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4 results on '"Sachana M"'

1. Towards developing a harmonized experimental protocol of embryonic zebrafish light/dark transition behavior test for Organisation for Economic Co-operation and Development (OECD) Developmental Neurotoxicity (DNT) In-Vitro Testing Battery

Author

Sanz, C.M., Schiavone, V., Ibarra, J., Di Donato, V., Truong, L., Tanguay, R., Hsieh, J.-H., Ryan, K., Ellis, L., Molina Martinez, B., Del Pozo, A., Alzualde, A., Muriana, A., Klüver, Nils, Behl, M., Woodland, C., Sachana, M., Hessel, E., Sanz, C.M., Schiavone, V., Ibarra, J., Di Donato, V., Truong, L., Tanguay, R., Hsieh, J.-H., Ryan, K., Ellis, L., Molina Martinez, B., Del Pozo, A., Alzualde, A., Muriana, A., Klüver, Nils, Behl, M., Woodland, C., Sachana, M., and Hessel, E.

Abstract

no abstract

Published
2023

2. Zebrafish, a novel key player for human risk assessment: latest advances on developmental neurotoxicity from an international consortium

Author

Sanz, C.M., Ibarra, J., Rubbini, D., Hsieh, J.-H., Ellis, L., Alzualde, A., Truong, L., Klüver, Nils, Muriana, A., Ryan, K., Behl, M., Molina, B., Legradi, J., Padilla, S., Woodland, C., Tanguay, R., Hill, B., Shafer, T., Sachana, M., Terriente, J., Di Donato, V., Schiavone, V., Hessel, E., Sanz, C.M., Ibarra, J., Rubbini, D., Hsieh, J.-H., Ellis, L., Alzualde, A., Truong, L., Klüver, Nils, Muriana, A., Ryan, K., Behl, M., Molina, B., Legradi, J., Padilla, S., Woodland, C., Tanguay, R., Hill, B., Shafer, T., Sachana, M., Terriente, J., Di Donato, V., Schiavone, V., and Hessel, E.

Abstract

no abstract

Published
2022

3. An inter-laboratory case study to harmonize zebrafish light-dark transition test to predict developmental neurotoxicity for the OECD guidance document

Author

Alzualde, A., Hsieh, J.-H., Ellis, L., Schiavone, V., Truong, L., Legradi, J., Rubbini, D., Woodland, C., Klüver, Nils, Ryan, K., Behl, M., Terriente, J., Muriana, A., Tanguay, R., Sachana, M., Hill, B., Padilla, S., Shafer, T., Hessel, E., Alzualde, A., Hsieh, J.-H., Ellis, L., Schiavone, V., Truong, L., Legradi, J., Rubbini, D., Woodland, C., Klüver, Nils, Ryan, K., Behl, M., Terriente, J., Muriana, A., Tanguay, R., Sachana, M., Hill, B., Padilla, S., Shafer, T., and Hessel, E.

Abstract

no abstract

Published
2021

4. Finding synergies for 3Rs - Toxicokinetics and read-across: Report from an EPAA partners' Forum

Author

Universitat Rovira i Virgili, Laroche C, Aggarwal M, Bender H, Benndorf P, Birk B, Crozier J, Dal Negro G, De Gaetano F, Desaintes C, Gardner I, Hubesch B, Irizar A, John D, Kumar V, Lostia A, Manou I, Monshouwer M, Müller BP, Paini A, Reid K, Rowan T, Sachana M, Schutte K, Stirling C, Taalman R, van Aerts L, Weissenhorn R, Sauer UG, Universitat Rovira i Virgili, and Laroche C, Aggarwal M, Bender H, Benndorf P, Birk B, Crozier J, Dal Negro G, De Gaetano F, Desaintes C, Gardner I, Hubesch B, Irizar A, John D, Kumar V, Lostia A, Manou I, Monshouwer M, Müller BP, Paini A, Reid K, Rowan T, Sachana M, Schutte K, Stirling C, Taalman R, van Aerts L, Weissenhorn R, Sauer UG

Abstract

The European Partnership for Alternative Approaches to Animal Testing (EPAA) convened a Partners' Forum Toxicokinetics and Read-Across to provide an overview on research activities to develop in vitro toxicokinetics methods and physiologically-based kinetic (PBK) models and to find synergies to enhance use of toxicokinetic data to strengthen read-across. Currently, lacking toxicokinetic data often prevent the application of read-across. Preferably, toxicokinetic data should be generated using in vitro and in silico tools and anchored towards human relevance. In certain sectors, PBK modelling is being used for risk assessment, but less so in others. Specific activities were identified to facilitate the use of in vitro and in silico toxicokinetic data to support read-across: The collation of available tools indicating the parameters and applicability domains covered; endpoint-specific guidance on toxicokinetics parameters required for read-across; case studies exemplifying how toxicokinetic data help support read-across. Activities to enhance the scientific robustness of read-across include the further user-friendly combination of read-across tools and formal guidance by the authorities specifying the minimum information requirements to justify read-across for a given toxicity endpoint. The EPAA was invited to continue dissemination activities and to explore possibilities to collate a contemporaneous list of open toxicokinetics tools that assist risk assessment.

Published
2018

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