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1. An advanced microencapsulated system: a platform for optimized oral delivery of antidiabetic drug-bile acid formulations

Author

Mooranian, A., Negrulj, R., Mathavan, S., Martinez, J., Sciarretta, J., Chen-Tan, N., Mukkur, T., Mikov, M., Lalic-Popovic, M., Stojancevic, M., Golocorbin-Kon, S., Al-Salami, Hani, Mooranian, A., Negrulj, R., Mathavan, S., Martinez, J., Sciarretta, J., Chen-Tan, N., Mukkur, T., Mikov, M., Lalic-Popovic, M., Stojancevic, M., Golocorbin-Kon, S., and Al-Salami, Hani

Abstract

In previous studies, we have shown that a gliclazide-cholic acid derivative (G-CA) mixture resulted in an enhanced ileal permeation of G (ex vivo). When administered orally to diabetic rats, it brought about a significant hypoglycaemic effect. In this study, we aim to create a novel microencapsulated-formulation of G-CA with uniform and coherent structure that can be further tested in our rat model of type 1 diabetes (T1D). We also aim to examine the effect of CA addition to G microcapsules in the morphology, structure and excipients' compatibility of the newly designed microcapsules.

Published
2015

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