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Objectives: We validated a screening protocol in which thoracic ultrasound (TUS) acts as a first-line complementary imaging technique in selecting patients which may deserve a second-line low-dose high resolution computed tomography (HRCT) scan among a population of asymptomatic high-risk subjects for interstitial lung abnormalities (ILA) and lung cancer. Due to heavy environmental pollution burden, the district Tamburi of Taranto has been chosen as “case study” for this purpose. Methods: From July 2018 to October 2020, 677 patients aged between 45 and 65 year and who had been living in the Tamburi district of Taranto for at least 10 years were included in the study. After demographic, clinical and risk factor exposition data were collected, each participant underwent a complete TUS examination. These subjects were then asked to know if they agreed to perform a second-level examination by low-dose HRCT scan. Results: On a total of 167 subjects (24.7%) who agreed to undergo a second-level HRCT, 85 patients (50.9%) actually showed pleuro-pulmonary abnormalities. Interstitial abnormalities were detected in a total of 36 patients on HRCT scan. In particular, 34 participants presented subpleural ILAs, that were classified in the fibrotic subtype in 7 cases. The remaining 2 patients showed non-subpleural interstitial abnormalities. Subpleural nodules were observed in 46 patients. TUS showed an overall diagnostic accuracy of 88.6% in detecting pleuro-pulmonary abnormalities in comparison with HRCT scan, with a sensitivity of 95.3%, a specificity of 81.7%, a positive predictive value of 84.4% and a negative predictive value of 94.4%. The matched evaluation of specific pulmonary abnormalities on HRTC scan (i.e., interstitial abnormalities or pulmonary nodules) with determinate sonographic findings revealed a reduction in both TUS sensibility and specificity. Focusing TUS evaluation on the assessment of interstitial abnormalities, a thickened pleural line showed a sensitivity

Introduction: There is, so far, no universal definition of severe asthma. This definition usually relies on: number of exacerbations, inhaled therapy, need for oral corticosteroids, and respiratory function. The use of such parameters varies in the different definitions used. Thus, according to the parameters chosen, each patient may result in having severe asthma or not. The aim of this study was to evaluate how the choice of a specific definition of severe asthma can change the allocation of patients. Methods: Data collected from the Severe Asthma Network Italy (SANI) registry were analyzed. All the patients included were then reclassified according to the definitions of U-BIOPRED, NICE, WHO, ATS/ERS, GINA, ENFUMOSA, and TENOR. Results: 540 patients, were extracted from the SANI database. We observed that 462 (86%) met the ATS/ERS criteria as well as the GINA criteria, 259 (48%) the U-Biopred, 222 (41%) the NICE, 125 (23%) the WHO, 313 (58%) the Enfumosa, and 251 (46%) the TENOR criteria. The mean eosinophil value were similar in the ATS/ERS, U-Biopred, and Enfumosa (528, 532 and 516 cells/mcl), higher in WHO and Tenor (567 and 570 cells/mcl) and much higher in the NICE classification (624 cells/mcl). Lung function tests resulted similarly in all groups, with WHO (67%) and ATS/ERS-GINA (73%), respectively, showing the lower and upper mean FEV1 values. Conclusions: The present observations clearly evidence the heterogeneity in the distribution of patients when different definitions of severe asthma are used. However, the recent definition of severe asthma, provided by the GINA document, is similar to that indicated in 2014 by ATS/ERS, allowing mirror reclassification of the patients examined. This lack of homogeneity could complicate the access to biological therapies. The definition provided by the GINA document, which reflects what suggested by ATS/ERS, could partially overcome the problem.

Background and aims: Severe asthma is burdened by frequent exacerbations and use of oral corticosteroids (OCS) which worsen patients’ health and increase healthcare spending. Aim of this study was to assess the clinical and economic effect of adding mepolizumab (MEP) for the treatment of these patients. Methods: Patients >18 years old, referred to 8 asthma clinics, starting MEP between May 2017 and December 2018, were enrolled and followed-up for 12 months. Information in the 12 months before mepolizumab were collected retrospectively. The evaluation parameters included: OCS use, number of exacerbations/hospitalizations, concomitant therapies, comorbidity, and annual number of working days lost due to the disease. The primary objective was to compare the annual total cost per patient pre- and post-MEP. Secondary outcomes included rates of exacerbations and number of OCS-dependent patients. Results: 106 patients were enrolled in the study: 46 male, median age 58 years. Mean annual cost pre- and post-MEP (cost of biologic excluded) was €3996 and €1,527, respectively. Total savings due to MEP resulted in €2469 (95%CI 1945–2993), 62% due to exacerbations reduction and 33% due to productivity increase. Such savings could fund about 22% of the total cost of MEP for one year. The introduction of MEP induced a clinical benefit by reducing both OCS-dependent patients (OR = 0.12, 95%CI 0.06–0.23) and exacerbation rate (RR = 0.19, 95%CI 0.15–0.24). Conclusions: Patients with severe eosinophilic asthma experienced a clinical benefit in asthma control adding MEP to standard therapy. Biologic therapy can be, partially, funded by the savings produced by patients’ improvement.

Neutrino decay has been proposed as a possible solution to the atmospheric neutrino anomaly, in the light of the recent data from the Super-Kamiokande experiment. We investigate this hypothesis by means of a quantitative analysis of the zenith angle distributions of neutrino events in Super-Kamiokande, including the latest (45 kTy) data. We find that the neutrino decay hypothesis fails to reproduce the observed distributions of muons., Comment: 6 pages (RevTeX) + 2 figures (Postscript)

The recent observations of atmospheric nu events from the Super-Kamiokande experiment are compatible with three-flavor neutrino oscillations, occurring dominantly in the nu_mu<--->nu_tau channel and subdominantly in the nu_mu<--->nu_e channel. We present an updated analysis of the three-flavor mass-mixing parameters consistent with the present phenomenology, including the latest 45 kTy data sample from Super-Kamiokande. A comparison with our previous results, based on 33 kTy data, shows that the oscillation evidence is strengthened, and that the neutrino mass-mixing parameters are constrained in smaller ranges., Comment: 5 pages, 3 figures. Presented at WIN99. Updated analysis including 45 kTy Super-Kamiokande data

The evidence for $\nu_\mu$ disappearance in the Super-Kamiokande atmospheric neutrino experiment and the negative searches for $\nu_e$ disappearance in the CHOOZ reactor experiment can be easily reconciled by assuming oscillations with large amplitude in the $\nu_\mu\leftrightarrow\nu_\tau$ channel and small (or null) amplitude in the $\nu_\mu\leftrightarrow\nu_e$ channel. It has been claimed, however, that some oscillation scenarios with large $\nu_\mu\leftrightarrow\nu_e$ mixing can also be constructed in agreement with the present data. We investigate quantitatively two such scenarios: (a) threefold maximal mixing; and (b) attempts to fit all sources of evidence for oscillations (solar, atmospheric, and accelerator) with three neutrinos. By using mainly Super-Kamiokande data, we show that the case (a) is disfavored, and that the case (b) is definitely ruled out., Comment: 14 pages, 5 figures

The atmospheric neutrino data collected by the Super-Kamiokande experiment span about four decades in neutrino energy E, and are thus appropriate to probe the energy dependence of the oscillation wavelength \lambda associated to nu_mu<--->nu_tau flavor transitions, when these are assumed to explain the data. Such dependence takes the form \lambda^{-1}\propto E^n in a wide class of theoretical models, including ``standard'' oscillations due to neutrino mass and mixing (n=-1), energy-independent oscillations (n=0), and violations of the equivalence principle or of Lorentz invariance (n=1). We study first how the theoretical zenith distributions of sub-GeV, multi-GeV, and upward-going muon events change for different integer values of n. Then we perform a detailed analysis of the Super-Kamiokande data by treating the energy exponent n as a free parameter, with unconstrained scale factors for both the amplitude and the phase of nu_mu<--->nu_tau oscillations. We find a best-fit range n=-0.9 \pm 0.4 at 90% C.L., which confirms the standard scenario (n=-1) as the dominant oscillation mechanism, and strongly constrains possible concurrent exotic processes (n \neq -1). In particular, we work out the interesting case of leading standard oscillations plus subleading terms induced by violations of special or general relativity principles, and obtain extremely stringent upper bounds on the amplitude of such violations in the (nu_mu,nu_tau) sector., Comment: 13 pages (RevTeX) + 6 figures (PostScript, color). Requires epsfig.sty

We calculate the event rates induced by high-intensity radioactive sources of nu_e (51Cr) and of anti-nu_e (90Sr), to be located near the BOREXINO detector. Calculations are performed both in the standard case and assuming non-standard properties of neutrinos, including flavor oscillations, neutrino electromagnetic interactions, and deviations from the standard vector and axial couplings in the nu_e-e interaction. It is shown that, in some cases, the current limits on non-standard neutrino properties can be significantly improved., Comment: 15 pages (RevTeX) + 4 figures (postscript) included with epsfig.sty. Minor changes and corrections, 3 references added. Final version to be published in Europ. Phys. Jour. C

The evidence for $\nu_\mu$ disappearance in the Super-Kamiokande atmospheric neutrino experiment and the negative searches for $\nu_e$ disappearance in the CHOOZ reactor experiment can be easily reconciled by assuming oscillations with large amplitude in the $\nu_\mu\leftrightarrow\nu_\tau$ channel and small (or null) amplitude in the $\nu_\mu\leftrightarrow\nu_e$ channel. It has been claimed, however, that some oscillation scenarios with large $\nu_\mu\leftrightarrow\nu_e$ mixing can also be constructed in agreement with the present data. We investigate quantitatively two such scenarios: (a) threefold maximal mixing; and (b) attempts to fit all sources of evidence for oscillations (solar, atmospheric, and accelerator) with three neutrinos. By using mainly Super-Kamiokande data, we show that the case (a) is disfavored, and that the case (b) is definitely ruled out., Comment: 14 pages, 5 figures

The recent observations of atmospheric nu events from the Super-Kamiokande experiment are compatible with three-flavor neutrino oscillations, occurring dominantly in the nu_mu<--->nu_tau channel and subdominantly in the nu_mu<--->nu_e channel. We present an updated analysis of the three-flavor mass-mixing parameters consistent with the present phenomenology, including the latest 45 kTy data sample from Super-Kamiokande. A comparison with our previous results, based on 33 kTy data, shows that the oscillation evidence is strengthened, and that the neutrino mass-mixing parameters are constrained in smaller ranges., Comment: 5 pages, 3 figures. Presented at WIN99. Updated analysis including 45 kTy Super-Kamiokande data

Neutrino decay has been proposed as a possible solution to the atmospheric neutrino anomaly, in the light of the recent data from the Super-Kamiokande experiment. We investigate this hypothesis by means of a quantitative analysis of the zenith angle distributions of neutrino events in Super-Kamiokande, including the latest (45 kTy) data. We find that the neutrino decay hypothesis fails to reproduce the observed distributions of muons., Comment: 6 pages (RevTeX) + 2 figures (Postscript)

The atmospheric neutrino data collected by the Super-Kamiokande experiment span about four decades in neutrino energy E, and are thus appropriate to probe the energy dependence of the oscillation wavelength \lambda associated to nu_mu<--->nu_tau flavor transitions, when these are assumed to explain the data. Such dependence takes the form \lambda^{-1}\propto E^n in a wide class of theoretical models, including ``standard'' oscillations due to neutrino mass and mixing (n=-1), energy-independent oscillations (n=0), and violations of the equivalence principle or of Lorentz invariance (n=1). We study first how the theoretical zenith distributions of sub-GeV, multi-GeV, and upward-going muon events change for different integer values of n. Then we perform a detailed analysis of the Super-Kamiokande data by treating the energy exponent n as a free parameter, with unconstrained scale factors for both the amplitude and the phase of nu_mu<--->nu_tau oscillations. We find a best-fit range n=-0.9 \pm 0.4 at 90% C.L., which confirms the standard scenario (n=-1) as the dominant oscillation mechanism, and strongly constrains possible concurrent exotic processes (n \neq -1). In particular, we work out the interesting case of leading standard oscillations plus subleading terms induced by violations of special or general relativity principles, and obtain extremely stringent upper bounds on the amplitude of such violations in the (nu_mu,nu_tau) sector., Comment: 13 pages (RevTeX) + 6 figures (PostScript, color). Requires epsfig.sty

We calculate the event rates induced by high-intensity radioactive sources of nu_e (51Cr) and of anti-nu_e (90Sr), to be located near the BOREXINO detector. Calculations are performed both in the standard case and assuming non-standard properties of neutrinos, including flavor oscillations, neutrino electromagnetic interactions, and deviations from the standard vector and axial couplings in the nu_e-e interaction. It is shown that, in some cases, the current limits on non-standard neutrino properties can be significantly improved., Comment: 15 pages (RevTeX) + 4 figures (postscript) included with epsfig.sty. Minor changes and corrections, 3 references added. Final version to be published in Europ. Phys. Jour. C

We present a detailed analysis of the zenith angle distributions of atmospheric neutrino events observed in the Super-Kamiokande (SK) underground experiment, assuming two-flavor and three-flavor oscillations (with one dominant mass scale) among active neutrinos. In particular, we calculate the five angular distributions associated to sub-GeV and multi-GeV \mu-like and e-like events and to upward through-going muons, for a total of 30 accurately computed observables (zenith bins). First we study how such observables vary with the oscillation parameters, and then we perform a fit to the experimental data as measured in SK for an exposure of 33 kTy (535 days). In the two-flavor mixing case, we confirm the results of the SK Collaboration analysis, namely, that \nu_\mu<--->\nu_\tau oscillations are preferred over \nu_\mu<--->\nu_e, and that the no oscillation case is excluded with high confidence. In the three-flavor mixing case, we perform our analysis with and without the additional constraints imposed by the CHOOZ reactor experiment. In both cases, the analysis favors a dominance of the \nu_\mu<--->\nu_\tau channel. Without the CHOOZ constraints, the amplitudes of the subdominant \nu_\mu<--->nu_e and \nu_e<--->\nu_\tau transitions can also be relatively large, indicating that, at present, current SK data do not exclude sizable \nu_e mixing by themselves. After combining the CHOOZ and SK data, the amplitudes of the subdominant transitions are constrained to be smaller, but they can still play a nonnegligible role both in atmospheric and other neutrino oscillation searches. In particular, we find that the \nu_e appearance probability expected in long baseline experiments can reach the testable level of ~15%., Comment: 35 pages (RevTeX), including 20 ps figures (with epsfig.sty)

We present a detailed analysis of the zenith angle distributions of atmospheric neutrino events observed in the Super-Kamiokande (SK) underground experiment, assuming two-flavor and three-flavor oscillations (with one dominant mass scale) among active neutrinos. In particular, we calculate the five angular distributions associated to sub-GeV and multi-GeV \mu-like and e-like events and to upward through-going muons, for a total of 30 accurately computed observables (zenith bins). First we study how such observables vary with the oscillation parameters, and then we perform a fit to the experimental data as measured in SK for an exposure of 33 kTy (535 days). In the two-flavor mixing case, we confirm the results of the SK Collaboration analysis, namely, that \nu_\mu<--->\nu_\tau oscillations are preferred over \nu_\mu<--->\nu_e, and that the no oscillation case is excluded with high confidence. In the three-flavor mixing case, we perform our analysis with and without the additional constraints imposed by the CHOOZ reactor experiment. In both cases, the analysis favors a dominance of the \nu_\mu<--->\nu_\tau channel. Without the CHOOZ constraints, the amplitudes of the subdominant \nu_\mu<--->nu_e and \nu_e<--->\nu_\tau transitions can also be relatively large, indicating that, at present, current SK data do not exclude sizable \nu_e mixing by themselves. After combining the CHOOZ and SK data, the amplitudes of the subdominant transitions are constrained to be smaller, but they can still play a nonnegligible role both in atmospheric and other neutrino oscillation searches. In particular, we find that the \nu_e appearance probability expected in long baseline experiments can reach the testable level of ~15%., Comment: 35 pages (RevTeX), including 20 ps figures (with epsfig.sty)

The present possible evidences in favor of neutrino masses and mixings from solar, atmospheric, and accelerator experiments cannot be all reconciled in a three-family framework, unless some data are excluded. We grade all possible three-family scenarios according to their compatibility with the available data. A recently proposed scenario appears to emerge naturally as the most likely solution to all oscillation evidences, with the only exception of the angular dependence of multi-GeV atmospheric data in the Kamiokande experiment. We describe in detail the status and the phenomenological implications of this ``minimum sacrifice'' solution., Comment: 16 pages (RevTeX) + 3 figures (postscript); requires epsfig.sty

We reanalyze the recent data from the Liquid Scintillator Neutrino Detector (LSND) experiment, that might indicate anti-nu_mu<--->anti-nu_e mixing. This indication is not completely excluded by the negative results of established accelerator and reactor neutrino oscillation searches. We quantify the region of compatibility by means of a thorough statistical analysis of all the available data, assuming both two-flavor and three-flavor neutrino oscillations. The implications for various theoretical scenarios and for future oscillation searches are studied. The relaxation of the LSND constraints under different assumptions in the statistical analysis is also investigated., Comment: 17 pages (RevTeX) + 9 figures (Postscript) included with epsfig.sty

The present possible evidences in favor of neutrino masses and mixings from solar, atmospheric, and accelerator experiments cannot be all reconciled in a three-family framework, unless some data are excluded. We grade all possible three-family scenarios according to their compatibility with the available data. A recently proposed scenario appears to emerge naturally as the most likely solution to all oscillation evidences, with the only exception of the angular dependence of multi-GeV atmospheric data in the Kamiokande experiment. We describe in detail the status and the phenomenological implications of this ``minimum sacrifice'' solution., Comment: 16 pages (RevTeX) + 3 figures (postscript); requires epsfig.sty

We reanalyze the recent data from the Liquid Scintillator Neutrino Detector (LSND) experiment, that might indicate anti-nu_mu<--->anti-nu_e mixing. This indication is not completely excluded by the negative results of established accelerator and reactor neutrino oscillation searches. We quantify the region of compatibility by means of a thorough statistical analysis of all the available data, assuming both two-flavor and three-flavor neutrino oscillations. The implications for various theoretical scenarios and for future oscillation searches are studied. The relaxation of the LSND constraints under different assumptions in the statistical analysis is also investigated., Comment: 17 pages (RevTeX) + 9 figures (Postscript) included with epsfig.sty

We investigate the indications of flavor oscillations that come from the anomalous flavor composition of the atmospheric neutrino flux observed in some underground experiments. We study the information coming from the neutrino-induced $\mu$-like and $e$-like events both in the sub-GeV energy range (Kamiokande, IMB, Fr{\'e}jus, and NUSEX experiments) and in the multi-GeV energy range (Kamiokande experiment). First we analyze all the data in the limits of pure $\nu_\mu\leftrightarrow\nu_\tau$ and $\nu_\mu\leftrightarrow\nu_e$ oscillations. We obtain that $\nu_\mu\leftrightarrow\nu_e$ oscillations provide a better fit, in particular to the multi-GeV data. Then we perform a three-flavor analysis in the hypothesis of dominance of one neutrino square mass difference, $m^2$, implying that the neutrino mixing is parametrized by two angles, $(\psi,\,\phi)\in[0,\,\pi/2]$. We explore the space $(m^2,\,\psi,\,\phi)$ exhaustively, and find the regions favored by the oscillation hypothesis. The results are displayed in a form suited to the comparison with other flavor oscillation searches at accelerator, reactor, and solar $\nu$ experiments. In the analysis, we pay particular attention to the earth matter effects, to the correlation of the uncertainties, and to the symmetry properties of the oscillation probability., Comment: 25 pages (RevTeX) + 12 figures, requires epsfig.sty. All the figures are bitmapped. Postscript figures with full resolution are available at ftp://ftp.sns.ias.edu/pub/lisi/atmpaper

We investigate the indications of flavor oscillations that come from the anomalous flavor composition of the atmospheric neutrino flux observed in some underground experiments. We study the information coming from the neutrino-induced $\mu$-like and $e$-like events both in the sub-GeV energy range (Kamiokande, IMB, Fr{\'e}jus, and NUSEX experiments) and in the multi-GeV energy range (Kamiokande experiment). First we analyze all the data in the limits of pure $\nu_\mu\leftrightarrow\nu_\tau$ and $\nu_\mu\leftrightarrow\nu_e$ oscillations. We obtain that $\nu_\mu\leftrightarrow\nu_e$ oscillations provide a better fit, in particular to the multi-GeV data. Then we perform a three-flavor analysis in the hypothesis of dominance of one neutrino square mass difference, $m^2$, implying that the neutrino mixing is parametrized by two angles, $(\psi,\,\phi)\in[0,\,\pi/2]$. We explore the space $(m^2,\,\psi,\,\phi)$ exhaustively, and find the regions favored by the oscillation hypothesis. The results are displayed in a form suited to the comparison with other flavor oscillation searches at accelerator, reactor, and solar $\nu$ experiments. In the analysis, we pay particular attention to the earth matter effects, to the correlation of the uncertainties, and to the symmetry properties of the oscillation probability., Comment: 25 pages (RevTeX) + 12 figures, requires epsfig.sty. All the figures are bitmapped. Postscript figures with full resolution are available at ftp://ftp.sns.ias.edu/pub/lisi/atmpaper

We present a new approach to the analysis of neutrino oscillation experiments, in the one mass-scale limit of the three-generation scheme. In this framework we reanalyze and recombine the most constraining accelerator and reactor data, in order to draw precise bounds in the new parameter space. We consider our graphical representations as particularly suited to show the interplay among the different oscillation channels. Within the same framework, the discovery potential of future short and long baseline experiments is also investigated, in the light of both the recent signal from the LSND experiment and the atmospheric neutrino anomaly., Comment: uuencoded compressed tar file. Figures (13) available by ftp to ftp://eku.sns.ias.edu/pub/lisi/ (192.16.204.30). Submitted to Physical Review D

We present a new approach to the analysis of neutrino oscillation experiments, in the one mass-scale limit of the three-generation scheme. In this framework we reanalyze and recombine the most constraining accelerator and reactor data, in order to draw precise bounds in the new parameter space. We consider our graphical representations as particularly suited to show the interplay among the different oscillation channels. Within the same framework, the discovery potential of future short and long baseline experiments is also investigated, in the light of both the recent signal from the LSND experiment and the atmospheric neutrino anomaly., Comment: uuencoded compressed tar file. Figures (13) available by ftp to ftp://eku.sns.ias.edu/pub/lisi/ (192.16.204.30). Submitted to Physical Review D

[ES] An active Magellanic penguin (Spheniscus magellanicus) colony has been established on Martillo Island, Beagle Channel (54°54´26” S; 67°22´58” W) since 1976. It is located in remnants of eroded drumlins placed in both ending and joined by gravel terraces of glaciofluvial and marine origin. Forest patches occupy the eastern side of the island while most of the island is covered by bushes, tussocks and grasses. This paper presents penguins as bio-erosion agents on glacial and marine landforms. An analysis of multiple criteria surveyed in the field was performed, using Quantum GIS® 3.2.1 with remote sensing images and a digital model terrain of 12 m resolution. The morphometric data and multicriterial evaluation were collected during 2016-2017 austral summer. Soils and sediments of each landform (drumlin, glaciofluvial terrace, raised beach and beach) were sampled for particle size analysis, to determine if there is any relationship between the morphometric parameters of the cave and the sediments. Four bio-erosion classes were defined based on the erosion features observed in the field. “Moderate” was the prevailing erosion class recorded, in the E-NE part of the island. Bio-erosion features are mainly developed on the N facing slope of the east of the island, where a natural gully drains rainfall water, and over the glaciofluvial and marine terrace surfaces. Erosive features such as caves and bridges are mainly developed in silty drumlins. Pedestals are developed on bare soils and tussocks. Trails and cracks were also described as bio-erosion. No erosive features were recorded in the W part of the island. The bio-erosion map is one of the inputs for environmental degradation analysis and population dynamic research which is being done in the Magellanic penguin colony on Martillo Island, Beagle Channel.