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1. The CHASIT study:sequential chemo-immunotherapy in patients with locally advanced urothelial cancer – a non-randomized phase II clinical trial

Author

Rutten, V. C., Salhi, Y., Robbrecht, G. J., de Wit, R., van Leenders, G. J.L.H., Zuiverloon, T. C.M., Boormans, J. L., Rutten, V. C., Salhi, Y., Robbrecht, G. J., de Wit, R., van Leenders, G. J.L.H., Zuiverloon, T. C.M., and Boormans, J. L.

Abstract

Background: Patients with locally advanced irresectable or clinically node positive urothelial cancer (UC) have a poor outcome. Currently, these patients can only be cured by receiving induction chemotherapy and, if an adequate radiological response is obtained, radical surgical resection. Long-term survival, however, strongly depends on the absence of residual tumor in the surgical resection specimen, i.e. a pathological complete response (pCR). The reported pCR rate following induction chemotherapy in locally advanced or clinically node-positive UC is 15%. The 5-year overall survival rate for patients achieving a pCR is 70–80% versus 20% for patients who have residual disease or nodal metastases. This clearly demonstrates the unmet need to improve clinical outcome of these patients. Recently, the JAVELIN Bladder 100 study demonstrated an overall survival benefit of sequential chemo-immunotherapy in patients with metastatic UC. The CHASIT study aims to translate these findings to the induction setting by assessing the efficacy and safety of sequential chemo-immunotherapy in patients with locally advanced or clinically node-positive UC. In addition, patient biomaterials are collected to investigate biological mechanisms of response and resistance to chemo-immunotherapy. Methods: This multicenter, prospective phase II clinical trial includes patients with stage cT4NxM0 or cTxN1-N3M0 UC of the bladder, upper urinary tract or urethra. Patients who do not experience disease progression after 3 or 4 cycles of platinum-based chemotherapy are eligible for inclusion. Included patients receive 3 cycles of anti-PD-1 immunotherapy with avelumab followed by radical surgery. Primary endpoint is the pCR rate. It is hypothesized that sequential chemo-immunotherapy results in a pCR rate of ≥ 30%. To obtain a power of 80%, 64 patients are screened and 58 patients are included in the efficacy analysis. Secondary endpoints are toxicity, postoperative surgical complications, progres

Published
2023

2. Calf and dam characteristics and calf transport age affect immunoglobulin titers and hematological parameters of veal calves

Author

Afd methoden en statistieken, dI&I RA-I&I I&I, Immunologie, FAH theoretische epidemiologie, dFAH I&I, Marcato, F, van den Brand, H, Kemp, B, Engel, B, Schnabel, S K, Jansen, C A, Rutten, V P M G, Koets, A P, Hoorweg, F A, de Vries-Reilingh, G, Wulansari, A, Wolthuis-Fillerup, M, van Reenen, K, Afd methoden en statistieken, dI&I RA-I&I I&I, Immunologie, FAH theoretische epidemiologie, dFAH I&I, Marcato, F, van den Brand, H, Kemp, B, Engel, B, Schnabel, S K, Jansen, C A, Rutten, V P M G, Koets, A P, Hoorweg, F A, de Vries-Reilingh, G, Wulansari, A, Wolthuis-Fillerup, M, and van Reenen, K

Published
2022

3. Calf and dam characteristics and calf transport age affect immunoglobulin titers and hematological parameters of veal calves

Author

Afd methoden en statistieken, dI&I RA-I&I I&I, Immunologie, FAH theoretische epidemiologie, dFAH I&I, Marcato, F, van den Brand, H, Kemp, B, Engel, B, Schnabel, S K, Jansen, C A, Rutten, V P M G, Koets, A P, Hoorweg, F A, de Vries-Reilingh, G, Wulansari, A, Wolthuis-Fillerup, M, van Reenen, K, Afd methoden en statistieken, dI&I RA-I&I I&I, Immunologie, FAH theoretische epidemiologie, dFAH I&I, Marcato, F, van den Brand, H, Kemp, B, Engel, B, Schnabel, S K, Jansen, C A, Rutten, V P M G, Koets, A P, Hoorweg, F A, de Vries-Reilingh, G, Wulansari, A, Wolthuis-Fillerup, M, and van Reenen, K

Published
2022

4. Calf and dam characteristics and calf transport age affect immunoglobulin titers and hematological parameters of veal calves

Author

Afd methoden en statistieken, dI&I RA-I&I I&I, Immunologie, FAH theoretische epidemiologie, dFAH I&I, Marcato, F, van den Brand, H, Kemp, B, Engel, B, Schnabel, S K, Jansen, C A, Rutten, V P M G, Koets, A P, Hoorweg, F A, de Vries-Reilingh, G, Wulansari, A, Wolthuis-Fillerup, M, van Reenen, K, Afd methoden en statistieken, dI&I RA-I&I I&I, Immunologie, FAH theoretische epidemiologie, dFAH I&I, Marcato, F, van den Brand, H, Kemp, B, Engel, B, Schnabel, S K, Jansen, C A, Rutten, V P M G, Koets, A P, Hoorweg, F A, de Vries-Reilingh, G, Wulansari, A, Wolthuis-Fillerup, M, and van Reenen, K

Published
2022

5. Elephant Endotheliotropic Herpesvirus Is Omnipresent in Elephants in European Zoos and an Asian Elephant Range Country

Author

Hoornweg, TE, Schaftenaar, W, Maurer, G, van den Doel, Petra, Molenaar, FM, Chamouard-Galante, A, Vercammen, F, Rutten, V, de Haan, CAM, Hoornweg, TE, Schaftenaar, W, Maurer, G, van den Doel, Petra, Molenaar, FM, Chamouard-Galante, A, Vercammen, F, Rutten, V, and de Haan, CAM

Abstract

Elephant endotheliotropic herpesviruses (EEHVs) may cause acute, often lethal, hemor-rhagic disease (EEHV-HD) in young elephants. Prevalence of EEHV in different elephant populations is still largely unknown. In order to improve diagnostic tools for the detection of EEHV infections and to obtain insight into its spread among elephants, we developed novel ELISAs based on EEHV1A gB and gH/gL. Performance of the ELISAs was assessed using sera from 41 European zoo elephants and 69 semi-captive elephants from Laos, one of the Asian elephant range countries. Sera from all (sub)adult animals tested (≥5 years of age) showed high reactivity with both gB and gH/gL, indicating that EEHV prevalence has been highly underestimated so far. Reactivity towards the antigens was generally lower for sera of juvenile animals (1 > 5 years). Only one (juvenile) animal, which was sampled directly after succumbing to EEHV-HD, was found to be seronegative for EEHV. The two other EEHV-HD cases tested showed low antibody levels, suggesting that all three cases died upon a primary EEHV infection. In conclusion, our study suggests that essentially all (semi-)captive (sub)adult elephants in European zoos and in Laos carry EEHV, and that young elephants with low antibody levels are at risk of dying from EEHV-HD.

Published
2021

6. Evidence of high EEHV antibody seroprevalence and spatial variation among captive Asian elephants (Elephas maximus) in Thailand

Author

Angkawanish, T., Nielen, M.M.A. (Marjan), Vernooij, H., Brown, J.L., Kooten, P.J.S. (Peter) van, Doel, P. (Petra) van den, Schaftenaar, W. (Willem), Lampang, K.N., Rutten, V., Angkawanish, T., Nielen, M.M.A. (Marjan), Vernooij, H., Brown, J.L., Kooten, P.J.S. (Peter) van, Doel, P. (Petra) van den, Schaftenaar, W. (Willem), Lampang, K.N., and Rutten, V.

Abstract

Background Elephant endotheliotropic herpesviruses (EEHV) can cause an acute highly fatal hemorrhagic disease in young Asian elephants (Elephas maximus), both ex situ and in situ. Amongst eight EEHV types described so far, type 1 (subtype 1A and 1B) is the predominant disease-associated type. Little is known about routes of infection and pathogenesis of EEHV, and knowledge of disease prevalence, especially in range countries, is limited. Methods A large cross-sectional serological survey was conducted in captive elephants (n = 994) throughout Thailand using an EEHV-1A glycoprotein B protein antigen specific antibody ELISA. Results Antibody seroprevalence was 42.3%, with 420 of 994 elephants testing positive. Associations between seropositivity and potential risk factors for EEHV infection were assessed and included: elephant age, sex, camp cluster size, management type (extensive versus intensive), sampling period (wet vs. dry season) and location of camp (region). Univariable regression analysis identified management system and region as risk factors for the presence of EEHV antibodies in elephants, with region being significant in the final multivariable regression model. Prevalence was highest in the North region of the country (49.4%). Conclusions This study produced baseline serological data for captive elephants throughout Thailand, and showed a significant EEHV burden likely to be maintained in the captive population.

Published
2019
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7. Differences between Staphylococcus aureus lineages isolated from ovine and caprine mastitis but not between isolates from clinical or subclinical mastitis

Author

LS GZ Landbouwhuisdieren, dFAH I&I, Immunologie, dI&I RA-I&I I&I, LS Immunologie, Sub Immunologie, dFAH AVR, Hoekstra, J, Rutten, V P M G, van den Hout, M, Spaninks, M P, Benedictus, L, Koop, G, LS GZ Landbouwhuisdieren, dFAH I&I, Immunologie, dI&I RA-I&I I&I, LS Immunologie, Sub Immunologie, dFAH AVR, Hoekstra, J, Rutten, V P M G, van den Hout, M, Spaninks, M P, Benedictus, L, and Koop, G

Published
2019

8. Differences between Staphylococcus aureus lineages isolated from ovine and caprine mastitis but not between isolates from clinical or subclinical mastitis

Author

LS GZ Landbouwhuisdieren, dFAH I&I, Immunologie, dI&I RA-I&I I&I, LS Immunologie, Sub Immunologie, dFAH AVR, Hoekstra, J, Rutten, V P M G, van den Hout, M, Spaninks, M P, Benedictus, L, Koop, G, LS GZ Landbouwhuisdieren, dFAH I&I, Immunologie, dI&I RA-I&I I&I, LS Immunologie, Sub Immunologie, dFAH AVR, Hoekstra, J, Rutten, V P M G, van den Hout, M, Spaninks, M P, Benedictus, L, and Koop, G

Published
2019

9. Differences between Staphylococcus aureus lineages isolated from ovine and caprine mastitis but not between isolates from clinical or subclinical mastitis

Author

LS GZ Landbouwhuisdieren, dFAH I&I, Immunologie, dI&I RA-I&I I&I, LS Immunologie, Sub Immunologie, dFAH AVR, Hoekstra, J, Rutten, V P M G, van den Hout, M, Spaninks, M P, Benedictus, L, Koop, G, LS GZ Landbouwhuisdieren, dFAH I&I, Immunologie, dI&I RA-I&I I&I, LS Immunologie, Sub Immunologie, dFAH AVR, Hoekstra, J, Rutten, V P M G, van den Hout, M, Spaninks, M P, Benedictus, L, and Koop, G

Published
2019

11. Cross reactive immune responses in cattle arising from exposure to Mycobacterium bovis and non-tuberculous mycobacteria

Author

LS Immunologie, Dep Infectieziekten Immunologie, dI&I RA-I&I I&I, Jenkins, A. O., Gormley, E., Gcebe, N., Fosgate, G T, Conan, A., Aagaard, C., Michel, A. L., Rutten, V. P.M.G., LS Immunologie, Dep Infectieziekten Immunologie, dI&I RA-I&I I&I, Jenkins, A. O., Gormley, E., Gcebe, N., Fosgate, G T, Conan, A., Aagaard, C., Michel, A. L., and Rutten, V. P.M.G.

Published
2018

12. Knowledge gaps that hamper prevention and control of Mycobacterium avium subspecies paratuberculosis infection

Author

Sub GZ Herkauwer, dFAH I&I, Sub Immunologie, dI&I RA-I&I I&I, LS Immunologie, Dep Gezondheidszorg Landbouwhuisdieren, Barkema, Herman W, Orsel, K., Nielsen, S., Koets, A. P., Rutten, V. P.M.G., Bannantine, J P, Keefe, G P, Kelton, D F, Wells, S J, Whittington, R J, Mackintosh, C.G., Manning, E J, Weber, M. F., Heuer, C., Forde, T L, Ritter, Caroline, Roche, Steven, Corbett, C S, Wolf, R., Griebel, P J, Kastelic, J P, Buck, J., Sub GZ Herkauwer, dFAH I&I, Sub Immunologie, dI&I RA-I&I I&I, LS Immunologie, Dep Gezondheidszorg Landbouwhuisdieren, Barkema, Herman W, Orsel, K., Nielsen, S., Koets, A. P., Rutten, V. P.M.G., Bannantine, J P, Keefe, G P, Kelton, D F, Wells, S J, Whittington, R J, Mackintosh, C.G., Manning, E J, Weber, M. F., Heuer, C., Forde, T L, Ritter, Caroline, Roche, Steven, Corbett, C S, Wolf, R., Griebel, P J, Kastelic, J P, and Buck, J.

Published
2018

13. Characterization of Staphylococcus aureus isolated from milk samples of dairy cows in small holder farms of North-Western Ethiopia

Author

LS GZ Landbouwhuisdieren, dFAH AVR, dFAH I&I, dI&I RA-I&I I&I, LS Immunologie, LS Klinisch Onderzoek Wagenaar, dI&I I&I-4, Sub Immunologie, Mekonnen, S A, Lam, T J G M, Hoekstra, J, Rutten, V P M G, Tessema, T S, Broens, E M, Riesebos, A E, Spaninks, M P, Koop, G, LS GZ Landbouwhuisdieren, dFAH AVR, dFAH I&I, dI&I RA-I&I I&I, LS Immunologie, LS Klinisch Onderzoek Wagenaar, dI&I I&I-4, Sub Immunologie, Mekonnen, S A, Lam, T J G M, Hoekstra, J, Rutten, V P M G, Tessema, T S, Broens, E M, Riesebos, A E, Spaninks, M P, and Koop, G

Published
2018

14. Prevalence of bovine tuberculosis in cattle, goats, and camels of traditional livestock raising communities in Eritrea

Author

dFAH AVR, Dep Infectieziekten Immunologie, LS Theoretische Epidemiologie, LS Evidence Based Vet Medicine, dI&I RA-I&I I&I, LS Immunologie, Ghebremariam, Michael K, Michel, A. L., Vernooij, J. C.M., Nielen, M., Rutten, V. P.M.G., dFAH AVR, Dep Infectieziekten Immunologie, LS Theoretische Epidemiologie, LS Evidence Based Vet Medicine, dI&I RA-I&I I&I, LS Immunologie, Ghebremariam, Michael K, Michel, A. L., Vernooij, J. C.M., Nielen, M., and Rutten, V. P.M.G.

Published
2018

15. Farm-level risk factors associated with bovine tuberculosis in the dairy sector in Eritrea

Author

dFAH AVR, LS Evidence Based Vet Medicine, Dep Infectieziekten Immunologie, LS Theoretische Epidemiologie, dI&I RA-I&I I&I, LS Immunologie, Ghebremariam, M K, Michel, A L, Nielen, M, Vernooij, J C M, Rutten, V P M G, dFAH AVR, LS Evidence Based Vet Medicine, Dep Infectieziekten Immunologie, LS Theoretische Epidemiologie, dI&I RA-I&I I&I, LS Immunologie, Ghebremariam, M K, Michel, A L, Nielen, M, Vernooij, J C M, and Rutten, V P M G

Published
2018

16. Cross reactive immune responses in cattle arising from exposure to Mycobacterium bovis and non-tuberculous mycobacteria

Author

LS Immunologie, Dep Infectieziekten Immunologie, dI&I RA-I&I I&I, Jenkins, A. O., Gormley, E., Gcebe, N., Fosgate, G T, Conan, A., Aagaard, C., Michel, A. L., Rutten, V. P.M.G., LS Immunologie, Dep Infectieziekten Immunologie, dI&I RA-I&I I&I, Jenkins, A. O., Gormley, E., Gcebe, N., Fosgate, G T, Conan, A., Aagaard, C., Michel, A. L., and Rutten, V. P.M.G.

Published
2018

17. Knowledge gaps that hamper prevention and control of Mycobacterium avium subspecies paratuberculosis infection

Author

Sub GZ Herkauwer, dFAH I&I, Sub Immunologie, dI&I RA-I&I I&I, LS Immunologie, Dep Gezondheidszorg Landbouwhuisdieren, Barkema, Herman W, Orsel, K., Nielsen, S., Koets, A. P., Rutten, V. P.M.G., Bannantine, J P, Keefe, G P, Kelton, D F, Wells, S J, Whittington, R J, Mackintosh, C.G., Manning, E J, Weber, M. F., Heuer, C., Forde, T L, Ritter, Caroline, Roche, Steven, Corbett, C S, Wolf, R., Griebel, P J, Kastelic, J P, Buck, J., Sub GZ Herkauwer, dFAH I&I, Sub Immunologie, dI&I RA-I&I I&I, LS Immunologie, Dep Gezondheidszorg Landbouwhuisdieren, Barkema, Herman W, Orsel, K., Nielsen, S., Koets, A. P., Rutten, V. P.M.G., Bannantine, J P, Keefe, G P, Kelton, D F, Wells, S J, Whittington, R J, Mackintosh, C.G., Manning, E J, Weber, M. F., Heuer, C., Forde, T L, Ritter, Caroline, Roche, Steven, Corbett, C S, Wolf, R., Griebel, P J, Kastelic, J P, and Buck, J.

Published
2018

18. Prevalence of bovine tuberculosis in cattle, goats, and camels of traditional livestock raising communities in Eritrea

Author

dFAH AVR, Dep Infectieziekten Immunologie, LS Theoretische Epidemiologie, LS Evidence Based Vet Medicine, dI&I RA-I&I I&I, LS Immunologie, Ghebremariam, Michael K, Michel, A. L., Vernooij, J. C.M., Nielen, M., Rutten, V. P.M.G., dFAH AVR, Dep Infectieziekten Immunologie, LS Theoretische Epidemiologie, LS Evidence Based Vet Medicine, dI&I RA-I&I I&I, LS Immunologie, Ghebremariam, Michael K, Michel, A. L., Vernooij, J. C.M., Nielen, M., and Rutten, V. P.M.G.

Published
2018

19. Farm-level risk factors associated with bovine tuberculosis in the dairy sector in Eritrea

Author

dFAH AVR, LS Evidence Based Vet Medicine, Dep Infectieziekten Immunologie, LS Theoretische Epidemiologie, dI&I RA-I&I I&I, LS Immunologie, Ghebremariam, M K, Michel, A L, Nielen, M, Vernooij, J C M, Rutten, V P M G, dFAH AVR, LS Evidence Based Vet Medicine, Dep Infectieziekten Immunologie, LS Theoretische Epidemiologie, dI&I RA-I&I I&I, LS Immunologie, Ghebremariam, M K, Michel, A L, Nielen, M, Vernooij, J C M, and Rutten, V P M G

Published
2018

20. Characterization of Staphylococcus aureus isolated from milk samples of dairy cows in small holder farms of North-Western Ethiopia

Author

LS GZ Landbouwhuisdieren, dFAH AVR, dFAH I&I, dI&I RA-I&I I&I, LS Immunologie, LS Klinisch Onderzoek Wagenaar, dI&I I&I-4, Sub Immunologie, Mekonnen, S A, Lam, T J G M, Hoekstra, J, Rutten, V P M G, Tessema, T S, Broens, E M, Riesebos, A E, Spaninks, M P, Koop, G, LS GZ Landbouwhuisdieren, dFAH AVR, dFAH I&I, dI&I RA-I&I I&I, LS Immunologie, LS Klinisch Onderzoek Wagenaar, dI&I I&I-4, Sub Immunologie, Mekonnen, S A, Lam, T J G M, Hoekstra, J, Rutten, V P M G, Tessema, T S, Broens, E M, Riesebos, A E, Spaninks, M P, and Koop, G

Published
2018

21. Cross reactive immune responses in cattle arising from exposure to Mycobacterium bovis and non-tuberculous mycobacteria

Author

LS Immunologie, Dep Infectieziekten Immunologie, dI&I RA-I&I I&I, Jenkins, A. O., Gormley, E., Gcebe, N., Fosgate, G T, Conan, A., Aagaard, C., Michel, A. L., Rutten, V. P.M.G., LS Immunologie, Dep Infectieziekten Immunologie, dI&I RA-I&I I&I, Jenkins, A. O., Gormley, E., Gcebe, N., Fosgate, G T, Conan, A., Aagaard, C., Michel, A. L., and Rutten, V. P.M.G.

Published
2018

22. Knowledge gaps that hamper prevention and control of Mycobacterium avium subspecies paratuberculosis infection

Author

Sub GZ Herkauwer, dFAH I&I, Sub Immunologie, dI&I RA-I&I I&I, LS Immunologie, Dep Gezondheidszorg Landbouwhuisdieren, Barkema, Herman W, Orsel, K., Nielsen, S., Koets, A. P., Rutten, V. P.M.G., Bannantine, J P, Keefe, G P, Kelton, D F, Wells, S J, Whittington, R J, Mackintosh, C.G., Manning, E J, Weber, M. F., Heuer, C., Forde, T L, Ritter, Caroline, Roche, Steven, Corbett, C S, Wolf, R., Griebel, P J, Kastelic, J P, Buck, J., Sub GZ Herkauwer, dFAH I&I, Sub Immunologie, dI&I RA-I&I I&I, LS Immunologie, Dep Gezondheidszorg Landbouwhuisdieren, Barkema, Herman W, Orsel, K., Nielsen, S., Koets, A. P., Rutten, V. P.M.G., Bannantine, J P, Keefe, G P, Kelton, D F, Wells, S J, Whittington, R J, Mackintosh, C.G., Manning, E J, Weber, M. F., Heuer, C., Forde, T L, Ritter, Caroline, Roche, Steven, Corbett, C S, Wolf, R., Griebel, P J, Kastelic, J P, and Buck, J.

Published
2018

23. Characterization of Staphylococcus aureus isolated from milk samples of dairy cows in small holder farms of North-Western Ethiopia

Author

LS GZ Landbouwhuisdieren, dFAH AVR, dFAH I&I, dI&I RA-I&I I&I, LS Immunologie, LS Klinisch Onderzoek Wagenaar, dI&I I&I-4, Sub Immunologie, Mekonnen, S A, Lam, T J G M, Hoekstra, J, Rutten, V P M G, Tessema, T S, Broens, E M, Riesebos, A E, Spaninks, M P, Koop, G, LS GZ Landbouwhuisdieren, dFAH AVR, dFAH I&I, dI&I RA-I&I I&I, LS Immunologie, LS Klinisch Onderzoek Wagenaar, dI&I I&I-4, Sub Immunologie, Mekonnen, S A, Lam, T J G M, Hoekstra, J, Rutten, V P M G, Tessema, T S, Broens, E M, Riesebos, A E, Spaninks, M P, and Koop, G

Published
2018

24. Prevalence of bovine tuberculosis in cattle, goats, and camels of traditional livestock raising communities in Eritrea

Author

dFAH AVR, Dep Infectieziekten Immunologie, LS Theoretische Epidemiologie, LS Evidence Based Vet Medicine, dI&I RA-I&I I&I, LS Immunologie, Ghebremariam, Michael K, Michel, A. L., Vernooij, J. C.M., Nielen, M., Rutten, V. P.M.G., dFAH AVR, Dep Infectieziekten Immunologie, LS Theoretische Epidemiologie, LS Evidence Based Vet Medicine, dI&I RA-I&I I&I, LS Immunologie, Ghebremariam, Michael K, Michel, A. L., Vernooij, J. C.M., Nielen, M., and Rutten, V. P.M.G.

Published
2018

25. Farm-level risk factors associated with bovine tuberculosis in the dairy sector in Eritrea

Author

dFAH AVR, LS Evidence Based Vet Medicine, Dep Infectieziekten Immunologie, LS Theoretische Epidemiologie, dI&I RA-I&I I&I, LS Immunologie, Ghebremariam, M K, Michel, A L, Nielen, M, Vernooij, J C M, Rutten, V P M G, dFAH AVR, LS Evidence Based Vet Medicine, Dep Infectieziekten Immunologie, LS Theoretische Epidemiologie, dI&I RA-I&I I&I, LS Immunologie, Ghebremariam, M K, Michel, A L, Nielen, M, Vernooij, J C M, and Rutten, V P M G

Published
2018

26. Knowledge gaps that hamper prevention and control of Mycobacterium avium subspecies paratuberculosis infection

Author

Barkema, H W, Orsel, K, Nielsen, S S, Koets, A P, Rutten, V P M G, Bannantine, J P, Keefe, G P, Kelton, D F, Wells, S J, Whittington, R J, Mackintosh, C G, Manning, E J, Weber, M F, Heuer, C, Forde, T L, Ritter, C, Roche, S, Corbett, C S, Wolf, R, Griebel, P J, Kastelic, J P, De Buck, J, Barkema, H W, Orsel, K, Nielsen, S S, Koets, A P, Rutten, V P M G, Bannantine, J P, Keefe, G P, Kelton, D F, Wells, S J, Whittington, R J, Mackintosh, C G, Manning, E J, Weber, M F, Heuer, C, Forde, T L, Ritter, C, Roche, S, Corbett, C S, Wolf, R, Griebel, P J, Kastelic, J P, and De Buck, J

Abstract

In the last decades, many regional and country-wide control programmes for Johne's disease (JD) were developed due to associated economic losses, or because of a possible association with Crohn's disease. These control programmes were often not successful, partly because management protocols were not followed, including the introduction of infected replacement cattle, because tests to identify infected animals were unreliable, and uptake by farmers was not high enough because of a perceived low return on investment. In the absence of a cure or effective commercial vaccines, control of JD is currently primarily based on herd management strategies to avoid infection of cattle and restrict within-farm and farm-to-farm transmission. Although JD control programmes have been implemented in most developed countries, lessons learned from JD prevention and control programmes are underreported. Also, JD control programmes are typically evaluated in a limited number of herds and the duration of the study is less than 5 year, making it difficult to adequately assess the efficacy of control programmes. In this manuscript, we identify the most important gaps in knowledge hampering JD prevention and control programmes, including vaccination and diagnostics. Secondly, we discuss directions that research should take to address those knowledge gaps.

Published
2018

27. In vitro and in vivo effects of kisspeptin antagonists p234, p271, p354, and p356 on GPR54 activation

Author

dCSCA AVR, dI&I RA-I&I I&I, CSCA AVM, dCSCA RMSC-1, dES/dFAH FR, Albers-Wolthers, C H J, de Gier, J, Walen, M, van Kooten, P J S, Lambalk, C B, Leegwater, P A J, Roelen, B A J, Schaefers-Okkens, A C, Rutten, V P M G, Millar, R P M, Kooistra, H S, dCSCA AVR, dI&I RA-I&I I&I, CSCA AVM, dCSCA RMSC-1, dES/dFAH FR, Albers-Wolthers, C H J, de Gier, J, Walen, M, van Kooten, P J S, Lambalk, C B, Leegwater, P A J, Roelen, B A J, Schaefers-Okkens, A C, Rutten, V P M G, Millar, R P M, and Kooistra, H S

Published
2017

32. In vitro and in vivo effects of kisspeptin antagonists p234, p271, p354, and p356 on GPR54 activation

Author

dCSCA AVR, dI&I RA-I&I I&I, CSCA AVM, dCSCA RMSC-1, dES/dFAH FR, Albers-Wolthers, C H J, de Gier, J, Walen, M, van Kooten, P J S, Lambalk, C B, Leegwater, P A J, Roelen, B A J, Schaefers-Okkens, A C, Rutten, V P M G, Millar, R P M, Kooistra, H S, dCSCA AVR, dI&I RA-I&I I&I, CSCA AVM, dCSCA RMSC-1, dES/dFAH FR, Albers-Wolthers, C H J, de Gier, J, Walen, M, van Kooten, P J S, Lambalk, C B, Leegwater, P A J, Roelen, B A J, Schaefers-Okkens, A C, Rutten, V P M G, Millar, R P M, and Kooistra, H S

Published
2017

35. In vitro and in vivo effects of kisspeptin antagonists p234, p271, p354, and p356 on GPR54 activation

Author

dCSCA AVR, dI&I RA-I&I I&I, CSCA AVM, dCSCA RMSC-1, dES/dFAH FR, Albers-Wolthers, C H J, de Gier, J, Walen, M, van Kooten, P J S, Lambalk, C B, Leegwater, P A J, Roelen, B A J, Schaefers-Okkens, A C, Rutten, V P M G, Millar, R P M, Kooistra, H S, dCSCA AVR, dI&I RA-I&I I&I, CSCA AVM, dCSCA RMSC-1, dES/dFAH FR, Albers-Wolthers, C H J, de Gier, J, Walen, M, van Kooten, P J S, Lambalk, C B, Leegwater, P A J, Roelen, B A J, Schaefers-Okkens, A C, Rutten, V P M G, Millar, R P M, and Kooistra, H S

Published
2017

36. Reisolation of Staphylococcus aureus from bovine milk following experimental inoculation is influenced by fat percentage and specific immunoglobulin G1 titer in milk

Author

Sub Immunologie, LS Theoretische Epidemiologie, LS Immunologie, dFAH I&I, Boerhout, E M, Koets, A P, Vernooij, J C M, Mols-Vorstermans, T G T, Nuijten, P J M, Rutten, V P M G, Bijlsma, J J E, Eisenberg, S W F, Sub Immunologie, LS Theoretische Epidemiologie, LS Immunologie, dFAH I&I, Boerhout, E M, Koets, A P, Vernooij, J C M, Mols-Vorstermans, T G T, Nuijten, P J M, Rutten, V P M G, Bijlsma, J J E, and Eisenberg, S W F

Published
2016

37. Diurnal differences in milk composition and its influence on in vitro growth of Staphylococcus aureus and Escherichia coli in bovine quarter milk

Author

Sub Immunologie, Dep Infectieziekten Immunologie, LS Immunologie, dFAH I&I, Eisenberg, S W F, Boerhout, E M, Ravesloot, L, Daemen, A J J M, Benedictus, L, Rutten, V P M G, Koets, A P, Sub Immunologie, Dep Infectieziekten Immunologie, LS Immunologie, dFAH I&I, Eisenberg, S W F, Boerhout, E M, Ravesloot, L, Daemen, A J J M, Benedictus, L, Rutten, V P M G, and Koets, A P

Published
2016

38. The effects of kisspeptin agonist canine KP-10 and kisspeptin antagonist p271 on plasma LH concentrations during different stages of the estrous cycle and anestrus in the bitch

Author

Sub Voortplanting, LS Immunologie, Onderzoek, Sub Endocrinologie, dCSCA AVR, Albers-Wolthers, C H J, de Gier, J, Rutten, V P M G, van Kooten, P J S, Leegwater, P A J, Schaefers-Okkens, A C, Kooistra, H S, Sub Voortplanting, LS Immunologie, Onderzoek, Sub Endocrinologie, dCSCA AVR, Albers-Wolthers, C H J, de Gier, J, Rutten, V P M G, van Kooten, P J S, Leegwater, P A J, Schaefers-Okkens, A C, and Kooistra, H S

Published
2016

39. Prevalence and risk factors of bovine tuberculosis in dairy cattle in Eritrea

Author

LS Immunologie, LS Theoretische Epidemiologie, dFAH AVR, dI&I RA-I&I I&I, Applied Veterinary Research, Infection & Immunity, Ghebremariam, Michael K, Rutten, V P M G, Vernooij, J C M, Uqbazghi, K, Tesfaalem, T, Butsuamlak, T, Idris, A M, Nielen, M, Michel, A L, LS Immunologie, LS Theoretische Epidemiologie, dFAH AVR, dI&I RA-I&I I&I, Applied Veterinary Research, Infection & Immunity, Ghebremariam, Michael K, Rutten, V P M G, Vernooij, J C M, Uqbazghi, K, Tesfaalem, T, Butsuamlak, T, Idris, A M, Nielen, M, and Michel, A L

Published
2016

40. Reisolation of Staphylococcus aureus from bovine milk following experimental inoculation is influenced by fat percentage and specific immunoglobulin G1 titer in milk

Author

Sub Immunologie, LS Theoretische Epidemiologie, LS Immunologie, dFAH I&I, Boerhout, E M, Koets, A P, Vernooij, J C M, Mols-Vorstermans, T G T, Nuijten, P J M, Rutten, V P M G, Bijlsma, J J E, Eisenberg, S W F, Sub Immunologie, LS Theoretische Epidemiologie, LS Immunologie, dFAH I&I, Boerhout, E M, Koets, A P, Vernooij, J C M, Mols-Vorstermans, T G T, Nuijten, P J M, Rutten, V P M G, Bijlsma, J J E, and Eisenberg, S W F

Published
2016

41. The effects of kisspeptin agonist canine KP-10 and kisspeptin antagonist p271 on plasma LH concentrations during different stages of the estrous cycle and anestrus in the bitch

Author

Sub Voortplanting, LS Immunologie, Onderzoek, Sub Endocrinologie, dCSCA AVR, Albers-Wolthers, C H J, de Gier, J, Rutten, V P M G, van Kooten, P J S, Leegwater, P A J, Schaefers-Okkens, A C, Kooistra, H S, Sub Voortplanting, LS Immunologie, Onderzoek, Sub Endocrinologie, dCSCA AVR, Albers-Wolthers, C H J, de Gier, J, Rutten, V P M G, van Kooten, P J S, Leegwater, P A J, Schaefers-Okkens, A C, and Kooistra, H S

Published
2016

42. Prevalence and risk factors of bovine tuberculosis in dairy cattle in Eritrea

Author

LS Immunologie, LS Theoretische Epidemiologie, dFAH AVR, dI&I RA-I&I I&I, Applied Veterinary Research, Infection & Immunity, Ghebremariam, Michael K, Rutten, V P M G, Vernooij, J C M, Uqbazghi, K, Tesfaalem, T, Butsuamlak, T, Idris, A M, Nielen, M, Michel, A L, LS Immunologie, LS Theoretische Epidemiologie, dFAH AVR, dI&I RA-I&I I&I, Applied Veterinary Research, Infection & Immunity, Ghebremariam, Michael K, Rutten, V P M G, Vernooij, J C M, Uqbazghi, K, Tesfaalem, T, Butsuamlak, T, Idris, A M, Nielen, M, and Michel, A L

Published
2016

43. Diurnal differences in milk composition and its influence on in vitro growth of Staphylococcus aureus and Escherichia coli in bovine quarter milk

Author

Sub Immunologie, Dep Infectieziekten Immunologie, LS Immunologie, dFAH I&I, Eisenberg, S W F, Boerhout, E M, Ravesloot, L, Daemen, A J J M, Benedictus, L, Rutten, V P M G, Koets, A P, Sub Immunologie, Dep Infectieziekten Immunologie, LS Immunologie, dFAH I&I, Eisenberg, S W F, Boerhout, E M, Ravesloot, L, Daemen, A J J M, Benedictus, L, Rutten, V P M G, and Koets, A P

Published
2016

44. Reisolation of Staphylococcus aureus from bovine milk following experimental inoculation is influenced by fat percentage and specific immunoglobulin G1 titer in milk

Author

Sub Immunologie, LS Theoretische Epidemiologie, LS Immunologie, dFAH I&I, Boerhout, E M, Koets, A P, Vernooij, J C M, Mols-Vorstermans, T G T, Nuijten, P J M, Rutten, V P M G, Bijlsma, J J E, Eisenberg, S W F, Sub Immunologie, LS Theoretische Epidemiologie, LS Immunologie, dFAH I&I, Boerhout, E M, Koets, A P, Vernooij, J C M, Mols-Vorstermans, T G T, Nuijten, P J M, Rutten, V P M G, Bijlsma, J J E, and Eisenberg, S W F

Published
2016

45. The effects of kisspeptin agonist canine KP-10 and kisspeptin antagonist p271 on plasma LH concentrations during different stages of the estrous cycle and anestrus in the bitch

Author

Sub Voortplanting, LS Immunologie, Onderzoek, Sub Endocrinologie, dCSCA AVR, Albers-Wolthers, C H J, de Gier, J, Rutten, V P M G, van Kooten, P J S, Leegwater, P A J, Schaefers-Okkens, A C, Kooistra, H S, Sub Voortplanting, LS Immunologie, Onderzoek, Sub Endocrinologie, dCSCA AVR, Albers-Wolthers, C H J, de Gier, J, Rutten, V P M G, van Kooten, P J S, Leegwater, P A J, Schaefers-Okkens, A C, and Kooistra, H S

Published
2016

46. Diurnal differences in milk composition and its influence on in vitro growth of Staphylococcus aureus and Escherichia coli in bovine quarter milk

Author

Sub Immunologie, Dep Infectieziekten Immunologie, LS Immunologie, dFAH I&I, Eisenberg, S W F, Boerhout, E M, Ravesloot, L, Daemen, A J J M, Benedictus, L, Rutten, V P M G, Koets, A P, Sub Immunologie, Dep Infectieziekten Immunologie, LS Immunologie, dFAH I&I, Eisenberg, S W F, Boerhout, E M, Ravesloot, L, Daemen, A J J M, Benedictus, L, Rutten, V P M G, and Koets, A P

Published
2016

47. Prevalence and risk factors of bovine tuberculosis in dairy cattle in Eritrea

Author

LS Immunologie, LS Theoretische Epidemiologie, dFAH AVR, dI&I RA-I&I I&I, Applied Veterinary Research, Infection & Immunity, Ghebremariam, Michael K, Rutten, V P M G, Vernooij, J C M, Uqbazghi, K, Tesfaalem, T, Butsuamlak, T, Idris, A M, Nielen, M, Michel, A L, LS Immunologie, LS Theoretische Epidemiologie, dFAH AVR, dI&I RA-I&I I&I, Applied Veterinary Research, Infection & Immunity, Ghebremariam, Michael K, Rutten, V P M G, Vernooij, J C M, Uqbazghi, K, Tesfaalem, T, Butsuamlak, T, Idris, A M, Nielen, M, and Michel, A L

Published
2016

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