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Purpose: The novel coronavirus disease (COVID-19) has revived the debate on the optimal tidal volume during acute respiratory distress syndrome (ARDS). Some experts recommend 6 mL/kg of predicted body weight (PBW) for all patients, while others suggest 7–9 mL/kg PBW for those with compliance >50 mL/cmH2O. We investigated whether a tidal volume ≥ 7 ml/kg PBW may be safe in COVID-19 patients, particularly those with compliance >50 mL/cmH2O. Materials and methods: This secondary analysis of a multicenter study compares the Intensive Care Unit (ICU) mortality among 600 patients ventilated with <7 or ≥ 7 mL/kg PBW. Compliance was categorized as <40, 40–50, or > 50 mL/cmH2O. Results: 346 patients were ventilated with <7 (6.2 ± 0.5) mL/kg PBW and 254 with ≥7 (7.9 ± 0.9) mL/kg PBW. ICU mortality was 33 % and 29 % in the two groups (p = 0.272). At multivariable regression analysis, tidal volume ≥ 7 mL/kg PBW was associated with lower ICU mortality in the overall population (odds ratio: 0.62 [95 %-confidence interval: 0.40–0.95]) and in each compliance category. Conclusions: A tidal volume ≥ 7 (up to 9) mL/kg PBW was associated with lower ICU mortality in these COVID-19 patients, including those with compliance <40 mL/cmH2O. This finding should be interpreted cautiously due to the retrospective study design. Trial registration: ClinicalTrails.gov NCT04388670.

In recent years, intelligent fault diagnosis based on domain adaptation has been used to address domain shifts in cyber–physical systems; however, the need for acquiring target data sufficiently limits their applicability to unseen working conditions. To overcome such limitations, domain generalization techniques have been introduced to enhance the capacity of fault diagnostic models to operate under unseen working conditions. Nevertheless, existing approaches assume access to extensive labeled training data from various source domains, posing challenges in real-world engineering scenarios due to resource constraints. Moreover, the absence of a mechanism for updating diagnostic models over time calls for the exploration of self-adaptive generalized diagnosis models that are capable of autonomous reconfiguration in response to new unseen working conditions. In such a context, this paper proposes a self-adaptive fault diagnosis system that combines several paradigms, namely Monitor-Analyze-Plan-Execute over a shared Knowledge (MAPE-K), Domain Generalization Network Models (DGNMs), and Digital Twins (DT). The MAPE-K loop enables run-time adaptation to dynamic industrial environments without human intervention. To address the scarcity of labeled training data, digital twins are used to generate supplementary data and continuously tune parameters to reflect the dynamics of new unseen working conditions. DGNM incorporates adversarial learning and a domain-based discrepancy metric to enhance feature diversity and generalization. The introduction of multi-domain data augmentation enhances feature diversity and facilitates learning correlations among multiple domains, ultimately improving the generalization of feature representations. The proposed fault diagnosis system has been evaluated on three publicly available rotating machinery datasets to demonstrate its higher performance in cross-work operation and cross-machine tasks compared to other state-of-the-art methods.

In recent years, intelligent fault diagnosis based on domain adaptation has been used to address domain shifts in cyber–physical systems; however, the need for acquiring target data sufficiently limits their applicability to unseen working conditions. To overcome such limitations, domain generalization techniques have been introduced to enhance the capacity of fault diagnostic models to operate under unseen working conditions. Nevertheless, existing approaches assume access to extensive labeled training data from various source domains, posing challenges in real-world engineering scenarios due to resource constraints. Moreover, the absence of a mechanism for updating diagnostic models over time calls for the exploration of self-adaptive generalized diagnosis models that are capable of autonomous reconfiguration in response to new unseen working conditions. In such a context, this paper proposes a self-adaptive fault diagnosis system that combines several paradigms, namely Monitor-Analyze-Plan-Execute over a shared Knowledge (MAPE-K), Domain Generalization Network Models (DGNMs), and Digital Twins (DT). The MAPE-K loop enables run-time adaptation to dynamic industrial environments without human intervention. To address the scarcity of labeled training data, digital twins are used to generate supplementary data and continuously tune parameters to reflect the dynamics of new unseen working conditions. DGNM incorporates adversarial learning and a domain-based discrepancy metric to enhance feature diversity and generalization. The introduction of multi-domain data augmentation enhances feature diversity and facilitates learning correlations among multiple domains, ultimately improving the generalization of feature representations. The proposed fault diagnosis system has been evaluated on three publicly available rotating machinery datasets to demonstrate its higher performance in cross-work operation and cross-machine tasks compared to other state-of-the-art methods.

In recent years, intelligent fault diagnosis based on domain adaptation has been used to address domain shifts in cyber–physical systems; however, the need for acquiring target data sufficiently limits their applicability to unseen working conditions. To overcome such limitations, domain generalization techniques have been introduced to enhance the capacity of fault diagnostic models to operate under unseen working conditions. Nevertheless, existing approaches assume access to extensive labeled training data from various source domains, posing challenges in real-world engineering scenarios due to resource constraints. Moreover, the absence of a mechanism for updating diagnostic models over time calls for the exploration of self-adaptive generalized diagnosis models that are capable of autonomous reconfiguration in response to new unseen working conditions. In such a context, this paper proposes a self-adaptive fault diagnosis system that combines several paradigms, namely Monitor-Analyze-Plan-Execute over a shared Knowledge (MAPE-K), Domain Generalization Network Models (DGNMs), and Digital Twins (DT). The MAPE-K loop enables run-time adaptation to dynamic industrial environments without human intervention. To address the scarcity of labeled training data, digital twins are used to generate supplementary data and continuously tune parameters to reflect the dynamics of new unseen working conditions. DGNM incorporates adversarial learning and a domain-based discrepancy metric to enhance feature diversity and generalization. The introduction of multi-domain data augmentation enhances feature diversity and facilitates learning correlations among multiple domains, ultimately improving the generalization of feature representations. The proposed fault diagnosis system has been evaluated on three publicly available rotating machinery datasets to demonstrate its higher performance in cross-work operation and cross-machine tasks compared to other state-of-the-art methods.

L'Ottava edizione del manuale tiene conto delle novità intervenute a livello europeo nei due anni intercorsi dalla pubblicazione della precedente edizione. Basti pensare, tra le altre, alla centralità che è tornata ad assumere la prospettiva dell’allargamento dell’Unione a nuovi Stati membri, e alle correlate riflessioni sulle necessarie riforme interne alla stessa Unione (riflessioni che, nel caso del Parlamento europeo, si sono tradotte nella elaborazione di un vero e proprio progetto di revisione dei Trattati); all’attribuzione al Tribunale dell’UE di competenze sui rinvii in via pregiudiziale con l’emendamento dello Statuto della Corte di giustizia dell’UE; ai primi casi rilevanti di “astensione costruttiva”; alla sempre più accentuata centralità delle questioni relative ai valori fondanti dell’Unione e innanzitutto dello Stato di diritto, con la prima applicazione del “regolamento sulla condizionalità” nei confronti dell’Ungheria; al rilancio della prospettiva di adesione dell’Unione alla CEDU; ai chiarimenti offerti dalla Corte nel campo delle relazioni esterne dell’UE ad esempio con riguardo agli accordi misti, al potere di firma, al “comune accordo”; al continuo sviluppo della giurisprudenza in ambiti come quello della cittadinanza europea e della tutela dei diritti fondamentali; all'importanza crescente nella prassi del ricorso ad atti atipici, nonché analogamente, nelle relazioni esterne dell'UE, a strumenti internazionali non vincolanti. A questi, e a molti altri sviluppi relativi ai profili istituzionali dell'ordinamento dell'UE, si affiancano ulteriori interventi volti a rendere sempre più completa e chiara la trattazione.

Nella sentenza IFIC Holding c. Commissione il Tribunale UE si è pronunciato per la prima volta, respingendolo, su un ricorso volto a ottenere l'annullamento di alcune decisioni con le quali la Commissione aveva autorizzato una società europea ad applicare misure restrittive nei confronti della ricorrente, in conformità alla normativa statunitense che stabilisce sanzioni contro l'Iran e in deroga al c.d. "regolamento di blocco" europeo. Il presente contributo esamina la sentenza, riflettendo sia sugli aspetti in merito ai quali il Tribunale ha fornito importanti chiarimenti, sia su alcune questioni che, invece, esso ha ritenuto di non dover affrontare.

Innovative Research Infrastructure on applied Superconductivity (IRIS) is a major project to build a research infrastructure in applied superconductivity, recently approved in Italy and led by INFN. As part of this programme, we are currently designing a Green Superconducting Line (GSL), 130 m long and designed to carry 40 kA of current at 25 kV, 1 GW of power, with almost zero dissipation. The article will present the up-to-date conceptual design status for the GSL. The line will eventually be tested in the new facility being prepared by INFN-Salerno and the University of Salerno (Italy).

Background: Sabatolimab is an immunotherapy targeting T-cell immunoglobulin domain and mucin domain-3 (TIM-3), an immuno-myeloid regulator expressed on immune cells and leukaemic stem cells. In this trial, we compared the efficacy and safety of sabatolimab plus hypomethylating agent with placebo plus hypomethylating agents in previously untreated patients with higher-risk myelodysplastic syndromes. Methods: STIMULUS-MDS1 was a multicentre, randomised, double-blind, placebo-controlled, phase 2 study done at 54 investigational sites in 17 countries. Adult patients (aged ≥18 years) with intermediate-risk, high-risk, and very high-risk myelodysplastic syndromes (according to Revised International Prognostic Scoring System criteria) who had not received previous treatment were included. Patients were randomly assigned (1:1) to intravenous sabatolimab (400 mg on day 8 and 22) or placebo plus a hypomethylating agent (intravenous decitabine 20 mg/m2 on day 1–5 or intravenous or subcutaneous azacitidine 75 mg/m2 on day 1–7 or day 1–5 and day 8 and 9) every 28 days until treatment discontinuation. The two primary endpoints were complete response rate and progression-free survival, assessed in the full analysis set, which included all randomly assigned patients. Complete response was analysed, as prespecified, 7 months after the last patient was randomly assigned. All other analyses presented, including progression-free survival, were done at the final data cutoff prespecified via a protocol amendment on Sept 2, 2021. Safety was assessed in in all patients who received at least one dose of study treatment. This study is registered with ClinicalTrials.gov, NCT03946670, and is ongoing. Findings: Between July 29, 2019, and Aug 10, 2020, 127 patients were randomly assigned to sabatolimab plus a hypomethylating agent group (sabatolimab group; n=65) or placebo plus a hypomethylating agent (placebo group; n=62). The median age of participants was 73 years (IQR 69–77), of whom 86 (68%

Background: Direct-acting antiviral agents (DAAs) are highly effective treatment for chronic hepatitis C (CHC) with a significant rate of sustained virologic response (SVR). The achievement of SVR is crucial to prevent additional liver damage and slow down fibrosis progression. The assessment of fibrosis degree can be performed with transient elastography, magnetic resonance elastography or shear-wave elastography (SWE). Liver elastography could function as a predictor for hepatocellular carcinoma (HCC) in CHC patients treated with DAAs. Aim: To explore the predictive value of SWE for HCC development after complete clearance of hepatitis C virus (HCV). Methods: A comprehensive literature search of clinical studies was performed to identify the ability of SWE to predict HCC occurrence after HCV clearance. In accordance with the study protocol, a qualitative and quantitative analysis of the evidence was planned. Results: At baseline and after 12 wk of follow-up, a trend was shown towards greater liver stiffness (LS) in those who go on to develop HCC compared to those who do not [baseline LS standardized mean difference (SMD): 1.15, 95% confidence interval (95%CI): 020-2.50; LS SMD after 12 wk: 0.83, 95%CI: 0.33-1.98]. The absence of a statistically significant difference between the mean LS in those who developed HCC or not may be related to the inability to correct for confounding factors and the absence of raw source data. There was a statistically significant LS SMD at 24 wk of follow-up between patients who developed HCC vs not (0.64; 95%CI: 0.04-1.24). Conclusion: SWE could be a promising tool for prediction of HCC occurrence in patients treated with DAAs. Further studies with larger cohorts and standardized timing of elastographic evaluation are needed to confirm these data.

isbn: 9788546223633, Pages: 53-65

Este proyecto analiza el diseño de una línea de alta tensión en corriente alterna que une las subestaciones de Magraners y Juneda. Con una tensión de 220 kV y una potencia aparente 860 MVA. El objetivo es evaluar los aspectos eléctricos y mecánicos de la línea, y el impacto del campo electromagnético (CEM) que genera la línea sobre las personas que puedan frecuentar la zona. Utilizamos herramientas de cálculo para obtener las pérdidas que se producen en la línea. Para los cálculos mecánicos se tienen en cuenta los esfuerzos que tienen que soportar los apoyos, aisladores, cimentaciones, conductores y distancias mínimas de seguridad para cumplir con la normativa actual. También analizando los valores del CEM sobre las personas a diferentes distancias de la torre, para cumplir con la normativa vigente. Por otro lado se ha efectuado un estudio sobre el análisis del ciclo de vida (ACV) que puede llegar a tener una línea eléctrica de alta tensión de estas dimensiones, construida en Cataluña. También se han utilizado herramientas con gestión de bases de datos para la ejecución de los planos de situación, con el objetivo de poder observar en condiciones el trazado que efectúa la línea. Por último se ha realizado un presupuesto que tiene en cuenta todo lo mencionado con anterioridad., This project analyzes the design of a high-voltage alternating current line that connects the Magraners and Juneda substations. With a voltage of 220 kV and an apparent power of 860 MVA. The objective is to evaluate the electrical and mechanical aspects of the line and the impact of the electromagnetic field (EMF) generated by the line on people who may frequent the area. Calculation tools are used to obtain the losses that occur in the line. For mechanical calculations, the stresses that the supports, insulators, foundations, conductors, and minimum safety distances must withstand are taken into account to comply with current regulations. The EMF values are also analyzed for people at different distances from the tower to act in accordance with the current regulations. In addition, a study on the life cycle assessment (LCA) that a high-voltage line of these dimensions built in Catalonia may have carried out. Database management tools have also been used for the execution of location layouts, in order to accurately observe the route of the line. Finally, a budget has been prepared that takes into account everything mentioned before.

Uvod: fibrilacija atrija (FA) predstavlja najčešći poremećaj srčanoga ritma u općoj populaciji. Njezina pojavnost raste sa životnom dobi. Ranije smo na raspolaganju za liječenje fibrilacije atrija imali samo antiaritmijske lijekove, no unazad 30 godina u kliničku praksu je uvedena nova metoda liječenja fibrilacije, izolacijom plućnih vena. Bolesnici i metode: retrospektivno istraživanje provedeno je na bolesnicima liječenima od fibrilacije atrija na Odjelu kardiologije Opće bolnice Zadar od 01. siječnja 2018. do 31. prosinca 2022. godine. Tijekom navedenoga razdoblja liječeno je 746 bolesnika, 523 muškarca i 223 žene. Većina bolesnika bila je u dobnoj skupini od 50-70 godina. Istraživanje je provedeno na temelju podataka pohranjenih u bolničkom informatičkom sustavu (BIS). Rezultati: u razdoblju od 01. siječnja 2018. do 31. prosinca 2022. godine u Općoj bolnici Zadar liječeno je 746 bolesnika zbog FA, metodom izolacije plućnih vena. Promatrano prema godinama, 2018. godine učinjeno je 156 izolacija plućnih vena, 2019. godine učinjeno je 127, a 2020. godine 128 zahvata, dok se u 2021. godini bilježi povećenje broja zahvata na 143. Najveće povećanje broja zahvata zabilježeno je 2022. godine, tijekom koje je učinjen 191 zahvat izolacija plućnih vena. Od ukupno 746 izolacija plućnih vena, 523 (70%) je provedeno u muškaraca, a 223 (30%) u žena. Izolaciji plućnih vena su najčešće bili podvrgnuti bolesnici u dobi od 50-70 godina. Najčešća metoda izolacije plućnih vena bila je radiofrekventna ablacija. Zahvatu su nešto češće bili podvrgnuti bolesnici s perzistentnom (52%) u odnosu na paroksizmalnu (48%) fibrilaciju. Zaključak: elektrofiziološki tim Opće bolnice Zadar u liječenju bolesnika s fibrilacijom atrija, uz konzervativne metode liječenja, koristi i invazivnu metodu izolacije plućnih vena. Metoda se najčešće koristi kod bolesnika s perzistentnom atrijskom fibrilacijom i to prvenstveno kod bolesnika mlađe životne dobi.

We introduce the WELLBY, a new measure of social value and progress, which can contribute to the assessment of progress towards the wellbeing of the economy and steer towards activities with the most wellbeing per financial resources invested. After providing a short rationale for the WELLBY, we give a definition and an overview of its properties. We then show how WELLBYs can help decision-makers with ex-ante policy appraisals and deliver a practical example of a youth traineeship programme. We also discuss how coefficients from ex-post wellbeing policy evaluations are now being collected as part of social value banks around the world, feeding into future appraisals. Finally, we illustrate how WELLBYs can be used to measure social progress overall, going beyond GDP.

Background/Objectives: This cross-national study focuses on adolescents who provide care and support to family members or significant others. Current evidence regarding their mental health and solutions to strengthen it is limited and mostly available in a few countries. The aim of this study is to evaluate the results of a primary prevention intervention for improving the mental health and well-being of adolescent young carers (AYCs) aged 15–17 years in six European countries. The intervention was based on a psychoeducational program and tools adapted from the Discoverer, Noticer, Advisor, and Values (DNA-V) model. Methods: We designed a randomized controlled trial with 217 AYCs participating in the study, either in the intervention or control group. Quantitative and qualitative data were collected via questionnaires at baseline, post-intervention, and a 3-month follow up. Results: The results were mixed, as positive improvements in primary (i.e., psychological well-being and skills) and secondary (school/training/work functioning) outcomes were shown by the experimental group but, in most cases, they were not statistically significant. The qualitative data supported positive claims about the intervention and its appropriateness for AYCs. Conclusions: The study implementation during the peak of the COVID-19 pandemic forced the consortium to adapt the design and may have influenced the results. More long-term studies are needed to assess similar mental health programs with this hard-to-reach target group.

Introduction: Citrus is an important fruit crop for human health. The sensitivity of citrus trees to a wide range of abiotic stresses is a major challenge for their overall growth and productivity. Among these abiotic stresses, salinity results in a significant loss of global citrus yield. In order to find straightforward and sustainable solutions for the future and to ensure citrus productivity, it is of paramount importance to decipher the mechanisms responsible for salinity stress tolerance. Thisstudy aimed to investigate how ploidy levels influence salt stress tolerance in citrus by comparing the transcriptomic responses of diploid and tetraploid genotypes. In a previous article we investigated the physiological and biochemical response of four genotypes with different ploidy levels: diploid trifoliate orange (Poncirus trifoliata [L.] Raf.) (PO2x) and Cleopatra mandarin (Citrus reshni Hort. Ex Tan.) (CL2x) and their respective tetraploids (PO4x, CL4x). Methods: In this study, we useda multifactorial gene selection and gene clustering approach to finely dissect the influence of ploidy level on the salt stress response of each genotype. Following transcriptome sequencing, differentially expressed genes (DEGs) were identified in response to salt stress in leaves and roots of the different citrus genotypes. Result and discussion: Gene expression profiles and functional characterization of genes involved in the response to salt stress, as a function of ploidy level and the interaction between stress response and ploidy level, have enabled us to highlight the mechanisms involved in the varieties tested. Saltstress induced overexpression of carbohydrate biosynthesis and cell wall remodelling- related genes specifically in CL4x Ploidy level enhanced oxidative stress response in PO and ion management capacity in both genotypes. Results further highlighted that under stress conditions, only the CL4x genotype up- regulated genes involved in sugar biosynthesis, transport ma

Extreme-Mass-Ratio Inspirals (EMRIs) are one of the key targets for future space-based gravitational wave detectors, such as LISA. The scientific potential of these sources can only be fully realized with fast and accurate waveform models. In this work, we extend the \textsc{FastEMRIWaveform} (\texttt{FEW}) framework by providing fully relativistic waveforms at adiabatic order for circular, equatorial orbits in Kerr spacetime, for mass ratios up to $10^{-3}$. We study the importance of including relativistic corrections in the waveform for both vacuum and non-vacuum environments. For EMRIs in vacuum, we find that non-relativistic waveforms can result in $\sim 35\%$ error in the predicted source's horizon redshift. By developing relativistic non-vacuum EMRI waveforms, we demonstrate significant improvements in detecting environmental effects. Our analysis shows that incorporating relativistic corrections enhances constraints on accretion disks, modeled through power-law torques, and improves the constraints on disk parameters (error $\sim6\%$), representing a significant improvement from previous estimates. We also estimated the evidence for models in a scenario where ignoring the accretion disk causes bias in parameter estimation (PE) and report a $\log_{10}$ Bayes factor of $1.1$ in favor of the accretion disk model. Additionally, in a fully relativistic setup, we estimate the parameters of superradiant scalar clouds with high accuracy, achieving errors below $5\%$ for the scalar cloud's mass and below $0.5\%$ for the ultralight field's mass. These results demonstrate that incorporating relativistic effects greatly enhances the accuracy and reliability of waveform predictions, essential for PE and model selection., Comment: 22 pages, 13 figures

We introduce the WELLBY, a new measure of social value and progress, which can contribute to the assessment of progress towards the wellbeing of the economy and steer towards activities with the most wellbeing per financial resources invested. After providing a short rationale for the WELLBY, we give a definition and an overview of its properties. We then show how WELLBYs can help decision-makers with ex-ante policy appraisals and deliver a practical example of a youth traineeship programme. We also discuss how coefficients from ex-post wellbeing policy evaluations are now being collected as part of social value banks around the world, feeding into future appraisals. Finally, we illustrate how WELLBYs can be used to measure social progress overall, going beyond GDP.

Inquiries into properties of brain structure and function have progressed due to developments in magnetic resonance imaging (MRI). To sustain progress in investigating and quantifying neuroanatomical details in vivo, the reliability and validity of brain measurements are paramount. Quality control (QC) is a set of procedures for mitigating errors and ensuring the validity and reliability of brain measurements. Despite its importance, there is little guidance on best QC practices and reporting procedures. The study of hippocampal subfields in vivo is a critical case for QC because of their small size, inter-dependent boundary definitions, and common artifacts in the MRI data used for subfield measurements. We addressed this gap by surveying the broader scientific community studying hippocampal subfields on their views and approaches to QC. We received responses from 37 investigators spanning 10 countries, covering different career stages, and studying both healthy and pathological development and aging. In this sample, 81% of researchers considered QC to be very important or important, and 19% viewed it as fairly important. Despite this, only 46% of researchers reported on their QC processes in prior publications. In many instances, lack of reporting appeared due to ambiguous guidance on relevant details and guidance for reporting, rather than absence of QC. Here, we provide recommendations for correcting errors to maximize reliability and minimize bias. We also summarize threats to segmentation accuracy, review common QC methods, and make recommendations for best practices and reporting in publications. Implementing the recommended QC practices will collectively improve inferences to the larger population, as well as have implications for clinical practice and public health.

Background Immune checkpoint inhibitors have changed previous treatment paradigm of advanced urothelial carcinoma (UC). The ARON-2 study (NCT05290038) aimed to assess the real-world effectiveness of pembrolizumab in patients recurred or progressed after platinum-based chemotherapy. Patients and Methods Medical records of patients with documented metastatic UC treated by pembrolizumab as second-line therapy were retrospectively collected from 88 institutions in 23 countries. Patients were assessed for overall survival (OS), progression-free survival (PFS) and overall response rate (ORR). Cox proportional hazards models were adopted to explore the presence of prognostic factors. Results In total, 836 patients were included: 544 patients (65%) received pembrolizumab after progression to first-line platinum-based chemotherapy in the metastatic setting (cohort A) and 292 (35%) after recurring within < 12 months since the completion of adjuvant or neoadjuvant chemotherapy (cohort B). The median follow-up time was 15.3 months. The median OS and the ORR were 10.5 months and 31% in the overall study population, 9.1 months and 29% in cohort A and 14.6 months and 37% in cohort B. At multivariate analysis, ECOG-PS >= 2, bone metastases, liver metastases and pembrolizumab setting (cohort A vs B) proved to be significantly associated with worst OS and PFS. Stratified by the presence of 0, 1-2 or 3-4 prognostic factors, the median OS was 29.4, 12.5 and 4.1 months (p < 0.001), while the median PFS was 12.2, 6.4 and 2.8 months, respectively (p < 0.001). Conclusions Our study confirms that pembrolizumab is effective in the advanced UC real-world context, showing outcome differences between patients recurred or progressed after platinum-based chemotherapy.

Abstract: For every patient, the MR safety evaluation should include the assessment of risks in three key areas, each corresponding to a specific hazard posed by the electromagnetic fields generated by the MR scanner: ferromagnetic attraction and displacement by the static field; stimulation, acoustic noise, and device interaction by the gradient fields; and bulk and focal heating by the radiofrequency field. MR safety guidelines and procedures are typically designed around the “average” patient: adult, responsive, and of typical habitus. For this type of patient, we can safely expect that a detailed history can identify metallic objects inside and outside the body, verbal contact during the scan can detect signs of discomfort from heating or acoustic noise, and safety calculations performed by the scanner can prevent hyperthermia. However, for some less common patient categories, these assumptions do not hold. For instance, patients with larger habitus, febrile patients, or pregnant people are more subject to bulk heating and require more conservative MR protocols, while at the same time presenting challenges during positioning and preparation. Other vulnerable categories are infants, children, and patients unable to communicate, who might require screening for ferromagnetic objects with other imaging modalities or dedicated equipment. This paper will provide guidance to implement appropriate safety margins in the workflow and scanning protocols in various vulnerable patient categories that are sometimes overlooked in basic MR safety guidance documents. Clinical relevance statement: Special care in the implementation of MR safety procedures is of paramount importance in the handling of patients. While most institutions have streamlined operations in place, some vulnerable patient categories require specific considerations to obtain images of optimal quality while minimizing the risks derived by exposure to the MR environment. Key Points: Patients unable to effec

This research presents results on the meaning of school education from the perspective of the actors of the educational and social environment, namely, the teachers. The objective is to account for the challenges of the family-school relationship in an indigenous context, from the perspective of the teachers of two rural schools located in Mapuche communities of La Araucanía, a Southern region in Chile. The research problem states that the family-school relationship in a Mapuche context has historically been characterized by power relations that deny the involvement of the family members in the processes of intercultural school management. In this way, just nominal participation in administrative aspects is assumed. The methodology is qualitative with a descriptive scope, and the participants are six teachers. The data collection instrument is the semi-structured interview, and the data analysis technique is based on content analysis in complementarity with grounded theory. The main results show hegemonical powers that persist in the family-school relationship in the Mapuche context, marked by racism and discrimination. The main conclusions highlight the urgency of establishing continuous training on interculturality for schoolteachers working in Mapuche communities, which might allow reversing the hegemonical practices towards ‘the Mapuche’ present in the school. In this context, teacher training on interculturality would allow strengthening the educational relationship between the indigenous family and the school based on the incorporation of indigenous educational knowledge and skills, contributing to a school education with an intercultural perspective., El artículo expone resultados de investigación sobre el sentido de la educación escolar desde la perspectiva de los actores del medio educativo y social. El objetivo es dar cuenta de los desafíos de la relación familia-escuela en contexto indígena, desde la perspectiva de los profesores de dos escuelas rurales situadas en comunidades mapuches de La Araucanía, Chile. El problema de investigación plantea que en la educación escolar en contexto mapuche la vinculación familia-escuela, históricamente, se ha caracterizado por relaciones de poder, que niegan la participación de la familia en los procesos de gestión escolar intercultural. De esta manera, se asume una participación funcionalista articulada a aspectos administrativos. La metodología es cualitativa con un nivel de alcance descriptivo, los participantes son seis profesores. El instrumento de recolección de información es la entrevista semidirigida, la técnica de análisis de la información es el análisis de contenido en complementariedad con la teoría fundamentada. Los principales resultados dan cuenta de relaciones de poder que persisten en la relación familia-escuela en contexto mapuche sustentados en una relación de racismo y discriminación. Las principales conclusiones relevan la urgencia de establecer una formación continua sobre interculturalidad para los actores del medio educativo, lo que permitiría revertir las prácticas discriminatorias hacia “lo mapuche” presentes en la escuela. Esto, en contexto mapuche permitiría fortalecer las relaciones educativas entre familia indígena y escuela con base en la incorporación de los saberes y conocimientos educativos indígenas, contribuyendo en una educación escolar en perspectiva intercultural.

Predicting how plants respond to drought requires an understanding of how physiological mechanisms and drought response strategies occur, as these strategies underlie rates of gas exchange and productivity. We assessed the response of 11 plant traits to repeated experimental droughts in four co-occurring species of central Australia. The main goals of this study were to: (i) compare the response to drought between species; (ii) evaluate whether plants acclimated to repeated drought; and (iii) examine the degree of recovery in leaf gas exchange after cessation of drought. Our four species of study were two tree species and two shrub species, which field studies have shown to occupy different ecohydrological niches. The two tree species (Eucalyptus camaldulensis Dehnh. and Corymbia opaca (D.J.Carr & S.G.M.Carr) K.D.Hill & L.A.S.Johnson) had large reductions in stomatal conductance (gs) values, declining by 90% in the second drought. By contrast, the shrub species (Acacia aptaneura Maslin & J.E.Reid and Hakea macrocarpa A.Cunn. ex R.Br.) had smaller reductions gs in the second drought of 52 and 65%, respectively. Only A. aptaneura showed a physiological acclimatation to drought due to small declines in gs versus ᴪpd (0.08 slope) during repeated droughts, meaning they maintained higher rates of gs compared with plants that only experienced one final drought (0.19 slope). All species in all treatments rapidly recovered leaf gas exchange and leaf mass per area following drought, displaying physiological plasticity to drought exposure. This research refines our understanding of plant physiological responses to recurrent water stress, which has implications for modelling of vegetation, carbon assimilation and water use in semi-arid environments under drought.

Predicting how plants respond to drought requires an understanding of how physiological mechanisms and drought response strategies occur, as these strategies underlie rates of gas exchange and productivity. We assessed the response of 11 plant traits to repeated experimental droughts in four co-occurring species of central Australia. The main goals of this study were to: (i) compare the response to drought between species; (ii) evaluate whether plants acclimated to repeated drought; and (iii) examine the degree of recovery in leaf gas exchange after cessation of drought. Our four species of study were two tree species and two shrub species, which field studies have shown to occupy different ecohydrological niches. The two tree species (Eucalyptus camaldulensis Dehnh. and Corymbia opaca (D.J.Carr & S.G.M.Carr) K.D.Hill & L.A.S.Johnson) had large reductions in stomatal conductance (gs) values, declining by 90% in the second drought. By contrast, the shrub species (Acacia aptaneura Maslin & J.E.Reid and Hakea macrocarpa A.Cunn. ex R.Br.) had smaller reductions gs in the second drought of 52 and 65%, respectively. Only A. aptaneura showed a physiological acclimatation to drought due to small declines in gs versus ᴪpd (0.08 slope) during repeated droughts, meaning they maintained higher rates of gs compared with plants that only experienced one final drought (0.19 slope). All species in all treatments rapidly recovered leaf gas exchange and leaf mass per area following drought, displaying physiological plasticity to drought exposure. This research refines our understanding of plant physiological responses to recurrent water stress, which has implications for modelling of vegetation, carbon assimilation and water use in semi-arid environments under drought.

A child's disability, long-term illness, or mental ill-health is known to affect siblings' health, social life, school engagement, and quality of life. This article addresses a research gap by its focus on young sibling carers and the impact of providing care to a sibling. A cross-national survey study was conducted in 2018-2019 (Italy, the Netherlands, Slovenia, Sweden, Switzerland, the UK) to examine the incidence of adolescent sibling carers, the extent of care they provide, and their self-reported health, well-being, and school situation. The survey was completed by 7146 adolescents, aged 15-17, and 1444 of them provided care to family members with health-related conditions. Out of these, 286 were identified as Sibling Carers and 668 as Parent Carers, while 181 had both sibling(s) and parent(s) with health-related conditions, and thus were identified as Sibling-Parent Carers. Sibling Carers and Sibling-Parent Carers carried out higher levels of caring activities compared to Parent Carers. They reported both positive aspects of caring, such as increased maturity, and negative aspects, such as mental ill-health, impact on schooling and a lack of support. To reduce the negative aspects of a sibling carer role, it is important to recognise them and to implement early preventive measures and formal support.

A child's disability, long-term illness, or mental ill-health is known to affect siblings' health, social life, school engagement, and quality of life. This article addresses a research gap by its focus on young sibling carers and the impact of providing care to a sibling. A cross-national survey study was conducted in 2018-2019 (Italy, the Netherlands, Slovenia, Sweden, Switzerland, the UK) to examine the incidence of adolescent sibling carers, the extent of care they provide, and their self-reported health, well-being, and school situation. The survey was completed by 7146 adolescents, aged 15-17, and 1444 of them provided care to family members with health-related conditions. Out of these, 286 were identified as Sibling Carers and 668 as Parent Carers, while 181 had both sibling(s) and parent(s) with health-related conditions, and thus were identified as Sibling-Parent Carers. Sibling Carers and Sibling-Parent Carers carried out higher levels of caring activities compared to Parent Carers. They reported both positive aspects of caring, such as increased maturity, and negative aspects, such as mental ill-health, impact on schooling and a lack of support. To reduce the negative aspects of a sibling carer role, it is important to recognise them and to implement early preventive measures and formal support.

A child's disability, long-term illness, or mental ill-health is known to affect siblings' health, social life, school engagement, and quality of life. This article addresses a research gap by its focus on young sibling carers and the impact of providing care to a sibling. A cross-national survey study was conducted in 2018-2019 (Italy, the Netherlands, Slovenia, Sweden, Switzerland, the UK) to examine the incidence of adolescent sibling carers, the extent of care they provide, and their self-reported health, well-being, and school situation. The survey was completed by 7146 adolescents, aged 15-17, and 1444 of them provided care to family members with health-related conditions. Out of these, 286 were identified as Sibling Carers and 668 as Parent Carers, while 181 had both sibling(s) and parent(s) with health-related conditions, and thus were identified as Sibling-Parent Carers. Sibling Carers and Sibling-Parent Carers carried out higher levels of caring activities compared to Parent Carers. They reported both positive aspects of caring, such as increased maturity, and negative aspects, such as mental ill-health, impact on schooling and a lack of support. To reduce the negative aspects of a sibling carer role, it is important to recognise them and to implement early preventive measures and formal support.

isbn: 9788546223633, Volume: 1, Pages: 53-65

During the COVID-19 outbreak, the care services interruption/delay resulted in increased amount of care for informal caregivers of older people with long-term care needs. This study aimed at understanding how the Pandemic affected physical health, mental well-being and quality of life of older people' informal caregivers of different ages and to what extent starting caregiving affected such life realms among new caregivers. An online survey was carried out in Winter 2020-2021 targeted to informal caregivers living in 16 European countries. A sub-sample of 848 adult (aged 18-64) was compared to another of 542 older (over 65) informal caregivers. People who started caring during the Pandemic were also identified and the impact of the Pandemic on the three life realms of this group were analysed separately by gender and age. The differences between the two groups of adult and older caregivers were estimated using logistic regression, adjusted for potential confounders. Analyses were repeated after propensity score matching. During the second Pandemic wave hitting Europe in Winter 2020-21, regardless of age, being female entailed a worsening in physical health, mental well-being and quality of life, in line with previous research Also new caregivers were mostly females and their physical health and quality of life were worsened by caregiving. Gender-specific work-life balance policies and measures are needed to support female working caregivers. More attention should be paid to older female caregivers through scheduled physical and mental health screenings and home visits. Future studies on the topic in a gender and intergenerational perspective are encouraged.

The IUCN Red List of Threatened Species underpins much decision-making in conservation and plays a key role in monitoring the status and trends of biodiversity. However, the shortage of funds and assessor capacity slows the uptake of novel data and techniques, hampering its currency, applicability, consistency and long-term viability. To help address this, we developed sRedList, a user-friendly online platform that assists Red List assessors through a step-by-step process to estimate key parameters in a standardised and reproducible fashion. Through the platform, assessors can swiftly generate outputs including species' range maps, lists of countries of occurrence, lower and upper bounds of area of occupancy, habitat preferences, trends in area of habitat, and levels of fragmentation. sRedList is compliant with the IUCN Red List guidelines and outputs are interoperable with the Species Information Service (SIS; the IUCN Red List database) in support of global, regional and national assessments and reassessments. sRedList can also help assessors prioritise species for reassessment. sRedList was released in October 2023, with a complete documentation package (including text documentation, ‘cheatsheets’, and 15 video tutorials), and will soon be highlighted in the official Red List online training course. sRedList will help to bridge the gap between extinction risk research and Red List assessment practice, increase the taxonomic coverage and consistency of assessments, and ensure the IUCN Red List is up-to-date to best support conservation policy and practice across the world.

[EN]The project addresses the topic of reclassifying an urban area of the city of Livorno caracterised by the presence of the Forte San Pietro and the Rivellino di San Marco built at the end of the 17th century to complete Livorno’s northern defensive front protecting the residential quarter of La Venezia. In particular, Forte San Pietro, constructed on the orders of Governor Dal Borro according to the designs of the architect, Baldi, surrounded on one side by the sea and on the other by the Fosso Reale, it was the site of the public slaughterhouse (which was in operation until 1996) from 1889 and this saved it from demolition in the following years, ensuring links with the nearby San Marco’s station and free land for the city’s expansion. This transformed the Rivellino, which was the object of a residential development plan in the early 1800s and the location of the city’s sewage treatment plant. The project area is located in the north-west of the municipal region of Livorno and is configured as a passage area, in which the city environment abruptly changes from the industrial port to the urban and where traces of the ancient fortifications are evident (in addition to Forte San Pietro there are the constituent parts of the Lorenesi city walls) and where a system of canals and cellars is testimony to this particular area of the city’s characteristic special relationship with water. The study was initially focused on the analysis (historical, functional and regulatory) of the regional context so that the characteristic elements of the area being studied were clear and this enabled the objectives to be pursued in the masterplan to be identified.

During the COVID-19 outbreak, the care services interruption/delay resulted in increased amount of care for informal caregivers of older people with long-term care needs. This study aimed at understanding how the Pandemic affected physical health, mental well-being and quality of life of older people' informal caregivers of different ages and to what extent starting caregiving affected such life realms among new caregivers. An online survey was carried out in Winter 2020-2021 targeted to informal caregivers living in 16 European countries. A sub-sample of 848 adult (aged 18-64) was compared to another of 542 older (over 65) informal caregivers. People who started caring during the Pandemic were also identified and the impact of the Pandemic on the three life realms of this group were analysed separately by gender and age. The differences between the two groups of adult and older caregivers were estimated using logistic regression, adjusted for potential confounders. Analyses were repeated after propensity score matching. During the second Pandemic wave hitting Europe in Winter 2020-21, regardless of age, being female entailed a worsening in physical health, mental well-being and quality of life, in line with previous research Also new caregivers were mostly females and their physical health and quality of life were worsened by caregiving. Gender-specific work-life balance policies and measures are needed to support female working caregivers. More attention should be paid to older female caregivers through scheduled physical and mental health screenings and home visits. Future studies on the topic in a gender and intergenerational perspective are encouraged.

During the COVID-19 outbreak, the care services interruption/delay resulted in increased amount of care for informal caregivers of older people with long-term care needs. This study aimed at understanding how the Pandemic affected physical health, mental well-being and quality of life of older people' informal caregivers of different ages and to what extent starting caregiving affected such life realms among new caregivers. An online survey was carried out in Winter 2020-2021 targeted to informal caregivers living in 16 European countries. A sub-sample of 848 adult (aged 18-64) was compared to another of 542 older (over 65) informal caregivers. People who started caring during the Pandemic were also identified and the impact of the Pandemic on the three life realms of this group were analysed separately by gender and age. The differences between the two groups of adult and older caregivers were estimated using logistic regression, adjusted for potential confounders. Analyses were repeated after propensity score matching. During the second Pandemic wave hitting Europe in Winter 2020-21, regardless of age, being female entailed a worsening in physical health, mental well-being and quality of life, in line with previous research Also new caregivers were mostly females and their physical health and quality of life were worsened by caregiving. Gender-specific work-life balance policies and measures are needed to support female working caregivers. More attention should be paid to older female caregivers through scheduled physical and mental health screenings and home visits. Future studies on the topic in a gender and intergenerational perspective are encouraged.

During the COVID-19 outbreak, the care services interruption/delay resulted in increased amount of care for informal caregivers of older people with long-term care needs. This study aimed at understanding how the Pandemic affected physical health, mental well-being and quality of life of older people' informal caregivers of different ages and to what extent starting caregiving affected such life realms among new caregivers. An online survey was carried out in Winter 2020-2021 targeted to informal caregivers living in 16 European countries. A sub-sample of 848 adult (aged 18-64) was compared to another of 542 older (over 65) informal caregivers. People who started caring during the Pandemic were also identified and the impact of the Pandemic on the three life realms of this group were analysed separately by gender and age. The differences between the two groups of adult and older caregivers were estimated using logistic regression, adjusted for potential confounders. Analyses were repeated after propensity score matching. During the second Pandemic wave hitting Europe in Winter 2020-21, regardless of age, being female entailed a worsening in physical health, mental well-being and quality of life, in line with previous research Also new caregivers were mostly females and their physical health and quality of life were worsened by caregiving. Gender-specific work-life balance policies and measures are needed to support female working caregivers. More attention should be paid to older female caregivers through scheduled physical and mental health screenings and home visits. Future studies on the topic in a gender and intergenerational perspective are encouraged.

Issue Addressed: There is considerable evidence that public stigma around mental illness inhibits help-seeking for mental health problems. Hence there have been many interventions and campaigns designed to reduce stigma around mental illness. However, as far as could be ascertained, none of these stigma reduction interventions has reported any substantial impact of reducing stigma on people's mental health help-seeking behaviours. The aim of this paper is to report on the impact of the Act-Belong-Commit positive mental health promotion Campaign on help-seeking via increasing perceived openness around mental health and reducing perceived stigma around mental illness. Methods: State-wide computer assisted telephone interviews (CATIs) of the general adult population were undertaken in 2018 and 2019 (N = 600 adults per year). The questionnaire included measures of respondents' awareness of the Act-Belong-Commit Campaign, their beliefs about the Campaign's impact on mental illness stigma and openness around mental health issues, and whether they had sought help for or information about a mental health problem as a result of their exposure to the Campaign. Results: Those who believed the Act-Belong-Commit Campaign increased openness around mental health issues were significantly more likely than those not holding this belief to have sought information about mental health and to have sought help for a mental health problem as a result of their exposure to the Campaign. Those who believed the Act-Belong-Commit Campaign decreased stigma around mental illness versus those not holding this belief were significantly more likely to have sought information, and more likely, but not significantly so, to have sought help as a result of their exposure to the Campaign. Overall, the effect was slightly greater for increased openness. Conclusion: As far as we are aware, these are the first reported findings of a positive impact on mental health help-seeking behaviours as a result of a