuristics (i.e., cognitive shortcuts ofhuman mind) (Kahneman 2003), the influence of socio-demographic characteristics andpersonality traits (see the derived Upper Echelons Theory; Hambrick and Mason 1984;Abatecola and Cristofaro 2020), the impact of affective states (e.g., emotions, mood, temper-ament), the intertwinement between cognitive and emotional factors, the co-determinantrole of the (micro-, meso-, and macro-) environment in the formation of choices withperson-, group-, firm-specific variables, and the biasing or beneficial impact of technologieson managers’ and entrepreneurs’ rationality.

Describir los impactos en la salud mental de los profesionales de la salud ante la pandemia del COVID-19. Estudio de revisión integradora de la literatura, búsqueda de artículos en las bases de datos LILACS, SciELO, MEDLINE, SciVerse Scopus publicadas en 2020. Se encontraron 169 artículos, de los cuales 18 cumplieron con los criterios de elegibilidad. Los impactos más prevalentes en la salud mental para los profesionales de la salud debido a la pandemia de COVID-19 fueron la ansiedad, la depresión, seguidas de los sentimientos de miedo, estrés e insomnio. Las enfermeras son los profesionales sanitarios más afectados seguidos por los médicos. Los profesionales de la salud viven un momento único debido a la pandemia de COVID-19, en el que su salud mental ha sido una preocupación. Se sugieren estudios para una mayor visibilidad de los problemas colaborativos por enfermedad en la salud mental de los profesionales, su importancia y la alta tasa de causar daño a la integridad mental, que puede ser de corto a largo plazo., To describe the impacts on the mental health of health professionals in the face of the pandemic by COVID-19. An integrative literature review study, searching for articles in the LILACS, SciELO, MEDLINE, SciVerse Scopus databases published in 2020. 169 articles were found, of which 18 met the eligibility criteria. The most prevalent impacts on mental health for health professionals due to the COVID-19 pandemic were anxiety, depression, followed by feelings of fear, stress and insomnia. Nurses are the most affected health professionals followed by doctors. Health professionals experience a unique moment due to the COVID-19 pandemic, in which their mental health has been a concern. Studies are suggested to increase the visibility of collaborative problems for illness in mental health of professionals, their importance and the high rate of causing damage to mental integrity, which may be in effect in the short to long term., Descrever os impactos à saúde mental dos profissionais da saúde frente à pandemia pela COVID-19. Estudo do tipo revisão integrativa da literatura, com busca dos artigos nas bases de dados LILACS, SciELO, MEDLINE, SciVerse Scopus publicados em 2020. Foram encontrados 169 artigos, dos quais, 18 atenderam os critérios de elegibilidade. Os impactos à saúde mental aos profissionais da saúde pela pandemia por COVID-19 mais predominantes foram a ansiedade, depressão, seguidos de sensação de medo, estresse e insônia. Os enfermeiros são os profissionais de saúde mais afetados seguidos dos médicos. Os profissionais de saúde vivenciam um momento ímpar decorrente da pandemia da COVID-19, em que a saúde mental destes tem sido preocupante. Sugere-se estudos para maior visibilidade aos problemas colaborativos para adoecimento em saúde mental dos profissionais, sua importância e o elevado índice de causar prejuízos à integridade mental, podendo vigorar de curto para um longo prazo.