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Anca Diana Maierean,1,* Ioana Roxana Bordea,2,* Tudor Salagean,3 Reem Hanna,4,5 Teodora Gabriela Alexescu,6 Ana Chis,1 Doina Adina Todea1,* 1Department of Pneumology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania; 2Department of Oral Rehabilitation, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania; 3Department of Land Measurements and Exact Sciences, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania; 4Department of Surgical Sciences and Integrated Diagnostics, Laser Therapy Centre, University of Genoa, Genoa, 16132, Italy; 5Department of Oral Surgery, Dental Institute, King’s College Hospital NHS Foundation Trust, London, SE5 9RS, UK; 6Department of Internal Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania*These authors contributed equally to this workCorrespondence: Tudor Salagean Email tudor.salagean@usamvcluj.roandIoana Roxana Bordea Cluj-Napoca County, Gheorghe Lazar Street, No. 4, Building D4, Ap 4, Tel +40744919391Email roxana.bordea@ymail.comBackground: Obstructive sleep apnea (OSA) is a highly prevalent disease with substantial public health burden. In most of the cases, there is a genetic predisposition to OSA. Serotonin/T-HydroxyTriptamine (5-HT) plays a key role in ventilatory stimulation, while the polymorphism of the serotonin transporter gene (STG) leads to alterations in serotonin level, making it important in OSA.Objective: To examine whether the 5-HydroxyTriptamine and the genetic predisposition influence the incidence and evolution of OSA, we reviewed randomized, controlled trials and observational studies on the selected topic. The secondary objective was to determine the metabolic effects of the circulating serotonin in other tissues (liver, pancreas, gut, brown adipose tissue, and white adipose tissue) and its role in the development of obesity.Data Sou