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18 results on '"Ronkainen, Antti"'

1. Varieties of central banking : the Nordic Model beyond a fiscal-centric approach

Author

Jackson, James, Lindberg, Elisabeth, Ronkainen, Antti, Møller Stahl, Rune, Jackson, James, Lindberg, Elisabeth, Ronkainen, Antti, and Møller Stahl, Rune

Abstract

Since policymakers and scholars coined the term in the 1930s, the Nordic Model has often been considered to denote a homogeneous political entity in which the constituent countries are ostensibly interchangeable. As a result, seldom attention has been afforded to what fundamentally differentiates Denmark, Finland, Norway, and Sweden. By going beyond traditional ‘fiscal-centric’ accounts of the Nordic model, and instead focusing on the role of central banks and monetary policy, we show that each country bares far less similarities than has often been assumed in the literature. We trace this heterogeneity back to variegated responses to the 1970s crises of Fordist capitalism and draw on growth model theory to explain this divergent trajectory. We show how these differences shaped how each country responded to the Global Financial Crisis and the COVID-19 pandemic, where a variegated array of monetary measures was employed to uphold their own distinct growth model. By accounting for the role of central banks within the Nordic Model, we propose that it is better understood as a series of models, drawing attention to the function of monetary policy within the growth models perspective in the political economy literature.

Published
2024
Full Text
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2. Varieties of central banking : the Nordic Model beyond a fiscal-centric approach

Author

Jackson, James, Lindberg, Elisabeth, Ronkainen, Antti, Møller Stahl, Rune, Jackson, James, Lindberg, Elisabeth, Ronkainen, Antti, and Møller Stahl, Rune

Abstract

Since policymakers and scholars coined the term in the 1930s, the Nordic Model has often been considered to denote a homogeneous political entity in which the constituent countries are ostensibly interchangeable. As a result, seldom attention has been afforded to what fundamentally differentiates Denmark, Finland, Norway, and Sweden. By going beyond traditional ‘fiscal-centric’ accounts of the Nordic model, and instead focusing on the role of central banks and monetary policy, we show that each country bares far less similarities than has often been assumed in the literature. We trace this heterogeneity back to variegated responses to the 1970s crises of Fordist capitalism and draw on growth model theory to explain this divergent trajectory. We show how these differences shaped how each country responded to the Global Financial Crisis and the COVID-19 pandemic, where a variegated array of monetary measures was employed to uphold their own distinct growth model. By accounting for the role of central banks within the Nordic Model, we propose that it is better understood as a series of models, drawing attention to the function of monetary policy within the growth models perspective in the political economy literature.

Published
2024
Full Text
View/download PDF

3. Varieties of central banking : the Nordic Model beyond a fiscal-centric approach

Author

Jackson, James, Lindberg, Elisabeth, Ronkainen, Antti, Møller Stahl, Rune, Jackson, James, Lindberg, Elisabeth, Ronkainen, Antti, and Møller Stahl, Rune

Abstract

Since policymakers and scholars coined the term in the 1930s, the Nordic Model has often been considered to denote a homogeneous political entity in which the constituent countries are ostensibly interchangeable. As a result, seldom attention has been afforded to what fundamentally differentiates Denmark, Finland, Norway, and Sweden. By going beyond traditional ‘fiscal-centric’ accounts of the Nordic model, and instead focusing on the role of central banks and monetary policy, we show that each country bares far less similarities than has often been assumed in the literature. We trace this heterogeneity back to variegated responses to the 1970s crises of Fordist capitalism and draw on growth model theory to explain this divergent trajectory. We show how these differences shaped how each country responded to the Global Financial Crisis and the COVID-19 pandemic, where a variegated array of monetary measures was employed to uphold their own distinct growth model. By accounting for the role of central banks within the Nordic Model, we propose that it is better understood as a series of models, drawing attention to the function of monetary policy within the growth models perspective in the political economy literature.

Published
2024
Full Text
View/download PDF

4. Varieties of central banking : the Nordic Model beyond a fiscal-centric approach

Author

Jackson, James, Lindberg, Elisabeth, Ronkainen, Antti, Møller Stahl, Rune, Jackson, James, Lindberg, Elisabeth, Ronkainen, Antti, and Møller Stahl, Rune

Abstract

Since policymakers and scholars coined the term in the 1930s, the Nordic Model has often been considered to denote a homogeneous political entity in which the constituent countries are ostensibly interchangeable. As a result, seldom attention has been afforded to what fundamentally differentiates Denmark, Finland, Norway, and Sweden. By going beyond traditional ‘fiscal-centric’ accounts of the Nordic model, and instead focusing on the role of central banks and monetary policy, we show that each country bares far less similarities than has often been assumed in the literature. We trace this heterogeneity back to variegated responses to the 1970s crises of Fordist capitalism and draw on growth model theory to explain this divergent trajectory. We show how these differences shaped how each country responded to the Global Financial Crisis and the COVID-19 pandemic, where a variegated array of monetary measures was employed to uphold their own distinct growth model. By accounting for the role of central banks within the Nordic Model, we propose that it is better understood as a series of models, drawing attention to the function of monetary policy within the growth models perspective in the political economy literature.

Published
2024
Full Text
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5. External Validation of the ELAPSS Score for Prediction of Unruptured Intracranial Aneurysm Growth Risk

Author

Kammen, Mayte Sánchez van, Greving, Jacoba P, Kuroda, Satoshi, Kashiwazaki, Daina, Morita, Akio, Shiokawa, Yoshiaki, Kimura, Toshikazu, Cognard, Christophe, Januel, Anne C, Lindgren, Antti, Koivisto, Timo, Jääskeläinen, Juha E, Ronkainen, Antti, Pyysalo, Liisa, Öhman, Juha, Rahi, Melissa, Kuhmonen, Johanna, Rinne, Jaakko, Leemans, Eva L, Majoie, Charles B, Vandertop, W Peter, Verbaan, Dagmar, Roos, Yvo B W E M, Berg, René van den, Boogaarts, Hieronymus D, Moudrous, Walid, Wijngaard, Ido R van den, Hove, Laura Ten, Teo, Mario, George, Edward J St, Hackenberg, Katharina A M, Abdulazim, Amr, Etminan, Nima, Rinkel, Gabriël J E, Vergouwen, Mervyn D I, Kammen, Mayte Sánchez van, Greving, Jacoba P, Kuroda, Satoshi, Kashiwazaki, Daina, Morita, Akio, Shiokawa, Yoshiaki, Kimura, Toshikazu, Cognard, Christophe, Januel, Anne C, Lindgren, Antti, Koivisto, Timo, Jääskeläinen, Juha E, Ronkainen, Antti, Pyysalo, Liisa, Öhman, Juha, Rahi, Melissa, Kuhmonen, Johanna, Rinne, Jaakko, Leemans, Eva L, Majoie, Charles B, Vandertop, W Peter, Verbaan, Dagmar, Roos, Yvo B W E M, Berg, René van den, Boogaarts, Hieronymus D, Moudrous, Walid, Wijngaard, Ido R van den, Hove, Laura Ten, Teo, Mario, George, Edward J St, Hackenberg, Katharina A M, Abdulazim, Amr, Etminan, Nima, Rinkel, Gabriël J E, and Vergouwen, Mervyn D I

Published
2019

6. External Validation of the ELAPSS Score for Prediction of Unruptured Intracranial Aneurysm Growth Risk

Author

Kammen, Mayte Sánchez van, Greving, Jacoba P, Kuroda, Satoshi, Kashiwazaki, Daina, Morita, Akio, Shiokawa, Yoshiaki, Kimura, Toshikazu, Cognard, Christophe, Januel, Anne C, Lindgren, Antti, Koivisto, Timo, Jääskeläinen, Juha E, Ronkainen, Antti, Pyysalo, Liisa, Öhman, Juha, Rahi, Melissa, Kuhmonen, Johanna, Rinne, Jaakko, Leemans, Eva L, Majoie, Charles B, Vandertop, W Peter, Verbaan, Dagmar, Roos, Yvo B W E M, Berg, René van den, Boogaarts, Hieronymus D, Moudrous, Walid, Wijngaard, Ido R van den, Hove, Laura Ten, Teo, Mario, George, Edward J St, Hackenberg, Katharina A M, Abdulazim, Amr, Etminan, Nima, Rinkel, Gabriël J E, Vergouwen, Mervyn D I, Kammen, Mayte Sánchez van, Greving, Jacoba P, Kuroda, Satoshi, Kashiwazaki, Daina, Morita, Akio, Shiokawa, Yoshiaki, Kimura, Toshikazu, Cognard, Christophe, Januel, Anne C, Lindgren, Antti, Koivisto, Timo, Jääskeläinen, Juha E, Ronkainen, Antti, Pyysalo, Liisa, Öhman, Juha, Rahi, Melissa, Kuhmonen, Johanna, Rinne, Jaakko, Leemans, Eva L, Majoie, Charles B, Vandertop, W Peter, Verbaan, Dagmar, Roos, Yvo B W E M, Berg, René van den, Boogaarts, Hieronymus D, Moudrous, Walid, Wijngaard, Ido R van den, Hove, Laura Ten, Teo, Mario, George, Edward J St, Hackenberg, Katharina A M, Abdulazim, Amr, Etminan, Nima, Rinkel, Gabriël J E, and Vergouwen, Mervyn D I

Published
2019

7. External Validation of the ELAPSS Score for Prediction of Unruptured Intracranial Aneurysm Growth Risk

Author

Kammen, Mayte Sánchez van, Greving, Jacoba P, Kuroda, Satoshi, Kashiwazaki, Daina, Morita, Akio, Shiokawa, Yoshiaki, Kimura, Toshikazu, Cognard, Christophe, Januel, Anne C, Lindgren, Antti, Koivisto, Timo, Jääskeläinen, Juha E, Ronkainen, Antti, Pyysalo, Liisa, Öhman, Juha, Rahi, Melissa, Kuhmonen, Johanna, Rinne, Jaakko, Leemans, Eva L, Majoie, Charles B, Vandertop, W Peter, Verbaan, Dagmar, Roos, Yvo B W E M, Berg, René van den, Boogaarts, Hieronymus D, Moudrous, Walid, Wijngaard, Ido R van den, Hove, Laura Ten, Teo, Mario, George, Edward J St, Hackenberg, Katharina A M, Abdulazim, Amr, Etminan, Nima, Rinkel, Gabriël J E, Vergouwen, Mervyn D I, Kammen, Mayte Sánchez van, Greving, Jacoba P, Kuroda, Satoshi, Kashiwazaki, Daina, Morita, Akio, Shiokawa, Yoshiaki, Kimura, Toshikazu, Cognard, Christophe, Januel, Anne C, Lindgren, Antti, Koivisto, Timo, Jääskeläinen, Juha E, Ronkainen, Antti, Pyysalo, Liisa, Öhman, Juha, Rahi, Melissa, Kuhmonen, Johanna, Rinne, Jaakko, Leemans, Eva L, Majoie, Charles B, Vandertop, W Peter, Verbaan, Dagmar, Roos, Yvo B W E M, Berg, René van den, Boogaarts, Hieronymus D, Moudrous, Walid, Wijngaard, Ido R van den, Hove, Laura Ten, Teo, Mario, George, Edward J St, Hackenberg, Katharina A M, Abdulazim, Amr, Etminan, Nima, Rinkel, Gabriël J E, and Vergouwen, Mervyn D I

Published
2019

8. External Validation of the ELAPSS Score for Prediction of Unruptured Intracranial Aneurysm Growth Risk

Author

Cardiovasculaire Epi Team 6, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, ZL Cerebrovasculaire Ziekten Medisch, Neurologie, Brain, Kammen, Mayte Sánchez van, Greving, Jacoba P, Kuroda, Satoshi, Kashiwazaki, Daina, Morita, Akio, Shiokawa, Yoshiaki, Kimura, Toshikazu, Cognard, Christophe, Januel, Anne C, Lindgren, Antti, Koivisto, Timo, Jääskeläinen, Juha E, Ronkainen, Antti, Pyysalo, Liisa, Öhman, Juha, Rahi, Melissa, Kuhmonen, Johanna, Rinne, Jaakko, Leemans, Eva L, Majoie, Charles B, Vandertop, W Peter, Verbaan, Dagmar, Roos, Yvo B W E M, Berg, René van den, Boogaarts, Hieronymus D, Moudrous, Walid, Wijngaard, Ido R van den, Hove, Laura Ten, Teo, Mario, George, Edward J St, Hackenberg, Katharina A M, Abdulazim, Amr, Etminan, Nima, Rinkel, Gabriël J E, Vergouwen, Mervyn D I, Cardiovasculaire Epi Team 6, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, ZL Cerebrovasculaire Ziekten Medisch, Neurologie, Brain, Kammen, Mayte Sánchez van, Greving, Jacoba P, Kuroda, Satoshi, Kashiwazaki, Daina, Morita, Akio, Shiokawa, Yoshiaki, Kimura, Toshikazu, Cognard, Christophe, Januel, Anne C, Lindgren, Antti, Koivisto, Timo, Jääskeläinen, Juha E, Ronkainen, Antti, Pyysalo, Liisa, Öhman, Juha, Rahi, Melissa, Kuhmonen, Johanna, Rinne, Jaakko, Leemans, Eva L, Majoie, Charles B, Vandertop, W Peter, Verbaan, Dagmar, Roos, Yvo B W E M, Berg, René van den, Boogaarts, Hieronymus D, Moudrous, Walid, Wijngaard, Ido R van den, Hove, Laura Ten, Teo, Mario, George, Edward J St, Hackenberg, Katharina A M, Abdulazim, Amr, Etminan, Nima, Rinkel, Gabriël J E, and Vergouwen, Mervyn D I

Published
2019

9. The unruptured intracranial aneurysm treatment score : A multidis ciplinary consensus

Author

Etminan, Nima, Brown, Robert D., Beseoglu, Kerim, Juvela, Seppo, Raymond, Jean, Morita, Akio, Torner, James C., Derdeyn, Colin P., Raabe, Andreas, Mocco, J., Korja, Miikka, Abdulazim, Amr, Amin-Hanjani, Sepideh, Salman, Rustam Al Shahi, Barrow, Daniel L., Bederson, Joshua, Bonafe, Alain, Dumont, Aaron S., Fiorella, David J., Gruber, Andreas, Hankey, Graeme J., Hasan, David M., Hoh, Brian L., Jabbour, Pascal, Kasuya, Hidetoshi, Kelly, Michael E., Kirkpatrick, Peter J., Knuckey, Neville, Koivisto, Timo, Krings, Timo, Lawton, Michael T., Marotta, Thomas R., Mayer, Stephan A., Mee, Edward, Pereira, Vitor Mendes, Molyneux, Andrew, Morgan, Michael K., Mori, Kentaro, Murayama, Yuichi, Nagahiro, Shinji, Nakayama, Naoki, Niemelä, Mika, Ogilvy, Christopher S., Pierot, Laurent, Rabinstein, Alejandro A., Roos, Yvo B W E M, Rinne, Jaakko, Rosenwasser, Robert H., Ronkainen, Antti, Schaller, Karl, Seifert, Volker, Solomon, Robert A., Spears, Julian, Steiger, Hans Jakob, Vergouwen, Mervyn D I, Wanke, Isabel, Wermer, Marieke J H, Wong, George K C, Wong, John H., Zipfel, Gregory J., Sander Connolly, E., Steinmetz, Helmuth, Lanzino, Giuseppe, Pasqualin, Alberto, Rüfenacht, Daniel, Vajkoczy, Peter, McDougall, Cameron, Hänggi, Daniel, Leroux, Peter, Rinkel, Gabriel J E, Loch Macdonald, R., Etminan, Nima, Brown, Robert D., Beseoglu, Kerim, Juvela, Seppo, Raymond, Jean, Morita, Akio, Torner, James C., Derdeyn, Colin P., Raabe, Andreas, Mocco, J., Korja, Miikka, Abdulazim, Amr, Amin-Hanjani, Sepideh, Salman, Rustam Al Shahi, Barrow, Daniel L., Bederson, Joshua, Bonafe, Alain, Dumont, Aaron S., Fiorella, David J., Gruber, Andreas, Hankey, Graeme J., Hasan, David M., Hoh, Brian L., Jabbour, Pascal, Kasuya, Hidetoshi, Kelly, Michael E., Kirkpatrick, Peter J., Knuckey, Neville, Koivisto, Timo, Krings, Timo, Lawton, Michael T., Marotta, Thomas R., Mayer, Stephan A., Mee, Edward, Pereira, Vitor Mendes, Molyneux, Andrew, Morgan, Michael K., Mori, Kentaro, Murayama, Yuichi, Nagahiro, Shinji, Nakayama, Naoki, Niemelä, Mika, Ogilvy, Christopher S., Pierot, Laurent, Rabinstein, Alejandro A., Roos, Yvo B W E M, Rinne, Jaakko, Rosenwasser, Robert H., Ronkainen, Antti, Schaller, Karl, Seifert, Volker, Solomon, Robert A., Spears, Julian, Steiger, Hans Jakob, Vergouwen, Mervyn D I, Wanke, Isabel, Wermer, Marieke J H, Wong, George K C, Wong, John H., Zipfel, Gregory J., Sander Connolly, E., Steinmetz, Helmuth, Lanzino, Giuseppe, Pasqualin, Alberto, Rüfenacht, Daniel, Vajkoczy, Peter, McDougall, Cameron, Hänggi, Daniel, Leroux, Peter, Rinkel, Gabriel J E, and Loch Macdonald, R.

Published
2015

10. The unruptured intracranial aneurysm treatment score : A multidis ciplinary consensus

Author

Etminan, Nima, Brown, Robert D., Beseoglu, Kerim, Juvela, Seppo, Raymond, Jean, Morita, Akio, Torner, James C., Derdeyn, Colin P., Raabe, Andreas, Mocco, J., Korja, Miikka, Abdulazim, Amr, Amin-Hanjani, Sepideh, Salman, Rustam Al Shahi, Barrow, Daniel L., Bederson, Joshua, Bonafe, Alain, Dumont, Aaron S., Fiorella, David J., Gruber, Andreas, Hankey, Graeme J., Hasan, David M., Hoh, Brian L., Jabbour, Pascal, Kasuya, Hidetoshi, Kelly, Michael E., Kirkpatrick, Peter J., Knuckey, Neville, Koivisto, Timo, Krings, Timo, Lawton, Michael T., Marotta, Thomas R., Mayer, Stephan A., Mee, Edward, Pereira, Vitor Mendes, Molyneux, Andrew, Morgan, Michael K., Mori, Kentaro, Murayama, Yuichi, Nagahiro, Shinji, Nakayama, Naoki, Niemelä, Mika, Ogilvy, Christopher S., Pierot, Laurent, Rabinstein, Alejandro A., Roos, Yvo B W E M, Rinne, Jaakko, Rosenwasser, Robert H., Ronkainen, Antti, Schaller, Karl, Seifert, Volker, Solomon, Robert A., Spears, Julian, Steiger, Hans Jakob, Vergouwen, Mervyn D I, Wanke, Isabel, Wermer, Marieke J H, Wong, George K C, Wong, John H., Zipfel, Gregory J., Sander Connolly, E., Steinmetz, Helmuth, Lanzino, Giuseppe, Pasqualin, Alberto, Rüfenacht, Daniel, Vajkoczy, Peter, McDougall, Cameron, Hänggi, Daniel, Leroux, Peter, Rinkel, Gabriel J E, Loch Macdonald, R., Etminan, Nima, Brown, Robert D., Beseoglu, Kerim, Juvela, Seppo, Raymond, Jean, Morita, Akio, Torner, James C., Derdeyn, Colin P., Raabe, Andreas, Mocco, J., Korja, Miikka, Abdulazim, Amr, Amin-Hanjani, Sepideh, Salman, Rustam Al Shahi, Barrow, Daniel L., Bederson, Joshua, Bonafe, Alain, Dumont, Aaron S., Fiorella, David J., Gruber, Andreas, Hankey, Graeme J., Hasan, David M., Hoh, Brian L., Jabbour, Pascal, Kasuya, Hidetoshi, Kelly, Michael E., Kirkpatrick, Peter J., Knuckey, Neville, Koivisto, Timo, Krings, Timo, Lawton, Michael T., Marotta, Thomas R., Mayer, Stephan A., Mee, Edward, Pereira, Vitor Mendes, Molyneux, Andrew, Morgan, Michael K., Mori, Kentaro, Murayama, Yuichi, Nagahiro, Shinji, Nakayama, Naoki, Niemelä, Mika, Ogilvy, Christopher S., Pierot, Laurent, Rabinstein, Alejandro A., Roos, Yvo B W E M, Rinne, Jaakko, Rosenwasser, Robert H., Ronkainen, Antti, Schaller, Karl, Seifert, Volker, Solomon, Robert A., Spears, Julian, Steiger, Hans Jakob, Vergouwen, Mervyn D I, Wanke, Isabel, Wermer, Marieke J H, Wong, George K C, Wong, John H., Zipfel, Gregory J., Sander Connolly, E., Steinmetz, Helmuth, Lanzino, Giuseppe, Pasqualin, Alberto, Rüfenacht, Daniel, Vajkoczy, Peter, McDougall, Cameron, Hänggi, Daniel, Leroux, Peter, Rinkel, Gabriel J E, and Loch Macdonald, R.

Published
2015

11. The unruptured intracranial aneurysm treatment score : A multidis ciplinary consensus

Author

Etminan, Nima, Brown, Robert D., Beseoglu, Kerim, Juvela, Seppo, Raymond, Jean, Morita, Akio, Torner, James C., Derdeyn, Colin P., Raabe, Andreas, Mocco, J., Korja, Miikka, Abdulazim, Amr, Amin-Hanjani, Sepideh, Salman, Rustam Al Shahi, Barrow, Daniel L., Bederson, Joshua, Bonafe, Alain, Dumont, Aaron S., Fiorella, David J., Gruber, Andreas, Hankey, Graeme J., Hasan, David M., Hoh, Brian L., Jabbour, Pascal, Kasuya, Hidetoshi, Kelly, Michael E., Kirkpatrick, Peter J., Knuckey, Neville, Koivisto, Timo, Krings, Timo, Lawton, Michael T., Marotta, Thomas R., Mayer, Stephan A., Mee, Edward, Pereira, Vitor Mendes, Molyneux, Andrew, Morgan, Michael K., Mori, Kentaro, Murayama, Yuichi, Nagahiro, Shinji, Nakayama, Naoki, Niemelä, Mika, Ogilvy, Christopher S., Pierot, Laurent, Rabinstein, Alejandro A., Roos, Yvo B W E M, Rinne, Jaakko, Rosenwasser, Robert H., Ronkainen, Antti, Schaller, Karl, Seifert, Volker, Solomon, Robert A., Spears, Julian, Steiger, Hans Jakob, Vergouwen, Mervyn D I, Wanke, Isabel, Wermer, Marieke J H, Wong, George K C, Wong, John H., Zipfel, Gregory J., Sander Connolly, E., Steinmetz, Helmuth, Lanzino, Giuseppe, Pasqualin, Alberto, Rüfenacht, Daniel, Vajkoczy, Peter, McDougall, Cameron, Hänggi, Daniel, Leroux, Peter, Rinkel, Gabriel J E, Loch Macdonald, R., Etminan, Nima, Brown, Robert D., Beseoglu, Kerim, Juvela, Seppo, Raymond, Jean, Morita, Akio, Torner, James C., Derdeyn, Colin P., Raabe, Andreas, Mocco, J., Korja, Miikka, Abdulazim, Amr, Amin-Hanjani, Sepideh, Salman, Rustam Al Shahi, Barrow, Daniel L., Bederson, Joshua, Bonafe, Alain, Dumont, Aaron S., Fiorella, David J., Gruber, Andreas, Hankey, Graeme J., Hasan, David M., Hoh, Brian L., Jabbour, Pascal, Kasuya, Hidetoshi, Kelly, Michael E., Kirkpatrick, Peter J., Knuckey, Neville, Koivisto, Timo, Krings, Timo, Lawton, Michael T., Marotta, Thomas R., Mayer, Stephan A., Mee, Edward, Pereira, Vitor Mendes, Molyneux, Andrew, Morgan, Michael K., Mori, Kentaro, Murayama, Yuichi, Nagahiro, Shinji, Nakayama, Naoki, Niemelä, Mika, Ogilvy, Christopher S., Pierot, Laurent, Rabinstein, Alejandro A., Roos, Yvo B W E M, Rinne, Jaakko, Rosenwasser, Robert H., Ronkainen, Antti, Schaller, Karl, Seifert, Volker, Solomon, Robert A., Spears, Julian, Steiger, Hans Jakob, Vergouwen, Mervyn D I, Wanke, Isabel, Wermer, Marieke J H, Wong, George K C, Wong, John H., Zipfel, Gregory J., Sander Connolly, E., Steinmetz, Helmuth, Lanzino, Giuseppe, Pasqualin, Alberto, Rüfenacht, Daniel, Vajkoczy, Peter, McDougall, Cameron, Hänggi, Daniel, Leroux, Peter, Rinkel, Gabriel J E, and Loch Macdonald, R.

Published
2015

12. Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism

Author

Helgadottir, Anna, Gretarsdottir, Solveig, Thorleifsson, Gudmar, Holm, Hilma, Patel, Riyaz S, Gudnason, Thorarinn, Jones, Gregory T, van Rij, Andre M, Eapen, Danny J, Baas, Annette F, Tregouet, David-Alexandre, Morange, Pierre-Emmanuel, Emmerich, Joseph, Lindblad, Bengt, Gottsäter, Anders, Kiemeny, Lambertus A, Lindholt, Jes S., Sakalihasan, Natzi, Ferrell, Robert E, Carey, David J, Elmore, James R, Tsao, Philip S, Grarup, Niels, Jørgensen, Torben, Witte, Daniel R, Hansen, Torben, Pedersen, Oluf, Pola, Roberto, Gaetani, Eleonora, Magnadottir, Hulda B, Wijmenga, Cisca, Tromp, Gerard, Ronkainen, Antti, Ruigrok, Ynte M, Blankensteijn, Jan D, Mueller, Thomas, Wells, Philip S, Corral, Javier, Soria, Jose Manuel, Souto, Juan Carlos, Peden, John F, Jalilzadeh, Shapour, Mayosi, Bongani M, Keavney, Bernard, Strawbridge, Rona J, Sabater-Lleal, Maria, Gertow, Karl, Baldassarre, Damiano, Nyyssönen, Kristiina, Rauramaa, Rainer, Smit, Andries J, Mannarino, Elmo, Giral, Philippe, Tremoli, Elena, de Faire, Ulf, Humphries, Steve E, Hamsten, Anders, Haraldsdottir, Vilhelmina, Olafsson, Isleifur, Magnusson, Magnus K, Samani, Nilesh J, Levey, Allan I, Markus, Hugh S, Kostulas, Konstantinos, Dichgans, Martin, Berger, Klaus, Kuhlenbäumer, Gregor, Ringelstein, E Bernd, Stoll, Monika, Seedorf, Udo, Rothwell, Peter M, Powell, Janet T, Kuivaniemi, Helena, Onundarson, Pall T, Valdimarsson, Einar, Matthiasson, Stefan E, Gudbjartsson, Daniel F, Thorgeirsson, Guðmundur, Quyyumi, Arshed A, Watkins, Hugh, Farrall, Martin, Thorsteinsdottir, Unnur, Stefansson, Kari, Helgadottir, Anna, Gretarsdottir, Solveig, Thorleifsson, Gudmar, Holm, Hilma, Patel, Riyaz S, Gudnason, Thorarinn, Jones, Gregory T, van Rij, Andre M, Eapen, Danny J, Baas, Annette F, Tregouet, David-Alexandre, Morange, Pierre-Emmanuel, Emmerich, Joseph, Lindblad, Bengt, Gottsäter, Anders, Kiemeny, Lambertus A, Lindholt, Jes S., Sakalihasan, Natzi, Ferrell, Robert E, Carey, David J, Elmore, James R, Tsao, Philip S, Grarup, Niels, Jørgensen, Torben, Witte, Daniel R, Hansen, Torben, Pedersen, Oluf, Pola, Roberto, Gaetani, Eleonora, Magnadottir, Hulda B, Wijmenga, Cisca, Tromp, Gerard, Ronkainen, Antti, Ruigrok, Ynte M, Blankensteijn, Jan D, Mueller, Thomas, Wells, Philip S, Corral, Javier, Soria, Jose Manuel, Souto, Juan Carlos, Peden, John F, Jalilzadeh, Shapour, Mayosi, Bongani M, Keavney, Bernard, Strawbridge, Rona J, Sabater-Lleal, Maria, Gertow, Karl, Baldassarre, Damiano, Nyyssönen, Kristiina, Rauramaa, Rainer, Smit, Andries J, Mannarino, Elmo, Giral, Philippe, Tremoli, Elena, de Faire, Ulf, Humphries, Steve E, Hamsten, Anders, Haraldsdottir, Vilhelmina, Olafsson, Isleifur, Magnusson, Magnus K, Samani, Nilesh J, Levey, Allan I, Markus, Hugh S, Kostulas, Konstantinos, Dichgans, Martin, Berger, Klaus, Kuhlenbäumer, Gregor, Ringelstein, E Bernd, Stoll, Monika, Seedorf, Udo, Rothwell, Peter M, Powell, Janet T, Kuivaniemi, Helena, Onundarson, Pall T, Valdimarsson, Einar, Matthiasson, Stefan E, Gudbjartsson, Daniel F, Thorgeirsson, Guðmundur, Quyyumi, Arshed A, Watkins, Hugh, Farrall, Martin, Thorsteinsdottir, Unnur, and Stefansson, Kari

Abstract

The purpose of this study is investigate the effects of variants in the apolipoprotein(a) gene (LPA) on vascular diseases with different atherosclerotic and thrombotic components.

Published
2012

13. Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism

Author

Helgadottir, Anna, Gretarsdottir, Solveig, Thorleifsson, Gudmar, Holm, Hilma, Patel, Riyaz S, Gudnason, Thorarinn, Jones, Gregory T, van Rij, Andre M, Eapen, Danny J, Baas, Annette F, Tregouet, David-Alexandre, Morange, Pierre-Emmanuel, Emmerich, Joseph, Lindblad, Bengt, Gottsäter, Anders, Kiemeny, Lambertus A, Lindholt, Jes S., Sakalihasan, Natzi, Ferrell, Robert E, Carey, David J, Elmore, James R, Tsao, Philip S, Grarup, Niels, Jørgensen, Torben, Witte, Daniel R, Hansen, Torben, Pedersen, Oluf, Pola, Roberto, Gaetani, Eleonora, Magnadottir, Hulda B, Wijmenga, Cisca, Tromp, Gerard, Ronkainen, Antti, Ruigrok, Ynte M, Blankensteijn, Jan D, Mueller, Thomas, Wells, Philip S, Corral, Javier, Soria, Jose Manuel, Souto, Juan Carlos, Peden, John F, Jalilzadeh, Shapour, Mayosi, Bongani M, Keavney, Bernard, Strawbridge, Rona J, Sabater-Lleal, Maria, Gertow, Karl, Baldassarre, Damiano, Nyyssönen, Kristiina, Rauramaa, Rainer, Smit, Andries J, Mannarino, Elmo, Giral, Philippe, Tremoli, Elena, de Faire, Ulf, Humphries, Steve E, Hamsten, Anders, Haraldsdottir, Vilhelmina, Olafsson, Isleifur, Magnusson, Magnus K, Samani, Nilesh J, Levey, Allan I, Markus, Hugh S, Kostulas, Konstantinos, Dichgans, Martin, Berger, Klaus, Kuhlenbäumer, Gregor, Ringelstein, E Bernd, Stoll, Monika, Seedorf, Udo, Rothwell, Peter M, Powell, Janet T, Kuivaniemi, Helena, Onundarson, Pall T, Valdimarsson, Einar, Matthiasson, Stefan E, Gudbjartsson, Daniel F, Thorgeirsson, Guðmundur, Quyyumi, Arshed A, Watkins, Hugh, Farrall, Martin, Thorsteinsdottir, Unnur, Stefansson, Kari, Helgadottir, Anna, Gretarsdottir, Solveig, Thorleifsson, Gudmar, Holm, Hilma, Patel, Riyaz S, Gudnason, Thorarinn, Jones, Gregory T, van Rij, Andre M, Eapen, Danny J, Baas, Annette F, Tregouet, David-Alexandre, Morange, Pierre-Emmanuel, Emmerich, Joseph, Lindblad, Bengt, Gottsäter, Anders, Kiemeny, Lambertus A, Lindholt, Jes S., Sakalihasan, Natzi, Ferrell, Robert E, Carey, David J, Elmore, James R, Tsao, Philip S, Grarup, Niels, Jørgensen, Torben, Witte, Daniel R, Hansen, Torben, Pedersen, Oluf, Pola, Roberto, Gaetani, Eleonora, Magnadottir, Hulda B, Wijmenga, Cisca, Tromp, Gerard, Ronkainen, Antti, Ruigrok, Ynte M, Blankensteijn, Jan D, Mueller, Thomas, Wells, Philip S, Corral, Javier, Soria, Jose Manuel, Souto, Juan Carlos, Peden, John F, Jalilzadeh, Shapour, Mayosi, Bongani M, Keavney, Bernard, Strawbridge, Rona J, Sabater-Lleal, Maria, Gertow, Karl, Baldassarre, Damiano, Nyyssönen, Kristiina, Rauramaa, Rainer, Smit, Andries J, Mannarino, Elmo, Giral, Philippe, Tremoli, Elena, de Faire, Ulf, Humphries, Steve E, Hamsten, Anders, Haraldsdottir, Vilhelmina, Olafsson, Isleifur, Magnusson, Magnus K, Samani, Nilesh J, Levey, Allan I, Markus, Hugh S, Kostulas, Konstantinos, Dichgans, Martin, Berger, Klaus, Kuhlenbäumer, Gregor, Ringelstein, E Bernd, Stoll, Monika, Seedorf, Udo, Rothwell, Peter M, Powell, Janet T, Kuivaniemi, Helena, Onundarson, Pall T, Valdimarsson, Einar, Matthiasson, Stefan E, Gudbjartsson, Daniel F, Thorgeirsson, Guðmundur, Quyyumi, Arshed A, Watkins, Hugh, Farrall, Martin, Thorsteinsdottir, Unnur, and Stefansson, Kari

Abstract

The purpose of this study is investigate the effects of variants in the apolipoprotein(a) gene (LPA) on vascular diseases with different atherosclerotic and thrombotic components.

Published
2012

14. Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm

Author

Gretarsdottir, Solveig, Baas, Annette F, Thorleifsson, Gudmar, Holm, Hilma, den Heijer, Martin, de Vries, Jean-Paul P M, Kranendonk, Steef E, Zeebregts, Clark J A M, van Sterkenburg, Steven M, Geelkerken, Robert H, van Rij, Andre M, Williams, Michael J A, Boll, Albert P M, Kostic, Jelena P, Jonasdottir, Adalbjorg, Jonasdottir, Aslaug, Walters, G Bragi, Masson, Gisli, Sulem, Patrick, Saemundsdottir, Jona, Mouy, Magali, Magnusson, Kristinn P, Tromp, Gerard, Elmore, James R, Sakalihasan, Natzi, Limet, Raymond, Defraigne, Jean-Olivier, Ferrell, Robert E, Ronkainen, Antti, Ruigrok, Ynte M, Wijmenga, Cisca, Grobbee, Diederick E, Shah, Svati H, Granger, Christopher B, Quyyumi, Arshed A, Vaccarino, Viola, Patel, Riyaz S, Zafari, A Maziar, Levey, Allan I, Austin, Harland, Girelli, Domenico, Pignatti, Pier Franco, Olivieri, Oliviero, Martinelli, Nicola, Malerba, Giovanni, Trabetti, Elisabetta, Becker, Lewis C, Becker, Diane M, Reilly, Muredach P, Rader, Daniel J, Mueller, Thomas, Dieplinger, Benjamin, Haltmayer, Meinhard, Urbonavicius, Sigitas, Lindblad, Bengt, Gottsäter, Anders, Gaetani, Eleonora, Pola, Roberto, Wells, Philip, Rodger, Marc, Forgie, Melissa, Langlois, Nicole, Corral, Javier, Vasquez, Vicente, Fontcuberta, Jordi, España, Francisco, Grarup, Niels, Jørgensen, Torben, Witte, Daniel R, Hansen, Torben, Pedersen, Oluf, Aben, Katja K, de Graaf, Jacqueline, Holewijn, Suzanne, Folkersen, Lasse, Franco-Cereceda, Anders, Eriksson, Per, Collier, David A, Stefansson, Hreinn, Steinthorsdottir, Valgerdur, Rafnar, Thorunn, Valdimarsson, Einar M, Magnadottir, Hulda B, Sveinbjornsdottir, Sigurlaug, Olafsson, Isleifur, Magnusson, Magnus Karl, Palmason, Robert, Haraldsdottir, Vilhelmina, Andersen, Karl, Onundarson, Pall T, Thorgeirsson, Gudmundur, Kiemeney, Lambertus A, Powell, Janet T, Carey, David J, Kuivaniemi, Helena, Lindholt, Jes S., Jones, Gregory T, Kong, Augustine, Blankensteijn, Jan D, Matthiasson, Stefan E, Thorsteinsdottir, Unnur, Stefansson, Kari, Gretarsdottir, Solveig, Baas, Annette F, Thorleifsson, Gudmar, Holm, Hilma, den Heijer, Martin, de Vries, Jean-Paul P M, Kranendonk, Steef E, Zeebregts, Clark J A M, van Sterkenburg, Steven M, Geelkerken, Robert H, van Rij, Andre M, Williams, Michael J A, Boll, Albert P M, Kostic, Jelena P, Jonasdottir, Adalbjorg, Jonasdottir, Aslaug, Walters, G Bragi, Masson, Gisli, Sulem, Patrick, Saemundsdottir, Jona, Mouy, Magali, Magnusson, Kristinn P, Tromp, Gerard, Elmore, James R, Sakalihasan, Natzi, Limet, Raymond, Defraigne, Jean-Olivier, Ferrell, Robert E, Ronkainen, Antti, Ruigrok, Ynte M, Wijmenga, Cisca, Grobbee, Diederick E, Shah, Svati H, Granger, Christopher B, Quyyumi, Arshed A, Vaccarino, Viola, Patel, Riyaz S, Zafari, A Maziar, Levey, Allan I, Austin, Harland, Girelli, Domenico, Pignatti, Pier Franco, Olivieri, Oliviero, Martinelli, Nicola, Malerba, Giovanni, Trabetti, Elisabetta, Becker, Lewis C, Becker, Diane M, Reilly, Muredach P, Rader, Daniel J, Mueller, Thomas, Dieplinger, Benjamin, Haltmayer, Meinhard, Urbonavicius, Sigitas, Lindblad, Bengt, Gottsäter, Anders, Gaetani, Eleonora, Pola, Roberto, Wells, Philip, Rodger, Marc, Forgie, Melissa, Langlois, Nicole, Corral, Javier, Vasquez, Vicente, Fontcuberta, Jordi, España, Francisco, Grarup, Niels, Jørgensen, Torben, Witte, Daniel R, Hansen, Torben, Pedersen, Oluf, Aben, Katja K, de Graaf, Jacqueline, Holewijn, Suzanne, Folkersen, Lasse, Franco-Cereceda, Anders, Eriksson, Per, Collier, David A, Stefansson, Hreinn, Steinthorsdottir, Valgerdur, Rafnar, Thorunn, Valdimarsson, Einar M, Magnadottir, Hulda B, Sveinbjornsdottir, Sigurlaug, Olafsson, Isleifur, Magnusson, Magnus Karl, Palmason, Robert, Haraldsdottir, Vilhelmina, Andersen, Karl, Onundarson, Pall T, Thorgeirsson, Gudmundur, Kiemeney, Lambertus A, Powell, Janet T, Carey, David J, Kuivaniemi, Helena, Lindholt, Jes S., Jones, Gregory T, Kong, Augustine, Blankensteijn, Jan D, Matthiasson, Stefan E, Thorsteinsdottir, Unnur, and Stefansson, Kari

Abstract

We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseases-that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival.

Published
2010

15. Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm

Author

Gretarsdottir, Solveig, Baas, Annette F, Thorleifsson, Gudmar, Holm, Hilma, den Heijer, Martin, de Vries, Jean-Paul P M, Kranendonk, Steef E, Zeebregts, Clark J A M, van Sterkenburg, Steven M, Geelkerken, Robert H, van Rij, Andre M, Williams, Michael J A, Boll, Albert P M, Kostic, Jelena P, Jonasdottir, Adalbjorg, Jonasdottir, Aslaug, Walters, G Bragi, Masson, Gisli, Sulem, Patrick, Saemundsdottir, Jona, Mouy, Magali, Magnusson, Kristinn P, Tromp, Gerard, Elmore, James R, Sakalihasan, Natzi, Limet, Raymond, Defraigne, Jean-Olivier, Ferrell, Robert E, Ronkainen, Antti, Ruigrok, Ynte M, Wijmenga, Cisca, Grobbee, Diederick E, Shah, Svati H, Granger, Christopher B, Quyyumi, Arshed A, Vaccarino, Viola, Patel, Riyaz S, Zafari, A Maziar, Levey, Allan I, Austin, Harland, Girelli, Domenico, Pignatti, Pier Franco, Olivieri, Oliviero, Martinelli, Nicola, Malerba, Giovanni, Trabetti, Elisabetta, Becker, Lewis C, Becker, Diane M, Reilly, Muredach P, Rader, Daniel J, Mueller, Thomas, Dieplinger, Benjamin, Haltmayer, Meinhard, Urbonavicius, Sigitas, Lindblad, Bengt, Gottsäter, Anders, Gaetani, Eleonora, Pola, Roberto, Wells, Philip, Rodger, Marc, Forgie, Melissa, Langlois, Nicole, Corral, Javier, Vasquez, Vicente, Fontcuberta, Jordi, España, Francisco, Grarup, Niels, Jørgensen, Torben, Witte, Daniel R, Hansen, Torben, Pedersen, Oluf, Aben, Katja K, de Graaf, Jacqueline, Holewijn, Suzanne, Folkersen, Lasse, Franco-Cereceda, Anders, Eriksson, Per, Collier, David A, Stefansson, Hreinn, Steinthorsdottir, Valgerdur, Rafnar, Thorunn, Valdimarsson, Einar M, Magnadottir, Hulda B, Sveinbjornsdottir, Sigurlaug, Olafsson, Isleifur, Magnusson, Magnus Karl, Palmason, Robert, Haraldsdottir, Vilhelmina, Andersen, Karl, Onundarson, Pall T, Thorgeirsson, Gudmundur, Kiemeney, Lambertus A, Powell, Janet T, Carey, David J, Kuivaniemi, Helena, Lindholt, Jes S., Jones, Gregory T, Kong, Augustine, Blankensteijn, Jan D, Matthiasson, Stefan E, Thorsteinsdottir, Unnur, Stefansson, Kari, Gretarsdottir, Solveig, Baas, Annette F, Thorleifsson, Gudmar, Holm, Hilma, den Heijer, Martin, de Vries, Jean-Paul P M, Kranendonk, Steef E, Zeebregts, Clark J A M, van Sterkenburg, Steven M, Geelkerken, Robert H, van Rij, Andre M, Williams, Michael J A, Boll, Albert P M, Kostic, Jelena P, Jonasdottir, Adalbjorg, Jonasdottir, Aslaug, Walters, G Bragi, Masson, Gisli, Sulem, Patrick, Saemundsdottir, Jona, Mouy, Magali, Magnusson, Kristinn P, Tromp, Gerard, Elmore, James R, Sakalihasan, Natzi, Limet, Raymond, Defraigne, Jean-Olivier, Ferrell, Robert E, Ronkainen, Antti, Ruigrok, Ynte M, Wijmenga, Cisca, Grobbee, Diederick E, Shah, Svati H, Granger, Christopher B, Quyyumi, Arshed A, Vaccarino, Viola, Patel, Riyaz S, Zafari, A Maziar, Levey, Allan I, Austin, Harland, Girelli, Domenico, Pignatti, Pier Franco, Olivieri, Oliviero, Martinelli, Nicola, Malerba, Giovanni, Trabetti, Elisabetta, Becker, Lewis C, Becker, Diane M, Reilly, Muredach P, Rader, Daniel J, Mueller, Thomas, Dieplinger, Benjamin, Haltmayer, Meinhard, Urbonavicius, Sigitas, Lindblad, Bengt, Gottsäter, Anders, Gaetani, Eleonora, Pola, Roberto, Wells, Philip, Rodger, Marc, Forgie, Melissa, Langlois, Nicole, Corral, Javier, Vasquez, Vicente, Fontcuberta, Jordi, España, Francisco, Grarup, Niels, Jørgensen, Torben, Witte, Daniel R, Hansen, Torben, Pedersen, Oluf, Aben, Katja K, de Graaf, Jacqueline, Holewijn, Suzanne, Folkersen, Lasse, Franco-Cereceda, Anders, Eriksson, Per, Collier, David A, Stefansson, Hreinn, Steinthorsdottir, Valgerdur, Rafnar, Thorunn, Valdimarsson, Einar M, Magnadottir, Hulda B, Sveinbjornsdottir, Sigurlaug, Olafsson, Isleifur, Magnusson, Magnus Karl, Palmason, Robert, Haraldsdottir, Vilhelmina, Andersen, Karl, Onundarson, Pall T, Thorgeirsson, Gudmundur, Kiemeney, Lambertus A, Powell, Janet T, Carey, David J, Kuivaniemi, Helena, Lindholt, Jes S., Jones, Gregory T, Kong, Augustine, Blankensteijn, Jan D, Matthiasson, Stefan E, Thorsteinsdottir, Unnur, and Stefansson, Kari

Abstract

We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseases-that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival.

Published
2010

16. The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm

Author

Helgadottir, Anna, Thorleifsson, Gudmar, Magnusson, Kristinn P, Grétarsdottir, Solveig, Steinthorsdottir, Valgerdur, Manolescu, Andrei, Jones, Gregory T, Rinkel, Gabriel J E, Blankensteijn, Jan D, Ronkainen, Antti, Jääskeläinen, Juha E, Kyo, Yoshiki, Lenk, Guy M, Sakalihasan, Natzi, Kostulas, Konstantinos, Gottsäter, Anders, Flex, Andrea, Stefansson, Hreinn, Hansen, Torben, Andersen, Gitte, Weinsheimer, Shantel, Borch-Johnsen, Knut, Jørgensen, Torben, Shah, Svati H, Quyyumi, Arshed A, Granger, Christopher B, Reilly, Muredach P, Austin, Harland, Levey, Allan I, Vaccarino, Viola, Palsdottir, Ebba, Walters, G Bragi, Jonsdottir, Thorbjorg, Snorradottir, Steinunn, Magnusdottir, Dana, Gudmundsson, Gudmundur, Ferrell, Robert E, Sveinbjornsdottir, Sigurlaug, Hernesniemi, Juha, Niemelä, Mika, Limet, Raymond, Andersen, Karl, Sigurdsson, Gunnar, Benediktsson, Rafn, Verhoeven, Eric L G, Teijink, Joep A W, Grobbee, Diederick E, Rader, Daniel J, Collier, David A, Pedersen, Oluf, Pola, Roberto, Hillert, Jan, Lindblad, Bengt, Valdimarsson, Einar M, Magnadottir, Hulda B, Wijmenga, Cisca, Tromp, Gerard, Baas, Annette F, Ruigrok, Ynte M, van Rij, Andre M, Kuivaniemi, Helena, Powell, Janet T, Matthiasson, Stefan E, Gulcher, Jeffrey R, Thorgeirsson, Gudmundur, Kong, Augustine, Thorsteinsdottir, Unnur, Stefansson, Kari, Helgadottir, Anna, Thorleifsson, Gudmar, Magnusson, Kristinn P, Grétarsdottir, Solveig, Steinthorsdottir, Valgerdur, Manolescu, Andrei, Jones, Gregory T, Rinkel, Gabriel J E, Blankensteijn, Jan D, Ronkainen, Antti, Jääskeläinen, Juha E, Kyo, Yoshiki, Lenk, Guy M, Sakalihasan, Natzi, Kostulas, Konstantinos, Gottsäter, Anders, Flex, Andrea, Stefansson, Hreinn, Hansen, Torben, Andersen, Gitte, Weinsheimer, Shantel, Borch-Johnsen, Knut, Jørgensen, Torben, Shah, Svati H, Quyyumi, Arshed A, Granger, Christopher B, Reilly, Muredach P, Austin, Harland, Levey, Allan I, Vaccarino, Viola, Palsdottir, Ebba, Walters, G Bragi, Jonsdottir, Thorbjorg, Snorradottir, Steinunn, Magnusdottir, Dana, Gudmundsson, Gudmundur, Ferrell, Robert E, Sveinbjornsdottir, Sigurlaug, Hernesniemi, Juha, Niemelä, Mika, Limet, Raymond, Andersen, Karl, Sigurdsson, Gunnar, Benediktsson, Rafn, Verhoeven, Eric L G, Teijink, Joep A W, Grobbee, Diederick E, Rader, Daniel J, Collier, David A, Pedersen, Oluf, Pola, Roberto, Hillert, Jan, Lindblad, Bengt, Valdimarsson, Einar M, Magnadottir, Hulda B, Wijmenga, Cisca, Tromp, Gerard, Baas, Annette F, Ruigrok, Ynte M, van Rij, Andre M, Kuivaniemi, Helena, Powell, Janet T, Matthiasson, Stefan E, Gulcher, Jeffrey R, Thorgeirsson, Gudmundur, Kong, Augustine, Thorsteinsdottir, Unnur, and Stefansson, Kari

Abstract

Udgivelsesdato: 2008-Feb, Recently, two common sequence variants on 9p21, tagged by rs10757278-G and rs10811661-T, were reported to be associated with coronary artery disease (CAD) and type 2 diabetes (T2D), respectively. We proceeded to further investigate the contributions of these variants to arterial diseases and T2D. Here we report that rs10757278-G is associated with, in addition to CAD, abdominal aortic aneurysm (AAA; odds ratio (OR) = 1.31, P = 1.2 x 10(-12)) and intracranial aneurysm (OR = 1.29, P = 2.5 x 10(-6)), but not with T2D. This variant is the first to be described that affects the risk of AAA and intracranial aneurysm in many populations. The association of rs10811661-T to T2D replicates in our samples, but the variant does not associate with any of the five arterial diseases examined. These findings extend our insight into the role of the sequence variant tagged by rs10757278-G and show that it is not confined to atherosclerotic diseases.

Published
2008

17. The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm

Author

Helgadottir, Anna, Thorleifsson, Gudmar, Magnusson, Kristinn P, Grétarsdottir, Solveig, Steinthorsdottir, Valgerdur, Manolescu, Andrei, Jones, Gregory T, Rinkel, Gabriel J E, Blankensteijn, Jan D, Ronkainen, Antti, Jääskeläinen, Juha E, Kyo, Yoshiki, Lenk, Guy M, Sakalihasan, Natzi, Kostulas, Konstantinos, Gottsäter, Anders, Flex, Andrea, Stefansson, Hreinn, Hansen, Torben, Andersen, Gitte, Weinsheimer, Shantel, Borch-Johnsen, Knut, Jørgensen, Torben, Shah, Svati H, Quyyumi, Arshed A, Granger, Christopher B, Reilly, Muredach P, Austin, Harland, Levey, Allan I, Vaccarino, Viola, Palsdottir, Ebba, Walters, G Bragi, Jonsdottir, Thorbjorg, Snorradottir, Steinunn, Magnusdottir, Dana, Gudmundsson, Gudmundur, Ferrell, Robert E, Sveinbjornsdottir, Sigurlaug, Hernesniemi, Juha, Niemelä, Mika, Limet, Raymond, Andersen, Karl, Sigurdsson, Gunnar, Benediktsson, Rafn, Verhoeven, Eric L G, Teijink, Joep A W, Grobbee, Diederick E, Rader, Daniel J, Collier, David A, Pedersen, Oluf, Pola, Roberto, Hillert, Jan, Lindblad, Bengt, Valdimarsson, Einar M, Magnadottir, Hulda B, Wijmenga, Cisca, Tromp, Gerard, Baas, Annette F, Ruigrok, Ynte M, van Rij, Andre M, Kuivaniemi, Helena, Powell, Janet T, Matthiasson, Stefan E, Gulcher, Jeffrey R, Thorgeirsson, Gudmundur, Kong, Augustine, Thorsteinsdottir, Unnur, Stefansson, Kari, Helgadottir, Anna, Thorleifsson, Gudmar, Magnusson, Kristinn P, Grétarsdottir, Solveig, Steinthorsdottir, Valgerdur, Manolescu, Andrei, Jones, Gregory T, Rinkel, Gabriel J E, Blankensteijn, Jan D, Ronkainen, Antti, Jääskeläinen, Juha E, Kyo, Yoshiki, Lenk, Guy M, Sakalihasan, Natzi, Kostulas, Konstantinos, Gottsäter, Anders, Flex, Andrea, Stefansson, Hreinn, Hansen, Torben, Andersen, Gitte, Weinsheimer, Shantel, Borch-Johnsen, Knut, Jørgensen, Torben, Shah, Svati H, Quyyumi, Arshed A, Granger, Christopher B, Reilly, Muredach P, Austin, Harland, Levey, Allan I, Vaccarino, Viola, Palsdottir, Ebba, Walters, G Bragi, Jonsdottir, Thorbjorg, Snorradottir, Steinunn, Magnusdottir, Dana, Gudmundsson, Gudmundur, Ferrell, Robert E, Sveinbjornsdottir, Sigurlaug, Hernesniemi, Juha, Niemelä, Mika, Limet, Raymond, Andersen, Karl, Sigurdsson, Gunnar, Benediktsson, Rafn, Verhoeven, Eric L G, Teijink, Joep A W, Grobbee, Diederick E, Rader, Daniel J, Collier, David A, Pedersen, Oluf, Pola, Roberto, Hillert, Jan, Lindblad, Bengt, Valdimarsson, Einar M, Magnadottir, Hulda B, Wijmenga, Cisca, Tromp, Gerard, Baas, Annette F, Ruigrok, Ynte M, van Rij, Andre M, Kuivaniemi, Helena, Powell, Janet T, Matthiasson, Stefan E, Gulcher, Jeffrey R, Thorgeirsson, Gudmundur, Kong, Augustine, Thorsteinsdottir, Unnur, and Stefansson, Kari

Abstract

Udgivelsesdato: 2008-Feb, Recently, two common sequence variants on 9p21, tagged by rs10757278-G and rs10811661-T, were reported to be associated with coronary artery disease (CAD) and type 2 diabetes (T2D), respectively. We proceeded to further investigate the contributions of these variants to arterial diseases and T2D. Here we report that rs10757278-G is associated with, in addition to CAD, abdominal aortic aneurysm (AAA; odds ratio (OR) = 1.31, P = 1.2 x 10(-12)) and intracranial aneurysm (OR = 1.29, P = 2.5 x 10(-6)), but not with T2D. This variant is the first to be described that affects the risk of AAA and intracranial aneurysm in many populations. The association of rs10811661-T to T2D replicates in our samples, but the variant does not associate with any of the five arterial diseases examined. These findings extend our insight into the role of the sequence variant tagged by rs10757278-G and show that it is not confined to atherosclerotic diseases.

Published
2008

18. Integration of expression profiles and genetic mapping data to identify candidate genes in intracranial aneurysm.

Author

Weinsheimer, Shantel, Lenk, Guy M, van der Voet, Monique, Land, Susan, Ronkainen, Antti, Alafuzoff, Irina, Kuivaniemi, Helena, Tromp, Gerard, Weinsheimer, Shantel, Lenk, Guy M, van der Voet, Monique, Land, Susan, Ronkainen, Antti, Alafuzoff, Irina, Kuivaniemi, Helena, and Tromp, Gerard

Abstract

Intracranial aneurysm (IA) is a complex genetic disease for which, to date, 10 loci have been identified by linkage. Identification of the risk-conferring genes in the loci has proven difficult, since the regions often contain several hundreds of genes. An approach to prioritize positional candidate genes for further studies is to use gene expression data from diseased and nondiseased tissue. Genes that are not expressed, either in diseased or nondiseased tissue, are ranked as unlikely to contribute to the disease. We demonstrate an approach for integrating expression and genetic mapping data to identify likely pathways involved in the pathogenesis of a disease. We used expression profiles for IAs and nonaneurysmal intracranial arteries (IVs) together with the 10 reported linkage intervals for IA. Expressed genes were analyzed for membership in Kyoto Encyclopedia of Genes and Genomes (KEGG) biological pathways. The 10 IA loci harbor 1,858 candidate genes, of which 1,561 (84%) were represented on the microarrays. We identified 810 positional candidate genes for IA that were expressed in IVs or IAs. Pathway information was available for 294 of these genes and involved 32 KEGG biological function pathways represented on at least 2 loci. A likelihood-based score was calculated to rank pathways for involvement in the pathogenesis of IA. Adherens junction, MAPK, and Notch signaling pathways ranked high. Integration of gene expression profiles with genetic mapping data for IA provides an approach to identify candidate genes that are more likely to function in the pathology of IA.

Published
2007
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