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BACKGROUND: Penetrating trauma to the head and neck (HN) has increased during the past decade in Sweden. This aim of this study was to characterize these injuries and to evaluate the outcome in patients treated at a tertiary trauma centre. METHODS: Swedish trauma registry (SweTrau) data was extracted on patients with HN injuries admitted to Karolinska University Hospital, Stockholm, between 2011 and 2019. Outcome information was extracted from hospital records, with primary endpoints focusing of physiological outcome measures and secondary endpoints on surgical and radiological outcomes. RESULTS: Of 1436 penetrating trauma patients, 329 patients with penetrating HN injuries were identified. 20% (n=66) suffered a gunshot wound (GSW), 73% (n=240) a stab wound (SW), and 7% (n=23) other trauma mechanisms (OTM). The median age for GSW, SW and OTM were 25, 33, and 21, respectively. Assault was primary intent, GSW (81.8%, n=54) and SW (65.8%, n=158). Patients suffering GSWs had severer injuries, worse admission GCS-M and higher intubation rate at the injury site. Most GSW patients underwent major surgery (59.1%) as an initial procedure and more likely had intracranial haemorrhage (ICH) (21.2%). The 30-day mortality: 45.5% (n=30) for GSWs, 5.4% (n=13) for SWs and 0% (n=0) for OTMs. There was a yearly increase in incidence and mortality for GSW and SW. CONCLUSION: Between 2011 and 2019, there was an increasing yearly trend of incidence and mortality from penetrating HN trauma in Stockholm, Sweden. GSW patients suffered more severe injuries, ICHs, and underwent more surgical interventions compared to SW and OTM.

BACKGROUND: Penetrating trauma to the head and neck (HN) has increased during the past decade in Sweden. This aim of this study was to characterize these injuries and to evaluate the outcome in patients treated at a tertiary trauma centre. METHODS: Swedish trauma registry (SweTrau) data was extracted on patients with HN injuries admitted to Karolinska University Hospital, Stockholm, between 2011 and 2019. Outcome information was extracted from hospital records, with primary endpoints focusing of physiological outcome measures and secondary endpoints on surgical and radiological outcomes. RESULTS: Of 1436 penetrating trauma patients, 329 patients with penetrating HN injuries were identified. 20% (n=66) suffered a gunshot wound (GSW), 73% (n=240) a stab wound (SW), and 7% (n=23) other trauma mechanisms (OTM). The median age for GSW, SW and OTM were 25, 33, and 21, respectively. Assault was primary intent, GSW (81.8%, n=54) and SW (65.8%, n=158). Patients suffering GSWs had severer injuries, worse admission GCS-M and higher intubation rate at the injury site. Most GSW patients underwent major surgery (59.1%) as an initial procedure and more likely had intracranial haemorrhage (ICH) (21.2%). The 30-day mortality: 45.5% (n=30) for GSWs, 5.4% (n=13) for SWs and 0% (n=0) for OTMs. There was a yearly increase in incidence and mortality for GSW and SW. CONCLUSION: Between 2011 and 2019, there was an increasing yearly trend of incidence and mortality from penetrating HN trauma in Stockholm, Sweden. GSW patients suffered more severe injuries, ICHs, and underwent more surgical interventions compared to SW and OTM.

Personalized Food Recommendation Systems (Food-RecSys) are recognized for their potential to enhance dietary practices and address pressing health issues. Despite their promise, current food recommendation methodologies, predominantly rule-based and classification-driven, encounter substantial barriers in achieving practical applicability. This challenge is largely attributed to two main factors: the poor understanding of food recommendation specific components as a whole and inadequate research on a holistic integration between all the key components which enables the final methodology to achieve effective results, and also, the limitations of conventional machine learning models, which falter in the face of a virtually limitless array of food categories and the inherent imbalance within datasets. In this context, the advent of Large Language Models (LLMs) presents an intriguing alternative, suggesting a path forward for recommendation systems. Nevertheless, existing approaches that employ LLMs generally adopt a generic Recommendation as Language Processing (RLP) strategy, which falls short of incorporating the nuanced components essential for successful Food-RecSys.To bridge this research gap, this thesis provides a comprehensive overview on an intensely complex big picture, identifies the key components and provides innovative exploratory models for each the multiplex key components required for personalized contextual food recommendation, additionally, articulates a novel feasibility study of a comprehensive integrated personal contextual Food-RecSys framework, underpinned by several pivotal innovations aimed at fortifying the effectiveness of personalized food recommendations. Key among these is the development of a multimedia food logging platform and the World Food Atlas, the latter of which facilitates geolocation-based food queries—a capability notably absent in current offerings. Moreover, this work pioneers the Food Recommendation as Language Processing (

A common type of cancer treatment is chemotherapy, which involves using anticancer chemicals to kill cancerous cells. Despite all advances in chemotherapy, this method still has undesired side effects on healthy cells and suffers from nonspecific targeting. Dendrimers are nanoparticles capable of delivering drugs, DNA, and RNA to tumor cells without harming normal cells, so they have been utilized extensively in targeted cancer treatment. A dendrimer is a highly branched polymeric macromolecule with excellent physicochemical properties, intramolecular cavities, and easy surface modification. These structures can be applied as anticancer drug carriers through the entrapment of drugs in their internal voids or binding to the functional groups on their surface. In addition, further surface modifications, such as targeting ligands, can increase selectivity, delivery, and biocompatibility. This review will briefly summarize dendrimer’s history and focus on dendrimer-based nanotherapeutics for cancer therapy. In a nutshell, functionalized dendrimers are presented here as potential drug and gene carriers for cancer treatment.

Background Penetrating trauma to the head and neck has increased during the past decade in Sweden. The aim of this study was to characterize these injuries and evaluate the outcomes for patients treated at a tertiary trauma center. Methods Swedish trauma registry data were extracted on patients with head and neck injuries admitted to Karolinska University Hospital (Stockholm, Sweden) between 2011 and 2019. Outcome information was extracted from hospital records, with the primary endpoints focusing on the physiological outcome measures and the secondary endpoints on the surgical and radiological outcomes. Results Of 1436 patients with penetrating trauma, 329 with penetrating head and neck injuries were identified. Of the 329 patients, 66 (20%) had suffered a gunshot wound (GSW), 240 (73%) a stab wound (SW), and 23 (7%) an injury from other trauma mechanisms (OTMs). The median age for the corresponding 3 groups of patients was 25, 33, and 21 years, respectively. Assault was the primary intent, with 54 patients experiencing GSWs (81.8%) and 158 SWs (65.8%). Patients with GSWs had more severe injuries, worse admission Glasgow coma scale, motor, scores, and a higher intubation rate at the injury site. Most GSW patients underwent major surgery (59.1%) as the initial procedure and were more likely to have intracranial hemorrhage (21.2%). The 30-day mortality was 45.5% (n = 30) for GSWs, 5.4% (n = 13) for SWs, and 0% (n = 0) for OTMs. There was an annual increase in the incidence and mortality for GSWs and SWs. Conclusions Between 2011 and 2019, an increasing annual trend was found in the incidence and mortality from penetrating head and neck trauma in Stockholm, Sweden. GSW patients experienced more severe injuries and intracranial hemorrhage and underwent more surgical interventions compared with patients with SWs and OTMs.

Background Penetrating trauma to the head and neck has increased during the past decade in Sweden. The aim of this study was to characterize these injuries and evaluate the outcomes for patients treated at a tertiary trauma center. Methods Swedish trauma registry data were extracted on patients with head and neck injuries admitted to Karolinska University Hospital (Stockholm, Sweden) between 2011 and 2019. Outcome information was extracted from hospital records, with the primary endpoints focusing on the physiological outcome measures and the secondary endpoints on the surgical and radiological outcomes. Results Of 1436 patients with penetrating trauma, 329 with penetrating head and neck injuries were identified. Of the 329 patients, 66 (20%) had suffered a gunshot wound (GSW), 240 (73%) a stab wound (SW), and 23 (7%) an injury from other trauma mechanisms (OTMs). The median age for the corresponding 3 groups of patients was 25, 33, and 21 years, respectively. Assault was the primary intent, with 54 patients experiencing GSWs (81.8%) and 158 SWs (65.8%). Patients with GSWs had more severe injuries, worse admission Glasgow coma scale, motor, scores, and a higher intubation rate at the injury site. Most GSW patients underwent major surgery (59.1%) as the initial procedure and were more likely to have intracranial hemorrhage (21.2%). The 30-day mortality was 45.5% (n = 30) for GSWs, 5.4% (n = 13) for SWs, and 0% (n = 0) for OTMs. There was an annual increase in the incidence and mortality for GSWs and SWs. Conclusions Between 2011 and 2019, an increasing annual trend was found in the incidence and mortality from penetrating head and neck trauma in Stockholm, Sweden. GSW patients experienced more severe injuries and intracranial hemorrhage and underwent more surgical interventions compared with patients with SWs and OTMs.

Background Penetrating trauma to the head and neck has increased during the past decade in Sweden. The aim of this study was to characterize these injuries and evaluate the outcomes for patients treated at a tertiary trauma center. Methods Swedish trauma registry data were extracted on patients with head and neck injuries admitted to Karolinska University Hospital (Stockholm, Sweden) between 2011 and 2019. Outcome information was extracted from hospital records, with the primary endpoints focusing on the physiological outcome measures and the secondary endpoints on the surgical and radiological outcomes. Results Of 1436 patients with penetrating trauma, 329 with penetrating head and neck injuries were identified. Of the 329 patients, 66 (20%) had suffered a gunshot wound (GSW), 240 (73%) a stab wound (SW), and 23 (7%) an injury from other trauma mechanisms (OTMs). The median age for the corresponding 3 groups of patients was 25, 33, and 21 years, respectively. Assault was the primary intent, with 54 patients experiencing GSWs (81.8%) and 158 SWs (65.8%). Patients with GSWs had more severe injuries, worse admission Glasgow coma scale, motor, scores, and a higher intubation rate at the injury site. Most GSW patients underwent major surgery (59.1%) as the initial procedure and were more likely to have intracranial hemorrhage (21.2%). The 30-day mortality was 45.5% (n = 30) for GSWs, 5.4% (n = 13) for SWs, and 0% (n = 0) for OTMs. There was an annual increase in the incidence and mortality for GSWs and SWs. Conclusions Between 2011 and 2019, an increasing annual trend was found in the incidence and mortality from penetrating head and neck trauma in Stockholm, Sweden. GSW patients experienced more severe injuries and intracranial hemorrhage and underwent more surgical interventions compared with patients with SWs and OTMs.

Background Penetrating trauma to the head and neck has increased during the past decade in Sweden. The aim of this study was to characterize these injuries and evaluate the outcomes for patients treated at a tertiary trauma center. Methods Swedish trauma registry data were extracted on patients with head and neck injuries admitted to Karolinska University Hospital (Stockholm, Sweden) between 2011 and 2019. Outcome information was extracted from hospital records, with the primary endpoints focusing on the physiological outcome measures and the secondary endpoints on the surgical and radiological outcomes. Results Of 1436 patients with penetrating trauma, 329 with penetrating head and neck injuries were identified. Of the 329 patients, 66 (20%) had suffered a gunshot wound (GSW), 240 (73%) a stab wound (SW), and 23 (7%) an injury from other trauma mechanisms (OTMs). The median age for the corresponding 3 groups of patients was 25, 33, and 21 years, respectively. Assault was the primary intent, with 54 patients experiencing GSWs (81.8%) and 158 SWs (65.8%). Patients with GSWs had more severe injuries, worse admission Glasgow coma scale, motor, scores, and a higher intubation rate at the injury site. Most GSW patients underwent major surgery (59.1%) as the initial procedure and were more likely to have intracranial hemorrhage (21.2%). The 30-day mortality was 45.5% (n = 30) for GSWs, 5.4% (n = 13) for SWs, and 0% (n = 0) for OTMs. There was an annual increase in the incidence and mortality for GSWs and SWs. Conclusions Between 2011 and 2019, an increasing annual trend was found in the incidence and mortality from penetrating head and neck trauma in Stockholm, Sweden. GSW patients experienced more severe injuries and intracranial hemorrhage and underwent more surgical interventions compared with patients with SWs and OTMs.

BACKGROUND: Penetrating trauma to the head and neck (HN) has increased during the past decade in Sweden. This aim of this study was to characterize these injuries and to evaluate the outcome in patients treated at a tertiary trauma centre. METHODS: Swedish trauma registry (SweTrau) data was extracted on patients with HN injuries admitted to Karolinska University Hospital, Stockholm, between 2011 and 2019. Outcome information was extracted from hospital records, with primary endpoints focusing of physiological outcome measures and secondary endpoints on surgical and radiological outcomes. RESULTS: Of 1436 penetrating trauma patients, 329 patients with penetrating HN injuries were identified. 20% (n=66) suffered a gunshot wound (GSW), 73% (n=240) a stab wound (SW), and 7% (n=23) other trauma mechanisms (OTM). The median age for GSW, SW and OTM were 25, 33, and 21, respectively. Assault was primary intent, GSW (81.8%, n=54) and SW (65.8%, n=158). Patients suffering GSWs had severer injuries, worse admission GCS-M and higher intubation rate at the injury site. Most GSW patients underwent major surgery (59.1%) as an initial procedure and more likely had intracranial haemorrhage (ICH) (21.2%). The 30-day mortality: 45.5% (n=30) for GSWs, 5.4% (n=13) for SWs and 0% (n=0) for OTMs. There was a yearly increase in incidence and mortality for GSW and SW. CONCLUSION: Between 2011 and 2019, there was an increasing yearly trend of incidence and mortality from penetrating HN trauma in Stockholm, Sweden. GSW patients suffered more severe injuries, ICHs, and underwent more surgical interventions compared to SW and OTM.

Background: The early management of polytrauma patients with traumatic spinal cord injury (tSCI) is a major challenge. Sparse data is available to provide optimal care in this scenario and worldwide variability in clinical practice has been documented in recent studies. Methods: A multidisciplinary consensus panel of physicians selected for their established clinical and scientific expertise in the acute management of tSCI polytrauma patients with different specializations was established. The World Society of Emergency Surgery (WSES) and the European Association of Neurosurgical Societies (EANS) endorsed the consensus, and a modified Delphi approach was adopted. Results: A total of 17 statements were proposed and discussed. A consensus was reached generating 17 recommendations (16 strong and 1 weak). Conclusions: This consensus provides practical recommendations to support a clinician’s decision making in the management of tSCI polytrauma patients.

BACKGROUND: Penetrating trauma to the head and neck (HN) has increased during the past decade in Sweden. This aim of this study was to characterize these injuries and to evaluate the outcome in patients treated at a tertiary trauma centre. METHODS: Swedish trauma registry (SweTrau) data was extracted on patients with HN injuries admitted to Karolinska University Hospital, Stockholm, between 2011 and 2019. Outcome information was extracted from hospital records, with primary endpoints focusing of physiological outcome measures and secondary endpoints on surgical and radiological outcomes. RESULTS: Of 1436 penetrating trauma patients, 329 patients with penetrating HN injuries were identified. 20% (n=66) suffered a gunshot wound (GSW), 73% (n=240) a stab wound (SW), and 7% (n=23) other trauma mechanisms (OTM). The median age for GSW, SW and OTM were 25, 33, and 21, respectively. Assault was primary intent, GSW (81.8%, n=54) and SW (65.8%, n=158). Patients suffering GSWs had severer injuries, worse admission GCS-M and higher intubation rate at the injury site. Most GSW patients underwent major surgery (59.1%) as an initial procedure and more likely had intracranial haemorrhage (ICH) (21.2%). The 30-day mortality: 45.5% (n=30) for GSWs, 5.4% (n=13) for SWs and 0% (n=0) for OTMs. There was a yearly increase in incidence and mortality for GSW and SW. CONCLUSION: Between 2011 and 2019, there was an increasing yearly trend of incidence and mortality from penetrating HN trauma in Stockholm, Sweden. GSW patients suffered more severe injuries, ICHs, and underwent more surgical interventions compared to SW and OTM.

BACKGROUND: Penetrating trauma to the head and neck (HN) has increased during the past decade in Sweden. This aim of this study was to characterize these injuries and to evaluate the outcome in patients treated at a tertiary trauma centre. METHODS: Swedish trauma registry (SweTrau) data was extracted on patients with HN injuries admitted to Karolinska University Hospital, Stockholm, between 2011 and 2019. Outcome information was extracted from hospital records, with primary endpoints focusing of physiological outcome measures and secondary endpoints on surgical and radiological outcomes. RESULTS: Of 1436 penetrating trauma patients, 329 patients with penetrating HN injuries were identified. 20% (n=66) suffered a gunshot wound (GSW), 73% (n=240) a stab wound (SW), and 7% (n=23) other trauma mechanisms (OTM). The median age for GSW, SW and OTM were 25, 33, and 21, respectively. Assault was primary intent, GSW (81.8%, n=54) and SW (65.8%, n=158). Patients suffering GSWs had severer injuries, worse admission GCS-M and higher intubation rate at the injury site. Most GSW patients underwent major surgery (59.1%) as an initial procedure and more likely had intracranial haemorrhage (ICH) (21.2%). The 30-day mortality: 45.5% (n=30) for GSWs, 5.4% (n=13) for SWs and 0% (n=0) for OTMs. There was a yearly increase in incidence and mortality for GSW and SW. CONCLUSION: Between 2011 and 2019, there was an increasing yearly trend of incidence and mortality from penetrating HN trauma in Stockholm, Sweden. GSW patients suffered more severe injuries, ICHs, and underwent more surgical interventions compared to SW and OTM.

Background Penetrating trauma to the head and neck has increased during the past decade in Sweden. The aim of this study was to characterize these injuries and evaluate the outcomes for patients treated at a tertiary trauma center. Methods Swedish trauma registry data were extracted on patients with head and neck injuries admitted to Karolinska University Hospital (Stockholm, Sweden) between 2011 and 2019. Outcome information was extracted from hospital records, with the primary endpoints focusing on the physiological outcome measures and the secondary endpoints on the surgical and radiological outcomes. Results Of 1436 patients with penetrating trauma, 329 with penetrating head and neck injuries were identified. Of the 329 patients, 66 (20%) had suffered a gunshot wound (GSW), 240 (73%) a stab wound (SW), and 23 (7%) an injury from other trauma mechanisms (OTMs). The median age for the corresponding 3 groups of patients was 25, 33, and 21 years, respectively. Assault was the primary intent, with 54 patients experiencing GSWs (81.8%) and 158 SWs (65.8%). Patients with GSWs had more severe injuries, worse admission Glasgow coma scale, motor, scores, and a higher intubation rate at the injury site. Most GSW patients underwent major surgery (59.1%) as the initial procedure and were more likely to have intracranial hemorrhage (21.2%). The 30-day mortality was 45.5% (n = 30) for GSWs, 5.4% (n = 13) for SWs, and 0% (n = 0) for OTMs. There was an annual increase in the incidence and mortality for GSWs and SWs. Conclusions Between 2011 and 2019, an increasing annual trend was found in the incidence and mortality from penetrating head and neck trauma in Stockholm, Sweden. GSW patients experienced more severe injuries and intracranial hemorrhage and underwent more surgical interventions compared with patients with SWs and OTMs.

Sexual and gender-based harassment is a work environment concern, especially in hierarchical and male-dominant organisations such as the police. This scoping review aims to examine the existing literature on such harassment against police employees in Europe to identify the available knowledge and highlight the gaps for future studies. Following the Arksey and O’Malley framework, 16 relevant articles were analysed. Most of the studies were focused on sexual harassment, and gender-based harassment was mostly absent or mixed with other discriminations. The analysis resulted in six main themes: existence of sexual and gender-based harassment; perpetrators; associated factors; consequences; individual response; and impact of organisational policies. The findings demonstrate that such harassment remains prevalent among police employees, emphasising the need for continuous and rigorous supervision, evaluation, and comprehensive revision of policies by police authorities. This study recommends further research to address the identified gaps in this field., Originally included in thesis in manuscript form.

In this theoretical investigation, we analyze light-induced nonlinear spin Hall currents in a gated single-layer 1T ′ -WTe2, flowing transversely to the incident laser polarization direction. Our study encompasses the exploration of the second and third-order rectified spin Hall currents using an effective low-energy Hamiltonian and employing the Kubo’s formalism. We extend our analysis to a wide frequency range spanning both transparent and absorbing regimes, investigating the influence of light frequency below and above the optical band gap. Additionally, we investigate the influence of an out-of-plane gate potential on the system, disrupting inversion symmetry and effectively manipulating both the strength and sign of nonlinear spin Hall responses. We predict a pronounced third-order spin Hall current relative to its second-order counterpart. The predicted nonlinear spin currents show strong anisotropic dependence on the laser polarization angle. The outcomes of our study contribute to a generalized framework for nonlinear response theory within the spin channel will impact the development of emerging field of opto-spintronic., QC 20240308

This study investigates 30 lone actors in Sweden with a register-based design using a group of male lone actors and two reference groups: same-sex siblings and other male violent extremists. We compare lone actors to the reference groups along social background, criminal background, and co-offending relations (1995 –2016), and mental health (1980–2016). Our results show that lone actors are primarily born in Sweden to two Swedish-born parents. They have a high degree of criminality and co-offending, indicating that they are not completely loners in their criminal behaviour. They have higher enrolment in secondary education than the reference groups, but lower enrolment in higher education than other male violent extremists. Additionally, they suffer considerably more from mental disorders compared to the reference groups. An analysis of criminality and in- and outpatient hospitalisation over the life course indicates that lone actors may have had problems in their transition into middle age.

In this theoretical investigation, we analyze light-induced nonlinear spin Hall currents in a gated single-layer 1T′-WTe2, flowing transversely to the incident laser polarization direction. Our study encompasses the exploration of the second and third-order rectified spin Hall currents using an effective low-energy Hamiltonian and employing the Kubo's formalism. We extend our analysis to a wide frequency range spanning both transparent and absorbing regimes, investigating the influence of light frequency below and above the optical band gap. Additionally, we investigate the influence of an out-of-plane gate potential on the system, disrupting inversion symmetry and effectively manipulating both the strength and sign of nonlinear spin Hall responses. We predict a pronounced third-order spin Hall current relative to its second-order counterpart. The predicted nonlinear spin currents show strong anisotropic dependence on the laser polarization angle. The outcomes of our study contribute to a generalized framework for nonlinear response theory within the spin channel will impact the development of emerging field of opto-spintronic.

This study investigates 30 lone actors in Sweden with a register-based design using a group of male lone actors and two reference groups: same-sex siblings and other male violent extremists. We compare lone actors to the reference groups along social background, criminal background, and co-offending relations (1995 –2016), and mental health (1980–2016). Our results show that lone actors are primarily born in Sweden to two Swedish-born parents. They have a high degree of criminality and co-offending, indicating that they are not completely loners in their criminal behaviour. They have higher enrolment in secondary education than the reference groups, but lower enrolment in higher education than other male violent extremists. Additionally, they suffer considerably more from mental disorders compared to the reference groups. An analysis of criminality and in- and outpatient hospitalisation over the life course indicates that lone actors may have had problems in their transition into middle age.

We investigate the wetting properties of PDMS (Polydimethylsiloxane) pseudo-brush anchored on glass substrates. These PDMS pseudobrushes exhibit a significantly lower contact angle hysteresis compared to hydrophobic silanized substrates. The effect of different molar masses of the used PDMS on the wetting properties seems negligible. The surface roughness and thickness of the PDMS pseudo-brush are measured by atomic force microscopy and x-ray reflectivity. The outcome shows that these surfaces are extremely smooth (topologically and chemically), which explains the reduction in contact angle hysteresis. These special features make this kind of surfaces very useful for wetting experiments. Here, the dynamics of the four-phase contact point are studied on these surfaces. The four-phase contact point dynamics on PDMS pseudo-brushes deviate substantially from its dynamics on other substrates. These changes depend only a little on the molar mass of the used PDMS. In general, PDMS pseudo-brushes increase the traveling speed of four-phase contact point on the surface and change the associated power law of position vs time.

With the evolving role of Model Integrated Evidence (MIE) in generic drug development and regulatory applications, the need for improving Model Sharing, Acceptance, and Communication with the FDA is warranted. Model Master File (MMF) refers to a quantitative model or a modeling platform that has undergone sufficient model Verification & Validation to be recognized as sharable intellectual property that is acceptable for regulatory purposes. MMF provides a framework for regulatorily acceptable modeling practice, which can be used with confidence to support MIE by both the industry and the U.S. Food and Drug Administration (FDA). In 2022, the FDA and the Center for Research on Complex Generics (CRCG) hosted a virtual public workshop to discuss the best practices for utilizing modeling approaches to support generic product development. This report summarizes the presentations and panel discussions of the workshop symposium entitled "Model Sharing, Acceptance, and Communication with the FDA". The symposium and this report serve as a kick-off discussion for further utilities of MMF and best practices of utilizing MMF in drug development and regulatory submissions. The potential advantages of MMFs have garnered acknowledgment from model developers, industries, and the FDA throughout the workshop. To foster a unified comprehension of MMFs and establish best practices for their application, further dialogue and cooperation among stakeholders are imperative. To this end, a subsequent workshop is scheduled for May 2-3, 2024, in Rockville, Maryland, aiming to delve into the practical facets and best practices of MMFs pertinent to regulatory submissions involving modeling and simulation methodologies.

This letter studies the performance of reconfigurable intelligent surface (RIS)-aided communications for a fluid antenna system (FAS) enabled receiver. Specifically, a fixed single-antenna base station (BS) transmits information through a RIS to a mobile user which is equipped with a planar fluid antenna in the absence of a direct link. We first analyze the spatial correlation structures among the positions (or ports) in the planar FAS, and then derive the joint distribution of the equivalent channel gain at the user by exploiting the central limit theorem. Furthermore, we obtain compact analytical expressions for the outage probability (OP) and delay outage rate (DOR). Numerical results illustrate that using FAS with only one activated port into the RIS-aided communication network can greatly enhance the performance, when compared to traditional antenna systems (TAS). IEEE

Nanocellulose has emerged as a widely utilized building block in nanostructured materials due to its availability, sustainability, large surface area, and high stiffness and aspect ratio. The wet or dry elastoplastic properties of these materials are determined by the fibrils' stiffness, chemical properties, hemicellulose content, and the number of fibril contacts. However, the specific contributions and relative importance of each factor remain unclear. Therefore, this work was devoted to systematically comparing the material properties of gels, aerogels, and wet and dry sheets prepared from CNFs with different aspect ratios, chemical functionality, and hemicellulose content. The fibrils were prepared by chemical and mechanical processing of different pulps. By preserving the native structure as much as possible, higher aspect ratio fibrils can be obtained, which allows for the development of more mechanically robust materials. The results demonstrate that higher aspect ratios lead to more interconnected networks at a lower solids concentration, resulting in a more evenly distributed stress and longer-range stress transfer, yielding stiffer and more ductile materials. The most important finding was that the aspect ratio influences the network formation, resulting in different network topologies. The results were also compared to earlier published data and integrated into a theoretical beam-bending model for a complete elastoplastic description of the network properties, including the influence of fibril aspect ratio and chemical functionality. This information improves our understanding and description of nanofibril networks for which general models have been missing. It can be used to optimize nanofibril preparation and, hence, the resulting eco-friendly materials.

Nanocellulose has emerged as a widely utilized building block in nanostructured materials due to its availability, sustainability, large surface area, and high stiffness and aspect ratio. The wet or dry elastoplastic properties of these materials are determined by the fibrils' stiffness, chemical properties, hemicellulose content, and the number of fibril contacts. However, the specific contributions and relative importance of each factor remain unclear. Therefore, this work was devoted to systematically comparing the material properties of gels, aerogels, and wet and dry sheets prepared from CNFs with different aspect ratios, chemical functionality, and hemicellulose content. The fibrils were prepared by chemical and mechanical processing of different pulps. By preserving the native structure as much as possible, higher aspect ratio fibrils can be obtained, which allows for the development of more mechanically robust materials. The results demonstrate that higher aspect ratios lead to more interconnected networks at a lower solids concentration, resulting in a more evenly distributed stress and longer-range stress transfer, yielding stiffer and more ductile materials. The most important finding was that the aspect ratio influences the network formation, resulting in different network topologies. The results were also compared to earlier published data and integrated into a theoretical beam-bending model for a complete elastoplastic description of the network properties, including the influence of fibril aspect ratio and chemical functionality. This information improves our understanding and description of nanofibril networks for which general models have been missing. It can be used to optimize nanofibril preparation and, hence, the resulting eco-friendly materials.

Research in the field of traumatic brain injury has until now heavily relied on the use of animal models to identify potential therapeutic approaches. However, a long series of failed clinical trials has brought many scientists to question the translational reliability of pre-clinical results obtained in animals. The search for an alternative to conventional models that better replicate human pathology in traumatic brain injury is thus of the utmost importance for the field. Recently, orthotopic xenotransplantation of human brain organoids into living animal models has been achieved. This review summarizes the existing literature on this new method, focusing on its potential applications in preclinical research, both in the context of cell replacement therapy and disease modelling. Given the obvious advantages of this approach to study human pathologies in an in vivo context, we here critically review its current limitations while considering its possible applications in traumatic brain injury research.

Nanocellulose has emerged as a widely utilized building block in nanostructured materials due to its availability, sustainability, large surface area, and high stiffness and aspect ratio. The wet or dry elastoplastic properties of these materials are determined by the fibrils' stiffness, chemical properties, hemicellulose content, and the number of fibril contacts. However, the specific contributions and relative importance of each factor remain unclear. Therefore, this work was devoted to systematically comparing the material properties of gels, aerogels, and wet and dry sheets prepared from CNFs with different aspect ratios, chemical functionality, and hemicellulose content. The fibrils were prepared by chemical and mechanical processing of different pulps. By preserving the native structure as much as possible, higher aspect ratio fibrils can be obtained, which allows for the development of more mechanically robust materials. The results demonstrate that higher aspect ratios lead to more interconnected networks at a lower solids concentration, resulting in a more evenly distributed stress and longer-range stress transfer, yielding stiffer and more ductile materials. The most important finding was that the aspect ratio influences the network formation, resulting in different network topologies. The results were also compared to earlier published data and integrated into a theoretical beam-bending model for a complete elastoplastic description of the network properties, including the influence of fibril aspect ratio and chemical functionality. This information improves our understanding and description of nanofibril networks for which general models have been missing. It can be used to optimize nanofibril preparation and, hence, the resulting eco-friendly materials.

This study studies the challenges of effective communication and collaboration in remote design review meetings (DRMs) and explores the potential of Extended Reality (XR) technologies to address these challenges. The research focuses on identifying recurring communication issues and the preferences of companies within the context of remote DRMs. The study involves qualitative content analysis and industry workshops to uncover the current problems with conventional approaches and the aspirations of companies regarding improved collaboration in the DRM process. Drawing upon the insights gathered from both the workshop and design review observations, this paper highlights the features that are critical for collaborative software to handle online design reviews. XR technologies offer immersive and interactive experiences that can transform communication and collaboration in the context of DRMs. By identifying the specific challenges faced in remote DRMs and understanding the desires of companies, this study sets the stage for a more efficient and effective collaborative process. It emphasizes the adaptability of XR technologies to meet industry needs and integrate seamlessly into existing workflows. The study concludes by highlighting the potential for XR technologies to enhance collaboration in DRMs, making them a valuable tool for various industries., The authors would like to thank the Swedish innovation agency Vinnova for their funding of the PLENUM project, grant number: 2022-01704 as well as the partners in the projects that made this work possible.

This study studies the challenges of effective communication and collaboration in remote design review meetings (DRMs) and explores the potential of Extended Reality (XR) technologies to address these challenges. The research focuses on identifying recurring communication issues and the preferences of companies within the context of remote DRMs. The study involves qualitative content analysis and industry workshops to uncover the current problems with conventional approaches and the aspirations of companies regarding improved collaboration in the DRM process. Drawing upon the insights gathered from both the workshop and design review observations, this paper highlights the features that are critical for collaborative software to handle online design reviews. XR technologies offer immersive and interactive experiences that can transform communication and collaboration in the context of DRMs. By identifying the specific challenges faced in remote DRMs and understanding the desires of companies, this study sets the stage for a more efficient and effective collaborative process. It emphasizes the adaptability of XR technologies to meet industry needs and integrate seamlessly into existing workflows. The study concludes by highlighting the potential for XR technologies to enhance collaboration in DRMs, making them a valuable tool for various industries., CC BY-NC 4.0 DEED© 2024 The Authors.Correspondence Address: G.R. Francisco; University of Skövde, Sweden; email: francisco.garcia.rivera@his.seThe authors would like to thank the Swedish innovation agency Vinnova for their funding of the PLENUM project, grant number: 2022-01704 as well as the partners in the projects that made this work possible., PLENUM

Highly anisotropic cellulose nanofibrils can solidify liquid water, creating self-supporting structures by incorporating a tiny number of fibrils. These fibrillar hydrogels can contain as much as 99.99 wt% water. The structure and mechanical properties of fibrillar networks have so far not been completely understood, nor how they solidify the bulk water at such low particle concentrations. In this work, the mechanical properties of cellulose fibrillar hydrogels in the dilute regime from a wt% perspective have been studied, and an elastoplastic model describing the network structure and its mechanics is presented. A significant insight from this work is that the ability of the fibrils to solidify water is very dependent on particle stiffness and the number of contact points it can form in the network structure. The comparison between the experimental results and the theoretical model shows that the fibrillar networks in the dilute regime form via a non-stochastic process since the fibrils have the time and freedom to find contact points during network formation by translational and rotational diffusion. The formed, dilute fibrillar network deforms by sliding fibril contacts upon straining the network beyond its elastic limit. Our results also show that before macroscopic failure, the fibril contacts are restored once the load is released. The exceptional properties of this solidified water are exploited to host fluidic channels, allowing directed fluid transportation in water. Finally, the microfluidic channels formed in the hydrogels are tailored by the layer-by-layer technique to be interactive against external stimuli, a characteristic envisioned to be useful in biomedical applications.

Introduction: Increased levels of extracellular vesicles (EVs) are associated with haemostatic disturbances in various clinical settings. However, their role in COVID-19 patients is still not fully clear. In the present study we investigated EVs in plasma from patients with COVID-19 and neurological symptoms in relation to the activation of coagulation. Methods: Nineteen COVID-19 patients with neurological symptoms and twenty-three aged-matched healthy individuals were included. Global coagulation assays were performed and levels of EVs were determined by flow-cytometry in plasma and cerebrospinal fluid (CSF). Results: A procoagulant state characterized by significantly increased overall coagulation- (OCP) and overall haemostatic potential (OHP), diminished overall fibrinolytic potential (OFP) together with a denser fibrin structure was found in patients with COVID-19. Flow cytometry revealed elevated levels of plasma circulating EVs derived from neutrophils (MPO+) and platelets (CD61+), as well as EVs expressing phosphatidylserine (PS+) and complement component C5b-9 (TCC+) in patients with COVID-19 compared with controls. The concentrations of PS+, CD61+ and TCC+ EVs were positively correlated with OCP and OHP in COVID-19 patients. Moreover, we identified CD61+, MPO+ and endothelial cell-derived EVs, as well as EVs exposing PS and TCC in the CSF of patients suffering from neurological symptoms during COVID-19. Conclusion: The unique finding in this study was the presence of EVs in the CSF of COVID-19 patients with neurologic manifestations as well as higher expression of complement protein on circulating plasma EVs. EVs may indicate blood-brain barrier damage during SARS-COV-2 infection.

Background: The early management of polytrauma patients with traumatic spinal cord injury (tSCI) is a major challenge. Sparse data is available to provide optimal care in this scenario and worldwide variability in clinical practice has been documented in recent studies. Methods: A multidisciplinary consensus panel of physicians selected for their established clinical and scientific expertise in the acute management of tSCI polytrauma patients with different specializations was established. The World Society of Emergency Surgery (WSES) and the European Association of Neurosurgical Societies (EANS) endorsed the consensus, and a modified Delphi approach was adopted. Results: A total of 17 statements were proposed and discussed. A consensus was reached generating 17 recommendations (16 strong and 1 weak). Conclusions: This consensus provides practical recommendations to support a clinician's decision making in the management of tSCI polytrauma patients.

Cellulose-based aerogels are emerging bio-based materials for a range of applications in the quest toward a circular and carbon-neutral society. Owing to their lightweight nature, high porosity, high specific surface area, biocompatibility, and biodegradability, cellulose aerogels are suitable for packaging, insulation, wound care products, hygiene products, and water purification. However, their commercial use is hampered by complicated time- and energy-consuming fabrication processes. Hence, industrially relevant processes with upscaling opportunities need to be developed for cellulose-based aerogels to reach their full potential. This thesis explores different scalable and simple methods for preparing and designing highly porous aerogels with high wet integrity using cellulose-rich fibers and cellulose nanofibrils (CNFs). As wet integrity is crucial for specific applications and enables further functionalization of the aerogels using water-based chemistry, different methods were developed to achieve wet integrity without complicated crosslinking procedures. The effects of the raw materials and processing methods on the final material properties were also carefully studied to optimize the performance for the targeted applications. Moreover, the role of the network-forming ability of CNFs in the development of functional materials with structural integrity was explored by incorporating small amounts of CNFs in aerogel systems based on macroscopic cellulose-rich fibers and nanosized metal-organic frameworks. Finally, the potential of the different developed cellulose-based or cellulose-reinforced aerogels with high wet integrity was demonstrated in applications for which the aerogels’ structural integrity and physical and mechanical properties are highly advantageous, such as biomedical applications, gas storage and separation, flame retardancy, and hygiene products. As demonstrated in this thesis, these functional aerogel materials could be a bio-based alternativ, Cellulosabaserade aerogeler har på senare tid visat sig vara användbara biobaserade material för olika tillämpningar i strävan mot ett cirkulärt och kolneutralt samhälle. Materialens mycket låga densitet, höga porositet, höga specifika yta, biokompatibilitet och biologiska nedbrytbarhet innebär att cellulosaaerogeler är lämpliga för förpackningar, isolering, sårvårdsprodukter, hygienprodukter och vattenrening. Den kommersiella användningen har dock bromsats av komplicerade, tid- och energikrävande tillverkningsmetoder. Därmed måste industriellt relevanta processer med uppskalningsmöjligheter utvecklas för att cellulosabaserade aerogeler ska nå sin fulla potential. Denna avhandling utforskar olika skalbara och enkla metoder för att bereda och skräddarsy högporösa och våtstabila aerogeler från cellulosafibrer och cellulosananofibriller (CNFer). Eftersom våtstabilitet är avgörande för vissa tillämpningar och möjliggör ytterligare funktionalisering med vattenbaserad kemi, har ett omfattande arbete genomförts för att identifiera nya metoder för att skapa en god våtstabilitet utan att använda komplicerade tvärbindningsprocedurer. Ett stort fokus har även lagts på att klarlägga råvarans och bearbetningsmetodernas inverkan på de slutliga materialegenskaperna för att optimera prestandan för riktade tillämpningar. Dessutom har CNFers unika nätverksbildande egenskaper också utforskats i att skapa funktionella material med strukturell integritet från mycket små mängder CNFer i aerogelsystem baserade på makroskopiska cellulosarika fibrer och nanopartiklar av metallorganiska nätverk. Slutligen demonstrerades potentialen av de framställda cellulosabaserade och cellulosaförstärkta aerogelerna med utmärkt våtstyrka i tillämpningar där deras strukturella integritet, fysikaliska och mekaniska egenskaper kan användas på ett mycket fördelaktigt sätt, till exempel biomedicinska applikationer, gaslagring och -separering, flamskydd, och hygienprodukter. Mot bakgrund av dessa resultat är d, QC 20240522Embargo godkänt av skolchef Amelie Eriksson Karlström via e-post 2024-05-14

Generating a pure spin current using electrons, which have degrees of freedom beyond spin, such as electric charge and valley index, presents challenges. In response, we propose a mechanism based on intervalley exciton dynamics in arc-shaped strained transition metal dichalcogenides (TMDs) to achieve the exciton spin Hall effect in an electrically insulating regime, without the need for an external electric field. The interplay between strain gradients and strain-induced pseudomagnetic fields results in a net Lorentz force on long-lived intervalley excitons in WSe2, carrying nonzero spin angular momentum. This process generates an exciton-mediated pure spin Hall current, resulting in opposite-sign spin accumulations and local magnetization on the two sides of the single-layer arc-shaped TMD. We demonstrate that the magnetic field induced by spin accumulation, at approximately ∼mT, can be detected using techniques such as superconducting quantum interference magnetometry or spatially resolved magneto-optical Faraday and Kerr rotations., QC 20240618

Highly anisotropic cellulose nanofibrils can solidify liquid water, creating self-supporting structures by incorporating a tiny number of fibrils. These fibrillar hydrogels can contain as much as 99.99 wt% water. The structure and mechanical properties of fibrillar networks have so far not been completely understood, nor how they solidify the bulk water at such low particle concentrations. In this work, the mechanical properties of cellulose fibrillar hydrogels in the dilute regime from a wt% perspective have been studied, and an elastoplastic model describing the network structure and its mechanics is presented. A significant insight from this work is that the ability of the fibrils to solidify water is very dependent on particle stiffness and the number of contact points it can form in the network structure. The comparison between the experimental results and the theoretical model shows that the fibrillar networks in the dilute regime form via a non-stochastic process since the fibrils have the time and freedom to find contact points during network formation by translational and rotational diffusion. The formed, dilute fibrillar network deforms by sliding fibril contacts upon straining the network beyond its elastic limit. Our results also show that before macroscopic failure, the fibril contacts are restored once the load is released. The exceptional properties of this solidified water are exploited to host fluidic channels, allowing directed fluid transportation in water. Finally, the microfluidic channels formed in the hydrogels are tailored by the layer-by-layer technique to be interactive against external stimuli, a characteristic envisioned to be useful in biomedical applications., QC 20240424

Research in the field of traumatic brain injury has until now heavily relied on the use of animal models to identify potential therapeutic approaches. However, a long series of failed clinical trials has brought many scientists to question the translational reliability of pre-clinical results obtained in animals. The search for an alternative to conventional models that better replicate human pathology in traumatic brain injury is thus of the utmost importance for the field. Recently, orthotopic xenotransplantation of human brain organoids into living animal models has been achieved. This review summarizes the existing literature on this new method, focusing on its potential applications in preclinical research, both in the context of cell replacement therapy and disease modelling. Given the obvious advantages of this approach to study human pathologies in an in vivo context, we here critically review its current limitations while considering its possible applications in traumatic brain injury research.

Introduction: Increased levels of extracellular vesicles (EVs) are associated with haemostatic disturbances in various clinical settings. However, their role in COVID-19 patients is still not fully clear. In the present study we investigated EVs in plasma from patients with COVID-19 and neurological symptoms in relation to the activation of coagulation. Methods: Nineteen COVID-19 patients with neurological symptoms and twenty-three aged-matched healthy individuals were included. Global coagulation assays were performed and levels of EVs were determined by flow-cytometry in plasma and cerebrospinal fluid (CSF). Results: A procoagulant state characterized by significantly increased overall coagulation- (OCP) and overall haemostatic potential (OHP), diminished overall fibrinolytic potential (OFP) together with a denser fibrin structure was found in patients with COVID-19. Flow cytometry revealed elevated levels of plasma circulating EVs derived from neutrophils (MPO+) and platelets (CD61+), as well as EVs expressing phosphatidylserine (PS+) and complement component C5b-9 (TCC+) in patients with COVID-19 compared with controls. The concentrations of PS+, CD61+ and TCC+ EVs were positively correlated with OCP and OHP in COVID-19 patients. Moreover, we identified CD61+, MPO+ and endothelial cell-derived EVs, as well as EVs exposing PS and TCC in the CSF of patients suffering from neurological symptoms during COVID-19. Conclusion: The unique finding in this study was the presence of EVs in the CSF of COVID-19 patients with neurologic manifestations as well as higher expression of complement protein on circulating plasma EVs. EVs may indicate blood-brain barrier damage during SARS-COV-2 infection.

Background: The early management of polytrauma patients with traumatic spinal cord injury (tSCI) is a major challenge. Sparse data is available to provide optimal care in this scenario and worldwide variability in clinical practice has been documented in recent studies. Methods: A multidisciplinary consensus panel of physicians selected for their established clinical and scientific expertise in the acute management of tSCI polytrauma patients with different specializations was established. The World Society of Emergency Surgery (WSES) and the European Association of Neurosurgical Societies (EANS) endorsed the consensus, and a modified Delphi approach was adopted. Results: A total of 17 statements were proposed and discussed. A consensus was reached generating 17 recommendations (16 strong and 1 weak). Conclusions: This consensus provides practical recommendations to support a clinician's decision making in the management of tSCI polytrauma patients.

While there is a substantial research literature on Western ‘foreign fighters’ – those young men and women from Europe, North America, Australia and elsewhere who traveled to Syria and Iraq, from around 2011–2017, to join jihadist groups engaged in combat – there is a dearth of comparative studies examining the backgrounds of these fighters. National variations in the levels of recruitment have been measured and samples examined to determine the demographics of these fighters, indicating some national variations in who went, how, and maybe why. More fulsome comparative data is needed, however, to detect and measure such differences to gain insight into the factors conditioning the radicalization of these foreign fighters. Calling on original and unique datasets, this study presents the results of a comparative analysis of Canadian and Swedish foreign fighters. In each case the findings are compared with other domestic jihadists as well to delineate if those drawn to fight in Syria and Iraq differ. Clear differences emerge in the basic demographics of these national samples, highlighting some empirical and interpretive issues in need of further analysis.

Research in the field of traumatic brain injury has until now heavily relied on the use of animal models to identify potential therapeutic approaches. However, a long series of failed clinical trials has brought many scientists to question the translational reliability of pre-clinical results obtained in animals. The search for an alternative to conventional models that better replicate human pathology in traumatic brain injury is thus of the utmost importance for the field. Recently, orthotopic xenotransplantation of human brain organoids into living animal models has been achieved. This review summarizes the existing literature on this new method, focusing on its potential applications in preclinical research, both in the context of cell replacement therapy and disease modelling. Given the obvious advantages of this approach to study human pathologies in an in vivo context, we here critically review its current limitations while considering its possible applications in traumatic brain injury research.

This study studies the challenges of effective communication and collaboration in remote design review meetings (DRMs) and explores the potential of Extended Reality (XR) technologies to address these challenges. The research focuses on identifying recurring communication issues and the preferences of companies within the context of remote DRMs. The study involves qualitative content analysis and industry workshops to uncover the current problems with conventional approaches and the aspirations of companies regarding improved collaboration in the DRM process. Drawing upon the insights gathered from both the workshop and design review observations, this paper highlights the features that are critical for collaborative software to handle online design reviews. XR technologies offer immersive and interactive experiences that can transform communication and collaboration in the context of DRMs. By identifying the specific challenges faced in remote DRMs and understanding the desires of companies, this study sets the stage for a more efficient and effective collaborative process. It emphasizes the adaptability of XR technologies to meet industry needs and integrate seamlessly into existing workflows. The study concludes by highlighting the potential for XR technologies to enhance collaboration in DRMs, making them a valuable tool for various industries., The authors would like to thank the Swedish innovation agency Vinnova for their funding of the PLENUM project, grant number: 2022-01704 as well as the partners in the projects that made this work possible.

Highly anisotropic cellulose nanofibrils can solidify liquid water, creating self-supporting structures by incorporating a tiny number of fibrils. These fibrillar hydrogels can contain as much as 99.99 wt% water. The structure and mechanical properties of fibrillar networks have so far not been completely understood, nor how they solidify the bulk water at such low particle concentrations. In this work, the mechanical properties of cellulose fibrillar hydrogels in the dilute regime from a wt% perspective have been studied, and an elastoplastic model describing the network structure and its mechanics is presented. A significant insight from this work is that the ability of the fibrils to solidify water is very dependent on particle stiffness and the number of contact points it can form in the network structure. The comparison between the experimental results and the theoretical model shows that the fibrillar networks in the dilute regime form via a non-stochastic process since the fibrils have the time and freedom to find contact points during network formation by translational and rotational diffusion. The formed, dilute fibrillar network deforms by sliding fibril contacts upon straining the network beyond its elastic limit. Our results also show that before macroscopic failure, the fibril contacts are restored once the load is released. The exceptional properties of this solidified water are exploited to host fluidic channels, allowing directed fluid transportation in water. Finally, the microfluidic channels formed in the hydrogels are tailored by the layer-by-layer technique to be interactive against external stimuli, a characteristic envisioned to be useful in biomedical applications.

Introduction: Increased levels of extracellular vesicles (EVs) are associated with haemostatic disturbances in various clinical settings. However, their role in COVID-19 patients is still not fully clear. In the present study we investigated EVs in plasma from patients with COVID-19 and neurological symptoms in relation to the activation of coagulation. Methods: Nineteen COVID-19 patients with neurological symptoms and twenty-three aged-matched healthy individuals were included. Global coagulation assays were performed and levels of EVs were determined by flow-cytometry in plasma and cerebrospinal fluid (CSF). Results: A procoagulant state characterized by significantly increased overall coagulation- (OCP) and overall haemostatic potential (OHP), diminished overall fibrinolytic potential (OFP) together with a denser fibrin structure was found in patients with COVID-19. Flow cytometry revealed elevated levels of plasma circulating EVs derived from neutrophils (MPO+) and platelets (CD61+), as well as EVs expressing phosphatidylserine (PS+) and complement component C5b-9 (TCC+) in patients with COVID-19 compared with controls. The concentrations of PS+, CD61+ and TCC+ EVs were positively correlated with OCP and OHP in COVID-19 patients. Moreover, we identified CD61+, MPO+ and endothelial cell-derived EVs, as well as EVs exposing PS and TCC in the CSF of patients suffering from neurological symptoms during COVID-19. Conclusion: The unique finding in this study was the presence of EVs in the CSF of COVID-19 patients with neurologic manifestations as well as higher expression of complement protein on circulating plasma EVs. EVs may indicate blood-brain barrier damage during SARS-COV-2 infection.

Background: The early management of polytrauma patients with traumatic spinal cord injury (tSCI) is a major challenge. Sparse data is available to provide optimal care in this scenario and worldwide variability in clinical practice has been documented in recent studies. Methods: A multidisciplinary consensus panel of physicians selected for their established clinical and scientific expertise in the acute management of tSCI polytrauma patients with different specializations was established. The World Society of Emergency Surgery (WSES) and the European Association of Neurosurgical Societies (EANS) endorsed the consensus, and a modified Delphi approach was adopted. Results: A total of 17 statements were proposed and discussed. A consensus was reached generating 17 recommendations (16 strong and 1 weak). Conclusions: This consensus provides practical recommendations to support a clinician's decision making in the management of tSCI polytrauma patients.

Research in the field of traumatic brain injury has until now heavily relied on the use of animal models to identify potential therapeutic approaches. However, a long series of failed clinical trials has brought many scientists to question the translational reliability of pre-clinical results obtained in animals. The search for an alternative to conventional models that better replicate human pathology in traumatic brain injury is thus of the utmost importance for the field. Recently, orthotopic xenotransplantation of human brain organoids into living animal models has been achieved. This review summarizes the existing literature on this new method, focusing on its potential applications in preclinical research, both in the context of cell replacement therapy and disease modelling. Given the obvious advantages of this approach to study human pathologies in an in vivo context, we here critically review its current limitations while considering its possible applications in traumatic brain injury research.

Objective:The majority of traumatic brain injuries (TBIs) are classified as mild and occur in young individuals. The course of recovery varies but can result in chronic or troubling outcomes. The impact of age on TBI outcomes in young adults before complete brain maturation is not well studied.Methods:In this study, we compared the effects of mild TBI on cognitive performance and self-reported TBI symptoms and posttraumatic stress disorder (PTSD) in 903 soldiers in 3 different age groups: 24 years or younger, 25 to 27 years, and 28 to 40 years. The soldiers had returned from war zones in Iraq and were screened for TBI within a few days of return. Cognitive performance was measured with the Automated Neuropsychological Assessment Metrics of Military TBI Version 4 (ANAM4). Symptoms associated with mild TBI were self-reported on the Neurobehavioral Symptom Inventory, and the PTSD Checklist-Civilian Version (PCL-C).Results:Soldiers with TBI in every age group had significantly higher prevalence of most symptoms than those with no TBI. Soldiers with TBI also reported more chronic pain sites, regardless of age. Soldiers aged 28 to 40 years with TBI had the lowest cognitive performance scores (ANAM) across several subtests, both unadjusted and adjusted. The Global Deficit Score was significantly higher for soldiers aged 28 to 40 years and 25 to 27 years with TBI than for soldiers younger than 24 years with no TBI. After adjusting for PTSD symptoms, education, and number of lifetime TBIs, the overall test battery mean for soldiers aged 28 to 40 years with TBI was significantly lower than for soldiers younger than 24 years with no TBI.Conclusion:Soldiers with mild TBI in the younger age group show more symptoms associated to frontal lobe function while soldiers in the older group suffer more cognitive impairment. This may warrant further study as it may indicate a propensity to later cognitive decline among soldiers who were older at the time of injury.

Introduction: Increased levels of extracellular vesicles (EVs) are associated with haemostatic disturbances in various clinical settings. However, their role in COVID-19 patients is still not fully clear. In the present study we investigated EVs in plasma from patients with COVID-19 and neurological symptoms in relation to the activation of coagulation. Methods: Nineteen COVID-19 patients with neurological symptoms and twenty-three aged-matched healthy individuals were included. Global coagulation assays were performed and levels of EVs were determined by flow-cytometry in plasma and cerebrospinal fluid (CSF). Results: A procoagulant state characterized by significantly increased overall coagulation- (OCP) and overall haemostatic potential (OHP), diminished overall fibrinolytic potential (OFP) together with a denser fibrin structure was found in patients with COVID-19. Flow cytometry revealed elevated levels of plasma circulating EVs derived from neutrophils (MPO+) and platelets (CD61+), as well as EVs expressing phosphatidylserine (PS+) and complement component C5b-9 (TCC+) in patients with COVID-19 compared with controls. The concentrations of PS+, CD61+ and TCC+ EVs were positively correlated with OCP and OHP in COVID-19 patients. Moreover, we identified CD61+, MPO+ and endothelial cell-derived EVs, as well as EVs exposing PS and TCC in the CSF of patients suffering from neurological symptoms during COVID-19. Conclusion: The unique finding in this study was the presence of EVs in the CSF of COVID-19 patients with neurologic manifestations as well as higher expression of complement protein on circulating plasma EVs. EVs may indicate blood-brain barrier damage during SARS-COV-2 infection.